metaM akg x
initial concentration: 1.0
is: SBO:0000247
constant: false
name: 2-oxoglutarate(2-)
boundary condition: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: CHEBI:16810
type: Species
initial amount: NaN
is: HMDB00208
has only substance units: false

metaR OCTAt
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110014#
is: SBO:0000185
reversible: true
reactant: MODEL1310110014#
name: Octanoate transport via diffusion

metaR SO4CLtex2
type: Reaction
product: MODEL1310110014#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
kinetic law: MODEL1310110014#
is described by: ECO:0000304
modifier: MODEL1310110014#
fast: false
name: sulfate transport via chloride countertransport (2:1)
reactant: MODEL1310110014#

metaR GLPASE2
product: MODEL1310110014#
name: glycogen phosphorylase (amyls -> glc-D)
reversible: false
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
type: Reaction
reactant: MODEL1310110014#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (5834.1) or (5836.1) or (5837.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 2.4.1.1 Confidence Level: 4 AUTHORS: PMID:3346228 NOTES:NCD

metaM retn e
has only substance units: false
is: HMDB01852
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: CHEBI:35291
name: all-trans-retinoate
boundary condition: false
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaR RE2987X
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:10970790,PMID:7775433 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
name: RE2987
is: SBO:0000176
reactant: MODEL1310110014#
modifier: MODEL1310110014#
fast: false
type: Reaction
kinetic law: MODEL1310110014#
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_6bef5f5c_1acc_474d_97ac_1a8016b7921b
boundary condition: true
is encoded by: hsa:51604
is encoded by: hsa:8733
constant: false
initial amount: NaN
has part: Q92643
is encoded by: hsa:94005
initial concentration: NaN
is encoded by: hsa:128869
name: PIGK:PIGU:PIGT:GPAA1:PIGS
has only substance units: false
has part: Q969N2
has part: Q8NBL9
has part: Q9H490
has part: O43292
is encoded by: hsa:10026
is: SBO:0000297
type: Species

metaM hxan e
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
constant: false
type: Species
name: hypoxanthine
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17368
is: HMDB00157
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR B3GNT310g
is described by: ECO:0000254
type: Reaction
product: MODEL1310110014#
reversible: false
reactant: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
is: SBO:0000176
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
modifier: MODEL1310110014#

metaR TSTSTERONEt
name: Testosterone transport
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110014#
product: MODEL1310110014#
fast: false
type: Reaction
reversible: true

metaM cdp e
type: Species
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: SBO:0000247
is: CHEBI:58069
boundary condition: false
constant: false
has only substance units: false
is: HMDB01546
name: CDP(3-)
initial amount: NaN
initial concentration: 1.0

metaM coa m
has only substance units: false
is: C00010
initial amount: NaN
is: CHEBI:57287
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: SBO:0000247
name: Coenzyme A
is: HMDB01423
boundary condition: false
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_b95bb227_5913_45e1_8cce_3177486fa047
has only substance units: false
initial concentration: NaN
boundary condition: true
name: SLC2A9
type: Species
constant: false
is encoded by: hsa:56606
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_4cf3cde3_3769_41cc_b616_9284988b7355
name: FOLR1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2348
boundary condition: true
has only substance units: false
constant: false
type: Species

metaM ile L c
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: HMDB00172
is: SBO:0000247
type: Species
name: L-isoleucine
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17191

metaR FAOXC14C14OHm
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C14OH)m
type: Reaction

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_8db506fb_d9c2_4cb9_9e88_a72ae6be7960
is: O95470
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:8879
is: SBO:0000252
constant: false
name: SGPL1
initial concentration: NaN

metaR HS1ly
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
fast: false
is described by: ECO:0000000
modifier: MODEL1310110014#
name: heparan-N-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.10.1.1
reversible: false
product: MODEL1310110014#

metaR TSTSTERONESte
product: MODEL1310110014#
reversible: true
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: sulfonated testosterone transport
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ

http://identifiers.org/biomodels.db/MODEL1310110014#_035fc2e9_48d5_414f_ac3f_d8e37410cb2f
is: P11712
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
name: CYP2C9
is encoded by: hsa:1559
is: SBO:0000252

metaR 3HBCOARc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (R)-3-hydroxybutanoyl-CoA into cytosol
type: Reaction

metaR r2202
fast: false
kinetic law: MODEL1310110014#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110014#

metaM estrones c
notes: FORMULA: C18H21O5S CHARGE: -1 INCHI: InChI=1S/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/p-1/t14-,15-,16+,18+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00961 EHMN_ABBREVIATION: C02538
is: HMDB01425
name: estrone 3-sulfate(1-)
has only substance units: false
is: CHEBI:60050
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
constant: false

metaR r0358
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110014#
reversible: false
reactant: MODEL1310110014#
fast: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.1
is described by: ECO:0000000
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_057fee4e_1f25_4e42_aa23_586f8dff7a01
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is: P31350
has only substance units: false
is encoded by: hsa:6241
initial amount: NaN
name: RRM2
initial concentration: NaN

metaR GLPASE1
reactant: MODEL1310110014#
product: MODEL1310110014#
modifier: MODEL1310110014#
name: glycogen phosphorylase (glygn2 -> dxtrn)
is version of: http://identifiers.org/ec-code/2.4.1.1
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (5834.1) or (5837.1) or (5836.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 2.4.1.1 Confidence Level: 4 AUTHORS: PMID:3346228 NOTES:NCD
kinetic law: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000176
fast: false

metaM 34dhoxpeg c
is: http://identifiers.org/pubchem.compound/7902
type: Species
is: SBO:0000247
is: HMDB00318
boundary condition: false
is: C05576
notes: FORMULA: C8H10O4 CHARGE: 0 INCHI: InChI=1/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2 EHMN_ABBREVIATION: C05576
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
name: 3,4-Dihydroxyphenylethyleneglycol

metaR RE3565C
type: Reaction
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
product: MODEL1310110014#
is described by: ECO:0000000
name: RE3565

metaR FAOXTC122m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization trans(C12:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_40cc62b2_8cfe_4b31_9a44_a0c9995be47f
has only substance units: false
is encoded by: hsa:4124
is: SBO:0000252
initial amount: NaN
is: Q16706
type: Species
name: MAN2A1
constant: false
boundary condition: true
initial concentration: NaN

metaM coa l
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: coenzyme A(4-)
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287
has only substance units: false
constant: false
is: HMDB01423
boundary condition: false
type: Species

metaM prostgf2 c
name: prostaglandin F2alpha(1-)
constant: false
is: SBO:0000247
is: HMDB01139
type: Species
boundary condition: false
is: CHEBI:57404
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639

metaR DOLPH Ler
kinetic law: MODEL1310110014#
fast: false
is described by: ECO:0000000
name: Dolichol-phosphate phosphohydrolase, human (liver)
product: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
is: SBO:0000176
type: Reaction
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_72143514_877d_40f8_b58f_63b4cccd9815
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:AV713053
constant: false
name: _AV713053_1_m
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_4f9b2ea0_9d70_4292_a090_22ed79d38c57
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4731
has only substance units: false
name: NDUFV3
type: Species
boundary condition: true

metaM hpdcacoa c
type: Species
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
name: heptadecanoyl coa
has only substance units: false
initial concentration: 1.0
is: HMDB06497
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false

metaM retinol e
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
initial amount: NaN
is: HMDB00305
is: CHEBI:50211
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: retinol
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_88a00fa4_1ce0_4afa_8820_f782aa68fe32
initial concentration: NaN
is: Q15181
boundary condition: true
has only substance units: false
initial amount: NaN
name: PPA1
type: Species
is encoded by: hsa:5464
constant: false
is: SBO:0000252

metaR FAOXC11C9m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C11-->C9)m
type: Reaction

metaM retn c
is: SBO:0000247
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
name: all-trans-retinoate
is: HMDB01852
is: CHEBI:35291
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
has only substance units: false

metaM fe2 c
name: Fe2+
constant: false
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: CHEBI:29033
initial amount: NaN
is: C00023
initial concentration: 1.0
is: HMDB00692

http://identifiers.org/biomodels.db/MODEL1310110014#_c984df35_f204_451b_849d_234f38b28010
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:10195
type: Species
has only substance units: false
constant: false
name: ALG3
is: SBO:0000252

metaM ppcoa x
has only substance units: false
is: SBO:0000247
is: HMDB01275
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
constant: false
is: CHEBI:57392
is: C00100
initial amount: NaN
boundary condition: false
name: Propanoyl-CoA
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_cb1ab1de_9da8_453a_87de_c0ba0770e01f
has only substance units: false
initial concentration: NaN
is: P42336
type: Species
constant: false
is encoded by: hsa:5290
name: PIK3CA
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR FAOXC226
modifier: MODEL1310110014#
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
name: Beta oxidation of long chain fatty acid
reversible: false
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
fast: false

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaR r0355
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110014#
fast: false
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/4.2.1.3
reactant: MODEL1310110014#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reversible: false
modifier: MODEL1310110014#
is described by: ECO:0000000

metaM ile L e
is: HMDB00172
is: CHEBI:17191
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
name: L-isoleucine
initial amount: NaN
constant: false
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0

metaM estrones e
notes: FORMULA: C18H21O5S CHARGE: -1 INCHI: InChI=1S/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/p-1/t14-,15-,16+,18+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00961 EHMN_ABBREVIATION: C02538
name: estrone 3-sulfate(1-)
is: CHEBI:60050
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: HMDB01425

metaR GHMT2rm
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
is: SBO:0000176
fast: false
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: true
product: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
name: glycine hydroxymethyltransferase, reversible, mitochondrial
is version of: http://identifiers.org/ec-code/2.1.2.1
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110014#_bcac7130_503b_4ea0_a9ef_a0fe8154df8d
has only substance units: false
is encoded by: hsa:39
initial concentration: NaN
boundary condition: true
type: Species
name: ACAT2
constant: false
is: SBO:0000252
is: Q9BWD1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_7de71ab9_ec14_492c_8284_fc2533762d27
is: O75521
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
name: ECI2
is: SBO:0000252
constant: false
is encoded by: hsa:10455
initial amount: NaN

metaM 34dhoxpeg e
is: C05576
constant: false
boundary condition: false
is: HMDB00318
is: http://identifiers.org/pubchem.compound/7902
is: SBO:0000247
type: Species
notes: FORMULA: C8H10O4 CHARGE: 0 INCHI: InChI=1/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2 EHMN_ABBREVIATION: C05576
has only substance units: false
name: 3,4-Dihydroxyphenylethyleneglycol
initial amount: NaN
initial concentration: 1.0

metaR ALDD21
reversible: false
notes: GENE_ASSOCIATION: (224.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:8528251 NOTES:NJ
modifier: MODEL1310110014#
is described by: ECO:0000304
reactant: MODEL1310110014#
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110014#
product: MODEL1310110014#
name: aldehyde dehydrogenase (pristanal, NAD)

metaM thmmp c
name: Thiamin monophosphate
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:37575
is: SBO:0000247
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
is: C01081
initial concentration: 1.0
is: HMDB02666
type: Species
has only substance units: false

metaM coa n
initial concentration: 1.0
is: SBO:0000247
name: coenzyme A(4-)
is: CHEBI:57287
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
constant: false
is: HMDB01423
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false

metaM 4hpro LT e
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00725
name: trans-4-hydroxy-L-proline
has only substance units: false
boundary condition: false

metaM ksi pre16 g
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:58053
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 16
has only substance units: false
type: Species
is: C00130
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
is: SBO:0000247

metaR C2tcx
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of acetylcarnitine from peroxisomes to cytosol
type: Reaction

metaR TMNDNCCPT2
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
reactant: MODEL1310110014#
is described by: ECO:0000000
kinetic law: MODEL1310110014#
is: SBO:0000176
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
reversible: false
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_fcb31df9_44c1_40e3_a2fd_229efeeed4eb
type: Species
is encoded by: hsa:51727
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: CMPK1
is: B2R6S5
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_0dbf67ce_a147_4c38_8c26_6fe0937d1459
name: CDS1
is encoded by: hsa:1040
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is: Q92903
initial concentration: NaN
type: Species
initial amount: NaN

metaM lnlccrn m
name: Linoleyl carnitine
is: HMDB06469
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
initial concentration: 1.0
type: Species
initial amount: NaN

metaR BILGLCURtr
kinetic law: MODEL1310110014#
fast: false
name: glucuronidated compound transport
is: SBO:0000185
reversible: true
product: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
type: Reaction
is described by: ECO:0000000

metaM HC01401 x
type: Species
has only substance units: false
name: (S)-3-Hydroxydodecanoyl-CoA
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
is: SBO:0000247
initial amount: NaN
is: CHEBI:27668
constant: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_a81063cc_27d2_4e87_99d1_003ea28747d5
initial amount: NaN
is: P00533
type: Species
boundary condition: true
name: EGFR
initial concentration: NaN
is encoded by: hsa:1956
is: SBO:0000252
has only substance units: false
constant: false

metaR r0571
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.17 Confidence Level: 0 AUTHORS: PMID:3071714,PMID:6885824 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.8
fast: false
product: MODEL1310110014#
name: (S)-Methylmalonyl-CoA hydrolase Propanoate metabolism EC:3.1.2.17
kinetic law: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
is: SBO:0000176
reversible: true

metaR EX urea LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urea exchange
type: Reaction

metaR FACOAL203
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
reversible: true
is: SBO:0000176
fast: false
is described by: ECO:0000000
modifier: MODEL1310110014#
product: MODEL1310110014#
type: Reaction

metaM amet m
name: S-Adenosyl-L-methionine
type: Species
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
initial amount: NaN
is: SBO:0000247
is: C00019
boundary condition: false
is: HMDB01185
initial concentration: 1.0
is: CHEBI:15414
has only substance units: false
constant: false

metaM 24nph c
initial concentration: 1.0
initial amount: NaN
name: 2-hydroxy-4-nitrophenolate
boundary condition: false
constant: false
is: HMDB02916
notes: FORMULA: C6H5NO4 CHARGE: 0 INCHI: InChI=1S/C6H5NO4/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,8-9H/p-1
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:57730

metaR FAOXC2452256x
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:5,n-6 -> c22:5, n-6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
product: MODEL1310110014#
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR r0047
type: Reaction
reactant: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#
is: SBO:0000176
product: MODEL1310110014#
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.16
is described by: ECO:0000000
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (1373.1) SUBSYSTEM: Purine catabolism EC Number: 3.1.3.5 Confidence Level: 0 AUTHORS: PMID:1550832 NOTES:
name: Adenosine 5-monophosphate phosphohydrolase Purine metabolism EC:3.1.3.5

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaR 3MOPte
name: Transport of 3-methyl-2-oxopentanoate
reactant: MODEL1310110014#
type: Reaction
is described by: ECO:0000134
reversible: true
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110014#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_5a3b4ad4_3c20_4b1b_9ab3_4b4331b5ac64
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
name: ATP2B2
is encoded by: hsa:491
is: Q4J699
is: SBO:0000252
constant: false
initial amount: NaN

metaM gdp n
constant: false
is: HMDB01201
has only substance units: false
is: CHEBI:58189
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial concentration: 1.0
name: GDP(3-)

metaM taur c
has only substance units: false
name: Taurine
notes: FORMULA: C2H7NO3S CHARGE: 0
is: CHEBI:3544
initial amount: NaN
is: SBO:0000247
is: HMDB00251
constant: false
is: C00245
initial concentration: 1.0
type: Species
boundary condition: false

metaM gm3 hs g
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
is: CHEBI:60065
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
initial concentration: 1.0

metaR FACOAL204
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110014#
is described by: ECO:0000269
product: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
modifier: MODEL1310110014#
is: SBO:0000176
fast: false
reactant: MODEL1310110014#
name: fatty-acid--CoA ligase

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaR ARACHCOAtx
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
name: fatty acid intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110014#

metaM ksii core2 deg9 l
is: SBO:0000247
constant: false
type: Species
boundary condition: false
is: CHEBI:12936
is: HMDB00143
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C30H50N3O20X CHARGE: 0
name: keratan sulfate II (core 2-linked), degradation product 9
initial amount: NaN

metaR EX tagat D LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Tagatose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_188e9043_5b5c_4eb1_b53b_6196d667e89c
constant: false
initial amount: NaN
type: Species
boundary condition: true
name: ABCB11
is: SBO:0000252
is: O95342
initial concentration: NaN
is encoded by: hsa:8647
has only substance units: false

metaM core2 g
is: CHEBI:15876
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
name: Core 2
notes: FORMULA: C22H37N2O15X CHARGE: 0

metaR DOCO13EFATP
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: absorption or uptake of 13-docosenoic acid into cells
type: Reaction

metaM hxan c
initial concentration: 1.0
is: C00262
constant: false
has only substance units: false
type: Species
is: HMDB00157
boundary condition: false
name: Hypoxanthine
initial amount: NaN
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: SBO:0000247
is: CHEBI:17368

metaR FAOXC5C5DCc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of glutaryl carnitine
type: Reaction

metaM cyst L c
is: HMDB00099
type: Species
is: SBO:0000247
name: L-cystathionine
is: CHEBI:17482
initial amount: NaN
boundary condition: false
notes: FORMULA: C7H14N2O4S CHARGE: 0 INCHI: InChI=1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00916
has only substance units: false
initial concentration: 1.0
constant: false

metaR CYTK3n
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
type: Reaction
modifier: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
name: cytidylate kinase (dCMP,CTP),nuclear
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM retinol 9 cis c
has only substance units: false
is: HMDB06217
constant: false
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
boundary condition: false
name: 9-cis-retinol
is: CHEBI:17336
initial amount: NaN
is: SBO:0000247
type: Species

metaR BACCL
is: SBO:0000176
product: MODEL1310110014#
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.10
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
reactant: MODEL1310110014#
name: biotin-[acetyl-CoA-carboxylase] ligase
is described by: ECO:0000269
reversible: false

metaM gdp m
is: CHEBI:58189
initial amount: NaN
is: C00035
constant: false
has only substance units: false
name: GDP
boundary condition: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial concentration: 1.0
is: SBO:0000247
is: HMDB01201
type: Species

metaR r2201
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110014#
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_a8ed1e19_e54d_4d8f_be2f_ad21e8488168
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
name: _H45672_1_m
is encoded by: hsa:H45672
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM cdp c
is: HMDB01546
initial amount: NaN
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP
boundary condition: false
is: CHEBI:58069
initial concentration: 1.0
is: C00112
is: SBO:0000247
type: Species
has only substance units: false
constant: false

metaR ATPtx
is: SBO:0000185
type: Reaction
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
reversible: true
name: ATP transporter, peroxisomal
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000000
fast: false

metaR FACOAL205
reversible: true
is: SBO:0000176
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
name: fatty-acid--CoA ligase

metaR S23T3g
is version of: http://identifiers.org/ec-code/2.4.99.6
product: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
is: SBO:0000176
reversible: false
type: Reaction
modifier: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD

metaM eitetcoa x
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
name: 5,8,11,14-eicosatetraenoylcoa
type: Species
has only substance units: false
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN

metaM 24nph e
name: 2-hydroxy-4-nitrophenolate
notes: FORMULA: C6H5NO4 CHARGE: 0 INCHI: InChI=1S/C6H5NO4/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,8-9H/p-1
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB02916
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:57730
boundary condition: false

metaM taur e
has only substance units: false
name: Taurine
initial amount: NaN
is: CHEBI:3544
is: SBO:0000247
notes: FORMULA: C2H7NO3S CHARGE: 0
constant: false
is: C00245
is: HMDB00251
type: Species
initial concentration: 1.0
boundary condition: false

metaR r2200
kinetic law: MODEL1310110014#
reversible: true
type: Reaction
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110014#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is: SBO:0000185
fast: false
product: MODEL1310110014#

metaR EX 24nph LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2,4 dihydroxy nitrophenol exchange
type: Reaction

metaR FUMSO4tm
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
name: Fumarate:sulfate antiport, mitochondrial
reactant: MODEL1310110014#
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110014#

metaM adrncoa x
constant: false
name: adrenyl coenzyme A
type: Species
initial concentration: 1.0
is: C16170
is: http://identifiers.org/pubchem.compound/47205480
is: SBO:0000247
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
boundary condition: false
initial amount: NaN
has only substance units: false

metaR r0908
type: Reaction
is: SBO:0000185
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
fast: false
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000000
reversible: true
name: Postulated transport reaction

metaR B3GALT3g
modifier: MODEL1310110014#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
reactant: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
name: Beta-1,3-galactosyltransferase 3
fast: false
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.79

metaM ksi pre20 g
initial concentration: 1.0
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
constant: false
name: keratan sulfate I biosynthesis, precursor 20
boundary condition: false
has only substance units: false
is: CHEBI:28067
type: Species
is: SBO:0000247
initial amount: NaN

metaM dmnoncoa x
boundary condition: false
is: HMDB11604
constant: false
type: Species
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
name: 4,8 dimethylnonanoyl-CoA
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaM retinol c
is: SBO:0000247
has only substance units: false
is: CHEBI:50211
initial amount: NaN
is: HMDB00305
initial concentration: 1.0
type: Species
constant: false
name: retinol
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3

metaR XYLtly
kinetic law: MODEL1310110014#
type: Reaction
is: SBO:0000185
reversible: false
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
name: Xylose efflux from lysosome

metaR FACOAL206
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: true
is: SBO:0000176
reactant: MODEL1310110014#
fast: false
modifier: MODEL1310110014#
type: Reaction
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110014#_74284246_269b_4dd9_8ddd_24e1e0266f59
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:7357
type: Species
is: SBO:0000252
name: UGCG
has only substance units: false
is: Q16739
initial amount: NaN

metaR r0570
product: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/6.3.3.2
is described by: ECO:0000000
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
fast: false

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_f3890982_a6f0_4807_bf48_edcf730137ce
type: Species
is: Q96C36
constant: false
name: PYCR2
is encoded by: hsa:29920
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_37418980_3cea_4deb_ae48_d3250225d2fa
name: PRDX3
constant: false
has only substance units: false
is: P30048
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10935
initial amount: NaN
is: SBO:0000252

metaR GUAPRT
is: SBO:0000176
reversible: false
type: Reaction
kinetic law: MODEL1310110014#
fast: false
reactant: MODEL1310110014#
name: guanine phosphoribosyltransferase
is version of: http://identifiers.org/ec-code/2.4.2.8
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
modifier: MODEL1310110014#
is described by: ECO:0000269

metaM cdp m
has only substance units: false
is: CHEBI:58069
boundary condition: false
is: SBO:0000247
name: CDP(3-)
type: Species
initial amount: NaN
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: HMDB01546
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_cabee8b9_000d_43c1_a46a_a46b127e7060
constant: false
type: Species
has part: P08559
has only substance units: false
is encoded by: hsa:5160
initial concentration: NaN
name: DLAT:DLD:PDHA1:PDHB:PDHX
boundary condition: true
initial amount: NaN
is: SBO:0000297

metaM 2dodtricoa x
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: 2,6,9-dodecatrienoylcoa
has only substance units: false
constant: false
is: HMDB11123
initial amount: NaN
is: C05279
notes: FORMULA: C33H48N7O17P3S CHARGE: -4

metaR S6T3g
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
modifier: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.17
product: MODEL1310110014#
is: SBO:0000176
reactant: MODEL1310110014#
reversible: false
kinetic law: MODEL1310110014#
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.21

metaR TETDEC2CRNe
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of tetradecadienoyl carnitine into extra cellular space
type: Reaction

metaR r1728
is described by: ECO:0000000
reversible: false
product: MODEL1310110014#
fast: false
reactant: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
modifier: MODEL1310110014#
is: SBO:0000185
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_ab5a2853_6e0c_4e07_b60f_6fa2236c7827
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is: P03897
name: ND3
is encoded by: hsa:4537

metaR EX 34dhphe LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxy-L-phenylalanine exchange
type: Reaction

metaM CE5118 m
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57923
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA

metaR P5CRxm
is: SBO:0000176
reversible: false
modifier: MODEL1310110014#
name: pyrroline-5-carboxylate reductase (m)
fast: false
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.5.1.2
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:PRO1x is irreversible in the other direction
is described by: ECO:0000304
kinetic law: MODEL1310110014#
product: MODEL1310110014#
type: Reaction

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaM retfa e
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
is: SBO:0000247
has only substance units: false
is: HMDB00508
boundary condition: false
constant: false
type: Species
is: CHEBI:15963
name: fatty acid retinol
initial concentration: 1.0
initial amount: NaN

metaR r1418
product: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000176
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
kinetic law: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reversible: true
reactant: MODEL1310110014#
fast: false

metaR LGNCCOAtx
kinetic law: MODEL1310110014#
reversible: true
reactant: MODEL1310110014#
name: fatty acid intracellular transport
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
product: MODEL1310110014#

metaM thmmp m
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:37575
initial concentration: 1.0
name: thiamine(1+) monophosphate(2-)
notes: FORMULA: C12H16N4O4PS CHARGE: -1 INCHI: InChI=1S/C12H17N4O4PS/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19)/p-1 EHMN_ABBREVIATION: C01081
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB02666

W3 CDTF: Thu Aug 30 17:05:21 BST 2012

metaM pro D e
boundary condition: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
type: Species
initial amount: NaN
initial concentration: 1.0
name: D-proline
has only substance units: false
is: CHEBI:16313
is: SBO:0000247
constant: false
is: HMDB03411

metaM gmp e
is: CHEBI:58115
initial concentration: 1.0
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
constant: false
is: SBO:0000247
type: Species
has only substance units: false
name: GMP(3-)
initial amount: NaN
is: HMDB01397
boundary condition: false

metaM estradiolglc r
initial concentration: 1.0
initial amount: NaN
is: CHEBI:36489
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C24H32O8 CHARGE: 0 INCHI: InChI=1S/C24H32O8/c1-24-9-8-14-13-5-3-12(10-11(13)2-4-15(14)16(24)6-7-17(24)25)31-23-20(28)18(26)19(27)21(32-23)22(29)30/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30)/t14-,15-,16+,17+,18+,19+,20-,21+,23-,24+/m1/s1
is: HMDB06224
name: 17beta-estradiol 3-glucosiduronic acid
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_392fd914_2a57_44fc_9841_a8f04ac323db
is encoded by: hsa:6513
is: SBO:0000252
boundary condition: true
name: SLC2A1
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: P11166

metaM 3ttetddcoa m
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB02014
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
initial amount: NaN
has only substance units: false
name: 3-hydroxy trans5,8tetradecadienoyl coa
initial concentration: 1.0
constant: false

metaR DMNONCRNCPT2
is: SBO:0000176
product: MODEL1310110014#
reversible: true
fast: false
kinetic law: MODEL1310110014#
name: DMNONCRNCPT2
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110014#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_43267254_2916_47e5_93e0_c5e6e576d1a6
boundary condition: true
initial amount: NaN
is encoded by: hsa:9197
is: SBO:0000252
constant: false
is: O00400
has only substance units: false
type: Species
initial concentration: NaN
name: SLC33A1

http://identifiers.org/biomodels.db/MODEL1310110014#_c1c90728_d809_4e4d_b9b7_ede1493f52ad
is encoded by: hsa:AI348006
initial amount: NaN
type: Species
name: _AI348006_1_c
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_c41a4528_5db8_4a2c_b70d_41964bb5aba6
boundary condition: true
is: O43280
is encoded by: hsa:11181
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: TREH

http://identifiers.org/biomodels.db/MODEL1310110014#_305eef97_3d76_4ad8_b6b8_fd91b8504216
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: HK1
is encoded by: hsa:3098
initial amount: NaN
has only substance units: false
type: Species
is: A8K7J7

W3 CDTF: Thu Aug 30 17:05:21 BST 2012

metaR r1952
modifier: MODEL1310110014#
reversible: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110014#
type: Reaction
name: Y+LAT2 Utilized transport
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#

metaR G14T9g
is described by: ECO:0000000
type: Reaction
reversible: false
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110014#
is: SBO:0000176

metaR PHYTt
reactant: MODEL1310110014#
type: Reaction
name: fatty acid transport via diffusion
reversible: true
kinetic law: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
fast: false

metaR SADT
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.1.25
type: Reaction
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000269
fast: false
name: sulfate adenylyltransferase
is: SBO:0000176
reversible: false

metaM coa x
constant: false
is: HMDB01423
is: SBO:0000247
is: CHEBI:57287
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: Coenzyme A
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: C00010

metaR RAI1
product: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
name: retinal isomerase (11-cis)
reversible: true
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110014#

metaR 5HOMEPRAZOLEte
kinetic law: MODEL1310110014#
is described by: ECO:0000000
fast: false
product: MODEL1310110014#
reactant: MODEL1310110014#
name: xenobiotic transport
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_310251fe_b3ba_4fd0_95cd_deab85458319
initial amount: NaN
name: PYCR1
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5831
is: A6NFM2
constant: false
has only substance units: false
boundary condition: true

metaR FAOXC141C121m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C12:1)m
type: Reaction

metaM ile L m
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
constant: false
is: HMDB00172
name: L-isoleucine
type: Species
is: CHEBI:17191
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR MAL Lte
type: Reaction
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110014#
fast: false
name: Transport of L-malate
product: MODEL1310110014#
reversible: true

metaM glcur l
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: CHEBI:15748
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: D-glucuronate
boundary condition: false
is: HMDB00127
initial concentration: 1.0

metaM tre e
has only substance units: false
type: Species
is: CHEBI:16551
is: C01083
is: HMDB00975
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
initial amount: NaN
name: Trehalose
initial concentration: 1.0

metaM cdp n
initial concentration: 1.0
is: HMDB01546
is: SBO:0000247
name: CDP(3-)
is: CHEBI:58069
boundary condition: false
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
has only substance units: false

metaM pro D c
boundary condition: false
is: HMDB03411
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
type: Species
initial concentration: 1.0
name: D-proline
has only substance units: false
initial amount: NaN
is: CHEBI:16313
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_18a430cb_1385_43e9_8705_62da74bea12f
type: Species
is encoded by: hsa:1103
is: SBO:0000252
initial amount: NaN
name: CHAT
has only substance units: false
initial concentration: NaN
constant: false
is: P28329
boundary condition: true

metaR C12OHc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdodecanoylcarnitinec
type: Reaction

metaR C3STDH1r
modifier: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
name: C-3 sterol dehydrogenase (4-methylzymosterol)
is: SBO:0000176
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.1.1.170
reversible: false
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ

metaM gmp g
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB01397
name: GMP(3-)
is: CHEBI:58115
type: Species

metaR FORtr
fast: false
is: SBO:0000185
kinetic law: MODEL1310110014#
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110014#
product: MODEL1310110014#
name: FOR transporter, endoplasmic reticulum

metaM ttdcrn c
name: tetradecanoyl carnitine
initial amount: NaN
constant: false
boundary condition: false
type: Species
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
is: http://identifiers.org/pubchem.compound/3413344
is: HMDB05066
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_a8639a76_a49a_419c_a175_1c5a2b2c1c1d
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q16134
name: ETFDH
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2110
constant: false

metaR FAOXC164C165x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)x
type: Reaction

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_fd46d696_32c5_42e2_98f9_78a2ff49d91c
constant: false
type: Species
initial amount: NaN
name: FOLR3
is: Q05C14
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2352
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_0954223b_3434_4d71_82bc_b145bb7a83c9
initial amount: NaN
type: Species
name: NDUFA3
constant: false
is: SBO:0000252
initial concentration: NaN
is: O95167
is encoded by: hsa:4696
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_eba5c02e_59b7_44e0_839e_5d45efed401c
name: PEMT
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:10400
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM fe2 e
initial amount: NaN
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: C00023
initial concentration: 1.0
name: Fe2+
is: HMDB00692
is: SBO:0000247
boundary condition: false
is: CHEBI:29033
constant: false
type: Species
has only substance units: false

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaM tettet6coa c
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205481
is: HMDB06516
constant: false
name: tetracosatetraenoyl coenzyme A
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
is: C16171
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR r1954
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction
reversible: false
reactant: MODEL1310110014#
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#

metaM hexde7coa x
name: 7-hexadecenoylcoa
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB02288
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0

metaR FATP2t
fast: false
name: fatty acid electroneutral transport
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
type: Reaction
reactant: MODEL1310110014#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110014#_3b7288e7_6fd5_40c3_b0e6_8d01b9bb6df4
is encoded by: hsa:53
name: ACP2
initial concentration: NaN
has only substance units: false
is: E9PCI1
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
boundary condition: true

metaR EX elaid LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: elaidic acid exchange
type: Reaction

metaM ksi deg22 l
is: CHEBI:16953
name: keratan sulfate I, degradation product 22
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00812
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C132H214N9O111S5 CHARGE: -5
has only substance units: false

metaR EX 3ddcrn
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_b5a515b9_ab68_4956_91bf_1e2578617947
is: O00754
initial amount: NaN
name: MAN2B1
has only substance units: false
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:4125
is: SBO:0000252

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_01c8fbf1_090e_4a22_a5d7_22627a5475ab
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
name: DPM3
has only substance units: false
is: SBO:0000252
is encoded by: hsa:54344
is: Q86TM7

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaM lnlccrn c
has only substance units: false
name: Linoleyl carnitine
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB06469
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
constant: false
type: Species
is: SBO:0000247

metaM c5dc e
initial amount: NaN
notes: FORMULA: C12H21NO6 CHARGE: 0
is: HMDB13130
is: SBO:0000247
has only substance units: false
name: glutaryl carnitine
boundary condition: false
constant: false
type: Species
initial concentration: 1.0

metaR SUBERICACT
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of suberic acid for formation of suberyl carnitine
type: Reaction

metaR HSD3B7P
product: MODEL1310110014#
name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
is described by: ECO:0000269
fast: false
reversible: false
kinetic law: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.181
modifier: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110014#_606b9beb_33e3_4d53_8916_2f5bf539e970
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
name: ELOVL5
type: Species
is encoded by: hsa:60481
is: F6SH78
boundary condition: true

metaM HC01401 m
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
initial concentration: 1.0
name: (S)-3-Hydroxydodecanoyl-CoA
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:27668
type: Species
boundary condition: false
initial amount: NaN

metaM 5hoxindact c
initial concentration: 1.0
is: CHEBI:50157
is: HMDB04073
constant: false
is: SBO:0000247
name: (5-hydroxyindol-3-yl)acetaldehyde
notes: FORMULA: C10H9NO2 CHARGE: 0 INCHI: InChI=1S/C10H9NO2/c12-4-3-7-6-11-10-2-1-8(13)5-9(7)10/h1-2,4-6,11,13H,3H2 HEPATONET_1.0_ABBREVIATION: HC01536 EHMN_ABBREVIATION: C05634
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species

metaR S6TASE3ly
reactant: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110014#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000

metaR M1316Mg
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
reactant: MODEL1310110014#
is: SBO:0000176
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
product: MODEL1310110014#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.114
is described by: ECO:0000000
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
reversible: false

metaM glcur r
is: CHEBI:15748
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: HMDB00127
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
name: D-glucuronate

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_d7983fc8_c2e7_42c1_b8e7_4cd29fce808b
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
name: _AI601100_1_m
is encoded by: hsa:AI601100
boundary condition: true
has only substance units: false

metaM 3snpyr m
is: HMDB02332
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
is: CHEBI:1665
boundary condition: false
type: Species
has only substance units: false
constant: false
is: SBO:0000247
name: 3-Sulfinopyruvate
initial amount: NaN
initial concentration: 1.0

metaR C121CPT1
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecenoylcarnitine
type: Reaction

metaM coa r
is: CHEBI:57287
is: C00010
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
has only substance units: false
name: Coenzyme A
is: HMDB01423
initial amount: NaN
is: SBO:0000247

metaM phe L c
constant: false
is: HMDB00159
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
type: Species
name: L-phenylalanine
is: CHEBI:17295

metaR 5MTHFt
kinetic law: MODEL1310110014#
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
modifier: MODEL1310110014#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
is described by: ECO:0000269
reactant: MODEL1310110014#
product: MODEL1310110014#
fast: false

metaM cs b l
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
is: HMDB02183
has only substance units: false
is: SBO:0000247
is: CHEBI:36005
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false

metaM retfa c
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:50211
name: fatty acid retinol
is: HMDB00305
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
constant: false

metaM prostgf2 e
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB01139
constant: false
is: CHEBI:57404
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
has only substance units: false
is: SBO:0000247
name: prostaglandin F2alpha(1-)

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR GLUt2m
reversible: true
name: L-glutamate reversible transport via proton symport, mitochondrial
is: SBO:0000185
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (83733.1) or (8604.1) or (79751.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reactant: MODEL1310110014#
fast: false
is described by: ECO:0000269
product: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#

metaM frdp c
is: C00448
name: Farnesyl diphosphate
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00961
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:175763
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448

metaR NACHEXA10ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
kinetic law: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
name: beta-N-acetylhexosaminidase A, lysosomal
reversible: false
modifier: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_535aa5f3_14b2_4357_94a0_6f26f3e24d70
name: UPP2
initial concentration: NaN
is: O95045
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:151531
type: Species
boundary condition: true
has only substance units: false

metaM gmp c
is: CHEBI:58115
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB01397
type: Species
name: GMP
is: C00144
initial amount: NaN

metaM hpdcacoa m
initial amount: NaN
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
is: SBO:0000247
name: heptadecanoyl coa
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: HMDB06497

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_4a6f6ee3_e07f_4810_b54f_c6d24445999f
is encoded by: hsa:51166
name: AADAT
is: SBO:0000252
is: Q8N5Z0
constant: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false

metaR r2082
type: Reaction
fast: false
reactant: MODEL1310110014#
is: SBO:0000185
product: MODEL1310110014#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
reversible: true
is described by: ECO:0000000

metaR r0156
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
reactant: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
type: Reaction
product: MODEL1310110014#
fast: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.1.40
kinetic law: MODEL1310110014#

metaR EX thf LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_405fc483_af2d_4079_a8dc_47e912574a66
is encoded by: hsa:5211
type: Species
initial concentration: NaN
constant: false
has part: Q7L2M7
has only substance units: false
is: SBO:0000297
name: PFKL:PFKP
initial amount: NaN
boundary condition: true

metaR GGLUCT
kinetic law: MODEL1310110014#
name: gamma-glutamylcyclotransferase
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
product: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.2.4
is described by: ECO:0000269
type: Reaction
fast: false

metaR DMNONCRNt
type: Reaction
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110014#
name: 4,8 dimethylnonanoyl carnitine transport (mitochondria)
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#

metaR r1636
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
modifier: MODEL1310110014#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_3e0df216_afbe_4e52_8d50_6b1fe7ada8e0
constant: false
is: SBO:0000252
name: NDUFA12
boundary condition: true
type: Species
is: F8VQS7
has only substance units: false
initial amount: NaN
is encoded by: hsa:55967
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_237b94ac_7e63_47b8_8508_b6c943ed01fb
is: SBO:0000252
name: SLC4A9
is encoded by: hsa:83697
initial amount: NaN
initial concentration: NaN
is: E9PDK1
boundary condition: true
type: Species
has only substance units: false
constant: false

metaR r0782
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: PMID:10410995,PMID:2428310,PMID:9603974 NOTES:
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110014#
name: GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) Fructose and mannose metabolism EC:1.1.1.271
is described by: ECO:0000000

metaR RE3006M
modifier: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE3006
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110014#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
type: Reaction

metaR r1884
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110014#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
product: MODEL1310110014#
is: SBO:0000185
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
fast: false

metaR r1946
name: Y+LAT2 Utilized transport
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: false
modifier: MODEL1310110014#

metaR r2083
kinetic law: MODEL1310110014#
fast: false
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000185
product: MODEL1310110014#
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110014#_14ecca53_aeb6_479b_b197_6d2bf7c8aec3
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI024818
type: Species
initial concentration: NaN
has only substance units: false
name: _AI024818_1_c
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_efff6079_4bc1_449b_ab2a_d225976a78ca
initial amount: NaN
is: Q6ZWT7
has only substance units: false
is: SBO:0000252
boundary condition: true
name: MBOAT2
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:129642

http://identifiers.org/biomodels.db/MODEL1310110014#_e5faf66d_3691_4b94_aa8e_9dd8a6e29312
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:126328
is: SBO:0000252
name: NDUFA11
is: C9JT23

http://identifiers.org/biomodels.db/MODEL1310110014#_87a50ca7_3ea9_4501_8c30_60377515da4f
constant: false
type: Species
boundary condition: true
name: _J03866_1_m
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:J03866

metaR r1637
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110014#
is: SBO:0000185
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#

metaM prostge1 e
is: HMDB01442
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:57397
type: Species
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: SBO:0000247
name: prostaglandin E1(1-)

http://identifiers.org/biomodels.db/MODEL1310110014#_9a0e36a1_29ff_46cb_8985_80b37c783e79
constant: false
is encoded by: hsa:18
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
name: ABAT
has only substance units: false

metaR r0781
fast: false
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110014#_5faed436_21b1_493b_9e1b_6da423e048b2
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:R06874
is: SBO:0000252
type: Species
name: _R06874_1_r
has only substance units: false

metaR GLYt7 311 r
modifier: MODEL1310110014#
name: glycine reversible transport via sodium and chloride symport (3:1:1)
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000006
is: SBO:0000185
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
product: MODEL1310110014#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_3f2ec5d6_594b_4e67_9c15_1e1c195cd462
is: SBO:0000252
is: Q96NT5
boundary condition: true
has only substance units: false
is encoded by: hsa:113235
name: SLC46A1
initial concentration: NaN
initial amount: NaN
constant: false
type: Species

metaM ocdececrn c
initial concentration: 1.0
notes: FORMULA: C25H47NO4 CHARGE: 0
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB06351
has only substance units: false
name: 11-octadecenoyl carnitine

metaR PRPPS
fast: false
product: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110014#
name: phosphoribosylpyrophosphate synthetase
is version of: http://identifiers.org/ec-code/2.7.6.1
is: SBO:0000176

metaR r1947
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
product: MODEL1310110014#
name: Y+LAT2 Utilized transport

metaR GALASE10ly
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
type: Reaction
is described by: ECO:0000000

metaR r2080
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110014#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110014#
is: SBO:0000185
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
reversible: true

metaR r0780
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
modifier: MODEL1310110014#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
fast: false
reversible: true
type: Reaction
is: SBO:0000176
reactant: MODEL1310110014#
is described by: ECO:0000000
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110014#

metaR FAOXC122C101m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

metaR r1634
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110014#
product: MODEL1310110014#
fast: false

metaM c5dc c
name: glutaryl carnitine
has only substance units: false
notes: FORMULA: C12H21NO6 CHARGE: 0
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB13130

http://identifiers.org/biomodels.db/MODEL1310110014#_d92c34bd_629e_4278_a729_84793475e507
is encoded by: hsa:55361
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is: Q9BTU6
name: PI4K2A
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_c30a9712_c791_4354_9792_8f70c1c5f107
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
is: P14324
initial amount: NaN
boundary condition: true
name: FDPS
is encoded by: hsa:2224

metaR EX 3deccrn
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydecanoyl carnitine
type: Reaction

metaM HC01412 m
name: trans-tetradec-2-enoyl-CoA(4-)
has only substance units: false
boundary condition: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
initial amount: NaN
is: SBO:0000247
is: CHEBI:61405
constant: false
type: Species
initial concentration: 1.0

metaM HC00591 m
constant: false
boundary condition: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
name: 2-oxoglutaramate
is: CHEBI:16769

http://identifiers.org/biomodels.db/MODEL1310110014#_f53fabfd_f2d0_4a63_9e02_9106b0b1000d
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
is: G0W2N5
is encoded by: hsa:6563
initial amount: NaN
constant: false
name: SLC14A1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_08de383e_d831_4e67_83ee_494ea0701f80
has only substance units: false
boundary condition: true
is: P48067
initial concentration: NaN
name: SLC6A9
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:6536

metaR FATP3t
kinetic law: MODEL1310110014#
reversible: true
modifier: MODEL1310110014#
name: fatty acid electroneutral transport
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reactant: MODEL1310110014#
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110014#

metaR FAOXC141C141OHm
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C14:1OH)m
type: Reaction

metaR RE1845C
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
product: MODEL1310110014#
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.65
name: RE1845
type: Reaction
reversible: true
fast: false

metaR r2081
modifier: MODEL1310110014#
fast: false
product: MODEL1310110014#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110014#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110014#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_e186bc32_e9b9_4080_80e2_7efae42939e9
has only substance units: false
is: SBO:0000252
boundary condition: true
is: P48751
initial amount: NaN
is encoded by: hsa:6508
constant: false
name: SLC4A3
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_c6b6118d_b7e2_4641_85bd_825d2b65bc78
has only substance units: false
name: ACAD11
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:84129
boundary condition: true
is: Q709F0
is: SBO:0000252
initial concentration: NaN

metaM prostge1 c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB01442
constant: false
is: CHEBI:57397
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
type: Species
boundary condition: false
name: prostaglandin E1(1-)

metaR r1635
reactant: MODEL1310110014#
product: MODEL1310110014#
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110014#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR H2Otg
product: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: H2O transport, Golgi apparatus
reversible: true
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_880fe4fc_3b47_46ab_b49c_c61c29f4e3c0
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:157570
is: Q56NI9
name: ESCO2
is: SBO:0000252
constant: false

metaM akg e
constant: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: SBO:0000247
name: 2-oxoglutarate(2-)
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00208
is: CHEBI:16810
boundary condition: false

metaR NACHEX19ly
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110014#
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
is: SBO:0000176
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000

metaR ARGN
notes: GENE_ASSOCIATION: (383.1) SUBSYSTEM: Urea cycle EC Number: 3.5.3.1 Confidence Level: 4 AUTHORS: PMID:1008818 NOTES:
name: arginase
is version of: http://identifiers.org/ec-code/3.5.3.1
is: SBO:0000176
type: Reaction
product: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#
is described by: ECO:0000134

metaM saccrp L m
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00279
type: Species
is: CHEBI:57951
notes: FORMULA: C11H19N2O6 CHARGE: -1 INCHI: InChI=1S/C11H20N2O6/c12-7(10(16)17)3-1-2-6-13-8(11(18)19)4-5-9(14)15/h7-8,13H,1-6,12H2,(H,14,15)(H,16,17)(H,18,19)/p-1/t7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00363
is: SBO:0000247
name: L-saccharopinate(1-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_9f1d7095_7258_4870_849c_01064a1cad61
name: PDE2A
initial concentration: NaN
type: Species
is: Q8IW54
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5138

metaR PFK26
is described by: ECO:0000000
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.1.105
name: 6-phosphofructo-2-kinase
reversible: false
is: SBO:0000176
type: Reaction
product: MODEL1310110014#
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (5210.1) or (5207.1) or (5209.1) or (5208.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.105 Confidence Level: 0 AUTHORS: NOTES:IF
fast: false

metaR CSPG Btly
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110014#
name: chondroitin sulfate B transport, extracellular to lysosome
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110014#_58d04542_b8c9_4f87_9e6a_5b576c10b00e
has only substance units: false
type: Species
name: NDUFA3
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:4696
is: O95167
initial concentration: NaN
is: SBO:0000252

metaR TETPENT3t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
kinetic law: MODEL1310110014#
name: fatty acid transport via diffusion
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110014#
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_876f036d_3414_44db_bb84_e68fde3605bc
is: P06737
name: PYGL
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:5836

http://identifiers.org/biomodels.db/MODEL1310110014#_metaM_galacglc13galacglcgal14acglcgalgluside_hs_g
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:26174
name: nLc8Cer
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaR INSTt4
name: inositol transport via sodium symport
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
reversible: true
product: MODEL1310110014#
fast: false
reactant: MODEL1310110014#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110014#

metaR 5HOXINDACTO2OX
modifier: MODEL1310110014#
product: MODEL1310110014#
reversible: false
is described by: ECO:0000304
fast: false
is: SBO:0000176
kinetic law: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.2.3.1
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.3.1 Confidence Level: 2 AUTHORS: PMID:11306106 NOTES:SAB questionable--balanced, but h2o2 production is based on an obscure comment in entrez
name: 5-Hydroxyindoleacetaldehyde:oxygen oxidoreductase

metaM retn r
name: all-trans-retinoate
is: SBO:0000247
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
constant: false
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB01852
is: CHEBI:35291

metaM akg c
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
name: 2-Oxoglutarate
is: HMDB00208
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:16810
is: C00026
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026

metaM L2aadp m
is: HMDB00510
constant: false
type: Species
name: L-2-aminoadipate(1-)
is: CHEBI:58672
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956

http://identifiers.org/biomodels.db/MODEL1310110014#_c65930c5_a9c9_41d7_bbdb_8257bd9072a0
initial amount: NaN
name: PGM2
is: SBO:0000252
is encoded by: hsa:55276
is: Q96G03
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_6f69aa7d_5721_473f_a976_98e50b15f0c3
initial amount: NaN
has only substance units: false
name: SLC23A2
type: Species
is encoded by: hsa:9962
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN

metaM 5forthf c
initial concentration: 1.0
constant: false
initial amount: NaN
name: 5-Formiminotetrahydrofolate
is: SBO:0000247
is: C00664
is: HMDB01534
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
is: CHEBI:57456
type: Species
has only substance units: false
boundary condition: false

metaM ei11ecoa x
constant: false
initial amount: NaN
name: 11-eicosenoylcoa
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM C05957 r
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: HMDB02710
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
initial amount: NaN
is: CHEBI:27485
name: Prostaglandin J2
boundary condition: false

metaM L2aadp6sa m
boundary condition: false
name: L-allysine
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
has only substance units: false
initial amount: NaN
is: CHEBI:17917
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB01263

http://identifiers.org/biomodels.db/MODEL1310110014#_e0181a4b_26cb_4ec6_b57d_07a9fa0c3178
is encoded by: hsa:83549
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species
name: UCK1
is: Q5JT09
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_91b4d14f_252d_4296_a4a3_299060a6077a
has part: C9JPQ8
is encoded by: hsa:5095
name: PCCA:PCCB
has only substance units: false
is encoded by: hsa:5096
initial concentration: NaN
type: Species
constant: false
has part: P05166
is: SBO:0000297
initial amount: NaN
boundary condition: true

metaR FAOXC164C143m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)m
type: Reaction

metaR IPDDIx
type: Reaction
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true
is: SBO:0000176
fast: false
is described by: ECO:0000134
name: isopentenyl-diphosphate D-isomerase
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
modifier: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/5.3.3.2

metaR HACD9m
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110014#
is described by: ECO:0000134
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
fast: false
is: SBO:0000176
type: Reaction
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110014#_090c5f45_aca7_4078_8d5a_9095b2e9e5d1
is: Q6I9V5
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
name: SLC25A6
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:293

metaR HEDCECRNe
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecenoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_5423454b_5bc8_441d_bfc2_395a764ac07e
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:284273
is: Q8N4Q0
name: ZADH2
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false

metaR r1638
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110014#
modifier: MODEL1310110014#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110014#

metaR r0784
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: true
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
reactant: MODEL1310110014#
type: Reaction
is: SBO:0000176
product: MODEL1310110014#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.38
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_8db5fbc7_778d_4d18_8eed_81fcdf46ad67
initial amount: NaN
name: RPE
constant: false
is: Q53TV9
boundary condition: true
is encoded by: hsa:6120
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_bed25a42_ac51_4f21_bebf_ddfa59f1e1de
has only substance units: false
boundary condition: true
name: NSDHL
initial amount: NaN
is: SBO:0000252
is: Q15738
constant: false
type: Species
is encoded by: hsa:50814
initial concentration: NaN

metaR r0157
kinetic law: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
type: Reaction
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/6.3.4.2
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
fast: false

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

metaR DOLGLCP Lter
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)
reversible: false

metaM lanost r
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
type: Species
is: CHEBI:16521
name: lanosterol
is: HMDB01251
boundary condition: false

metaR r1883
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110014#
product: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000185
fast: false
reactant: MODEL1310110014#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport

metaM vacccrn c
initial amount: NaN
boundary condition: false
type: Species
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
name: Vaccenyl carnitine
is: HMDB06351
initial concentration: 1.0

metaM HC01522 c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
is: SBO:0000247
is: CHEBI:28508
has only substance units: false
constant: false
name: Gentisate aldehyde
type: Species

metaM HC01459 x
is: SBO:0000247
is: CHEBI:27458
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
type: Species
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA

metaM tethex3coa c
initial concentration: 1.0
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
is: SBO:0000247
has only substance units: false
name: tetracosahexaenoyl coenzyme A
constant: false
is: C16168
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205478
is: HMDB06243
boundary condition: false
type: Species

metaM ppcoa c
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
has only substance units: false
initial amount: NaN
is: CHEBI:57392
is: HMDB01275
name: Propanoyl-CoA
is: C00100
constant: false

metaM ha pre1 l
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
initial concentration: 1.0
boundary condition: false
is: CHEBI:16126
name: hyaluronan biosynthesis, precursor 1
has only substance units: false
is: SBO:0000247

metaM 2mop m
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
name: 2-methyl-3-oxopropanoate
is: CHEBI:57700
is: HMDB01172
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: SBO:0000247

metaR r1639
kinetic law: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110014#
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110014#
product: MODEL1310110014#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR DASPO1p
notes: GENE_ASSOCIATION: (8528.2) or (8528.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 1.4.3.1 Confidence Level: 4 AUTHORS: PMID:12209855,PMID:9820813 NOTES:MM
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.4.3.1
type: Reaction
reversible: false
is: SBO:0000176
is described by: ECO:0000269
name: D-aspartate oxidase, peroxisomal
product: MODEL1310110014#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_095d15d7_f4af_4928_85f0_7340a4ec516b
is: SBO:0000252
constant: false
boundary condition: true
name: _AA629629_1_m
is encoded by: hsa:AA629629
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false

metaR r0783
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110014#
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
product: MODEL1310110014#
modifier: MODEL1310110014#
reversible: true
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM hdcoa c
is: SBO:0000247
constant: false
type: Species
name: Hexadecenoyl-CoA (n-C16:1CoA)
initial concentration: 1.0
is: HMDB06532
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
has only substance units: false
initial amount: NaN
boundary condition: false

metaM 2mcit c
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
is: CHEBI:15598
initial concentration: 1.0
name: 2-methylcitrate(3-)
is: HMDB00379
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
has only substance units: false
boundary condition: false

metaR CORE2GTg
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
fast: false
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110014#
type: Reaction
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.102
is: SBO:0000176
kinetic law: MODEL1310110014#
product: MODEL1310110014#

metaR ACCOAtn
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
name: acetyl-CoA transport, nuclear
product: MODEL1310110014#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_a2e0de38_9935_4eb7_b9be_a2e79915d94a
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: UROS
is: P10746
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:7390

metaM k e
is: SBO:0000247
is: C00238
has only substance units: false
is: HMDB00586
boundary condition: false
is: CHEBI:29103
initial concentration: 1.0
type: Species
name: potassium
constant: false
initial amount: NaN
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238

http://identifiers.org/biomodels.db/MODEL1310110014#_28e6607e_e026_4e2e_8a65_73bc49a365a0
is: P11586
type: Species
name: MTHFD1
is encoded by: hsa:4522
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_86139896_781f_4fd2_87f9_c4c88d91ce1d
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: CYP27A1
constant: false
initial amount: NaN
is encoded by: hsa:1593
has only substance units: false
type: Species
is: Q02318

metaM HC01412 x
initial amount: NaN
type: Species
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: trans-tetradec-2-enoyl-CoA(4-)
has only substance units: false
is: CHEBI:61405

http://identifiers.org/biomodels.db/MODEL1310110014#_3b19b69c_f153_468b_82ad_d3ea1d141f64
initial amount: NaN
name: PIGQ
initial concentration: NaN
has only substance units: false
is: Q9BRB3
constant: false
is encoded by: hsa:9091
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_d5f2eb1f_17c8_444f_bd29_5167e4687b13
initial concentration: NaN
initial amount: NaN
name: _AI990637_1_x
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:AI990637
has only substance units: false

metaM cys L e
has only substance units: false
name: L-cysteine
initial concentration: 1.0
constant: false
is: CHEBI:17561
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: HMDB00574

metaM tetde5coa x
type: Species
is: HMDB13109
is: SBO:0000247
name: 5-tetradecenoylcoa
constant: false
has only substance units: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR NRPPHRt4 2 r
is: SBO:0000185
type: Reaction
product: MODEL1310110014#
is described by: ECO:0000269
name: Norepinephrine reversible transport in via sodium symport (1:2)
reversible: true
modifier: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

metaM c226coa c
initial amount: NaN
type: Species
name: cervonyl coenzyme A
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205479
is: SBO:0000247
boundary condition: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: C16169
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_5b9b9841_f0b9_4df0_a719_d2ef43eb8bdf
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:23539
has only substance units: false
is: O95907
type: Species
name: SLC16A8
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_9a5012ec_a768_4f3e_9d6c_7cfcff83083f
is encoded by: hsa:27010
initial concentration: NaN
is: F5GZG6
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
constant: false
name: TPK1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_b39368f5_bfad_4571_ba7e_c3c44d088eca
name: LHPP
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q9H008
is encoded by: hsa:64077
type: Species
constant: false

metaM hdcoa m
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
name: Hexadecenoyl-CoA (n-C16:1CoA)
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB06532
has only substance units: false
type: Species
constant: false

metaR r0575
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.1.48
fast: false
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
reversible: true
kinetic law: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

metaM hpyr c
is: HMDB01352
initial concentration: 1.0
constant: false
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
name: 3-hydroxypyruvate
is: CHEBI:17180
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_a7f71503_b681_40a5_977a_d12dd5be1d4e
is encoded by: hsa:5298
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
name: PI4KB
initial concentration: NaN
is: Q9UBF8
is: SBO:0000252
type: Species

metaR r0909
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
reactant: MODEL1310110014#
type: Reaction
name: Transport reaction
kinetic law: MODEL1310110014#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_4ade0fa7_d299_412b_a025_0b534e61954d
initial concentration: NaN
is encoded by: hsa:5335
is: P19174
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
name: PLCG1
type: Species
has only substance units: false

metaR LINKDEG2ly
reversible: false
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110014#
name: degradation of proteoglycan linkage region, lysosomal
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110014#

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

http://identifiers.org/biomodels.db/MODEL1310110014#_3c0c121e_eec1_4b29_888a_894d3db93e70
name: NDUFS8
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:4728
is: O00217
constant: false
initial amount: NaN
has only substance units: false

metaM ppcoa m
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: C00100
is: SBO:0000247
type: Species
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: HMDB01275
boundary condition: false
name: Propanoyl-CoA
is: CHEBI:57392

metaR r0789
type: Reaction
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.14.13.15
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is: SBO:0000176
modifier: MODEL1310110014#
is described by: ECO:0000000
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reversible: true
product: MODEL1310110014#
fast: false

metaR r0268
type: Reaction
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.3.2
reversible: true
is described by: ECO:0000000
is: SBO:0000176
fast: false
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.3.1
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
modifier: MODEL1310110014#
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2

metaR S6TASE8ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: true
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
modifier: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000176
fast: false
name: N-acetylgalactosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110014#

metaM 2hexdtetcoa x
initial concentration: 1.0
constant: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB02288
name: 2,7,10,13-hexadecatetraenoylcoa
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_596058df_75ae_4a97_a6bc_6d70cd056b4a
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI971036
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
name: _AI971036_1_m

metaM 2mcit e
is: HMDB00379
is: CHEBI:15598
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
boundary condition: false
is: SBO:0000247
has only substance units: false
name: 2-methylcitrate(3-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_cec8ccc5_25b6_4250_9c95_230735fbcd61
name: ARSB
is encoded by: hsa:411
is: P15848
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaR G14T18g
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
product: MODEL1310110014#
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is: SBO:0000176
modifier: MODEL1310110014#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110014#

metaR RE3272N
reversible: true
kinetic law: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
product: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110014#
type: Reaction
name: RE3272

metaM k c
type: Species
initial concentration: 1.0
name: potassium
has only substance units: false
constant: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
boundary condition: false
is: SBO:0000247
is: C00238
initial amount: NaN
is: CHEBI:29103
is: HMDB00586

metaR RE1532M
kinetic law: MODEL1310110014#
reversible: true
is: SBO:0000176
name: RE1532
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

metaR PCHOLPm hs
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
modifier: MODEL1310110014#
is described by: ECO:0000269
kinetic law: MODEL1310110014#
name: choline phosphatase
type: Reaction
reactant: MODEL1310110014#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.4
fast: false
product: MODEL1310110014#

metaR SERGLYexR
fast: false
name: L-Serine/Glycine reversible exchange
modifier: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true

metaR r2088
type: Reaction
fast: false
reactant: MODEL1310110014#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000000

metaM ksii core4 pre5 g
is: CHEBI:58053
is: C00130
is: HMDB00175
type: Species
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 5
notes: FORMULA: C69H112N6O48X CHARGE: -1

metaR r0788
type: Reaction
modifier: MODEL1310110014#
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
product: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: true
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110014#

metaM hs deg12 l
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
boundary condition: false
type: Species
is: CHEBI:17180
has only substance units: false
is: HMDB01352
name: heparan sulfate, degradation product 12
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN

metaR r0267
type: Reaction
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.5.1.9
fast: false
product: MODEL1310110014#
reversible: true

metaM L2aadp c
boundary condition: false
is: CHEBI:58672
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: SBO:0000247
constant: false
initial amount: NaN
name: L-2-aminoadipate(1-)
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00510

metaM akg m
type: Species
initial amount: NaN
is: CHEBI:16810
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: C00026
is: HMDB00208
name: 2-Oxoglutarate
is: SBO:0000247
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
constant: false

metaR FAOXC164C143x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)x
type: Reaction

metaM coa g
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB01423
is: SBO:0000247
name: coenzyme A(4-)
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287
has only substance units: false

metaR r2089
fast: false
reactant: MODEL1310110014#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
reversible: true
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_e796d163_335b_4cfa_ae46_7cc7678b6144
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: B4DUG1
constant: false
boundary condition: true
is encoded by: hsa:9187
type: Species
initial amount: NaN
name: SLC24A1

metaM undcoa m
is: HMDB13114
boundary condition: false
name: undecanoylcoa
initial amount: NaN
has only substance units: false
notes: FORMULA: C32H52N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR r0787
fast: false
kinetic law: MODEL1310110014#
reversible: false
type: Reaction
reactant: MODEL1310110014#
modifier: MODEL1310110014#
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
is: SBO:0000176
product: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.1

http://identifiers.org/biomodels.db/MODEL1310110014#_b7a67145_129f_40f7_a8a4_613afd26d821
boundary condition: true
constant: false
is: P43251
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:686
name: BTD

metaM octe5coa x
type: Species
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: 5-octenoylcoa
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
constant: false

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaR r0354
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
reversible: false
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
modifier: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#

metaM L2aadp6sa c
name: L-allysine
is: CHEBI:17917
type: Species
constant: false
is: HMDB01263
has only substance units: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaM hista c
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: SBO:0000247
name: histamium
is: HMDB00870
is: CHEBI:58432
initial amount: NaN
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
has only substance units: false

metaR DTMPK
modifier: MODEL1310110014#
product: MODEL1310110014#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.9
is: SBO:0000176
name: dTMP kinase
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR r1527
is: SBO:0000185
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
fast: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.1
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#

metaM nicrnt c
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: C01185
initial concentration: 1.0
type: Species
constant: false
name: Nicotinate D-ribonucleotide
is: CHEBI:57502
has only substance units: false
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
is: HMDB01132

metaR r0265
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
reversible: false
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:8908517 NOTES:
name: ATP:D-galactose 1-phosphotransferase Galactose metabolism EC:2.7.1.6
type: Reaction

metaR r2086
product: MODEL1310110014#
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000185
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction

metaR r1632
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110014#
product: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
modifier: MODEL1310110014#

metaM mgacpail hs r
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
initial amount: NaN
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
is: C00249
is: HMDB00220
is: CHEBI:7896
is: SBO:0000247
boundary condition: false

metaM 3ddecdicoa m
is: HMDB03952
constant: false
type: Species
name: 3,6-dodecadienoylcoa
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: C05280

http://identifiers.org/biomodels.db/MODEL1310110014#_5d625ab1_22cc_4e21_a010_811e70d3a9b1
constant: false
name: PDHB
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5162
initial concentration: NaN
is: P11177

http://identifiers.org/biomodels.db/MODEL1310110014#_3293a16b_d0d7_4f95_954d_e879d63d4603
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:8170
is: SBO:0000252
name: SLC14A2
boundary condition: true
has only substance units: false
is: Q15849
type: Species

metaR TMDS
modifier: MODEL1310110014#
reversible: false
name: thymidylate synthase
is described by: ECO:0000269
reactant: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (7298.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.1.1.45 Confidence Level: 4 AUTHORS: PMID:14967037,PMID:2243092 NOTES:
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.1.1.45

metaM g1m8masn r
constant: false
has only substance units: false
boundary condition: false
type: Species
is: C05875
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C76H127N2O60X CHARGE: 0
is: SBO:0000247

metaR TMNDNCCPT1
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110014#
is: SBO:0000176
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_124b827c_ff6b_42c1_981d_a3af485b2c96
boundary condition: true
has only substance units: false
has part: O95498
is: SBO:0000297
type: Species
constant: false
is encoded by: hsa:8875
is encoded by: hsa:55350
initial amount: NaN
initial concentration: NaN
name: VNN3:VNN2:VNN1

metaR LDH D
kinetic law: MODEL1310110014#
fast: false
product: MODEL1310110014#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
type: Reaction
reversible: true
name: D-lactate dehydrogenase
reactant: MODEL1310110014#
is: SBO:0000176
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.1.2.4

metaM 2mop c
initial concentration: 1.0
is: HMDB01172
constant: false
is: CHEBI:57700
initial amount: NaN
type: Species
is: SBO:0000247
name: 2-methyl-3-oxopropanoate
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
has only substance units: false

metaR DM dttp m
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dTTP demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_3e67119f_743b_4ece_8188_3a2ccd56c833
boundary condition: true
name: ACADSB
is: P45954
constant: false
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:36
initial concentration: NaN
is: SBO:0000252

metaM zymst r
is: SBO:0000247
type: Species
is: HMDB06271
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:18252
name: zymosterol
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437

metaM ksi deg19 l
type: Species
notes: FORMULA: C146H236N10O124S6 CHARGE: -6
has only substance units: false
is: HMDB00812
name: keratan sulfate I, degradation product 19
constant: false
initial concentration: 1.0
is: CHEBI:16953
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR r1633
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110014#
product: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#

metaR r2087
product: MODEL1310110014#
reversible: true
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
type: Reaction
is: SBO:0000185
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110014#_f73724c4_ba8b_4c8a_b133_728afe8aeb77
is: Q8NFW8
has only substance units: false
name: CMAS
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:55907

http://identifiers.org/biomodels.db/MODEL1310110014#_51fb0891_acff_4fdf_bd29_8d50df5133c6
has only substance units: false
initial concentration: NaN
boundary condition: true
name: PIGL
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:9487
is: Q9Y2B2

metaR r0579
fast: false
reversible: true
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.13.11.19
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
type: Reaction
reactant: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110014#

metaR PI45P5P
kinetic law: MODEL1310110014#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
reactant: MODEL1310110014#
product: MODEL1310110014#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.36
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
is described by: ECO:0000000
fast: false
modifier: MODEL1310110014#

metaR UAG2EMAi
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.1.3.14
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110014#
fast: false
reversible: false
type: Reaction
name: UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
modifier: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#

metaM hista e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
has only substance units: false
initial amount: NaN
is: CHEBI:58432
name: histamium
is: SBO:0000247
constant: false
type: Species
is: HMDB00870

metaM Rtotal2 e
boundary condition: false
has only substance units: false
is: C00255
name: R total 2 position
type: Species
is: HMDB00244
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:3554
constant: false
notes: FORMULA: CO2FULLR2 CHARGE: -1

metaR C161CPT22
fast: false
modifier: MODEL1310110014#
is described by: ECO:0000269
type: Reaction
name: C161 transport into the mitochondria
is: SBO:0000176
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
product: MODEL1310110014#

metaR Q10H2e
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
kinetic law: MODEL1310110014#
is described by: ECO:0000134
name: transport of ubiquinol into lymph
type: Reaction
is: SBO:0000185
product: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true

metaR CDIPTr
is described by: ECO:0000000
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.8.11
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
name: phosphatidylinositol synthase (Homo sapiens)
fast: false
is: SBO:0000176
modifier: MODEL1310110014#
type: Reaction
reversible: true
reactant: MODEL1310110014#

metaR ACACT1r
fast: false
product: MODEL1310110014#
is described by: ECO:0000000
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
name: acetyl-CoA C-acetyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.9
reactant: MODEL1310110014#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110014#
reversible: true

metaM 2dodtricoa m
is: HMDB11123
type: Species
name: 2,6,9-dodecatrienoylcoa
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: C05279

metaR r2084
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110014#
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110014#
product: MODEL1310110014#

metaR r1630
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110014#
reversible: true
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_0ad024c9_f0be_4fc6_bd69_4ef66171d820
is: P05187
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:250
type: Species
name: ALPP
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_6a2bafa2_f277_49e8_9b57_364da04a515a
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
name: UROC1
constant: false
is: SBO:0000252
is encoded by: hsa:131669
initial amount: NaN
is: Q68CJ7

http://identifiers.org/biomodels.db/MODEL1310110014#_023d08e4_50f6_4781_acaa_bff2172ad59a
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3074
is: P07686
is: SBO:0000252
name: HEXB
initial amount: NaN
boundary condition: true

metaR r0578
is: SBO:0000176
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
product: MODEL1310110014#
modifier: MODEL1310110014#
reversible: true
is version of: http://identifiers.org/ec-code/4.1.2.27
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
type: Reaction

metaM 3hodcoa m
boundary condition: false
constant: false
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
name: (S)-3-Hydroxyoctadecanoyl-CoA
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5280355

http://identifiers.org/biomodels.db/MODEL1310110014#_84e48123_c024_4e63_90fa_79fda2163892
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:91373
is: Q3KQV9
is: SBO:0000252
type: Species
name: UAP1L1

metaM cys L c
name: L-cysteine
is: HMDB00574
type: Species
boundary condition: false
is: CHEBI:17561
constant: false
is: SBO:0000247
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR HMGCOASi
is described by: ECO:0000269
kinetic law: MODEL1310110014#
name: Hydroxymethylglutaryl CoA synthase (ir)
product: MODEL1310110014#
reversible: false
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (3157.1) or (3157.2) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:1358203 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission Made irreversible to match KEGG data for S. aureus
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.3.10
modifier: MODEL1310110014#
type: Reaction

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaR GAL3ST11
modifier: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.11
product: MODEL1310110014#
is described by: ECO:0000000
fast: false
name: Galactosylceramide sulfotransferase
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110014#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110014#_ae5141f6_8f45_43c9_9889_b04b418c8abf
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: E9PHN8
constant: false
name: HEPH
type: Species
has only substance units: false
is encoded by: hsa:9843
is: SBO:0000252

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_4427ef2d_ef70_4804_aa07_4ead26d91fa6
type: Species
boundary condition: true
name: DGAT1
initial amount: NaN
is: SBO:0000252
is: O75907
constant: false
has only substance units: false
is encoded by: hsa:8694
initial concentration: NaN

metaM ksi deg4 l
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
is: CHEBI:57737
type: Species
name: keratan sulfate I, degradation product 4
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00868
has only substance units: false

metaR r1631
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110014#

metaR DHCHOLESTANATEtm
kinetic law: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
is: SBO:0000185
reversible: true

metaR r2085
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
product: MODEL1310110014#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110014#
type: Reaction
fast: false
is: SBO:0000185

metaM coa c
is: HMDB01423
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: C00010
boundary condition: false
constant: false
is: CHEBI:3312
type: Species
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
name: Coenzyme A

metaM ksii core2 pre9 g
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
initial concentration: 1.0
is: CHEBI:28067
constant: false
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 9
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_13753409_15bf_4430_ae1d_0605e6d71acb
has only substance units: false
constant: false
is encoded by: hsa:54344
initial concentration: NaN
name: DPM3
type: Species
is: Q9P2X0
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR SACCD3m
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.8
fast: false
name: saccharopine dehydrogenase (NADP, L-lysine forming), mitochondrial
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.8 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
modifier: MODEL1310110014#

metaR r1421
reversible: true
name: Free diffusion
type: Reaction
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is described by: ECO:0000000
product: MODEL1310110014#
is: SBO:0000185
reactant: MODEL1310110014#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_d6a26fdb_49c0_4552_b34e_0d1306ad1fea
name: GDA
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q9Y2T3
has only substance units: false
type: Species
is encoded by: hsa:9615

metaM c6crn c
initial amount: NaN
is: HMDB00705
notes: FORMULA: C13H25NO4 CHARGE: 0
type: Species
initial concentration: 1.0
boundary condition: false
name: hexanoyl carnitine
has only substance units: false
constant: false
is: SBO:0000247

metaM HC02023 r
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:46898
initial concentration: 1.0
name: Cholesterol-ester-ol
constant: false
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
has only substance units: false
initial amount: NaN

metaR RE2986X
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:10970790,PMID:7775433 NOTES:
modifier: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE2986
reversible: true
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_c6ddae7c_2ecb_4d68_8c8b_eda279c5e5f5
initial amount: NaN
boundary condition: true
is: P20674
is encoded by: hsa:9377
constant: false
name: COX5A
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR GLYSNAT5tc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaM succoa c
has only substance units: false
boundary condition: false
is: HMDB01022
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
name: Succinyl-CoA
initial concentration: 1.0

metaR SUCCTD
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaM lnlncgcrn m
is: HMDB06318
name: gamma-linolenyl carnitine
has only substance units: false
type: Species
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1
initial amount: NaN

metaM for r
initial amount: NaN
type: Species
is: CHEBI:15740
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
constant: false
is: C00058
is: HMDB00142
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: Formate

metaR NDPK6m
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000176
product: MODEL1310110014#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reversible: true
is described by: ECO:0000254
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_8ad83aff_e278_4088_9605_ac67c4702f7f
initial concentration: NaN
has only substance units: false
is: Q96SL4
constant: false
is: SBO:0000252
name: GPX7
is encoded by: hsa:2882
initial amount: NaN
type: Species
boundary condition: true

metaM mi14p c
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
is: HMDB00968
is: CHEBI:58282
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM tdchola c
is: HMDB00951
name: taurochenodeoxycholate
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial concentration: 1.0
initial amount: NaN
is: CHEBI:9407
type: Species

metaM lald L c
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
type: Species
is: CHEBI:18041
name: (S)-lactaldehyde
boundary condition: false
is: HMDB03052

metaM ala L m
name: L-alanine
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:16977
type: Species
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
constant: false
is: HMDB00161
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_e9c400c8_8e0e_49b2_bbfe_a1f64f46f1f9
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
name: SCD
is: SBO:0000252
is: O00767
constant: false
is encoded by: hsa:6319
type: Species

metaM acgam c
initial amount: NaN
is: SBO:0000247
name: N-acetyl-D-glucosamine
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00215
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: CHEBI:17411

http://identifiers.org/biomodels.db/MODEL1310110014#_f6c985b2_6eee_4100_aabd_611a871a7403
constant: false
type: Species
is encoded by: hsa:7371
name: UCK2
is: Q9BZX2
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR EX tolbutamide LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tolbutamide exchange
type: Reaction

metaR P450SCC1m
reactant: MODEL1310110014#
reversible: true
name: cholesterol monooxygenase
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
type: Reaction
product: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false

metaM vacccrn m
has only substance units: false
initial concentration: 1.0
name: Vaccenyl carnitine
type: Species
initial amount: NaN
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
constant: false
boundary condition: false
is: HMDB06351
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_0cf3a00d_5360_42de_b61c_0802065da362
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:2581
is: P54803
type: Species
has only substance units: false
name: GALC
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_5b2c26a7_16e1_4e9d_9a09_8d23fe423fc9
type: Species
initial concentration: NaN
boundary condition: true
name: _AI818585_1_c
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:AI818585

http://identifiers.org/biomodels.db/MODEL1310110014#_1e8abd18_14e9_436e_9f14_30bfaf59ec5e
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:7296
boundary condition: true
has only substance units: false
constant: false
name: TXNRD1

metaM HC01414 x
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h10-11,18-20,24-26,30,41-42H,4-9,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b11-10+/t20-,24-,25-,26+,30-/m1/s1 EHMN_ABBREVIATION: C05275
boundary condition: false
is: CHEBI:61406
has only substance units: false
name: trans-dec-2-enoyl-CoA(4-)

metaR r0345
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
reversible: true
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
kinetic law: MODEL1310110014#
fast: false
reactant: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.3.99.13
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
is: SBO:0000176

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

metaR 3HCO3 NAt
is described by: ECO:0000134
name: 3HCO3_NAt
product: MODEL1310110014#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
reversible: true

metaM 4hexdtricoa m
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: 4,7,10-hexadecatrienoylcoa
is: HMDB02288
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
type: Species

metaR PSP L
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: phosphoserine phosphatase (L-serine)
is: SBO:0000176
reversible: false
product: MODEL1310110014#
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.3.3
type: Reaction
fast: false

metaM gthrd e
type: Species
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
name: glutathionate(1-)
constant: false
has only substance units: false
is: HMDB00125
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57925

http://identifiers.org/biomodels.db/MODEL1310110014#_ce348615_ab18_4b47_aec4_5cea57012e4f
boundary condition: true
is encoded by: hsa:55089
initial amount: NaN
is: Q969I6
type: Species
initial concentration: NaN
name: SLC38A4
has only substance units: false
is: SBO:0000252
constant: false

metaR GLCAASE9ly
kinetic law: MODEL1310110014#
is described by: ECO:0000269
fast: false
reversible: false
reactant: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
name: beta-glucuronidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.31
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
modifier: MODEL1310110014#
is: SBO:0000176

metaM subeac x
is: HMDB00893
type: Species
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
name: suberic acid
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C8H12O4 CHARGE: -2

metaM 20ahchsterol m
constant: false
is: HMDB06283
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
type: Species
is: CHEBI:1296
has only substance units: false
initial amount: NaN
boundary condition: false
name: 20-hydroxycholesterol

metaM mlthf c
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: C00143
boundary condition: false
initial amount: NaN
is: HMDB01533
type: Species
initial concentration: 1.0
has only substance units: false
name: 5,10-Methylenetetrahydrofolate
is: CHEBI:15636
is: SBO:0000247
constant: false

metaR RE0577C
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.2
reactant: MODEL1310110014#
reversible: true
name: RE0577
is: SBO:0000176
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
product: MODEL1310110014#

metaM acrn x
is: CHEBI:57589
type: Species
initial concentration: 1.0
name: O-acetylcarnitine
boundary condition: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00201
constant: false

metaR P4502C19
product: MODEL1310110014#
is described by: ECO:0000000
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.48
name: cytochrome P450 2C19
notes: GENE_ASSOCIATION: (1557.1) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15579107,PMID:3442670 NOTES:omeprazole 5 methyl hydroxylation assumed to take place on outer membrane - since a xenobiotic NJ
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
reactant: MODEL1310110014#

metaM c8dc c
is: SBO:0000247
initial amount: NaN
is: HMDB00791
initial concentration: 1.0
name: suberyl carnitine
has only substance units: false
is: C02838
constant: false
boundary condition: false
type: Species
notes: FORMULA: C15H26NO6 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110014#_3f78e35e_5713_409a_b377_a1790d82a442
constant: false
initial amount: NaN
name: _83530_1_c
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:83530
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_0a9433e4_6170_4bbe_9515_c482e9183651
is: Q53XN1
initial concentration: NaN
name: COX8A
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:1351
is: SBO:0000252

metaR GPIMTer L
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
fast: false
is described by: ECO:0000000
reactant: MODEL1310110014#
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
reversible: false
kinetic law: MODEL1310110014#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110014#
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_1be94a19_b952_425b_be2a_fea3f90f7a8d
boundary condition: true
is encoded by: hsa:28231
type: Species
constant: false
has only substance units: false
name: SLCO4A1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q96BD0

http://identifiers.org/biomodels.db/MODEL1310110014#_a64a0e36_bba3_403e_9625_9b6ff8895d15
is: P54802
name: NAGLU
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:4669

http://identifiers.org/biomodels.db/MODEL1310110014#_478d9664_0f9d_4849_94b3_93a0700756aa
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is: Q6LEN5
name: CHAT
boundary condition: true
is encoded by: hsa:1103

metaM h2o2 m
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: CHEBI:16240
is: C00027
has only substance units: false
is: HMDB03125
name: Hydrogen peroxide

metaR DM atp c
reactant: MODEL1310110014#
is described by: ECO:0000134
name: DM_atp(c)
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
kinetic law: MODEL1310110014#
fast: false
reversible: false
type: Reaction
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_455a00fc_c1df_4181_a7c9_35059c0e9fbc
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6817
initial concentration: NaN
type: Species
name: SULT1A1

http://identifiers.org/biomodels.db/MODEL1310110014#_d34a9866_50b0_440b_9489_24cf611fc0a9
initial amount: NaN
is encoded by: hsa:4598
initial concentration: NaN
name: MVK
has only substance units: false
is: SBO:0000252
constant: false
is: B2RDU6
boundary condition: true
type: Species

metaR EX hpdca LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptadecanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_f45df109_5527_49c9_bbe0_d102b7a6d10b
type: Species
is: SBO:0000252
constant: false
is: P56181
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4731
name: NDUFV3
boundary condition: true
initial amount: NaN

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaR RDH1
modifier: MODEL1310110014#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.315
name: retinol dehydrogenase (all-trans)
product: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110014#
type: Reaction

metaR MTHFR3
name: 5,10-methylenetetrahydrofolatereductase (NADPH)
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (4524.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 2 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 350. NOTES:absorbed folate undergoes conversion to 5-methyl-THF within the enterocytes.
modifier: MODEL1310110014#
reversible: false
is described by: ECO:0000134
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.20
type: Reaction

metaM gthrd c
initial amount: NaN
has only substance units: false
is: C00051
name: Reduced glutathione
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: HMDB00125
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:57925

http://identifiers.org/biomodels.db/MODEL1310110014#_d4f4e387_a7f3_492e_80aa_34f077084731
is encoded by: hsa:4597
name: MVD
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is: P53602
initial amount: NaN
has only substance units: false
constant: false

metaR UDPG4E
fast: false
name: UDPglucose 4-epimerase
is version of: http://identifiers.org/ec-code/5.1.3.2
product: MODEL1310110014#
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
is: SBO:0000176
reversible: true
reactant: MODEL1310110014#

metaM cs a l
is: SBO:0000247
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
type: Species
constant: false
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
is: CHEBI:36005
is: HMDB02183
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR ABO9g
type: Reaction
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
product: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
reactant: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.37
modifier: MODEL1310110014#

metaM h2o2 n
is: HMDB03125
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:16240
has only substance units: false
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial concentration: 1.0
name: hydrogen peroxide
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_a82fcfc8_1948_42c3_a34e_84433d5a8aa6
has only substance units: false
is: P05166
name: PCCB
is encoded by: hsa:5096
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM strdnccoa x
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: SBO:0000247
has only substance units: false
name: stearidonyl coenzyme A
initial amount: NaN
is: HMDB06519
is: http://identifiers.org/pubchem.compound/47205473
initial concentration: 1.0
type: Species
is: C16163
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_52a8fca6_8a7a_4599_98ef_d2efa608ae92
boundary condition: true
name: HSD3B1
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3283
initial amount: NaN
type: Species
is: P14060

http://identifiers.org/biomodels.db/MODEL1310110014#_cc9c81d3_875d_4e52_bfe5_b5688670c8f2
is: Q9H903
is encoded by: hsa:441024
initial concentration: NaN
type: Species
constant: false
name: MTHFD2L
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR r0033
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
is described by: ECO:0000000
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176
reactant: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_7b59b246_50e7_4063_aa1f_cdb21a8dcfd8
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: O95954
constant: false
is encoded by: hsa:10841
name: FTCD

metaR FOLTle
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: folate uptake into the enterocytes
type: Reaction

metaR RDH2
reversible: true
type: Reaction
is: SBO:0000176
product: MODEL1310110014#
fast: false
modifier: MODEL1310110014#
is described by: ECO:0000269
name: retinol dehydrogenase (9-cis,NADH)
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.315

metaR DURItn
product: MODEL1310110014#
fast: false
is described by: ECO:0000000
name: deoxyuridine transport in nucleus
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110014#
reversible: true
reactant: MODEL1310110014#

metaM hedepecoa m
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
name: 2,4,7,10,13-hexadecapentenoylcoa
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: HMDB02288
boundary condition: false
is: SBO:0000247

metaM m5mpdol L r
is: SBO:0000247
constant: false
boundary condition: false
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
notes: FORMULA: C1600H2628N20O470P20 CHARGE: -20
type: Species
is: CHEBI:37634
initial concentration: 1.0
initial amount: NaN

metaM 3hdcoa c
name: (S)-3-Hydroxydecanoyl-CoA
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00651
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_3e7e98b2_9aa6_4e5b_9e64_ed12034e340c
has part: E9PB82
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:3295
initial amount: NaN
boundary condition: true
name: ACAA1:HSD17B4:ACOX1
has only substance units: false
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110014#_49326a6a_25ee_4c24_9049_17f9104c00ac
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
name: NDUFA11
constant: false
is encoded by: hsa:126328
initial amount: NaN
initial concentration: NaN
is: C9JT23

metaR CYTK4n
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110014#
name: cytidylate kinase (dCMP,GTP),nuclear
kinetic law: MODEL1310110014#
fast: false
type: Reaction
product: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true

metaR PTE3x
product: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
name: peroxisomal acyl-CoA thioesterase
reversible: false
is: SBO:0000176
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000000

metaM nh4 x
initial concentration: 1.0
constant: false
type: Species
is: C01342
name: Ammonium
has only substance units: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: HMDB00051
boundary condition: false
is: CHEBI:28938
initial amount: NaN
is: SBO:0000247

metaR GCHOLAt3
notes: GENE_ASSOCIATION: (8714.3) or (8647.1) or (8714.2) or (8714.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9738950,PMID:9806540,PMID:9813153 NOTES:for bile acid secretion into bile NJ
name: ABC bile acid transporter
reactant: MODEL1310110014#
is described by: ECO:0000269
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000185
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_e75e4a18_cbb2_48f4_865a_19f7a0bbc730
initial amount: NaN
is encoded by: hsa:AA081045
boundary condition: true
name: _AA081045_1_m
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN

metaR BAAT2x
is: SBO:0000176
kinetic law: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
modifier: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: false
product: MODEL1310110014#
is described by: ECO:0000269
name: bile acid Coenzyme A: amino acid N-acyltransferase

metaR S23T2g
type: Reaction
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
modifier: MODEL1310110014#
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.99.4
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110014#_551555e1_daa5_4714_8c83_72180eb0062b
is encoded by: hsa:10786
is: O00476
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: SLC17A3
type: Species
boundary condition: true
is: SBO:0000252

metaM cysam e
name: cysteaminium
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:58029
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1
is: HMDB02991
type: Species

metaR RDH3
is: SBO:0000176
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.1.1.315
name: retinol dehydrogenase (11-cis,NADH)
product: MODEL1310110014#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
type: Reaction

metaR HEXCt
type: Reaction
is: SBO:0000185
reactant: MODEL1310110014#
name: fatty acid transport via diffusion
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaR GCALDD
product: MODEL1310110014#
reversible: false
name: Glycolaldehyde dehydrogenase
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
kinetic law: MODEL1310110014#
type: Reaction
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.1.36

metaM maltpt e
is: HMDB01296
constant: false
has only substance units: false
type: Species
name: maltopentaose
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
is: http://identifiers.org/pubchem.compound/5141
is: C02052

metaM sarcs m
is: C00213
is: CHEBI:15611
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
name: Sarcosine
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00271
is: SBO:0000247
constant: false
type: Species

metaR EX pectindchac LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectin-deoxycholic acid complex
type: Reaction

metaM HC00591 c
constant: false
boundary condition: false
type: Species
is: CHEBI:16769
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: 2-oxoglutaramate
initial amount: NaN

metaM HC01434 x
name: oxalatosuccinate(3-)
has only substance units: false
constant: false
is: CHEBI:58931
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
boundary condition: false
is: SBO:0000247

metaR IDOAASE2ly
name: alpha-L-iduronidase, lysosomal
modifier: MODEL1310110014#
reactant: MODEL1310110014#
reversible: false
type: Reaction
kinetic law: MODEL1310110014#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is: SBO:0000176
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.76

http://identifiers.org/biomodels.db/MODEL1310110014#_24c4a1c8_f09b_42d5_8896_f5a19d4794b6
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:5143
name: PDE4C
initial concentration: NaN
is: Q7KYS4
is: SBO:0000252
initial amount: NaN

metaR CLPNDCOAtx
is: SBO:0000185
reactant: MODEL1310110014#
reversible: true
is described by: ECO:0000000
name: fatty acid intracellular transport
kinetic law: MODEL1310110014#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_5c369c94_2ccb_4701_8b8e_e6d505fc7d32
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P24298
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:2875
name: GPT

metaR GRTTx
reactant: MODEL1310110014#
name: geranyltranstransferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.5.1.1
fast: false
is: SBO:0000176
is described by: ECO:0000134
modifier: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
reversible: false
kinetic law: MODEL1310110014#

metaM tdchola e
boundary condition: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial amount: NaN
name: taurochenodeoxycholate
is: HMDB00951
constant: false
is: CHEBI:9407
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR C160CRNt
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
reactant: MODEL1310110014#
is described by: ECO:0000269
reversible: false
fast: false
type: Reaction
is: SBO:0000185
name: C160 transport into the mitochondria
product: MODEL1310110014#
kinetic law: MODEL1310110014#

metaR PPPGOm
fast: false
notes: GENE_ASSOCIATION: (5498.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.4 Confidence Level: 2 AUTHORS: PMID:8771201 NOTES:NCD
reactant: MODEL1310110014#
is described by: ECO:0000304
product: MODEL1310110014#
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.3.3.4
type: Reaction
kinetic law: MODEL1310110014#
is: SBO:0000176
name: protoporphyrinogen oxidase, mitochondrial
reversible: false

metaR RDH4
modifier: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.315
name: retinol dehydrogenase (13-cis,NADH)
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:9115228 NOTES:IT
fast: false
product: MODEL1310110014#
type: Reaction

metaR r0560
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
reactant: MODEL1310110014#
fast: false
type: Reaction
product: MODEL1310110014#
is: SBO:0000176
kinetic law: MODEL1310110014#
reversible: false
is described by: ECO:0000000
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2

http://identifiers.org/biomodels.db/MODEL1310110014#_fbc564fe_24b1_4808_a813_7158da86d6af
is: SBO:0000252
has only substance units: false
boundary condition: true
is: B7Z2M9
type: Species
constant: false
name: DGKZ
is encoded by: hsa:8525
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_5af5d3c4_7034_4f7f_986a_f0dab5babac4
initial concentration: NaN
name: PIGA
is: P37287
constant: false
has only substance units: false
is encoded by: hsa:5277
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_84d7b039_cf75_4435_b608_8137dc52aa85
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:AI378339
is: SBO:0000252
name: _AI378339_1_m
boundary condition: true
constant: false

metaR CORE6GTg
is: SBO:0000176
reactant: MODEL1310110014#
name: Core 6 beta-GlcNAc-transferase A, Golgi apparatus
fast: false
notes: GENE_ASSOCIATION: (2650.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
modifier: MODEL1310110014#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.102
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reversible: false
type: Reaction

metaR GLBRAN
type: Reaction
notes: GENE_ASSOCIATION: (2632.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 2.4.1.18 Confidence Level: 4 AUTHORS: PMID:8463281 NOTES:NCD
name: 1,4-alpha-glucan branching enzyme (glygn1 -> glygn2)
product: MODEL1310110014#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.18
reversible: false
modifier: MODEL1310110014#
reactant: MODEL1310110014#

metaM na1 r
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: sodium(1+)
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00588
is: CHEBI:29101

metaM c6dc x
has only substance units: false
name: adipoyl carnitine
type: Species
boundary condition: false
constant: false
notes: FORMULA: C13H22NO6 CHARGE: -1
is: C14143
initial concentration: 1.0
initial amount: NaN
is: HMDB04047
is: SBO:0000247

metaM bilglcur e
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:57767
name: mono(glucosyluronic acid)bilirubin(2-)
initial amount: NaN
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
has only substance units: false

metaR S6T2g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110014#
modifier: MODEL1310110014#
product: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
is described by: ECO:0000000
reversible: false

metaR r1429
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
fast: false
reactant: MODEL1310110014#
name: Free diffusion
product: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#

metaM ocdececrn m
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB06351
has only substance units: false
notes: FORMULA: C25H47NO4 CHARGE: 0
initial concentration: 1.0
name: 11-octadecenoyl carnitine
type: Species
constant: false

metaR r0149
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.14.13.39
kinetic law: MODEL1310110014#
reversible: true
is: SBO:0000176
fast: false
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is described by: ECO:0000000
modifier: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_bed43c93_0634_410e_8704_019b07855914
name: FUCA1
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:2517
is: P04066
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_5686b571_0188_415a_8889_67f3f6b44009
is encoded by: hsa:8854
initial concentration: NaN
initial amount: NaN
is: F5H2Y9
name: ALDH1A2
type: Species
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR DM gncore2 g
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gncore2(g)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_3d63fe0f_4b29_4091_b9ac_5d126e9dc3a0
initial concentration: NaN
name: GCK
type: Species
is encoded by: hsa:2645
is: Q53Y25
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

metaM nh4 m
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: C01342
has only substance units: false
initial concentration: 1.0
name: Ammonium
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00051

metaM 3hdcoa m
initial amount: NaN
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
boundary condition: false
has only substance units: false
name: (S)-3-Hydroxydecanoyl-CoA
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/16019966

metaM pect e
notes: FORMULA: C2535H3509O2535 CHARGE: -1
initial amount: NaN
type: Species
name: pectins
boundary condition: false
has only substance units: false
constant: false
is: HMDB03402
initial concentration: 1.0
is: SBO:0000247

metaR UAG4E
reversible: true
is: SBO:0000176
reactant: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
modifier: MODEL1310110014#
name: UDP-N-acetylglucosamine 4-epimerase
kinetic law: MODEL1310110014#
fast: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/5.1.3.2

metaR GLYCLTtp
product: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
name: glycolate transport into peroxisome
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110014#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD

metaM c16dc e
has only substance units: false
type: Species
is: HMDB00712
boundary condition: false
constant: false
notes: FORMULA: C23H42NO6 CHARGE: -1
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: Hexadecanedioic acid mono-L-carnitine ester

metaM 3ddcrn c
type: Species
initial amount: NaN
name: 3-hydroxydodecanoylcarnitine
is: HMDB00623
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C19H37NO5 CHARGE: 0

metaM clpndcoa x
constant: false
initial amount: NaN
name: clupanodonyl CoA
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
is: http://identifiers.org/pubchem.compound/47205476
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB06267
boundary condition: false
is: C16166

http://identifiers.org/biomodels.db/MODEL1310110014#_764677ef_3630_4b9f_a5c4_1b6d62c935c6
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: EARS2
has only substance units: false
is encoded by: hsa:124454
boundary condition: true
is: Q5JPH6
constant: false

metaM mlthf m
initial amount: NaN
is: C00143
is: SBO:0000247
is: HMDB01533
initial concentration: 1.0
type: Species
is: CHEBI:15636
constant: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
boundary condition: false
has only substance units: false
name: 5,10-Methylenetetrahydrofolate

http://identifiers.org/biomodels.db/MODEL1310110014#_6a2445b8_5746_448c_897e_525185b3a0c7
boundary condition: true
constant: false
type: Species
name: NDUFS2
has only substance units: false
is encoded by: hsa:4720
is: B7Z792
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR r1428
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000000
reversible: true
product: MODEL1310110014#
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
fast: false
is: SBO:0000185
type: Reaction

metaM octd11ecoa m
is: HMDB06294
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
name: 11-octadecenoylcoa
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaM nh4 n
initial amount: NaN
is: HMDB00051
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:28938
boundary condition: false
initial concentration: 1.0
type: Species
name: ammonium
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaR CITtam
kinetic law: MODEL1310110014#
is: SBO:0000185
reversible: true
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
fast: false
is described by: ECO:0000269
name: citrate transport, mitochondrial
type: Reaction
modifier: MODEL1310110014#
reactant: MODEL1310110014#

metaM glygn3 c
name: glycogen, structure 3 (glycogenin-7[1,4-Glc])
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:15748
notes: FORMULA: C42H71O36X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02137
is: HMDB00127
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species

metaR BAMPPALDOX
type: Reaction
modifier: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.2.1.36
kinetic law: MODEL1310110014#
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
reactant: MODEL1310110014#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110014#_62084c6b_7204_4e5b_998f_76ebda6718e8
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: SLC27A1
is: SBO:0000252
is: Q6PCB7
type: Species
is encoded by: hsa:376497
constant: false
boundary condition: true

metaM gthrd m
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
name: glutathionate(1-)
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: CHEBI:57925
is: HMDB00125
type: Species
is: SBO:0000247

metaR Asn X Ser Thrtr
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
name: Asn-X-Ser/Thr transport (from ER to lysosome)
product: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
reversible: true
is described by: ECO:0000269
fast: false
is: SBO:0000185

metaR EX strch2 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_df05c8b5_45b4_441c_99f1_9488cdf2298c
type: Species
initial amount: NaN
is encoded by: hsa:AI769281
is: SBO:0000252
initial concentration: NaN
name: _AI769281_1_e
boundary condition: true
constant: false
has only substance units: false

metaM gam6p c
constant: false
initial concentration: 1.0
is: HMDB01254
is: CHEBI:12962
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
name: D-Glucosamine 6-phosphate
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352

http://identifiers.org/biomodels.db/MODEL1310110014#_4ac04d6a_039b_4ef5_9164_27258690696b
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q86T14
name: GMPR2
initial concentration: NaN
is encoded by: hsa:51292

metaR ESTRADIOLt
fast: false
name: estradiol transport
is described by: ECO:0000000
product: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110014#
is: SBO:0000185
reactant: MODEL1310110014#
reversible: true

metaM bilglcur c
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
name: mono(glucosyluronic acid)bilirubin(2-)
is: CHEBI:57767
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374

metaM man c
has only substance units: false
boundary condition: false
type: Species
name: D-Mannose
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16024
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: HMDB00169
is: C00159

metaR r1318
reversible: true
product: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110014#
fast: false
type: Reaction
kinetic law: MODEL1310110014#
name: Transport reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110014#_7ad056a8_2bd0_4d14_b1bb_1fdae6a9e509
has only substance units: false
name: HMGCLL1
is encoded by: hsa:54511
initial concentration: NaN
is: Q9NT06
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
type: Species

metaM succoa m
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
is: CHEBI:57292
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB01022
name: Succinyl-CoA
has only substance units: false
type: Species
constant: false
initial concentration: 1.0

metaR 2MB2COAc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 2-methylcrotonoyl-CoA into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_495911c1_5330_4f03_928a_3e5e885546ba
boundary condition: true
is: Q9H2X9
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:57468
initial amount: NaN
name: SLC12A5
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_8f9aefdb_97aa_4829_a2b4_7d39a0f51179
boundary condition: true
constant: false
has only substance units: false
is: P13807
is encoded by: hsa:2997
name: GYS1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species

metaR NTD10
is: SBO:0000176
name: 5'-nucleotidase (XMP)
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.5
is described by: ECO:0000254
product: MODEL1310110014#
modifier: MODEL1310110014#
reversible: false
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:15699053 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Rat
kinetic law: MODEL1310110014#
type: Reaction

metaM 3ddcrn e
is: C02838
name: 3-hydroxydodecanoylcarnitine
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C19H37NO5 CHARGE: 0
is: HMDB00791
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_metaR_EX_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1 exchange
type: Reaction

metaM tetpent3coa x
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: tetracosapentaenoyl coenzyme A, n-3
is: SBO:0000247
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1
initial amount: NaN
is: C16167
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_fffe6e98_f97a_42cf_a284_dbd51ceed628
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is: Q16635
initial amount: NaN
is encoded by: hsa:6901
name: TAZ
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_aee38a87_197b_4cf6_8bf2_25d87894cd9f
is encoded by: hsa:4705
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
name: NDUFA10
initial concentration: NaN
initial amount: NaN
is: O95299
constant: false

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR GLCter
is described by: ECO:0000000
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
kinetic law: MODEL1310110014#
name: glucose transport, endoplasmic reticulum
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110014#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_7a2278fc_8f43_47ab_a877_157e81c1282f
initial concentration: NaN
is encoded by: hsa:4710
initial amount: NaN
has only substance units: false
is: O95168
type: Species
boundary condition: true
constant: false
is: SBO:0000252
name: NDUFB4

metaR DGTPtn
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: dGTP diffusion in nucleus
is: SBO:0000185
product: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
is described by: ECO:0000000
kinetic law: MODEL1310110014#

metaM taur x
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
is: HMDB00251
boundary condition: false
name: taurine
is: CHEBI:15891

http://identifiers.org/biomodels.db/MODEL1310110014#_cf3fa050_39e5_4d0b_bf1a_293cc1b89991
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is: P48736
constant: false
boundary condition: true
has only substance units: false
name: PIK3CG
is encoded by: hsa:5294

metaR RE0453M
modifier: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
name: RE0453
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000000

metaM xylu L c
is: HMDB00751
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
type: Species
boundary condition: false
name: L-xylulose
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17399

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

metaR EX omeprazole LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: omeprazole exchange
type: Reaction

metaM hmgcoa c
initial concentration: 1.0
is: HMDB01375
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:15467
name: Hydroxymethylglutaryl-CoA
constant: false
type: Species
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356

metaR LSTO1r
reactant: MODEL1310110014#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
is version of: http://identifiers.org/ec-code/1.14.21.6
product: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#
is described by: ECO:0000269
type: Reaction
name: Lathosterol oxidase
kinetic law: MODEL1310110014#

metaR EX 34hpp
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaR 13DAMPPOX
is: SBO:0000176
reversible: false
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.4.3.22
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.4.3.21
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
product: MODEL1310110014#
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
kinetic law: MODEL1310110014#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_bc96d5c6_f0c8_440e_925c_3816f7151ee4
boundary condition: true
name: ARSB
type: Species
is encoded by: hsa:411
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is: A8K4A0

metaM ala L x
type: Species
initial concentration: 1.0
name: L-alanine
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:16977
is: HMDB00161
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial amount: NaN

metaM man e
is: C00159
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
name: D-Mannose
is: CHEBI:16024
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
type: Species
is: HMDB00169

metaR ILEt5m
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: Isoleucine mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
type: Reaction
reversible: true
fast: false
product: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000185

metaR PPDOy
kinetic law: MODEL1310110014#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.21
reactant: MODEL1310110014#
product: MODEL1310110014#
modifier: MODEL1310110014#
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
is: SBO:0000176
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2

http://identifiers.org/biomodels.db/MODEL1310110014#_9c522ee3_ea4e_4092_91d9_c8bb3fa3d0de
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
name: BLVRB
is encoded by: hsa:645
has only substance units: false
is: P30043

metaM ksi pre26 g
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
name: keratan sulfate I biosynthesis, precursor 26
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28067
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_69fb8457_5aa6_42f5_8ab7_204a3f591d72
is encoded by: hsa:1650
initial concentration: NaN
constant: false
boundary condition: true
is: P39656
initial amount: NaN
name: DDOST
is: SBO:0000252
has only substance units: false
type: Species

metaR EX 3bcrn
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy butyryl carnitine
type: Reaction

metaM HC01609 e
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
initial concentration: 1.0
name: UroporphyrinogenI
constant: false
is: CHEBI:28766
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false

metaM sarcs c
is: HMDB00271
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: Sarcosine
is: CHEBI:3513
boundary condition: false
is: C00213
notes: FORMULA: C3H7NO2 CHARGE: 0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_7e6a8fb1_13c6_4e4c_8631_1a4bc1a10508
is encoded by: hsa:6240
type: Species
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:6241
has part: P31350
initial concentration: NaN
has part: P23921
constant: false
name: RRM1:RRM2
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_070dade8_978c_469d_8729_9bf049e2eaa5
initial amount: NaN
is: B3KT70
type: Species
constant: false
is encoded by: hsa:80201
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
name: HKDC1

metaR EX pydx5p LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of pyridoxal 5-phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_b69c0a19_e2f3_4cd3_921a_096fd29a4e8f
has only substance units: false
type: Species
initial concentration: NaN
is: Q5FC00
initial amount: NaN
is: SBO:0000252
name: CA6
is encoded by: hsa:765
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_f9030108_5db0_4844_a049_bb2334581756
is: SBO:0000252
has only substance units: false
name: _728637_1_c
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:728637
boundary condition: true
initial concentration: NaN

metaR TAXOLte
kinetic law: MODEL1310110014#
type: Reaction
name: xenobiotic transport
is described by: ECO:0000000
product: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
reversible: true
fast: false

metaM tagat D e
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0
constant: false
is: CHEBI:16443
is: HMDB03418
initial concentration: 1.0
boundary condition: false
name: D-tagatose
type: Species
has only substance units: false
initial amount: NaN

metaM acrn m
is: CHEBI:57589
initial amount: NaN
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: SBO:0000247
is: HMDB00201
constant: false
has only substance units: false
boundary condition: false
name: O-acetylcarnitine
initial concentration: 1.0
type: Species

metaM HC01842 c
type: Species
name: Phosphodimethylethanolamine
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:31997
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)

http://identifiers.org/biomodels.db/MODEL1310110014#_efb114b9_c79d_414c_b424_13a1a0b19d1a
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
name: ENPP1
type: Species
is encoded by: hsa:5167
boundary condition: true
is: P22413
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_427c6770_3888_4ac2_a6d0_6625a076af96
initial amount: NaN
initial concentration: NaN
is: B4DK61
is: SBO:0000252
type: Species
constant: false
name: ACOX1
boundary condition: true
has only substance units: false
is encoded by: hsa:51

metaM h2o2 e
initial concentration: 1.0
is: CHEBI:16240
type: Species
name: hydrogen peroxide
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB03125

metaR PPDOx
modifier: MODEL1310110014#
fast: false
type: Reaction
kinetic law: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD
is: SBO:0000176
product: MODEL1310110014#
name: Propane-1,2-diol:NAD+ 1-oxidoreductase
reactant: MODEL1310110014#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110014#_47e851bc_a79b_4240_8506_0133176494ae
has only substance units: false
constant: false
initial concentration: NaN
name: SLC24A4
is encoded by: hsa:123041
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_d09a8ae0_1904_4e2b_a127_efb1be275f6f
boundary condition: true
is encoded by: hsa:9057
has part: Q92536
initial concentration: NaN
is: SBO:0000297
has only substance units: false
name: SLC3A2:SLC7A6
constant: false
initial amount: NaN
type: Species

metaM c226coa m
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: C16169
name: cervonyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205479
is: SBO:0000247

metaM glyc3p m
boundary condition: false
is: C00093
initial amount: NaN
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00126
initial concentration: 1.0
is: CHEBI:57597
name: Glycerol 3-phosphate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_8a1eb073_a3b8_4b36_a5b9_bba6985e1188
has only substance units: false
name: DLAT
is: Q86YI5
is encoded by: hsa:1737
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial concentration: NaN

metaR ACOAD1fm
reversible: false
modifier: MODEL1310110014#
fast: false
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
product: MODEL1310110014#
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaR ATP2ter
is described by: ECO:0000000
product: MODEL1310110014#
type: Reaction
reversible: true
reactant: MODEL1310110014#
name: AMP/ATP transporter, endoplasmic reticulum
is: SBO:0000185
kinetic law: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaM man g
type: Species
initial amount: NaN
constant: false
name: D-mannose
is: HMDB00169
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: SBO:0000247
boundary condition: false
is: CHEBI:16024

metaR FAOXC2242046x
product: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110014#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
reversible: false
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.3.3.6

metaM gdpddman c
is: CHEBI:57964
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222
type: Species
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01346

metaR GALASE17ly
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110014#
is: SBO:0000176
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110014#
is described by: ECO:0000000
fast: false
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
reversible: false

metaM ksi pre15 g
boundary condition: false
has only substance units: false
is: C00130
initial concentration: 1.0
type: Species
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
name: keratan sulfate I biosynthesis, precursor 15
initial amount: NaN
is: SBO:0000247
is: CHEBI:58053
is: HMDB00175
constant: false

metaM stcoa x
has only substance units: false
is: HMDB01114
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:57394
initial amount: NaN
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: C00412
type: Species
is: SBO:0000247
name: Stearoyl-CoA (n-C18:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110014#_42bf6499_174b_4090_9b0f_55a3f83670b3
name: _AI291895_1_c
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:AI291895
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_e560ed5e_27c4_4337_96bb_90abd0468593
is encoded by: hsa:2180
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P33121
name: ACSL1
initial amount: NaN
type: Species
boundary condition: true

metaM ksii core4 pre6 g
name: keratan sulfate II biosynthesis, precursor 6
constant: false
initial amount: NaN
is: CHEBI:28067
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C69H111N6O51SX CHARGE: -2
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_58de4f29_9fd2_460f_aaca_073b9a4fd2e2
is encoded by: hsa:2650
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: GCNT1
boundary condition: true
is: Q02742

http://identifiers.org/biomodels.db/MODEL1310110014#_19d1c221_754c_43fc_bd21_7472530efd89
name: B3GNT8
initial amount: NaN
constant: false
initial concentration: NaN
is: Q7Z7M8
is encoded by: hsa:374907
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_783334cd_2ac5_4612_9db7_e39e2999fd1b
name: IVD
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:3712
is: SBO:0000252
constant: false
has only substance units: false
is: B3KVI7
type: Species

metaR O2t
product: MODEL1310110014#
kinetic law: MODEL1310110014#
name: o2 transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
reactant: MODEL1310110014#
type: Reaction
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000

metaM c16dc c
is: HMDB00712
notes: FORMULA: C23H42NO6 CHARGE: -1
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
boundary condition: false
name: Hexadecanedioic acid mono-L-carnitine ester
initial concentration: 1.0
has only substance units: false

metaM sbcoa x
has only substance units: false
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
initial amount: NaN
boundary condition: false
name: suberylcoa
is: http://identifiers.org/pubchem.compound/16019966
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0

metaM h2o2 c
initial concentration: 1.0
is: HMDB03125
is: CHEBI:16240
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
constant: false
initial amount: NaN
is: SBO:0000247
name: Hydrogen peroxide
is: C00027

metaR FACOAL244 1
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reversible: true
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
reactant: MODEL1310110014#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_7f8d8abb_a117_41c6_aba3_dc5b4109ed31
boundary condition: true
constant: false
initial amount: NaN
is: O75438
has only substance units: false
name: NDUFB1
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:4707

http://identifiers.org/biomodels.db/MODEL1310110014#_199af70e_d19f_48a7_b15c_1c483d8d0286
initial amount: NaN
name: PIP5K1B
is: O14986
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:8395
boundary condition: true

metaM pppg9 m
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
type: Species
initial amount: NaN
constant: false
is: CHEBI:57307
is: HMDB01097
name: Protoporphyrinogen IX
is: C01079
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaM HC00695 m
initial concentration: 1.0
boundary condition: false
name: S-Succinyldihydrolipoamide
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
type: Species
is: CHEBI:17432

http://identifiers.org/biomodels.db/MODEL1310110014#_b74d84de_0baf_4b99_96df_afdb9d7e7e33
has only substance units: false
is: SBO:0000252
name: ST3GAL3
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:6487
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_7abdaf90_af49_4e72_b816_d371fe7e7d0b
has only substance units: false
initial amount: NaN
is encoded by: hsa:1645
initial concentration: NaN
name: AKR1C1
is: Q04828
is: SBO:0000252
type: Species
boundary condition: true
constant: false

metaR r2092
is described by: ECO:0000000
fast: false
product: MODEL1310110014#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110014#
is: SBO:0000185
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_ea63ccb0_75e4_46f3_96dd_e4466cd18723
constant: false
is encoded by: hsa:4645
name: MYO5B
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: Q9H6Y6
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_8820d72a_eaf5_4c4e_8e07_574c121f4dc1
boundary condition: true
type: Species
name: MTMR1
is encoded by: hsa:8776
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q13613

http://identifiers.org/biomodels.db/MODEL1310110014#_7030dd1b_140b_45cf_a108_35d5b5291d42
type: Species
is: Q9NY65
is encoded by: hsa:1962
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: EHHADH
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_3f071222_2e23_4a9a_a82d_823c090fdfba
initial amount: NaN
is encoded by: hsa:7001
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
name: PRDX2

metaR CRNrtx
reactant: MODEL1310110014#
name: reversible transport of L-Carnitine in peroxisome
kinetic law: MODEL1310110014#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
fast: false
is: SBO:0000185
is described by: ECO:0000134
product: MODEL1310110014#

metaR r0142
reactant: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
is: SBO:0000176
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
modifier: MODEL1310110014#
is described by: ECO:0000000
fast: false
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110014#_101bb08a_fa49_4ed8_9f04_574f5e986a77
type: Species
is encoded by: hsa:286297
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
name: _286297_1_c
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_metaM_fucgalacglc13galacglcgal14acglcgalgluside_hs_g
is: HMDB00257
has only substance units: false
type: Species
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C78H135N4O46FULLRCO CHARGE: 0
is: CHEBI:16094
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)1 (Cer)1
initial amount: NaN
initial concentration: 1.0

metaR r1721
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
is: SBO:0000185
product: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0497
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.2.4.2
modifier: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
reversible: true
type: Reaction
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_67750ff8_f4d8_4e37_8ec2_6a24ffa988a2
initial concentration: NaN
is: Q15392
name: DHCR24
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:1718
type: Species

metaR r0792
reactant: MODEL1310110014#
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110014#
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
fast: false

metaR r1646
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110014#
product: MODEL1310110014#
fast: false
reversible: true

metaM ksi pre31 g
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 31
is: CHEBI:58053
has only substance units: false
is: C00130
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
type: Species
boundary condition: false
is: HMDB00175
constant: false
is: SBO:0000247

metaM amet c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: HMDB01185
has only substance units: false
initial concentration: 1.0
constant: false
is: C00019
initial amount: NaN
is: CHEBI:15414
type: Species
name: S-Adenosyl-L-methionine

metaR r2093
reactant: MODEL1310110014#
is: SBO:0000185
product: MODEL1310110014#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
kinetic law: MODEL1310110014#
fast: false
modifier: MODEL1310110014#

metaR ASPGLUm
notes: GENE_ASSOCIATION: (8604.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reactant: MODEL1310110014#
product: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110014#
name: aspartate-glutamate mitochondrial shuttle

metaM dmnoncoa m
has only substance units: false
constant: false
is: HMDB11604
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
boundary condition: false
is: SBO:0000247
name: 4,8 dimethylnonanoyl-CoA

metaR r1936
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110014#
fast: false
name: Y+LAT2 Utilized transport
reversible: false
modifier: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000185

metaM limnen c
initial concentration: 1.0
notes: FORMULA: C10H16 CHARGE: 0 INCHI: InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4,10H,1,5-7H2,2-3H3
name: limonene
is: SBO:0000247
has only substance units: false
is: CHEBI:15384
constant: false
type: Species
initial amount: NaN
is: HMDB03375
boundary condition: false

metaR SUCCt2m
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
fast: false
is: SBO:0000185
type: Reaction
name: succinate transport, mitochondrial
product: MODEL1310110014#
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_4a3fd755_4c4b_4fe0_bd54_d49f3192cb78
is: O14521
name: SDHD
constant: false
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:6392
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM ttdcrn m
type: Species
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
constant: false
is: HMDB05066
boundary condition: false
name: tetradecanoyl carnitine
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3413344
initial amount: NaN

metaM strdnccoa m
name: stearidonyl coenzyme A
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: http://identifiers.org/pubchem.compound/47205473
has only substance units: false
boundary condition: false
is: HMDB06519
initial concentration: 1.0
is: C16163
is: SBO:0000247
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_c9adb286_1559_4553_9e51_00d2907b67ea
boundary condition: true
is encoded by: hsa:210
is: Q6ZMU0
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: ALAD
type: Species
is: SBO:0000252

metaR ASCBt
reactant: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
fast: false
name: L-ascorbate transport via facilitated diffusion
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110014#
reversible: true

metaM glcur e
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15748
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00127
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
name: D-glucuronate

http://identifiers.org/biomodels.db/MODEL1310110014#_cd5e81a8_5862_45a7_8346_a18c9be5127f
is encoded by: hsa:4351
boundary condition: true
has only substance units: false
is: P34949
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
name: MPI

metaR CYTK9
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110014#
is described by: ECO:0000269
reversible: true
product: MODEL1310110014#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,dCTP)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_5597e973_7009_4a25_92a9_e677b1b79b36
type: Species
initial concentration: NaN
name: ASS1
is: P00966
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:445
boundary condition: true
is: SBO:0000252

metaM thbpt4acam c
is: CHEBI:15374
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: 4a-hydroxytetrahydrobiopterin
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: HMDB02281

metaR r0791
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_0b80e97d_402b_42da_83c4_0fe5f0b6d1b6
initial amount: NaN
name: BAAT
is: Q14032
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:570

metaR r1647
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
product: MODEL1310110014#
type: Reaction
modifier: MODEL1310110014#
is: SBO:0000185

metaM stcoa m
is: HMDB01114
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57394
has only substance units: false
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: C00412
name: Stearoyl-CoA (n-C18:0CoA)
type: Species

metaR r2094
fast: false
type: Reaction
reactant: MODEL1310110014#
is: SBO:0000185
product: MODEL1310110014#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: true
is described by: ECO:0000000

metaR NAIt
type: Reaction
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
fast: false
is: SBO:0000185
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true
modifier: MODEL1310110014#
is described by: ECO:0000269
name: Na+ / iodide cotransport

metaR GALASE3ly
product: MODEL1310110014#
fast: false
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110014#
type: Reaction
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110014#
reversible: false

metaR SARCStm
name: Sarcosine transport (mitochondrial)
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
product: MODEL1310110014#
fast: false
reactant: MODEL1310110014#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_3dd55f40_5f4e_43fb_8dd3_542d1e11564d
initial concentration: NaN
is: A6NED0
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:2954
is: SBO:0000252
type: Species
name: GSTZ1

metaR NACHEX15ly
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110014#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#

metaR CYTK8
modifier: MODEL1310110014#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,dATP)
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
product: MODEL1310110014#

metaM decdicoa c
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB01168
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: decadienoylcoa

metaM htaxol e
has only substance units: false
is: HMDB02259
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:32366
initial concentration: 1.0
name: 6 alpha hydroxy taxol/ 6 alpha hydroxy paclitaxel
constant: false
type: Species
notes: FORMULA: C47H31NO15 CHARGE: 0 INCHI: InChI=1/C47H51NO15/c1-24-30(61-43(57)33(51)32(27-16-10-7-11-17-27)48-41(55)28-18-12-8-13-19-28)22-47(58)40(62-42(56)29-20-14-9-15-21-29)36-45(6,38(54)35(60-25(2)49)31(24)44(47,4)5)37(53)34(52)39-46(36,23-59-39)63-26(3)50/h7-21,30,32-37,39-40,51-53,58H,22-23H2,1-6H3,(H,48,55)/t30-,32-,33+,34-,35+,36-,37-,39+,40-,45+,46-,47-/m1/s1

metaR r1648
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110014#
reversible: true

metaM tagat D c
is: HMDB03418
notes: FORMULA: C6H12O6 CHARGE: 0
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:16443
has only substance units: false
constant: false
boundary condition: false
name: D-tagatose

metaM inost e
is: SBO:0000247
initial concentration: 1.0
is: HMDB00211
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
boundary condition: false
name: myo-inositol
has only substance units: false
is: CHEBI:17268
constant: false
type: Species

metaM 3mox4hoxm m
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
is: SBO:0000247
type: Species
is: CHEBI:27622
constant: false
boundary condition: false
is: HMDB00291
name: 3-Methoxy-4-hydroxymandelate
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM h2o2 x
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB03125
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: C00027
constant: false
has only substance units: false
name: Hydrogen peroxide
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_8ac4d6e6_0b30_4ee4_a899_da1a5b3e4e63
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaM dhcrm hs c
is: CHEBI:31488
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
initial amount: NaN
is: SBO:0000247
name: dihydroceramide
type: Species

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR SACCD4m
kinetic law: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.10 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
is version of: http://identifiers.org/ec-code/1.5.1.8
modifier: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
is described by: ECO:0000269
is: SBO:0000176
reversible: false
name: saccharopine dehydrogenase (NAD, L-glutamate forming), mitochondrial
product: MODEL1310110014#

metaR r2095
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110014#
product: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110014#_41a74e7e_9710_4abb_ac12_c1b3cc76c741
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is: Q59E93
initial amount: NaN
name: ANPEP
has only substance units: false
is encoded by: hsa:290
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_4e529bcc_abc1_4e33_974b_f3aac74ee05d
constant: false
boundary condition: true
name: NDUFA13
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9P0J0
initial concentration: NaN
has only substance units: false
is encoded by: hsa:51079

metaR G14Tg
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110014#
type: Reaction
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000269

metaR FATP4t
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: true
name: fatty acid electroneutral transport
notes: GENE_ASSOCIATION: (10998.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
fast: false
reactant: MODEL1310110014#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.7

metaM eicostetcoa c
type: Species
name: eicosatetranoyl coenzyme A
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
is: C16164
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_479b8957_f650_44b1_90b7_ccfb1242a296
is: SBO:0000252
constant: false
is: P07954
name: FH
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2271
boundary condition: true
has only substance units: false

metaM tmndnc c
is: SBO:0000247
is: HMDB01999
name: timnodonic acid C20:5, n-3
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/446284
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
constant: false

metaM gudac c
is: HMDB00128
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H7N3O2 CHARGE: 0 INCHI: InChI=1S/C3H7N3O2/c4-3(5)6-1-2(7)8/h1H2,(H,7,8)(H4,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00439 EHMN_ABBREVIATION: C00581
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:16344
initial amount: NaN
name: guanidinoacetic acid
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_26d00c85_dbb9_4b3a_9a93_a42452293db7
name: AK2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:204
constant: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_5933a338_a18b_4dc9_9423_d9a635c098e0
boundary condition: true
initial concentration: NaN
has only substance units: false
name: GALNT1
initial amount: NaN
is encoded by: hsa:2589
is: SBO:0000252
is: Q10472
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_1eb20367_5dce_416c_9457_74583e8cd6b2
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
name: PIPOX
type: Species
is: Q9P0Z9
is encoded by: hsa:51268
initial amount: NaN

metaR MALtm
is: SBO:0000185
fast: false
name: malate transport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
type: Reaction
modifier: MODEL1310110014#
reversible: true
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000269

metaR DURAD
product: MODEL1310110014#
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.1.2
type: Reaction
is: SBO:0000176
name: dihydrouracil dehydrogenase (NADP)
fast: false
modifier: MODEL1310110014#
reversible: true

metaM gdp c
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
has only substance units: false
boundary condition: false
name: GDP
is: C00035
initial concentration: 1.0
is: SBO:0000247
is: HMDB01201
type: Species
is: CHEBI:58189
initial amount: NaN
constant: false

metaM 2dr5p c
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
initial amount: NaN
name: 2-deoxy-D-ribose 5-phosphate(2-)
is: SBO:0000247
boundary condition: false
is: CHEBI:57651
is: HMDB01031
constant: false

metaR PRO Dtde
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
reactant: MODEL1310110014#
is: SBO:0000185
kinetic law: MODEL1310110014#
fast: false
name: D-proline transport, extracellular
reversible: true
is described by: ECO:0000134
type: Reaction
product: MODEL1310110014#

metaR CYTK7
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,UTP)
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000176
reactant: MODEL1310110014#
type: Reaction
fast: false
reversible: true
product: MODEL1310110014#
is described by: ECO:0000269

metaR r1649
reactant: MODEL1310110014#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110014#
type: Reaction
modifier: MODEL1310110014#
is: SBO:0000185
fast: false
reversible: true

metaM 4hexdtricoa x
name: 4,7,10-hexadecatrienoylcoa
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB02288
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C37H56N7O17P3S CHARGE: -4

metaR r1725
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110014#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110014#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110014#_113784d2_1f56_4340_9218_db45c893cd70
name: COX6A2
initial concentration: NaN
is: Q02221
is encoded by: hsa:1339
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_fcf5f8b8_02c1_4f64_bbd4_1f4025cc23ff
has only substance units: false
type: Species
boundary condition: true
is: Q8TDB8
initial amount: NaN
is: SBO:0000252
name: SLC2A14
constant: false
is encoded by: hsa:144195
initial concentration: NaN

metaM htaxol c
name: 6 alpha hydroxy taxol/ 6 alpha hydroxy paclitaxel
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:28815
constant: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C47H31NO15 CHARGE: 0 INCHI: InChI=1/C47H51NO15/c1-24-30(61-43(57)33(51)32(27-16-10-7-11-17-27)48-41(55)28-18-12-8-13-19-28)22-47(58)40(62-42(56)29-20-14-9-15-21-29)36-45(6,38(54)35(60-25(2)49)31(24)44(47,4)5)37(53)34(52)39-46(36,23-59-39)63-26(3)50/h7-21,30,32-37,39-40,51-53,58H,22-23H2,1-6H3,(H,48,55)/t30-,32-,33+,34-,35+,36-,37-,39+,40-,45+,46-,47-/m1/s1

metaM prpncoa m
name: acryloyl-CoA(4-)
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:57367
is: HMDB02307
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_e367bd43_5366_4856_ab01_91b9d1fc6b88
is encoded by: hsa:51109
boundary condition: true
initial amount: NaN
constant: false
is: B4DDW0
is: SBO:0000252
type: Species
initial concentration: NaN
name: RDH11
has only substance units: false

metaR UMPK6n
reversible: true
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
name: UMP kinase (dCTP),nuclear
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reactant: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is described by: ECO:0000269

metaR SEBACACT
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of sebacic acidd
type: Reaction

metaR NDP3ex
name: nucleoside-diphosphatase (GDP), extracellular
product: MODEL1310110014#
is described by: ECO:0000269
modifier: MODEL1310110014#
reversible: false
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.6.1.6
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
fast: false

metaM inost c
is: HMDB00211
initial amount: NaN
name: myo-inositol
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:17268

metaR CYTK6
reactant: MODEL1310110014#
name: cytidylate kinase (CMP,CTP)
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110014#
product: MODEL1310110014#
modifier: MODEL1310110014#
fast: false

metaR r0796
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110014#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110014#
reversible: true
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
kinetic law: MODEL1310110014#
type: Reaction

metaM m4masn g
type: Species
has only substance units: false
notes: FORMULA: C46H77N2O35X CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: C05881
boundary condition: false
initial amount: NaN
constant: false

metaM for e
is: CHEBI:15740
is: SBO:0000247
name: formate
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: HMDB00142

http://identifiers.org/biomodels.db/MODEL1310110014#_94cabad7_c3d8_44b0_a37c_f3a3b47c03f0
has only substance units: false
boundary condition: true
is encoded by: hsa:6480
name: ST6GAL1
initial concentration: NaN
is: B2R513
is: SBO:0000252
type: Species
constant: false
initial amount: NaN

metaR FAOXC5OHc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: (3-hydroxyisovalerylcoa-->3-hydroxyisovalerylcarnitine)c
type: Reaction

metaR FAOXTC122TC101m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C12:2-->C10:1)m
type: Reaction

metaR r0145
kinetic law: MODEL1310110014#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
modifier: MODEL1310110014#
is described by: ECO:0000000
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.8.3.1
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
fast: false
reversible: true

metaR ALR3
is version of: http://identifiers.org/ec-code/1.1.1.21
is: SBO:0000176
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110014#
reactant: MODEL1310110014#
reversible: false
name: aldose reductase (acetol)
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD

metaR CYTK4
type: Reaction
modifier: MODEL1310110014#
is described by: ECO:0000269
name: cytidylate kinase (dCMP)(GTP)
product: MODEL1310110014#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
fast: false

metaR ACTNMO
product: MODEL1310110014#
fast: false
is described by: ECO:0000269
reversible: false
type: Reaction
name: acetone monooxygenase
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1571.1) SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:stoichiometry described in Thornalley PJ. Gen Pharmacol. 1996 Jun;27(4):565-73. PMID: 8853285 NCD

metaR RE2759X
name: RE2759
type: Reaction
product: MODEL1310110014#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/5.1.99.4
notes: GENE_ASSOCIATION: (23600.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:11060344,PMID:11060359 NOTES:
reactant: MODEL1310110014#
is described by: ECO:0000000
modifier: MODEL1310110014#
fast: false

metaR CYTK5
is described by: ECO:0000269
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110014#
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110014#
fast: false
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP)

http://identifiers.org/biomodels.db/MODEL1310110014#_9529aee5_09ed_4dbf_a20c_ffce9dde8c47
is: P20020
is encoded by: hsa:490
name: ATP2B1
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaR r0795
reactant: MODEL1310110014#
reversible: false
product: MODEL1310110014#
modifier: MODEL1310110014#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.225
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Unassigned EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
name: Spontaneous reaction
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110014#

metaM tmndnc e
boundary condition: false
constant: false
is: HMDB01999
name: timnodonic acid C20:5, n-3
is: http://identifiers.org/pubchem.compound/446284
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-

metaM pppg9 c
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
type: Species
name: Protoporphyrinogen IX
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C01079
is: HMDB01097
initial amount: NaN
is: CHEBI:57307
boundary condition: false

metaR A4GALTg
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.228
is described by: ECO:0000269
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
reversible: false
fast: false
type: Reaction
product: MODEL1310110014#
name: Lactosylceramide 4-alpha-galactosyltransferase
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_b303ff96_04cf_498a_9482_bfb022539a23
is encoded by: hsa:U52111
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: _U52111_1_c
type: Species

metaM acrn c
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
type: Species
name: O-acetylcarnitine
is: SBO:0000247
initial amount: NaN
is: CHEBI:57589
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00201
constant: false

metaR CYTK3
is described by: ECO:0000269
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.4.3
modifier: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
is: SBO:0000176
reversible: true
fast: false
name: cytidylate kinase (CMP)(GTP)
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:

metaR ALR2
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.1.1.21
is version of: http://identifiers.org/ec-code/1.1.1.2
fast: false
name: aldose reductase (methylglyoxal)
product: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#

metaR CITtbm
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
modifier: MODEL1310110014#
is described by: ECO:0000269
reversible: true
type: Reaction
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: citrate transport, mitochondrial
product: MODEL1310110014#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110014#_b7966a88_5ac8_44ac_89c9_2679156db15a
initial amount: NaN
type: Species
has only substance units: false
is: G3V5N0
constant: false
is encoded by: hsa:2530
initial concentration: NaN
boundary condition: true
name: FUT8
is: SBO:0000252

metaR SPC HSt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
product: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110014#
reversible: true
fast: false
reactant: MODEL1310110014#
name: sphingosylphosphorylcholine transport (diffusion)
type: Reaction

metaR DGULND
kinetic law: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
name: dehydro-L-gulonate decarboxylase
type: Reaction
fast: false
is: SBO:0000176
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110014#

metaM subeac c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H12O4 CHARGE: -2
is: HMDB00893
initial amount: NaN
type: Species
constant: false
name: suberic acid
boundary condition: false
is: SBO:0000247

metaR MALTe
is version of: http://identifiers.org/ec-code/3.2.1.20
reversible: false
fast: false
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (8972.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:3143729 NOTES:IF
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000269
name: alpha-glucosidase, extracellular
type: Reaction
reactant: MODEL1310110014#
is: SBO:0000176

metaM 7thf e
initial amount: NaN
boundary condition: false
is: HMDB06559
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C49H57N13O24 CHARGE: -8
name: heptaglutamyl folate (THF)
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_5ab8ca35_d32c_4a3c_aad1_580427b73f87
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is: Q15392
name: DHCR24
is encoded by: hsa:1718
initial concentration: NaN
constant: false

metaM doco13ecoa x
is: http://identifiers.org/pubchem.compound/24892791
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
name: 13-docosenoylcoa
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
boundary condition: false

metaR HISCAT1
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaM for c
is: CHEBI:15740
is: HMDB00142
has only substance units: false
is: C00058
is: SBO:0000247
type: Species
name: Formate
initial concentration: 1.0
constant: false
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_6634387e_a4ef_4f90_8a6b_c0e5d6ddf0a8
type: Species
is encoded by: hsa:570
has only substance units: false
is: Q14032
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: BAAT

metaR IDOAASE1ly
reactant: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
modifier: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000176
name: alpha-L-iduronidase, lysosomal
kinetic law: MODEL1310110014#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.76
fast: false
type: Reaction

metaR RAI3
reversible: true
notes: GENE_ASSOCIATION: (2944.1) or (2944.2) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811,PMID:9677409,PMID:9806904 NOTES:IT
type: Reaction
reactant: MODEL1310110014#
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.5.1.18
is: SBO:0000176
product: MODEL1310110014#
name: 13-cis-retinoic acid isomerase

metaM c226coa x
initial amount: NaN
has only substance units: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
boundary condition: false
is: SBO:0000247
name: cervonyl coenzyme A
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205479
is: C16169
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_a4a8bf25_843f_4c7a_b0ba_53af2af1047b
type: Species
has only substance units: false
is encoded by: hsa:11136
initial amount: NaN
is: P82251
is: SBO:0000252
name: SLC7A9
initial concentration: NaN
constant: false
boundary condition: true

metaR NACHEX18ly
kinetic law: MODEL1310110014#
fast: false
is described by: ECO:0000000
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_6b797c92_7e37_48e1_80e3_a65691f63966
has only substance units: false
type: Species
is: P78382
initial concentration: NaN
is encoded by: hsa:10559
constant: false
name: SLC35A1
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM HC00229 e
boundary condition: false
has only substance units: false
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
initial amount: NaN
is: CHEBI:28189
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
name: Isomaltose

metaR P45027A14m
kinetic law: MODEL1310110014#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110014#
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: false
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
name: 5-beta-cytochrome P450, family 27, subfamily A, polypeptide 1
is: SBO:0000176
product: MODEL1310110014#

metaR ALCD2if
notes: GENE_ASSOCIATION: (125.1 and 126.1) or (137872.1) or (125.1 and 124.1) or (127.1) or (130.1) or (284273.1) or (126.1) or (124.1) or (128.1) or (125.1) or (126.1) or (284273.2) or (131.1) or (126.1 and 124.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:11762128,PMID:12592711 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.99.24
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110014#
fast: false
name: alcohol dehydrogenase, forward rxn (ethanol -> acetaldehyde)
modifier: MODEL1310110014#

metaR r2091
product: MODEL1310110014#
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_8013fb8c_054e_477a_a44d_a280d05fdad8
boundary condition: true
is: SBO:0000252
name: INPP5J
has only substance units: false
type: Species
is: Q15735
initial amount: NaN
is encoded by: hsa:27124
initial concentration: NaN
constant: false

metaR CYTK2
fast: false
product: MODEL1310110014#
type: Reaction
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110014#
is: SBO:0000176
reactant: MODEL1310110014#
name: cytidylate kinase (dCMP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110014#

metaM limnen e
type: Species
constant: false
has only substance units: false
notes: FORMULA: C10H16 CHARGE: 0 INCHI: InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4,10H,1,5-7H2,2-3H3
name: limonene
initial concentration: 1.0
is: HMDB03375
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:15384

metaR r0797
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110014#
fast: false
reversible: true
modifier: MODEL1310110014#
type: Reaction
name: glycine N-choloyltransferase EC:2.3.1.65
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
reactant: MODEL1310110014#

metaM prostgi2 r
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:57403
type: Species
boundary condition: false
is: HMDB01335
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin I2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312

metaM fe2 m
initial amount: NaN
initial concentration: 1.0
is: HMDB00692
constant: false
type: Species
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: CHEBI:29033
is: SBO:0000247
boundary condition: false
has only substance units: false
name: Fe2+
is: C00023

metaM glyc3p c
is: C00093
is: HMDB00126
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: SBO:0000247
is: CHEBI:57597
name: Glycerol 3-phosphate

metaR r2090
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000185
product: MODEL1310110014#
reversible: true
reactant: MODEL1310110014#
is described by: ECO:0000000
type: Reaction

metaM hpyr x
is: HMDB01352
constant: false
is: CHEBI:17180
has only substance units: false
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: 3-hydroxypyruvate

http://identifiers.org/biomodels.db/MODEL1310110014#_bb62e8d5_c6ea_440c_bb4e_3567fb2fd1ae
is encoded by: hsa:2878
constant: false
initial concentration: NaN
boundary condition: true
is: P22352
initial amount: NaN
type: Species
name: GPX3
is: SBO:0000252
has only substance units: false

metaM tetpent3coa c
has only substance units: false
initial amount: NaN
is: C16167
name: tetracosapentaenoyl coenzyme A, n-3
is: SBO:0000247
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1
boundary condition: false
constant: false
initial concentration: 1.0
type: Species

metaR r0494
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
kinetic law: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
reversible: true

metaR TCHOLAtx
is: SBO:0000185
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
product: MODEL1310110014#
name: bile acid intracellular transport
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_cd9b7e10_550b_48bc_9645_29914fd4625d
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
name: BCAT1
type: Species
is: SBO:0000252
is: P54687
is encoded by: hsa:586
initial concentration: NaN

metaR MI13PP
reversible: false
product: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
type: Reaction
name: inositol-1,3-bisphosphate 3-phosphatase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110014#_d933a8c9_13bf_4d88_a43b_95bc67edad76
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:134526
has only substance units: false
type: Species
name: ACOT12
is: Q5FWE9
initial amount: NaN
boundary condition: true

metaR FADtx
product: MODEL1310110014#
kinetic law: MODEL1310110014#
name: FAD transporter, peroxisomal
fast: false
reactant: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
type: Reaction
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110014#_dff70d5e_ee58_4eb7_9117_0058a29ed8af
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5092
constant: false
name: PCBD1
has only substance units: false
boundary condition: true
is: P61457
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_a20a691e_5502_4895_bd9e_a9a95d0c5607
boundary condition: true
initial amount: NaN
is encoded by: hsa:8310
type: Species
is: SBO:0000252
is: O15254
initial concentration: NaN
constant: false
has only substance units: false
name: ACOX3

metaR CYTK1
reactant: MODEL1310110014#
product: MODEL1310110014#
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reversible: true
fast: false
name: cytidylate kinase (CMP)

http://identifiers.org/biomodels.db/MODEL1310110014#_039d6dba_4888_48ea_9365_b83118034a61
initial concentration: NaN
name: DHCR7
is encoded by: hsa:1717
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is: Q9UBM7

metaM 3ttetddcoacrn c
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
is: SBO:0000247
has only substance units: false
is: HMDB02014
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C21H37NO5 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110014#_c97f9da9_859d_433d_878e_5605d96c9a98
boundary condition: true
is encoded by: hsa:5298
initial concentration: NaN
is: Q9UBF8
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
name: PI4KB

http://identifiers.org/biomodels.db/MODEL1310110014#_c5a98560_8cc5_42e5_b92a_b32680a34027
is: Q11203
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6487
initial concentration: NaN
type: Species
boundary condition: true
name: ST3GAL3

metaR ADPCOAPTE
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of adipoyl coA for release into cytosol
type: Reaction

metaM thbpt c
name: 5,6,7,8-tetrahydrobiopterin
type: Species
is: CHEBI:15372
constant: false
is: SBO:0000247
is: HMDB00027
has only substance units: false
boundary condition: false
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
initial amount: NaN
initial concentration: 1.0

metaR SERPT
fast: false
reactant: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.50
is described by: ECO:0000269
reversible: false
name: serine C-palmitoyltransferase
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110014#
type: Reaction
is: SBO:0000176

metaR KCCt
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
product: MODEL1310110014#
name: K+-Cl- cotransport
modifier: MODEL1310110014#
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110014#
is: SBO:0000185
fast: false
reactant: MODEL1310110014#

metaM 3spyr c
is: SBO:0000247
initial concentration: 1.0
is: HMDB04045
initial amount: NaN
is: CHEBI:57940
has only substance units: false
boundary condition: false
name: 3-sulfonatopyruvate(2-)
constant: false
type: Species
notes: FORMULA: C3H2O6S CHARGE: -2 INCHI: InChI=1S/C3H4O6S/c4-2(3(5)6)1-10(7,8)9/h1H2,(H,5,6)(H,7,8,9)/p-2 EHMN_ABBREVIATION: C05528

metaR 4NPHSULT
reactant: MODEL1310110014#
is described by: ECO:0000269
reversible: false
name: 4-Nitrophenol Sulfotransferase
fast: false
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.8.2.1
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110014#
product: MODEL1310110014#

metaR LINKDEG4ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
fast: false
reactant: MODEL1310110014#
name: degradation of proteoglycan linkage region, lysosomal
is: SBO:0000176
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000000
reversible: false
type: Reaction

metaM o2s x
is: HMDB02168
has only substance units: false
is: SBO:0000247
is: CHEBI:18421
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
name: superoxide
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
boundary condition: false

metaR GALASE11ly
product: MODEL1310110014#
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110014#
type: Reaction
fast: false
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4

http://identifiers.org/biomodels.db/MODEL1310110014#_320dd217_88c0_429c_a29e_72a7430662ae
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:AI926493
initial amount: NaN
boundary condition: true
name: _AI926493_1_m
is: SBO:0000252

metaM 6pgc r
boundary condition: false
is: HMDB01316
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
type: Species
name: 6-phosphonatooxy-D-gluconate
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58759
initial amount: NaN

metaM ala L c
is: CHEBI:16977
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: HMDB00161
boundary condition: false
name: L-alanine
initial amount: NaN
has only substance units: false

metaR RE1845X
is: SBO:0000176
reactant: MODEL1310110014#
fast: false
type: Reaction
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
reversible: true
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
name: RE1845
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000000

metaR RE1531M
is: SBO:0000176
kinetic law: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110014#
name: RE1531
reactant: MODEL1310110014#
fast: false
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

metaR FACOAL200
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
reactant: MODEL1310110014#
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110014#
product: MODEL1310110014#
modifier: MODEL1310110014#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_c7878c61_65b3_4c47_a791_24b26c0bd4a2
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
name: SLC8A3
initial amount: NaN
is encoded by: hsa:6547
type: Species

metaR 3AIBTm
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
name: L-3-aminoisobutyrate transaminase, mitochondrial
modifier: MODEL1310110014#
fast: false
type: Reaction
is described by: ECO:0000304
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.6.1.19
reactant: MODEL1310110014#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110014#_5c10c323_b8ea_4ae9_90df_ad0077698170
has only substance units: false
is encoded by: hsa:492
name: ATP2B3
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q16720
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_66b58bb9_acf2_4f91_bc2b_9353e6b24827
name: AUH
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
boundary condition: true
is: Q13825
is encoded by: hsa:549
initial amount: NaN

metaR ADRNCPT1
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine O-palmitoyltransferase
kinetic law: MODEL1310110014#
is: SBO:0000176
product: MODEL1310110014#
type: Reaction
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false

metaR G14T19g
reactant: MODEL1310110014#
reversible: false
product: MODEL1310110014#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110014#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110014#_7b90b456_d154_4877_9846_4d6e8a541ec0
initial amount: NaN
has only substance units: false
is: Q9UNU6
initial concentration: NaN
name: CYP8B1
is encoded by: hsa:1582
constant: false
type: Species
is: SBO:0000252
boundary condition: true

metaR r1640
kinetic law: MODEL1310110014#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110014#
product: MODEL1310110014#
modifier: MODEL1310110014#
reversible: true
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_884f0682_4012_47f1_897a_90d312d10a41
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:1119
is: SBO:0000252
initial amount: NaN
is: P35790
constant: false
name: CHKA

metaR FAOXC164C165m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

metaR P4502C9
type: Reaction
reactant: MODEL1310110014#
is: SBO:0000176
fast: false
reversible: false
kinetic law: MODEL1310110014#
name: cytochrome P450 2C9
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1559.1) SUBSYSTEM: Cytochrome metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:2827463,PMID:3032244 NOTES:tolbutamide 4 methyl hydroxylation assumed to take place on outer membrane - xenobiotic metabolism NJ
product: MODEL1310110014#
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.14.13.48

metaR NACHEX21ly
reactant: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110014#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110014#
fast: false
modifier: MODEL1310110014#

metaR DMHPTCRNte
reactant: MODEL1310110014#
type: Reaction
name: 2,6 dimethylheptanoyl carnitine transport
is described by: ECO:0000000
reversible: true
product: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:unknown mechanism for transport -see PMID 9299016, identifies 2,6-dimethylheptanoyl carnitine in the urine! NJ
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110014#_d5f5939b_ba29_440a_ae1d_efd486dd4a3a
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:1962
name: EHHADH
initial amount: NaN
is: Q9NY65
has only substance units: false
boundary condition: true

metaR S2TASE2ly
is: SBO:0000176
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
product: MODEL1310110014#
fast: false
name: iduronate-2-sulfatase, lysosomal
is described by: ECO:0000000
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.13
reactant: MODEL1310110014#
modifier: MODEL1310110014#

metaM atp e
boundary condition: false
has only substance units: false
name: ATP(4-)
initial amount: NaN
type: Species
is: HMDB00538
is: C00002
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57299

http://identifiers.org/biomodels.db/MODEL1310110014#_9fd430d3_2204_442f_bcaa_bd6735849dd4
type: Species
has part: Q6IB04
has only substance units: false
is encoded by: hsa:84720
boundary condition: true
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
constant: false
name: PIGF:PIGO
is encoded by: hsa:5281

metaR UPPN
is version of: http://identifiers.org/ec-code/3.5.1.6
reversible: false
reactant: MODEL1310110014#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
type: Reaction
name: b-ureidopropionase
kinetic law: MODEL1310110014#
is: SBO:0000176
modifier: MODEL1310110014#
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_b9ddb7f3_ca8c_4d25_a67d_570702af5a65
initial concentration: NaN
is encoded by: hsa:8818
constant: false
boundary condition: true
name: DPM2
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species

metaR DALAt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
name: D-alanine transport via proton symport
modifier: MODEL1310110014#
fast: false
reactant: MODEL1310110014#
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110014#
is described by: ECO:0000304
product: MODEL1310110014#

metaM na1 c
is: C01330
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: Na CHARGE: 1
is: HMDB00588
is: CHEBI:4541
name: Sodium
constant: false

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaM stcoa c
is: SBO:0000247
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
name: Stearoyl-CoA (n-C18:0CoA)
has only substance units: false
is: CHEBI:57394
boundary condition: false
initial concentration: 1.0
is: HMDB01114
is: C00412
constant: false
initial amount: NaN
type: Species

metaR ADRNCPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110014#
is described by: ECO:0000000
reversible: false
fast: false
type: Reaction
name: carnitine transferase
is: SBO:0000176
modifier: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#

metaR r1641
kinetic law: MODEL1310110014#
product: MODEL1310110014#
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110014#
reversible: true

metaM dmnoncoa c
boundary condition: false
has only substance units: false
is: SBO:0000247
name: 4,8 dimethylnonanoyl-CoA
initial concentration: 1.0
constant: false
type: Species
is: HMDB11604
initial amount: NaN
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110014#_383e0cc7_bc44_435f_8737_b6f0a8596630
is: P30038
initial amount: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: ALDH4A1
is encoded by: hsa:8659

metaM no c
boundary condition: false
is: CHEBI:16480
has only substance units: false
is: HMDB03378
type: Species
name: Nitric oxide
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
initial concentration: 1.0
is: C00533

metaR CSPG Etly
is described by: ECO:0000000
name: chondroitin sulfate E transport, extracellular to lysosome
product: MODEL1310110014#
reactant: MODEL1310110014#
reversible: false
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110014#

metaM fad e
name: Flavin adenine dinucleotide oxidized
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false
has only substance units: false
is: C00016
is: SBO:0000247
initial amount: NaN
is: HMDB01248
type: Species
boundary condition: false
is: CHEBI:16238
initial concentration: 1.0

metaR HCO3 CLt
type: Reaction
kinetic law: MODEL1310110014#
is described by: ECO:0000269
reactant: MODEL1310110014#
fast: false
modifier: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM
reversible: true
name: bicarbonate transport (Cl-/HCO3- exchange)
product: MODEL1310110014#

metaR MAL Ltx
kinetic law: MODEL1310110014#
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000134
reversible: true
name: Transport reaction for malate
reactant: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.

metaR P4502C8
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1558.1) or (1558.2) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15579107 NOTES:paclitaxol 6 alpha hydroxylation assumed to take place on outer membrane - xenobiotic metabolism NJ
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000304
name: cytochrome P450 2C8
is version of: http://identifiers.org/ec-code/1.14.14.1
fast: false
reversible: false

metaR ALCD1
reversible: true
product: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (124.1) or (131.1) or (130.1) or (125.1 and 124.1) or (125.1 and 126.1) or (128.1) or (127.1) or (126.1 and 124.1) or (125.1) or (137872.1) or (284273.1) or (126.1) or (284273.2) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.1 Confidence Level: 4 AUTHORS: PMID:11128434,PMID:11762128,PMID:12592711,PMID:9806434 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.1.99.24
is: SBO:0000176
reactant: MODEL1310110014#
name: alcohol dehydrogenase (methanol)
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.1
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_86fec1e0_7988_4c96_8811_83b3772dd417
type: Species
name: NDUFA2
initial concentration: NaN
is: O43678
has only substance units: false
boundary condition: true
is encoded by: hsa:4695
is: SBO:0000252
constant: false
initial amount: NaN

metaM btn e
initial concentration: 1.0
notes: FORMULA: C10H15N2O3S CHARGE: -1
constant: false
is: SBO:0000247
is: CHEBI:3420
name: Biotin
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00030
has only substance units: false
is: C00120

metaR r0340
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.3.1.38
product: MODEL1310110014#
fast: false
modifier: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110014#
is: SBO:0000176
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110014#_a06b145a_7add_4d20_bef9_20534ea31dee
is: Q6IB80
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false
name: NDUFB3
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4709

metaR S6TASE17ly
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000176
type: Reaction
product: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false

metaR NDP10ex
modifier: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.6
kinetic law: MODEL1310110014#
is: SBO:0000176
fast: false
name: nucleoside-diphosphatase (IDP), extracellular
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_f9de3bd4_df15_4fa1_af5a_a38bf625014b
is: SBO:0000252
constant: false
name: SLC11A2
is encoded by: hsa:4891
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: B4DK84
boundary condition: true

metaR C18OHc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecanoylcarnitine
type: Reaction

metaR r1642
product: MODEL1310110014#
is: SBO:0000185
kinetic law: MODEL1310110014#
fast: false
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110014#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaR r2096
kinetic law: MODEL1310110014#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110014#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110014#
is described by: ECO:0000000

metaM bilglcur r
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
has only substance units: false
initial concentration: 1.0
is: CHEBI:57767
boundary condition: false
name: mono(glucosyluronic acid)bilirubin(2-)
is: SBO:0000247

metaM mthgxl e
is: HMDB01167
initial concentration: 1.0
is: CHEBI:17158
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
name: methylglyoxal
type: Species

metaM atp c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB00538
constant: false
type: Species
is: C00002
boundary condition: false
has only substance units: false
name: ATP(4-)
is: CHEBI:30616

metaR r1538
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
is version of: http://identifiers.org/ec-code/1.17.4.1
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000000
product: MODEL1310110014#
type: Reaction
fast: false
reversible: false
is: SBO:0000185

metaR THRt4
notes: GENE_ASSOCIATION: (11254.1) or (81539.1) or (54407.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958 NOTES:JLR
modifier: MODEL1310110014#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000269
reactant: MODEL1310110014#
type: Reaction
reversible: false
name: L-threonine via sodium symport

metaR HSD3A1r
fast: false
product: MODEL1310110014#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is version of: http://identifiers.org/ec-code/1.1.1.225
type: Reaction
reversible: true
reactant: MODEL1310110014#
is described by: ECO:0000269
kinetic law: MODEL1310110014#
is: SBO:0000176

metaR EX 3tetd7ecoacrn
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy tetradecenoyl-7-carnitine
type: Reaction

metaM eicostetcoa m
constant: false
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
boundary condition: false
type: Species
name: eicosatetranoyl coenzyme A
is: C16164
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM gdp e
is: HMDB01201
is: CHEBI:58189
initial amount: NaN
name: GDP(3-)
type: Species
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0

metaR FORMCOAtx
name: formyl coa transport
reversible: true
fast: false
kinetic law: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism see Verhoeven 11591435 and clayton 11356171 - added for peroxisomal oxidation of fatty acids NJ
product: MODEL1310110014#
is: SBO:0000185
type: Reaction

metaM 4hphac c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB00020
has only substance units: false
type: Species
constant: false
is: CHEBI:48999
name: 4-hydroxyphenylacetate
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
boundary condition: false

metaM fad c
type: Species
has only substance units: false
is: C00016
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB01248
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16238
name: Flavin adenine dinucleotide oxidized

metaM no e
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: C00533
type: Species
is: HMDB03378
is: CHEBI:16480
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
name: Nitric oxide
is: SBO:0000247

metaR RPEc
kinetic law: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
fast: false
is: SBO:0000176
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
name: ribulose 5-phosphate 3-epimerase
reactant: MODEL1310110014#

metaR r2097
is described by: ECO:0000000
reactant: MODEL1310110014#
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110014#
product: MODEL1310110014#
reversible: true
kinetic law: MODEL1310110014#

metaR r1643
reactant: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110014#
reversible: true
is: SBO:0000185
fast: false

metaR EX c51crn
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

metaM na1 e
initial amount: NaN
is: SBO:0000247
is: CHEBI:4541
is: HMDB00588
notes: FORMULA: Na CHARGE: 1
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
name: Sodium
is: C01330

http://identifiers.org/biomodels.db/MODEL1310110014#_70450ebe_afc3_49fb_b4e6_8bb471fda78d
has only substance units: false
initial amount: NaN
type: Species
name: CHST5
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:23563
constant: false

metaR RE3520E
reversible: true
is: SBO:0000176
product: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.9
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
is described by: ECO:0000000
fast: false
name: RE3520
modifier: MODEL1310110014#
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_8f7b8774_8772_428f_8b8d_de6b24d171cc
name: GCH1
has only substance units: false
is encoded by: hsa:2643
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
is: Q8IZH9
constant: false

metaR CRVNCtr
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110014#
product: MODEL1310110014#
fast: false
name: fatty acid transport via diffusion
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
is described by: ECO:0000000

metaM btn c
boundary condition: false
initial concentration: 1.0
is: CHEBI:3420
has only substance units: false
type: Species
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: HMDB00030
is: C00120
name: Biotin
initial amount: NaN
constant: false
is: SBO:0000247

metaR PI4PP
reactant: MODEL1310110014#
name: phosphatidylinositol-4-phosphate 4-phosphatase
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2425833 NOTES:NCD
is: SBO:0000176
reversible: false

metaR FACOAL245 2
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110014#
is: SBO:0000176
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
fast: false
product: MODEL1310110014#
is described by: ECO:0000269
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true

metaM tethex3coa x
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205478
is: C16168
name: tetracosahexaenoyl coenzyme A
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB06243
initial concentration: 1.0

metaR RE0344C
reactant: MODEL1310110014#
modifier: MODEL1310110014#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.2.2
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176
name: RE0344
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaR PSFLIPm
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: phosphatidylserine flippase
fast: false
is version of: http://identifiers.org/ec-code/3.6.3.1
product: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110014#_deba656f_23d3_432a_b497_a10860e2a830
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:9023
name: CH25H
is: O95992
type: Species
initial amount: NaN

metaR BPNT
name: 3',5'-bisphosphate nucleotidase
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
reversible: false
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.7
fast: false

metaM mthgxl c
initial concentration: 1.0
has only substance units: false
is: CHEBI:17158
is: HMDB01167
boundary condition: false
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
name: methylglyoxal
initial amount: NaN
is: SBO:0000247
constant: false
type: Species

metaR PROSTGF2t
name: prostaglandin uniport
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269
is: SBO:0000185
fast: false
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
reversible: true
product: MODEL1310110014#
modifier: MODEL1310110014#

metaR r2098
type: Reaction
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000185
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110014#

metaR r1644
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110014#
product: MODEL1310110014#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110014#
type: Reaction

metaR DOLPMT3 Ler
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.260
reversible: false
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000176
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
fast: false
reactant: MODEL1310110014#
type: Reaction
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_d975f6c7_d41a_43f7_b5c2_e7a883519cbb
constant: false
has only substance units: false
is encoded by: hsa:55577
initial concentration: NaN
type: Species
is: Q9UJ70
is: SBO:0000252
name: NAGK
initial amount: NaN
boundary condition: true

metaM dhor S c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:30864
type: Species
initial amount: NaN
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
boundary condition: false
name: (S)-dihydroorotate
constant: false
is: HMDB03349
has only substance units: false

metaR r1645
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110014#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110014#

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_e6b1df57_959a_4c8b_a2f7_6fd22bd8134a
constant: false
boundary condition: true
initial amount: NaN
name: GLS2
type: Species
is encoded by: hsa:27165
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR FACOAL245 1
reversible: true
product: MODEL1310110014#
is: SBO:0000176
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
reactant: MODEL1310110014#

metaM glcur c
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
name: D-glucuronate
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:15748
initial amount: NaN
is: HMDB00127
type: Species
initial concentration: 1.0

metaM gdp g
initial amount: NaN
is: CHEBI:58189
type: Species
name: GDP(3-)
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB01201
initial concentration: 1.0
has only substance units: false

metaM thbpt4acam n
initial amount: NaN
name: 4a-hydroxytetrahydrobiopterin
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:15374
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: HMDB02281

metaR r2099
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
kinetic law: MODEL1310110014#
product: MODEL1310110014#
modifier: MODEL1310110014#
reversible: true
fast: false
reactant: MODEL1310110014#
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM ala L e
is: CHEBI:16977
is: HMDB00161
type: Species
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
has only substance units: false
name: L-alanine
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaM 4hphac e
boundary condition: false
is: HMDB00020
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: CHEBI:48999
name: 4-hydroxyphenylacetate
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642

http://identifiers.org/biomodels.db/MODEL1310110014#_e9c0584c_bf71_4643_b35b_135c35214809
has only substance units: false
boundary condition: true
constant: false
is: Q6IBB5
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: NDUFA1
is encoded by: hsa:4694

metaR SIAASE4ly
name: sialidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
is described by: ECO:0000000
product: MODEL1310110014#
is: SBO:0000176
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5

metaM ksii core2 pre7 g
notes: FORMULA: C67H108N5O51SX CHARGE: -2
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: C00130
is: HMDB00175
initial amount: NaN
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 7
boundary condition: false
constant: false

metaM hmgcoa x
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: CHEBI:15467
is: HMDB01375
constant: false
name: Hydroxymethylglutaryl-CoA

metaR r0595
is: SBO:0000176
kinetic law: MODEL1310110014#
is described by: ECO:0000000
name: 3-Mercaptopyruvate:cyanide sulfurtransferase Cysteine metabolism EC:2.8.1.2
type: Reaction
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 2.8.1.2 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:851908 NOTES:
fast: false
reversible: false
product: MODEL1310110014#

metaM HC01610 e
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:28607
name: CoproporphyrinogenI

metaR CRNtim
name: L-carnitine transport out of mitochondria via diffusion
fast: false
product: MODEL1310110014#
reversible: false
kinetic law: MODEL1310110014#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction

metaM nicrns c
is: HMDB06809
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C11H13NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01628 EHMN_ABBREVIATION: C05841
name: Nicotinate D-ribonucleoside
type: Species
constant: false
is: CHEBI:58527
has only substance units: false

metaM man6p c
constant: false
has only substance units: false
type: Species
boundary condition: false
is: HMDB01078
initial concentration: 1.0
is: CHEBI:17369
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
name: D-Mannose 6-phosphate
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_be97f567_a7ae_4c14_a451_464963c89407
is encoded by: hsa:206
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
name: _206_1_c
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_bcdb96a4_988e_45a3_a426_d9d6e9fc00a4
constant: false
initial amount: NaN
has only substance units: false
is: B2R6S5
initial concentration: NaN
name: CMPK1
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:51727

metaR RE1796R
modifier: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110014#
product: MODEL1310110014#
reversible: true
name: RE1796
is version of: http://identifiers.org/ec-code/1.1.1.145
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
type: Reaction
kinetic law: MODEL1310110014#
fast: false

metaR KSII CORE2tly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
fast: false
kinetic law: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110014#
name: keratan sulfate II (core 2) transport, extracellular to lysosome

metaR FAOXC16OHC16r
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

metaR 3SALATAim
is: SBO:0000176
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial
reactant: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
kinetic law: MODEL1310110014#

metaR CDSm
reactant: MODEL1310110014#
is described by: ECO:0000000
product: MODEL1310110014#
name: phosphatidate cytidylyltransferase
type: Reaction
is: SBO:0000176
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.7.41
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
fast: false
kinetic law: MODEL1310110014#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110014#_a40a9765_b60e_47d5_85bb_6b0fba86fa0b
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4713
initial concentration: NaN
name: NDUFB7
constant: false
boundary condition: true
has only substance units: false
is: P17568
type: Species

metaR r2389
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110014#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaM oh1 c
boundary condition: false
is: C01328
type: Species
initial concentration: 1.0
name: hydroxide ion
constant: false
has only substance units: false
notes: FORMULA: HO CHARGE: -1
initial amount: NaN
is: HMDB01039
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_257eb9a4_b840_4b5b_8f51_8b9c1daf3bc6
boundary condition: true
is encoded by: hsa:65985
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: Q86V21
is: SBO:0000252
name: AACS
initial amount: NaN

metaM accoa n
boundary condition: false
is: SBO:0000247
name: acetyl-CoA(4-)
is: CHEBI:57288
type: Species
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: HMDB01206

metaM 4mzym int1 r
initial amount: NaN
name: 4-Methylzymosterol intermediate 1
is: HMDB06927
boundary condition: false
type: Species
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_f3417ae0_45b3_4709_8166_889595ba7410
is encoded by: hsa:29880
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: ALG5
constant: false
has only substance units: false
is: Q9Y673
boundary condition: true
type: Species

metaM Nacasp m
boundary condition: false
constant: false
type: Species
name: N-acetyl-L-aspartate(2-)
is: CHEBI:16953
initial amount: NaN
is: HMDB00812
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
is: SBO:0000247

metaR r0596
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
is: SBO:0000176
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
fast: false

metaR NDPK3m
is: SBO:0000176
reversible: true
is described by: ECO:0000254
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
reactant: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial

metaR ACCOAC
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaM pail3p hs c
constant: false
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58088
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
initial amount: NaN

metaM hs deg23 l
notes: FORMULA: C31H49NO29S CHARGE: -2
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:21338
is: HMDB02704
initial amount: NaN
constant: false
is: SBO:0000247
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose

metaR RE1519M
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.13
type: Reaction
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
name: RE1519
modifier: MODEL1310110014#
is described by: ECO:0000000
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#

metaM accoa m
has only substance units: false
initial amount: NaN
is: CHEBI:57288
is: HMDB01206
is: C00024
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
name: Acetyl-CoA
type: Species
boundary condition: false
constant: false

metaR EX 4mtolbutamide LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4 hydroxy tolbutamide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_d40f455b_f4dc_4e11_8477_65961e018287
is: SBO:0000252
is: A8K596
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:1757
name: SARDH
type: Species

metaM oh1 e
is: HMDB01039
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: HO CHARGE: -1
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
name: hydroxide ion
is: C01328

metaR RE1342C
reversible: true
name: RE1342
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000
fast: false
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
type: Reaction

metaR 3HAO
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.6
is: SBO:0000176
name: 3-hydroxyanthranilate 3,4-dioxygenase
modifier: MODEL1310110014#
reversible: false
is described by: ECO:0000269
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (23498.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.13.11.6 Confidence Level: 4 AUTHORS: PMID:7514594 NOTES:NCD
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#

metaR C100CPT1
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decanoylcarnitine
type: Reaction

metaR BAAT3x
is described by: ECO:0000304
product: MODEL1310110014#
modifier: MODEL1310110014#
reactant: MODEL1310110014#
name: bile acid Coenzyme A: amino acid N-acyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:third version analog added as per KEGG NJ
fast: false
reversible: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_251cee6f_cee3_42bd_a54f_6e87af4aeeaa
name: PFKM:PFKP
boundary condition: true
is encoded by: hsa:5213
initial concentration: NaN
is: SBO:0000297
type: Species
constant: false
initial amount: NaN
has part: P08237
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_49055cfa_e60f_4c8a_aed3_14d173d150f5
boundary condition: true
name: _R39999_1_c
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:R39999
type: Species
initial amount: NaN

metaR r0068
type: Reaction
reversible: false
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (134526.1) SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.1
is described by: ECO:0000000
reactant: MODEL1310110014#
name: Acetyl adenylate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
modifier: MODEL1310110014#
fast: false
product: MODEL1310110014#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110014#_ef8ef441_3cbf_4191_9a28_7de563c1bc76
is encoded by: hsa:728441
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: GGT2
constant: false

metaM prostgi2 c
has only substance units: false
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: HMDB01335
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: CHEBI:57403
boundary condition: false
name: prostaglandin I2(1-)

http://identifiers.org/biomodels.db/MODEL1310110014#_1fabe564_7826_4402_84aa_7b7a8a7f274a
has only substance units: false
initial amount: NaN
is encoded by: hsa:10380
constant: false
is: SBO:0000252
is: O95861
name: BPNT1
boundary condition: true
type: Species
initial concentration: NaN

metaR r2387
is described by: ECO:0000000
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
reactant: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110014#
is: SBO:0000185
type: Reaction

metaM cdpdag hs m
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
is: CHEBI:58332
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
name: CDP-diacylglycerol(2-)
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_87e1f439_51aa_480b_a5c5_7c22044d64c3
initial concentration: NaN
is: SBO:0000297
has only substance units: false
constant: false
is encoded by: hsa:56301
type: Species
is encoded by: hsa:6520
boundary condition: true
has part: P08195
initial amount: NaN
name: SLC7A10:SLC3A2
has part: Q9NS82

metaR S6T18g
reactant: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.2.17
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.8.2.21
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
is: SBO:0000176
modifier: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD

metaR DCMPDA
is described by: ECO:0000254
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.5.4.12
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
modifier: MODEL1310110014#
fast: false
is: SBO:0000176
reversible: true
type: Reaction
name: dCMP deaminase

http://identifiers.org/biomodels.db/MODEL1310110014#_33abf937_fe1a_4ef8_9d4b_49d3b0eb41fa
is: P07864
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
name: LDHC
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:3948

metaR PRPNCOAHYDm
type: Reaction
reactant: MODEL1310110014#
is: SBO:0000176
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.18
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
is described by: ECO:0000134
reversible: false
name: Propenoyl-CoA hydrolase (m)
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110014#_4f018d39_23d6_441b_8ead_6ba969ef9c83
constant: false
initial amount: NaN
name: ASS1
boundary condition: true
is encoded by: hsa:445
type: Species
is: Q5T6L4
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM m5masnB2 g
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C52H87N2O40X CHARGE: 0
is: CHEBI:58469
type: Species
has only substance units: false
boundary condition: false
is: HMDB01313
constant: false

metaR r0594
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110014#
reversible: true
type: Reaction
product: MODEL1310110014#
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
kinetic law: MODEL1310110014#

metaR RE2974N
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
kinetic law: MODEL1310110014#
is: SBO:0000176
product: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true
type: Reaction
name: RE2974

metaM c81coa c
is: SBO:0000247
name: octenoylcoa
constant: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
boundary condition: false
is: C05276
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB03949

metaR FRDPtc
reactant: MODEL1310110014#
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110014#
reversible: true
product: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaR EX 3octdece1crn
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-octadecenoyl carnitine
type: Reaction

metaR FAOXC161C161OHm
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of 3-hydroxyhexadecenoylcoA
type: Reaction

metaR G14T16g
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
type: Reaction
is: SBO:0000176
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110014#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
product: MODEL1310110014#

metaR r2388
kinetic law: MODEL1310110014#
is: SBO:0000185
product: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reactant: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
reversible: false

metaR BTNPLm
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
type: Reaction
fast: false
kinetic law: MODEL1310110014#
is: SBO:0000176
product: MODEL1310110014#
modifier: MODEL1310110014#
reactant: MODEL1310110014#
reversible: false
is version of: http://identifiers.org/ec-code/6.3.4.10

metaM ibcoa m
is: HMDB01243
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
has only substance units: false
is: CHEBI:57338
type: Species
boundary condition: false
constant: false
name: isobutyryl-CoA(4-)
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM tag1p D c
has only substance units: false
name: D-Tagatose 1-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1/C6H13O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h3,5-8,10-11H,1-2H2,(H2,12,13,14)/t3-,5+,6-/m1/s1
is: HMDB06328
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaM ksi deg2 l
boundary condition: false
is: CHEBI:30825
is: HMDB00573
constant: false
is: SBO:0000247
notes: FORMULA: C241H384N17O210S12 CHARGE: -13
has only substance units: false
type: Species
initial amount: NaN
name: keratan sulfate I, degradation product 2
initial concentration: 1.0

metaM dopasf e
name: dopamine 3-O-sulfate
is: SBO:0000247
type: Species
is: CHEBI:37946
constant: false
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
is: HMDB06275
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_6e394a21_d188_4fd2_994f_1eaf70624df8
boundary condition: true
constant: false
is encoded by: hsa:7378
is: SBO:0000252
type: Species
initial concentration: NaN
name: UPP1
has only substance units: false
initial amount: NaN

metaR r0591
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110014#
type: Reaction
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#

metaR HIStN1
name: Histidine transport (Na, H coupled)
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000269
product: MODEL1310110014#
type: Reaction
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reactant: MODEL1310110014#

metaR FAOXC204
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
fast: false
reversible: false
type: Reaction
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
modifier: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000269
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110014#_fbf54106_4eec_4f7b_aad5_fdeb096155cc
is encoded by: hsa:6240
is: P23921
boundary condition: true
name: RRM1
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: NaN

metaM pheacgln c
is: SBO:0000247
is: HMDB06344
constant: false
initial amount: NaN
has only substance units: false
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
boundary condition: false
is: CHEBI:58310
initial concentration: 1.0
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
type: Species

metaR r2385
product: MODEL1310110014#
is: SBO:0000185
fast: false
modifier: MODEL1310110014#
reactant: MODEL1310110014#
reversible: false
kinetic law: MODEL1310110014#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR RBFK
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.1.26
is described by: ECO:0000269
modifier: MODEL1310110014#
fast: false
reactant: MODEL1310110014#
is: SBO:0000176
reversible: false
type: Reaction
name: riboflavin kinase
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR CBPSam
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: false
product: MODEL1310110014#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.16
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1373.1) or (1373.2) SUBSYSTEM: Glutamate metabolism EC Number: 6.3.4.16 Confidence Level: 4 AUTHORS: PMID:10347186,PMID:12853138 NOTES:MM
name: carbamoyl-phosphate synthase (ammonia) (mitochondria
reactant: MODEL1310110014#

metaR SCPx
reactant: MODEL1310110014#
product: MODEL1310110014#
fast: false
name: peroxisomal thiolase 2
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.176
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ

metaM o2s n
initial amount: NaN
name: superoxide
boundary condition: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB02168
is: CHEBI:18421
has only substance units: false
constant: false

metaM prostgi2 e
type: Species
boundary condition: false
name: prostaglandin I2(1-)
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57403
is: HMDB01335
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_0c0c406a_1c2b_4b01_87f1_74836ddb6e47
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:760
name: CA2
boundary condition: true
is: P00918

metaR GALASE4ly
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110014#
type: Reaction
is: SBO:0000176

metaM fad m
is: SBO:0000247
name: Flavin adenine dinucleotide oxidized
has only substance units: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial amount: NaN
is: CHEBI:16238
is: HMDB01248
type: Species
boundary condition: false
is: C00016
constant: false
initial concentration: 1.0

metaR r1435
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
reversible: false
name: Transport reaction
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#

metaM nrpphr e
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00216
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:33569
name: Norepinephrine

metaM sbcoa c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
boundary condition: false
name: suberylcoa
constant: false
is: HMDB00791
is: SBO:0000247
is: C02838
has only substance units: false
type: Species

metaM ksii core2 deg5 l
initial concentration: 1.0
type: Species
notes: FORMULA: C50H82N4O38SX CHARGE: -1
is: SBO:0000247
has only substance units: false
is: CHEBI:12936
is: HMDB00143
boundary condition: false
constant: false
name: keratan sulfate II (core 2-linked), degradation product 5
initial amount: NaN

metaR SUCOAS1m
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
is: SBO:0000176
kinetic law: MODEL1310110014#
product: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.4
name: Succinate--CoA ligase (GDP-forming)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_91b06a7c_9482_4acc_a03a_25dddd677e27
has only substance units: false
is: Q16718
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:4698
name: NDUFA5
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_7ba746bb_7ff5_4cc9_9490_368eb562a5cd
initial concentration: NaN
is: Q86YT5
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:284111
name: SLC13A5

metaM o2s m
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
type: Species
name: Superoxide anion
boundary condition: false
is: SBO:0000247
has only substance units: false
is: C00704
initial concentration: 1.0
is: CHEBI:18421
constant: false
initial amount: NaN
is: HMDB02168

metaR r2386
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110014#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110014#
reversible: false

metaR ACGAM6PSi
is version of: http://identifiers.org/ec-code/2.3.1.4
reactant: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: (64841.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.3.1.4 Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
is described by: ECO:0000304
name: N-acetylglucosamine-6-phosphate synthase
product: MODEL1310110014#
fast: false

metaM dopasf c
name: dopamine 3-O-sulfate
is: SBO:0000247
boundary condition: false
type: Species
constant: false
is: HMDB06275
has only substance units: false
is: CHEBI:37946
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690

metaR CYTK1m
is: SBO:0000176
name: cytidylate kinase (CMP),mitochondrial
reactant: MODEL1310110014#
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
type: Reaction

metaR NADPtxu
is: SBO:0000185
fast: false
reversible: false
product: MODEL1310110014#
name: NADP transporter, peroxisome
type: Reaction
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ potential for free H NJ

metaR r1434
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
reversible: false
name: Transport reaction
kinetic law: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110014#
product: MODEL1310110014#
fast: false

metaR RE1796M
reversible: true
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
modifier: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.1.1.145
fast: false
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: RE1796
type: Reaction

metaR SIAT4Bg
is described by: ECO:0000269
fast: false
is: SBO:0000176
product: MODEL1310110014#
reactant: MODEL1310110014#
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.99.4
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
reversible: false

metaR CYTK1n
modifier: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
fast: false
product: MODEL1310110014#
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110014#
name: cytidylate kinase (CMP),nuclear

metaR FAOXC163GC142m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_0309fb56_cf1f_4f61_8508_01503c07ac10
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: E9PB82
initial concentration: NaN
type: Species
name: HSD17B4
boundary condition: true
constant: false
is encoded by: hsa:3295

metaR EX sl L LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-sulfolactate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_1076470d_e5a4_4709_9f5f_9e60a8b77fdd
is: SBO:0000252
initial concentration: NaN
name: DGKB
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:1607
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_fd53edf0_f13d_4fd1_a316_d7dcebf55714
boundary condition: true
is: P24310
constant: false
is encoded by: hsa:1346
name: COX7A1
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaM dlnlcgcrn c
is: SBO:0000247
is: HMDB01311
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: dihomo-gamma-linolenyl carnitine
constant: false
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
has only substance units: false
is: CHEBI:16004

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_caf78462_8ba9_4abc_ad09_c38e308ede7f
has only substance units: false
is: Q8TD30
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:84706
name: GPT2
constant: false
is: SBO:0000252

metaR r1433
reactant: MODEL1310110014#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110014#
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_871d727e_2d4d_4cfe_be49_c9971342dbc3
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:AI684467
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: _AI684467_1_m
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_465cecf2_e240_4383_9578_68c7f73ab1de
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:8733
name: GPAA1
has only substance units: false
is: O43292

metaR r0590
reversible: false
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
modifier: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:

metaR MEVK1c
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.1.36
fast: false
reversible: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110014#
name: mevalonate kinase (atp) cytosol
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134

metaM hs deg5 l
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
name: heparan sulfate, degradation product 5
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
type: Species
is: CHEBI:17895
has only substance units: false
is: HMDB00158

metaM nrpphr c
type: Species
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00216
name: Norepinephrine
initial concentration: 1.0
is: CHEBI:33569
is: SBO:0000247
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547

http://identifiers.org/biomodels.db/MODEL1310110014#_810a4660_fe41_47a3_b772_353538d466ee
is: P13686
constant: false
has only substance units: false
name: ACP5
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:54
is: SBO:0000252
boundary condition: true
type: Species

metaM 5htrp c
name: 5-hydroxy-L-tryptophan
is: HMDB00472
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
boundary condition: false
is: CHEBI:17780

http://identifiers.org/biomodels.db/MODEL1310110014#_fccecd8e_02f8_4f1f_9c3b_3ef74c9afaea
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
is: Q9H0P0
initial concentration: NaN
is encoded by: hsa:51251
name: NT5C3
type: Species

metaR NACHEX17ly
is: SBO:0000176
product: MODEL1310110014#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110014#_9f160252_3201_4d01_9a9a_79e1a910399f
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: SI
constant: false
initial amount: NaN
is encoded by: hsa:6476
is: P14410
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_950c55ca_9c94_4915_b5c1_69cdf0315fd0
is encoded by: hsa:1329
type: Species
name: COX5B
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: Q53YB7

metaR r2384
reactant: MODEL1310110014#
fast: false
reversible: false
modifier: MODEL1310110014#
is: SBO:0000185
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM aacoa m
constant: false
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB01484
initial amount: NaN
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: SBO:0000247
is: CHEBI:57286
name: acetoacetyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110014#_95101b69_a734_4e54_80fc_19ee1f2b0b02
is: Q86VN9
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: ABCC3
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8714

metaR FAOXC161C141m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:1-->C14:1)m
type: Reaction

metaM ddece1crn c
has only substance units: false
initial amount: NaN
name: dodecenoyl carnitine
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB03712
notes: FORMULA: C19H35NO4 CHARGE: 0
constant: false
initial concentration: 1.0

metaM 6pgl r
initial concentration: 1.0
constant: false
type: Species
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB01127
is: CHEBI:57955
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
initial amount: NaN

metaR CPPPGO
is described by: ECO:0000304
type: Reaction
name: coproporphyrinogen oxidase (O2 required)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.3
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (1371.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.3 Confidence Level: 2 AUTHORS: PMID:8407975 NOTES:r0608, JLR
modifier: MODEL1310110014#
fast: false
reversible: false

metaR APNNOXte
name: xenobiotic transport
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, xenobiotic transport (original and metabolized) NJ
is described by: ECO:0000000
product: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: true
is: SBO:0000185
fast: false
type: Reaction

metaM dhbpt c
constant: false
initial amount: NaN
type: Species
name: 6,7-dihydrobiopterin
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
is: CHEBI:20680
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00038

metaR FTCD
name: formimidoyltransferase cyclodeaminase
product: MODEL1310110014#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.1.2.5
type: Reaction
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
fast: false
reversible: false
reactant: MODEL1310110014#
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000176

metaM apnnox e
has only substance units: false
initial amount: NaN
name: alpha-pinene oxide
type: Species
boundary condition: false
constant: false
is: CHEBI:29060
initial concentration: 1.0
notes: FORMULA: C10H16O CHARGE: 0 INCHI: InChI=1S/C10H16O/c1-9(2)6-4-7(9)10(3)8(5-6)11-10/h6-8H,4-5H2,1-3H3
is: SBO:0000247
is: HMDB03667

metaR NAGA2ly
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
product: MODEL1310110014#
is: SBO:0000176
modifier: MODEL1310110014#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.49
is described by: ECO:0000000
name: N-acetylgalactosaminidase, alpha-

metaR RE1254C
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
name: RE1254
is: SBO:0000176
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reversible: true
fast: false
type: Reaction

metaR S6T5g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
type: Reaction
kinetic law: MODEL1310110014#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110014#
product: MODEL1310110014#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
modifier: MODEL1310110014#

metaM andrstrn r
initial concentration: 1.0
is: CHEBI:16032
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
is: HMDB00031
is: SBO:0000247
constant: false
name: androsterone
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false

metaM hs deg9 l
has only substance units: false
type: Species
constant: false
boundary condition: false
name: heparan sulfate, degradation product 9
initial concentration: 1.0
is: HMDB00187
initial amount: NaN
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
is: SBO:0000247
is: CHEBI:17115

metaM ptth c
initial amount: NaN
initial concentration: 1.0
is: HMDB03426
boundary condition: false
type: Species
is: CHEBI:16753
constant: false
name: pantetheine
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
has only substance units: false
is: SBO:0000247

metaM cs e l
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB02183
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
is: CHEBI:36005
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
type: Species

metaM pap g
is: HMDB00061
initial amount: NaN
name: adenosine 3',5'-bismonophosphate(4-)
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:58343
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
constant: false

metaM fad r
constant: false
initial amount: NaN
is: HMDB01248
name: Flavin adenine dinucleotide oxidized
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:16238
type: Species

metaM 3octpencoa m
initial amount: NaN
name: 3,6,9,12,15-octadecapentenoylcoa
is: SBO:0000247
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/5280355

http://identifiers.org/biomodels.db/MODEL1310110014#_d422a1b0_3c47_4b0e_8c33_e3af7c2573a9
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI971036
name: _AI971036_1_x
is: SBO:0000252
constant: false

metaR FAOXC7C5m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C7-->C5)m
type: Reaction

metaM HC01415 m
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:27537
boundary condition: false
name: (2E)-Octenoyl-CoA
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_2340784d_8244_448c_a74f_611558dde6ec
type: Species
is: SBO:0000252
is: O95528
boundary condition: true
initial concentration: NaN
constant: false
name: SLC2A10
is encoded by: hsa:81031
has only substance units: false
initial amount: NaN

metaM ksi pre3 g
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00175
constant: false
name: keratan sulfate I biosynthesis, precursor 3
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C93H152N6O67X CHARGE: -1
is: CHEBI:58053
is: C00130
boundary condition: false

metaM c6crn x
constant: false
is: HMDB00705
type: Species
boundary condition: false
initial concentration: 1.0
name: hexanoyl carnitine
notes: FORMULA: C13H25NO4 CHARGE: 0
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaM ppa e
boundary condition: false
initial amount: NaN
is: HMDB00237
initial concentration: 1.0
is: CHEBI:17272
type: Species
name: propionate
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_a26dbee3_bb27_4686_a0c1_a5b648a972ed
is encoded by: hsa:1468
name: SLC25A10
boundary condition: true
is: Q9UBX3
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

metaM doco13ac e
constant: false
name: docosenoic acid (C22:1)
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C22H41O2 CHARGE: -1
is: HMDB02068
is: SBO:0000247
initial amount: NaN

metaM ptth e
type: Species
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:16753
has only substance units: false
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1
is: HMDB03426
name: pantetheine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_a6372b9a_de2b_44f2_9ef8_de819258790c
name: HIBCH
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:26275
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q6NVY1

metaR CATm
kinetic law: MODEL1310110014#
is described by: ECO:0000269
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (847.1) SUBSYSTEM: ROS detoxification EC Number: 1.11.1.6 Confidence Level: 4 AUTHORS: PMID:1657986,PMID:3755525 NOTES:TV
product: MODEL1310110014#
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.11.1.6
fast: false
reactant: MODEL1310110014#
name: catalase
is: SBO:0000176

metaR r0488
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000176
fast: false
reversible: true
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
type: Reaction

metaM ksii core2 deg3 l
boundary condition: false
type: Species
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
initial amount: NaN
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 3
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:12936
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110014#_eb8d71f1_84c4_4ee3_aa90_3c831da2ed7f
boundary condition: true
is encoded by: hsa:5959
has only substance units: false
is: SBO:0000252
is: Q92781
initial amount: NaN
name: RDH5
constant: false
type: Species
initial concentration: NaN

metaM itp c
is: HMDB00189
type: Species
constant: false
is: CHEBI:57614
is: SBO:0000247
has only substance units: false
name: ITP(3-)
boundary condition: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_700b3184_54f4_4a3b_b15f_f265cb14f2c2
name: GAMT
constant: false
is encoded by: hsa:2593
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR G14T7g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110014#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110014#
fast: false

metaR NADPHtru
reactant: MODEL1310110014#
name: NADPH transporter, endoplasmic reticulum
kinetic law: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
reversible: false
type: Reaction
product: MODEL1310110014#
is: SBO:0000185

metaR C14STRr
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
product: MODEL1310110014#
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000176
fast: false
reversible: false
name: C-14 sterol reductase
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.3.1.70

metaM ppa c
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00237
name: propionate
has only substance units: false
type: Species
is: CHEBI:17272
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163

http://identifiers.org/biomodels.db/MODEL1310110014#_cee89672_6adf_4e2f_a1a5_40de4e97a1b1
is encoded by: hsa:2542
constant: false
name: SLC37A4
is: A8K0S7
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true

metaM xu1p D c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: HMDB06534
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h3,5-7,9H,1-2H2,(H2,10,11,12)/t3-,5-/m1/s1
name: D-Xylulose 1-phosphate
constant: false

metaR C4DCCACT
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinyl carnitine into cytosol
type: Reaction

metaM uri c
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
boundary condition: false
is: CHEBI:16704
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
name: Uridine
initial amount: NaN
is: HMDB00296
is: C00299
is: SBO:0000247

metaR S26Tg
name: beta-galactoside alpha-2,6-sialyltransferase
modifier: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.99.1
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (6480.1) or (6480.3) or (6480.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.99.1 Confidence Level: 0 AUTHORS: PMID:8027041 NOTES:NCD
product: MODEL1310110014#
fast: false
reversible: false
kinetic law: MODEL1310110014#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_9d90afb8_41b7_494a_9b1f_2884a7f59084
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
name: _AI620219_1_m
is encoded by: hsa:AI620219
boundary condition: true
initial concentration: NaN
type: Species

metaR DM gpi sig er
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_2c60a46f_714d_412d_b7c3_7114363adab3
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:10797
name: MTHFD2
has only substance units: false
is: P13995
is: SBO:0000252
initial amount: NaN
type: Species

metaR SUCCACT
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of succinate
type: Reaction

metaR C10CRNe
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decanoyl carnitine into extra cellular space
type: Reaction

metaR GLCAASE8ly
reversible: false
name: beta-glucuronidase, lysosomal
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
fast: false
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.31
modifier: MODEL1310110014#
product: MODEL1310110014#

metaR FAOXC5C5OHm
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C5OH)m
type: Reaction

metaR 5ADTSTSTERONEte
reversible: true
is: SBO:0000185
name: 5 alpha dihydrotesterone transport
fast: false
is described by: ECO:0000000
reactant: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR FAOXC226C225x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_ad2265e1_3f85_406a_a857_cfe9e9a7fdc3
has only substance units: false
is: SBO:0000252
constant: false
name: ACAD10
is: G3XAJ0
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:80724
initial amount: NaN

metaM itp e
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
constant: false
is: HMDB00189
initial concentration: 1.0
is: CHEBI:57614
is: SBO:0000247
name: ITP(3-)
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species

metaR r0139
is: SBO:0000176
modifier: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
fast: false
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.2.2
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is described by: ECO:0000000

metaM pap c
is: SBO:0000247
name: adenosine 3',5'-bismonophosphate(4-)
type: Species
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
initial concentration: 1.0
is: CHEBI:58343
initial amount: NaN
is: HMDB00061
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_681243fa_df58_4bbd_b0f1_7e3eaa98e4a2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:113
constant: false
initial concentration: NaN
initial amount: NaN
name: ADCY7
is: P51828
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_f63b6c39_4b9d_407a_a91c_5f0961819db4
is encoded by: hsa:28976
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: Q9H845
is: SBO:0000252
name: ACAD9
has only substance units: false
type: Species

metaR DHPM1
name: dihydropyrimidinase (5,6-dihydrouracil)
reactant: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.5.2.2
modifier: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
kinetic law: MODEL1310110014#
reversible: false

metaM aacoa c
name: Acetoacetyl-CoA
is: CHEBI:57286
boundary condition: false
is: HMDB01484
has only substance units: false
initial concentration: 1.0
constant: false
is: C00332
is: SBO:0000247
type: Species
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
initial amount: NaN

metaR EX creat LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Creatine exchange
type: Reaction

metaR C4tcx
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine from peroxisomes
type: Reaction

metaR FAOXC142C122x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_0edab27b_4ab6_4e20_9963_f72a59ab063a
has only substance units: false
is: SBO:0000252
name: DPM1
is encoded by: hsa:8813
initial concentration: NaN
constant: false
boundary condition: true
type: Species
initial amount: NaN
is: O60762

metaR HEXDICOAACBP
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioyl coa
type: Reaction

metaM o2s e
is: HMDB02168
is: SBO:0000247
constant: false
boundary condition: false
name: superoxide
type: Species
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial concentration: 1.0
has only substance units: false
is: CHEBI:18421
initial amount: NaN

metaM Nacasp c
initial concentration: 1.0
is: HMDB00812
is: SBO:0000247
type: Species
constant: false
has only substance units: false
boundary condition: false
name: N-acetyl-L-aspartate(2-)
initial amount: NaN
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
is: CHEBI:16953

metaM uri e
is: HMDB00296
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: CHEBI:16704
name: Uridine
initial amount: NaN
initial concentration: 1.0
constant: false
is: C00299
type: Species
boundary condition: false

metaR ASPDTDe
kinetic law: MODEL1310110014#
is: SBO:0000185
reversible: true
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
name: D-aspartate transport, extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: D-aspartate may exit by diffusion or require specific transporters. NOTES:D-aspartate may exit by diffusion or require specific transporters.
fast: false
type: Reaction

metaM ddece1crn e
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: dodecenoyl carnitine
is: SBO:0000247
constant: false
is: HMDB02250
boundary condition: false
notes: FORMULA: C19H35NO4 CHARGE: 0
type: Species

metaM accoa x
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: C00024
is: HMDB01206
constant: false
is: SBO:0000247
is: CHEBI:57288
name: Acetyl-CoA
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species

metaM 5HPET r
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
name: 5(S)-HPETE(1-)
is: HMDB01193
is: CHEBI:57450
has only substance units: false

metaM apnnox c
is: CHEBI:29060
type: Species
is: HMDB03667
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H16O CHARGE: 0 INCHI: InChI=1S/C10H16O/c1-9(2)6-4-7(9)10(3)8(5-6)11-10/h6-8H,4-5H2,1-3H3
constant: false
name: alpha-pinene oxide

http://identifiers.org/biomodels.db/MODEL1310110014#_1833090b_6c4c_433d_9f5f_35bc581c1e51
constant: false
is encoded by: hsa:AA502753
type: Species
has only substance units: false
initial amount: NaN
name: _AA502753_1_m
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_f55845ea_a882_42f1_8adc_19f9f5f267de
is: SBO:0000252
name: ARSA
has only substance units: false
is encoded by: hsa:410
type: Species
initial concentration: NaN
initial amount: NaN
is: P15289
constant: false
boundary condition: true

metaR LEUKTRE4t
is: SBO:0000185
reactant: MODEL1310110014#
name: leukotriene E4 transport
kinetic law: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
reversible: true

metaM 2mb2coa c
constant: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1
name: 2-methylcrotonoyl-CoA(4-)
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB02054
boundary condition: false
initial concentration: 1.0

metaR FAOXC240200x
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
reactant: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:0 -> c20:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
reversible: false
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000

metaR BALAtmr
is: SBO:0000185
fast: false
reversible: true
name: Beta-alanine reversible mitochondrial transport (diffusion)
kinetic law: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
reactant: MODEL1310110014#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110014#_3080db54_5e33_4db5_81e5_2e070320f6fc
has only substance units: false
constant: false
name: BTD
is encoded by: hsa:686
is: P43251
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_0a3cd41e_9a12_4676_b9cc_4ad94e851ef3
constant: false
name: AMACR
is: Q9UHK6
is encoded by: hsa:23600
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM fad x
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16238
constant: false
name: Flavin adenine dinucleotide oxidized
type: Species
boundary condition: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial amount: NaN
is: HMDB01248

metaR sink octdececoa LPAREN c RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: OCTDECECOASINK
type: Reaction

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaR ALATA L
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.6.1.2
name: L-alanine transaminase
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2875.1) or (84706.1) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.1.2 Confidence Level: 4 AUTHORS: PMID:11863375 NOTES:
is described by: ECO:0000269
is: SBO:0000176
reversible: true
product: MODEL1310110014#
reactant: MODEL1310110014#

metaR FAOXC121C10x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_cf5de529_178f_47e1_9fb8_354043b8abbd
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: PPT1
is: SBO:0000252
is encoded by: hsa:5538
is: Q6FGQ4
boundary condition: true

metaM ksi pre7 g
has only substance units: false
constant: false
is: CHEBI:58053
is: SBO:0000247
boundary condition: false
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 7
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C115H187N8O85SX CHARGE: -2
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110014#_9770e9b8_f19f_4e0a_98f9_9306e26921af
type: Species
name: AQP8
boundary condition: true
constant: false
initial concentration: NaN
is: O94778
is: SBO:0000252
is encoded by: hsa:343
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_37c23ba0_de13_45cd_8d37_a11ecb78326d
has only substance units: false
is encoded by: hsa:11164
constant: false
is: Q9UKK9
initial concentration: NaN
boundary condition: true
name: NUDT5
type: Species
is: SBO:0000252
initial amount: NaN

metaR NACHEXA16ly
name: beta-N-acetylhexosaminidase A, lysosomal
kinetic law: MODEL1310110014#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
modifier: MODEL1310110014#
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_6d051726_ea56_4191_9ef2_191efb4863b6
has only substance units: false
name: IK
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:3550
type: Species
is: Q13123

metaR r0483
is: SBO:0000176
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
type: Reaction
reactant: MODEL1310110014#
fast: false
reversible: true
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110014#_b4eb72ee_3a1b_416c_967d_d9108b572505
initial amount: NaN
constant: false
is encoded by: hsa:2678
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P19440
has only substance units: false
type: Species
name: GGT1

http://identifiers.org/biomodels.db/MODEL1310110014#_82777b8d_ddc4_4f87_9d30_0e19ec384844
is encoded by: hsa:8801
boundary condition: true
constant: false
type: Species
name: SUCLG2
has only substance units: false
is: Q96I99
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR HIVCACBP
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyisovalerylcoa from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_d7dda044_6fc6_405c_8fd0_7582280c1c48
boundary condition: true
is encoded by: hsa:51102
name: MECR
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q9BV79

metaR UMPK5n
fast: false
reactant: MODEL1310110014#
name: UMP kinase (dATP),nuclear
type: Reaction
kinetic law: MODEL1310110014#
reversible: true
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110014#
is described by: ECO:0000269
is: SBO:0000176

metaR PGK
is: SBO:0000176
is described by: ECO:0000134
reversible: true
fast: false
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.2.3
name: phosphoglycerate kinase
reactant: MODEL1310110014#
type: Reaction
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:

metaM bhb m
initial amount: NaN
has only substance units: false
is: HMDB00011
name: (R)-3-hydroxybutyrate
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
constant: false
is: CHEBI:10983
type: Species

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaR DNDPt36m
is: SBO:0000185
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110014#
fast: false
type: Reaction
name: dGDP transport via dCDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_f3c8b0c0_2cf7_4335_874a_3b608d181a40
is: SBO:0000252
boundary condition: true
is: A5PKZ1
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:11227
name: GALNT5
initial concentration: NaN
has only substance units: false

metaM CE0713 m
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
constant: false
initial concentration: 1.0
is: CHEBI:30623
is: HMDB02329
name: 3-oxolinoleoyl-CoA
boundary condition: false
type: Species

metaR r0281
modifier: MODEL1310110014#
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
is version of: http://identifiers.org/ec-code/5.3.1.6
kinetic law: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110014#
type: Reaction
reversible: true

metaR FAOXC185m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_6c7b42d2_224d_4684_b330_ec3b646a3578
is encoded by: hsa:122970
constant: false
name: ACOT4
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: Q8N9L9

metaR ACTLMO
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (1571.1) SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:stoichiometry described in Thornalley PJ. Gen Pharmacol. 1996 Jun;27(4):565-73. PMID: 8853285 NCD
kinetic law: MODEL1310110014#
is: SBO:0000176
reactant: MODEL1310110014#
reversible: false
type: Reaction
name: acetol monooxygenase
is described by: ECO:0000269
fast: false
product: MODEL1310110014#

metaR SERtN1
modifier: MODEL1310110014#
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
name: Serine transport (Na, H coupled)
product: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
is described by: ECO:0000269

metaR G12MT2 L
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110014#
reversible: false
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
fast: false
reactant: MODEL1310110014#

metaR SMPD4
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110014#
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
fast: false
reversible: false
name: sphingomyelinase

metaM dhf e
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: CHEBI:57451
is: SBO:0000247
is: HMDB01056
initial amount: NaN
boundary condition: false
constant: false
name: dihydrofolate(2-)

metaM acgam l
name: N-acetyl-D-glucosamine
is: SBO:0000247
is: CHEBI:17411
initial amount: NaN
initial concentration: 1.0
is: HMDB00215
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
type: Species
constant: false
has only substance units: false

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaR C180CRNt
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
type: Reaction
fast: false
kinetic law: MODEL1310110014#
name: C180 transport into the mitochondria
is: SBO:0000185
reactant: MODEL1310110014#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110014#

metaR r0280
kinetic law: MODEL1310110014#
product: MODEL1310110014#
fast: false
modifier: MODEL1310110014#
reactant: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
name: dATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_metaR_ACGALFUCGALACGALFUCGALACGLCGAL14ACGLCGALGLUSIDEte
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
fast: false
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: blood group intracellular transport
type: Reaction

metaR IDOAASE3ly
modifier: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
fast: false
name: alpha-L-iduronidase, lysosomal
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.76
reactant: MODEL1310110014#
type: Reaction
reversible: false

metaM o2s c
boundary condition: false
has only substance units: false
is: HMDB02168
name: superoxide
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial amount: NaN
is: CHEBI:18421
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_450b8eed_2354_4972_ac12_bbe0ba9b0722
initial amount: NaN
type: Species
name: GALT
is: B4E097
constant: false
has only substance units: false
is encoded by: hsa:2592
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM phaccoa c
initial amount: NaN
is: CHEBI:57390
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
has only substance units: false
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
name: phenylacetyl-CoA(4-)
is: HMDB06503

metaR PGI
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
fast: false
name: glucose-6-phosphate isomerase
product: MODEL1310110014#
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/5.3.1.9
type: Reaction

metaR EX tetdece1crn
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecenoyl carnitine
type: Reaction

metaR LCYSTAT
is version of: http://identifiers.org/ec-code/2.6.1.1
name: L-Cysteate:2-oxoglutarate aminotransferase
reactant: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:described in PMID: 3346220 and KEGG MM
kinetic law: MODEL1310110014#
is described by: ECO:0000304
is: SBO:0000176
modifier: MODEL1310110014#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_e161349b_e3ad_49b3_ae13_aab060fe71db
is: SBO:0000252
name: SLC35A2
boundary condition: true
is: P78381
initial concentration: NaN
is encoded by: hsa:7355
constant: false
type: Species
has only substance units: false
initial amount: NaN

metaR RE1534M
is described by: ECO:0000000
name: RE1534
product: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
kinetic law: MODEL1310110014#
is: SBO:0000176
reactant: MODEL1310110014#
modifier: MODEL1310110014#

metaR KSII CORE2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
reversible: false
name: keratan sulfate II (core2) transport, golgi to extracellular
type: Reaction
reactant: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000185

metaR EX lneldc LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoelaidic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_34df390c_518f_447b_be27_d45af9ed4a8f
is encoded by: hsa:AI971023
name: _AI971023_1_c
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_47260500_2340_49c6_a7d9_02cf5a234750
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: FDFT1
initial concentration: NaN
is: P37268
boundary condition: true
type: Species
is encoded by: hsa:2222

http://identifiers.org/biomodels.db/MODEL1310110014#_f9e86df7_9e30_4fac_842c_4cb718ecb17e
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
name: PLCB1
is: SBO:0000252
is encoded by: hsa:23236
type: Species
is: Q9NQ66
initial amount: NaN

metaM Rtotal l
name: R total
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:52639
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: CO2FULLR CHARGE: -1
type: Species

metaR EX appnn LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (+)-alpha-Pinene exchange
type: Reaction

metaR RE1836X
is: SBO:0000176
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
modifier: MODEL1310110014#
name: RE1836
fast: false
reactant: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.176
reversible: true

metaM ksi deg39 l
name: keratan sulfate I, degradation product 39
has only substance units: false
is: SBO:0000247
is: CHEBI:12936
is: HMDB00143
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C48H81N3O36 CHARGE: 0

metaR r0480
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
reactant: MODEL1310110014#
is: SBO:0000176
fast: false
type: Reaction
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103

http://identifiers.org/biomodels.db/MODEL1310110014#_2cc6ada1_d3db_426b_ac7c_e026f1d1cbcd
has only substance units: false
initial amount: NaN
is encoded by: hsa:1892
initial concentration: NaN
is: SBO:0000252
is: P30084
constant: false
boundary condition: true
name: ECHS1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_ba11a119_d880_4cb2_a0d8_2da7edab45ec
has part: P38117
type: Species
is encoded by: hsa:2109
is: SBO:0000297
name: ETFA:ETFB
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR FCOAH
type: Reaction
product: MODEL1310110014#
reactant: MODEL1310110014#
name: formyl coa hydrolase
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11341778,PMID:11591435 NOTES:Note - formcoa formula is uncharged - the correct is FACOAH2 w/ forcoa NJ
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110014#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110014#_70533c6d_321b_4ea9_a752_40be8f22aba4
boundary condition: true
is encoded by: hsa:1806
is: Q12882
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: DPYD

metaR FRDPtr
is: SBO:0000185
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
fast: false
reactant: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
is described by: ECO:0000000
reversible: true
name: lipid, flip-flop intracellular transport

metaM docohexcoa x
name: 2,4,7,10,13,16-docosahexenoylcoa
is: http://identifiers.org/pubchem.compound/24892790
constant: false
has only substance units: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaR FATP5t
name: fatty acid electroneutral transport
notes: GENE_ASSOCIATION: (10998.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is version of: http://identifiers.org/ec-code/6.2.1.7
is: SBO:0000185
fast: false
type: Reaction
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000269
product: MODEL1310110014#
reversible: true
kinetic law: MODEL1310110014#

metaM ptth m
initial amount: NaN
has only substance units: false
is: HMDB03426
is: SBO:0000247
boundary condition: false
name: pantetheine
initial concentration: 1.0
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
constant: false
type: Species
is: CHEBI:16753

metaR FAOXC61m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_a23a7609_a96d_41ca_b879_91938ed119d9
has only substance units: false
initial concentration: NaN
is encoded by: hsa:122622
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
boundary condition: true
is: Q8N142
name: ADSSL1

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_metaR_ACGALFUCGALACGALFUCGALACGLCGAL14ACGLCGALGLUSIDEtg
reactant: MODEL1310110014#
product: MODEL1310110014#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is described by: ECO:0000000
reversible: true
name: blood group intracellular transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_e2f5ceea_2dd9_423c_9e2b_24fee86e591c
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
name: ACOX1
is: B4DK61
constant: false
is: SBO:0000252
is encoded by: hsa:51

metaR FAOXC204C184m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_f2ca0803_3009_4438_a376_a70c252d4f56
boundary condition: true
is: SBO:0000252
has only substance units: false
is: P07195
type: Species
initial concentration: NaN
is encoded by: hsa:3945
name: LDHB
initial amount: NaN
constant: false

metaM ksi pre34 g
initial amount: NaN
is: C00130
is: HMDB00175
boundary condition: false
is: SBO:0000247
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
has only substance units: false
type: Species
constant: false
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 34
initial concentration: 1.0

metaR G14T6g
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.22

metaR LNELDCt
kinetic law: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110014#
is described by: ECO:0000000
reversible: true
type: Reaction
name: fatty acid transport via diffusion
fast: false
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_a4471f18_d0d6_4b1c_83f8_6ae74bd02ab7
name: SLC23A2
type: Species
is: Q9UGH3
has only substance units: false
is encoded by: hsa:9962
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_b8af038b_a6a6_4616_a25a_93ceb34d773b
initial amount: NaN
name: ABCC3
is encoded by: hsa:8714
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is: O15438
type: Species

metaM ksii core4 deg3 l
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate II (core 4-linked), degradation product 3
is: HMDB00143
is: CHEBI:12936
is: SBO:0000247
constant: false
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
has only substance units: false

metaM cdpdag hs c
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58332
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
constant: false
type: Species
name: CDP-diacylglycerol(2-)

metaM hdd2coa m
is: CHEBI:61526
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: trans-Hexadec-2-enoyl-CoA
is: C05272
initial amount: NaN
type: Species
constant: false
is: HMDB03945

http://identifiers.org/biomodels.db/MODEL1310110014#_a9b47202_796b_446a_b03d_ca17554af904
constant: false
is: SBO:0000252
name: AGL
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:178
has only substance units: false

metaR URIt5le
reversible: false
name: uridine transport in via sodium symport (1:2)
kinetic law: MODEL1310110014#
type: Reaction
fast: false
reactant: MODEL1310110014#
is described by: ECO:0000134
modifier: MODEL1310110014#
is: SBO:0000185
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR H6ET3er
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
is described by: ECO:0000000
fast: false
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
modifier: MODEL1310110014#
is: SBO:0000176
reactant: MODEL1310110014#
product: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.1

metaM q10h2 c
initial concentration: 1.0
type: Species
is: HMDB13111
initial amount: NaN
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/6504740
boundary condition: false
name: Ubiquinol-10
has only substance units: false

metaR GLYCTO1p
product: MODEL1310110014#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
kinetic law: MODEL1310110014#
fast: false
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.3.15
modifier: MODEL1310110014#
name: Glycolate oxidase, peroxisome
reactant: MODEL1310110014#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110014#_metaR_EX_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIAb exchange
type: Reaction

metaR SERGLNexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-Serine/Glutamine reversible exchange
is described by: ECO:0000304
modifier: MODEL1310110014#
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110014#
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction

metaR FAOXC101C8x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8:0)x
type: Reaction

metaR HOXG
is described by: ECO:0000134
fast: false
type: Reaction
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000176
name: Heme oxygenase 1
product: MODEL1310110014#
reversible: false
is version of: http://identifiers.org/ec-code/1.14.99.3
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme

metaR GLNATB0tc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of L-Glutamine into the intestinal cells by ATB0 transporter
type: Reaction

metaM orot5p c
constant: false
name: Orotidine 5'-phosphate
type: Species
is: C01103
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
has only substance units: false
initial concentration: 1.0
is: HMDB00218
is: SBO:0000247
is: CHEBI:57538

metaR EICOSTETCRNt
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
product: MODEL1310110014#
reversible: false
fast: false
reactant: MODEL1310110014#
type: Reaction
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000185
is described by: ECO:0000000

metaR r1658
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110014#
is described by: ECO:0000000

metaR MANtly
is: SBO:0000185
reversible: false
name: mannose efflux from lysosome
kinetic law: MODEL1310110014#
fast: false
is described by: ECO:0000000
product: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD

metaM gua e
is: HMDB00132
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: guanine
initial amount: NaN
is: CHEBI:16235

metaM HC01434 m
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: oxalatosuccinate(3-)
boundary condition: false
is: CHEBI:58931
type: Species
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
constant: false

metaM hmgcoa m
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Hydroxymethylglutaryl-CoA
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: HMDB01375
is: CHEBI:15467
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_7b4c6d9a_caf8_4f76_8130_57a9f7eb1d98
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: ND4L
constant: false
is: Q7GXZ4
is: SBO:0000252
is encoded by: hsa:4539
type: Species

metaR VACCCRNt
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
reversible: false
product: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false

metaR r0130
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
reversible: true
modifier: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110014#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
type: Reaction
kinetic law: MODEL1310110014#
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_77d674be_0ddb_494e_925d_9526ffc9dd1b
is encoded by: hsa:4719
has only substance units: false
is: P28331
initial concentration: NaN
is: SBO:0000252
name: NDUFS1
boundary condition: true
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_6e81b2df_a994_4923_ace1_192c6eb554c6
is: Q86SF2
boundary condition: true
initial concentration: NaN
name: GALNT7
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:51809
has only substance units: false

metaM dhf c
constant: false
name: 7,8-Dihydrofolate
is: C00415
is: SBO:0000247
is: HMDB01056
type: Species
boundary condition: false
is: CHEBI:57451
initial concentration: 1.0
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial amount: NaN
has only substance units: false

metaR r1659
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
modifier: MODEL1310110014#
type: Reaction
is: SBO:0000185
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_ee4064c0_400b_4ac7_8c8f_0fff23358764
has only substance units: false
is: Q6GTM5
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:6309
type: Species
is: SBO:0000252
initial concentration: NaN
name: SC5DL

metaM CE4795 x
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,18-21,28-30,34-36,40,51-52H,4-7,10,13,16-17,22-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,19-18-,21-20+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4795
is: CHEBI:57923
has only substance units: false
name: 2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA

metaM q10h2 e
name: Ubiquinol-10
has only substance units: false
is: HMDB13111
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/6504740
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
boundary condition: false

metaR EX dmhptcrn LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2,6 dimethylheptanoyl carnitine exchange
type: Reaction

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaM acgam r
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: HMDB00215
name: N-acetyl-D-glucosamine
is: CHEBI:17411

metaM lac D e
constant: false
initial concentration: 1.0
name: (R)-lactate
is: HMDB01311
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
boundary condition: false
has only substance units: false
is: CHEBI:16004

metaM thr L c
constant: false
name: L-threonine
boundary condition: false
initial concentration: 1.0
is: CHEBI:16857
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: HMDB00167
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_836e169b_a0dd_4eaa_9d5f_af2ca85cdc66
is encoded by: hsa:79369
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
name: B3GNT4
constant: false
is: Q9C0J1
initial amount: NaN

metaM bhb e
is: SBO:0000247
is: HMDB00011
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
type: Species
name: (R)-3-hydroxybutyrate
initial amount: NaN
has only substance units: false
is: CHEBI:10983
boundary condition: false
initial concentration: 1.0
constant: false

metaR DOPASFt
type: Reaction
reversible: false
product: MODEL1310110014#
is described by: ECO:0000000
kinetic law: MODEL1310110014#
fast: false
name: Dopamine 3-0-sulfate transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
is: SBO:0000185
reactant: MODEL1310110014#

metaR MMSAD3m
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
reversible: false
kinetic law: MODEL1310110014#
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
fast: false
product: MODEL1310110014#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.27
modifier: MODEL1310110014#
is described by: ECO:0000269

metaR O2St
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110014#
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000000
name: superoxide anion transport via diffusion (extracellular)
fast: false

metaM gua c
is: CHEBI:16235
is: C00242
initial concentration: 1.0
name: Guanine
initial amount: NaN
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: SBO:0000247
constant: false
type: Species
has only substance units: false
is: HMDB00132
boundary condition: false

metaM ksi deg33 l
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
type: Species
constant: false
is: HMDB00143
name: keratan sulfate I, degradation product 33
is: CHEBI:12936
has only substance units: false
initial amount: NaN

metaR r1656
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110014#
is described by: ECO:0000000
modifier: MODEL1310110014#

metaM cholcoaone x
is: CHEBI:58507
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
constant: false
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
is: HMDB06891

http://identifiers.org/biomodels.db/MODEL1310110014#_64430389_05ad_4fe2_90c2_fb201a641056
initial amount: NaN
constant: false
is: SBO:0000297
is encoded by: hsa:51227
has only substance units: false
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
boundary condition: true
initial concentration: NaN
type: Species

metaM decdicrn e
constant: false
is: HMDB13325
has only substance units: false
notes: FORMULA: C17H29NO4 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
name: decadienoyl carnitine
boundary condition: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_69dee24e_f1ed_4445_963e_c85af69ae596
initial concentration: NaN
has only substance units: false
name: ALG3
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:10195
boundary condition: true
is: SBO:0000252

metaR r1431
type: Reaction
product: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110014#
reversible: false
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
fast: false
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:

metaR FAOXC142C122m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

metaR MM5cg
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
reversible: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.113
product: MODEL1310110014#
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_8686db03_ea38_47e5_91e7_c8002184563b
type: Species
is encoded by: hsa:5169
name: ENPP3
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q308M7

http://identifiers.org/biomodels.db/MODEL1310110014#_534b18cc_57a9_406e_9cce_e8b1b62ba8c7
initial concentration: NaN
is encoded by: hsa:125965
constant: false
boundary condition: true
is: Q6YFQ2
initial amount: NaN
name: COX6B2
is: SBO:0000252
type: Species
has only substance units: false

metaR SERt4
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000185
type: Reaction
name: L-serine via sodium symport
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
is described by: ECO:0000269
fast: false
reversible: false
modifier: MODEL1310110014#

metaR r0377
is described by: ECO:0000000
product: MODEL1310110014#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: false
reactant: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
modifier: MODEL1310110014#

metaR r1657
reversible: true
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
modifier: MODEL1310110014#
type: Reaction
fast: false
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_0f411ec6_e77d_4694_8f4a_3ce2d5ce7867
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR PTDCAt
fast: false
kinetic law: MODEL1310110014#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: fatty acid transport via diffusion
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
type: Reaction
reactant: MODEL1310110014#

metaR r1654
modifier: MODEL1310110014#
reversible: true
reactant: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110014#

metaR FAOXC61x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)x
type: Reaction

metaR r0287
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
type: Reaction
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
kinetic law: MODEL1310110014#
product: MODEL1310110014#
modifier: MODEL1310110014#

metaM ksii core4 pre3 g
name: keratan sulfate II biosynthesis, precursor 3
notes: FORMULA: C55H89N5O38X CHARGE: -1
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00175
initial concentration: 1.0
type: Species
is: C00130
is: CHEBI:58053

metaM bhb c
is: CHEBI:10983
name: (R)-3-hydroxybutyrate
boundary condition: false
is: HMDB00011
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR CYOOm3
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
name: cytochrome c oxidase, mitochondrial Complex IV
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.9.3.1
kinetic law: MODEL1310110014#
is described by: ECO:0000134
product: MODEL1310110014#

metaM succoa x
name: Succinyl-CoA
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB01022
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5

metaM udpglcur r
is: CHEBI:58052
constant: false
initial concentration: 1.0
has only substance units: false
is: C00167
initial amount: NaN
is: SBO:0000247
is: HMDB00935
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
type: Species
boundary condition: false
name: UDP-D-glucuronate

metaM accoa c
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
name: Acetyl-CoA
initial concentration: 1.0
is: C00024
has only substance units: false
type: Species
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: HMDB01206
is: CHEBI:57288

http://identifiers.org/biomodels.db/MODEL1310110014#_fee5000e_80c9_4288_a569_8a632f35c877
constant: false
is: SBO:0000252
initial amount: NaN
is: P49189
is encoded by: hsa:223
initial concentration: NaN
name: ALDH9A1
type: Species
boundary condition: true
has only substance units: false

metaM tetpent6 c
is: HMDB06322
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
name: tetracosapentaenoic acid, n-6

metaR PPPG9tm
reversible: true
reactant: MODEL1310110014#
type: Reaction
fast: false
product: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000185
name: protoporphyrinogen IX mitochondrial transport
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:14623258 NOTES:NCD. Benzodiazepine receptor PBR see also 17168567

metaR SERDGLYexR
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000304
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110014#
name: D-Serine/Glycine reversible exchange
modifier: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#

metaR GALGALGALTHCRMtg
product: MODEL1310110014#
is described by: ECO:0000000
name: galgalgalthcrm hs intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
fast: false
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_f1bc2a62_3fe3_4048_b66d_a28e2b720d94
initial concentration: NaN
name: ACSS1
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q9NUB1
has only substance units: false
is encoded by: hsa:84532
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_99b103a7_1d0e_4722_a44c_ba409a838d1b
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:128
boundary condition: true
is: Q6IRT1
name: ADH5
constant: false
is: SBO:0000252
initial amount: NaN

metaR r1655
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110014#
reversible: true
is: SBO:0000185

metaM adprib c
is: SBO:0000247
has only substance units: false
constant: false
type: Species
notes: FORMULA: C15H21N5O14P2 CHARGE: -2 EHMN_ABBREVIATION: C00301
is: HMDB01178
name: ADPribose
initial amount: NaN
is: CHEBI:57967
initial concentration: 1.0
boundary condition: false
is: C00301

metaM malt e
boundary condition: false
is: HMDB00163
is: CHEBI:17306
initial amount: NaN
initial concentration: 1.0
is: C00208
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
type: Species
has only substance units: false
is: SBO:0000247
name: Maltose
constant: false

metaM ksi deg30 l
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
is: SBO:0000247
is: CHEBI:12936
name: keratan sulfate I, degradation product 30
initial concentration: 1.0
initial amount: NaN
is: HMDB00143
constant: false
type: Species
has only substance units: false
boundary condition: false

metaM decdicrn c
boundary condition: false
is: HMDB13325
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C17H29NO4 CHARGE: 0
name: decadienoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110014#_ddd4f436_5d55_433f_a1b0_ccd2ad499b8d
is: SBO:0000252
constant: false
is: P13073
boundary condition: true
initial concentration: NaN
has only substance units: false
name: COX4I1
is encoded by: hsa:1327
initial amount: NaN
type: Species

metaR AG13T11g
modifier: MODEL1310110014#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_f294c991_f014_4afc_ab1e_0ce63057efa7
constant: false
boundary condition: true
initial concentration: NaN
is: Q546Y9
name: AICDA
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:57379
has only substance units: false
type: Species

metaR r1754
modifier: MODEL1310110014#
name: Y+LAT2 Utilized transport
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000185
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_57f41078_d8ae_4543_b5c7_118148fa16d7
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: P00326
type: Species
is encoded by: hsa:126
boundary condition: true
name: ADH1C
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_ffcb5091_d7c9_4259_8837_72f51734346f
is: B4DYG5
initial concentration: NaN
name: PI4KA
is encoded by: hsa:5297
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
constant: false

metaR TYRTA
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.1
name: tyrosine transaminase
modifier: MODEL1310110014#
reversible: true
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is: SBO:0000176
fast: false

metaR FAOXC161C141x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C16:1-->C14:1)x
type: Reaction

metaM 2amac c
name: 2-aminoacrylic acid
boundary condition: false
notes: FORMULA: C3H5NO2 CHARGE: 0 INCHI: InChI=1S/C3H5NO2/c1-2(4)3(5)6/h1,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00906 EHMN_ABBREVIATION: C02218
is: SBO:0000247
initial amount: NaN
is: HMDB03609
has only substance units: false
is: CHEBI:17123
type: Species
initial concentration: 1.0
constant: false

metaM ksi deg17 l
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
is: CHEBI:12936
initial amount: NaN
name: keratan sulfate I, degradation product 17
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00143
constant: false

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR r2390
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110014#
product: MODEL1310110014#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false

metaR C4CRNCPT2
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of butyryl carnitine in the mitochondrial matrix for final hydrolysis
type: Reaction

metaM ctdecdcoa m
initial concentration: 1.0
name: cis2trans4decadienoylcoa
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00792
is: C08277

metaR DOLPMT4 Ler
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110014#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
is: SBO:0000185
kinetic law: MODEL1310110014#
is described by: ECO:0000000
fast: false
product: MODEL1310110014#
type: Reaction
reversible: false

metaR HSD3A2r
is version of: http://identifiers.org/ec-code/1.1.1.225
type: Reaction
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is described by: ECO:0000000
reactant: MODEL1310110014#
modifier: MODEL1310110014#
fast: false
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
product: MODEL1310110014#

metaR GALGALGALTHCRMte
is described by: ECO:0000000
name: galgalgalthcrm hs transport
kinetic law: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
is: SBO:0000185
fast: false
reactant: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ

metaR r1652
reversible: true
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110014#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
product: MODEL1310110014#

metaM HC01434 c
constant: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial concentration: 1.0
is: CHEBI:58931
name: oxalatosuccinate(3-)
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247

metaR OLEICFATPtc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

metaR L LACt2r
fast: false
reactant: MODEL1310110014#
is: SBO:0000185
name: L-lactate reversible transport via proton symport
product: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110014#
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_a319ac22_ba5e_416a_b862_b33404e91274
name: ACSS2
is encoded by: hsa:55902
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: Q5QPH3
initial concentration: NaN

metaM fald m
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:16842
is: HMDB01426
is: SBO:0000247
name: formaldehyde
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_28e8d962_ae2c_4dd3_a358_6d58b56ff96a
name: CHAT
initial amount: NaN
constant: false
is encoded by: hsa:1103
is: Q6LEN6
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true

metaR ALDD2y
is described by: ECO:0000000
kinetic law: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.36
modifier: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
reactant: MODEL1310110014#
name: aldehyde dehydrogenase (acetaldehyde, NADP)
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110014#_24ccec5a_e0ac_4ab3_90e6_d59e47f2d967
constant: false
name: MYO5B
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4645
initial amount: NaN
type: Species
has only substance units: false
is: Q9H6Y6
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_434e2faf_e920_45da_bd85_b855c67395d7
boundary condition: true
is: Q08828
has only substance units: false
name: ADCY1
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:107
is: SBO:0000252
initial concentration: NaN

metaM glyc S e
is: CHEBI:33871
is: HMDB06372
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: (S)-Glycerate
constant: false
notes: FORMULA: C3H5O4 CHARGE: 0
boundary condition: false

metaR 2OXOADPTm
kinetic law: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
is: SBO:0000185
fast: false
reactant: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110014#
name: 2-oxoadipate shuttle (cytosol/mitochondria)

metaM lnlncgcrn c
is: SBO:0000247
type: Species
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
name: gamma-linolenyl carnitine
has only substance units: false
is: HMDB06318

metaR DHCR243r
reversible: false
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000134
name: 24-dehydrocholesterol reductase [Precursor]
fast: false
reactant: MODEL1310110014#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
is version of: http://identifiers.org/ec-code/1.3.1.72

metaM glygn4 e
boundary condition: false
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
is: HMDB00122
type: Species
notes: FORMULA: C18H31O16X CHARGE: 0
is: CHEBI:4167
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN

metaR r1653
is: SBO:0000185
kinetic law: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110014#
is described by: ECO:0000000
modifier: MODEL1310110014#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR GALt1r
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD
is: SBO:0000185
type: Reaction
reactant: MODEL1310110014#
is described by: ECO:0000269
reversible: true
fast: false
product: MODEL1310110014#
name: galactose transport (uniport)
modifier: MODEL1310110014#

metaR ALDD2x
type: Reaction
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110014#
product: MODEL1310110014#
name: aldehyde dehydrogenase (acetaldehyde, NAD)
is: SBO:0000176
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.36
is described by: ECO:0000000

metaR DOLPGT1 Ler
modifier: MODEL1310110014#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
is version of: http://identifiers.org/ec-code/2.4.1.267
reversible: false
fast: false
reactant: MODEL1310110014#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
product: MODEL1310110014#

metaM ade e
boundary condition: false
has only substance units: false
name: adenine
is: SBO:0000247
is: HMDB00034
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: CHEBI:16708

metaM glyc3p x
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: Glycerol 3-phosphate
has only substance units: false
is: C00093
initial amount: NaN
type: Species
is: CHEBI:57597
is: HMDB00126
constant: false

metaR HSAT4ly
is: SBO:0000185
fast: false
name: heparan-glucosaminide N-acetyltransferase, lysosomal
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000000
type: Reaction
reversible: false
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD

metaR TETTET6COAtx
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110014#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
name: fatty acid intracellular transport
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_807dce89_27d3_4ad6_b639_a7332f7e7e2c
has only substance units: false
is encoded by: hsa:AA177072
is: SBO:0000252
name: _AA177072_1_x
constant: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN

metaR r1650
modifier: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true
product: MODEL1310110014#
type: Reaction
fast: false
kinetic law: MODEL1310110014#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM thr L e
name: L-threonine
initial amount: NaN
constant: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: CHEBI:16857
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00167

metaM lac D c
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
has only substance units: false
name: (R)-lactate
is: HMDB01311
is: CHEBI:16004
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM dolmanp L c
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:15809
constant: false
type: Species
name: Dolichyl phosphate D-mannose, human liver homolog
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial amount: NaN
is: SBO:0000247

metaM pail hs n
initial amount: NaN
is: SBO:0000247
is: CHEBI:57880
name: 1-phosphatidyl-1D-myo-inositol(1-)
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_36bfc5c1_d287_4ecd_92f1_5ea90df577ba
is: SBO:0000252
is: Q9H0P0
is encoded by: hsa:51251
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: NaN
name: NT5C3
boundary condition: true

metaR DOLPMT1 Ler
is version of: http://identifiers.org/ec-code/2.4.1.258
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
reversible: false
reactant: MODEL1310110014#
modifier: MODEL1310110014#
product: MODEL1310110014#
fast: false

metaR PRODt2r
is described by: ECO:0000304
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
name: D-proline reversible transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
product: MODEL1310110014#
fast: false
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_4eafac92_c2c0_4163_8d99_143500831413
is: Q9H2F3
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
name: HSD3B7
initial amount: NaN
is encoded by: hsa:80270

metaR MMEm
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.1.99.1
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
name: methylmalonyl-CoA epimerase/racemase
product: MODEL1310110014#
fast: false

metaM accoa g
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57288
type: Species
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
name: acetyl-CoA(4-)
initial amount: NaN
boundary condition: false
is: HMDB01206

metaR C161OHc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecenoylcarnitine
type: Reaction

metaR INSTt4 2
modifier: MODEL1310110014#
is described by: ECO:0000006
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
type: Reaction
product: MODEL1310110014#
reversible: true
name: inositol transport via sodium symport
reactant: MODEL1310110014#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110014#

metaM glyc S c
is: CHEBI:33871
is: SBO:0000247
is: HMDB06372
initial concentration: 1.0
name: (S)-Glycerate
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C3H5O4 CHARGE: 0
type: Species

metaM q10h2 m
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/6504740
name: Ubiquinol-10
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB13111

metaR r1651
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000000
modifier: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_4d5c48fb_814e_4817_ae69_94acf1c86018
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:4842
name: NOS1
is: B4DG68
initial concentration: NaN

metaR OCTDECCACT
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaM tetdece1coa c
constant: false
is: HMDB05066
initial amount: NaN
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
has only substance units: false
type: Species
name: tetradecenoylcoa
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM ade c
name: Adenine
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: C00147
is: SBO:0000247
is: HMDB00034
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: CHEBI:16708
has only substance units: false
boundary condition: false

metaM hdd2coa c
is: C05272
is: HMDB03945
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
boundary condition: false
is: CHEBI:61526
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: trans-Hexadec-2-enoyl-CoA

metaR DGAT
is version of: http://identifiers.org/ec-code/2.3.1.20
reversible: false
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
type: Reaction
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000000
product: MODEL1310110014#
is: SBO:0000176
name: diacylglycerol acyltransferase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_ce7e739a_509b_4fe3_9e32_aa3514e2e2d9
has only substance units: false
name: SDHB
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6390
type: Species
is: P21912
constant: false

metaR r1449
reactant: MODEL1310110014#
reversible: false
kinetic law: MODEL1310110014#
name: EC:1.3.3.6
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
is: SBO:0000176
fast: false
product: MODEL1310110014#

metaR TYMSFt
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
is: SBO:0000185
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
name: Tyramine O-sulfate transport (diffusion)
fast: false
product: MODEL1310110014#

metaR DALAxt
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: D-Alanine transport to perixosome
reactant: MODEL1310110014#
reversible: false
fast: false
kinetic law: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB

metaR RNDR4
is: SBO:0000176
reactant: MODEL1310110014#
name: ribonucleoside-diphosphate reductase (UDP)
product: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
reversible: false
is described by: ECO:0000254
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
modifier: MODEL1310110014#

metaR r2399
kinetic law: MODEL1310110014#
type: Reaction
fast: false
reactant: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110014#

metaR RE2988X
name: RE2988
type: Reaction
kinetic law: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110014#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110014#

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaM dag hs c
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
name: diglyceride
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:18035
has only substance units: false

metaR LYStn
is: SBO:0000185
fast: false
kinetic law: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
name: L-lysine transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true

metaR RBTt
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
name: ribitol transport via passive diffusion
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110014#_a670b560_ec7d_4abc_87d6_47ed812971b1
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:6581
is: Q5SYN6
initial amount: NaN
name: SLC22A3
is: SBO:0000252

metaM pail4p hs c
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
initial concentration: 1.0
is: CHEBI:58178
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: SBO:0000247

metaM adrncrn c
boundary condition: false
name: Adrenyl carnitine
notes: FORMULA: C29H49NO4 CHARGE: 0
is: C00318
initial amount: NaN
is: CHEBI:16347
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00062

http://identifiers.org/biomodels.db/MODEL1310110014#_d943eef8_eae6_45e0_b155_6403233fc193
boundary condition: true
constant: false
name: CA3
is: P07451
is: SBO:0000252
is encoded by: hsa:761
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

metaM cit e
is: SBO:0000247
is: CHEBI:16947
initial concentration: 1.0
name: citrate(3-)
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
type: Species
is: HMDB00094
boundary condition: false

metaR SO4t4 2
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
name: sulfate transport via sodium symport
is described by: ECO:0000269
reversible: true
product: MODEL1310110014#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false

metaM fald c
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
name: formaldehyde
has only substance units: false
is: CHEBI:16842
boundary condition: false
constant: false
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
is: HMDB01426

metaM oagd3 hs e
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
name: 9-O-Acetylated GD3
constant: false
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
is: HMDB02168
is: CHEBI:18421
initial amount: NaN
initial concentration: 1.0

metaM ksii core2 deg7 l
constant: false
is: SBO:0000247
is: CHEBI:16953
notes: FORMULA: C44H73N4O30X CHARGE: 0
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 7
is: HMDB00812
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_f43fd055_5dde_4e74_8e70_eea3bf6a4ea6
name: FADS2
is: O95864
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:9415

metaR LYStm
is described by: ECO:0000269
modifier: MODEL1310110014#
name: Lysine mitochondrial transport via ornithine carrier
type: Reaction
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
product: MODEL1310110014#
is: SBO:0000185
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_ae54cae7_5458_48c5_ba7c_05268cd304d0
is: SBO:0000252
is: P05091
name: ALDH2
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:217
initial amount: NaN
has only substance units: false

metaR RE1518M
modifier: MODEL1310110014#
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.13
is described by: ECO:0000000
is: SBO:0000176
name: RE1518

metaR GLXtp
type: Reaction
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
is: SBO:0000185
name: glyoxylate transport, peroxisomal
fast: false
is described by: ECO:0000000
reactant: MODEL1310110014#
product: MODEL1310110014#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_ef8c7b25_411b_4afb_8a6c_c37aed993ecb
has only substance units: false
is encoded by: hsa:117248
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
name: GALNTL2
is: Q8N3T1

metaM h g
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
has only substance units: false
constant: false
is: SBO:0000247
name: proton
is: CHEBI:24636

metaM CE5121 m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
has only substance units: false
constant: false
name: trans-3-decenoyl-CoA
is: SBO:0000247
is: CHEBI:57449
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false

metaR RNDR2
kinetic law: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
is: SBO:0000176
reactant: MODEL1310110014#
reversible: false
name: ribonucleoside-diphosphate reductase (GDP)
is described by: ECO:0000254
type: Reaction
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_edd8d108_3ddc_476a_8c49_864f3a073ff1
boundary condition: true
initial amount: NaN
name: NDUFA9
is: SBO:0000252
is encoded by: hsa:4704
has only substance units: false
is: Q16795
initial concentration: NaN
constant: false
type: Species

metaR A4GNT2g
product: MODEL1310110014#
modifier: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (51146.1) SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10430883 NOTES:EC 2.4.1.- NCD
type: Reaction
name: alpha 1,4-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
kinetic law: MODEL1310110014#

metaR RNDR1
is: SBO:0000176
name: ribonucleoside-diphosphate reductase (ADP)
fast: false
kinetic law: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
is described by: ECO:0000254
product: MODEL1310110014#
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: false
reactant: MODEL1310110014#

metaM ascb L e
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
name: L-ascorbate
initial concentration: 1.0
is: HMDB00044
has only substance units: false
is: CHEBI:38290

metaR r1661
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110014#
reversible: true
type: Reaction
reactant: MODEL1310110014#
is described by: ECO:0000000

metaR H2Otp
name: H2O transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000000
fast: false
product: MODEL1310110014#
is: SBO:0000185
reversible: true

metaR HSD17B42x
reactant: MODEL1310110014#
is: SBO:0000176
name: hydroxysteroid (17-beta) dehydrogenase 4
product: MODEL1310110014#
reversible: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false

metaR G14T17g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110014#
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
fast: false

metaR r0584
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
modifier: MODEL1310110014#
product: MODEL1310110014#
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
reactant: MODEL1310110014#

metaM oagd3 hs c
is: CHEBI:17315
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
name: 9-O-Acetylated GD3
has only substance units: false
is: HMDB01514
boundary condition: false
is: C00329
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN

metaM gly e
name: Glycine
has only substance units: false
initial amount: NaN
is: CHEBI:3339
constant: false
initial concentration: 1.0
is: HMDB00123
boundary condition: false
notes: FORMULA: C2H5NO2 CHARGE: 0
is: SBO:0000247
type: Species
is: C00037

http://identifiers.org/biomodels.db/MODEL1310110014#_e2454f30_ae88_4b66_95a1_f3c5f213738d
initial amount: NaN
type: Species
is encoded by: hsa:AA614647
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: _AA614647_1_c
boundary condition: true

metaR RE2651R
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110014#
name: RE2651
product: MODEL1310110014#
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:

metaM cspg a e
is: HMDB00300
type: Species
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
is: CHEBI:17568
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: C00106
constant: false
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
initial concentration: 1.0

metaR GLYC3Ptmc
product: MODEL1310110014#
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
name: glycerol-3-phopshate transport, cytoplasm
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: added during gap filling. No evidence found for such a reaction. NOTES:added during gap filling. No evidence found for such a reaction.
type: Reaction
is described by: ECO:0000134
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110014#_fba7d5d0_cc9f_4f98_a5e8_a3f498f40f01
has only substance units: false
type: Species
initial amount: NaN
name: AGPAT4
is encoded by: hsa:56895
is: Q9NRZ5
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN

metaR PPBNGS
kinetic law: MODEL1310110014#
product: MODEL1310110014#
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000176
notes: GENE_ASSOCIATION: (210.1) or (210.2) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.24 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.24
name: porphobilinogen synthase
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110014#_4d0dc13d_b37d_4909_b1f4_13ac199866d9
is encoded by: hsa:80308
has only substance units: false
is: Q8NFF5
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
name: FLAD1
initial amount: NaN

metaR r1660
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110014#
reversible: true
is: SBO:0000185
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#

metaR FUMtm
fast: false
modifier: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000269
reversible: true
name: fumarate transport, mitochondrial
is: SBO:0000185
product: MODEL1310110014#

metaM c10crn e
initial concentration: 1.0
name: decanoyl carnitine
notes: FORMULA: C17H33NO4 CHARGE: 0
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
is: HMDB00651
constant: false
initial amount: NaN

metaM h m
is: SBO:0000247
name: proton
is: CHEBI:24636
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: C00080
type: Species
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
constant: false

metaM triodthy e
is: CHEBI:18258
is: HMDB00265
has only substance units: false
name: 3,3',5-triiodo-L-thyronine
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
is: SBO:0000247
initial amount: NaN

metaR GLXtm
reversible: true
type: Reaction
name: glyoxylate transport, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
fast: false
is: SBO:0000185
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110014#_bafa581a_e908_46f8_a2cc_9580b35b1997
initial concentration: NaN
name: PPAP2A
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is: G3XA95
is encoded by: hsa:8611
initial amount: NaN
constant: false

metaR r1445
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
product: MODEL1310110014#
is described by: ECO:0000000
name: EC:1.3.3.6
type: Reaction
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:

metaM tyr L c
constant: false
name: L-tyrosine
initial amount: NaN
is: HMDB00158
is: CHEBI:17895
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial concentration: 1.0
has only substance units: false

metaM ascb L c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00044
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
name: L-ascorbate
is: CHEBI:38290

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR EX estradiol LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: estradiol exchange
type: Reaction

metaR r2395
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
product: MODEL1310110014#
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
reversible: false

metaR LEUKTRF4t
is described by: ECO:0000000
kinetic law: MODEL1310110014#
product: MODEL1310110014#
fast: false
reversible: true
is: SBO:0000185
name: leukotriene F4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110014#

metaR DHFR
reversible: true
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.5.1.3
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
fast: false
is: SBO:0000176
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
name: dihydrofolate reductase
modifier: MODEL1310110014#
is described by: ECO:0000254

metaM h n
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:24636
boundary condition: false
initial amount: NaN
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species

metaM gly c
constant: false
initial concentration: 1.0
is: C00037
is: SBO:0000247
is: CHEBI:3339
has only substance units: false
is: HMDB00123
initial amount: NaN
boundary condition: false
type: Species
name: Glycine
notes: FORMULA: C2H5NO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110014#_54e40a1a_dff8_46ff_b68a_50662e19b03c
constant: false
is: P19801
is encoded by: hsa:26
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
name: ABP1
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_c7fe1361_e1b7_4df7_bcde_c26f30eeddaf
initial amount: NaN
initial concentration: NaN
is: Q8WUX1
is: SBO:0000252
constant: false
boundary condition: true
name: SLC38A5
type: Species
has only substance units: false
is encoded by: hsa:92745

http://identifiers.org/biomodels.db/MODEL1310110014#_d844b1a3_227d_4659_8c9c_0f3b2fb54848
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is: O43772
has only substance units: false
name: SLC25A20
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:788

metaM citr L e
type: Species
is: SBO:0000247
is: HMDB00904
name: citr_L[e]
initial amount: NaN
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: CHEBI:16349
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_ac437631_56cb_48d3_8988_572e36c5fe09
name: MAN1A1
type: Species
is: P33908
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:4121
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_84a4bfb6_da94_49c6_a70d_81bf0a3c6dfc
name: ST3GAL1
initial amount: NaN
has only substance units: false
is: Q11201
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
constant: false
is encoded by: hsa:6482

metaR r1444
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
kinetic law: MODEL1310110014#
name: EC:1.3.3.6
product: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
fast: false
type: Reaction
is: SBO:0000176
reversible: false

metaM elaid c
name: elaidate
is: HMDB00573
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:30825
is: SBO:0000247
type: Species
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_bed47e97_cf76_4f72_a418_a91573b494a1
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
name: ACSL6
is: B2RB13
is encoded by: hsa:23305
initial concentration: NaN

metaR EBP1r
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.3.5
fast: false
product: MODEL1310110014#
name: 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase
notes: GENE_ASSOCIATION: (10682.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 4 AUTHORS: PMID:10391219 NOTES:involved in lanosterol -> cholesterol pathway NJ
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000176
reactant: MODEL1310110014#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_21336f74_d387_40bd_b2e8_b8aab070ba80
type: Species
initial amount: NaN
is: P49619
name: DGKG
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:1608
boundary condition: true

metaR METLEUex
product: MODEL1310110014#
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (6520.1 and 8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
reversible: false
name: Methionine/Leucine exchange (Met in)
fast: false
type: Reaction
reactant: MODEL1310110014#
modifier: MODEL1310110014#

metaM c10crn c
name: decanoyl carnitine
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C17H33NO4 CHARGE: 0
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00651

http://identifiers.org/biomodels.db/MODEL1310110014#_2097ebd3_ef88_4bb7_8551_d2634db1e70c
name: SGPP1
is: SBO:0000252
has only substance units: false
is encoded by: hsa:81537
constant: false
type: Species
initial concentration: NaN
is: Q9BX95
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_1f50408c_372f_4647_bee9_d668abe41ff8
is: P16219
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:35
constant: false
initial amount: NaN
boundary condition: true
name: ACADS

metaR CYTK2n
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reversible: true
reactant: MODEL1310110014#
fast: false
is described by: ECO:0000269
type: Reaction
name: cytidylate kinase (dCMP),nuclear
product: MODEL1310110014#

metaM 3octdectecoa m
type: Species
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
name: 3,6,9,12-octadecatetraenoylcoa
is: http://identifiers.org/pubchem.compound/5280355
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_d669d35a_da75_4329_a056_a8f72a321f55
type: Species
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: Q7LG56
is: SBO:0000252
name: RRM2B
has only substance units: false
is encoded by: hsa:50484

metaM tettet6coa x
name: tetracosatetraenoyl coenzyme A
initial concentration: 1.0
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
boundary condition: false
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/47205481
has only substance units: false
is: SBO:0000247
is: HMDB06516
initial amount: NaN
is: C16171

metaM tyr L e
initial amount: NaN
has only substance units: false
is: HMDB00158
name: L-tyrosine
is: CHEBI:17895
is: SBO:0000247
boundary condition: false
type: Species
constant: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial concentration: 1.0

metaR EX nrvnc LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nervonic acid exchange
type: Reaction

metaR RE0691C
fast: false
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
name: RE0691
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
product: MODEL1310110014#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

metaM 2hexdtetcoa m
is: SBO:0000247
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
name: 2,7,10,13-hexadecatetraenoylcoa
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB02288

metaR PGISr
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ
name: Prostaglandin I2 synthase
modifier: MODEL1310110014#
reversible: true
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.99.4
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110014#

metaM docohexcoa m
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
name: 2,4,7,10,13,16-docosahexenoylcoa
has only substance units: false
constant: false

metaM fald e
constant: false
is: CHEBI:16842
name: formaldehyde
has only substance units: false
initial amount: NaN
is: HMDB01426
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067

metaM h l
notes: FORMULA: H CHARGE: 1 INCHI: "
initial concentration: 1.0
constant: false
is: C00080
is: http://identifiers.org/pubchem.compound/3380
name: proton
boundary condition: false
is: CHEBI:24636
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false

metaM cit c
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00094
is: CHEBI:16947
name: Citrate
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: C00158
constant: false
boundary condition: false
is: SBO:0000247

metaR ACACT1x
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
reversible: false
name: acetyl-CoA C-acetyltransferase, mitochondrial
is: SBO:0000176
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
is version of: http://identifiers.org/ec-code/2.3.1.9

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaR r0580
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110014#
reversible: true
modifier: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.7
product: MODEL1310110014#
is: SBO:0000176
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_6edf6158_0638_4fc9_90a9_2e426fac9ec0
has only substance units: false
name: GMPR
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2766
constant: false
type: Species
boundary condition: true
initial amount: NaN
is: P36959

metaR AMCOXO
reversible: false
reactant: MODEL1310110014#
fast: false
product: MODEL1310110014#
kinetic law: MODEL1310110014#
name: 2-aminomuconate reductase
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:not sure about name NCD
is described by: ECO:0000000

metaM elaid e
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
is: HMDB00573
name: elaidate
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:30825
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_58352426_a317_462f_a654_403cd01a2e06
type: Species
initial amount: NaN
is: SBO:0000252
name: AGL
boundary condition: true
initial concentration: NaN
is encoded by: hsa:178
has only substance units: false
constant: false

metaR MMSAD1m
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.2.1.27
reversible: false
name: methylmalonate-semialdehyde dehydrogenase
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
product: MODEL1310110014#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_7d302137_804d_4c38_a680_5754ce4a2b54
is: SBO:0000252
is: Q99944
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:80864
name: EGFL8
type: Species

metaR 3MOBte
name: Transport of 3-methyl-2-oxobutanoate
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
product: MODEL1310110014#
is: SBO:0000185
reactant: MODEL1310110014#
fast: false
is described by: ECO:0000134
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_0bb25fbb_7d18_4db2_a8eb_d0a999a7f71a
type: Species
is encoded by: hsa:4723
constant: false
initial concentration: NaN
has only substance units: false
is: E5KNH5
is: SBO:0000252
boundary condition: true
name: NDUFV1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_metaM_acgalfuc12gal14acglcgalgluside_hs_g
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00304
notes: FORMULA: C58H102N3O31FULLRCO CHARGE: 0
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
constant: false
is: CHEBI:57847
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR DM 13 cis retn n
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: 13-cis-retinoate demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_0f3ef4e6_1350_4709_8cad_80e35fa0df8f
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: Q9BV79
name: MECR
is encoded by: hsa:51102

metaM tetdecdicoa x
has only substance units: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
is: HMDB02288
name: 5,8-tetradecadienoylcoa
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_d04355a8_fe12_4fb9_ad7f_ecdfe1c1f1d4
is encoded by: hsa:4514
has part: Q96KJ9
has part: H0UI06
has part: P24311
is encoded by: hsa:1340
has part: P12074
is encoded by: hsa:1337
has part: Q7GXZ8
is encoded by: hsa:1350
is encoded by: hsa:1347
is encoded by: hsa:9167
has part: Q7GXY8
has part: Q6YFQ2
is encoded by: hsa:170712
is encoded by: hsa:4513
is encoded by: hsa:341947
is encoded by: hsa:4512
has part: P00414
is encoded by: hsa:9377
is encoded by: hsa:1327
has part: P20674
has part: Q7Z4L0
is encoded by: hsa:84701
has part: P09669
is encoded by: hsa:1349
is: SBO:0000297
has part: P13073
has part: Q6FGA0
is encoded by: hsa:1346
has part: Q8TF08
initial concentration: NaN
initial amount: NaN
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is encoded by: hsa:1351
is encoded by: hsa:1339
boundary condition: true
has part: P15954
has part: Q53YB7
constant: false
has part: Q53XN1
has part: P14854
is encoded by: hsa:1345
has part: P24310
has part: Q02221
is encoded by: hsa:1329
type: Species
is encoded by: hsa:125965
has only substance units: false

metaR r0129
reversible: true
is: SBO:0000176
is described by: ECO:0000000
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.40
product: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
fast: false
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#

metaR LEULEUPEPT1tc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR P5CDm
is: SBO:0000176
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
fast: false
product: MODEL1310110014#
type: Reaction
reversible: false
is described by: ECO:0000269
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.5.1.12

http://identifiers.org/biomodels.db/MODEL1310110014#_a2da7338_4ac8_49c3_9694_4663cd382f1c
is encoded by: hsa:4728
name: NDUFS8
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is: O00217
boundary condition: true

metaR EX tettet6 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosatetraenoic acid n-6 exchange
type: Reaction

metaM ksii core2 deg6 l
name: keratan sulfate II (core 2-linked), degradation product 6
constant: false
is: HMDB00143
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:12936
boundary condition: false
notes: FORMULA: C44H72N4O33SX CHARGE: -1
initial concentration: 1.0

metaR S6T4g
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
is: SBO:0000176
modifier: MODEL1310110014#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_6c4f7399_00ee_4aa0_8ff0_7f0d2eebee8e
name: HMGCS2
boundary condition: true
is: P54868
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3158
is: SBO:0000252
constant: false
initial amount: NaN

metaM hs deg18 l
constant: false
is: SBO:0000247
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
name: heparan sulfate, degradation product 18
initial amount: NaN
initial concentration: 1.0
is: HMDB01352
has only substance units: false
is: CHEBI:17180
boundary condition: false
type: Species

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaR EX dchac LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for deoxycholic acid
type: Reaction

metaR LALDO2x
is: SBO:0000176
kinetic law: MODEL1310110014#
is described by: ECO:0000269
name: D-Lactaldehyde:NAD+ 1-oxidoreductase
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF
modifier: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#
fast: false

metaR HDCACBP
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR CSBPASEly
is: SBO:0000176
kinetic law: MODEL1310110014#
type: Reaction
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
fast: false
reactant: MODEL1310110014#
product: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
is described by: ECO:0000000

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaM ksi deg3 l
type: Species
boundary condition: false
is: CHEBI:30825
name: keratan sulfate I, degradation product 3
initial amount: NaN
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00573

metaM Rtotal e
type: Species
is: CHEBI:3554
notes: FORMULA: CO2FULLR CHARGE: -1
constant: false
initial concentration: 1.0
is: HMDB00244
boundary condition: false
has only substance units: false
initial amount: NaN
is: C00255
is: SBO:0000247
name: R total

metaM cholcoas x
constant: false
is: CHEBI:37643
is: SBO:0000247
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1
initial concentration: 1.0
has only substance units: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoyl-CoA(S)
initial amount: NaN
boundary condition: false
type: Species

metaM HC01180 c
type: Species
is: CHEBI:58694
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
name: D-tagatofuranose 1,6-bisphosphate(4-)
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-4-3(1-16-19(10,11)12)18-6(9,5(4)8)2-17-20(13,14)15/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C03785
is: SBO:0000247
boundary condition: false

metaR FAOXC16DCr
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

metaR C181CRNt
reversible: false
reactant: MODEL1310110014#
is: SBO:0000185
is described by: ECO:0000000
name: C181 transport into the mitochondria
fast: false
type: Reaction
kinetic law: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110014#

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

metaM pail hs c
initial amount: NaN
has only substance units: false
type: Species
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: CHEBI:57880
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
boundary condition: false

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaM mi134p c
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
is: CHEBI:58414
is: HMDB01143
type: Species
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR G14T8g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

http://identifiers.org/biomodels.db/MODEL1310110014#_e90b8369_57e4_4a7a_89a7_effbb00d47f0
type: Species
has only substance units: false
constant: false
initial concentration: NaN
name: SLC22A5
is: O76082
is encoded by: hsa:6584
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM acglcgalgbside hs g
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0
is: SBO:0000247
has only substance units: false
name: GlcNAc-Gal globoside
is: CHEBI:26174
constant: false

metaR r0051
modifier: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
reactant: MODEL1310110014#
fast: false
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.5
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110014#
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7

metaM gly m
is: CHEBI:15428
initial amount: NaN
initial concentration: 1.0
is: HMDB00123
type: Species
boundary condition: false
name: Glycine
is: C00037
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037

http://identifiers.org/biomodels.db/MODEL1310110014#_47ee003f_c1be_47ae_ae4c_56cd7faa62df
boundary condition: true
is: SBO:0000252
name: SLC25A1
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:6576
initial amount: NaN
has only substance units: false
is: D9HTE9

metaM dhf m
is: CHEBI:57451
constant: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB01056
has only substance units: false
initial amount: NaN
name: dihydrofolate(2-)
boundary condition: false

metaR ETFQO
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
reversible: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
fast: false
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
reactant: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.5.5.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_7faec380_e3aa_4d8a_9aae_aca8cff47523
is: E9PD84
initial concentration: NaN
is: SBO:0000252
name: PCYT1B
constant: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:9468
has only substance units: false

metaM citr L c
boundary condition: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
name: L-citrulline
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00904
type: Species
initial amount: NaN
is: CHEBI:16349

metaM Rtotal c
is: SBO:0000247
notes: FORMULA: CO2FULLR CHARGE: -1
type: Species
is: CHEBI:16189
initial concentration: 1.0
constant: false
is: HMDB01448
has only substance units: false
boundary condition: false
name: R total
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_752736f4_e29c_4e04_9daf_8371eb2aacb4
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: MAT2B
has only substance units: false
initial amount: NaN
is encoded by: hsa:27430
constant: false
type: Species

metaM cholcoads x
is: CHEBI:27505
is: SBO:0000247
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
constant: false
is: HMDB06889
initial concentration: 1.0
boundary condition: false
type: Species
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
has only substance units: false
initial amount: NaN

metaM sucsal m
initial amount: NaN
name: Succinic semialdehyde
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
initial concentration: 1.0
is: SBO:0000247
is: HMDB01259
has only substance units: false
boundary condition: false
is: CHEBI:57706
constant: false

metaR SEBCOAPET
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

metaR r1964
name: Y+LAT2 Utilized transport
fast: false
reversible: false
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110014#
type: Reaction

metaR C4CRNe
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of butyryl carnitine into the extra cellular space
type: Reaction

metaM h e
is: CHEBI:24636
has only substance units: false
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/3380
notes: FORMULA: H CHARGE: 1 INCHI: "
initial amount: NaN
is: C00080
initial concentration: 1.0
name: proton
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_ebf40080_d92e_4db5_bdb5_0f95386464be
boundary condition: true
is: Q53YE7
name: MAOA
is encoded by: hsa:4128
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM dgchol x
initial concentration: 1.0
is: HMDB00637
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
boundary condition: false
is: CHEBI:36252
type: Species
name: glycochenodeoxycholate
constant: false

metaM c12dc c
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: dodecanedioyl carnitine
notes: FORMULA: C19H34NO6 CHARGE: -1
constant: false
has only substance units: false
is: HMDB00623
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_5430999a_03db_4355_acd5_5750db6ad765
constant: false
initial amount: NaN
is: P04746
name: AMY2A
initial concentration: NaN
is encoded by: hsa:279
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR H2Otn
fast: false
reversible: true
product: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
name: H2O transport, nuclear
reactant: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR UDPGLCAter
product: MODEL1310110014#
reversible: true
modifier: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
fast: false
is described by: ECO:0000269
is: SBO:0000185
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD

metaR ATP1ter
is: SBO:0000185
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110014#
name: ADP/ATP transporter, endoplasmic reticulum
product: MODEL1310110014#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false

metaR OCDCEAtr
kinetic law: MODEL1310110014#
fast: false
reversible: true
name: fatty acid transport via diffusion
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110014#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaR C160CPT2
name: C160 transport into the mitochondria
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
fast: false
is described by: ECO:0000269
product: MODEL1310110014#
is: SBO:0000176
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: false

metaR PROt4 2 r
is described by: ECO:0000006
modifier: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
fast: false
name: Proline transport (sodium symport) (2:1)
is: SBO:0000185
reversible: true

metaR GLCURter
kinetic law: MODEL1310110014#
name: glucuronate endoplasmic reticular transport
is: SBO:0000185
reactant: MODEL1310110014#
reversible: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false

metaR NRPPHRSULT
is version of: http://identifiers.org/ec-code/2.8.2.1
kinetic law: MODEL1310110014#
product: MODEL1310110014#
name: Norepinephrine Sulfotransferase
type: Reaction
is: SBO:0000176
reversible: false
reactant: MODEL1310110014#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
fast: false
modifier: MODEL1310110014#

metaR UMPK
product: MODEL1310110014#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
name: UMP kinase
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110014#

metaR FERO
is: SBO:0000176
kinetic law: MODEL1310110014#
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
is described by: ECO:0000134
product: MODEL1310110014#
name: ferroxidase
modifier: MODEL1310110014#
reactant: MODEL1310110014#

metaM gal14acglcgalgluside hs g
name: Lactoneotetraosylceramide
is: CHEBI:17103
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
type: Species
constant: false

metaM 34dhmald m
is: http://identifiers.org/pubchem.compound/7903
initial amount: NaN
constant: false
is: HMDB06242
name: 3,4-Dihydroxymandelaldehyde
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: C05577

http://identifiers.org/biomodels.db/MODEL1310110014#_a78ddb17_3601_417e_8840_ebc4a36ec40f
name: _AI631997_1_m
is encoded by: hsa:AI631997
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_08e95c4c_d69c_4928_a7f5_d5bc6ad5e4dc
type: Species
is: P43353
constant: false
name: ALDH3B1
is encoded by: hsa:221
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN

metaR H2Otm
reactant: MODEL1310110014#
name: H2O transport, mitochondrial
is: SBO:0000185
modifier: MODEL1310110014#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110014#
product: MODEL1310110014#

metaM stcrn c
constant: false
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
name: stearoylcarnitine
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00848
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_4abb9c04_d081_403a_9222_630c82394864
name: PIK3C2G
has only substance units: false
is: O75747
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5288
initial amount: NaN
constant: false
type: Species

metaM dag hs e
is: CHEBI:18035
boundary condition: false
is: SBO:0000247
type: Species
name: diglyceride
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0

metaR RE2973N
is version of: http://identifiers.org/ec-code/2.7.1.154
reversible: true
reactant: MODEL1310110014#
product: MODEL1310110014#
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
fast: false
name: RE2973
notes: GENE_ASSOCIATION: (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:

metaM h c
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
is: C00080
name: proton
is: SBO:0000247
is: CHEBI:24636
constant: false
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: "
boundary condition: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_36510f39_1626_42cf_bce8_1d3ac0d10204
has only substance units: false
name: HSD3B1
is encoded by: hsa:3283
boundary condition: true
is: P14060
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252

metaR r0055
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110014#
is: SBO:0000176
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
type: Reaction
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.2.7
reactant: MODEL1310110014#
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
is version of: http://identifiers.org/ec-code/2.4.2.8
fast: false
modifier: MODEL1310110014#

metaR TDPm
is: SBO:0000176
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 2 AUTHORS: PMID:9755848 NOTES:_01-25-05 IT
type: Reaction
reversible: false
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
is described by: ECO:0000000
name: thiamin pyrophosphatase, mitochondrial

metaR C160CPT1
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.21
name: production of Palmitoylcarnitine
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: false
is: SBO:0000176
modifier: MODEL1310110014#
type: Reaction

metaM xoltriol m
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB01457
boundary condition: false
is: CHEBI:16496
constant: false
has only substance units: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol

metaM dolmanp L r
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15809
name: Dolichyl phosphate D-mannose, human liver homolog
has only substance units: false
type: Species
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1

metaR DNDPt38m
reactant: MODEL1310110014#
reversible: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
name: dUTP transport via dUDP antiport
product: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
modifier: MODEL1310110014#

metaM phytcoa x
initial amount: NaN
constant: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
is: SBO:0000247
is: CHEBI:57391
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB01359
name: phytanoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110014#_b27769a1_217f_45e2_9188_bd4f3f98b4b8
constant: false
has only substance units: false
name: SLC8A3
is: SBO:0000252
type: Species
boundary condition: true
is: B3KU59
is encoded by: hsa:6547
initial concentration: NaN
initial amount: NaN

metaR NH4t3r
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110014#
name: ammonia transport via proton antiport
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
modifier: MODEL1310110014#
product: MODEL1310110014#
fast: false
reactant: MODEL1310110014#
is described by: ECO:0000269
type: Reaction

metaR r1961
reactant: MODEL1310110014#
modifier: MODEL1310110014#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000000
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_dd9fefa2_23c2_4f54_a321_c8f2b41853e8
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:341947
type: Species
name: COX8C
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q7Z4L0
constant: false

metaM 1p3h5c m
has only substance units: false
is: HMDB01369
boundary condition: false
is: CHEBI:6151
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
type: Species
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_7fd0d733_f769_4f18_bd44_080fee520833
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: P00441
is encoded by: hsa:6647
name: SOD1
constant: false
boundary condition: true
type: Species
has only substance units: false

metaR PRO1xm
product: MODEL1310110014#
fast: false
reversible: false
is described by: ECO:0000254
modifier: MODEL1310110014#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.99.8
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: proline oxidase (NAD), mitochondrial
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD

metaM oagd3 hs g
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
name: 9-O-Acetylated GD3
is: SBO:0000247
is: CHEBI:17315
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
is: HMDB01514
is: C00329
boundary condition: false
initial amount: NaN

metaR EX ksii core4 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 4-linked) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_a24e673f_52b1_4275_ad18_87f28c2cdbe1
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: GSTM1
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2944
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_33c04eb5_304e_4354_8237_b930aa28b24b
has only substance units: false
name: BTD
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:686
initial amount: NaN
initial concentration: NaN
is: P43251
type: Species

metaM 3octdectecoa x
constant: false
is: http://identifiers.org/pubchem.compound/5280355
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
boundary condition: false
type: Species
is: SBO:0000247
name: 3,6,9,12-octadecatetraenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110014#_74becd4a_20f3_469a_810a_e344be24874b
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q9NUB1
type: Species
is encoded by: hsa:84532
has only substance units: false
name: ACSS1
constant: false
is: SBO:0000252

metaR ALADGLYexR
kinetic law: MODEL1310110014#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110014#
name: D-alanine/glycine reversible exchange
modifier: MODEL1310110014#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110014#_74830368_25de_4363_8e58_26601e692928
has only substance units: false
name: ACAA1
initial amount: NaN
is encoded by: hsa:30
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is: Q96CA6

metaR MDH
reactant: MODEL1310110014#
name: malate dehydrogenase
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.37
reversible: true
modifier: MODEL1310110014#
is: SBO:0000176
product: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (130752.1) or (4190.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:Biochemical
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110014#_a66107b1_5553_40d0_8946_45f32befc001
type: Species
initial concentration: NaN
is encoded by: hsa:622
is: SBO:0000252
name: BDH1
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true

metaM lpam m
type: Species
is: CHEBI:17460
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: lipoamide
is: HMDB00962
constant: false
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
is: SBO:0000247

metaM 3ttetddcoa c
constant: false
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB02014
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
name: 3-hydroxy trans5,8tetradecadienoyl coa
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_7888a55b_80fe_4a29_8f63_62e3a11d2a51
type: Species
constant: false
initial amount: NaN
is: Q9H553
is encoded by: hsa:85365
has only substance units: false
is: SBO:0000252
name: ALG2
boundary condition: true
initial concentration: NaN

metaR CO2ter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: CO2 endoplasmic reticular transport via diffusion
fast: false

metaR THRGLYexR
is: SBO:0000185
fast: false
product: MODEL1310110014#
reversible: true
is described by: ECO:0000304
name: L-threonine/glycine reversible exchange
type: Reaction
modifier: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_07646d7c_32fb_4f2a_bdc8_6bb2c370b01e
name: _N63787_1_c
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:N63787

metaR NAHCO3 HCLt
is described by: ECO:0000269
name: bicarbonate transport (HCl/NaHCO3 exchange)
is: SBO:0000185
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
reactant: MODEL1310110014#
type: Reaction
reversible: true
kinetic law: MODEL1310110014#
product: MODEL1310110014#
fast: false
modifier: MODEL1310110014#

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_metaM_galacgalfuc12gal14acglcgalgluside_hs_g
type: Species
constant: false
has only substance units: false
name: (Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
initial amount: NaN
initial concentration: 1.0
is: CHEBI:26174
notes: FORMULA: C64H112N3O36FULLRCO CHARGE: 0
boundary condition: false
is: SBO:0000247

metaM hxcoa c
type: Species
name: Hexanoyl-CoA (n-C6:0CoA)
initial amount: NaN
boundary condition: false
is: HMDB13130
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C27H42N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110014#_b2f12cb7_22c2_44f0_99c5_4295da24b87d
initial concentration: NaN
is: P36269
is: SBO:0000252
is encoded by: hsa:2687
boundary condition: true
name: GGT5
type: Species
initial amount: NaN
constant: false
has only substance units: false

metaM glyc c
has only substance units: false
initial amount: NaN
name: Glycerol
initial concentration: 1.0
is: CHEBI:17754
is: HMDB00131
is: C00116
boundary condition: false
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_3478e787_5021_46da_8f61_8d1ceb80d7ca
has only substance units: false
is: Q5JT09
name: UCK1
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:83549

http://identifiers.org/biomodels.db/MODEL1310110014#_548b84da_01b0_4810_8d30_040ec3b1cdc2
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:2747
has only substance units: false
initial amount: NaN
is: P49448
name: GLUD2
constant: false

metaR RE0935E
reactant: MODEL1310110014#
type: Reaction
reversible: true
modifier: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000
fast: false
name: RE0935
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.1
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.17

metaM dgchol c
is: CHEBI:36252
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
name: glycochenodeoxycholate
is: SBO:0000247
has only substance units: false
is: HMDB00637
initial amount: NaN
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472

metaM dheas e
initial amount: NaN
is: CHEBI:57905
has only substance units: false
constant: false
is: HMDB01032
initial concentration: 1.0
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555

metaM hs deg8 l
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
name: heparan sulfate, degradation product 8
is: CHEBI:16126
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_5a2b57c4_db8f_4778_b780_b9eacf4d69c9
is: E7ET30
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:50808
is: SBO:0000252
name: AK3
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_7fbdf4e7_694c_4ae2_8941_7e63d5f5872a
constant: false
is: SBO:0000252
is: Q08499
type: Species
name: PDE4D
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5144
initial amount: NaN

metaM aacoa x
boundary condition: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: SBO:0000247
is: CHEBI:57286
initial concentration: 1.0
initial amount: NaN
is: HMDB01484
name: acetoacetyl-CoA(4-)
constant: false
has only substance units: false
type: Species

metaR r1008
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110014#
is: SBO:0000185
product: MODEL1310110014#
is described by: ECO:0000000
name: Facilitated diffusion
type: Reaction
fast: false
kinetic law: MODEL1310110014#
reversible: false

metaM 5HPET c
is: CHEBI:57450
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
is: SBO:0000247
constant: false
name: 5(S)-HPETE(1-)
is: HMDB01193
boundary condition: false
initial concentration: 1.0

metaM dag hs r
type: Species
name: diglyceride
initial amount: NaN
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
boundary condition: false
is: CHEBI:18035
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_1515f4eb_dc55_43d0_a09c_8b14c3e1fe80
boundary condition: true
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
name: VNN3:VNN2:VNN1
is: SBO:0000297
is encoded by: hsa:55350

metaM glyc e
name: Glycerol
initial amount: NaN
constant: false
is: HMDB00131
has only substance units: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: SBO:0000247
type: Species
boundary condition: false
is: C00116
is: CHEBI:17754
initial concentration: 1.0

metaM dec47dicoa m
initial amount: NaN
constant: false
is: SBO:0000247
name: 4,7-decadienoylcoa
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
type: Species

metaM h x
is: C00080
type: Species
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:24636

metaR RE1533M
is described by: ECO:0000000
modifier: MODEL1310110014#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
reversible: true
kinetic law: MODEL1310110014#
name: RE1533
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR SEBCOACROT
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_9cfbbae1_efb7_4216_bad5_1c794d609f63
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
name: OTC
constant: false
is encoded by: hsa:5009
is: P00480
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_8cd03c55_f73c_46c5_b306_4a7ab0acf8fa
boundary condition: true
name: PIK3C2A
has only substance units: false
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:5286
is: O00443
is: SBO:0000252
initial concentration: NaN

metaR FAOXC15C13m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C15-->C13)m
type: Reaction

metaR r0470
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
type: Reaction
fast: false
product: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000176
reactant: MODEL1310110014#

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_2d43b97f_6eb3_45e0_b308_92b143020ec8
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q6P1K9
constant: false
name: PANK2
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:80025

metaR TETDECE1CRNe
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tetradecenoyl carnitine into extra cellular space
type: Reaction

metaR NADHtru
name: NADH transporter, endoplasmic reticulum
product: MODEL1310110014#
type: Reaction
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
fast: false
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000185

metaR PMEVKc
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added to substrate for elemental balancing.
name: phosphomevalonate kinase, cytosol
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.4.2
type: Reaction
is described by: ECO:0000134
reversible: false

metaM ksi deg41 l
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00143
initial amount: NaN
has only substance units: false
is: CHEBI:12936
notes: FORMULA: C34H58N2O26 CHARGE: 0
name: keratan sulfate I, degradation product 41
constant: false

metaM docosahexcoa m
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: 3,7,10,13,16,19-docosahexenoylcoa
has only substance units: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892790
type: Species
constant: false

metaR FATP6t
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/6.2.1.7
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
fast: false
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
name: fatty acid electroneutral transport

metaR GCHOLAte
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#
fast: false
name: bile acid intracellular transport
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110014#_3ad7f3cc_eb76_44d3_b620_f23702a5b656
is encoded by: hsa:8818
initial concentration: NaN
is: O94777
boundary condition: true
name: DPM2
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaM dgchol e
has only substance units: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: CHEBI:36252
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00637
initial amount: NaN
name: glycochenodeoxycholate

http://identifiers.org/biomodels.db/MODEL1310110014#_8b14636a_d7a6_40a2_8b69_bb3aa2e75d83
has only substance units: false
is: SBO:0000252
is: Q9NR34
is encoded by: hsa:57134
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
constant: false
name: MAN1C1

http://identifiers.org/biomodels.db/MODEL1310110014#_2fda5a14_d51b_4bb2_b6d2_1b390999ff01
type: Species
name: ACOT1
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: E9KL42
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:641371

http://identifiers.org/biomodels.db/MODEL1310110014#_93350f08_a7e7_4b07_a96b_75c26d4275b1
is: Q6NSB3
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: AMY1A
constant: false
is encoded by: hsa:276
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_5452864c_1210_4aaf_bc72_54d09522781e
has only substance units: false
type: Species
name: A4GALT
is encoded by: hsa:53947
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is: Q9NPC4
initial concentration: NaN

metaR VACCCPT1
reversible: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
fast: false
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
modifier: MODEL1310110014#
product: MODEL1310110014#
name: carnitine O-palmitoyltransferase

metaM xyl D l
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:15936
name: aldehydo-D-xylose
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_97bfb9ca_8faf_4f5d_a6d5_10a6580d9a2b
boundary condition: true
is encoded by: hsa:8528
is: SBO:0000252
name: DDO
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: Q99489
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_b4b82c28_3126_4739_bd15_0a6963366010
is: SBO:0000252
initial amount: NaN
is: Q14916
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6568
type: Species
has only substance units: false
name: SLC17A1

metaM 10fthf7glu e
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C50H57N13O25 CHARGE: -8
initial amount: NaN
is: SBO:0000247
is: HMDB00972
has only substance units: false
name: 10-formyltetrahydrofolate-[Glu](7)
type: Species
is: CHEBI:57454

metaR FAOXC184m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

metaM ptdcacrn m
is: SBO:0000247
is: HMDB01721
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
has only substance units: false
is: CHEBI:15811
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
name: pendtadenoyl carnitine

metaM tetdecdicoa m
constant: false
is: HMDB02288
type: Species
is: SBO:0000247
name: 5,8-tetradecadienoylcoa
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C35H54N7O17P3S CHARGE: -4

metaM pail4p hs n
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
is: CHEBI:58178
constant: false
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)

http://identifiers.org/biomodels.db/MODEL1310110014#_53998c57_b6de_4fa1_88e7_d1ebe5779d49
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:54576
type: Species
name: UGT1A8
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q5DSZ6

metaR r0472
product: MODEL1310110014#
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reversible: true
reactant: MODEL1310110014#
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110014#

metaR r0698
type: Reaction
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
reactant: MODEL1310110014#
product: MODEL1310110014#
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
fast: false
modifier: MODEL1310110014#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.27
is described by: ECO:0000000

metaR BHBt
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
product: MODEL1310110014#

metaM 2hexdtricoa x
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
name: 2,7,10-hexadecatrienoylcoa
is: HMDB02288
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM c101crn e
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C17H31NO4 CHARGE: 0
is: HMDB13205
name: decenoyl carnitine
type: Species
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR P4502E1
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110014#
name: cytochrome P450 2E1
reversible: false
notes: GENE_ASSOCIATION: (1571.1) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15579107,PMID:3233219 NOTES:_4 nitrophenol 2-hydroxylation assumed to take place on outer membrane (xenobiotic metabolism) NJ
reactant: MODEL1310110014#
modifier: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110014#_a369dee5_6243_47cc_b003_fa1ce0ed6eb5
name: NDUFS5
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4725
initial concentration: NaN
boundary condition: true
type: Species
is: Q6IBA0

http://identifiers.org/biomodels.db/MODEL1310110014#_2712c875_6180_4e30_b2c4_12e028afdfa7
initial concentration: NaN
initial amount: NaN
name: SLCO2A1
is encoded by: hsa:6578
type: Species
is: SBO:0000252
has only substance units: false
is: Q92959
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_0966b532_e20a_4dc7_aca5_49e99a69ce14
has only substance units: false
name: _AI915649_1_c
is encoded by: hsa:AI915649
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false

metaM c8crn c
type: Species
initial amount: NaN
notes: FORMULA: C15H29NO4 CHARGE: 0
name: octanoyl carnitine
is: SBO:0000247
is: C02838
has only substance units: false
is: HMDB00791
constant: false
boundary condition: false
initial concentration: 1.0

metaR HDDACBP
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR R group phosphotase 1
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110014#
is: SBO:0000176
fast: false
name: R group phosphotase 1
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000000
type: Reaction
reversible: false

metaR r1746
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
product: MODEL1310110014#
name: Y+LAT2 Utilized transport
fast: false

W3 CDTF: Thu Aug 30 17:05:21 BST 2012

metaR PAIL HStn
fast: false
reactant: MODEL1310110014#
name: phosphatidylinositol nuclear transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110014#
product: MODEL1310110014#

metaM pail3p hs n
initial concentration: 1.0
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
is: CHEBI:58088
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
type: Species
is: SBO:0000247
has only substance units: false
constant: false

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_c8981de3_fbf7_4b82_8c84_42b0a3bf8e80
initial concentration: NaN
initial amount: NaN
name: AGL
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:178
constant: false
boundary condition: true

metaR CORE4GTg
reversible: false
modifier: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.102
fast: false
is: SBO:0000176
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
kinetic law: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD

metaR VALTA
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: valine transaminase
fast: false
is: SBO:0000176
modifier: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42
reversible: true
type: Reaction

metaM glyc R m
name: D-glycerate
is: CHEBI:16659
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
type: Species
is: HMDB00139
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false

metaM pchol hs m
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: Phosphatidylcholine
constant: false
is: CHEBI:16110

W3 CDTF: Thu Aug 30 17:05:21 BST 2012

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_c74c5d44_bf66_44de_b4c1_b8826c757d13
is: Q99798
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
name: ACO2
has only substance units: false
is encoded by: hsa:50

metaR VACCCPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
reversible: false
kinetic law: MODEL1310110014#
is: SBO:0000176
fast: false
name: carnitine transferase
modifier: MODEL1310110014#

metaM c101crn c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB13205
type: Species
notes: FORMULA: C17H31NO4 CHARGE: 0
constant: false
is: SBO:0000247
has only substance units: false
name: decenoyl carnitine

metaR H7ET2er
reactant: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.8.1
modifier: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
product: MODEL1310110014#
name: H7 phosphoethanolaminyl transferase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (5281.1) and (54872.1) or (5281.2) and (54872.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15632136 NOTES:NCD
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110014#_1e97c7ef_49bc_4450_a49a_a3cf61fd9ffe
is: Q4KWH8
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: PLCH1
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:23007
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_60682e4b_acf6_4620_bf9e_0f290b109ff2
is: P30838
type: Species
initial concentration: NaN
constant: false
name: ALDH3A1
initial amount: NaN
is encoded by: hsa:218
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR FUT910g
reversible: false
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
fast: false
name: Alpha-(1,3)-fucosyltransferase
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.152
is described by: ECO:0000269
product: MODEL1310110014#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110014#

metaM c8crn e
notes: FORMULA: C15H29NO4 CHARGE: 0
is: SBO:0000247
is: C02838
name: octanoyl carnitine
is: HMDB00791
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_metaM_fucgalacgalfuc12gal14acglcgalgluside_hs_g
notes: FORMULA: C70H122N3O40FULLRCO CHARGE: 0
is: SBO:0000247
constant: false
name: Type IIIH glycolipid
has only substance units: false
type: Species
is: HMDB00304
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57847

metaR CATp
notes: GENE_ASSOCIATION: (847.1) SUBSYSTEM: Miscellaneous EC Number: 1.11.1.6 Confidence Level: 0 AUTHORS: PMID:18634816,PMID:18634817 NOTES:NCD
kinetic law: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000134
fast: false
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.11.1.6
product: MODEL1310110014#
name: catalase A, peroxisomal
type: Reaction
modifier: MODEL1310110014#
reversible: false

metaR AG13T10g
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110014#
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
modifier: MODEL1310110014#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_36b1b83e_bd26_4321_9624_479698bc51dc
name: ENTPD3
boundary condition: true
initial concentration: NaN
is encoded by: hsa:956
constant: false
is: SBO:0000252
is: O75355
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_e56b643a_2754_41d4_8c19_b4db0fe6b9f1
is: P31350
name: RRM2
type: Species
constant: false
is encoded by: hsa:6241
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_722efba1_b6a0_4f21_ade2_870faa3c39d0
constant: false
type: Species
is encoded by: hsa:4705
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: O95299
initial amount: NaN
boundary condition: true
name: NDUFA10

metaM 2mb2coa m
initial concentration: 1.0
name: 2-methylcrotonoyl-CoA(4-)
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
is: SBO:0000247
is: CHEBI:57337
is: HMDB02054
has only substance units: false
type: Species

metaR r1666
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
fast: false
modifier: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true
product: MODEL1310110014#

metaR SPODM
is described by: ECO:0000269
product: MODEL1310110014#
modifier: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
reversible: false
name: superoxide dismutase
is: SBO:0000176
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.15.1.1
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
type: Reaction

metaR CRNt
reversible: true
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
kinetic law: MODEL1310110014#
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
fast: false
name: L-carnitine reversible transport
modifier: MODEL1310110014#

metaR CBR2
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.189
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: Carbonyl reductase [NADPH] 1
product: MODEL1310110014#
type: Reaction
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ
is: SBO:0000176

metaR NACHEX2ly
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
reactant: MODEL1310110014#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
reversible: false
is: SBO:0000176
modifier: MODEL1310110014#
type: Reaction
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_7f0fb615_44d2_4590_8d8a_227602a1edc9
has only substance units: false
is: Q9Y259
initial amount: NaN
is encoded by: hsa:1120
name: CHKB
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species

metaR MM6B2g
reactant: MODEL1310110014#
is described by: ECO:0000000
product: MODEL1310110014#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
modifier: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
reversible: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is version of: http://identifiers.org/ec-code/3.2.1.113
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_da1b91f6_0ffe_4efc_96f4_59205b886d2b
initial concentration: NaN
boundary condition: true
type: Species
name: CA7
constant: false
has only substance units: false
is: P43166
is: SBO:0000252
is encoded by: hsa:766
initial amount: NaN

metaR FAOXC2031836m
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110014#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:3 -> c18:3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of fatty acid
is: SBO:0000176
reactant: MODEL1310110014#

metaM cspg a l
type: Species
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
initial amount: NaN
has only substance units: false
is: HMDB02183
initial concentration: 1.0
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
boundary condition: false
constant: false
is: CHEBI:36005
is: SBO:0000247

metaR FAOXC141C121x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C14:1-->C12:1)x
type: Reaction

metaM h r
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/3380
type: Species
is: CHEBI:24636
is: C00080
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
constant: false
boundary condition: false
name: proton

metaR DNDPt8m
name: dADP transport via dUDP antiport
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
is described by: ECO:0000269
reversible: false
fast: false
is: SBO:0000185

metaM pheacgln e
type: Species
initial concentration: 1.0
is: CHEBI:58310
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
initial amount: NaN
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
has only substance units: false
is: HMDB06344

metaM hs deg19 l
is: CHEBI:17180
initial amount: NaN
boundary condition: false
is: HMDB01352
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
name: heparan sulfate, degradation product 19
initial concentration: 1.0
type: Species

metaR FAOXC226C225m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_7f48e544_bd75_4892_97bf_8f7c14f6060a
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:HG2846-HT2983
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
name: _HG2846_HT2983_1_c

metaM dec47dicoa x
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
constant: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
name: 4,7-decadienoylcoa

metaM 34dhmald c
initial amount: NaN
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: HMDB06242
is: http://identifiers.org/pubchem.compound/7903
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: 3,4-Dihydroxymandelaldehyde
is: C05577
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_852db51a_24b2_4e65_95b0_55df3303b0dc
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: RDH13
initial concentration: NaN
boundary condition: true
is: B3KVA3
constant: false
is encoded by: hsa:112724

metaR MM7B2g
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.113
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
kinetic law: MODEL1310110014#
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110014#
modifier: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
product: MODEL1310110014#

metaR r1667
is: SBO:0000185
fast: false
product: MODEL1310110014#
type: Reaction
reversible: true
name: Y+LAT2 Utilized transport
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_dcc5f13d_f510_4a2b_a01b_5d3e7b77b0bd
is: Q99999
constant: false
name: GAL3ST1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:9514

http://identifiers.org/biomodels.db/MODEL1310110014#_7ea9ba66_62d8_4e38_acec_2f7f851ca42c
is encoded by: hsa:AA576959
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
name: _AA576959_1_c
initial amount: NaN
has only substance units: false

metaR CARVEOLte
name: xenobiotic transport
type: Reaction
product: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110014#
reversible: true
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, xenobiotic transport (original and metabolized) NJ

http://identifiers.org/biomodels.db/MODEL1310110014#_2df68218_9a52_40a6_947e_1b054df2f72f
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
name: B3GALT5
has only substance units: false
is encoded by: hsa:10317

http://identifiers.org/biomodels.db/MODEL1310110014#_5b4c6912_0d97_496b_a694_f004e3861630
initial amount: NaN
is encoded by: hsa:54965
is encoded by: hsa:93183
initial concentration: NaN
constant: false
has part: Q8TBF5
boundary condition: true
type: Species
has part: Q9H3S5
name: PIGX:PIGM
has only substance units: false
is: SBO:0000297

metaR CBASPte
is described by: ECO:0000134
reactant: MODEL1310110014#
fast: false
reversible: true
type: Reaction
product: MODEL1310110014#
name: Transport of N-carbamoyl-L-aspartate
kinetic law: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM glyc m
is: CHEBI:17754
boundary condition: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
type: Species
name: Glycerol
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: C00116
is: HMDB00131

http://identifiers.org/biomodels.db/MODEL1310110014#_b7c3593f_f06c_48f4_9acc_17467bf623ed
is: E7EQF2
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:54677
type: Species
name: CROT
initial amount: NaN
constant: false

metaR r1668
kinetic law: MODEL1310110014#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Y+LAT2 Utilized transport
fast: false
product: MODEL1310110014#
is described by: ECO:0000000
modifier: MODEL1310110014#
reactant: MODEL1310110014#

metaR FAOXC163C164x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_3770b060_4067_4e7e_bab6_3839633c86c3
is encoded by: hsa:51703
constant: false
name: ACSL5
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is: Q9ULC5
initial amount: NaN
boundary condition: true

metaM phytcoa c
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
initial amount: NaN
is: HMDB01359
name: phytanoyl-CoA(4-)
is: SBO:0000247
is: CHEBI:57391
constant: false

metaM ksi pre12 g
name: keratan sulfate I biosynthesis, precursor 12
is: CHEBI:58053
is: HMDB00175
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
is: C00130
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_8a74b40b_70c0_4889_ad19_256dcc85fc29
type: Species
boundary condition: true
is encoded by: hsa:8703
name: B4GALT3
is: SBO:0000252
constant: false
is: A8K5Z0
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR DHEASt
reactant: MODEL1310110014#
product: MODEL1310110014#
name: dehydroepiandrosterone sulfate transport via bicarbonate countertransport
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000185
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (11309.1) or (6579.1) or (28234.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
fast: false
type: Reaction

metaM gam c
is: HMDB01514
is: CHEBI:17315
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
name: D-Glucosamine
is: C00329
constant: false
initial concentration: 1.0
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329

metaM adrncrn m
is: HMDB00062
name: Adrenyl carnitine
constant: false
initial concentration: 1.0
initial amount: NaN
is: C00318
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:16347
is: SBO:0000247
notes: FORMULA: C29H49NO4 CHARGE: 0

metaM 34dhphe c
constant: false
is: HMDB00181
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15765
name: L-dopa
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110014#_e74ab982_50df_4acf_ad6f_d75f978b027d
name: _AF080579_1_c
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:AF080579
initial concentration: NaN
type: Species
initial amount: NaN

metaM dlnlcgcrn m
constant: false
is: SBO:0000247
initial amount: NaN
name: dihomo-gamma-linolenyl carnitine
is: CHEBI:16004
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: HMDB01311

metaR r1443
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: EC:1.3.3.6
fast: false
product: MODEL1310110014#
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:

metaR PI34P5K
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
reversible: false
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
product: MODEL1310110014#
fast: false
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.1.68

metaR CREATt4 2 r
type: Reaction
name: Creatine transport (sodium symport) (2:1)
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110014#
reversible: true
reactant: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110014#

metaR FAOXC163C164Gm
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

metaR r1669
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_1aa65989_6611_4ac2_b8be_57405d670a5b
has only substance units: false
name: ALPPL2
is encoded by: hsa:251
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is: P10696
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_c9b7f6bd_8ea9_4fef_8fe2_06dbf90e12a9
type: Species
is: Q00266
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: MAT1A
is encoded by: hsa:4143

http://identifiers.org/biomodels.db/MODEL1310110014#_021a5431_d062_487b_8107_88f1a474c195
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2588
name: GALNS
is: P34059
constant: false
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false

metaR r0365
modifier: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.72
kinetic law: MODEL1310110014#
reversible: false
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
reactant: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110014#_0d1283d0_4797_4b62_8e36_33704a2c51eb
name: IMPDH1
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:3614
is: B3KRZ3

metaR r1662
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110014#
product: MODEL1310110014#
fast: false
type: Reaction
kinetic law: MODEL1310110014#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaM glygn5 e
is: HMDB06372
initial amount: NaN
is: CHEBI:33871
notes: FORMULA: C12H21O11X CHARGE: 0
name: glycogen, structure 5 (glycogenin-2[1,4-Glc])
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_metaM_fucgalacgalfucgalacglcgal14acglcgalgluside_hs_g
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
constant: false
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)2 (Cer)1
has only substance units: false
initial concentration: 1.0
is: CHEBI:61648

metaM CE5126 x
boundary condition: false
name: (2R)-pristanoyl-CoA
type: Species
constant: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5126
has only substance units: false
is: CHEBI:12947
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM glyc R c
boundary condition: false
name: D-glycerate
constant: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: CHEBI:16659
is: SBO:0000247
is: HMDB00139
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN

metaR NH4tp
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110014#
product: MODEL1310110014#
name: ammonia peroxisomal transport
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110014#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_57afa828_f656_41e1_a63b_d53e7c6577ae
is encoded by: hsa:7358
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: UGDH
is: O60701
has only substance units: false
is: SBO:0000252

metaM citr L m
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
name: L-citrulline
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:16349
type: Species
is: HMDB00904
initial amount: NaN

metaR 4PYRDX
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT Reaction correct??? (active transport)
name: 4-Pyridoxal secretion
product: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
is: SBO:0000185
reactant: MODEL1310110014#
is described by: ECO:0000000
type: Reaction

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

metaR ADEt
modifier: MODEL1310110014#
reversible: true
reactant: MODEL1310110014#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
name: adenine reversible transport, cytosol
product: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD

metaR FACOAL226
product: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110014#
name: fatty-acid--CoA ligase
is: SBO:0000176
modifier: MODEL1310110014#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110014#

metaM 34dhphe e
name: L-dopa
is: CHEBI:15765
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
is: HMDB00181
boundary condition: false

metaR r0360
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110014#
fast: false
product: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.16
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:

metaM ksi pre23 g
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 23
constant: false
has only substance units: false
is: CHEBI:28067
initial amount: NaN
type: Species
notes: FORMULA: C185H296N13O153S7X CHARGE: -8

http://identifiers.org/biomodels.db/MODEL1310110014#_e2040d2b_79d4_4d9e_8e18_630f44c7b637
is: Q9HCC0
type: Species
boundary condition: true
name: MCCC2
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:64087
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_58091863_98ac_455e_bc7e_eb5d4e17df10
constant: false
name: QDPR
is: P09417
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5860
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_ed486d2d_bdc6_4222_a59e_a2fcab9d49c3
is encoded by: hsa:1375
is: Q92523
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: CPT1B
type: Species
initial amount: NaN

metaM m6masnB2 g
constant: false
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false
is: CHEBI:30825
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00573
notes: FORMULA: C58H97N2O45X CHARGE: 0
is: SBO:0000247

metaR DOPABMO
product: MODEL1310110014#
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (26002.1) or (1621.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.17.1 Confidence Level: 4 AUTHORS: NOTES:SAB
name: dopamine beta-monooxygenase
reversible: false
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.17.1
reactant: MODEL1310110014#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110014#_fd9fd914_9d81_4f56_98d2_33b9af549d65
is: P21549
constant: false
is encoded by: hsa:189
initial amount: NaN
has only substance units: false
type: Species
name: AGXT
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM gam e
constant: false
initial concentration: 1.0
is: HMDB01514
has only substance units: false
boundary condition: false
initial amount: NaN
name: D-Glucosamine
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
type: Species
is: CHEBI:17315
is: C00329
is: SBO:0000247

metaM 4hpro LT m
has only substance units: false
is: HMDB00725
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
name: trans-4-hydroxy-L-proline
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:18095
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_a176d686_31f6_413c_914c_e5b5b4868aea
boundary condition: true
is encoded by: hsa:4967
is: Q02218
is: SBO:0000252
initial concentration: NaN
name: OGDH
constant: false
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_74b785ed_2ef6_499a_a032_b27cd8598329
is: O43426
initial concentration: NaN
name: SYNJ1
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:8867
boundary condition: true
type: Species

metaR RE2974C
type: Reaction
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.149
fast: false
product: MODEL1310110014#
name: RE2974
is version of: http://identifiers.org/ec-code/2.7.1.68
is described by: ECO:0000000
modifier: MODEL1310110014#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_8e58b313_0f05_406d_96e0_6d9cb0e15151
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q9ULC5
is: SBO:0000252
initial amount: NaN
name: ACSL5
type: Species
constant: false
is encoded by: hsa:51703

metaM dmhptcoa m
notes: FORMULA: C30H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C30H52N7O17P3S/c1-17(2)7-6-8-18(3)29(42)58-12-11-32-20(38)9-10-33-27(41)24(40)30(4,5)14-51-57(48,49)54-56(46,47)50-13-19-23(53-55(43,44)45)22(39)28(52-19)37-16-36-21-25(31)34-15-35-26(21)37/h15-19,22-24,28,39-40H,6-14H2,1-5H3,(H,32,38)(H,33,41)(H,46,47)(H,48,49)(H2,31,34,35)(H2,43,44,45)/p-4/t18-,19+,22-,23-,24?,28+/m0/s1
is: HMDB06258
boundary condition: false
type: Species
constant: false
has only substance units: false
is: SBO:0000247
name: 2,6 dimethylheptanoyl-CoA
initial amount: NaN
initial concentration: 1.0

metaR HDCAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
product: MODEL1310110014#
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: true

metaM ptdcacrn c
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: HMDB01721
name: pendtadenoyl carnitine
initial amount: NaN
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
is: CHEBI:15811
type: Species
is: SBO:0000247

metaR AHC
type: Reaction
reactant: MODEL1310110014#
product: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110014#
reversible: true
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.3.1.1
name: adenosylhomocysteinase

metaM 2hexdtricoa m
type: Species
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
name: 2,7,10-hexadecatrienoylcoa
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB02288

metaR r1664
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: true
product: MODEL1310110014#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_05c1539a_407f_4465_98e7_834cb00099a0
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: O94925
is encoded by: hsa:2744
name: GLS

metaR NH4tn
name: ammonia nuclear transport
fast: false
product: MODEL1310110014#
is: SBO:0000185
reactant: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reversible: true
is described by: ECO:0000000

metaR r1856
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110014#
is described by: ECO:0000000
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
name: Y+LAT2 Utilized transport
product: MODEL1310110014#
fast: false
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_02388324_dd25_48f8_a9d5_9fad3306f763
name: ALDH3B2
is: P48448
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:222
initial concentration: NaN

metaR FACOAL224
is described by: ECO:0000000
reactant: MODEL1310110014#
modifier: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
fast: false
name: fatty-acid--CoA ligase

metaR BCRNe
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy butyryl carnitine into extra cellular space
type: Reaction

metaR FAOXC184x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:4)x
type: Reaction

metaR BHBtm
kinetic law: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
product: MODEL1310110014#
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
is: SBO:0000185
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_541284f0_c9e9_4a9e_a2c5_959e6ea8e7c4
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:6448
is: SBO:0000252
has only substance units: false
is: P51688
boundary condition: true
name: SGSH
type: Species

metaR r1665
name: Y+LAT2 Utilized transport
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000000

metaM dheas c
is: CHEBI:57905
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: HMDB01032
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
initial amount: NaN
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
is: SBO:0000247

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaR S6TASE11ly
fast: false
reversible: true
product: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#

metaR r0361
reversible: false
modifier: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
is: SBO:0000176
kinetic law: MODEL1310110014#
type: Reaction
fast: false
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.1.3.3
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
notes: GENE_ASSOCIATION: (5009.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:

metaR r0587
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.2.1.5

http://identifiers.org/biomodels.db/MODEL1310110014#_fcbf6035_e02b_4dd3_a49b_8a266c9a3f84
name: GSTM1
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is: P09488
is encoded by: hsa:2944
boundary condition: true

metaR AKR1C1
reversible: false
reactant: MODEL1310110014#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (1645.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.1.20 Confidence Level: 4 AUTHORS: PMID:8486699 NOTES:NJ
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.20
name: aldo-keto reductase family 1, member C1 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)

metaM r1p c
has only substance units: false
is: HMDB01489
is: CHEBI:57720
type: Species
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
is: SBO:0000247
initial amount: NaN
constant: false
is: C00442
initial concentration: 1.0
name: alpha-D-Ribose 1-phosphate
boundary condition: false

metaR CYTK13n
fast: false
name: cytidylate kinase (dCMP,dATP),nuclear
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
is: SBO:0000176
is described by: ECO:0000269

metaR S2TASE3ly
kinetic law: MODEL1310110014#
name: iduronate-2-sulfatase, lysosomal
fast: false
is described by: ECO:0000000
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.6.13
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
reversible: false
product: MODEL1310110014#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110014#_2211058a_78b4_4906_8149_2da4b25e6746
boundary condition: true
is encoded by: hsa:124637
type: Species
has only substance units: false
initial concentration: NaN
name: CYB5D1
is: SBO:0000252
constant: false
initial amount: NaN
is: Q6P9G0

metaR NDPK1m
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110014#
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
modifier: MODEL1310110014#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110014#
fast: false
reactant: MODEL1310110014#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_ce6734eb_115d_4060_9fde_ee6079d0b6d0
is encoded by: hsa:39
constant: false
boundary condition: true
initial amount: NaN
name: ACAT2
has only substance units: false
type: Species
is: Q9BWD1
initial concentration: NaN
is: SBO:0000252

metaM pchol hs e
name: Phosphatidylcholine
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16110
constant: false
is: SBO:0000247
type: Species

metaR DDECE1CRNe
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of dodecenoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_4fe4fd37_42b7_419d_92c7_314cad5cefbe
constant: false
is encoded by: hsa:54898
type: Species
name: ELOVL2
is: Q9NXB9
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_metaR_GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is: SBO:0000185
reactant: MODEL1310110014#
name: blood group intracellular transport
kinetic law: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true

metaR r2514
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false
type: Reaction
product: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110014#
is described by: ECO:0000000

metaR UGT1A6r
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
is: SBO:0000176
fast: false
modifier: MODEL1310110014#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (54575.1) or (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 4 AUTHORS: PMID:15117964,PMID:9295054 NOTES:NJ
is described by: ECO:0000269
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.17
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#

metaM 4hoxpacd c
initial concentration: 1.0
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
name: (4-hydroxyphenyl)acetaldehyde
is: CHEBI:15621
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB03767
has only substance units: false

metaM HC02024 r
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C45H76O2 CHARGE: 0 INCHI: InChI=1S/C45H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h11-12,14-15,26,35-36,38-42H,7-10,13,16-25,27-34H2,1-6H3/b12-11-,15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
constant: false
name: Cholesterol-ester-lin
initial amount: NaN
is: CHEBI:41509
has only substance units: false
type: Species

metaM HC00342 c
initial concentration: 1.0
is: CHEBI:16383
has only substance units: false
constant: false
name: cis-aconitate(3-)
is: SBO:0000247
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
type: Species
boundary condition: false
initial amount: NaN

metaR FAOXC183C163Gm
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

metaM ppi n
is: HMDB00250
is: CHEBI:33019
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0
has only substance units: false
name: diphosphate(3-)
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR ADRNt
fast: false
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reversible: true
name: fatty acid transport via diffusion
is: SBO:0000185
product: MODEL1310110014#
type: Reaction

metaM acald e
initial concentration: 1.0
is: CHEBI:15343
constant: false
is: SBO:0000247
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: HMDB00990
type: Species
initial amount: NaN
name: acetaldehyde
boundary condition: false
has only substance units: false

metaM HC00250 e
initial amount: NaN
name: hydrosulfide
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
type: Species
is: CHEBI:29919

metaM 3octdeccrn c
name: 3-hydroxyoctadecanoyl carnitine
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C25H49NO5 CHARGE: 0
is: SBO:0000247
is: HMDB13336

metaR r1563
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110014#
is: SBO:0000185
fast: false
reactant: MODEL1310110014#

metaR RE1517M
reactant: MODEL1310110014#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110014#
name: RE1517
type: Reaction
reversible: true
is: SBO:0000176
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.3.99.13

metaM gpi prot hs r
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2X CHARGE: 0
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:7896
name: {[(Prot-PE-Man),(PE)-Man],[PE]}-Man-GlcN-acylPI
boundary condition: false
is: SBO:0000247
is: C00249
type: Species
is: HMDB00220
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_070318f7_a18f_42f3_a571_68f28b99f5b9
is: Q9Y619
boundary condition: true
is encoded by: hsa:10166
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: SLC25A15

metaM ksi deg36 l
type: Species
name: keratan sulfate I, degradation product 36
is: HMDB00143
initial amount: NaN
boundary condition: false
is: CHEBI:12936
constant: false
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_27a9ea9e_4668_4632_919b_5f5976d6ecd3
name: B3GNT8
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:374907
has only substance units: false
initial amount: NaN
boundary condition: true

metaR r2369
product: MODEL1310110014#
type: Reaction
reversible: true
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
fast: false
name: Organic anion transporter 5 Utilized transport

metaR B3GNT314g
product: MODEL1310110014#
is: SBO:0000176
reactant: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
fast: false
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is described by: ECO:0000254
reversible: false

metaR NACHEX22ly
reversible: false
product: MODEL1310110014#
is described by: ECO:0000000
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal

metaR r1998
reversible: false
modifier: MODEL1310110014#
product: MODEL1310110014#
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110014#_f68a6737_e283_473f_9764_2b7f817786b4
initial concentration: NaN
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10317
boundary condition: true
name: B3GALT5

metaM msa m
is: HMDB11111
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
boundary condition: false
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:33190
name: 3-oxopropanoate

metaR r0317
is version of: http://identifiers.org/ec-code/1.8.1.4
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
kinetic law: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.10
modifier: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000176
reversible: true
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.4.4.2

http://identifiers.org/biomodels.db/MODEL1310110014#_46ee4344_70a9_4f9d_b8a8_2a2ec4a29d0a
constant: false
is encoded by: hsa:847
initial concentration: NaN
name: CAT
is: P04040
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252

metaR r0719
product: MODEL1310110014#
kinetic law: MODEL1310110014#
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reactant: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.153
fast: false
notes: GENE_ASSOCIATION: (6697.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
modifier: MODEL1310110014#
is: SBO:0000176

metaR RE2972M
type: Reaction
modifier: MODEL1310110014#
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.67
reversible: true
name: RE2972
fast: false
is: SBO:0000176
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:

metaR r1564
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110014#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110014#
reactant: MODEL1310110014#
fast: false

metaR HEX7
is version of: http://identifiers.org/ec-code/2.7.1.2
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
type: Reaction
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
name: hexokinase (D-fructose:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.1
is described by: ECO:0000304

metaR NACHEXA14ly
name: beta-N-acetylhexosaminidase A, lysosomal
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
modifier: MODEL1310110014#
reversible: false
reactant: MODEL1310110014#
product: MODEL1310110014#
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_metaR_GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEte
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110014#
name: blood group intracellular transport
product: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
kinetic law: MODEL1310110014#

metaM c51crn c
is: HMDB02366
type: Species
initial concentration: 1.0
name: tiglyl carnitine
initial amount: NaN
boundary condition: false
notes: FORMULA: C12H21NO4 CHARGE: 0
has only substance units: false
is: SBO:0000247
constant: false

metaR FAOXC181C181OHm
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C18:1OH)m
type: Reaction

metaR r2516
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
reactant: MODEL1310110014#
is: SBO:0000185
product: MODEL1310110014#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
kinetic law: MODEL1310110014#

metaM galgbside hs g
constant: false
initial concentration: 1.0
is: CHEBI:18259
is: SBO:0000247
name: galactosylgloboside
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_68825561_6581_4bc7_a5ff_0fc7977f279e
type: Species
has only substance units: false
is: P17812
name: CTPS1
is encoded by: hsa:1503
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_7aa8c232_0a37_42ed_99b3_ef66859f2a84
boundary condition: true
name: TYMS
initial concentration: NaN
has only substance units: false
is encoded by: hsa:7298
is: P04818
initial amount: NaN
is: SBO:0000252
type: Species
constant: false

metaM pchol hs c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
is: CHEBI:16110
is: SBO:0000247
type: Species
initial amount: NaN
name: Phosphatidylcholine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_064fd894_913a_48ca_be2c_a131b6fe1236
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q96KJ9
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:84701
name: COX4I2
constant: false

metaM 5oxpro c
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00267
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
name: 5-oxoprolinate
is: CHEBI:57606
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_e9d2f643_76d7_4691_8c69_a79f41a9f510
initial concentration: NaN
boundary condition: true
is: Q8N1Q1
name: CA13
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:377677
initial amount: NaN

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaR G6PDH2rer
product: MODEL1310110014#
reversible: true
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
is: SBO:0000176
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
is version of: http://identifiers.org/ec-code/1.1.1.47

metaR r2368
type: Reaction
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110014#
is described by: ECO:0000000
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_c793699e_44bd_4f73_915f_acbcb045fcd2
is encoded by: hsa:6487
type: Species
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
name: ST3GAL3
boundary condition: true
is: SBO:0000252

metaR r1999
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110014#
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
modifier: MODEL1310110014#
reversible: false

metaR r1561
reversible: true
product: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaR 5ADTSTSTERONESte
type: Reaction
name: sulfonated testosterone transport
is: SBO:0000185
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
fast: false
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000000
reversible: true

metaM HC00250 c
is: CHEBI:29919
name: hydrosulfide
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
type: Species

metaM 3octdeccrn e
type: Species
initial concentration: 1.0
name: 3-hydroxyoctadecanoyl carnitine
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB13336
boundary condition: false
notes: FORMULA: C25H49NO5 CHARGE: 0

metaM oxa c
is: HMDB02329
constant: false
name: oxalate(2-)
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:30623
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209

metaR AGTix
is: SBO:0000176
is described by: ECO:0000269
reversible: false
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (189.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:1703535,PMID:9038835,PMID:9783918 NOTES:NCD
modifier: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: alanine-glyoxylate transaminase (irreversible), (peroxisomal)
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.44

metaM Asn X Ser Thr l
is: C01342
is: CHEBI:28938
initial amount: NaN
name: protein-linked asparagine residue (N-glycosylation site)
is: SBO:0000247
is: HMDB00051
has only substance units: false
type: Species
constant: false
notes: FORMULA: XH CHARGE: 0
boundary condition: false
initial concentration: 1.0

metaM xyl D e
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
is: SBO:0000247
boundary condition: false
name: aldehydo-D-xylose
has only substance units: false
constant: false
is: CHEBI:15936
initial concentration: 1.0
initial amount: NaN

metaM ksi pre22 g
boundary condition: false
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 22
type: Species
is: SBO:0000247
is: C00130
constant: false
is: CHEBI:58053
is: HMDB00175

http://identifiers.org/biomodels.db/MODEL1310110014#_7987c035_6a2c_4e06_8aa1_601e6e1492fc
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10991
has only substance units: false
is: Q99624
type: Species
name: SLC38A3
initial amount: NaN
constant: false

metaM 5oxpro e
name: 5-oxoprolinate
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
is: HMDB00267
is: SBO:0000247
is: CHEBI:57606

metaR RE3627M
is described by: ECO:0000000
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110014#
is: SBO:0000176
reversible: true
name: RE3627
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:

metaR EX dag hs LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for diglyceride
type: Reaction

metaM nad r
is: CHEBI:57540
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
name: NAD(1-)
is: SBO:0000247
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
is: HMDB00902
constant: false

metaM fuc L l
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
type: Species
is: CHEBI:18287
has only substance units: false
name: L-fucose
constant: false
boundary condition: false
is: HMDB00174

http://identifiers.org/biomodels.db/MODEL1310110014#_9326b6c9_785f_4449_9c4e_449373f2c36e
is encoded by: hsa:316
initial concentration: NaN
name: AOX1
is: SBO:0000252
is: Q06278
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
type: Species

metaR GLYt2r
type: Reaction
kinetic law: MODEL1310110014#
fast: false
is: SBO:0000185
name: glycine reversible transport via proton symport
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is described by: ECO:0000304
modifier: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true

metaR r2367
kinetic law: MODEL1310110014#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110014#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
fast: false
product: MODEL1310110014#

metaR r1562
type: Reaction
kinetic law: MODEL1310110014#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110014#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110014#

metaM dodecanac c
initial concentration: 1.0
is: HMDB00623
boundary condition: false
constant: false
notes: FORMULA: C12H20O4 CHARGE: -2
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
name: Dodecanedioic acid

http://identifiers.org/biomodels.db/MODEL1310110014#_4b4d7402_a999_4f2d_bece_e3793f294bf8
initial amount: NaN
name: _HG2846_HT2983_1_m
constant: false
is encoded by: hsa:HG2846-HT2983
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species

metaM ppi m
constant: false
is: SBO:0000247
is: HMDB00250
is: CHEBI:33019
initial amount: NaN
initial concentration: 1.0
type: Species
is: C00013
name: Diphosphate
boundary condition: false
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013

metaM lnlncgcoa c
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
name: gamma-linolenoyl-CoA(4-)
initial concentration: 1.0
is: HMDB06368
is: CHEBI:57363
type: Species

metaM lnlccoa c
is: HMDB01064
constant: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/5462164
type: Species
name: linoleic coenzyme A

metaM 4mtolbutamide c
name: 4 hydroxy tolbutamide
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB06408
notes: FORMULA: C12H18N2O4S CHARGE: 0 INCHI: InChI=1/C12H18N2O4S/c1-2-3-8-13-12(16)14-19(17,18)11-6-4-10(9-15)5-7-11/h4-7,15H,2-3,8-9H2,1H3,(H2,13,14,16)

metaM 3hmp m
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:11805
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
boundary condition: false
name: 3-hydroxy-2-methylpropanoate
type: Species
initial amount: NaN
is: HMDB00023

metaM hexdpencoa x
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: HMDB02288
name: 2,4,7,10,13-hexadecapentaenoylcoa
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C37H52N7O17P3S CHARGE: -4

metaM oxa e
is: HMDB02329
initial concentration: 1.0
boundary condition: false
is: CHEBI:30623
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
constant: false
type: Species
name: oxalate(2-)
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM CE5120 m
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:57923
name: trans-2-cis-8-tetradecadienoyl-CoA
type: Species
boundary condition: false

metaM c51crn e
constant: false
boundary condition: false
has only substance units: false
type: Species
name: tiglyl carnitine
is: SBO:0000247
initial amount: NaN
is: HMDB02366
notes: FORMULA: C12H21NO4 CHARGE: 0
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_42e3d921_2b44_453b_962d_9f6cf92a8c29
initial concentration: NaN
has only substance units: false
boundary condition: true
name: PRDX2
initial amount: NaN
is encoded by: hsa:7001
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_22685374_5470_4e97_9245_8c8f3f10a646
boundary condition: true
type: Species
is: SBO:0000252
name: ITPA
initial concentration: NaN
is encoded by: hsa:3704
has only substance units: false
constant: false
is: Q9BY32
initial amount: NaN

metaM ddcacoa x
constant: false
name: Dodecanoyl-CoA (n-C12:0CoA)
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: CHEBI:57375
has only substance units: false
is: HMDB03571
type: Species
is: SBO:0000247
is: C01832

metaM ppi r
is: HMDB00250
is: SBO:0000247
name: Diphosphate
type: Species
is: C00013
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial amount: NaN
is: CHEBI:33019
boundary condition: false
initial concentration: 1.0
constant: false

metaR NCNt
kinetic law: MODEL1310110014#
type: Reaction
is described by: ECO:0000269
name: Na+/Ca2+-NH4+ exchange
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
product: MODEL1310110014#
fast: false
is: SBO:0000185
reactant: MODEL1310110014#
reversible: true

metaM cbp m
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: CH2NO5P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00164 EHMN_ABBREVIATION: C00169
is: C00169
is: HMDB01096
has only substance units: false
name: Carbamoyl phosphate
is: CHEBI:58228
type: Species

metaR H2Oter
reactant: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110014#
product: MODEL1310110014#
name: H2O endoplasmic reticulum transport
reversible: true

metaM xyl D c
has only substance units: false
is: CHEBI:15936
initial amount: NaN
name: aldehydo-D-xylose
constant: false
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM dmnoncrn m
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
constant: false
has only substance units: false
is: HMDB06202
boundary condition: false
initial concentration: 1.0
name: 4,8 dimethylnonanoyl carnitine
type: Species
is: SBO:0000247
initial amount: NaN

metaM Asn X Ser Thr r
is: HMDB00051
notes: FORMULA: XH CHARGE: 0
initial concentration: 1.0
has only substance units: false
name: protein-linked asparagine residue (N-glycosylation site)
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: CHEBI:28938
is: C01342

metaR C4STMO2Pr
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.1.1.170
fast: false
is: SBO:0000176
type: Reaction
name: C-4 methyl sterol oxidase
kinetic law: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
is described by: ECO:0000000
modifier: MODEL1310110014#
product: MODEL1310110014#

metaR NP1
kinetic law: MODEL1310110014#
is: SBO:0000176
modifier: MODEL1310110014#
fast: false
type: Reaction
reactant: MODEL1310110014#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.4.2.1
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
name: nucleotide phosphatase
product: MODEL1310110014#
reversible: false

metaM nad x
boundary condition: false
is: SBO:0000247
is: HMDB00902
name: Nicotinamide adenine dinucleotide
is: C00003
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57540
is: http://identifiers.org/pubchem.compound/3305
has only substance units: false
type: Species

metaR D LACt2
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
name: D-lactate transport via proton symport
fast: false
type: Reaction
kinetic law: MODEL1310110014#
is described by: ECO:0000269
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000185
product: MODEL1310110014#
reversible: true

metaR ABO4g
type: Reaction
kinetic law: MODEL1310110014#
fast: false
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
reversible: false
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
is version of: http://identifiers.org/ec-code/2.4.1.37
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110014#
modifier: MODEL1310110014#

metaR DMGDHm
type: Reaction
name: dimethylglycine dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.5.99.2
is described by: ECO:0000269
product: MODEL1310110014#
fast: false
is: SBO:0000176
modifier: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (29958.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10767172,PMID:1123190 NOTES:MM
kinetic law: MODEL1310110014#
reversible: false

metaR r1560
kinetic law: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110014#
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_0f2e084d_1006_4448_83bd_f377952ffc27
name: LPGAT1
type: Species
is encoded by: hsa:9926
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q92604
constant: false

metaR NACHEX11ly
reversible: false
modifier: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
product: MODEL1310110014#
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaR FAOXC225C226m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_68482ab7_4f12_455a_ad7a_894f5e9302ad
initial concentration: NaN
is encoded by: hsa:4711
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: O43674
is: SBO:0000252
name: NDUFB5
constant: false

metaM acald c
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: CHEBI:15343
boundary condition: false
has only substance units: false
type: Species
name: acetaldehyde
initial concentration: 1.0
is: HMDB00990
initial amount: NaN
is: SBO:0000247
constant: false

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

metaR FAOXC163C143m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_da53eca8_8d64_434f_8193_889263cf723a
boundary condition: true
name: _100128062_1_m
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:100128062
has only substance units: false
constant: false
type: Species
initial concentration: NaN

metaM dcdp c
boundary condition: false
initial amount: NaN
name: dCDP
is: HMDB01245
is: CHEBI:58593
initial concentration: 1.0
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
constant: false
is: C00705
type: Species
is: SBO:0000247
has only substance units: false

metaM hxcoa m
has only substance units: false
initial amount: NaN
name: Hexanoyl-CoA (n-C6:0CoA)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
type: Species
is: SBO:0000247
constant: false
is: HMDB06522

metaM dcacoa x
name: Decanoyl-CoA (n-C10:0CoA)
boundary condition: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: CHEBI:61430
has only substance units: false
is: C05274
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB06404

http://identifiers.org/biomodels.db/MODEL1310110014#_3085dc61_da18_4c28_bf14_2f4615b8ee2f
is: SBO:0000252
is: Q5JZF5
name: ALAS2
type: Species
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:212
initial concentration: NaN
initial amount: NaN

metaR GALASE13ly
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18

http://identifiers.org/biomodels.db/MODEL1310110014#_a35f8d7e_9951_40ae_9583_b9fa3c8cc676
initial concentration: NaN
name: MAT2B:MAT2A
boundary condition: true
has part: Q9NZL9
constant: false
is encoded by: hsa:27430
is: SBO:0000297
has only substance units: false
type: Species
initial amount: NaN

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

metaR r0464
type: Reaction
reactant: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000000
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
kinetic law: MODEL1310110014#

metaR OMPDC
name: orotidine-5'-phosphate decarboxylase
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
is version of: http://identifiers.org/ec-code/2.4.2.10
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110014#_metaM_galacgalfucgalacglcgal14acglcgalgluside_hs_g
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:26174
constant: false
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1
boundary condition: false
notes: FORMULA: C78H135N4O46FULLRCO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110014#_63890269_6790_4097_adf2_da0595c00de1
initial amount: NaN
has only substance units: false
is: O43451
initial concentration: NaN
is encoded by: hsa:8972
constant: false
type: Species
name: MGAM
boundary condition: true
is: SBO:0000252

metaM gpail hs c
initial concentration: 1.0
boundary condition: false
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
is: SBO:0000247
has only substance units: false
is: CHEBI:17049
type: Species
constant: false
initial amount: NaN

metaR LEULEULAPc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Leucylleucine in the small intestine for cellular uptake
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_546ab8e1_baeb_460a_aad6_4354a4d11540
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q9Y2A9
constant: false
name: B3GNT3
is: SBO:0000252
type: Species
is encoded by: hsa:10331

http://identifiers.org/biomodels.db/MODEL1310110014#_ae4e3230_2876_4d46_a46f_5fddd5390603
type: Species
is encoded by: hsa:27306
name: HPGDS
is: O60760
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN

metaR r2511
name: Utilized transport
product: MODEL1310110014#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
kinetic law: MODEL1310110014#
reversible: true
reactant: MODEL1310110014#

metaM dutp c
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: C00460
name: dUTP
type: Species
initial amount: NaN
is: HMDB01191
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17625
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_534a7be2_08c4_473f_9134_6cb2e81ba72c
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
name: SLC8A3
is encoded by: hsa:6547
constant: false
initial concentration: NaN

metaR LPS3e
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
reversible: false
product: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
name: lipase, extracellular
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110014#_3f0eb339_1e76_4a0b_b57a_666037b4ba9c
initial amount: NaN
name: GLUD1
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is: E9KL48
is: SBO:0000252
is encoded by: hsa:2746
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_0ccadd6c_9094_46b1_aea2_b516dbcd52a4
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6391
has only substance units: false
type: Species
is: SBO:0000252
is: Q99643
initial amount: NaN
name: SDHC
constant: false

metaM acald m
boundary condition: false
type: Species
initial amount: NaN
name: acetaldehyde
has only substance units: false
is: SBO:0000247
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial concentration: 1.0
is: HMDB00990
constant: false
is: CHEBI:15343

metaM paf hs e
initial concentration: 1.0
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
constant: false
type: Species
is: CHEBI:36707
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0

metaR CYSGLTH
product: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
reactant: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
is: SBO:0000176
name: Glutathione:cystine oxidoreductase
reversible: true
is described by: ECO:0000000

metaR r2362
type: Reaction
product: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110014#
name: Organic anion transporter 5 Utilized transport

metaM octdececrn m
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C25H47NO4 CHARGE: 0
has only substance units: false
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
initial amount: NaN
initial concentration: 1.0
is: HMDB06351
type: Species

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaR LCADi D
kinetic law: MODEL1310110014#
reversible: false
fast: false
type: Reaction
name: lactaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110014#_1076bafb_ec19_41a3_b050_456c88da5d2e
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:26330
name: GAPDHS
is: O14556
constant: false
initial amount: NaN
has only substance units: false

metaR PPCDC
modifier: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.36
reactant: MODEL1310110014#
is described by: ECO:0000269
kinetic law: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
reversible: false
name: phosphopantothenoylcysteine decarboxylase

http://identifiers.org/biomodels.db/MODEL1310110014#_5981fa67_ebbd_4e6c_b89d_59f741df5a07
is encoded by: hsa:8854
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: ALDH1A2
initial concentration: NaN
constant: false
is: SBO:0000252
is: B4DZR2

metaM mercppyr c
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:57678
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
constant: false
is: SBO:0000247
name: 3-mercaptopyruvate
is: HMDB01368

http://identifiers.org/biomodels.db/MODEL1310110014#_04f87f68_4619_421a_8657_5aeb48ddf234
name: SLC27A5
type: Species
initial concentration: NaN
is encoded by: hsa:10998
constant: false
is: Q9Y2P5
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_10fe8227_5d61_4d05_9ea8_946882344898
initial amount: NaN
name: SLC2A7
is: Q6PXP3
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:155184
boundary condition: true

metaR PRGSTRNt
is: SBO:0000185
kinetic law: MODEL1310110014#
type: Reaction
fast: false
product: MODEL1310110014#
name: Progesterone transport
reversible: true
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000

metaR r2039
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
type: Reaction
modifier: MODEL1310110014#
reactant: MODEL1310110014#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110014#

metaM ocdca e
boundary condition: false
is: SBO:0000247
is: C01530
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00827
constant: false
initial concentration: 1.0
is: CHEBI:25629
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
name: octadecanoate (n-C18:0)

metaM fuc L e
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:18287
constant: false
name: L-fucose
has only substance units: false
initial concentration: 1.0
is: HMDB00174
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626

metaR SUCCOAPET
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaM zym int2 r
initial amount: NaN
is: SBO:0000247
name: zymosterol intermediate 2
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
constant: false
is: CHEBI:52386
type: Species

metaM urcan c
is: CHEBI:17771
has only substance units: false
boundary condition: false
is: HMDB00301
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
is: SBO:0000247
name: Urocanate
is: C00785

http://identifiers.org/biomodels.db/MODEL1310110014#_93a30cd7_e541_4082_8ed5_4b5d72382f2e
type: Species
has only substance units: false
initial concentration: NaN
is: P47895
initial amount: NaN
name: ALDH1A3
constant: false
boundary condition: true
is encoded by: hsa:220
is: SBO:0000252

metaR r2361
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110014#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
product: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true

metaR r0002
type: Reaction
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
is: SBO:0000185
name: Active transport
is described by: ECO:0000000
fast: false
product: MODEL1310110014#
reversible: true

metaM betald c
type: Species
has only substance units: false
name: betaine aldehyde
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
is: CHEBI:15710
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB01252

http://identifiers.org/biomodels.db/MODEL1310110014#_f437e637_cae7_42f9_93bb_446ba8011f59
initial concentration: NaN
is: SBO:0000252
name: KL
constant: false
has only substance units: false
is: Q9UEF7
is encoded by: hsa:9365
initial amount: NaN
type: Species
boundary condition: true

metaR 24NPHte
type: Reaction
kinetic law: MODEL1310110014#
name: xenobiotic transport
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Steriods transported by free diffusion
product: MODEL1310110014#
reactant: MODEL1310110014#
fast: false

metaR DCSPTN1t
kinetic law: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110014#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110014#
type: Reaction
name: fatty acid transport via diffusion
fast: false

metaR C9BRxtc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dimethylnonanoylcarnitine from peroxisomes to cytosol
type: Reaction

metaM ptdcacoa m
type: Species
initial amount: NaN
has only substance units: false
name: pentadecanoyl Coenzyme A
constant: false
initial concentration: 1.0
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
is: HMDB06499
is: SBO:0000247
boundary condition: false

metaR GALtly
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
name: galactose efflux from lysosome
product: MODEL1310110014#
is: SBO:0000185
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000000
type: Reaction

metaR r2360
product: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110014#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR MACACI
is: SBO:0000176
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
type: Reaction
reactant: MODEL1310110014#
name: maleylacetoacetate isomerase
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.18
fast: false
is described by: ECO:0000269
product: MODEL1310110014#
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#

metaM xol7ah3 m
boundary condition: false
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha,26-triol
initial amount: NaN
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
type: Species
is: HMDB12455
constant: false
is: CHEBI:28540
is: SBO:0000247
initial concentration: 1.0

metaM 4mtolbutamide e
initial concentration: 1.0
name: 4 hydroxy tolbutamide
notes: FORMULA: C12H18N2O4S CHARGE: 0 INCHI: InChI=1/C12H18N2O4S/c1-2-3-8-13-12(16)14-19(17,18)11-6-4-10(9-15)5-7-11/h4-7,15H,2-3,8-9H2,1H3,(H2,13,14,16)
is: SBO:0000247
is: HMDB06408
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: false

metaM acnacngalgbside hs c
constant: false
initial concentration: 1.0
is: HMDB00223
has only substance units: false
is: SBO:0000247
name: disialyl galactosylgloboside
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
type: Species
initial amount: NaN
boundary condition: false
is: C00036
is: CHEBI:3338

http://identifiers.org/biomodels.db/MODEL1310110014#_a0e963d6_7083_4e32_bccc_983d9a5c801c
initial amount: NaN
name: ELOVL1
has only substance units: false
is encoded by: hsa:64834
is: Q9BW60
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
boundary condition: true

metaM fuc L c
boundary condition: false
name: L-fucose
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:18287
initial concentration: 1.0
constant: false
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
is: HMDB00174

metaM ppi e
has only substance units: false
constant: false
boundary condition: false
is: C00013
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: CHEBI:33019
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
name: Diphosphate
is: HMDB00250

metaR RE3346C
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110014#
kinetic law: MODEL1310110014#
name: RE3346

http://identifiers.org/biomodels.db/MODEL1310110014#_9a44b9bc_6af9_480b_b399_6ee94a02a695
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:1635
is: SBO:0000252
name: DCTD
constant: false
boundary condition: true
is: P32321

metaR r0735
is: SBO:0000176
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
product: MODEL1310110014#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_3cd88975_aa66_47b7_bc0b_d2f19ff548ed
name: MAN1B1
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:11253
is: Q9UKM7
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_7751be5e_0874_44df_aed7_b0c4db678bd3
boundary condition: true
has only substance units: false
name: _W74642_1_c
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:W74642
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_16e7626c_428a_45f0_88ca_1b8ac0e84296
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: CRAT
is: SBO:0000252
is encoded by: hsa:1384
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_efc7d8de_b273_49a1_bebe_42338a8b813e
is encoded by: hsa:2519
is: Q9BTY2
constant: false
initial amount: NaN
type: Species
name: FUCA2
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaM eicostetcrn c
initial amount: NaN
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
is: HMDB01356
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57312
type: Species
name: Eicosatetranoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110014#_b7912dd2_9ba3_4886_a3fb_372463a92703
constant: false
is encoded by: hsa:AI653169
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: _AI653169_1_c
has only substance units: false
type: Species
is: SBO:0000252

metaM udpacgal c
has only substance units: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
constant: false
boundary condition: false
is: HMDB00304
is: CHEBI:57847
is: SBO:0000247
initial amount: NaN
type: Species
name: UDP-N-acetyl-D-galactosamine(2-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_924c3ae6_1867_4e15_9650_adeaecd6f2a0
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: P21399
is encoded by: hsa:48
is: SBO:0000252
has only substance units: false
constant: false
name: ACO1

http://identifiers.org/biomodels.db/MODEL1310110014#_01cbbbcd_b1bc_4ce9_bca2_c832a78b51d5
constant: false
is encoded by: hsa:113026
initial concentration: NaN
type: Species
initial amount: NaN
is: Q8N3E9
boundary condition: true
name: PLCD3
is: SBO:0000252
has only substance units: false

metaR TRIODTHYt
name: T3 transport via bicarbonate countertransport
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (28234.1) or (28231.1) or (10599.1) or (6579.1) or (53919.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
reactant: MODEL1310110014#
fast: false
product: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110014#

metaR r1836
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110014#
type: Reaction
name: Y+LAT2 Utilized transport
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: false

metaR r2366
kinetic law: MODEL1310110014#
reversible: true
is described by: ECO:0000000
product: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_0722f124_5404_49c7_b28c_a53aeeb3258e
boundary condition: true
type: Species
is encoded by: hsa:AA664770
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
name: _AA664770_1_m
initial amount: NaN

metaR ARACHCPT1
is described by: ECO:0000000
reactant: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110014#
fast: false
name: carnitine transferase
kinetic law: MODEL1310110014#
reversible: false

metaM ksi deg25 l
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00812
is: CHEBI:16953
name: keratan sulfate I, degradation product 25
initial amount: NaN
constant: false
notes: FORMULA: C118H192N8O98S4 CHARGE: -4
is: SBO:0000247

metaM dcdp n
boundary condition: false
is: CHEBI:58593
initial concentration: 1.0
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
name: dCDP(3-)
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
is: HMDB01245
type: Species

metaM 3octdece1crn e
name: 3-hydroxy-octadecenoyl carnitine
boundary condition: false
is: HMDB13336
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C25H47NO5 CHARGE: 0
is: SBO:0000247

metaM acnacngalgbside hs e
type: Species
name: disialyl galactosylgloboside
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
initial concentration: 1.0
is: CHEBI:3338
is: C00036
boundary condition: false
constant: false
is: HMDB00223

metaR FAOXC185C164m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

metaM oxa m
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: CHEBI:30623
has only substance units: false
initial concentration: 1.0
name: oxalate(2-)
is: HMDB02329

metaR PYDXDH
is: SBO:0000176
type: Reaction
modifier: MODEL1310110014#
is described by: ECO:0000269
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.2.3.1
fast: false
kinetic law: MODEL1310110014#
product: MODEL1310110014#
name: pyridoxal dehydrogenase
reversible: false
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.2.3.1 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:IT

metaR ACGALtlg
type: Reaction
name: N-acetyl-galactosamine intracellular transport
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism - may be vesicular NJ
is described by: ECO:0000000
product: MODEL1310110014#
is: SBO:0000185
fast: false
reversible: true

metaR DHCRD2
is: SBO:0000176
modifier: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
is described by: ECO:0000269
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
fast: false
reversible: false
kinetic law: MODEL1310110014#
name: dihydroceramide desaturase

metaR HEX1
reactant: MODEL1310110014#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.2
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.1
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
name: hexokinase (D-glucose:ATP)
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_0ff0f8c5_6f02_432f_bb9f_12ab824a5c8b
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: DGKH
is encoded by: hsa:160851
type: Species
boundary condition: true
is: A8K0I1
initial concentration: NaN

metaM HC01118 r
boundary condition: false
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
constant: false
initial amount: NaN
name: presqualene diphosphate(3-)
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:57310
has only substance units: false

metaR FACOAL1832
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110014#
type: Reaction
fast: false
name: fatty-acid--CoA ligase
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE3114C
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
kinetic law: MODEL1310110014#

metaM dcamp c
is: C03794
has only substance units: false
initial amount: NaN
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
initial concentration: 1.0
boundary condition: false
is: HMDB00536
type: Species
is: CHEBI:57567
constant: false
is: SBO:0000247
name: N6-(1,2-Dicarboxyethyl)-AMP

metaR GTHPm
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.11.1.12
is: SBO:0000176
reactant: MODEL1310110014#
reversible: true
is version of: http://identifiers.org/ec-code/1.11.1.15
product: MODEL1310110014#
fast: false
modifier: MODEL1310110014#
type: Reaction
name: glutathione peroxidase, mitochondria
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
is described by: ECO:0000269

metaM pristanal c
name: pristanal
is: HMDB01958
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:49189
initial amount: NaN
constant: false
boundary condition: false
type: Species
notes: FORMULA: C19H38O CHARGE: 0 INCHI: InChI=1S/C19H38O/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20/h15-19H,6-14H2,1-5H3
has only substance units: false

metaM lnlncgcoa m
is: HMDB06368
type: Species
is: SBO:0000247
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: CHEBI:57363
initial concentration: 1.0
boundary condition: false
name: gamma-linolenoyl-CoA(4-)
has only substance units: false
constant: false
initial amount: NaN

metaM idp e
name: IDP(3-)
initial concentration: 1.0
has only substance units: false
is: HMDB03335
is: SBO:0000247
constant: false
type: Species
is: CHEBI:58280
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial amount: NaN
boundary condition: false

metaR r0715
is version of: http://identifiers.org/ec-code/6.3.2.5
modifier: MODEL1310110014#
fast: false
reactant: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: false
is described by: ECO:0000000
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is: SBO:0000176

metaR r2365
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
product: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reversible: true
is described by: ECO:0000000

metaM prist x
constant: false
is: SBO:0000247
is: CHEBI:51340
has only substance units: false
name: pristanic acid
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
initial concentration: 1.0
is: HMDB00795

http://identifiers.org/biomodels.db/MODEL1310110014#_cb51a8c9_5f63_4a3c_b7c9_71e2927d025d
is: Q6FH48
initial amount: NaN
has only substance units: false
is encoded by: hsa:443
boundary condition: true
type: Species
is: SBO:0000252
name: ASPA
initial concentration: NaN
constant: false

metaM dcacoa m
initial amount: NaN
name: Decanoyl-CoA (n-C10:0CoA)
type: Species
is: HMDB06404
is: CHEBI:61430
initial concentration: 1.0
constant: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: C05274
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM 3tetd7ecoa c
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB05066
constant: false
type: Species
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
name: 3-hydroxy tetradecenoyl-7-coa
has only substance units: false

metaM adp c
is: CHEBI:16761
is: C00008
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: ADP
type: Species
is: HMDB01341
has only substance units: false
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3310

metaM fuc1p L c
name: L-Fucose 1-phosphate
is: HMDB01265
initial concentration: 1.0
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
initial amount: NaN
is: CHEBI:28319
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_e6debc91_196b_48da_ba3f_4024ad2eeec5
initial concentration: NaN
constant: false
has only substance units: false
name: IDH1
type: Species
initial amount: NaN
boundary condition: true
is: O75874
is: SBO:0000252
is encoded by: hsa:3417

metaR ARACHCPT2
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
reversible: false
is: SBO:0000176
product: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#

metaR r1670
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110014#
reactant: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110014#
reversible: true
fast: false
name: Y+LAT2 Utilized transport
is: SBO:0000185

metaM 56dura c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00076
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
name: 5,6-dihydrouracil
constant: false
boundary condition: false
type: Species
is: CHEBI:15901
is: SBO:0000247

metaM strdnccrn m
initial concentration: 1.0
name: stearidonyl carnitine
type: Species
notes: FORMULA: C25H41NO4 CHARGE: 0 INCHI: InChI=1/C25H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h6-7,9-10,13-14,17-18,23H,5,8,11-12,15-16,19-22H2,1-4H3/b7-6-,10-9-,14-13-,18-17-
is: SBO:0000247
is: HMDB06463
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false

metaR r0718
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: false
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.181

metaM HC01407 m
boundary condition: false
initial amount: NaN
name: (S)-Hydroxyhexanoyl-CoA
constant: false
type: Species
is: CHEBI:28276
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
is: SBO:0000247

metaM c12dc x
boundary condition: false
name: dodecanedioyl carnitine
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C19H34NO6 CHARGE: -1
has only substance units: false
is: C05279
type: Species
is: HMDB11123
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_5cd7dd87_c525_426d_91da_19ea9cd46f1a
is encoded by: hsa:9856
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is: F5H123
has only substance units: false
name: DYLX2
initial amount: NaN

metaM hexe3coa x
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB06522
is: SBO:0000247
has only substance units: false
constant: false
name: 3-hexenoylcoa
type: Species
notes: FORMULA: C27H40N7O17P3S CHARGE: -4

metaR r2364
kinetic law: MODEL1310110014#
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110014#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reactant: MODEL1310110014#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110014#_31bd8f0f_c645_486e_8911_33ee16e5ae2c
is encoded by: hsa:171425
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
name: CLYBL
constant: false
is: SBO:0000252
initial amount: NaN

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_66e16082_ffec_4cbd_ba41_49db0fcd4aa4
boundary condition: true
is encoded by: hsa:89874
has only substance units: false
initial amount: NaN
name: SLC25A21
type: Species
is: SBO:0000252
is: G3V4L5
initial concentration: NaN
constant: false

metaR DMNONCOACRNCPT1
is described by: ECO:0000000
fast: false
reactant: MODEL1310110014#
name: DMNONCOACRNCPT1
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110014#_23d9a0b0_962b_4e3f_a464_8391d3f6c5cd
boundary condition: true
is encoded by: hsa:23475
name: QPRT
is: Q15274
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
type: Species

metaM 3octdece1crn c
name: 3-hydroxy-octadecenoyl carnitine
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB13336
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C25H47NO5 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110014#_08e6260a_856a_4a7e_9a09_19e2c9b578d9
type: Species
name: GGT3P
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:2679
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_0c6027b9_5543_4c8c_8800_0d42aa34f527
constant: false
initial amount: NaN
is: Q16773
is encoded by: hsa:883
initial concentration: NaN
boundary condition: true
name: CCBL1
has only substance units: false
type: Species
is: SBO:0000252

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaR TTDCAFATPc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaR FAOXC103C102x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)x
type: Reaction

metaM acnacngalgbside hs g
is: C00036
constant: false
is: HMDB00223
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
name: disialyl galactosylgloboside
has only substance units: false
initial amount: NaN
is: CHEBI:3338

metaR r0739
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:
fast: false
reversible: true
modifier: MODEL1310110014#
product: MODEL1310110014#
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
kinetic law: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110014#_d2c70b25_9c49_40a4_92d1_e058077203e5
boundary condition: true
name: NME4
is: O00746
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:4833
is: SBO:0000252
initial concentration: NaN
constant: false

metaR INSt
name: Inosine transport (diffusion)
reactant: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
fast: false
reversible: true
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_79031055_207a_4a00_b802_bd2d5e302edd
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10587
initial amount: NaN
is: Q9NNW7
constant: false
name: TXNRD2

http://identifiers.org/biomodels.db/MODEL1310110014#_fd178fd7_38d4_423f_81d6_2fda767331c6
has only substance units: false
type: Species
constant: false
is encoded by: hsa:AA977580
initial amount: NaN
is: SBO:0000252
name: _AA977580_1_c
initial concentration: NaN
boundary condition: true

metaR r1671
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110014#
reactant: MODEL1310110014#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110014#
fast: false
modifier: MODEL1310110014#
type: Reaction

metaR CSEPASEly
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
type: Reaction
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
is: SBO:0000176
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110014#
fast: false
reactant: MODEL1310110014#

metaR r2363
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110014#
name: Organic anion transporter 5 Utilized transport
type: Reaction
fast: false
reactant: MODEL1310110014#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110014#

metaM ach n
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:15355
constant: false
is: HMDB00895
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
name: acetylcholine

metaR r0717
reactant: MODEL1310110014#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
product: MODEL1310110014#
is: SBO:0000176
kinetic law: MODEL1310110014#
reversible: false
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

metaM idp c
has only substance units: false
initial concentration: 1.0
name: IDP(3-)
is: HMDB03335
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: SBO:0000247
type: Species
constant: false
is: CHEBI:58280
boundary condition: false
initial amount: NaN

metaM dmnoncrn c
initial amount: NaN
is: HMDB06202
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
name: 4,8-dimethylnonanoyl carnitine
has only substance units: false
notes: FORMULA: C18H37NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110014#_d45fc991_7d14_4afa_86bc_3eb68929b8a0
is encoded by: hsa:7296
is: SBO:0000252
initial amount: NaN
name: TXNRD1
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_d62e9aa1_fc5f_41c6_bc16_4e6e1df40914
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: P50440
is encoded by: hsa:2628
initial concentration: NaN
name: GATM
has only substance units: false

metaR r1996
type: Reaction
product: MODEL1310110014#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110014#
reversible: false
fast: false
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000185
is described by: ECO:0000000

metaR r2519
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110014#
name: Utilized transport
product: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
reactant: MODEL1310110014#
is: SBO:0000185

metaM adp e
is: CHEBI:456216
name: ADP(3-)
is: SBO:0000247
initial concentration: 1.0
is: HMDB01341
type: Species
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008

metaM cholcoar x
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: HMDB02178
is: CHEBI:58677
is: SBO:0000247
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)

metaM dcdp m
type: Species
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: CHEBI:58593
name: dCDP(3-)
is: HMDB01245
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN

metaR r0311
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: false
modifier: MODEL1310110014#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110014#
fast: false
reactant: MODEL1310110014#
type: Reaction
is: SBO:0000176
product: MODEL1310110014#

metaM thm c
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00235
is: CHEBI:0
name: Thiamin
is: C00378
boundary condition: false
constant: false
notes: FORMULA: C12H17N4OS CHARGE: 1
initial amount: NaN
has only substance units: false

metaR AGTim
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
product: MODEL1310110014#
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.6.1.44

metaM udpacgal g
is: CHEBI:57847
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00304
constant: false
boundary condition: false
initial concentration: 1.0
name: UDP-N-acetyl-D-galactosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203

metaM 10fthf5glu e
has only substance units: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00972
boundary condition: false
is: CHEBI:57454
name: 10-formyltetrahydrofolate-[Glu](5)
notes: FORMULA: C40H45N11O19 CHARGE: -6
initial concentration: 1.0

metaR CSNATr
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
reactant: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: true
name: carnitine O-acetyltransferase
product: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#

metaR HEX4
is version of: http://identifiers.org/ec-code/2.7.1.2
product: MODEL1310110014#
is: SBO:0000176
reactant: MODEL1310110014#
type: Reaction
name: hexokinase (D-mannose:ATP)
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.1.1
reversible: false
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
fast: false
kinetic law: MODEL1310110014#
is described by: ECO:0000304

metaM nac e
has only substance units: false
name: Nicotinate
is: SBO:0000247
notes: FORMULA: C6H4NO2 CHARGE: -1
boundary condition: false
is: HMDB01488
type: Species
is: C00253
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:0

metaR r0741
modifier: MODEL1310110014#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m
is: SBO:0000176
kinetic law: MODEL1310110014#
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
reactant: MODEL1310110014#
product: MODEL1310110014#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_5fa40e6f_8b90_484b_b742_84b67043e873
has only substance units: false
type: Species
is: A8K5J1
constant: false
initial amount: NaN
boundary condition: true
name: UMPS
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:7372

metaR 3HKYNAKGAT
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.7
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
modifier: MODEL1310110014#
reversible: false
product: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.64

metaR ITCOAL1m
reversible: true
kinetic law: MODEL1310110014#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176
fast: false
reactant: MODEL1310110014#
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
modifier: MODEL1310110014#
product: MODEL1310110014#
type: Reaction

metaR UMPK3n
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110014#
name: UMP kinase (UTP),nuclear
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
kinetic law: MODEL1310110014#
type: Reaction
reversible: true
is: SBO:0000176
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_a4d8ae1d_5f18_4d36_a147_82e2fc9d608b
is: O60488
type: Species
name: ACSL4
has only substance units: false
is encoded by: hsa:2182
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM lnlncgcoa r
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
has only substance units: false
name: gamma-linolenoyl-CoA(4-)
is: HMDB06368
initial concentration: 1.0
type: Species
is: CHEBI:57363
initial amount: NaN

metaM xol7ah3 c
initial concentration: 1.0
has only substance units: false
is: HMDB12455
name: 5beta-cholestane-3alpha,7alpha,26-triol
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:28540

http://identifiers.org/biomodels.db/MODEL1310110014#_991415e4_a60a_4480_8836_2e1370650dfa
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:53919
name: SLCO1C1
is: Q5JPA4
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR SRTNt6 2 r
fast: false
is described by: ECO:0000269
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110014#
modifier: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110014#_8d64dd2a_2784_4e2f_be4e_e6b2bdc08f9e
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
is: O95340
name: PAPSS2
initial amount: NaN
is encoded by: hsa:9060

metaR AKR1D2
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.3
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
product: MODEL1310110014#
is: SBO:0000176
reactant: MODEL1310110014#
modifier: MODEL1310110014#
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
reversible: false
fast: false
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_a36d098e_4796_47cc_80ab_e7a361698ae0
constant: false
has only substance units: false
boundary condition: true
type: Species
is: P57054
is encoded by: hsa:51227
initial concentration: NaN
initial amount: NaN
name: PIGP
is: SBO:0000252

metaM nad c
is: HMDB00902
constant: false
initial concentration: 1.0
is: C00003
boundary condition: false
initial amount: NaN
is: CHEBI:57540
name: Nicotinamide adenine dinucleotide
type: Species
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3305

metaR EX chol LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Choline
type: Reaction

metaM ahcys c
is: SBO:0000247
is: C00021
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:16680
name: S-Adenosyl-L-homocysteine
is: HMDB00939
constant: false
boundary condition: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021

metaR r0196
kinetic law: MODEL1310110014#
is described by: ECO:0000000
modifier: MODEL1310110014#
product: MODEL1310110014#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110014#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
reversible: true

metaM m2mpdol L c
notes: FORMULA: C1420H2328N20O320P20 CHARGE: -20
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species
is: CHEBI:28049
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false

metaR BTNPL
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
is version of: http://identifiers.org/ec-code/6.3.4.10
modifier: MODEL1310110014#
name: holocarboxylase synthestase (biotin protein ligase)
fast: false
is: SBO:0000176
product: MODEL1310110014#
reactant: MODEL1310110014#
reversible: false
type: Reaction
kinetic law: MODEL1310110014#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110014#_ae262b9b_e8b5_4d09_a389_ea846217a46c
is: Q9NQR4
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:56954
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
name: NIT2

metaR r0892
fast: false
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.2.27
name: Facilitated diffusion
type: Reaction
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
reversible: true
kinetic law: MODEL1310110014#

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

metaM hxcoa x
initial amount: NaN
constant: false
is: HMDB00705
has only substance units: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
name: Hexanoyl-CoA (n-C6:0CoA)
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaR HEXDCRNe
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecanoyl carnitine into extra cellular space
type: Reaction

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_ef0b8e50_ee48_4095_a5a9_297abf85922d
has only substance units: false
is encoded by: hsa:4720
initial concentration: NaN
is: B7Z792
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: NDUFS2
type: Species

metaR r0193
is described by: ECO:0000000
reactant: MODEL1310110014#
fast: false
type: Reaction
product: MODEL1310110014#
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
kinetic law: MODEL1310110014#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_a549715d_02e7_4838_9363_da21cb237f2b
initial amount: NaN
is encoded by: hsa:5210
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: Q16877
name: PFKFB4
is: SBO:0000252
has only substance units: false

metaR r1675
kinetic law: MODEL1310110014#
product: MODEL1310110014#
name: Y+LAT2 Utilized transport
reversible: false
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
is described by: ECO:0000000

metaM biliverd c
has only substance units: false
type: Species
name: biliverdin(2-)
is: HMDB01008
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
constant: false
is: CHEBI:57991
boundary condition: false

metaR r0009
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.1
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
is described by: ECO:0000000
fast: false
reactant: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
reversible: false
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_7b1d21c5_4e71_4ff3_844e_5ab62e6243c6
is encoded by: hsa:4700
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: NDUFA6
constant: false
has only substance units: false
type: Species
is: P56556
initial concentration: NaN

metaR CSNATm
reversible: true
modifier: MODEL1310110014#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.7
is: SBO:0000176
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
fast: false
product: MODEL1310110014#
reactant: MODEL1310110014#
name: carnitine O-aceyltransferase, mitochondrial

metaM arachcoa c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:15527
has only substance units: false
initial amount: NaN
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
type: Species
is: HMDB04258
name: arachidyl coenzyme A

metaR CHATn
is described by: ECO:0000269
type: Reaction
fast: false
modifier: MODEL1310110014#
product: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.6
is: SBO:0000176
reactant: MODEL1310110014#
name: Choline O-acetyltransferase

http://identifiers.org/biomodels.db/MODEL1310110014#_9803e30b_b8fa_4473_a91d_33c2c3bab5de
is: SBO:0000252
is: Q9NWW6
initial amount: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:54981
has only substance units: false
initial concentration: NaN
name: NMRK1

metaR GALASE18ly
modifier: MODEL1310110014#
name: beta-galactosidase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000000
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false

metaM chol e
has only substance units: false
type: Species
name: Choline
initial amount: NaN
is: SBO:0000247
is: HMDB00097
boundary condition: false
is: C00114
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial concentration: 1.0
is: CHEBI:15354
constant: false

metaM appnn c
type: Species
has only substance units: false
is: CHEBI:28261
name: (+)-alpha-pinene
initial amount: NaN
constant: false
is: HMDB06525
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H16 CHARGE: 0 INCHI: InChI=1S/C10H16/c1-7-4-5-8-6-9(7)10(8,2)3/h4,8-9H,5-6H2,1-3H3/t8-,9-/m1/s1
boundary condition: false

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaM ahcys e
notes: FORMULA: C14H20N6O5S CHARGE: 0
is: C00021
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:16680
constant: false
is: HMDB00939
name: S-Adenosyl-L-homocysteine
boundary condition: false
is: SBO:0000247

metaM s2l2fn2m2masn e
is: SBO:0000247
notes: FORMULA: C90H145N6O65X CHARGE: -2
name: PA6
boundary condition: false
type: Species
has only substance units: false
is: C00255
is: CHEBI:3554
is: HMDB00244
constant: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_dccd91bc_0579_459f_a486_af74ca485b7b
constant: false
initial amount: NaN
name: LDHD
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is: Q86WU2
initial concentration: NaN
is encoded by: hsa:197257

metaM xol7a r
name: 20-hydroxycholesterol
initial concentration: 1.0
is: SBO:0000247
is: HMDB01496
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
initial amount: NaN
has only substance units: false
is: CHEBI:1296
boundary condition: false
type: Species

metaM cholcoar r
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
initial amount: NaN
type: Species
constant: false
is: HMDB02178
is: SBO:0000247
is: CHEBI:58677
has only substance units: false
boundary condition: false
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_80be30e6_2e6d_4e3b_a7c2_98484b7ed8b6
constant: false
is encoded by: hsa:8527
has only substance units: false
type: Species
is: SBO:0000252
name: DGKD
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR r2040
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110014#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110014#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110014#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110014#

metaR FACOAL1831
type: Reaction
kinetic law: MODEL1310110014#
name: fatty-acid--CoA ligase
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110014#
reversible: true
is described by: ECO:0000269
is: SBO:0000176
fast: false
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110014#_31f225de_b54f_45c8_ae71_ad76f4f99c5a
type: Species
constant: false
initial amount: NaN
name: HMGCS1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3157
has only substance units: false

metaR HSPGtly
reversible: false
product: MODEL1310110014#
name: heparan sulfate transport, extracellular to lysosome
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaR PRISTCOAtcx
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

metaR RE2973C
is: SBO:0000176
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
modifier: MODEL1310110014#
is described by: ECO:0000000
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.1.154
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.137
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
name: RE2973
is version of: http://identifiers.org/ec-code/2.7.1.153

metaR NACHEX9ly
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_18f890dd_dd11_4b71_8346_7b650b484339
name: AGXT2
is: Q9BYV1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:64902
constant: false
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true

metaM triodthy c
constant: false
boundary condition: false
is: CHEBI:18258
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
initial concentration: 1.0
initial amount: NaN
is: HMDB00265
is: SBO:0000247
has only substance units: false
type: Species
name: 3,3',5-triiodo-L-thyronine

metaM asp D x
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
is: SBO:0000247
name: D-aspartate(1-)
is: CHEBI:29990
type: Species
boundary condition: false
is: HMDB06483
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaM 3hdeccoa c
type: Species
initial concentration: 1.0
is: HMDB02014
has only substance units: false
name: 3-hydroxyhexadecenoylcoa
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN

metaR AG13T4g
reactant: MODEL1310110014#
type: Reaction
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
is described by: ECO:0000000
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false

metaM xol27oh m
constant: false
type: Species
initial amount: NaN
is: CHEBI:17703
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
boundary condition: false
is: HMDB02103
initial concentration: 1.0
name: 26-hydroxycholesterol
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_0266568c_0d51_4166_b91e_b70358fe108d
is: Q99714
initial concentration: NaN
is: SBO:0000252
constant: false
name: HSD17B10
is encoded by: hsa:3028
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_16fa8a58_8c4b_4fc8_bddd_19cf12643227
is: P12074
boundary condition: true
constant: false
is: SBO:0000252
name: COX6A1
has only substance units: false
is encoded by: hsa:1337
type: Species
initial amount: NaN
initial concentration: NaN

metaR r0720
reactant: MODEL1310110014#
type: Reaction
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
is: SBO:0000176
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_e341371d_a1db_459a_8fef_72e7ccefc6b5
name: SLC20A1
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:6574
is: Q8WUM9

metaM chol c
name: Choline
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00097
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial amount: NaN
is: C00114
is: CHEBI:15354
has only substance units: false

metaR NACDe
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

metaR UGALNACtg
product: MODEL1310110014#
is described by: ECO:0000269
type: Reaction
fast: false
modifier: MODEL1310110014#
name: UDP-GalNAc Golgi transport via CMP antiport
reversible: true
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110014#_2b340b69_7c87_40b5_8516_9722dfc00609
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
name: BDH1
initial amount: NaN
is encoded by: hsa:622

metaR BILIRED
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
name: Nad(p)h biliverdin reductase
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.24
type: Reaction
reactant: MODEL1310110014#
is: SBO:0000176
fast: false
reversible: false
modifier: MODEL1310110014#

metaM etoh c
initial amount: NaN
name: ethanol
is: CHEBI:16236
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
is: HMDB00108
constant: false
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469

metaM gal c
type: Species
is: HMDB00143
notes: FORMULA: C6H12O6 CHARGE: 0
is: SBO:0000247
name: D-Galactose
initial concentration: 1.0
constant: false
is: CHEBI:0
boundary condition: false
initial amount: NaN
has only substance units: false
is: C00124

http://identifiers.org/biomodels.db/MODEL1310110014#_931f5779_fbaf_45cf_87a8_3a7513e086f8
is: SBO:0000252
name: ENTPD6
has only substance units: false
boundary condition: true
is: O75354
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:955
initial concentration: NaN

metaM omeprazole e
is: SBO:0000247
has only substance units: false
type: Species
name: omeprazole
is: HMDB01913
is: CHEBI:7772
boundary condition: false
notes: FORMULA: C17H19N3O3S CHARGE: 0 INCHI: InChI=1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
initial concentration: 1.0
initial amount: NaN
constant: false

metaR FACOAL181i
is described by: ECO:0000269
type: Reaction
product: MODEL1310110014#
reversible: false
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
name: C181 fatty acid activation
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
is: SBO:0000176

metaM nadh c
type: Species
is: SBO:0000247
is: HMDB01487
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:57945
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3306
is: C00004
name: Nicotinamide adenine dinucleotide - reduced

metaM ach e
is: HMDB00895
constant: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
boundary condition: false
is: SBO:0000247
is: CHEBI:15355
type: Species
initial amount: NaN
initial concentration: 1.0
name: acetylcholine
has only substance units: false

metaM ocde9ecoa x
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
name: 9-octadecenoylcoa
is: http://identifiers.org/pubchem.compound/5280355

metaR P45027A11m
reactant: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
product: MODEL1310110014#
reversible: false

metaR r0743
type: Reaction
is described by: ECO:0000000
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
is: SBO:0000176
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:

metaR CYTK7n
name: cytidylate kinase (CMP,UTP),nuclear
reactant: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110014#

metaR r0721
is described by: ECO:0000000
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: false
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_f90ea018_f00b_4a52_8d7d_02fdb80bf82c
type: Species
name: PLCE1
initial amount: NaN
is: Q9P212
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51196

metaR RPE
reactant: MODEL1310110014#
name: ribulose 5-phosphate 3-epimerase
modifier: MODEL1310110014#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
product: MODEL1310110014#
reversible: true
is version of: http://identifiers.org/ec-code/5.1.3.1
is: SBO:0000176

metaM grdp x
name: geranyl diphosphate(3-)
initial concentration: 1.0
is: CHEBI:58057
is: HMDB01285
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false

metaM cit m
name: Citrate
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
type: Species
initial concentration: 1.0
is: HMDB00094
has only substance units: false
initial amount: NaN
is: CHEBI:16947
is: C00158
constant: false
is: SBO:0000247
boundary condition: false

metaM dchac e
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00626
name: deoxycholic acid
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C24H39O4 CHARGE: -1

metaM lthstrl r
boundary condition: false
is: HMDB01170
has only substance units: false
is: CHEBI:17168
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
name: 5alpha-cholest-7-en-3beta-ol
constant: false

metaR r1842
modifier: MODEL1310110014#
name: Y+LAT2 Utilized transport
is: SBO:0000185
reversible: false
product: MODEL1310110014#
fast: false
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110014#_10b60be4_6e5f_443f_8db7_2d365de70426
is: SBO:0000252
has only substance units: false
is: P78330
initial concentration: NaN
constant: false
name: PSPH
boundary condition: true
initial amount: NaN
is encoded by: hsa:5723
type: Species

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaM lnlncgcoa x
is: HMDB06368
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57363
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
has only substance units: false
name: gamma-linolenoyl-CoA(4-)
initial concentration: 1.0

metaR r0744
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
is: SBO:0000176
product: MODEL1310110014#
fast: false
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
kinetic law: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_b1d5d141_bb6c_4d27_b85c_2b56b3832728
is encoded by: hsa:55163
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is: Q9NVS9
has only substance units: false
name: PNPO
initial amount: NaN
boundary condition: true

metaM omeprazole c
initial amount: NaN
constant: false
is: SBO:0000247
name: omeprazole
type: Species
is: HMDB01913
boundary condition: false
is: CHEBI:7772
notes: FORMULA: C17H19N3O3S CHARGE: 0 INCHI: InChI=1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
initial concentration: 1.0
has only substance units: false

metaR r0722
is: SBO:0000176
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
modifier: MODEL1310110014#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/4.2.3.12
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_48272d14_69ea_4247_820b_d5eca817fb5a
is encoded by: hsa:6487
constant: false
name: ST3GAL3
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR MALSO3tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reversible: true
name: Malate:sulfite antiport, mitochondrial
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_0c9fcbb4_7820_46da_83d7_afa8d4fc9222
is: SBO:0000252
type: Species
boundary condition: true
constant: false
is encoded by: hsa:80704
initial amount: NaN
initial concentration: NaN
name: SLC19A3
has only substance units: false
is: Q9BZV2

metaR AATAi
reactant: MODEL1310110014#
modifier: MODEL1310110014#
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.6.1.7
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (51166.1) or (51166.2) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 4 AUTHORS: PMID:12126930 NOTES:MM
name: 2-aminoadipate transaminase, irreversible
fast: false
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110014#_04c9a753_3cbc_4ab9_bd34_9302e3229200
is: Q548A7
initial amount: NaN
is encoded by: hsa:65010
boundary condition: true
constant: false
has only substance units: false
type: Species
name: SLC26A6
initial concentration: NaN
is: SBO:0000252

metaR NACHEX1ly
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110014#
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110014#
reactant: MODEL1310110014#
reversible: false

metaR r2196
kinetic law: MODEL1310110014#
fast: false
product: MODEL1310110014#
reactant: MODEL1310110014#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_b2bc804f_3529_44c6_b3db_b8a073e23a02
has only substance units: false
is: P30613
constant: false
is encoded by: hsa:5313
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: PKLR
initial concentration: NaN

metaR AASAD3m
reversible: false
kinetic law: MODEL1310110014#
name: L-aminoadipate-semialdehyde dehydrogenase (NADH), mitochondrial
fast: false
reactant: MODEL1310110014#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15865210 NOTES:MM. Found under reaction synonym name: 2-aminoadipic 6-semialdehyde dehydrogenase; Evidence was from mouse with identification of good human ortholog for U26 in the mouse that catalyzes this reaction. There was NOT evidence here specific to mitochondria, though. (Nathan Price)
product: MODEL1310110014#

metaM ach c
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
name: acetylcholine
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:15355
boundary condition: false
has only substance units: false
is: HMDB00895
is: SBO:0000247
constant: false

metaR FAOXC163C142x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_ac484c37_11b5_4a1c_b18b_1dc86e42a2df
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
name: ST3GAL2
is: SBO:0000252
constant: false
is encoded by: hsa:6483
is: Q16842

metaR S6T7g
kinetic law: MODEL1310110014#
reversible: false
reactant: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
modifier: MODEL1310110014#
fast: false

metaR PYDXNtr
kinetic law: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT
type: Reaction
is: SBO:0000185
fast: false
name: pyridoxine transport via diffusion
product: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true

metaR C5DCe
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of glutaryl carnitine into the extra cellular fluid
type: Reaction

metaM uacgam c
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: HMDB00290
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:57705

metaR DCK1n
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
modifier: MODEL1310110014#
is: SBO:0000176
product: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
name: Deoxycytidine kinase, nuclear (ATP)
is version of: http://identifiers.org/ec-code/2.7.1.74

metaR S6TASE10ly
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: true
type: Reaction
kinetic law: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: galactose-6-sulfate sulfatase, lysosomal
is described by: ECO:0000000
product: MODEL1310110014#
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_457f0625_c42b_47dc_ba01_0bb21219e4de
constant: false
has only substance units: false
is encoded by: hsa:7498
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
name: XDH
is: P47989
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_73310bdd_772a_437e_ae76_76e8a5c70238
is: SBO:0000252
is encoded by: hsa:5142
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q5TEK5
boundary condition: true
type: Species
constant: false
name: PDE4B

metaR C161CRN2t
type: Reaction
reactant: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110014#
name: C161 transport into the mitochondria
kinetic law: MODEL1310110014#
is: SBO:0000185
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_81433b88_3101_4124_b881_2f10abf819a4
is: Q9NYW8
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:57786
name: RBAK
boundary condition: true
initial concentration: NaN

metaR TCHOLAt
is described by: ECO:0000269
modifier: MODEL1310110014#
is: SBO:0000185
fast: false
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (28231.1) or (6579.1) or (28234.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
type: Reaction
name: taurocholate transport via bicarbonate countertransport
reactant: MODEL1310110014#
reversible: true
kinetic law: MODEL1310110014#

metaR HGNTOR
fast: false
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
product: MODEL1310110014#
modifier: MODEL1310110014#
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.13.11.5
type: Reaction
reversible: false
is: SBO:0000176
reactant: MODEL1310110014#

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR r0463
kinetic law: MODEL1310110014#
is: SBO:0000176
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
reactant: MODEL1310110014#
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10

metaR ACACT5p
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110014#
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
reversible: false
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110014#_49a0580d_bbb9_4ed9_a468_15e36b55dad2
constant: false
has only substance units: false
name: RFK
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:55312
boundary condition: true
is: B2RDZ2
is: SBO:0000252
type: Species

metaM c10dc x
boundary condition: false
is: HMDB00651
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C17H30NO6 CHARGE: -1
has only substance units: false
name: sebacoyl carnitine
constant: false
type: Species

metaR S3TASE3ly
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: N-acetylglucosamine-3-sulfatase, lysosomal
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
reversible: true
product: MODEL1310110014#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110014#_3c1f7d5c_b63c_4d72_9c71_497018f2ed70
boundary condition: true
type: Species
is encoded by: hsa:5283
has only substance units: false
name: PIGH
is: Q14442
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN

metaM HC02180 e
initial amount: NaN
is: CHEBI:28728
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
name: thromboxane-b2
boundary condition: false
is: SBO:0000247

metaR r2194
fast: false
product: MODEL1310110014#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110014#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_metaM_galacglcgalacglcgal14acglcgalgluside_hs_g
initial amount: NaN
is: SBO:0000247
name: I-antigen
boundary condition: false
has only substance units: false
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0
constant: false
type: Species
is: CHEBI:26174
initial concentration: 1.0

metaR FUT911g
reversible: false
modifier: MODEL1310110014#
type: Reaction
name: Alpha-(1,3)-fucosyltransferase
fast: false
product: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.152
is described by: ECO:0000269
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_baf9553d_5749_450c_9479_e9a4631c128d
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4719
name: NDUFS1
initial amount: NaN
is: P28331
boundary condition: true
type: Species

metaR STRDNCCPT2
reversible: false
modifier: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
product: MODEL1310110014#
type: Reaction
fast: false
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110014#_038480a8_dfa6_41a2_949f_39fadf62e42b
initial concentration: NaN
is encoded by: hsa:4144
has only substance units: false
type: Species
constant: false
name: MAT2B:MAT2A
has part: P31153
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:27430
boundary condition: true

metaM chlstol r
has only substance units: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
initial amount: NaN
constant: false
is: CHEBI:16290
initial concentration: 1.0
type: Species
is: HMDB06842
name: 5alpha-cholesta-7,24-dien-3beta-ol
is: SBO:0000247
boundary condition: false

metaM ksii core2 pre1 g
name: keratan sulfate II biosynthesis, precursor 1
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:28067
notes: FORMULA: C33H53N3O23X CHARGE: -1
type: Species
has only substance units: false
is: SBO:0000247

metaR FAOXC103C102m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaM gal e
constant: false
has only substance units: false
is: HMDB00143
is: SBO:0000247
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0
initial amount: NaN
is: CHEBI:0
boundary condition: false
is: C00124
name: D-Galactose
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_29cc122d_04ab_4cf9_8b38_d7c8ea67d2a3
initial concentration: NaN
is encoded by: hsa:23464
constant: false
name: GCAT
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: E2QC23
type: Species

metaM xol27oh r
initial amount: NaN
initial concentration: 1.0
name: 26-hydroxycholesterol
has only substance units: false
is: CHEBI:17703
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: HMDB02103
constant: false
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_00d16a42_7114_411f_9dc9_e9a1cad1323d
initial concentration: NaN
type: Species
name: MPST
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4357
is: P25325
has only substance units: false
boundary condition: true
constant: false

metaM lnlc r
is: HMDB00673
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: linoleate
is: SBO:0000247
constant: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
is: CHEBI:30245
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_6ed7362c_ec69_437d_a6e1_2d925e90d51a
boundary condition: true
has only substance units: false
name: HPS3
constant: false
is: SBO:0000252
is: Q969F9
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:84343

http://identifiers.org/biomodels.db/MODEL1310110014#_6dfd8f06_cf6b_4aba_895d_1cb157bf65f2
constant: false
boundary condition: true
is: P05062
has only substance units: false
is: SBO:0000252
is encoded by: hsa:229
type: Species
name: ALDOB
initial concentration: NaN
initial amount: NaN

metaM 3aib D m
is: C03265
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: SBO:0000247
constant: false
initial amount: NaN
name: D-3-Amino-isobutanoate
is: HMDB02299
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species

metaR r2193
kinetic law: MODEL1310110014#
reversible: true
fast: false
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
modifier: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR STRDNCCPT1
is: SBO:0000176
product: MODEL1310110014#
name: carnitine O-palmitoyltransferase
fast: false
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000000
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

metaR LEUPHELAT2tc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR r1569
reactant: MODEL1310110014#
is described by: ECO:0000000
reversible: true
product: MODEL1310110014#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_a51f96f2_1ddd_4a64_b95f_0eeaeeef871d
has only substance units: false
is encoded by: hsa:6508
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
name: SLC4A3
type: Species

metaR KSII CORE4t
name: keratan sulfate II (core4) transport, golgi to extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110014#

metaR URCN
modifier: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
reactant: MODEL1310110014#
name: URCN
product: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.49
is: SBO:0000176
fast: false
kinetic law: MODEL1310110014#

metaR PROSTGE2t
kinetic law: MODEL1310110014#
is described by: ECO:0000269
reactant: MODEL1310110014#
modifier: MODEL1310110014#
fast: false
type: Reaction
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
is: SBO:0000185
name: prostaglandin transport via bicarbonate countertransport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_e8d0ddaf_4429_499a_885d_c17c0523ca90
is: P47895
has only substance units: false
name: ALDH1A3
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:220
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_bb8b7ce2_0959_43fb_a6b4_5c1d16223178
is encoded by: hsa:644
is: P53004
initial concentration: NaN
constant: false
is: SBO:0000252
name: BLVRA
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species

metaR RE3628M
type: Reaction
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
fast: false
product: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.3.8
name: RE3628
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110014#
is described by: ECO:0000000
modifier: MODEL1310110014#

metaM tetpent6coa c
is: SBO:0000247
type: Species
is: C16172
constant: false
boundary condition: false
has only substance units: false
name: tetracosapentaenoyl coenzyme A, n-6
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1

metaR r1568
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110014#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_906ff435_60ca_4396_a731_23d15e69ed3a
has only substance units: false
constant: false
type: Species
boundary condition: true
is: SBO:0000252
name: NEU1
initial concentration: NaN
is: Q99519
is encoded by: hsa:4758
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_151a38de_9b28_4f70_920e_00152511e6f3
is: SBO:0000252
is encoded by: hsa:23428
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q86U05
constant: false
name: SLC7A8
has only substance units: false

metaM 5homeprazole c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00259
has only substance units: false
is: CHEBI:350546
boundary condition: false
type: Species
notes: FORMULA: C17H19N3O4S CHARGE: 0
name: 5 hydroxy omeprazole

metaR r0899
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
name: Amino acid transporter ATB0+ Facilitated diffusion
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
fast: false
type: Reaction

metaR r1567
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000185
type: Reaction

metaR C16OHc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecanoylcarnitinec
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_6928ccde_0608_452c_99f8_226e380fbbbb
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is encoded by: hsa:AI656480
name: _AI656480_1_m
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_d6beeba0_259c_4547_9ca7_eadd00aeee5f
boundary condition: true
type: Species
is: Q8TDY1
name: B3GALNT1
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8706

metaM 3hbcoa m
is: HMDB01166
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
initial concentration: 1.0
is: CHEBI:57316
name: (S)-3-hydroxybutanoyl-CoA(4-)

metaM s2l2fn2m2masn g
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00868
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C90H145N6O65X CHARGE: -2
is: CHEBI:57737
type: Species
name: PA6

metaR r2199
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110014#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: MODEL1310110014#
fast: false

metaR G14T4g
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reversible: false
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
fast: false
reactant: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.22

metaM uacgam g
boundary condition: false
type: Species
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: HMDB00290
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
constant: false
has only substance units: false
is: CHEBI:57705
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM appnn e
name: (+)-alpha-pinene
initial concentration: 1.0
type: Species
notes: FORMULA: C10H16 CHARGE: 0 INCHI: InChI=1S/C10H16/c1-7-4-5-8-6-9(7)10(8,2)3/h4,8-9H,5-6H2,1-3H3/t8-,9-/m1/s1
is: HMDB06525
is: SBO:0000247
is: CHEBI:28261
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_b8abebea_e934_4358_a557_188fdff7a340
boundary condition: true
is: SBO:0000252
name: CRAT
initial amount: NaN
type: Species
is: P43155
is encoded by: hsa:1384
constant: false
initial concentration: NaN
has only substance units: false

metaR OCD11COACPT1
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_9b81bef4_f104_4174_a4f3_c8d0643420d3
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P03905
type: Species
is encoded by: hsa:4538
name: ND4
constant: false

metaM ptdcacoa c
constant: false
is: HMDB06499
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: pentadecanoyl Coenzyme A

metaR ETOHt
reactant: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110014#
is: SBO:0000185
type: Reaction
name: ethanol reversible transport
reversible: true
product: MODEL1310110014#

metaR r1566
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110014#
product: MODEL1310110014#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110014#
fast: false

metaR S6TASE16ly
type: Reaction
modifier: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110014#
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110014#
is: SBO:0000176
product: MODEL1310110014#

metaR r2198
reactant: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110014#
is: SBO:0000185
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110014#

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_954152b7_ce26_4803_ae0d_7589d252d02b
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR ASPTA
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
kinetic law: MODEL1310110014#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110014#
product: MODEL1310110014#
reversible: true
fast: false
modifier: MODEL1310110014#
name: aspartate transaminase

http://identifiers.org/biomodels.db/MODEL1310110014#_41096139_1ca9_4c5f_b48d_b21cf9c56b25
name: FECH
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:2235
is: Q7KZA3
is: SBO:0000252
initial concentration: NaN

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaR r2197
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110014#
fast: false
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000000
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110014#_559b999c_dee0_42f0_aeee_f2523266cccb
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI435857
initial concentration: NaN
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: _AI435857_1_x

metaR r1565
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110014#
fast: false
reversible: true
product: MODEL1310110014#
kinetic law: MODEL1310110014#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR ACGALtly
reversible: false
type: Reaction
fast: false
name: N-acetyl-galactosamine lysosomal efflux
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
product: MODEL1310110014#

metaM 5homeprazole e
name: 5 hydroxy omeprazole
notes: FORMULA: C17H19N3O4S CHARGE: 0
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00259
is: CHEBI:350546
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_8f6eedaa_2db6_43f2_8e9c_495e75e868cf
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3032
has only substance units: false
name: HADHB
initial concentration: NaN
is: P55084
type: Species
boundary condition: true

metaM itacon m
name: itaconate(2-)
has only substance units: false
is: CHEBI:17240
initial amount: NaN
is: HMDB02092
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_e91e71bd_d5f6_48a3_b152_67d605da9246
initial amount: NaN
boundary condition: true
is encoded by: hsa:51022
constant: false
initial concentration: NaN
name: GLRX2
type: Species
has only substance units: false
is: SBO:0000252

metaM dutp m
has only substance units: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: HMDB01191
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
name: dUTP
is: CHEBI:17625

metaM nad m
type: Species
is: SBO:0000247
name: Nicotinamide adenine dinucleotide
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3305
constant: false
has only substance units: false
is: C00003
initial concentration: 1.0
boundary condition: false
is: CHEBI:57540
is: HMDB00902

metaM HC00342 m
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
name: cis-aconitate(3-)
is: SBO:0000247
is: CHEBI:16383
constant: false

metaR FRUt4
name: D-fructose transport via sodium cotransport
fast: false
type: Reaction
product: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110014#_58464c06_1e7e_4daa_bd60_f9b5f752933d
has only substance units: false
is: P49327
initial amount: NaN
boundary condition: true
name: FASN
type: Species
constant: false
is encoded by: hsa:2194
is: SBO:0000252
initial concentration: NaN

metaM octdececrn c
has only substance units: false
notes: FORMULA: C25H47NO4 CHARGE: 0
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
is: HMDB06351
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_2cd1cf44_5f91_472e_938f_d47b9afc827d
initial amount: NaN
constant: false
is: P00441
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:6647
name: SOD1
type: Species
initial concentration: NaN

metaM ppi x
has only substance units: false
type: Species
is: HMDB00250
is: SBO:0000247
is: C00013
constant: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0
name: Diphosphate
boundary condition: false
is: CHEBI:33019
initial amount: NaN

metaM dcsptn1crn m
is: HMDB06321
constant: false
is: SBO:0000247
type: Species
name: docosa-4,7,10,13,16-pentaenoyl carnitine
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_f8fce7b3_0c47_4b13_81d3_bccfda1b0a3d
initial concentration: NaN
name: OGDHL
is encoded by: hsa:55753
initial amount: NaN
is: Q9ULD0
type: Species
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true

metaM srtn e
has only substance units: false
type: Species
is: HMDB00259
initial concentration: 1.0
name: serotonin(1+)
initial amount: NaN
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:350546

http://identifiers.org/biomodels.db/MODEL1310110014#_386778bc_34b3_4b56_bfe3_a3093e683f2c
is encoded by: hsa:4701
boundary condition: true
initial amount: NaN
constant: false
name: NDUFA7
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q6FG42

metaR PFK
reactant: MODEL1310110014#
is described by: ECO:0000304
fast: false
is: SBO:0000176
kinetic law: MODEL1310110014#
type: Reaction
modifier: MODEL1310110014#
product: MODEL1310110014#
reversible: false
name: phosphofructokinase
is version of: http://identifiers.org/ec-code/2.7.1.11
notes: GENE_ASSOCIATION: (5214.1) or (5211.2) or (5214.1 and 5211.1) or (5214.1 and 5213.1) or (5213.1) or (5214.1 and 5211.2) or (5211.1) or (5211.1 and 5213.1) or (5213.1 and 5211.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaM arachdcrn m
is: SBO:0000247
has only substance units: false
is: HMDB01322
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:57387
constant: false
name: C20:4 carnitine
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
initial concentration: 1.0

metaR ESTRONESt
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (11309.1) or (10599.1) or (53919.1) or (6579.1) or (28232.1) or (28231.1) or (28234.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
type: Reaction
modifier: MODEL1310110014#
name: estrone 3-sulfate transport via bicarbonate countertransport
product: MODEL1310110014#
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110014#
is described by: ECO:0000269

metaM pectindchac e
type: Species
initial concentration: 1.0
boundary condition: false
name: pectin-deoxycholic acid complex
constant: false
is: HMDB03402
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C2559H3549O2539 CHARGE: -1

metaR RE1516M
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reversible: true
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.3.99.13
reactant: MODEL1310110014#
is described by: ECO:0000000
kinetic law: MODEL1310110014#
name: RE1516
fast: false
type: Reaction
is: SBO:0000176

metaR FAOXC161802m
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000269
product: MODEL1310110014#
is: SBO:0000176
name: Beta oxidation fatty acid
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
fast: false
reactant: MODEL1310110014#
reversible: false

metaR S6TASE25ly
modifier: MODEL1310110014#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
name: galactose-6-sulfate sulfatase, lysosomal
reactant: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is: SBO:0000176
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR r1573
kinetic law: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110014#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
product: MODEL1310110014#
type: Reaction

metaR GGH 10FTHF7GLUe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
type: Reaction
fast: false
is: SBO:0000176
reversible: false
reactant: MODEL1310110014#
is described by: ECO:0000000
product: MODEL1310110014#
modifier: MODEL1310110014#
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110014#

metaM acgbgbside hs c
has only substance units: false
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
is: CHEBI:17411
boundary condition: false
constant: false
name: beta GalNAc globoside
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00215
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_2de3c4a3_b9c5_46ab_8829_2268b66ba8ee
constant: false
is encoded by: hsa:8704
boundary condition: true
type: Species
initial amount: NaN
is: O60909
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: B4GALT2

metaM CE4792 m
is: SBO:0000247
is: CHEBI:57923
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: 3-oxo-cis-8-tetradecenoyl-CoA
type: Species

metaM gal l
constant: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
has only substance units: false
is: CHEBI:12936
name: D-galactose
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00143

metaR r0456
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.1.32
is: SBO:0000176
reversible: false
modifier: MODEL1310110014#

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

metaM 3hbcoa R m
has only substance units: false
boundary condition: false
is: HMDB01166
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14-,18-,19-,20+,24-/m1/s1
constant: false
is: CHEBI:57315
name: (R)-3-hydroxybutanoyl-CoA(4-)

metaR r1574
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110014#
fast: false
is: SBO:0000185
reactant: MODEL1310110014#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM hspg e
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: heparan sulfate proteoglycan
is: HMDB02259
is: CHEBI:32366
notes: FORMULA: C79H113N5O101S12X CHARGE: -13

metaR NACHEXA20ly
reversible: false
kinetic law: MODEL1310110014#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
product: MODEL1310110014#
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110014#
is: SBO:0000176
type: Reaction
name: beta-N-acetylhexosaminidase A, lysosomal

metaR S6TASE1ly
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110014#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_ae6f91b9_6227_41db_b365_b16ca0491067
is encoded by: hsa:108
initial concentration: NaN
constant: false
is: Q71UM8
is: SBO:0000252
name: ADCY2
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_348c75a3_7b47_45aa_9b3c_2c03bc7d4d94
constant: false
has only substance units: false
is encoded by: hsa:114799
initial amount: NaN
is: SBO:0000252
is: Q5FWF5
initial concentration: NaN
boundary condition: true
type: Species
name: ESCO1

metaR r2379
reversible: true
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
reactant: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110014#

metaR GGH 10FTHF5GLUe
is described by: ECO:0000000
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
product: MODEL1310110014#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110014#
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110014#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_d38fb872_e939_4280_a9f5_69a18e5a6935
is encoded by: hsa:2593
constant: false
initial concentration: NaN
is: Q14353
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
name: GAMT
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_1eca73d1_fc53_42c4_bf85_55b2772b3f4b
constant: false
is: Q9NVE7
name: PANK4
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:55229
has only substance units: false

metaR r1575
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM dudp m
initial concentration: 1.0
initial amount: NaN
type: Species
name: dUDP(3-)
is: CHEBI:60471
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB01000
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346

metaR GALACGLCGALGBSIDEtg
reversible: true
name: galacglcgalgbside hs intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
is: SBO:0000185
product: MODEL1310110014#
is described by: ECO:0000000
fast: false

metaR RE3626M
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is: SBO:0000176
reactant: MODEL1310110014#
name: RE3626
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
reversible: false
fast: false
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_15749824_90a5_47c7_921c_f198876c2bc6
initial concentration: NaN
name: FTCD
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:10841
is: SBO:0000252

metaR RE2660N
type: Reaction
name: RE2660
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/4.2.1.96
reversible: true
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110014#

metaM CE4876 r
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
type: Species
has only substance units: false
is: CHEBI:57923
initial concentration: 1.0
name: delta12-Prostaglandin J2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_bd3ea337_0ce5_404d_b648_ed42607ae2f0
boundary condition: true
type: Species
is: O75874
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: IDH1
is encoded by: hsa:3417
initial concentration: NaN

metaM naglc2p L c
constant: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C1160H1898N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
has only substance units: false
is: CHEBI:18278
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human liver homolog
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_bbaca4d7_9a4e_4c3e_a0c6_676888fd1c62
has only substance units: false
is encoded by: hsa:29929
name: ALG6
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
is: Q9Y672

metaR r1576
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110014#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_801e06a5_473f_46d4_b5ae_389636fa2a4e
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
name: PDE1A
type: Species
is encoded by: hsa:5136
is: Q9Y633
has only substance units: false
initial concentration: NaN

metaM nadh m
is: http://identifiers.org/pubchem.compound/3306
is: CHEBI:57945
is: HMDB01487
is: SBO:0000247
type: Species
initial amount: NaN
name: Nicotinamide adenine dinucleotide - reduced
is: C00004
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false

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constant: false
is: SBO:0000252
name: SUCLA2
is encoded by: hsa:8803
is: E5KS60
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_128b8a1f_dc7e_40e3_9721_ba9f8319800b
type: Species
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: A7E2E5
initial concentration: NaN
is: SBO:0000252
name: PDE3B
is encoded by: hsa:5140

metaM lnlncg c
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is: HMDB03073
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:32391
name: gamma-linolenate
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_13757d0d_b01c_41cd_9809_8ece9b5d8957
is encoded by: hsa:2720
has part: P16278
is encoded by: hsa:2588
is encoded by: hsa:5476
has only substance units: false
has part: P10619
has part: Q99519
is: SBO:0000297
name: GALNS:GLB1:NEU1:CTSA
initial amount: NaN
type: Species
constant: false
has part: P34059
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4758

metaM hexdectecoa x
is: SBO:0000247
has only substance units: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
constant: false
is: HMDB02288
name: 2,4,7,10-hexadecatetraenoylcoa
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_3bd15eab_fbc2_4063_8a0a_2b0409dc321e
type: Species
constant: false
is encoded by: hsa:230
is: SBO:0000252
has only substance units: false
is: P09972
name: ALDOC
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaM dectricoa x
name: 2,4,7-decatrienoylcoa
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
constant: false
type: Species
has only substance units: false

metaR VLCS2r
modifier: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is described by: ECO:0000304
reversible: false
name: Very-long-chain-fatty-acid-CoA ligase
is: SBO:0000176
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110014#
reactant: MODEL1310110014#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_6db822c5_5c9c_4a15_9dbd_21b68297163d
initial amount: NaN
is: SBO:0000252
name: PSAT1
has only substance units: false
is encoded by: hsa:29968
boundary condition: true
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_b75236f0_dec2_4238_89b4_9d7ddad87ed8
boundary condition: true
is encoded by: hsa:5286
is: O00443
has only substance units: false
type: Species
is: SBO:0000252
constant: false
name: PIK3C2A
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_0bd06ed5_84d4_490b_ae80_c30b774565ba
type: Species
is: O15427
boundary condition: true
initial amount: NaN
is encoded by: hsa:9123
has only substance units: false
name: SLC16A3
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_93e8eb60_826f_499d_86df_c9019849f7b2
initial amount: NaN
is encoded by: hsa:23057
is: SBO:0000252
has only substance units: false
constant: false
type: Species
name: NMNAT2
boundary condition: true
initial concentration: NaN

metaR CYSO
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
is described by: ECO:0000269
product: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/1.13.11.20
name: cysteine oxidase
reversible: false
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110014#_9a1f335a_d294_4d12_bb32_29c508926ece
name: ACOT8
boundary condition: true
is: O14734
is encoded by: hsa:10005
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
initial concentration: NaN

metaM nadph x
type: Species
is: SBO:0000247
is: C00005
boundary condition: false
is: HMDB00221
constant: false
is: CHEBI:57783
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate - reduced
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005

metaM CE2418 m
boundary condition: false
is: CHEBI:28387
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
type: Species
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB11123

metaM acgbgbside hs g
is: SBO:0000247
boundary condition: false
name: beta GalNAc globoside
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00215
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
is: CHEBI:17411
type: Species
has only substance units: false

metaR EX glygn4 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_79ba4fdb_4fb0_48c9_83f3_2768d088944d
initial amount: NaN
boundary condition: true
name: AGPAT3
is encoded by: hsa:56894
has only substance units: false
type: Species
is: SBO:0000252
is: Q9NRZ7
constant: false
initial concentration: NaN

metaR FACOAL191
is: SBO:0000176
name: fatty-acid--CoA ligase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:11591435 NOTES:current models suggest COAL activity occurs on outer peroxisomal membrane NJ
reversible: false
fast: false
modifier: MODEL1310110014#
product: MODEL1310110014#

metaR ABO5g
modifier: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.37
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
is: SBO:0000176
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110014#_9ad2af3b_4089_42be_a6d0_cce974ed8157
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:AL050025
boundary condition: true
has only substance units: false
name: _AL050025_1_c

metaR 3AIBtm
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.6.1.19
reversible: false
reactant: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
name: 3-amino-isobutyrate transport, mitochondrial
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaM hs deg24 l
is: CHEBI:16126
notes: FORMULA: C31H50NO26 CHARGE: -1
is: SBO:0000247
has only substance units: false
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
name: GlcNAc-GlcA-(Gal)2-Xyl
initial amount: NaN

metaR r1570
is: SBO:0000185
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110014#
is described by: ECO:0000000
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110014#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_23197a26_0868_46ef_97f9_5a8d280e6ee8
is: Q00796
is encoded by: hsa:6652
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: SORD
boundary condition: true

metaR 3SPYRSPm
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
is: SBO:0000176
reactant: MODEL1310110014#
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial

metaR GLNtm
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
type: Reaction
product: MODEL1310110014#
fast: false
name: L-glutamine transport via electroneutral transporter
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_85a64b70_5eb3_4303_b6af_ad93c68d2ae1
initial concentration: NaN
constant: false
type: Species
is: Q9Y231
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:10690
initial amount: NaN
name: FUT9

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaM HC00718 c
name: N-methylethanolaminium phosphate(1-)
initial amount: NaN
constant: false
is: CHEBI:57781
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
initial concentration: 1.0
has only substance units: false

metaM tsul m
name: thiosulfate(2-)
has only substance units: false
type: Species
is: HMDB00257
constant: false
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: CHEBI:16094
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_82479f43_ba20_4a8c_a6d2_645ecdce03e2
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
name: MTHFR
is: Q59GJ6
is encoded by: hsa:4524
is: SBO:0000252

metaR EX retfa LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid retinol exchange
type: Reaction

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaM hdd2coa x
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: SBO:0000247
is: HMDB03945
name: (E)-hexadec-2-enoyl-CoA(4-)
is: CHEBI:61526
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_bd1ec5d5_74a1_4fd4_8ef4_0d5f3e4122c9
is: P48448
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:222
constant: false
name: ALDH3B2
is: SBO:0000252
initial amount: NaN
type: Species

metaM nadh r
initial amount: NaN
boundary condition: false
is: HMDB01487
type: Species
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
name: NADH(2-)
is: CHEBI:57945

metaR r1571
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_9ce2f1fd_5d3a_41da_8805_16005bcf166f
initial amount: NaN
is encoded by: hsa:6543
is: Q9UPR5
is: SBO:0000252
type: Species
has only substance units: false
name: SLC8A2
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_d461ebd9_87fe_42a5_9bf2_e38612db61b9
has only substance units: false
initial concentration: NaN
name: BCKDHB
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:594
is: P21953

http://identifiers.org/biomodels.db/MODEL1310110014#_2413cf07_0295_4d13_ab47_ef4740ea984c
is encoded by: hsa:2590
has only substance units: false
is: SBO:0000252
name: GALNT2
is: Q10471
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false

metaR EX ddece1crn
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dodecenoyl carnitine
type: Reaction

metaM udpglcur c
boundary condition: false
name: UDP-D-glucuronate
is: C00167
constant: false
is: SBO:0000247
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: HMDB00935
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:58052

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR FAOXC121C101m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:1-->C10:1)m
type: Reaction

metaM 3thexddcoa m
is: SBO:0000247
name: 3-hydroxy trans7,10-hexadecadienoylcoa
constant: false
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C37H58N7O18P3S CHARGE: -4
is: HMDB02014
initial concentration: 1.0

metaR FAOXC184C163m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C18:4-->C16:3)m
type: Reaction

metaM ksi deg26 l
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
is: CHEBI:58343
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00061
name: keratan sulfate I, degradation product 26
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_169fe706_37f5_467b_aa65_539a9797481c
initial concentration: NaN
is encoded by: hsa:11001
boundary condition: true
constant: false
is: O14975
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
name: SLC27A2

metaM h2o x
has only substance units: false
is: C00001
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB02111
is: CHEBI:15377
name: H2O
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

metaM HC02180 c
is: CHEBI:28728
initial concentration: 1.0
name: thromboxane-b2
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_c06e20ca_33d6_435f_a987_667c50b88da9
is encoded by: hsa:3295
constant: false
is: SBO:0000252
is: E9PB82
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
name: HSD17B4

http://identifiers.org/biomodels.db/MODEL1310110014#_eb7a1609_14f1_4cb3_b950_b874a6b173ef
is: Q16222
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
name: UAP1
is encoded by: hsa:6675
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_70318872_21a3_4aea_a6ba_07e3dc812989
constant: false
has only substance units: false
is encoded by: hsa:5151
type: Species
initial amount: NaN
name: PDE8A
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR RE3002X
is described by: ECO:0000000
modifier: MODEL1310110014#
type: Reaction
name: RE3002
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/5.3.3.8
product: MODEL1310110014#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_f02294a9_4192_4930_accc_d01cfb8dd183
initial amount: NaN
boundary condition: true
type: Species
is: Q9HC21
name: SLC25A19
is: SBO:0000252
has only substance units: false
is encoded by: hsa:60386
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_f54bf469_a332_4f3a_bd38_f2d5d209ee54
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:210
name: ALAD
initial concentration: NaN
boundary condition: true
is: P13716
type: Species

metaR r2372
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
type: Reaction
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000

metaR r0726
is: SBO:0000176
reactant: MODEL1310110014#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.33
is described by: ECO:0000000
reversible: true
fast: false

metaM hspg l
type: Species
is: CHEBI:17899
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
boundary condition: false
initial concentration: 1.0
name: heparan sulfate proteoglycan
is: SBO:0000247
is: HMDB01993

metaM nadh x
is: HMDB01487
name: Nicotinamide adenine dinucleotide - reduced
is: SBO:0000247
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3306
boundary condition: false
is: CHEBI:57945
is: C00004
type: Species
initial amount: NaN
initial concentration: 1.0

metaM etoh e
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: ethanol
is: CHEBI:16236
is: HMDB00108
initial concentration: 1.0
constant: false
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469

metaR LPS4e
name: phospholipase
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.4
is: SBO:0000176
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (50487.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10713052 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
is described by: ECO:0000000
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: false
product: MODEL1310110014#

metaM ahcys m
has only substance units: false
initial concentration: 1.0
is: C00021
initial amount: NaN
constant: false
is: CHEBI:16680
is: HMDB00939
boundary condition: false
name: S-Adenosyl-L-homocysteine
type: Species
is: SBO:0000247
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021

metaR RPI
is version of: http://identifiers.org/ec-code/5.3.1.6
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#
fast: false
modifier: MODEL1310110014#
is described by: ECO:0000000
reversible: true
name: ribose-5-phosphate isomerase
is: SBO:0000176
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
type: Reaction

metaM dc2coa m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
initial amount: NaN
name: trans-Dec-2-enoyl-CoA
initial concentration: 1.0
is: CHEBI:61406
has only substance units: false
constant: false
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_45f0ec63_1a0a_4f54_a7b6_0392a52ade8c
initial concentration: NaN
type: Species
is encoded by: hsa:6476
constant: false
name: SI
has only substance units: false
is: P14410
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR r0747
kinetic law: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110014#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110014#
reversible: true
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
product: MODEL1310110014#

metaR r2371
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110014#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
product: MODEL1310110014#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110014#
fast: false

metaM cyan m
is: CHEBI:18407
type: Species
is: HMDB02084
name: hydrogen cyanide
has only substance units: false
boundary condition: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN

metaR q10tm
reactant: MODEL1310110014#
name: transport of ubiquinone into mitochondria
type: Reaction
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110014#
reversible: true
is: SBO:0000185

metaM emgacpail hs r
boundary condition: false
is: SBO:0000247
notes: FORMULA: C39H74N2O22P2FULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
is: CHEBI:16038
constant: false
has only substance units: false
initial amount: NaN
name: phosphoethanolaminyl-mannosyl-glucosylaminyl-acylphosphatidylinositol (H5)
type: Species

metaM acgbgbside hs l
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
type: Species
initial amount: NaN
is: HMDB00215
has only substance units: false
is: SBO:0000247
is: CHEBI:17411
boundary condition: false
initial concentration: 1.0
constant: false
name: beta GalNAc globoside

metaM 3thexddcoa c
has only substance units: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4
is: HMDB02014
name: 3-hydroxy trans7,10-hexadecadienoylcoa
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN

metaR PECDCHe
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of pectins with deoxycholic acid in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR RE1804M
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reversible: true
product: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
name: RE1804
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_7e5b5d0c_0e15_4fc2_bf76_c5c700891658
has only substance units: false
name: UCK2
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:7371
type: Species
boundary condition: true
is: Q9BZX2
initial concentration: NaN

metaR SERtp
type: Reaction
product: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
reversible: true
reactant: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:10347152 NOTES:MM
name: L-serine transport, peroxisomal
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110014#_11c4b3b2_e985_4b53_b3e7_0b0c5418020e
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:8310
name: ACOX3
initial concentration: NaN
is: SBO:0000252
constant: false
is: O15254

metaR PEt
fast: false
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
name: phosphatidylethanolamine transport
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000185
reversible: true

metaR NACHEXA13ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110014#
is described by: ECO:0000000
fast: false
product: MODEL1310110014#
type: Reaction
name: beta-N-acetylhexosaminidase A, lysosomal
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000176

metaR FAOXTC182TC162m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C18:2-->C16:2)m
type: Reaction

metaM hexdectecoa m
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: 2,4,7,10-hexadecatetraenoylcoa
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB02288
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
constant: false

metaR EX adrn LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adrenic acid exchange
type: Reaction

metaR LEUKTRD4t
reversible: true
name: leukotriene D4 transport
is: SBO:0000185
reactant: MODEL1310110014#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
product: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#

metaR r0724
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
modifier: MODEL1310110014#
fast: false
product: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.33

metaR FAOXC18480m
reactant: MODEL1310110014#
product: MODEL1310110014#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of fatty acid
is described by: ECO:0000000
modifier: MODEL1310110014#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110014#

metaR r2374
product: MODEL1310110014#
fast: false
reactant: MODEL1310110014#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110014#
is described by: ECO:0000000
reversible: true

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_f2559129_e629_4f53_bd9e_8983595b10cf
type: Species
is: B3KWF4
initial amount: NaN
constant: false
is: SBO:0000252
name: GALNT11
boundary condition: true
is encoded by: hsa:63917
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_e6f81527_ccce_44a5_b772_f18e2cb8dbf4
initial concentration: NaN
name: PDHX
type: Species
has only substance units: false
boundary condition: true
is: O00330
is: SBO:0000252
is encoded by: hsa:8050
initial amount: NaN
constant: false

metaR RE3421R
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
reversible: true
is: SBO:0000176
product: MODEL1310110014#
name: RE3421
fast: false
kinetic law: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#

metaM dcsptn1crn c
boundary condition: false
initial amount: NaN
constant: false
name: docosa-4,7,10,13,16-pentaenoyl carnitine
type: Species
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
is: HMDB06321
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM 2decdicoa x
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
name: 2,7-decadienoylcoa
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_efa1bdee_ca44_41ea_a313_039e41bc8e82
constant: false
has only substance units: false
initial concentration: NaN
name: _T83654_1_e
is encoded by: hsa:T83654
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species

metaM tetpent6 e
name: tetracosapentaenoic acid, n-6
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB06322
initial concentration: 1.0
type: Species
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-

http://identifiers.org/biomodels.db/MODEL1310110014#_1bcdb177_6649_4dbf_a217_52f1184060c3
initial amount: NaN
name: DGKD
has only substance units: false
is encoded by: hsa:8527
boundary condition: true
type: Species
is: Q16760
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_8550377d_b5ca_4ca3_b9d8_62e63730f204
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: ACOT2
is encoded by: hsa:10965
is: P49753
initial amount: NaN
constant: false

metaM estrone c
name: estrone
constant: false
is: HMDB00145
notes: FORMULA: C18H22O2 CHARGE: 0 INCHI: InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1 EHMN_ABBREVIATION: C00468
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:17263
initial amount: NaN

metaR r2373
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true
is: SBO:0000185
fast: false

metaM 3hbcoa R c
constant: false
is: SBO:0000247
is: HMDB01166
boundary condition: false
type: Species
name: (R)-3-hydroxybutanoyl-CoA(4-)
initial concentration: 1.0
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14-,18-,19-,20+,24-/m1/s1
has only substance units: false
initial amount: NaN

metaR RE3347C
fast: false
is described by: ECO:0000000
name: RE3347
reversible: true
type: Reaction
product: MODEL1310110014#
is: SBO:0000176
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
kinetic law: MODEL1310110014#

metaR r0723
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
fast: false
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.41
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110014#_22b7fabd_86f8_442c_ab96_60468196bc80
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:2712
has only substance units: false
initial amount: NaN
name: GK2
is: Q14410
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_91e49985_2318_43df_8e82_4dd97620f55a
name: TM7SF2
is: O76062
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:7108
constant: false
type: Species
has only substance units: false
is: SBO:0000252

metaR FUM
reversible: true
reactant: MODEL1310110014#
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
product: MODEL1310110014#
name: fumarase
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.2

http://identifiers.org/biomodels.db/MODEL1310110014#_d01402fe_002e_4c54_8add_0783a20362ee
has only substance units: false
type: Species
is: SBO:0000252
name: _MBOAT5_1_c
is encoded by: hsa:MBOAT5
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM arachdcrn x
is: http://identifiers.org/pubchem.compound/5462164
initial amount: NaN
is: HMDB01064
boundary condition: false
name: C20:4 carnitine
initial concentration: 1.0
type: Species
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: SBO:0000247
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_e549acde_67f1_49be_a120_c8f81c8e145c
is encoded by: hsa:D87002
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
name: _D87002_1_m
type: Species
has only substance units: false

metaR r2509
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110014#
product: MODEL1310110014#
name: Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110014#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110014#_88e5957f_2d3c_4100_ad43_2795dc3cfada
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:22978
name: NT5C2
initial concentration: NaN
has only substance units: false
constant: false
is: P49902
type: Species
boundary condition: true

metaR r2376
product: MODEL1310110014#
fast: false
reactant: MODEL1310110014#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110014#

metaR r2044
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
fast: false
reversible: false
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000185
product: MODEL1310110014#
type: Reaction

metaM e4hglu m
type: Species
initial amount: NaN
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
name: erythro-4-hydroxy-L-glutamate(1-)
constant: false
is: HMDB02273
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:6331
boundary condition: false
has only substance units: false

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_f16564da_4c5a_49b8_8715_e1711b5993e3
is encoded by: hsa:6799
initial concentration: NaN
boundary condition: true
constant: false
name: SULT1A2
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species

metaM tsul c
has only substance units: false
initial amount: NaN
is: CHEBI:16094
boundary condition: false
name: thiosulfate(2-)
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
type: Species
is: HMDB00257
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_31a64f47_94f7_4147_b989_7a29935ec17a
boundary condition: true
is encoded by: hsa:8639
type: Species
initial amount: NaN
is: Q16853
has only substance units: false
constant: false
initial concentration: NaN
name: AOC3
is: SBO:0000252

metaR TETTET6t
reactant: MODEL1310110014#
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110014#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110014#
type: Reaction

metaR CYTK12n
product: MODEL1310110014#
is described by: ECO:0000269
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,dCTP),nuclear
kinetic law: MODEL1310110014#
type: Reaction
fast: false
reactant: MODEL1310110014#
is: SBO:0000176

metaR r2508
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110014#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110014#
name: Utilized transport
product: MODEL1310110014#
type: Reaction
reversible: true

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaM 3hdeccoa m
name: 3-hydroxyhexadecenoylcoa
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
constant: false
boundary condition: false
is: HMDB02288
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0

metaM amuco c
notes: FORMULA: C6H6NO4 CHARGE: -1 INCHI: InChI=1S/C6H7NO4/c7-4(6(10)11)2-1-3-5(8)9/h1-3H,7H2,(H,8,9)(H,10,11)/p-2/b3-1+,4-2- HEPATONET_1.0_ABBREVIATION: HC00907
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB01241
initial amount: NaN
name: 2-aminomuconate(2-)
is: CHEBI:57937
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_acf62b39_68ba_49ec_b48d_83f517e7963f
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is: Q02218
name: OGDH
is encoded by: hsa:4967
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_2477ee4c_0432_4161_9a88_475f0022b1c4
constant: false
is: Q8WXF9
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: SLC2A11
is encoded by: hsa:66035

metaR r2375
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110014#
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_db4d1c2f_7768_492d_9c07_916b775e145b
is encoded by: hsa:2806
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: P00505
has only substance units: false
name: GOT2

metaR B3GNT313g
modifier: MODEL1310110014#
is described by: ECO:0000254
is: SBO:0000176
product: MODEL1310110014#
type: Reaction
reversible: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
reactant: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_35b28ed4_da30_45b8_983f_2c18fa4c15b9
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: P49247
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:22934
name: RPIA

metaR r1683
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000185
reversible: false
reactant: MODEL1310110014#
product: MODEL1310110014#

metaR FACOAL1822
fast: false
name: fatty-acid--CoA ligase
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000176
reactant: MODEL1310110014#
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110014#
type: Reaction

metaR r0729
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
reactant: MODEL1310110014#
product: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
reversible: false
is described by: ECO:0000000
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

metaR FAOXC121x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_5a9bb735_5abb_4618_8d83_580c39efea08
constant: false
is: SBO:0000252
boundary condition: true
name: HAL
is encoded by: hsa:3034
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: B4E0V8

metaR RETFAt
is described by: ECO:0000000
reversible: false
is: SBO:0000185
product: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: fatty acid retinol efflux
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

metaR r2507
reactant: MODEL1310110014#
type: Reaction
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110014#
name: Utilized transport
product: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110014#_471e07e9_269e_49bb_9394_a15ce9c867ca
name: NDUFS7
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:374291
constant: false
is: O75251
type: Species
initial amount: NaN
boundary condition: true

metaM clpnd c
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: HMDB06528
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
name: clupanodonic acid
boundary condition: false
is: SBO:0000247
is: CHEBI:53488

metaM lnlc e
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:30245
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00673
is: SBO:0000247
name: linoleate

metaR COt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
is described by: ECO:0000000
name: CO transporter via diffusion
kinetic law: MODEL1310110014#
type: Reaction
reversible: true
reactant: MODEL1310110014#
fast: false
product: MODEL1310110014#

metaR r2378
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_658b5dc8_a9e7_461a_b598_7e16ccf7d858
is encoded by: hsa:19
name: ABCA1
is: O95477
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false

metaR METt4
name: L-methionine transport in via sodium symport
reversible: false
type: Reaction
kinetic law: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958 NOTES:SAB
is described by: ECO:0000269
fast: false
modifier: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_164089fa_eb25_4a63_9400_4da7f867d3f9
is: P13196
initial concentration: NaN
has only substance units: false
is encoded by: hsa:211
name: ALAS1
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN

metaR r0728
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110014#

metaM tsul e
initial amount: NaN
is: CHEBI:16094
has only substance units: false
boundary condition: false
is: HMDB00257
constant: false
type: Species
is: SBO:0000247
name: thiosulfate(2-)
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial concentration: 1.0

metaR FACOAL1821
type: Reaction
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE1514C
modifier: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
fast: false
name: fatty-acid--CoA ligase

http://identifiers.org/biomodels.db/MODEL1310110014#_57170384_b1a4_4be0_bccf_18a3e3b00e6a
initial amount: NaN
is encoded by: hsa:2109
is encoded by: hsa:2108
initial concentration: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000297
has part: P13804
name: ETFA:ETFB

metaM gdpmann c
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB01163
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
initial amount: NaN
name: GDP-alpha-D-mannose(2-)
has only substance units: false
is: CHEBI:57527

metaM dump c
initial concentration: 1.0
constant: false
is: CHEBI:246422
has only substance units: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
name: dUMP
is: C00365
type: Species
boundary condition: false
is: HMDB01409
is: SBO:0000247
initial amount: NaN

metaM nadph r
is: C00005
is: HMDB00221
has only substance units: false
boundary condition: false
type: Species
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial amount: NaN
is: CHEBI:57783
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: SBO:0000247
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_24bebb79_ca93_438c_a357_282d646c5fbd
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:65263
name: PYCRL
constant: false
has only substance units: false
is: Q53H96
is: SBO:0000252
boundary condition: true

metaR GLUTCOAACBP
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of glutaryl-CoA(5-) from mitochondria into cytosol
type: Reaction

metaR FAOXC12DCTc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dodecanedioyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_82f6cec4_8af5_4bad_bdf8_05b1911992ca
is encoded by: hsa:AI934540
type: Species
has only substance units: false
is: SBO:0000252
name: _AI934540_1_c
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN

metaR r2506
product: MODEL1310110014#
reversible: true
kinetic law: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
name: Utilized transport
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_5f222f66_08e8_451e_ab0f_d10d0711664f
initial concentration: NaN
name: GPX4
is: P36969
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:2879
is: SBO:0000252
constant: false
type: Species

metaM mpdol L c
has only substance units: false
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human liver homolog
is: SBO:0000247
is: CHEBI:18396
notes: FORMULA: C1300H2128N20O220P20 CHARGE: -20 INCHI: InChI=1S/C47H82N2O22P2/c1-26(2)13-9-14-27(3)15-10-16-28(4)17-11-18-29(5)19-12-20-30(6)21-22-64-72(60,61)71-73(62,63)70-46-37(49-32(8)54)40(57)43(35(25-52)67-46)68-45-36(48-31(7)53)39(56)44(34(24-51)66-45)69-47-42(59)41(58)38(55)33(23-50)65-47/h13,15,17,19,30,33-47,50-52,55-59H,9-12,14,16,18,20-25H2,1-8H3,(H,48,53)(H,49,54)(H,60,61)(H,62,63)/b27-15+,28-17+,29-19+/t30?,33-,34-,35-,36-,37-,38-,39-,40-,41+,42+,43-,44-,45+,46-,47+/m1/s1
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_9f00065c_bb28_4998_9fa5_1922b140bfbb
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:80055
name: PGAP1
type: Species
has only substance units: false
initial amount: NaN
is: Q75T13
boundary condition: true

metaR r0727
is described by: ECO:0000000
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110014#
reversible: false
kinetic law: MODEL1310110014#
is: SBO:0000176
fast: false
reactant: MODEL1310110014#
type: Reaction

metaR r0191
reversible: false
reactant: MODEL1310110014#
is described by: ECO:0000000
fast: false
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
type: Reaction
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.24

metaR r2377
kinetic law: MODEL1310110014#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaR B MANNASEly
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
name: beta-mannosidase, lysosomal
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.25
is described by: ECO:0000000
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110014#_9cfe6f1b_dfdd_4cdd_b3d6_97786fbb55d8
initial amount: NaN
is encoded by: hsa:26266
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q9UKG4
name: SLC13A4
initial concentration: NaN
type: Species

metaR FAOXC143C123m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_868446fc_51f2_475f_bb51_884bfbea777a
is: SBO:0000252
is: B7Z1F5
has only substance units: false
is encoded by: hsa:1558
type: Species
boundary condition: true
initial amount: NaN
constant: false
name: CYP2C8
initial concentration: NaN

metaM lnlc c
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:30245
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00673
name: linoleate
is: SBO:0000247

metaM 3odcoa x
has only substance units: false
is: HMDB03939
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
is: SBO:0000247
boundary condition: false
constant: false
type: Species
name: 3-Oxodecanoyl-CoA
is: CHEBI:28528
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB01659
initial amount: NaN
is: CHEBI:15347
name: Type IIIAb
constant: false
boundary condition: false
type: Species
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0

metaR DM dctp m
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dCTP demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_e2d4a124_c8c8_4901_87a0_61e6e20be206
initial amount: NaN
type: Species
boundary condition: true
name: SLC8A3
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:6547
has only substance units: false

metaM ksi deg23 l
has only substance units: false
is: CHEBI:12936
type: Species
constant: false
is: SBO:0000247
is: HMDB00143
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
initial amount: NaN
name: keratan sulfate I, degradation product 23

http://identifiers.org/biomodels.db/MODEL1310110014#_aeb6dcb2_6d24_457b_8779_e5a3c5336bfb
boundary condition: true
is: SBO:0000252
constant: false
is: A4D0W4
has only substance units: false
name: AASS
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:10157

metaR SPTix
type: Reaction
product: MODEL1310110014#
fast: false
modifier: MODEL1310110014#
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.44
reactant: MODEL1310110014#
is described by: ECO:0000269
kinetic law: MODEL1310110014#
name: serine-pyruvate aminotransferase (irreversible), peroxisomal
notes: GENE_ASSOCIATION: (189.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:10960483,PMID:9783918 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110014#_ef47ac2a_7cd4_42b7_aef8_6732d171d9c9
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:6482
constant: false
name: ST3GAL1
initial concentration: NaN

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_f0abe437_3e01_4ace_84e4_6ec408db60d2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4594
is: P22033
constant: false
name: MUT
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true

metaM h2o e
is: C00001
is: SBO:0000247
name: H2O
type: Species
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
is: HMDB02111
is: CHEBI:15377
has only substance units: false
initial amount: NaN
boundary condition: false

metaR FAOXC226C227m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

metaM cyan e
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: SBO:0000247
type: Species
name: hydrogen cyanide
has only substance units: false
constant: false
is: CHEBI:18407
is: HMDB02084

metaR r0181
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110014#
fast: false
type: Reaction
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
is: SBO:0000176
kinetic law: MODEL1310110014#
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_1b437d79_b2e1_407a_b88e_9de9c16d41f7
constant: false
is encoded by: hsa:AI824319
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: _AI824319_1_r
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_bec7f58e_572f_454c_9c2a_0661a72d177c
name: _728226_1_m
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:728226
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false

metaR r0730
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: false
reactant: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
product: MODEL1310110014#
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_b545ef75_fc4d_48fa_aed3_9b0dedc9ece1
has only substance units: false
boundary condition: true
initial amount: NaN
name: HPD
constant: false
is: SBO:0000252
initial concentration: NaN
is: B3KQ63
is encoded by: hsa:3242
type: Species

metaM h2o g
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
is: HMDB02111
is: CHEBI:15377
initial amount: NaN
has only substance units: false
name: water
is: SBO:0000247

metaR EHGLAT2m
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
reactant: MODEL1310110014#
reversible: false
kinetic law: MODEL1310110014#
product: MODEL1310110014#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000304
modifier: MODEL1310110014#
type: Reaction

metaR r0752
is version of: http://identifiers.org/ec-code/2.3.1.16
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
modifier: MODEL1310110014#
reversible: true
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
product: MODEL1310110014#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110014#_b0f5cf7e_d1ad_4d8f_8679_5c3ba42d0803
boundary condition: true
is: SBO:0000252
name: HLCS
is: P50747
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:3141

metaM gbside hs e
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
is: CHEBI:18259
has only substance units: false
type: Species
name: globoside

http://identifiers.org/biomodels.db/MODEL1310110014#_4e212c94_7315_44e3_be29_655541ceced3
initial concentration: NaN
type: Species
boundary condition: true
constant: false
name: _AI285872_1_c
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI285872
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_c33af4af_ef06_4964_997e_a05cc67b79e2
initial concentration: NaN
name: SLC26A3
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:1811
is: P40879
is: SBO:0000252
has only substance units: false
constant: false

metaR r2052
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110014#
reversible: false
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000185
modifier: MODEL1310110014#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_5615a339_4d3d_4373_8284_6c3e5dd0f9af
name: _BG035985_1_c
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:BG035985
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_728f5038_3cba_4c9b_9937_b751661bee67
name: NDUFB6
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:4712
initial concentration: NaN
is: O95139

metaR S3TASE2ly
reversible: true
product: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
name: N-acetylglucosamine-3-sulfatase, lysosomal

metaM acgal1p c
constant: false
type: Species
initial concentration: 1.0
is: HMDB06480
has only substance units: false
is: SBO:0000247
name: N-Acetyl-D-galactosamine 1-phosphate
boundary condition: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
initial amount: NaN
is: CHEBI:55404

metaR FAOXC8C6x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)x
type: Reaction

metaM nadph m
initial concentration: 1.0
is: C00005
is: SBO:0000247
is: HMDB00221
constant: false
is: CHEBI:57783
name: Nicotinamide adenine dinucleotide phosphate - reduced
has only substance units: false
boundary condition: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial amount: NaN
type: Species

metaR GLNS
is: SBO:0000176
fast: false
name: glutamine synthetase
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.15
type: Reaction
modifier: MODEL1310110014#
is described by: ECO:0000254
product: MODEL1310110014#
reactant: MODEL1310110014#

metaM etfrd m
boundary condition: false
type: Species
notes: FORMULA: RH2 CHARGE: 0
constant: false
name: Electron transfer flavoprotein reduced
is: SBO:0000247
initial amount: NaN
is: HMDB00145
is: CHEBI:17263
initial concentration: 1.0
has only substance units: false

metaM clpnd e
name: clupanodonic acid
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
constant: false
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: HMDB06528
initial amount: NaN
is: CHEBI:53488

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaR r0753
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
product: MODEL1310110014#
fast: false
modifier: MODEL1310110014#
reversible: true

metaR FBP26
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.3.11
type: Reaction
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.1.105
fast: false
notes: GENE_ASSOCIATION: (2203.1) or (5210.1) or (5207.1) or (5209.1) or (5208.1) or (8789.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 3.1.3.46 Confidence Level: 0 AUTHORS: NOTES:IF
is described by: ECO:0000000
reversible: false
is: SBO:0000176
name: Fructose-2,6-bisphosphate 2-phosphatase
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#

metaM C02470 c
initial concentration: 1.0
is: HMDB00881
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
type: Species
name: Xanthurenic acid
has only substance units: false
is: C02470
is: http://identifiers.org/pubchem.compound/5485

metaM hexe3coa m
initial amount: NaN
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB06522
type: Species
name: 3-hexenoylcoa
initial concentration: 1.0

metaM 3hpp m
constant: false
initial concentration: 1.0
name: 3-hydroxypropionate
has only substance units: false
initial amount: NaN
is: CHEBI:16510
type: Species
boundary condition: false
is: HMDB00700
is: SBO:0000247
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013

metaM h2o c
name: H2O
is: C00001
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:3303
has only substance units: false
constant: false
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_13c92a8c_10e3_4b94_aad6_f7305d799b5e
is: SBO:0000252
constant: false
initial concentration: NaN
name: AK4
is encoded by: hsa:205
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species

metaR L LACDcm
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
reversible: false
type: Reaction
product: MODEL1310110014#
name: L-Lactate dehydrogenase, cytosolic/mitochondrial
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: (124637.1) SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:18831974 NOTES:NCD/TDV. This reaction exists in yeast, but no evidence could be found this exists in humans. However, there may be intramitochondrial lactate dehydrogenase and lactate transport into mitochondria

http://identifiers.org/biomodels.db/MODEL1310110014#_b49cec94_8b6b_4974_8e6e_a3708de418bb
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: SLC17A4
constant: false
is encoded by: hsa:10050
is: Q9Y2C5
boundary condition: true
initial amount: NaN
type: Species

metaM ksi pre35 g
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
name: keratan sulfate I biosynthesis, precursor 35
is: SBO:0000247
type: Species
is: CHEBI:28067
has only substance units: false
initial concentration: 1.0

metaM cyan c
is: HMDB02084
type: Species
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: hydrogen cyanide
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:18407

metaR r1833
reversible: false
product: MODEL1310110014#
type: Reaction
fast: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110014#_146505bd_dceb_4b77_b7bb_284fa1325a3f
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: ARG1
boundary condition: true
is: SBO:0000252
is: P05089
is encoded by: hsa:383

metaM 3hdececrn c
is: HMDB02014
initial amount: NaN
constant: false
name: 3-hydroxyhexadecenoylcarnitine
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C23H43NO5 CHARGE: 0
type: Species

metaM ksi deg7 l
notes: FORMULA: C210H337N15O181S10 CHARGE: -10
is: CHEBI:16953
type: Species
constant: false
name: keratan sulfate I, degradation product 7
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00812

http://identifiers.org/biomodels.db/MODEL1310110014#_fd20ac59_201c_4e9e_9bb3_73d6819d9f1d
initial amount: NaN
name: _M68895_1_c
is encoded by: hsa:M68895
boundary condition: true
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN

metaM 3hdececrn e
initial amount: NaN
notes: FORMULA: C23H43NO5 CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: HMDB02068
is: SBO:0000247
has only substance units: false
name: 3-hydroxyhexadecenoylcarnitine
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_e110440a_5771_4dcb_89a9_f8c9cd2d6808
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3615
is: SBO:0000252
name: IMPDH2
is: P12268
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_ddd32c9b_c616_4326_b41b_7b3fa8bea126
initial amount: NaN
is encoded by: hsa:2799
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q7Z3X3
name: GNS
constant: false

metaM eicostetcrn m
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57312
type: Species
has only substance units: false
is: HMDB01356
is: SBO:0000247
initial amount: NaN
name: Eicosatetranoyl carnitine
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1

metaM gbside hs g
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:18259
type: Species
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
has only substance units: false
name: globoside
initial amount: NaN

metaR r0754
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_cb6c4567_d9b5_4975_97eb_152e169f4c47
is encoded by: hsa:2194
is: P49327
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
name: FASN

metaR FACOAL140i
type: Reaction
reversible: false
fast: false
name: fatty-acid--CoA ligase (tetradecanoate)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
product: MODEL1310110014#

metaR FAOXC184C163x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:3)x
type: Reaction

metaR PYAM5POr
modifier: MODEL1310110014#
is: SBO:0000176
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:NCD IT
product: MODEL1310110014#
reversible: true
is version of: http://identifiers.org/ec-code/1.4.3.5
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110014#
name: pyridoxamine 5'-phosphate oxidase

metaM Lpipecol x
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:30913
is: HMDB00716
has only substance units: false
initial amount: NaN
name: L-pipecolic acid

http://identifiers.org/biomodels.db/MODEL1310110014#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_g
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: Type IIIAb
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0
boundary condition: false
is: CHEBI:61648
initial concentration: 1.0

metaM C02470 e
initial amount: NaN
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
boundary condition: false
is: C02470
is: http://identifiers.org/pubchem.compound/5485
initial concentration: 1.0
is: HMDB00881
has only substance units: false
constant: false
type: Species
is: SBO:0000247
name: Xanthurenic acid

metaR r0733
reversible: false
fast: false
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110014#
is: SBO:0000176
modifier: MODEL1310110014#
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.5.1.12
type: Reaction
is described by: ECO:0000000

metaM ocdca c
name: stearate
has only substance units: false
is: HMDB00827
boundary condition: false
type: Species
constant: false
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:25629
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_74ebefe7_86a5_4bf6_8515_c72ec51dc6d3
constant: false
name: AK2
is: P54819
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:204
initial concentration: NaN
is: SBO:0000252

metaM dodecanac x
is: HMDB00623
initial amount: NaN
boundary condition: false
name: Dodecanedioic acid
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C12H20O4 CHARGE: -2
is: SBO:0000247

metaR AG13T3g
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
fast: false
product: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: false
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110014#
type: Reaction
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaR r0755
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110014#
fast: false
reactant: MODEL1310110014#
is: SBO:0000176
kinetic law: MODEL1310110014#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_6b274a3a_1812_4fce_8f93_96532291d82c
is encoded by: hsa:4329
name: ALDH6A1
is: SBO:0000252
initial amount: NaN
type: Species
is: Q02252
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false

metaR CYSGLUexR
type: Reaction
name: L-cysteine/L-glutamine reversible exchanger
fast: false
reactant: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000304
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_8f9b45ab_e007_4e38_92fa_839487d10a40
constant: false
has only substance units: false
type: Species
is encoded by: hsa:6713
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: SQLE
is: Q5HYI4
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_47827220_87c7_4c37_9184_b8e103ae073b
is: SBO:0000252
type: Species
is encoded by: hsa:206358
boundary condition: true
has only substance units: false
is: Q1LZ56
constant: false
initial concentration: NaN
name: SLC36A1
initial amount: NaN

metaR TETPENT6t
name: fatty acid transport via diffusion
is: SBO:0000185
reversible: true
product: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
is described by: ECO:0000000
type: Reaction

metaM dec24dicoa x
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
name: 2,4-decadienoylcoa
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: HMDB01168

http://identifiers.org/biomodels.db/MODEL1310110014#_2d6f99b2_9fbc_40c8_81e5_4d09872e2c8f
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1371
boundary condition: true
constant: false
is: P36551
name: CPOX
type: Species
is: SBO:0000252

metaR r0734
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000176
kinetic law: MODEL1310110014#
reversible: false
fast: false

metaR RE3003M
reversible: true
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/5.3.3.8
fast: false
is described by: ECO:0000000
name: RE3003
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110014#
is: SBO:0000176
product: MODEL1310110014#

metaR EX g1p LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of alpha-D-glucose 1-phosphate(2-)
type: Reaction

metaM 3odcoa m
has only substance units: false
is: HMDB03939
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:28528
name: 3-Oxodecanoyl-CoA

metaR DHFtm
is described by: ECO:0000000
reactant: MODEL1310110014#
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
kinetic law: MODEL1310110014#
type: Reaction
name: dihydrofolate reversible mitochondrial transport

http://identifiers.org/biomodels.db/MODEL1310110014#_5f617244_b4fa_4b25_ae0a_5fec475f4566
is: SBO:0000252
initial amount: NaN
type: Species
name: _AA081045_1_e
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:AA081045
initial concentration: NaN

metaR r0756
fast: false
modifier: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
kinetic law: MODEL1310110014#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.1
notes: GENE_ASSOCIATION: (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:

metaR r0186
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
reactant: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110014#
product: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000000
reversible: false

metaR ACCOAgt
product: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110014#
fast: false
name: acetyl-coa transport
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
kinetic law: MODEL1310110014#
reversible: true
is described by: ECO:0000269

metaR r2380
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110014#
product: MODEL1310110014#

metaR FACOAL180i
type: Reaction
reversible: false
name: C180 fatty acid activation
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110014#
is: SBO:0000176
product: MODEL1310110014#

metaM ksi deg34 l
initial amount: NaN
type: Species
is: CHEBI:16953
is: HMDB00812
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate I, degradation product 34
has only substance units: false
notes: FORMULA: C76H126N5O59S1 CHARGE: -1
constant: false
boundary condition: false

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

metaR PAIL4P HStn
reversible: true
reactant: MODEL1310110014#
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
is: SBO:0000185
kinetic law: MODEL1310110014#

metaR UAGDP
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.7.23
fast: false
name: UDP-N-acetylglucosamine diphosphorylase
type: Reaction
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reversible: false
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
is: SBO:0000176
modifier: MODEL1310110014#

metaR r0731
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
reversible: false
reactant: MODEL1310110014#
is: SBO:0000176
kinetic law: MODEL1310110014#
fast: false
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_e
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0
is: SBO:0000247
boundary condition: false
is: HMDB01659
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:15347
name: Type IIIAb
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_cf4dd2ec_3724_4a16_893a_a2607ea7635a
boundary condition: true
type: Species
initial concentration: NaN
is: B7Z4Y6
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:249
constant: false
name: ALPL
has only substance units: false

metaM ppi c
notes: FORMULA: HO7P2 CHARGE: -3
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00250
boundary condition: false
name: Diphosphate
is: CHEBI:0
type: Species
is: C00013
has only substance units: false
constant: false

metaR MDHm
is version of: http://identifiers.org/ec-code/1.1.1.37
kinetic law: MODEL1310110014#
product: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
is described by: ECO:0000134
name: malate dehydrogenase, mitochondrial
reactant: MODEL1310110014#
is: SBO:0000176
type: Reaction
reversible: true
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_7ad91c7c_743a_4245_8abc_4f0d361e1e76
name: ITPKA
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3706
type: Species
is: P23677
has only substance units: false
initial amount: NaN

metaR r0757
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
type: Reaction
is described by: ECO:0000000
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
fast: false
reversible: true
product: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000176
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.5.4.16
modifier: MODEL1310110014#

metaR TOLBUTAMIDEte
reversible: true
product: MODEL1310110014#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
is described by: ECO:0000000
name: xenobiotic transport

metaM gbside hs c
has only substance units: false
name: globoside
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
is: CHEBI:18259
initial amount: NaN
constant: false
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_2f37da5c_c8b2_4ee8_9985_09ee621eeba9
initial concentration: NaN
name: SLC28A3
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is: Q9HAS3
is encoded by: hsa:64078
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_653bf24b_a511_4e66_9644_c07bf1b74227
name: PIGP
has only substance units: false
is encoded by: hsa:51227
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_ccaafa5e_cd9f_4d38_9742_ea8a22a4e211
constant: false
is: Q0VAA5
is encoded by: hsa:257068
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
name: PLCXD2
initial amount: NaN
initial concentration: NaN

metaR O16G1e
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.10
product: MODEL1310110014#
is: SBO:0000176
fast: false
name: oligo-1,6-glucosidase (glygn4 -> glygn5), extracellular
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110014#
is described by: ECO:0000000
type: Reaction

metaM ncam c
initial amount: NaN
constant: false
is: HMDB01406
name: Nicotinamide
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: C00153
type: Species
is: CHEBI:0
notes: FORMULA: C6H6N2O CHARGE: 0

metaR ASPNATm
is described by: ECO:0000000
product: MODEL1310110014#
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110014#
reversible: false
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.3.1.17 Confidence Level: 4 AUTHORS: PMID:11279290 NOTES:MM
name: aspartate N-acetyltransferase, mitochondrial

metaR GALASE16ly
type: Reaction
reactant: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110014#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110014#

metaR NACHEX8ly
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110014#
product: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction

metaR NMNATr
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.1
is described by: ECO:0000269
modifier: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: nicotinamide-nucleotide adenylyltransferase
is: SBO:0000176
reversible: true

metaM arachdcrn c
constant: false
is: HMDB01322
initial amount: NaN
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
initial concentration: 1.0
has only substance units: false
is: CHEBI:57387
boundary condition: false
name: C20:4 carnitine
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_b1dfe304_5522_4718_b273_79e4e80272cc
name: ST3GAL5
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q9UNP4
is encoded by: hsa:8869
type: Species
initial amount: NaN
is: SBO:0000252
constant: false

metaR r0732
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000176
reversible: false
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110014#_833ab3ac_6e5b_4fb8_af06_4a6b4167cd74
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
name: _R14373_1_x
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:R14373

metaR r0758
reactant: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:8155713,PMID:8605195 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.5.4.16
name: 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase Tryptophan metabolism EC:1.2.1.3
product: MODEL1310110014#
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_eee6b987_f0b2_4d25_a4c9_0375f760d3c8
name: _U37519_1_e
is encoded by: hsa:U37519
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR r2382
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
reversible: false
is: SBO:0000185
modifier: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
fast: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_959add28_1666_4f5d_9755_2d1e003152cc
initial amount: NaN
is: O00219
constant: false
type: Species
is encoded by: hsa:3038
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: HAS3

http://identifiers.org/biomodels.db/MODEL1310110014#_ebb4dce1_6b9b_4cd1_9374_e5eb8c2fa9bd
is encoded by: hsa:30
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: Q96CA6
constant: false
name: ACAA1
initial amount: NaN

metaR PROSTGE1t
name: prostaglandin transport via bicarbonate countertransport
is: SBO:0000185
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
modifier: MODEL1310110014#
product: MODEL1310110014#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ

metaR Coqe
kinetic law: MODEL1310110014#
is: SBO:0000185
product: MODEL1310110014#
reversible: true
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
type: Reaction
fast: false
name: Transport of q10

metaR GMPR
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
type: Reaction
is: SBO:0000176
modifier: MODEL1310110014#
name: GMP reductase
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.7.1.7
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_fa97a8c6_18e9_4ddc_8f19_4549f2145323
is encoded by: hsa:1375
name: CPT1B
constant: false
is: Q53FV7
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR SUBERCROT
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberyl carnitine
type: Reaction

metaR LNLNCGCPT1
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110014#
fast: false
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

metaR S6T6g
fast: false
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
modifier: MODEL1310110014#
reversible: false
type: Reaction
product: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaR MI134P4P
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
product: MODEL1310110014#
type: Reaction
reversible: false
is: SBO:0000176
name: inositol-1,3,4-trisphosphate 4-phosphatase
fast: false
is described by: ECO:0000000
reactant: MODEL1310110014#

metaM h2o n
initial concentration: 1.0
is: HMDB02111
name: water
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:15377

metaM nadph c
name: Nicotinamide adenine dinucleotide phosphate - reduced
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
type: Species
initial concentration: 1.0
has only substance units: false
is: C00005
constant: false
is: CHEBI:57783
is: HMDB00221

metaM ksi deg1 l
constant: false
is: SBO:0000247
name: keratan sulfate I, degradation product 1
boundary condition: false
type: Species
is: CHEBI:18287
has only substance units: false
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
initial concentration: 1.0
is: HMDB00174
initial amount: NaN

metaR SGPL12r
fast: false
kinetic law: MODEL1310110014#
name: Sphingosine-1-phosphate lyase
product: MODEL1310110014#
reversible: false
is: SBO:0000176
is described by: ECO:0000304
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
is version of: http://identifiers.org/ec-code/4.1.2.27
reactant: MODEL1310110014#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_246428bf_d821_49b2_97a9_f15af79ebca9
is: P28330
boundary condition: true
constant: false
name: ACADL
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:33
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_ab1204ca_3f3e_43e8_a62b_93e8902c0774
has only substance units: false
constant: false
is encoded by: hsa:4715
initial concentration: NaN
is: Q9Y6M9
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
name: NDUFB9

metaM g1m8mpdol L r
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species
is: SBO:0000247
is: C05870
initial concentration: 1.0
notes: FORMULA: C1840H3028N20O670P20 CHARGE: -20
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_f18d8930_9fee_404e_8817_e64255d1847a
type: Species
has only substance units: false
initial amount: NaN
name: _AL525798_1_c
boundary condition: true
is encoded by: hsa:AL525798
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_078e37f5_efde_4e78_871f_17e75d0c647b
is: SBO:0000252
boundary condition: true
type: Species
is: P05062
constant: false
is encoded by: hsa:229
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: ALDOB

metaR r0295
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
modifier: MODEL1310110014#
type: Reaction
reversible: false
reactant: MODEL1310110014#
is: SBO:0000176
kinetic law: MODEL1310110014#
product: MODEL1310110014#
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_9b69941a_6694_4c61_8c6c_f1355feab78e
has only substance units: false
is: Q59FD4
name: HK1
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:3098

http://identifiers.org/biomodels.db/MODEL1310110014#_8509c13e_9016_43eb_b278_ea72bdad7f84
is: Q92535
is encoded by: hsa:5279
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
name: PIGC

metaR MCITS
reversible: false
product: MODEL1310110014#
reactant: MODEL1310110014#
name: 2-methylcitrate synthase
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 2.3.3.5 Confidence Level: 2 AUTHORS: PMID:426765,PMID:4507604 NOTES:NCD new EC is 2.3.3.5 - NCD
is: SBO:0000176

metaR G14T5g
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is described by: ECO:0000000
kinetic law: MODEL1310110014#
product: MODEL1310110014#
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR RE2660C
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110014#
is described by: ECO:0000000
kinetic law: MODEL1310110014#
product: MODEL1310110014#
name: RE2660
type: Reaction

metaM leuktrA4 c
has only substance units: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
type: Species
name: leukotriene A4(1-)
initial amount: NaN
is: HMDB01337
initial concentration: 1.0
is: CHEBI:57463
boundary condition: false
is: SBO:0000247
constant: false

metaR 5OXPROt
product: MODEL1310110014#
reversible: true
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: Transport of 5-oxoprolinate
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134

metaR DCK2n
product: MODEL1310110014#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110014#
name: Deoxycytidine kinase, nuclear (UTP)
is version of: http://identifiers.org/ec-code/2.7.1.74
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
type: Reaction

metaR FALDtm
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
reversible: true
reactant: MODEL1310110014#
name: formaldehyde transport via diffusion (mitochondrial)
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110014#
product: MODEL1310110014#

metaM dmnoncrn x
initial amount: NaN
boundary condition: false
name: 4,8-dimethylnonanoyl carnitine
notes: FORMULA: C18H37NO4 CHARGE: 0
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB06202
has only substance units: false

metaR HS4ly
fast: false
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
product: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
name: heparan-N-sulfatase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.10.1.1
is: SBO:0000176
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: false

metaM dudp c
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: C01346
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
type: Species
is: HMDB01000
boundary condition: false
name: dUDP
is: CHEBI:60471
is: SBO:0000247

metaM mmcoa R m
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57326
boundary condition: false
name: (R)-methylmalonyl-CoA(5-)
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
type: Species
has only substance units: false
is: HMDB01269
initial amount: NaN

metaR GLCt1r
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
reversible: true
product: MODEL1310110014#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110014#
is: SBO:0000185
name: glucose transport (uniport)
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110014#_d8bf8685_c563_4951_8d1c_7802eb4d1251
initial concentration: NaN
type: Species
is: SBO:0000252
name: AMY1C
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: P04745
is encoded by: hsa:278

http://identifiers.org/biomodels.db/MODEL1310110014#_348e3866_6f07_4726_bcc0_f031e60c3d9e
type: Species
name: ASNS
is encoded by: hsa:440
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: B4DXZ1
has only substance units: false

metaR C80CPT1
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of octanoylcarnitine
type: Reaction

metaM dectricoa m
name: 2,4,7-decatrienoylcoa
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
type: Species
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
initial concentration: 1.0

metaR ASCBt4
fast: false
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110014#
is described by: ECO:0000269
modifier: MODEL1310110014#
reactant: MODEL1310110014#
name: L-ascorbate transport via proton symport
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_acfaf4d1_f499_40c2_ba19_4ea78361811b
type: Species
is encoded by: hsa:130
is: P28332
initial amount: NaN
has only substance units: false
name: ADH6
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true

metaR r0450
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reversible: true
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.3
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_14ee705e_5098_4d99_a466_10de5fb46f12
type: Species
is encoded by: hsa:2678
is: SBO:0000252
is: P19440
has only substance units: false
name: GGT1
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false

metaM h2o l
name: water
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
type: Species
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:15377
initial concentration: 1.0

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaM ttetddcoa m
has only substance units: false
constant: false
is: HMDB02288
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
initial amount: NaN
name: trans5,8tetradecadienoylcoa
is: SBO:0000247

metaR FAOXC225C226x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_e6427dde_4a24_4cd4_8c3c_4a5a10e31eb2
has only substance units: false
is encoded by: hsa:28232
constant: false
type: Species
is: Q9UIG8
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: SLCO3A1
is: SBO:0000252

metaR FAOXC143C123x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_49c66293_840c_457e_9781_85d3054761d1
is: SBO:0000252
is encoded by: hsa:5209
constant: false
is: Q16875
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
name: PFKFB3

http://identifiers.org/biomodels.db/MODEL1310110014#_704075d4_3cd0_4bd2_addf_3f1c5e9d523d
has only substance units: false
boundary condition: true
initial amount: NaN
name: FTMT
initial concentration: NaN
is encoded by: hsa:94033
is: SBO:0000252
is: Q8N4E7
type: Species
constant: false

metaM h2o m
boundary condition: false
type: Species
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
constant: false
initial amount: NaN
is: C00001
has only substance units: false
initial concentration: 1.0
is: HMDB02111
name: H2O
is: SBO:0000247

metaR HIBDm
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
fast: false
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.1.1.31
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_79aa76bf_99ba_43ff_ae18_045f55eb5356
constant: false
type: Species
is encoded by: hsa:226
is: P04075
is: SBO:0000252
name: ALDOA
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR BILIRUBt2
product: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
is: SBO:0000185
reversible: true
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110014#
name: bilirubin transport via bicarbonate countertransport
modifier: MODEL1310110014#

metaR MAN6PI
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000304
product: MODEL1310110014#
modifier: MODEL1310110014#
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
name: mannose-6-phosphate isomerase
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.8

metaR r1578
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110014#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
reversible: true

metaR CERT1rt
kinetic law: MODEL1310110014#
type: Reaction
name: ceramide transport protein
fast: false
reversible: true
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
is: SBO:0000185
product: MODEL1310110014#
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.11.1

http://identifiers.org/biomodels.db/MODEL1310110014#_d585bc45_ed5f_4eec_8079_3903f40559fa
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
name: SLC2A5
is encoded by: hsa:6518
is: P22732
is: SBO:0000252

metaM h2o r
is: CHEBI:15377
boundary condition: false
name: H2O
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
constant: false
is: C00001
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_a2226ca7_497a_4e9e_8031_e7f6ffe73ba0
has only substance units: false
is encoded by: hsa:8525
initial amount: NaN
constant: false
is: G3V0F6
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: DGKZ
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_b63bbe2a_2dac_4b10_b6e3_f5f40a58e863
initial amount: NaN
has only substance units: false
type: Species
name: DUOX1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:53905
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_4ba65f90_4d56_4941_a66c_dbdebd0231ef
constant: false
has only substance units: false
is encoded by: hsa:8802
name: SUCLG1
initial concentration: NaN
boundary condition: true
is: P53597
is: SBO:0000252
type: Species
initial amount: NaN

metaR ACNACNGALGBSIDEte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
product: MODEL1310110014#
reversible: true
kinetic law: MODEL1310110014#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: acnacngalgbside hs transport
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_7c664ef4_0890_4733_8aae_37346fc8ff9e
is: P08397
boundary condition: true
name: HMBS
has only substance units: false
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:3145
is: SBO:0000252
initial concentration: NaN

metaR PGMT
is: SBO:0000176
is described by: ECO:0000134
name: phosphoglucomutase
is version of: http://identifiers.org/ec-code/5.4.2.2
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#
fast: false
reversible: true
modifier: MODEL1310110014#
type: Reaction

metaM ksii core2 pre8 g
notes: FORMULA: C75H121N6O56SX CHARGE: -2
initial amount: NaN
is: HMDB00175
has only substance units: false
is: C00130
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:58053
type: Species
constant: false
name: keratan sulfate II biosynthesis, precursor 8

metaM cs b deg2 l
initial concentration: 1.0
boundary condition: false
is: HMDB00812
initial amount: NaN
constant: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:16953
notes: FORMULA: C37H54NO41S3 CHARGE: -5

http://identifiers.org/biomodels.db/MODEL1310110014#_f890ae38_af83_4e91_baf9_769f0ee3f7bd
initial concentration: NaN
name: ADO
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:84890
is: B3KXN9
has only substance units: false
boundary condition: true
type: Species

metaR ACACT4p
is: SBO:0000176
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
fast: false
modifier: MODEL1310110014#
reversible: false
name: acetyl-CoA C-acetyltransferase (octanoyl-CoA), peroxisomal
is described by: ECO:0000269
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110014#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_180c0058_940c_40fc_ad93_2ba6fc836af6
is: O75610
type: Species
initial concentration: NaN
constant: false
name: LEFTY1
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10637
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_bd02c5fb_8e43_42c2_8b29_1495b20297e2
boundary condition: true
initial amount: NaN
is: B7Z3I7
initial concentration: NaN
is: SBO:0000252
name: MDH1
is encoded by: hsa:4190
has only substance units: false
type: Species
constant: false

metaM CE4872 c
is: HMDB00127
boundary condition: false
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
constant: false
is: CHEBI:15748
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_e0fe4622_7d72_40f3_a1a4_f23803045a5a
is: SBO:0000252
is encoded by: hsa:5631
initial concentration: NaN
has only substance units: false
is: P60891
boundary condition: true
constant: false
initial amount: NaN
name: PRPS1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_bc1d1a61_6a2c_4279_bd49_1872d66f15c3
is: Q674R7
is encoded by: hsa:285973
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
name: ATG9B
boundary condition: true
type: Species
is: SBO:0000252

metaM rib D c
is: SBO:0000247
is: HMDB00283
name: D-ribose
is: CHEBI:16988
type: Species
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
boundary condition: false
initial concentration: 1.0

metaM CE4793 x
type: Species
notes: FORMULA: C41H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29(49)24-32(51)70-23-22-43-31(50)20-21-44-39(54)36(53)41(2,3)26-63-69(60,61)66-68(58,59)62-25-30-35(65-67(55,56)57)34(52)40(64-30)48-28-47-33-37(42)45-27-46-38(33)48/h8-9,11-12,14-15,27-28,30,34-36,40,52-53H,4-7,10,13,16-26H2,1-3H3,(H,43,50)(H,44,54)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/b9-8-,12-11-,15-14-/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4793
is: CHEBI:57923
is: SBO:0000247
initial amount: NaN
name: 3-oxo-dihomo-gama-linolenoyl-CoA
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false

metaM 2decdicoa m
type: Species
initial concentration: 1.0
name: 2,7-decadienoylcoa
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H46N7O17P3S CHARGE: -4

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaR ACNACNGALGBSIDEtg
product: MODEL1310110014#
reversible: true
type: Reaction
kinetic law: MODEL1310110014#
is: SBO:0000185
name: acnacngalgbside hs intracellular transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
fast: false
reactant: MODEL1310110014#

metaR FE3MTP1
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
is described by: ECO:0000134
product: MODEL1310110014#
fast: false
is: SBO:0000185
modifier: MODEL1310110014#
type: Reaction
name: transport of ferrous iron into blood
reversible: false
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_3bbf8e4c_e4c4_459d_b73d_3210eb395caf
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: SCD
boundary condition: true
constant: false
is encoded by: hsa:6319
is: O00767
initial amount: NaN
type: Species

metaR NACHEX20ly
is described by: ECO:0000000
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110014#
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaR r0750
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110014#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110014#

metaM 5aop c
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: 5-Amino-4-oxopentanoate
is: C00430
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:17549
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: HMDB01149
constant: false

metaR CHOLESTle
is version of: http://identifiers.org/ec-code/3.1.1.13
kinetic law: MODEL1310110014#
product: MODEL1310110014#
name: hydrolysis of cholesterol ester by cholesterol esterase
is: SBO:0000176
reactant: MODEL1310110014#
modifier: MODEL1310110014#
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134

metaR r1579
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true
product: MODEL1310110014#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

metaM malthx e
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247
type: Species
initial concentration: 1.0
name: Maltohexaose
constant: false
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
is: C01936
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_bea2fa34_d705_48d2_92c8_79ab3b5d59b4
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8622
boundary condition: true
initial amount: NaN
type: Species
name: PDE8B
is: O95263
constant: false
initial concentration: NaN

metaM leuktrA4 e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
initial amount: NaN
is: SBO:0000247
is: HMDB01337
type: Species
name: leukotriene A4(1-)
has only substance units: false
is: CHEBI:57463
constant: false

metaR LNLNCGCPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
product: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_8481d722_e5f4_4d60_9bdd_9f67f88becdb
name: _AI694761_1_c
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI694761

metaM fadh2 c
initial concentration: 1.0
name: FADH2(2-)
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
initial amount: NaN
boundary condition: false
type: Species
is: HMDB01197
is: CHEBI:58307
is: SBO:0000247
has only substance units: false
constant: false

metaR SUCOASm
fast: false
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
is version of: http://identifiers.org/ec-code/6.2.1.5
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000
name: Succinate--CoA ligase (ADP-forming)
reactant: MODEL1310110014#
type: Reaction
modifier: MODEL1310110014#
product: MODEL1310110014#
reversible: true

metaR r0443
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
reactant: MODEL1310110014#
is: SBO:0000176
product: MODEL1310110014#

metaR FADH2tru
name: FADH2 transporter, endoplasmic reticulum
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
type: Reaction
kinetic law: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110014#
reversible: false

metaM pglyc hs e
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:60523
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
name: phosphatidylglycerol(1-)

metaR ACACT7p
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
modifier: MODEL1310110014#
type: Reaction
reversible: false

metaR FAOXC165C164x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:5-->C16:4)x
type: Reaction

metaM urate c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:17775
is: C00366
is: SBO:0000247
type: Species
is: HMDB00289
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
name: Urate
has only substance units: false
constant: false

metaM melatn c
has only substance units: false
initial amount: NaN
notes: FORMULA: C13H16N2O2 CHARGE: 0 INCHI: InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C01598
constant: false
type: Species
boundary condition: false
is: HMDB01389
name: melatonin
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16796

metaM ksii core2 l
initial amount: NaN
type: Species
is: HMDB03418
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:16443
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
initial concentration: 1.0
constant: false
name: keratan sulfate II (core 2-linked)

metaR NACASPAH
name: N-Acetyl-L-aspartate amidohydrolase
is described by: ECO:0000269
product: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.15
reversible: false
modifier: MODEL1310110014#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (443.1) or (91703.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.15 Confidence Level: 4 AUTHORS: PMID:8252036 NOTES:SAB

metaR r1708
fast: false
modifier: MODEL1310110014#
is: SBO:0000185
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110014#

metaM chsterol m
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00067
initial amount: NaN
constant: false
type: Species
name: cholesterol
is: CHEBI:16113
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_00c1b81e_77f2_46da_b92f_7b8b99f0f760
is encoded by: hsa:2639
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
name: GCDH
is: Q92947

metaM 5mta e
is: CHEBI:17509
type: Species
initial concentration: 1.0
notes: FORMULA: C11H15N5O3S CHARGE: 0
is: C00170
is: SBO:0000247
constant: false
is: HMDB01173
boundary condition: false
name: 5-Methylthioadenosine
initial amount: NaN
has only substance units: false

metaM 4aphdob c
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
constant: false
is: CHEBI:58147
type: Species
boundary condition: false
initial concentration: 1.0
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
has only substance units: false
is: SBO:0000247
is: HMDB00978
initial amount: NaN

metaM atp r
has only substance units: false
is: SBO:0000247
constant: false
type: Species
boundary condition: false
is: HMDB00538
is: C00002
name: ATP(4-)
initial amount: NaN
is: CHEBI:57299
initial concentration: 1.0

metaR DCYTDn
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000176
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.5.4.5
fast: false
reversible: false
name: deoxycytidine deaminase, nuclear
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
type: Reaction
is described by: ECO:0000254

metaM acgal c
initial amount: NaN
is: CHEBI:28037
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
constant: false
boundary condition: false
is: HMDB00212
has only substance units: false
name: N-acetyl-D-galactosamine
initial concentration: 1.0
is: SBO:0000247

metaR SCP21x
modifier: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.176
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000269
name: Sterol carrier protein 2
product: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ

metaR ACNAMlt
reactant: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
kinetic law: MODEL1310110014#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110014#
reversible: true
name: N-acetylneuraminate transport into lysososme
fast: false
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_16f05ca0_a592_4d30_af09_775955771016
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
name: SOD1
is: SBO:0000252
is: P00441
is encoded by: hsa:6647

http://identifiers.org/biomodels.db/MODEL1310110014#_ee3ec5ab_7279_4456_946e_1cc4bc9a5775
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
name: ACAD9
is encoded by: hsa:28976
boundary condition: true
initial concentration: NaN
is: Q9H845
has only substance units: false

metaR PYRt2m
fast: false
is described by: ECO:0000000
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
reversible: true
modifier: MODEL1310110014#
name: pyruvate mitochondrial transport via proton symport
is: SBO:0000185
type: Reaction
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#

metaR ECOAH9m
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_0cfa11ab_9123_4285_9a33_2c01a535a555
name: SLC2A6
is: Q9UGQ3
is encoded by: hsa:11182
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false

metaR RE3326M
modifier: MODEL1310110014#
is: SBO:0000176
name: RE3326
reversible: true
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
is version of: http://identifiers.org/ec-code/1.2.4.4
fast: false
type: Reaction
product: MODEL1310110014#
is described by: ECO:0000000
kinetic law: MODEL1310110014#

metaR HOCTDECCRNe
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyoctadecanoyl carnitine into extra cellular space
type: Reaction

metaM pglyc hs c
is: HMDB02704
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: CHARGE: 0
boundary condition: false
is: CHEBI:21338
name: pglyc_hs[c]

metaR PHEMEt
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
reversible: false
product: MODEL1310110014#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: heme transport

metaM urate e
initial concentration: 1.0
is: C00366
is: CHEBI:17775
boundary condition: false
is: SBO:0000247
is: HMDB00289
type: Species
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
name: Urate
constant: false
initial amount: NaN
has only substance units: false

metaM ak2lgchol hs e
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
is: C04317
is: http://identifiers.org/pubchem.compound/6975
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_fb88b17c_0d04_4116_b168_e57f9397b3c0
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
name: _NM_013421_1_m
is encoded by: hsa:NM 013421
constant: false
boundary condition: true
is: SBO:0000252

metaM CE2839 e
is: C01936
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
initial amount: NaN
has only substance units: false
type: Species
name: maltodecaose
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false

metaM ksii core4 pre2 g
name: keratan sulfate II boisynthesis, precursor 2
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C47H76N4O33X CHARGE: -1
type: Species
boundary condition: false
is: C00130
is: SBO:0000247
initial amount: NaN
is: CHEBI:58053
is: HMDB00175

metaR r2347
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110014#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true

metaR FAOXC8C6m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_b6ba8f5e_9148_4ddf_b5c0_0b8903fcd50a
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P37268
type: Species
name: FDFT1
is: SBO:0000252
is encoded by: hsa:2222

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaM 3hddcoa m
constant: false
is: HMDB11123
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
is: C05279
has only substance units: false
boundary condition: false
type: Species
name: (S)-3-Hydroxydodecanoyl-CoA
initial amount: NaN

metaR FBP
product: MODEL1310110014#
fast: false
type: Reaction
is described by: ECO:0000000
name: fructose-bisphosphatase
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (2203.1) or (8789.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.11 Confidence Level: 0 AUTHORS: PMID:9678974 NOTES:SMP
is: SBO:0000176
reversible: false
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.3.11
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_cba23951_e8ca_4ad5_a7ed_4100e39f8323
initial amount: NaN
is encoded by: hsa:5167
type: Species
is: P22413
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
name: ENPP1
is: SBO:0000252

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaR FAOXC184C164m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)m
type: Reaction

metaR ACOAD9m
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
kinetic law: MODEL1310110014#
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial
reactant: MODEL1310110014#
is: SBO:0000176
reversible: false

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_8f17c81c_ba2c_48bd_b7cd_9fe2501d1888
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3948
initial concentration: NaN
type: Species
has only substance units: false
name: LDHC
boundary condition: true
constant: false

metaR r2346
is described by: ECO:0000000
reactant: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110014#

metaR THMP
is described by: ECO:0000000
name: thiamin phosphatase
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD
reversible: false
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#

metaM chsterol r
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: HMDB00067
has only substance units: false
initial amount: NaN
is: CHEBI:16113
initial concentration: 1.0
name: cholesterol
is: SBO:0000247
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_993116a9_2f05_49a1_b566_d18868ac44f6
is: SBO:0000252
is: E5KNH5
is encoded by: hsa:4723
constant: false
type: Species
name: NDUFV1
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_10e07043_dfdd_42f3_8489_67d7b3bdaf51
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5331
name: PLCB3
initial concentration: NaN
is: G5E960
type: Species
boundary condition: true

metaM adrn e
name: adrenic acid
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:53487
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
is: HMDB02226
has only substance units: false

metaM 4nph e
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
type: Species
name: 4-nitrophenolate
is: HMDB01232
has only substance units: false
initial concentration: 1.0
is: CHEBI:57917

metaM pyam5p c
is: CHEBI:58451
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: C00647
name: Pyridoxamine 5'-phosphate
is: HMDB01555
initial amount: NaN
notes: FORMULA: C8H12N2O5P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00475 EHMN_ABBREVIATION: C00647
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_7e1d3ac3_f7b6_416b_844f_0d8248b2fa5c
name: SUCLG2:SUCLG1
is: SBO:0000297
is encoded by: hsa:8801
constant: false
has part: P53597
has only substance units: false
initial concentration: NaN
has part: Q96I99
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:8802

http://identifiers.org/biomodels.db/MODEL1310110014#_9029f3c4_2a8c_4ab9_98b1_916ba62db9b0
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8372
constant: false
is: SBO:0000252
type: Species
name: HYAL3
boundary condition: true
is: O43820
has only substance units: false

metaM estradiol e
is: HMDB00151
has only substance units: false
initial concentration: 1.0
name: estradiol
type: Species
initial amount: NaN
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:16469

http://identifiers.org/biomodels.db/MODEL1310110014#_metaM_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_c
initial amount: NaN
has only substance units: false
is: CHEBI:12936
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00143
notes: FORMULA: C96H165N4O60FULLRCO CHARGE: 0
type: Species
initial concentration: 1.0
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1

metaM HC00319 m
constant: false
initial amount: NaN
is: CHEBI:30794
has only substance units: false
name: Malonate
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
type: Species
boundary condition: false

metaM dec24dicoa m
name: 2,4-decadienoylcoa
initial concentration: 1.0
boundary condition: false
is: HMDB01168
constant: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR LACLt
reversible: false
fast: false
reactant: MODEL1310110014#
name: Lactate transport
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMCID: PMC1820816. NOTES:for regeneration of nad in peroxisomes, for providing nad to the beta oxidation

http://identifiers.org/biomodels.db/MODEL1310110014#_72dc62c7_b353_4c0c_81fe_3592461c4c02
name: BHMT2
is: Q9H2M3
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:23743
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaR NADtru
reversible: false
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110014#
name: NAD transporter, endoplasmic reticulum
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ

http://identifiers.org/biomodels.db/MODEL1310110014#_2d0bcc59_1074_4c92_80bf_8f5403d211e5
is encoded by: hsa:AA532636
name: _AA532636_1_m
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false

metaR r1540
is described by: ECO:0000000
reactant: MODEL1310110014#
reversible: false
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
product: MODEL1310110014#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
modifier: MODEL1310110014#
fast: false

metaR APOC LYS BTNP
product: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
name: proteolysis of apoC-Lys-btn
is: SBO:0000176
reactant: MODEL1310110014#
type: Reaction
reversible: false
kinetic law: MODEL1310110014#

metaR CHAT
name: Choline O-acetyltransferase
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.6
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ

metaM strdnccoa c
initial amount: NaN
has only substance units: false
is: C16163
boundary condition: false
initial concentration: 1.0
is: HMDB06519
is: http://identifiers.org/pubchem.compound/47205473
type: Species
name: stearidonyl coenzyme A
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_319bc774_140e_4189_8882_afe9a1fc6082
boundary condition: true
is encoded by: hsa:2762
is: O60547
initial amount: NaN
has only substance units: false
type: Species
name: GMDS
initial concentration: NaN
is: SBO:0000252
constant: false

metaM ksi pre24 g
boundary condition: false
is: SBO:0000247
constant: false
type: Species
has only substance units: false
is: HMDB00175
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
initial amount: NaN
is: C00130
name: keratan sulfate I biosynthesis, precursor 24
is: CHEBI:58053
initial concentration: 1.0

metaR FAOXC164C163x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)x
type: Reaction

metaM tdchola x
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
boundary condition: false
initial concentration: 1.0
constant: false
name: taurochenodeoxycholate
has only substance units: false
is: CHEBI:9407
is: HMDB00951
type: Species

metaR B3GALT5g
reversible: false
type: Reaction
reactant: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110014#
is described by: ECO:0000269
name: Beta-1,3-galactosyltransferase 5
product: MODEL1310110014#

metaR r2344
name: Organic anion transporter 5 Utilized transport
fast: false
is described by: ECO:0000000
reactant: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110014#
is: SBO:0000185
reversible: true

metaR FUMTSULtm
modifier: MODEL1310110014#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Fumarate:thiosulfate antiport, mitochondrial
fast: false
reactant: MODEL1310110014#
reversible: true
type: Reaction

metaR ILEPHELAT2tc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Isoleucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR MDHx
fast: false
reversible: true
reactant: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
name: malate dehydrogenase, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: Confidence Level: 2 AUTHORS: PMID: 17173541 NOTES:added during gap filling. Assumption that such a reaction can exist. Mamalian peroxisome do not contain malate dehydrogenase.
kinetic law: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176

metaR r1705
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: false
is described by: ECO:0000000
product: MODEL1310110014#
type: Reaction
name: Y+LAT2 Utilized transport
is: SBO:0000185
reactant: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM 4nph c
is: CHEBI:57917
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: 4-nitrophenolate
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: HMDB01232

metaR BDMT L
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (liver)
fast: false
modifier: MODEL1310110014#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.142
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000176
product: MODEL1310110014#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_ca52d2e9_7758_41f7_8eed_57f992858702
is: SBO:0000252
is: Q15181
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: PPA1
is encoded by: hsa:5464

metaR FAOXC204184m
reversible: false
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
name: Beta oxidation fatty acid
modifier: MODEL1310110014#
fast: false
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 rounds of beta ox c20:4 -> c18:4 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110014#_1bfd48d3_368c_4c1d_a2fa_71d4e83a575b
initial amount: NaN
name: CHAT
initial concentration: NaN
has only substance units: false
type: Species
is: Q6LEN5
boundary condition: true
is encoded by: hsa:1103
constant: false
is: SBO:0000252

metaM adrn c
boundary condition: false
is: HMDB02226
has only substance units: false
constant: false
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
initial concentration: 1.0
is: CHEBI:53487
initial amount: NaN
name: adrenic acid
type: Species
is: SBO:0000247

metaM camp c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00058
is: CHEBI:58165
name: 3',5'-cyclic AMP(1-)
type: Species
initial amount: NaN
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
constant: false

metaR GALASE7ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.6.4
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110014#

metaR r2343
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
kinetic law: MODEL1310110014#
is described by: ECO:0000000
product: MODEL1310110014#
is: SBO:0000185
type: Reaction
name: Organic anion transporter 5 Utilized transport
fast: false

metaM pyr c
is: CHEBI:15361
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00243
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1
initial amount: NaN
name: pyruvate
is: http://identifiers.org/pubchem.compound/3324
is: C00022
boundary condition: false

metaR r0339
type: Reaction
is: SBO:0000176
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.22
reactant: MODEL1310110014#
reversible: false
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.2.2
modifier: MODEL1310110014#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65

metaM 5mta c
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
is: CHEBI:17509
boundary condition: false
is: SBO:0000247
is: C00170
type: Species
name: 5-Methylthioadenosine
constant: false
is: HMDB01173
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR GGH 5DHFe
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
name: Gamma-glutamyl hydrolase (5DHF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
is described by: ECO:0000000
type: Reaction
product: MODEL1310110014#
is: SBO:0000176
reversible: false
fast: false

metaM CE4872 m
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:15748
type: Species
boundary condition: false
constant: false
has only substance units: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
is: HMDB00127

metaM atp x
initial amount: NaN
is: C00002
initial concentration: 1.0
is: CHEBI:57299
name: ATP(4-)
has only substance units: false
type: Species
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00538

http://identifiers.org/biomodels.db/MODEL1310110014#_ac653c42_cbc2_4ea0_a0d9_4f1b2a4787b8
type: Species
has only substance units: false
name: AK2
is encoded by: hsa:204
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR OCD11CRNCPT2
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_b53a707c_0200_401e_b1dd_c84c63afa8d4
name: ALDH1A3
constant: false
is encoded by: hsa:220
is: P47895
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaM rib D e
boundary condition: false
is: CHEBI:16988
constant: false
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00283
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
name: D-ribose
initial amount: NaN

metaR GULNter
fast: false
reactant: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: L-gulonate endoplasmic reticular export
kinetic law: MODEL1310110014#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110014#_metaM_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_g
type: Species
notes: FORMULA: C96H165N4O60FULLRCO CHARGE: 0
initial amount: NaN
initial concentration: 1.0
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
is: CHEBI:61648
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247

metaM galside hs e
is: SBO:0000247
has only substance units: false
is: CHEBI:12947
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial amount: NaN
name: D-galactosyl-N-acylsphingosine

metaM pail34p hs c
constant: false
initial amount: NaN
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
type: Species
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57658

metaM xoldioloneh c
has only substance units: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
boundary condition: false
initial concentration: 1.0
is: HMDB06887
is: CHEBI:2288
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
type: Species
initial amount: NaN
constant: false
is: SBO:0000247

metaM nrpphrsf c
is: http://identifiers.org/pubchem.compound/123747
is: SBO:0000247
is: HMDB02062
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
name: Sulfate derivative of norepinephrine
type: Species
initial concentration: 1.0

metaM cbasp c
is: C00438
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:32814
has only substance units: false
boundary condition: false
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
initial concentration: 1.0
is: HMDB00828
name: N-Carbamoyl-L-aspartate

metaR FUCtly
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
name: L-fucose efflux from lysosome
type: Reaction

metaM acgal l
is: HMDB00212
is: CHEBI:28037
type: Species
name: N-acetyl-D-galactosamine
initial concentration: 1.0
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_fc34a349_de03_49f8_99e9_ff10cd9a5791
is: P30520
boundary condition: true
is encoded by: hsa:159
constant: false
name: ADSS
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN

metaM Rtotal2coa c
name: R total 2 coenzyme A
type: Species
is: HMDB01564
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57876
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
constant: false
is: SBO:0000247

metaR r2342
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
fast: false
name: Organic anion transporter 5 Utilized transport
type: Reaction
kinetic law: MODEL1310110014#
is: SBO:0000185
product: MODEL1310110014#
reversible: true

metaR RE0383C
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
fast: false
reversible: true
reactant: MODEL1310110014#
is: SBO:0000176
product: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.2
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
is described by: ECO:0000000
name: RE0383

metaM dolp U c
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: CHEBI:57683
is: SBO:0000247
constant: false
name: dolichyl phosphate(2-)
initial amount: NaN

metaM ala B m
is: HMDB00056
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
name: beta-alanine
initial concentration: 1.0
constant: false
is: CHEBI:16958
type: Species
is: SBO:0000247

metaR F1PGT
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
name: fucose-1-phosphate guanylyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.30
type: Reaction
product: MODEL1310110014#
reversible: true
modifier: MODEL1310110014#
is described by: ECO:0000000
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_51116c64_6517_4906_97b5_c70364acd567
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8604
constant: false
type: Species
boundary condition: true
is: O75746
name: SLC25A12
initial amount: NaN

metaR PYRt2r
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
reactant: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
reversible: true
fast: false
is: SBO:0000185
name: pyruvate reversible transport via proton symport
is described by: ECO:0000269
product: MODEL1310110014#

metaM estradiol r
type: Species
boundary condition: false
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
name: estradiol
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16469
is: HMDB00151
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_167d90b1_e080_44ac_9c60_d936a360bc50
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
name: ALPI
initial concentration: NaN
is: P09923
is encoded by: hsa:248

metaM chsterol e
type: Species
is: SBO:0000247
is: CHEBI:16113
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
name: cholesterol
initial concentration: 1.0
is: HMDB00067
constant: false
boundary condition: false
initial amount: NaN

metaR r0022
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110014#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.8.1.7

metaR B3GNT312g
fast: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
reversible: false
kinetic law: MODEL1310110014#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
product: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000254
type: Reaction
is: SBO:0000176
reactant: MODEL1310110014#

metaM gbside hs l
initial amount: NaN
constant: false
name: globoside
is: CHEBI:18259
has only substance units: false
boundary condition: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_b0fee9d1_efb7_4ce2_a4ac_865669fedd3d
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:29920
type: Species
initial amount: NaN
is: Q96C36
name: PYCR2
boundary condition: true
constant: false

metaR r2341
name: Organic anion transporter 5 Utilized transport
reversible: true
kinetic law: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
product: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
fast: false

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaM pyr e
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00243
constant: false
is: CHEBI:15361
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
boundary condition: false
type: Species
name: pyruvate
initial amount: NaN

metaM Ssq23epx r
has only substance units: false
constant: false
is: HMDB01188
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
boundary condition: false
is: CHEBI:15441
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: (S)-2,3-epoxysqualene

metaM galside hs c
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:12947
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
name: D-galactosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686

http://identifiers.org/biomodels.db/MODEL1310110014#_metaM_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_e
is: C00124
notes: FORMULA: C96H165N4O60FULLRCO CHARGE: 0
initial concentration: 1.0
has only substance units: false
is: HMDB00143
initial amount: NaN
constant: false
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
type: Species
is: SBO:0000247
is: CHEBI:0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_60dad489_a9c4_4135_87f3_86d97ef7595d
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
name: _F23536_1_m
boundary condition: true
has only substance units: false
is encoded by: hsa:F23536
initial concentration: NaN

metaR FACOAL1812
product: MODEL1310110014#
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true
is: SBO:0000176
name: fatty-acid--CoA ligase
is described by: ECO:0000000
reactant: MODEL1310110014#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_8572a94b_b2ec_4bd0_b915_86dbdbb9de2b
has only substance units: false
name: PRODH
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
is: O43272
type: Species
initial concentration: NaN
is encoded by: hsa:5625

metaR HTDCACBP
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxytetradecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM 3pg c
is: CHEBI:58272
is: http://identifiers.org/pubchem.compound/3497
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
name: 3-Phospho-D-glycerate
boundary condition: false
is: HMDB00807
is: C00197
constant: false

metaR r0021
product: MODEL1310110014#
modifier: MODEL1310110014#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
fast: false
reactant: MODEL1310110014#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
type: Reaction
kinetic law: MODEL1310110014#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5

http://identifiers.org/biomodels.db/MODEL1310110014#_3dcda5a1_e59c_424d_9558_c223bccd5cad
name: TXNRD3
is encoded by: hsa:114112
is: Q86VQ6
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true

metaR BILDGLCURt
is described by: ECO:0000269
reversible: true
product: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
is: SBO:0000185
type: Reaction
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110014#

metaR UPPDC1
fast: false
kinetic law: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Heme synthesis EC Number: 4.1.1.37 Confidence Level: 4 AUTHORS: PMID:3015909 NOTES:Acts on a number of porphyrinogens, r0606
name: uroporphyrinogen decarboxylase (uroporphyrinogen III)
modifier: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.1.1.37
is: SBO:0000176

metaM HC01603 c
is: SBO:0000247
name: 10-Formyltetrahydrofolate
is: CHEBI:57454
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: C00234
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
type: Species
constant: false
initial amount: NaN

metaR PTE4x
modifier: MODEL1310110014#
fast: false
product: MODEL1310110014#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110014#
reversible: false
name: peroxisomal acyl-CoA thioesterase
is version of: http://identifiers.org/ec-code/3.1.2.2
reactant: MODEL1310110014#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110014#_7a9f1dba_72c6_4bfd_acc3_0982f8d3016c
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:4710
boundary condition: true
initial concentration: NaN
has only substance units: false
name: NDUFB4
is: O95168
type: Species

metaR ACETONEt2
fast: false
is described by: ECO:0000269
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
name: acetone transport via proton symport
is: SBO:0000185
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true
type: Reaction
product: MODEL1310110014#

metaM 42A3HP24DB c
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
has only substance units: false
constant: false
type: Species
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
is: HMDB04083
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: C05645
is: http://identifiers.org/pubchem.compound/7956

http://identifiers.org/biomodels.db/MODEL1310110014#_9181d0a0_52f1_4c75_b64c_62180b02ab94
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:54407
has only substance units: false
constant: false
name: SLC38A2
initial concentration: NaN
is: Q96QD8

metaM pre prot r
notes: FORMULA: XY CHARGE: 0
constant: false
is: CHEBI:16240
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB03125
name: glycophosphatidylinositol (GPI)-anchored protein precursor
has only substance units: false

metaR EX pydxn LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Pyridoxine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_b7285408_e16b_47b1_8901_ae01dd5446d1
initial concentration: NaN
name: PCBD2
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is: Q9H0N5
initial amount: NaN
is encoded by: hsa:84105

metaM atp n
type: Species
is: CHEBI:57299
boundary condition: false
constant: false
initial amount: NaN
name: ATP(3-)
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
is: HMDB00538
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR HEXDIACTD
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

metaM dgpi prot hs r
initial amount: NaN
has only substance units: false
notes: FORMULA: C39H76N4O37P4FULLRCO2FULLR2CO2X CHARGE: 0
constant: false
boundary condition: false
is: CHEBI:16311
is: C00458
initial concentration: 1.0
is: SBO:0000247
name: deacylated-glycophosphatidylinositol (GPI)-anchored protein
is: HMDB00998
type: Species

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaR PHYHx
is version of: http://identifiers.org/ec-code/1.14.11.18
is described by: ECO:0000269
name: Phytanoyl-CoA dioxygenase, peroxisomal
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
reversible: false
product: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: (5264.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.14.11.18 Confidence Level: 4 AUTHORS: PMID:8954107,PMID:9326940 NOTES:NJ
is: SBO:0000176

metaM doco13ecoa c
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/24892791
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: 13-docosenoylcoa
initial amount: NaN
is: SBO:0000247

metaR r0027
modifier: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
kinetic law: MODEL1310110014#
is: SBO:0000176
type: Reaction
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.39
product: MODEL1310110014#
reactant: MODEL1310110014#

metaR HS3ly
fast: false
product: MODEL1310110014#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.10.1.1
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
name: heparan-N-sulfatase, lysosomal
reversible: false
is described by: ECO:0000000

metaM acgal g
initial amount: NaN
has only substance units: false
is: CHEBI:28037
is: SBO:0000247
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
boundary condition: false
is: HMDB00212
initial concentration: 1.0
constant: false
name: N-acetyl-D-galactosamine

metaM prgnlones c
is: HMDB00774
initial concentration: 1.0
is: CHEBI:35420
is: SBO:0000247
name: pregnenolone sulfate
type: Species
notes: FORMULA: C21H31O5S CHARGE: -1 INCHI: InChI=1S/C21H32O5S/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19H,5-12H2,1-3H3,(H,23,24,25)/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: CE4764
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_5f6eddbd_ce29_4353_a822_449f877fb322
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: CHST6
is: SBO:0000252
boundary condition: true
is: Q9GZX3
type: Species
constant: false
is encoded by: hsa:4166

metaR FAOXC122x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)x
type: Reaction

metaR FACOAL1813
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
product: MODEL1310110014#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110014#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110014#
name: fatty-acid--CoA ligase
modifier: MODEL1310110014#

metaM HC02179 c
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:34306
name: 20-hydroxy-arachidonate
has only substance units: false
constant: false
type: Species
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748

metaR r1106
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110014#
name: Postulated transport reaction
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_6434a401_40c5_4def_afb1_212d3c07200f
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:18
name: ABAT
initial amount: NaN
is: P80404
constant: false
has only substance units: false

metaR ABO6g
product: MODEL1310110014#
is: SBO:0000176
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
is described by: ECO:0000269
fast: false
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.37
type: Reaction
reactant: MODEL1310110014#
reversible: false

metaM 3thexddcoacrn c
type: Species
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C23H41NO5 CHARGE: 0
has only substance units: false
boundary condition: false
is: HMDB02014

metaM atp m
is: HMDB00538
is: SBO:0000247
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
name: ATP(4-)
initial amount: NaN
is: CHEBI:57299
is: C00002
boundary condition: false

metaM odecrn m
boundary condition: false
is: HMDB01114
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
initial amount: NaN
is: C00412
constant: false
type: Species
has only substance units: false
name: octadecenoyl carnitine
is: SBO:0000247
is: CHEBI:57394
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_a6a6c7d0_b24a_40d5_83c1_5de7e72b75f1
is encoded by: hsa:AL048840
has only substance units: false
constant: false
boundary condition: true
name: _AL048840_1_c
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_e4d38a61_022d_4909_ad64_42e551de04bf
initial concentration: NaN
is: O95427
constant: false
name: PIGN
has only substance units: false
type: Species
is encoded by: hsa:23556
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_ffb8f485_24a2_4e33_b5a3_b17b7f3cdf74
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3633
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: P32019
type: Species
name: INPP5B

http://identifiers.org/biomodels.db/MODEL1310110014#_9589b86d_cf46_4a88_ad72_1c768b7543cf
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:23428
name: SLC7A8:SLC3A2
boundary condition: true
is: SBO:0000297
has part: Q9UHI5
has only substance units: false
initial concentration: NaN

metaR TCYNTtm
fast: false
name: Thiocyanate transport via diffusion (mitochondrial)
type: Reaction
reversible: false
kinetic law: MODEL1310110014#
is described by: ECO:0000000
product: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM

metaR FAOXC165C164m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_89d98b96_c453_4929_8797_9be12b159a43
initial amount: NaN
name: AK4
constant: false
initial concentration: NaN
is encoded by: hsa:205
is: SBO:0000252
type: Species
is: P27144
has only substance units: false
boundary condition: true

metaR FBA
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
modifier: MODEL1310110014#
is: SBO:0000176
product: MODEL1310110014#
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/4.1.2.13
is described by: ECO:0000134
type: Reaction
reversible: true
name: fructose-bisphosphate aldolase
fast: false
kinetic law: MODEL1310110014#

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

metaM dolmanp U c
boundary condition: false
name: Dolichyl phosphate D-mannose, human uterine homolog
type: Species
is: CHEBI:15809
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
has only substance units: false

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_a93c7da1_f6b4_449c_99fd_5a596a6ef961
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10993
name: SDS
boundary condition: true
initial concentration: NaN
is: P20132

metaM nrpphrsf e
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/123747
constant: false
initial concentration: 1.0
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
has only substance units: false
initial amount: NaN
type: Species
name: Sulfate derivative of norepinephrine
boundary condition: false
is: HMDB02062

http://identifiers.org/biomodels.db/MODEL1310110014#_7136737e_5dcd_43ed_8392_a83f9820d47b
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: NDUFB9
is encoded by: hsa:4715
type: Species
constant: false
is: Q9Y6M9
has only substance units: false
is: SBO:0000252

metaR DOCO13ECOAtxc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 13-docosenoylcoa into peroxisomes
type: Reaction

metaM acmana c
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
is: CHEBI:17122
name: N-acetyl-D-mannosamine
initial amount: NaN
has only substance units: false
is: HMDB01129
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_a835903e_6d18_40a5_8e23_659ca7babd69
type: Species
is: P23743
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1606
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: DGKA

metaM galside hs g
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:12947
name: D-galactosyl-N-acylsphingosine
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686

http://identifiers.org/biomodels.db/MODEL1310110014#_aec05ea7_528b_4c88_b2c3_ab7160aec221
has only substance units: false
boundary condition: true
name: SLC25A2
is: Q9BXI2
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:83884
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_69fb0ea2_8993_4eb9_878b_2a40b8140c24
has only substance units: false
constant: false
name: B4GALT2
is encoded by: hsa:8704
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM CE2433 m
constant: false
boundary condition: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
is: CHEBI:57795
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR SO4tl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
name: Sulfate transport (lysosome)
product: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110014#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_8d90561f_ddd3_47f6_8bf6_b6c96f9ba30b
is encoded by: hsa:6822
boundary condition: true
is: Q06520
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
constant: false
name: SULT2A1

metaM chsterol l
name: cholesterol
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:16113
is: HMDB00067
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187

metaR r1690
reactant: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110014#_87769fee_68e7_45d9_a555_eb15df219307
is encoded by: hsa:6817
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: SULT1A1

metaM ocdcea r
name: octadecenoate (n-C18:1)
has only substance units: false
is: SBO:0000247
is: HMDB00207
initial concentration: 1.0
notes: FORMULA: C18H33O2 CHARGE: -1
is: CHEBI:0
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: C00712

metaR r1818
product: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110014#
is: SBO:0000185
reactant: MODEL1310110014#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110014#
fast: false

metaR C4STMO2r
modifier: MODEL1310110014#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.170
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.72
kinetic law: MODEL1310110014#
name: C-4 methyl sterol oxidase
product: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR SQLSr
reversible: false
kinetic law: MODEL1310110014#
fast: false
modifier: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.5.1.21
is: SBO:0000176
is described by: ECO:0000134
name: Squalene synthase
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
product: MODEL1310110014#

metaR VALTAm
is version of: http://identifiers.org/ec-code/2.6.1.42
reversible: true
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
kinetic law: MODEL1310110014#
name: valine transaminase, mitochondiral
product: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
fast: false
is: SBO:0000176
modifier: MODEL1310110014#
is described by: ECO:0000269

metaM hLkynr c
constant: false
name: 3-hydroxy-L-kynurenine
initial amount: NaN
is: HMDB11631
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17380
boundary condition: false
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
has only substance units: false
type: Species

metaM m2emgacpail hs r
initial concentration: 1.0
is: C00080
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
constant: false
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/3380
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
is: CHEBI:24636
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_a661f4ce_49db_45c9_91e7_8855ca3fe4d6
boundary condition: true
is encoded by: hsa:2720
is: P16278
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial concentration: NaN
name: GLB1

metaR r1691
kinetic law: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110014#_0fa80adb_888f_49b4_93ec_3e122d122cc6
has only substance units: false
type: Species
is encoded by: hsa:3613
is: O14732
name: IMPA2
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true

metaM 5aop m
is: HMDB01149
constant: false
boundary condition: false
is: C00430
name: 5-Amino-4-oxopentanoate
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:17549

metaR UPP3S
name: uroporphyrinogen-III synthase
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/4.2.1.75
notes: GENE_ASSOCIATION: (7390.1) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.75 Confidence Level: 0 AUTHORS: PMID:3174619 NOTES:
product: MODEL1310110014#
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110014#
is described by: ECO:0000000
type: Reaction

metaR PYRt2p
is: SBO:0000185
reversible: true
reactant: MODEL1310110014#
fast: false
is described by: ECO:0000269
name: pyruvate peroxisomal transport via proton symport
kinetic law: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12705896,PMID:12739169,PMID:9786900 NOTES:NCD
type: Reaction
modifier: MODEL1310110014#

metaM pail45p hs c
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: SBO:0000247
is: CHEBI:28910
name: phosphatidylinositol 4,5-bisphosphate
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_ae9b4d8c_47ec_4de0_8d21_b186550653a6
name: ACOT6
is encoded by: hsa:641372
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q3I5F7
constant: false
initial amount: NaN

metaR GLYAMDTRc
notes: GENE_ASSOCIATION: (2628.1) SUBSYSTEM: Urea cycle EC Number: 2.1.4.1 Confidence Level: 4 AUTHORS: PMID:8547310 NOTES:SAB c
is described by: ECO:0000269
kinetic law: MODEL1310110014#
name: glycine amidinotransferase (c)
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.4.1
modifier: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
is: SBO:0000176
product: MODEL1310110014#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_metaM_acglcgalacglcgal14acglcgalgluside_hs_g
is: CHEBI:26174
name: (Gal)3 (Glc)1 (GlcNAc)3 (Cer)1
has only substance units: false
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_68d80b84_7f6d_4b16_a0c7_648e94a12eb5
initial concentration: NaN
is: Q6IBC4
type: Species
is encoded by: hsa:4726
has only substance units: false
name: NDUFS6
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_8cb0449b_8dae_45cb_a6bb_05a8523bb3a6
initial concentration: NaN
is: P30084
boundary condition: true
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
name: ECHS1
is encoded by: hsa:1892

metaR RE2985X
modifier: MODEL1310110014#
reversible: false
type: Reaction
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.17.99.3
fast: false
name: RE2985
is: SBO:0000176
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (8310.1) or (8309.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110014#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR GLCNACASE1ly
modifier: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.50
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110014#
reversible: false
name: alpha-N-acetylglucosaminidase, lysosomal
fast: false

metaR CRNtx
product: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
name: carnitine transport peroxisome to mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
fast: false

metaM cmpacna g
is: HMDB01176
initial concentration: 1.0
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
name: CMP-N-acetyl-beta-neuraminate(2-)
is: CHEBI:57812
boundary condition: false
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM pail45p hs n
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
type: Species
name: phosphatidylinositol 4,5-bisphosphate
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:28910
boundary condition: false
constant: false

metaR biomass reaction
reactant: MODEL1310110014#
reversible: false
is described by: ECO:0000134
name: biomass_reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110014#
type: Reaction
fast: false
product: MODEL1310110014#

metaM crm hs c
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: CHEBI:52639
type: Species
name: N-acylsphingosine
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_c0f66827_8ea7_4fcd_b60f_32ed3c8ae594
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
name: ALDH9A1
boundary condition: true
initial amount: NaN
is encoded by: hsa:223
is: P49189
type: Species

metaM ala B e
type: Species
initial concentration: 1.0
is: CHEBI:16958
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00056
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
constant: false
name: beta-alanine

metaM arachcrn c
initial amount: NaN
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
name: arachidyl carnitine
boundary condition: false
constant: false
is: HMDB06460
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM 3m4hpga m
constant: false
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
is: http://identifiers.org/pubchem.compound/7909
is: HMDB04061
type: Species
has only substance units: false
is: C05583
boundary condition: false

metaR B3GNT39g
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
modifier: MODEL1310110014#
reversible: false
kinetic law: MODEL1310110014#
type: Reaction

metaM tolbutamide c
constant: false
name: tolbutamide
initial amount: NaN
is: CHEBI:27999
type: Species
is: SBO:0000247
is: C07148
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C12H18N2O3S CHARGE: 0 INCHI: InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)

http://identifiers.org/biomodels.db/MODEL1310110014#_8b46c16b_368d_4be9_b815_d8e380fd51f4
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI640625
name: _AI640625_1_c
has only substance units: false
initial concentration: NaN

metaM HC02203 c
constant: false
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial concentration: 1.0
initial amount: NaN
name: prostaglandin-a2
is: SBO:0000247
is: CHEBI:27820
boundary condition: false
has only substance units: false

metaR GHMT2r
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.1.2.1
reactant: MODEL1310110014#
fast: false
is described by: ECO:0000269
name: glycine hydroxymethyltransferase, reversible
product: MODEL1310110014#
reversible: true
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110014#_21d61c5e_fe88_497f_b004_4fcc4123903d
initial amount: NaN
type: Species
is: E9PB82
constant: false
is encoded by: hsa:3295
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: HSD17B4

metaR RE3004M
type: Reaction
reactant: MODEL1310110014#
reversible: true
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110014#
name: RE3004
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
modifier: MODEL1310110014#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110014#_f6b0446c_6186_404e_8eca_d017d50e329d
type: Species
name: _U37519_1_c
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:U37519
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_62563a5a_9919_4dc0_9b32_3c9dd11f4db9
name: GBE1
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is: Q04446
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2632

http://identifiers.org/biomodels.db/MODEL1310110014#_9cdbc7a0_8b89_4cdf_af07_cbd557f2a6a3
is: P19404
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
name: NDUFV2
constant: false
type: Species
is encoded by: hsa:4729
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_590a0975_2843_44d9_be22_27220850a230
name: SGPL1
is encoded by: hsa:8879
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is: O95470

metaR FAOXC80
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
reversible: false
name: Beta oxidation of med/long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_41ee56b6_5891_4403_b262_deeca2fe0e58
is: P46721
constant: false
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6579
name: SLCO1A2
initial concentration: NaN

metaM HC02187 e
is: CHEBI:28774
name: reverse-triiodthyronine
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
type: Species

metaM CE5114 x
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,20-21,28-30,34-36,40,51-52H,4-7,10,13,16-19,22-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,21-20+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE5114
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:57923
name: trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA

metaR r2061
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110014#
reactant: MODEL1310110014#

metaR r0173
type: Reaction
product: MODEL1310110014#
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (3704.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:12042361,PMID:17045662,PMID:7449128,PMID:9927705 NOTES:
is: SBO:0000176
reversible: true
name: (S)-Lactate:NAD+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.1.1.27
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.19
is described by: ECO:0000000

metaM 3thexddcoacrn e
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
constant: false
is: HMDB02014
has only substance units: false
notes: FORMULA: C23H41NO5 CHARGE: 0
initial concentration: 1.0
type: Species

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

metaM crm hs e
has only substance units: false
initial amount: NaN
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:52639
name: N-acylsphingosine
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_5f52a6a7_7f3c_41fa_bb54_0fffce5098c1
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
name: PRDX1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5052
type: Species

metaM Tn antigen g
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: C04383
boundary condition: false
constant: false
type: Species
notes: FORMULA: C8H14NO5X CHARGE: 0
name: Tn antigen
initial concentration: 1.0

metaM ala B c
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:16958
has only substance units: false
boundary condition: false
name: beta-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
initial amount: NaN
is: HMDB00056
is: SBO:0000247

metaR ADKd
product: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000269
reactant: MODEL1310110014#
reversible: true
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
modifier: MODEL1310110014#
name: adenylate kinase (d form)
fast: false
type: Reaction

metaM ksi deg40 l
notes: FORMULA: C40H68N2O31 CHARGE: 0
initial concentration: 1.0
is: HMDB00143
constant: false
is: CHEBI:12936
type: Species
has only substance units: false
name: keratan sulfate I, degradation product 40
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_dce2f50d_6063_47fb_8019_53c5d8497fe8
is encoded by: hsa:1632
type: Species
is: SBO:0000252
initial amount: NaN
is: P42126
constant: false
boundary condition: true
initial concentration: NaN
name: ECI1
has only substance units: false

metaR PALFATPtc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

metaR APPNNte
is described by: ECO:0000000
type: Reaction
name: xenobiotic transport
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, xenobiotic transport (original and metabolized) NJ
reactant: MODEL1310110014#
product: MODEL1310110014#

metaR SUBERCACT
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberyl carnitine into cytosol
type: Reaction

metaR NACASPtm
is: SBO:0000185
kinetic law: MODEL1310110014#
reversible: false
product: MODEL1310110014#
is described by: ECO:0000000
name: N-acetyl-L-aspartate transport (mitochondria to cytosol)
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11279290 NOTES:MM
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_f14b603d_a404_4a6b_ae4b_1593b57bad5f
is: P17174
boundary condition: true
type: Species
name: GOT1
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:2805
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_37f670c2_949e_4fd6_8b6c_fcfaf1c5118a
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:8706
is: B3KTQ4
name: B3GALNT1

metaM HC02187 c
is: CHEBI:28774
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
constant: false
name: reverse-triiodthyronine
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR r1549
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110014#
is: SBO:0000185
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000000
reversible: true

metaM HC02203 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: prostaglandin-a2
is: SBO:0000247
is: CHEBI:27820
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_b9aaf477_c78a_4113_af88_ccdd0d2e9957
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3155
constant: false
is: SBO:0000252
is: Q6IBC0
type: Species
name: HMGCL
initial amount: NaN
has only substance units: false

metaM fuc12gal14acglcgalgluside hs g
is: CHEBI:57847
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C50H89N2O26FULLRCO CHARGE: 0
is: SBO:0000247
constant: false
is: HMDB00304
name: Type IIH glycolipid
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_f3d62bb5_2cc8_4bfe_8f20_de3769556358
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: ALDH1B1
is encoded by: hsa:219
is: P30837
has only substance units: false
constant: false

metaR MTHFDm
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.3
reactant: MODEL1310110014#
reversible: true
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.5.4.9
type: Reaction
is described by: ECO:0000269
product: MODEL1310110014#
is: SBO:0000176

metaR GALASE15ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
reactant: MODEL1310110014#
is: SBO:0000176
modifier: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110014#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR NACHEX14ly
fast: false
reversible: false
reactant: MODEL1310110014#
is: SBO:0000176
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
modifier: MODEL1310110014#
is described by: ECO:0000000
kinetic law: MODEL1310110014#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110014#_535aa6b8_6141_430a_a9b4_4dbd17274869
initial concentration: NaN
name: GSTZ1
constant: false
type: Species
is encoded by: hsa:2954
has only substance units: false
boundary condition: true
is: SBO:0000252
is: O43708
initial amount: NaN

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaM HC02207 c
initial concentration: 1.0
is: CHEBI:27555
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
has only substance units: false
type: Species
constant: false
boundary condition: false
name: prostaglandin-c2

metaR r0870
is described by: ECO:0000000
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
is version of: http://identifiers.org/ec-code/3.6.4.13
is version of: http://identifiers.org/ec-code/2.7.7.72
product: MODEL1310110014#
is: SBO:0000185
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.1
reversible: true
type: Reaction
name: Facilitated diffusion
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.3.4

http://identifiers.org/biomodels.db/MODEL1310110014#_d9c44bec_9efa_4163_b13d_4ee3e47735de
is encoded by: hsa:55350
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
name: VNN3
initial amount: NaN
initial concentration: NaN
constant: false

metaR G14T2g
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110014#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176

metaM hs deg20 l
constant: false
has only substance units: false
name: heparan sulfate, degradation product 20
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
type: Species
boundary condition: false
is: CHEBI:16126
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_1ba8c0c7_389d_4535_b531_96a9aa2c1617
boundary condition: true
is encoded by: hsa:56052
type: Species
initial concentration: NaN
is: Q9BT22
constant: false
initial amount: NaN
name: ALG1
has only substance units: false
is: SBO:0000252

metaM 3pg m
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
has only substance units: false
initial concentration: 1.0
is: CHEBI:58272
boundary condition: false
is: HMDB00807
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
is: SBO:0000247
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_c4ad47f6_a11e_4f13_b76f_06374f604b67
type: Species
is: Q5TDP6
initial concentration: NaN
constant: false
is encoded by: hsa:51557
has only substance units: false
name: LGSN
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM dc2coa x
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB01168
name: trans-Dec-2-enoyl-CoA
type: Species
initial concentration: 1.0
constant: false

metaM cs e deg1 l
initial concentration: 1.0
is: CHEBI:57737
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
has only substance units: false
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
is: HMDB00868
type: Species

metaM so3 c
initial concentration: 1.0
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: CHEBI:17137
name: Sulfite
has only substance units: false
is: C00094
is: HMDB00240

metaR TCHOLAte
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: true
product: MODEL1310110014#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: bile acid intracellular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

metaR EX adp
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adp exchange
type: Reaction

metaM galthcrm hs g
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:26174
notes: FORMULA: C42H76NO22FULLRCO CHARGE: 0
has only substance units: false
name: Gal-Gal-Gal-Glc-Cer
initial amount: NaN
is: SBO:0000247

metaR r0871
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409 NOTES:
kinetic law: MODEL1310110014#
name: Diffusion
is described by: ECO:0000000
reactant: MODEL1310110014#
reversible: true
fast: false
type: Reaction
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_346e4a4d_653d_4bd3_bcbe_fa24eb6e2b95
is: SBO:0000252
name: DDO
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:8528
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_metaM_fucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
type: Species
is: HMDB00257
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
is: CHEBI:16094
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
initial concentration: 1.0
initial amount: NaN

metaR DHEASULT
kinetic law: MODEL1310110014#
fast: false
is: SBO:0000176
reversible: false
type: Reaction
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.8.2.14
is described by: ECO:0000269
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.8.2.4
notes: GENE_ASSOCIATION: (6783.1) or (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:1588921 NOTES:NJ
product: MODEL1310110014#
name: Dehydroepiandrosterone sulfotransferase

metaR TMNDNCCRNt
reactant: MODEL1310110014#
reversible: false
is: SBO:0000185
type: Reaction
product: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110014#
fast: false
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110014#

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

metaR MTHGXLt
is: SBO:0000185
name: Methylglyoxal transport (cytosol to extracellular)
reversible: false
product: MODEL1310110014#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110014#_49b2265b_0091_496b_a820_8070ac6503a1
is encoded by: hsa:5052
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: PRDX1
is: Q06830
type: Species
has only substance units: false
initial concentration: NaN
constant: false

metaR CYTK5n
reversible: true
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000176
modifier: MODEL1310110014#
fast: false
is described by: ECO:0000269
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_8f9f7faf_ddb6_4df3_a620_446b7f0723d0
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR MELATNOX
is version of: http://identifiers.org/ec-code/1.14.14.1
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.14.13.48
fast: false
type: Reaction
is described by: ECO:0000269
reversible: false
is: SBO:0000176
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (1557.1) or (1543.1) or (1545.1) or (1544.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15616152 NOTES:SAB made up name
product: MODEL1310110014#
name: Melatonin:NADP oxidoreductase

metaM man r
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial amount: NaN
is: HMDB00169
type: Species
initial concentration: 1.0
name: D-mannose
is: CHEBI:16024
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_9528b8f5_8f6c_4173_b3dd_90a31e6f63ba
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: ALG2
initial concentration: NaN
type: Species
is encoded by: hsa:85365

metaM HC02207 e
type: Species
initial amount: NaN
is: CHEBI:27555
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
boundary condition: false
has only substance units: false
name: prostaglandin-c2
is: SBO:0000247
constant: false

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaM fadh2 r
is: CHEBI:58307
constant: false
name: FADH2(2-)
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
has only substance units: false
boundary condition: false
type: Species
is: HMDB01197
initial amount: NaN

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

metaR r0170
is version of: http://identifiers.org/ec-code/2.7.1.40
kinetic law: MODEL1310110014#
is described by: ECO:0000000
modifier: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
fast: false
is: SBO:0000176
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
reversible: true
product: MODEL1310110014#

metaR r1252
reactant: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
reversible: false
kinetic law: MODEL1310110014#
is described by: ECO:0000000
name: EC:6.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
is: SBO:0000176

metaR FAOXC184C164x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)x
type: Reaction

metaM c101coa c
name: decenoylcoa
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
initial amount: NaN
is: HMDB00651
has only substance units: false
type: Species
boundary condition: false

metaM odecrn c
boundary condition: false
initial amount: NaN
is: CHEBI:57394
is: C00412
initial concentration: 1.0
has only substance units: false
is: HMDB01114
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
constant: false
type: Species
name: octadecenoyl carnitine
is: SBO:0000247

metaM octdececoa m
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: octadecenoylcoa
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4

metaM dolp U r
initial amount: NaN
has only substance units: false
name: dolichyl phosphate(2-)
initial concentration: 1.0
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: SBO:0000247
is: CHEBI:57683
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_3ced3ff4_96c3_43da_aac0_40a0258888f7
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: E9PH29
has only substance units: false
is encoded by: hsa:10935
name: PRDX3

metaM chsterol c
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: HMDB00067
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:16113
type: Species
name: cholesterol

metaM cmpacna n
name: CMP-N-acetyl-beta-neuraminate(2-)
has only substance units: false
boundary condition: false
type: Species
constant: false
is: CHEBI:57812
initial concentration: 1.0
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial amount: NaN
is: SBO:0000247
is: HMDB01176

metaR S2TASE1ly
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.6.13
name: iduronate-2-sulfatase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110014#

metaM prostgh2 r
name: prostaglandin H2(1-)
type: Species
initial concentration: 1.0
is: HMDB01381
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: CHEBI:57405
boundary condition: false
initial amount: NaN

metaM cbasp e
notes: FORMULA: C5H6N2O5 CHARGE: -2
initial concentration: 1.0
is: C00438
has only substance units: false
constant: false
is: CHEBI:32814
is: HMDB00828
is: SBO:0000247
initial amount: NaN
name: N-Carbamoyl-L-aspartate
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_f6e2d771_526c_40ac_af7c_ddbafddcd4f1
constant: false
type: Species
name: PIGC
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5279
has only substance units: false
initial concentration: NaN

metaM pail45p hs m
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
is: CHEBI:28910
boundary condition: false
has only substance units: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial amount: NaN
name: phosphatidylinositol 4,5-bisphosphate

metaM tetd7ecoa m
has only substance units: false
is: HMDB13109
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
name: 7-tetradecenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110014#_2cec5962_ed51_4843_8d93_c9ef72595247
boundary condition: true
initial amount: NaN
is: Q13907
constant: false
name: IDI1
has only substance units: false
is encoded by: hsa:3422
is: SBO:0000252
initial concentration: NaN
type: Species

metaR MI14PP
name: inositol-1,4-bisphosphate 1-phosphatase
fast: false
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.57
product: MODEL1310110014#
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000269

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

metaR S6T9g
fast: false
is: SBO:0000176
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
is described by: ECO:0000000

metaM damp c
name: dAMP(2-)
is: CHEBI:58245
constant: false
is: HMDB00905
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360

metaR 4HGLSDm
product: MODEL1310110014#
is: SBO:0000176
reactant: MODEL1310110014#
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.12
is described by: ECO:0000212
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false

metaM ksii core2 e
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:17268
has only substance units: false
name: keratan sulfate II (core 2-linked)
boundary condition: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
initial amount: NaN
constant: false
is: HMDB00211

metaR PHYCBOXL
name: L-Phenylalanine carboxy-lyase
product: MODEL1310110014#
is described by: ECO:0000212
modifier: MODEL1310110014#
reactant: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
is version of: http://identifiers.org/ec-code/4.1.1.28
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110014#

metaM Lkynr c
initial concentration: 1.0
name: L-kynurenine
has only substance units: false
is: CHEBI:16946
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
is: HMDB00684

http://identifiers.org/biomodels.db/MODEL1310110014#_92891b01_faf9_4136_b1e2_3b2d856f7bc8
type: Species
has only substance units: false
name: NDUFB8
initial amount: NaN
is: SBO:0000252
constant: false
is: O95169
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4714

metaR r1544
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110014#
fast: false
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_5f25bc6b_e561_4252_889c_eb2de6fd9c3e
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:9963
name: SLC23A1
constant: false
has only substance units: false
type: Species

metaM crm hs l
name: N-acylsphingosine
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:52639

metaM 3hmbcoa m
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
initial amount: NaN
is: CHEBI:57312
type: Species
boundary condition: false
constant: false
has only substance units: false
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
is: HMDB01356

http://identifiers.org/biomodels.db/MODEL1310110014#_53950b65_9d38_4cf0_a4d7_2885fa90b2bf
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:100287639
name: _100287639_1_c
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_43cb1e68_b1db_4ccc_8f5b_f85369b75e5c
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
name: SPTLC1
has only substance units: false
constant: false
is: O15269
is encoded by: hsa:10558

metaR UDPGALtg
type: Reaction
modifier: MODEL1310110014#
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000269
is: SBO:0000185
name: UDP-Gal Golgi transport via CMP antiport
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
fast: false
reactant: MODEL1310110014#
reversible: true

metaR ALAtN1
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
name: Alanine transport (Na, H coupled)
reversible: true
fast: false
product: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827

metaR ASPTAm
name: aspartate transaminase
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
reversible: true
fast: false
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
is described by: ECO:0000269

metaR C60CPT1
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexanoylcarnitine
type: Reaction

metaR FAOXC122m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_76d211b9_9710_4cec_a354_30e49e95ce36
boundary condition: true
is: SBO:0000297
is encoded by: hsa:5281
constant: false
initial amount: NaN
has part: Q8TEQ8
type: Species
initial concentration: NaN
has only substance units: false
name: PIGF:PIGO
is encoded by: hsa:84720
has part: Q07326

http://identifiers.org/biomodels.db/MODEL1310110014#_bccf2ce2_71eb_4bb6_979d_c53b859a4087
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AF116616
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
name: _AF116616_1_m

http://identifiers.org/biomodels.db/MODEL1310110014#_770b084b_4b38_49d6_a36c_f6ba4bfe28d3
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:2509
name: _2509_1_e
constant: false
initial concentration: NaN

metaR S6TASE21ly
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
modifier: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
reversible: true
kinetic law: MODEL1310110014#

metaR S6TASE13ly
type: Reaction
reactant: MODEL1310110014#
is: SBO:0000176
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

metaM ksi deg38 l
is: SBO:0000247
is: HMDB00143
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:12936
notes: FORMULA: C54H91N3O41 CHARGE: 0
name: keratan sulfate I, degradation product 38
type: Species
initial amount: NaN
constant: false

metaR EX c81crn
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octenoyl carnitine
type: Reaction

metaR ACHEe
modifier: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
name: Acetylcholinesterase
is: SBO:0000176
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: false
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.7

metaR GLDBRAN
is version of: http://identifiers.org/ec-code/2.4.1.25
name: glycogen debranching enzyme
fast: false
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (178.4) or (178.5) or (178.1) or (178.3) or (178.2) or (178.6) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.33 Confidence Level: 4 AUTHORS: PMID:1374391 NOTES:lumped reaction, combination of 4-alpha-D-glucanotransferase (2.4.1.25) and amylo-alpha-1,6-glucosidase (3.2.1.33) NCD
reactant: MODEL1310110014#
type: Reaction
is: SBO:0000176
reversible: false

metaR RETNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110014#
is: SBO:0000185
name: retinoic acid transport
reactant: MODEL1310110014#
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_6796463d_32f3_4e60_9888_8a9b2b338f56
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: _AW299740_1_m
is encoded by: hsa:AW299740
type: Species
initial concentration: NaN
has only substance units: false
constant: false

metaR NACHEXA12ly
product: MODEL1310110014#
reversible: false
reactant: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
fast: false
kinetic law: MODEL1310110014#
name: beta-N-acetylhexosaminidase A, lysosomal
is: SBO:0000176

metaR DM 5hpet LPAREN r RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for 5(S)-HPETE(1-)
type: Reaction

metaM lnlncg e
has only substance units: false
is: CHEBI:32391
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
name: gamma-linolenate
is: HMDB03073
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_8dec8987_19e1_4c80_8c33_5052cdbdc779
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
name: HSD17B10
constant: false
is: Q99714
has only substance units: false
is encoded by: hsa:3028
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_a1c50318_6e43_4ec0_99ff_4a1d8cb0496b
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
name: GCK
is encoded by: hsa:2645
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_6b458e0a_b2e8_4e12_ac90_71201e4b3059
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:5287
initial concentration: NaN
is: O00750
initial amount: NaN
type: Species
is: SBO:0000252
name: PIK3C2B

metaM so3 m
type: Species
boundary condition: false
constant: false
is: HMDB00240
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
initial concentration: 1.0
is: CHEBI:17137
has only substance units: false
initial amount: NaN
name: hydrogensulfite
is: SBO:0000247

metaR C4OHc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxybytyryl carnitinec
type: Reaction

metaM man l
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: HMDB00169
initial concentration: 1.0
is: CHEBI:16024
name: D-mannose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: SBO:0000247
constant: false

metaM fadh2 m
initial concentration: 1.0
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: CHEBI:58307
is: SBO:0000247
boundary condition: false
is: C01352
has only substance units: false
initial amount: NaN
name: Flavin adenine dinucleotide reduced
type: Species
is: HMDB01197
constant: false

metaM 3hddcoa c
initial amount: NaN
type: Species
is: HMDB00623
constant: false
name: (S)-3-Hydroxydodecanoyl-CoA
is: SBO:0000247
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR GALACGLCGALGBSIDEte
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110014#
product: MODEL1310110014#
name: galacglcgalgbside hs transport
kinetic law: MODEL1310110014#

metaM prostgh2 e
is: CHEBI:57405
type: Species
name: prostaglandin H2(1-)
is: HMDB01381
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_dcac5488_9961_410c_bd6c_4cbe1d1a0e94
constant: false
name: SLC35C1
initial amount: NaN
initial concentration: NaN
is: B3KQH0
is encoded by: hsa:55343
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

metaM estradiol c
is: CHEBI:16469
initial amount: NaN
name: estradiol
constant: false
boundary condition: false
has only substance units: false
is: HMDB00151
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951

metaR 4MTOLBUTAMIDEte
name: xenobiotic transport
product: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: true
is: SBO:0000185
reactant: MODEL1310110014#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ

metaR r1548
reversible: true
type: Reaction
kinetic law: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_7d025e95_a909_4c0d_86a2_1e668569a7bb
type: Species
is: B4DGA9
initial concentration: NaN
constant: false
is: SBO:0000252
name: SLCO2B1
has only substance units: false
initial amount: NaN
is encoded by: hsa:11309
boundary condition: true

metaR PIACGT
is version of: http://identifiers.org/ec-code/2.4.1.198
reactant: MODEL1310110014#
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.83
reversible: false
fast: false
is described by: ECO:0000000
modifier: MODEL1310110014#
name: phosphatidylinositol N-acetylglucosaminyltransferase
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…

metaR THBPT4ACAMDASE
product: MODEL1310110014#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
modifier: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
reversible: false
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase

metaM crvnc c
is: HMDB02183
initial amount: NaN
is: SBO:0000247
name: cervonic acid, C22:6 n-3
boundary condition: false
is: CHEBI:36005
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C22H31O2 CHARGE: -1

metaM ksi deg11 l
initial concentration: 1.0
is: CHEBI:12936
is: HMDB00143
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
name: keratan sulfate I, degradation product 11
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_415e77b8_b6ec_48a2_bfa9_095d4d9ca45d
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:1571
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P05181
boundary condition: true
name: CYP2E1

metaR AG13T2g
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110014#
type: Reaction
reversible: false
modifier: MODEL1310110014#
product: MODEL1310110014#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110014#

metaM nh4 c
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
name: Ammonium
has only substance units: false
is: HMDB00051
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: C01342
boundary condition: false
is: SBO:0000247
is: CHEBI:28938

http://identifiers.org/biomodels.db/MODEL1310110014#_cd3b50eb_a3c6_4c3d_9a58_0a516e2444c0
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9517
is: O15270
type: Species
has only substance units: false
initial amount: NaN
name: SPTLC2
initial concentration: NaN

metaR MG1er
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110014#
reversible: false
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.106
is described by: ECO:0000000
modifier: MODEL1310110014#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_6bf3b0ff_dcbb_44f2_aecc_f35ed7c448d3
has part: Q14442
is encoded by: hsa:5283
has part: B3KUV7
is encoded by: hsa:8818
has part: Q9BRB3
is encoded by: hsa:5277
initial concentration: NaN
constant: false
has part: O94777
has part: Q92535
boundary condition: true
is encoded by: hsa:5279
is: SBO:0000297
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:9091
is encoded by: hsa:51227
initial amount: NaN
type: Species
has only substance units: false

metaR 3HBCDm
type: Reaction
reversible: true
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000176
modifier: MODEL1310110014#
is described by: ECO:0000254
reactant: MODEL1310110014#
name: 3-hydroxybutyryl-CoA dehydratase, mitochondrial
notes: GENE_ASSOCIATION: (55268.1) SUBSYSTEM: Butanoate metabolism EC Number: 4.2.1.55 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:NCD. rat gene that is homologous to the human gene encodes for this activity
fast: false

metaR r0179
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.1.1.27
product: MODEL1310110014#
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
reactant: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000
fast: false
modifier: MODEL1310110014#
type: Reaction
reversible: true

metaM HC00319 c
initial concentration: 1.0
is: CHEBI:30794
type: Species
constant: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial amount: NaN
is: SBO:0000247
name: Malonate
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_09abd959_d92b_4c60_9b43_39da0fd05394
is encoded by: hsa:954
has only substance units: false
constant: false
name: ENTPD2
boundary condition: true
is: Q9Y5L3
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species

metaR NOt
product: MODEL1310110014#
name: NO transport (diffusion)
is: SBO:0000185
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)

metaR r1547
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110014#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR FAOXC2242046m
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
modifier: MODEL1310110014#
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
product: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110014#
is described by: ECO:0000000
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_8971f412_85db_4113_a389_6c75a5e37621
type: Species
is: P48735
is encoded by: hsa:3418
is: SBO:0000252
constant: false
initial concentration: NaN
name: IDH2
initial amount: NaN
has only substance units: false
boundary condition: true

metaR TSULt4 3
reactant: MODEL1310110014#
fast: false
name: thiosulfate transport via sodium symport
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
type: Reaction
product: MODEL1310110014#
is described by: ECO:0000269
reversible: true
is: SBO:0000185
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_67eb0610_5063_45cf_8760_de554b67db1a
has only substance units: false
constant: false
name: TSTA3
is encoded by: hsa:7264
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q13630

metaR 4HOXPACDOX NADP
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
fast: false
product: MODEL1310110014#
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
type: Reaction
is described by: ECO:0000304
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
reactant: MODEL1310110014#

metaM octdececoa c
is: SBO:0000247
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB06351
name: octadecenoylcoa
boundary condition: false
constant: false

metaR GTHP
is version of: http://identifiers.org/ec-code/1.11.1.12
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.11.1.15
kinetic law: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.9
product: MODEL1310110014#
reversible: true
name: glutathione peroxidase
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110014#

metaR r0879
product: MODEL1310110014#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110014#
fast: false
reversible: false
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
kinetic law: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaM c6dc c
has only substance units: false
is: HMDB00705
constant: false
initial concentration: 1.0
notes: FORMULA: C13H22NO6 CHARGE: -1
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
name: adipoyl carnitine

metaR r1546
kinetic law: MODEL1310110014#
reversible: true
is: SBO:0000185
reactant: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000

metaM crvnc e
notes: FORMULA: C22H31O2 CHARGE: -1
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: HMDB02183
has only substance units: false
is: CHEBI:36005
name: cervonic acid, C22:6 n-3
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_9ef40732_67e8_4ce1_9563_4fb3a72f5497
is: P03915
constant: false
is encoded by: hsa:4540
type: Species
has only substance units: false
initial amount: NaN
name: ND5
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM mi1p D c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
is: HMDB02985
is: CHEBI:58433
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
name: 1D-myo-inositol 1-phosphate(2-)

metaM dolmanp U r
type: Species
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
name: Dolichyl phosphate D-mannose, human uterine homolog
is: CHEBI:15809

metaR DOLMANP Uter
name: dolichol-phosphate mannose flippase (uterus)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is: SBO:0000185
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_c2bdc244_c90a_4a60_a1a6_942dbc762171
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4702
is: B1AM93
name: NDUFA8

metaM nh4 e
name: ammonium
initial amount: NaN
is: HMDB00051
has only substance units: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:28938

metaM crm hs r
is: CHEBI:52639
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: N-acylsphingosine
is: SBO:0000247
constant: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195

http://identifiers.org/biomodels.db/MODEL1310110014#_91ab1e72_75f3_4980_a780_846475745b69
initial amount: NaN
is: A0PJJ9
is encoded by: hsa:2686
has only substance units: false
boundary condition: true
constant: false
name: GGT7
initial concentration: NaN
type: Species
is: SBO:0000252

metaM ksii core2 g
is: SBO:0000247
is: HMDB03418
initial concentration: 1.0
is: CHEBI:16443
has only substance units: false
initial amount: NaN
name: keratan sulfate II (core 2-linked)
constant: false
boundary condition: false
type: Species
notes: FORMULA: C81H129N6O67S3X CHARGE: -4

metaM Tn antigen l
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C8H14NO5X CHARGE: 0
is: SBO:0000247
is: C04383
name: Tn antigen

http://identifiers.org/biomodels.db/MODEL1310110014#_87830681_0b46_4fa0_ae3a_0baa470f6b84
constant: false
has part: P37287
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:5277
is encoded by: hsa:8818

metaR PPD2CSPp
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110014#
product: MODEL1310110014#
name: PPD2CSPp
is: SBO:0000176
kinetic law: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM

metaM cs e deg5 l
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
constant: false
is: HMDB00868
initial amount: NaN
notes: FORMULA: C31H47NO35S3 CHARGE: -4
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57737
has only substance units: false
boundary condition: false

metaR LNLNCGt
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
product: MODEL1310110014#
fast: false
is: SBO:0000185
type: Reaction

metaR EX tetpent3 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-3 exchange
type: Reaction

metaM m3mpdol L c
initial concentration: 1.0
boundary condition: false
is: CHEBI:37632
initial amount: NaN
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human liver homolog
constant: false
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C1480H2428N20O370P20 CHARGE: -20

http://identifiers.org/biomodels.db/MODEL1310110014#_7bd7f67e_2127_4519_8f3f_c16ce39ff403
name: GPX1
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2876
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_42697831_dd23_4fbd_8335_29ce9b96d2ba
is encoded by: hsa:11041
name: B3GNT1
constant: false
boundary condition: true
initial concentration: NaN
is: O43505
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_8473090b_dca5_4c9d_85cd_1dd8aca7a407
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
name: ST3GAL3
initial amount: NaN
is encoded by: hsa:6487

http://identifiers.org/biomodels.db/MODEL1310110014#_95edca4d_537d_4f5b_95fe_560195504f79
is encoded by: hsa:23530
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: NNT
constant: false
has only substance units: false

metaM HC00664 c
name: D-tagatofuranose 6-phosphate(2-)
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-2-6(10)5(9)4(8)3(15-6)1-14-16(11,12)13/h3-5,7-10H,1-2H2,(H2,11,12,13)/p-2/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C01097
type: Species
is: CHEBI:58695

metaR EX ptdca LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentadecanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_f61cff3d_babd_43b5_ad14_e5fd9aaeb3cc
boundary condition: true
name: AKR1A1
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:10327
is: SBO:0000252

metaR DMATTx
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.1
is described by: ECO:0000134
fast: false
type: Reaction
reactant: MODEL1310110014#
reversible: false
name: dimethylallyltranstransferase
kinetic law: MODEL1310110014#
product: MODEL1310110014#

metaM arachcrn m
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
name: arachidyl carnitine
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB06460
boundary condition: false
initial amount: NaN

metaR r0178
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
type: Reaction
product: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
fast: false
is: SBO:0000176
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.5.1.21

metaM tolbutamide e
initial concentration: 1.0
notes: FORMULA: C12H18N2O3S CHARGE: 0 INCHI: InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
constant: false
is: C07148
boundary condition: false
initial amount: NaN
name: tolbutamide
type: Species
is: CHEBI:27999
has only substance units: false
is: SBO:0000247

metaM dadp n
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: CHEBI:57667
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
name: dADP(3-)
constant: false
initial concentration: 1.0
is: HMDB01508

metaR TYRt
name: L-tyrosine transport
reversible: true
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
modifier: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
is: SBO:0000185

metaR LPS2e
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110014#
name: lipase, extracellular
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.1.3
product: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.3 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:carbonyl and extra H accounted for in R group NJ
reversible: false

metaR CITL
is: SBO:0000176
type: Reaction
reactant: MODEL1310110014#
product: MODEL1310110014#
reversible: false
fast: false
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
is described by: ECO:0000000
modifier: MODEL1310110014#
name: Citrate lyase

http://identifiers.org/biomodels.db/MODEL1310110014#_bec3123f_cdb3_442e_a061_7f3cea68cac2
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: NaN
name: SLC2A13
is: SBO:0000252
is: Q96QE2
boundary condition: true
is encoded by: hsa:114134

metaM ksi deg18 l
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
has only substance units: false
constant: false
name: keratan sulfate I, degradation product 18
is: HMDB00143
is: CHEBI:12936
is: SBO:0000247
boundary condition: false

metaM 3hexdtetcoa m
is: HMDB02288
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
name: 3,7,10,13-hexadecatetraenoylcoa
constant: false

metaM carveol c
is: HMDB03450
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: CHEBI:15389
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H16O CHARGE: 0 INCHI: InChI=1S/C10H16O/c1-7(2)9-5-4-8(3)10(11)6-9/h4,9-11H,1,5-6H2,2-3H3/t9-,10+/m1/s1 EHMN_ABBREVIATION: C00964
is: SBO:0000247
name: (-)-trans-carveol

http://identifiers.org/biomodels.db/MODEL1310110014#_00e9ed56_3e25_4095_ad3a_002d250abc0a
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q59EH3
name: ACP1
type: Species
is encoded by: hsa:52

http://identifiers.org/biomodels.db/MODEL1310110014#_f12412a6_0229_4c68_876e_fbf9a7273c20
initial amount: NaN
boundary condition: true
is encoded by: hsa:6582
initial concentration: NaN
name: SLC22A2
has only substance units: false
type: Species
constant: false
is: SBO:0000252

metaM ksi deg20 l
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00143
is: CHEBI:12936
is: SBO:0000247
name: keratan sulfate I, degradation product 20
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_ae288b44_aa7f_4f8d_99c6_ce13c3a6ed4e
is encoded by: hsa:221823
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P21108
boundary condition: true
type: Species
name: PRPS1L1
constant: false
initial amount: NaN

metaR FUCASEe
modifier: MODEL1310110014#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.51
product: MODEL1310110014#
is described by: ECO:0000000
kinetic law: MODEL1310110014#
type: Reaction
fast: false
name: alpha-fucosidase, extracellular
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176

metaM 3docopencoa m
has only substance units: false
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
constant: false
initial amount: NaN
boundary condition: false
name: 3,7,10,13,16-docosapentenoylcoa
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_3fdb49b4_4663_4948_bd2c_4499f182ccf6
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q99884
boundary condition: true
is encoded by: hsa:6534
has only substance units: false
initial amount: NaN
constant: false
name: SLC6A7

metaR r2359
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110014#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110014#
type: Reaction
name: Organic anion transporter 5 Utilized transport
reversible: true
kinetic law: MODEL1310110014#

metaM lneldc e
boundary condition: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
has only substance units: false
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB06270
name: linoelaidic acid (all trans C18:2)

http://identifiers.org/biomodels.db/MODEL1310110014#_1fcb6804_399f_40f3_a5c2_6cb106741870
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
name: GGT2
is: SBO:0000252
is encoded by: hsa:728441

metaR ADK1
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: adenylate kinase
product: MODEL1310110014#
reversible: true
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.4.3
modifier: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
fast: false

metaR HDECEACBP
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecenoylcoa from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_6897e978_7ea5_44b6_bab1_ff19cea0d4c7
initial amount: NaN
initial concentration: NaN
is: Q8TD20
is encoded by: hsa:154091
type: Species
name: SLC2A12
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_8730759f_1734_4729_aa56_679ea4e33370
type: Species
constant: false
initial concentration: NaN
name: RDH14
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:57665
is: Q9HBH5
initial amount: NaN

metaM xol7ah c
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
is: SBO:0000247
initial concentration: 1.0
name: 7alpha-hydroxy-5beta-cholestan-3-one
type: Species
is: HMDB06892
is: CHEBI:2290
initial amount: NaN

metaR SPHS1Pte
name: sphingosine-1-phosphate transport
product: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110014#_1843c0c0_1cdb_437a_b6af_60f26994095c
is encoded by: hsa:5161
is encoded by: hsa:1737
initial concentration: NaN
is encoded by: hsa:5162
has part: Q86YI5
boundary condition: true
is: SBO:0000297
name: DLAT:DLD:PDHA2:PDHB:PDHX
has only substance units: false
type: Species
has part: P11177
constant: false
has part: P29803
initial amount: NaN

metaR KSIt
is: SBO:0000185
product: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: false
reactant: MODEL1310110014#
name: keratan sulfate I transport, golgi to extracellular
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
fast: false

metaM asp D e
name: D-aspartate(1-)
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
is: CHEBI:29990
is: HMDB06483
boundary condition: false

metaR PPAt
name: Propionate transport, diffusion
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
is described by: ECO:0000000
reactant: MODEL1310110014#

metaM dtmp m
is: HMDB01227
is: CHEBI:26999
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: C00364
has only substance units: false
is: SBO:0000247
name: dTMP
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364

metaM ha pre1 e
name: hyaluronan biosynthesis, precursor 1
has only substance units: false
is: SBO:0000247
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: CHEBI:16126
initial concentration: 1.0

metaM apoC m
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: Apocarboxlase (no lys residue)
is: CHEBI:32551
type: Species
notes: FORMULA: XH CHARGE: 0
constant: false
is: HMDB00182
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_8b13b998_9588_43f9_9b18_28a7177389d9
boundary condition: true
has only substance units: false
is: Q9P2T1
type: Species
initial concentration: NaN
is: SBO:0000252
name: GMPR2
initial amount: NaN
constant: false
is encoded by: hsa:51292

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_e064a8e8_f50a_4b97_b32e_3e72747946c9
has only substance units: false
constant: false
name: CA5A
boundary condition: true
is: P35218
is encoded by: hsa:763
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252

metaR C141OHe
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:1-OH
type: Reaction

metaR FATP1t
name: fatty acid electroneutral transport
type: Reaction
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
is: SBO:0000185
product: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
is described by: ECO:0000269
reversible: true

metaM ksii core2 deg4 l
has only substance units: false
is: HMDB00812
initial amount: NaN
notes: FORMULA: C58H95N5O43SX CHARGE: -1
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:16953
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 4

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaM ins c
is: HMDB00195
is: CHEBI:17596
name: Inosine
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
type: Species
is: SBO:0000247
is: C00294
boundary condition: false

metaR EX tetpent6 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-6 exchange
type: Reaction

metaR ACACt2
type: Reaction
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
reactant: MODEL1310110014#
is: SBO:0000185
kinetic law: MODEL1310110014#
reversible: true
is described by: ECO:0000269
fast: false
product: MODEL1310110014#
name: acetoacetate transport via proton symport

metaR EX htaxol LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hydroxylated taxol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_640a4c9e_e9bd_4731_ad77_21fe3dea8a0f
boundary condition: true
is: Q9UMR5
initial amount: NaN
is encoded by: hsa:9374
has only substance units: false
constant: false
is: SBO:0000252
name: PPT2
type: Species
initial concentration: NaN

metaM ksi deg21 l
initial concentration: 1.0
constant: false
is: CHEBI:12936
boundary condition: false
is: HMDB00143
is: SBO:0000247
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
name: keratan sulfate I, degradation product 21
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_63eacd68_bf2d_4e61_8fe3_0dc2957faacf
name: MTHFS
is encoded by: hsa:10588
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P49914
type: Species
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_f3dc506f_344b_4774_a6a5_73cf4a552845
name: IMPA1
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is: B7Z6Q4
is encoded by: hsa:3612
initial concentration: NaN
constant: false

metaR DLNLCGCRNt
product: MODEL1310110014#
kinetic law: MODEL1310110014#
name: transport into the mitochondria (carnitine)
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110014#
is: SBO:0000185
reversible: false
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_aadf8152_b70e_4711_8f14_9465d710bd91
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: SLC2A3
initial amount: NaN
is encoded by: hsa:6515
constant: false
is: P11169
has only substance units: false
type: Species

metaM hs deg6 l
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB01352
is: CHEBI:17180
type: Species
initial concentration: 1.0
name: heparan sulfate, degradation product 6
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_538bd4ea_2460_4276_ad09_39774a419cd4
name: _AI345944_1_m
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI345944
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false

metaM octe5coa m
initial concentration: 1.0
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
name: 5-octenoylcoa
is: SBO:0000247
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_9d04167f_593e_437e_a8d0_ac5c41df51ad
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:3628
is: SBO:0000252
boundary condition: true
name: INPP1
is: P49441

metaM ksi pre21 g
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
is: HMDB00175
is: C00130
constant: false
type: Species
is: CHEBI:58053
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 21
boundary condition: false

metaR RE3624M
reversible: false
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000000
name: RE3624
fast: false
is: SBO:0000176
product: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110014#_8616a9c7_e0e9_47c3_8b30_22e6019ef970
name: _NM_001929_1_c
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:NM 001929

http://identifiers.org/biomodels.db/MODEL1310110014#_133662b7_1681_4de6_a323_e0081c57a769
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4245
is: P26572
type: Species
initial amount: NaN
name: MGAT1

metaM adrncoa c
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205480
name: adrenyl coenzyme A
constant: false
initial concentration: 1.0
has only substance units: false
is: C16170
boundary condition: false
initial amount: NaN
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110014#_ecf895c5_9263_4077_a9a8_14e84d15eafa
type: Species
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:6546
name: SLC8A1
is: SBO:0000252
initial concentration: NaN
is: F6VPY9
initial amount: NaN

metaR GLCNACPT L
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.15
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: false
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (liver)
modifier: MODEL1310110014#

metaR FAOXC164m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_f5bee8c0_ad63_4c50_b99e_9e0102f82bd8
constant: false
initial concentration: NaN
is: B7Z428
boundary condition: true
initial amount: NaN
has only substance units: false
name: GNE
type: Species
is: SBO:0000252
is encoded by: hsa:10020

metaR r2356
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
fast: false
type: Reaction
product: MODEL1310110014#

metaM 3ddecdicoa x
type: Species
has only substance units: false
is: HMDB03952
is: SBO:0000247
is: C05280
initial amount: NaN
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
constant: false
name: 3,6-dodecadienoylcoa
initial concentration: 1.0

metaR C141OHc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecenoyl carnitine
type: Reaction

metaR CYTK14n
name: cytidylate kinase (dCMP,CTP),nuclear
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_6028ae99_ca15_480e_a06b_1db0bb6ba5ec
is encoded by: hsa:AA854479
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
name: _AA854479_1_m
boundary condition: true
is: SBO:0000252
type: Species

metaR RE1709N
reversible: true
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/4.2.1.96
is: SBO:0000176
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110014#
type: Reaction
modifier: MODEL1310110014#
fast: false
name: RE1709
kinetic law: MODEL1310110014#

metaR RE2677C
type: Reaction
reversible: false
name: RE2677
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:
product: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000

metaR r2355
reactant: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000185
fast: false
type: Reaction
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110014#_89954f8b_ddf0_4073_ac37_c6f3084dbfce
is encoded by: hsa:AI469183
constant: false
name: _AI469183_1_x
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_9bb5ce72_f420_4263_b6ca_4539a1088cb3
is: SBO:0000252
name: DGKE
is encoded by: hsa:8526
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: A1L4Q0

metaM ins e
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: C00294
name: Inosine
is: HMDB00195
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
has only substance units: false
is: SBO:0000247
is: CHEBI:17596
initial concentration: 1.0

metaR RADH4
reactant: MODEL1310110014#
is described by: ECO:0000000
name: retinal dehydrogenase (NADPH)
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:11606944 NOTES:IT
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110014#
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_0d925d5e_9f5a_4784_bda8_a68f368c6382
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is: P54750
name: PDE1A
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:5136

metaM ksi pre17 g
initial concentration: 1.0
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 17
has only substance units: false
constant: false
is: CHEBI:28067
type: Species
is: SBO:0000247
boundary condition: false

metaR ALCD22 L
name: alcohol dehydrogenase (L-lactaldehyde)
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000304
reactant: MODEL1310110014#
fast: false
is version of: http://identifiers.org/ec-code/1.1.99.24
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.1
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (126.1) or (137872.1) or (126.1 and 124.1) or (127.1) or (130.1) or (284273.1) or (125.1 and 124.1) or (128.1) or (124.1) or (125.1) or (284273.2) or (131.1) or (125.1 and 126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
reversible: false
is: SBO:0000176

metaR FAOXC16180m
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
reversible: false
reactant: MODEL1310110014#
modifier: MODEL1310110014#
product: MODEL1310110014#
name: Beta oxidation fatty acid
type: Reaction
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110014#_2a306c43_2ebc_4c2e_82d3_f6643ad5718e
name: SLC6A9
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:6536
initial concentration: NaN
is: B7Z3W8
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_fc71a960_6e9d_4067_a385_6e35daad42a2
boundary condition: true
type: Species
is: P50224
name: SULT1A3
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:6818
is: SBO:0000252

metaR SERDGLNexR
is described by: ECO:0000304
name: D-Serine/Glutamine reversible exchange
reversible: true
is: SBO:0000185
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
fast: false

metaM 4nphsf c
initial concentration: 1.0
is: CHEBI:35422
has only substance units: false
name: 4-Nitrophenyl sulfate
boundary condition: false
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
initial amount: NaN
is: HMDB06492

metaR PI45P3Kn
reversible: false
product: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
name: phosphatidylinositol 4,5-bisphosphate 3-kinase, nuclear
fast: false
reactant: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110014#_cd176b81_74da_41f1_876c_06ad9757fae7
name: ODC1
is encoded by: hsa:4953
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is: P11926
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_2e61ef6e_7c3f_4910_81d7_598b252979c2
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: ALDH1B1
type: Species
is encoded by: hsa:219
is: P30837
is: SBO:0000252
constant: false
boundary condition: true

metaR r1551
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110014#
fast: false
reactant: MODEL1310110014#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110014#
is: SBO:0000185
type: Reaction

metaM dgdp c
boundary condition: false
is: CHEBI:58595
is: C00361
name: dGDP
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00960
constant: false
initial concentration: 1.0

metaR r2358
product: MODEL1310110014#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
fast: false

metaM xol7ah2al m
is: HMDB06894
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:27428
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
constant: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
has only substance units: false
is: SBO:0000247
type: Species

metaR TCHOLAt3
product: MODEL1310110014#
fast: false
name: ABC bile acid transporter
reversible: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (8714.3) or (8647.1) or (8714.2) or (8714.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9738950,PMID:9806540,PMID:9813153 NOTES:for bile acid secretion into bile NJ
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000269

metaM em2emgacpail hs r
constant: false
type: Species
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
boundary condition: false
has only substance units: false
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
is: HMDB03125
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16240

metaR FAOXC101m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

metaM carveol e
has only substance units: false
notes: FORMULA: C10H16O CHARGE: 0 INCHI: InChI=1S/C10H16O/c1-7(2)9-5-4-8(3)10(11)6-9/h4,9-11H,1,5-6H2,2-3H3/t9-,10+/m1/s1 EHMN_ABBREVIATION: C00964
boundary condition: false
is: CHEBI:15389
is: SBO:0000247
name: (-)-trans-carveol
type: Species
constant: false
is: HMDB03450
initial concentration: 1.0
initial amount: NaN

metaR EX 34dhoxpeg LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxyphenylethyleneglycol exchange
type: Reaction

metaM q10 m
initial amount: NaN
name: ubiquinone-10
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:46245
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
boundary condition: false
is: SBO:0000247
is: HMDB01072
type: Species

metaR RE2677E
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
reversible: false
reactant: MODEL1310110014#
name: RE2677
is: SBO:0000176
is described by: ECO:0000000
fast: false
product: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction

metaR r1552
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110014#
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110014#

metaM prist c
boundary condition: false
name: pristanic acid
type: Species
is: CHEBI:51340
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00795
has only substance units: false
initial concentration: 1.0

metaR r2357
product: MODEL1310110014#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110014#
type: Reaction
reversible: true
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM dadp m
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
constant: false
is: HMDB01508
is: SBO:0000247
name: dADP(3-)
initial concentration: 1.0
is: CHEBI:57667
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false

metaM CE5162 r
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:57923
name: trans,cis-2,9-octadecadienoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110014#_44912199_a204_471c_94b1_831e261d7162
has part: O15254
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
name: EHHADH:ACAA1:HSD17B4:ACOX3
is encoded by: hsa:8310
type: Species
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110014#_7d088280_5a60_4c00_b254_4f17686f3a0f
has only substance units: false
name: HAO2
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:51179
initial concentration: NaN

metaR FAOXC204C205x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C20:5)x
type: Reaction

metaR r0434
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is described by: ECO:0000000
product: MODEL1310110014#
is: SBO:0000176
fast: false
modifier: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
type: Reaction
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#

metaM asp D c
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
is: CHEBI:29990
is: HMDB06483
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
name: D-aspartate(1-)

http://identifiers.org/biomodels.db/MODEL1310110014#_97eecad6_d974_4d9d_b064_13dc6e007633
name: _22305_2_c
type: Species
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:22305
has only substance units: false

metaM 4nphsf e
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
initial concentration: 1.0
is: CHEBI:35422
is: SBO:0000247
constant: false
has only substance units: false
name: 4-Nitrophenyl sulfate
type: Species
boundary condition: false
initial amount: NaN
is: HMDB06492

http://identifiers.org/biomodels.db/MODEL1310110014#_deddba5a_8263_440a_ad36_14015fb21f0e
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: _AA419122_1_c
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:AA419122

metaR METAT
reversible: false
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (4143.1) or (27430.2 and 4144.1) or (27430.1 and 4144.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110014#
fast: false
product: MODEL1310110014#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110014#
name: methionine adenosyltransferase
is version of: http://identifiers.org/ec-code/2.5.1.6

metaR S23T4g
reactant: MODEL1310110014#
product: MODEL1310110014#
name: beta-galactoside alpha-2,3-sialyltransferase
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.99.4

http://identifiers.org/biomodels.db/MODEL1310110014#_3ac41e4f_ca72_446d_b175_2af1d59be6d8
initial concentration: NaN
is: SBO:0000252
is: Q8IWW8
constant: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:137872
name: ADHFE1
has only substance units: false

metaM btcoa m
initial amount: NaN
type: Species
name: Butanoyl-CoA
constant: false
is: C00136
is: CHEBI:57371
initial concentration: 1.0
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
is: HMDB01088
has only substance units: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_61b4cbf1_83fe_4245_bd73_0a3b3984689f
is: Q9P0J0
boundary condition: true
initial amount: NaN
name: NDUFA13
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:51079

http://identifiers.org/biomodels.db/MODEL1310110014#_d61cacff_1ae7_44df_8b31_67c7e1ce3cb7
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:191
initial amount: NaN
is: B3KUN3
name: AHCY
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_1272c73c_e424_44a5_a7eb_f47b545c999f
has only substance units: false
name: SOD2
type: Species
is encoded by: hsa:6648
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: P04179

metaR ACACT1rm
type: Reaction
product: MODEL1310110014#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.9
name: acetyl-CoA C-acetyltransferase, mitochondrial
kinetic law: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_4069324d_ea0a_4264_a8fa_ed77ae2e9483
constant: false
is encoded by: hsa:3141
initial concentration: NaN
is: SBO:0000252
is: P50747
boundary condition: true
name: HLCS
type: Species
has only substance units: false
initial amount: NaN

metaM xol7ah2al c
initial concentration: 1.0
type: Species
is: HMDB06894
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:27428
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
constant: false
is: SBO:0000247

metaM ura c
type: Species
name: Uracil
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: HMDB00300
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: C00106
is: CHEBI:17568
is: SBO:0000247
has only substance units: false

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

metaR r0437
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
product: MODEL1310110014#
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/4.1.2.13
reactant: MODEL1310110014#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21

metaM occoa c
boundary condition: false
is: SBO:0000247
is: HMDB01070
name: Octanoyl-CoA (n-C8:0CoA)
initial amount: NaN
is: C01944
type: Species
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: CHEBI:57386
initial concentration: 1.0
constant: false
has only substance units: false

metaR MTHFD2
product: MODEL1310110014#
name: methylenetetrahydrofolate dehydrogenase (NAD)
reactant: MODEL1310110014#
reversible: true
kinetic law: MODEL1310110014#
fast: false
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.5.4.9
is: SBO:0000176

metaM apoC c
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: HMDB03667
is: SBO:0000247
notes: FORMULA: XH CHARGE: 0
boundary condition: false
name: Apocarboxlase (no lys residue)
is: CHEBI:29060

metaR r0706
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
fast: false
reversible: false
is described by: ECO:0000000
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.99.10
is: SBO:0000176
type: Reaction

metaR r2352
kinetic law: MODEL1310110014#
type: Reaction
is: SBO:0000185
product: MODEL1310110014#
reversible: true
fast: false
reactant: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport

metaR ACOX22x
fast: false
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.17.99.3
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 2 AUTHORS: PMID:11181649 NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 analog as per KEGG added NJ
is described by: ECO:0000304
type: Reaction
is: SBO:0000176
reactant: MODEL1310110014#
reversible: false
name: acyl-Coenzyme A oxidase 2, branched chain
product: MODEL1310110014#
modifier: MODEL1310110014#

metaR MG2er
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
reversible: false
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
fast: false
is: SBO:0000176

metaR C6DCCACT
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of adipoyl carnitine into cytosol
type: Reaction

metaM dtmp c
constant: false
is: HMDB01227
type: Species
is: C00364
name: dTMP
is: SBO:0000247
has only substance units: false
is: CHEBI:26999
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364

http://identifiers.org/biomodels.db/MODEL1310110014#_25030304_9426_4906_83ef_ec6c5081e701
type: Species
initial concentration: NaN
is: Q5JAM2
boundary condition: true
is: SBO:0000252
has only substance units: false
name: ALAS1
initial amount: NaN
constant: false
is encoded by: hsa:211

metaR FADH2tx
type: Reaction
reactant: MODEL1310110014#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
product: MODEL1310110014#
reversible: true
name: FADH2 transporter, peroxisomal
is: SBO:0000185

metaM HC02217 e
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: prostaglandin-g2
constant: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
is: CHEBI:27647
initial amount: NaN
has only substance units: false

metaM nac c
name: Nicotinate
notes: FORMULA: C6H4NO2 CHARGE: -1
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:0
type: Species
initial amount: NaN
is: SBO:0000247
is: C00253
is: HMDB01488

http://identifiers.org/biomodels.db/MODEL1310110014#_107a6404_b989_4472_8b48_e70ea94758c3
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: Q9P019
is encoded by: hsa:29085
type: Species
initial amount: NaN
is: SBO:0000252
name: PHPT1

metaR FUMSO3tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false
is described by: ECO:0000269
reactant: MODEL1310110014#
modifier: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000185
type: Reaction
name: Fumarate:sulfite antiport, mitochondrial
kinetic law: MODEL1310110014#
reversible: true

metaM hdd2crn m
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
name: trans-Hexadec-2-enoyl carnitine
type: Species
is: HMDB06317

metaR r1401
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.35
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.41
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.1.3
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.51
kinetic law: MODEL1310110014#
name: Facilitated diffusion
fast: false
is version of: http://identifiers.org/ec-code/2.7.10.1
product: MODEL1310110014#

metaR S6TASE14ly
is described by: ECO:0000000
modifier: MODEL1310110014#
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
reactant: MODEL1310110014#
fast: false
reversible: true
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_783f4146_aea8_4122_b639_28b720fa9be2
initial amount: NaN
boundary condition: true
is encoded by: hsa:AA788780
type: Species
has only substance units: false
is: SBO:0000252
name: _AA788780_1_c
constant: false
initial concentration: NaN

metaM m2mn l
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
is: HMDB06537
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaM 5eipencoa m
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
name: 5,8,11,14,17-eicosapentenoylcoa
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
constant: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4

metaR TMNDNCt
is described by: ECO:0000000
product: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000185
name: fatty acid transport via diffusion
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110014#
reversible: true

metaR 34DHPHEt
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:NCD
is described by: ECO:0000269
reversible: true
product: MODEL1310110014#
is: SBO:0000185
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: 3,4-Dihydroxy-L-phenylalanine transport
modifier: MODEL1310110014#
type: Reaction
fast: false

metaM btcoa x
name: Butanoyl-CoA
initial amount: NaN
type: Species
is: HMDB01088
has only substance units: false
initial concentration: 1.0
constant: false
is: C00136
notes: FORMULA: C25H38N7O17P3S CHARGE: -4
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_cad28914_8df3_4e8c_ab8e_59cb54d930e8
boundary condition: true
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
name: GCH1
is encoded by: hsa:2643
is: Q8IZH9
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_121a88a2_c69e_4436_92a6_bb11809bf9c3
initial concentration: NaN
name: KHK
boundary condition: true
is: SBO:0000252
is: P50053
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:3795
constant: false

metaR AMANK
is version of: http://identifiers.org/ec-code/5.1.3.14
modifier: MODEL1310110014#
type: Reaction
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.1.59
name: N-acetyl-D-mannosamine kinase
is described by: ECO:0000269
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES:JLR - Kegg R02705

http://identifiers.org/biomodels.db/MODEL1310110014#_81830501_17e7_4e54_9780_f809ba25b230
initial amount: NaN
name: PDE1B
is: Q7Z364
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:5153
boundary condition: true
constant: false
is: SBO:0000252

metaR r2354
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is: SBO:0000185

metaR DCSPTN1CRNt
type: Reaction
product: MODEL1310110014#
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
reversible: false
is described by: ECO:0000269
is: SBO:0000185
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110014#
fast: false

metaR PCt
name: phosphatidylcholine transporter
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ
is version of: http://identifiers.org/ec-code/3.6.3.44
reactant: MODEL1310110014#
fast: false
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_0a9636af_16d1_4bfc_a999_22e37546b4f4
name: B3GALT5
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:10317
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM CE2838 e
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
constant: false
type: Species
is: C01936
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: maltononaose

metaR S4TASE3ly
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.6.12
name: N-acetylgalactosamine-4-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
modifier: MODEL1310110014#
fast: false
reversible: true
type: Reaction
is: SBO:0000176
product: MODEL1310110014#
is described by: ECO:0000000

metaM HC01501 c
has only substance units: false
initial concentration: 1.0
name: hydroxidodioxidosulfidosulfate(1-)
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:33539
boundary condition: false
notes: FORMULA: HO3S2 CHARGE: -1 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-1 EHMN_ABBREVIATION: C05529
constant: false

metaR C4STMO1r
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110014#
fast: false
type: Reaction
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.14.13.72
reversible: false
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
product: MODEL1310110014#

metaM adpac c
notes: FORMULA: C6H8O4 CHARGE: -2
initial concentration: 1.0
has only substance units: false
name: adipic acid
is: HMDB00448
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN

metaM dtmp e
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
type: Species
name: dTMP(2-)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:26999
is: HMDB01227

metaR FAOXC101x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)x
type: Reaction

metaR KAS8
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110014#
kinetic law: MODEL1310110014#
name: b-ketoacyl synthetase (palmitate, n-C16:0)
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
fast: false
type: Reaction

metaM HC02217 c
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:27647
name: prostaglandin-g2
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial amount: NaN
type: Species

metaR LDH L
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.1.1.27
reactant: MODEL1310110014#
fast: false
product: MODEL1310110014#
modifier: MODEL1310110014#
name: L-lactate dehydrogenase
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
is: SBO:0000176
type: Reaction

metaR IVCRNe
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of isovaleryl carnitine into the extra cellular space
type: Reaction

metaR TTDCAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
reversible: true
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110014#
is: SBO:0000185
kinetic law: MODEL1310110014#
fast: false
product: MODEL1310110014#
name: tetradecanoate (transport)

metaR DOLPMT4 Uer
type: Reaction
reactant: MODEL1310110014#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110014#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)

metaR r2353
reversible: true
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110014#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_1245bd39_b3e7_4dd9_9925_148ea2c1db9c
name: CPT1A
is: Q8WZ48
is encoded by: hsa:1374
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false

metaR r0010
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.6
type: Reaction
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (25841.1) or (847.1) SUBSYSTEM: ROS detoxification EC Number: 1.11.1.6 Confidence Level: 0 AUTHORS: PMID:12054464,PMID:1657986 NOTES:
name: hydrogen-peroxide:hydrogen-peroxide oxidoreductase EC:1.11.1.6
fast: false
is described by: ECO:0000000
reactant: MODEL1310110014#
reversible: false
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_dd15559c_432b_4d50_a51b_9d4367e2c1a9
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:8789
name: FBP2
has only substance units: false
boundary condition: true
constant: false
is: O00757

http://identifiers.org/biomodels.db/MODEL1310110014#_7bd0cce9_c313_41a6_82a0_2ececa48efb5
initial concentration: NaN
is: O95479
name: H6PD
boundary condition: true
is encoded by: hsa:9563
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_4e518d36_f0ca_48f2_9dd6_df060a48f8f5
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:AU149534
name: _AU149534_1_c
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_2a5cf3ad_8e7b_4167_91dc_c9883b4da077
initial amount: NaN
constant: false
is: Q92185
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6489
boundary condition: true
name: ST8SIA1
has only substance units: false

metaM 5adtststerone e
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
name: 17beta-hydroxy-5alpha-androstan-3-one
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:16330
is: HMDB02961

metaM chol m
name: choline
type: Species
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial concentration: 1.0
is: HMDB00097
is: SBO:0000247
has only substance units: false
is: CHEBI:15354

http://identifiers.org/biomodels.db/MODEL1310110014#_c8bb6581_4807_4bcb_9863_94d30c19471d
is: SBO:0000252
is encoded by: hsa:9152
constant: false
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: SLC6A5
is: Q9Y345

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaR GULN3D
fast: false
is: SBO:0000176
kinetic law: MODEL1310110014#
type: Reaction
name: L-gulonate 3-dehydrogenase
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110014#

metaM fe3 e
is: SBO:0000247
name: Fe3+
is: HMDB12943
is: CHEBI:29034
type: Species
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false

metaM CE5117 m
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
has only substance units: false
is: CHEBI:57923
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_6fe002bf_3bcf_4435_bf3f_1fce71a17d39
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
name: ACSS3
type: Species
is: Q9H6R3
is encoded by: hsa:79611
initial amount: NaN

metaR BTND1n
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.1.12
is: SBO:0000176
name: biotinidase (biotin), nuclear
type: Reaction
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
reversible: false
fast: false

metaM q10 c
has only substance units: false
constant: false
is: SBO:0000247
name: ubiquinone-10
is: HMDB01072
initial amount: NaN
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:46245

metaM anth c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: anthranilate
has only substance units: false
type: Species
constant: false
is: CHEBI:16567
boundary condition: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
is: HMDB01123

metaR M13N2Tg
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
type: Reaction
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.101
reactant: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_e5360a25_9281_4370_bff5_f52e7fbb8732
has only substance units: false
is: Q96FL9
constant: false
initial amount: NaN
name: GALNT14
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:79623
type: Species
boundary condition: true

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaR ABO7g
kinetic law: MODEL1310110014#
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
is version of: http://identifiers.org/ec-code/2.4.1.37
reversible: false
reactant: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110014#
is described by: ECO:0000269

metaR FAOXC123x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)x
type: Reaction

metaR ALCD22 D
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.1
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (126.1) or (137872.1) or (126.1 and 124.1) or (127.1) or (130.1) or (284273.1) or (125.1 and 124.1) or (128.1) or (124.1) or (125.1) or (284273.2) or (131.1) or (125.1 and 126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.78 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/1.1.99.24
modifier: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
name: alcohol dehydrogenase (D-lactaldehyde)
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110014#_76838efd_6f73_49d1_90dd_e2e56a83dbd3
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
name: SULT1A1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6817

metaM kynate c
initial concentration: 1.0
type: Species
is: HMDB00715
constant: false
name: kynurenate
is: CHEBI:58454
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
boundary condition: false
has only substance units: false

metaR B3GNT311g
product: MODEL1310110014#
is described by: ECO:0000254
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
fast: false
reactant: MODEL1310110014#
type: Reaction
is: SBO:0000176
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaR XYLTD Dr
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:
product: MODEL1310110014#
reactant: MODEL1310110014#
name: xylitol dehydrogenase (D-xyulose-forming)
kinetic law: MODEL1310110014#
fast: false
is: SBO:0000176

metaR CSPG Atly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110014#
reversible: false
is: SBO:0000185
name: chondroitin sulfate A transport, extracellular to lysosome
type: Reaction
fast: false
reactant: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000000

metaM 3hexdcrn c
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C23H45NO5 CHARGE: 0
name: 3-hydroxyhexadecanoylcarnitine
is: SBO:0000247
is: HMDB13336
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_4761620f_4fe2_418a_8d07_7d8d2378b42d
name: PPCDC
type: Species
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: Q96CD2
is: SBO:0000252
is encoded by: hsa:60490
initial amount: NaN

metaR C12DCACOT
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of dodecanedioyl coa for release into cytosol
type: Reaction

metaR r1117
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
name: Facilitated diffusion
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110014#_af4d747a_656a_4bcd_9185_a63f12feef59
is: P51648
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:224
constant: false
name: ALDH3A2
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM pydx c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: C00250
name: Pyridoxal
is: CHEBI:17310
has only substance units: false
type: Species
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
is: HMDB01545
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_e07385f2_b7b2_4e33_9609_5ead841ff263
initial concentration: NaN
has only substance units: false
name: SDHA
constant: false
is encoded by: hsa:6389
type: Species
is: P31040
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM 5adtststerone c
initial amount: NaN
constant: false
name: 17beta-hydroxy-5alpha-androstan-3-one
is: SBO:0000247
is: CHEBI:16330
has only substance units: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial concentration: 1.0
boundary condition: false
is: HMDB02961
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_8e797839_f10e_46f7_92be_16975626f532
is encoded by: hsa:4722
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: O75489
name: NDUFS3

metaM fe3 c
is: HMDB12943
has only substance units: false
type: Species
name: Fe3+
boundary condition: false
notes: FORMULA: Fe CHARGE: 3
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM q10 e
initial amount: NaN
type: Species
is: HMDB01072
name: ubiquinone-10
is: SBO:0000247
is: CHEBI:46245
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+

http://identifiers.org/biomodels.db/MODEL1310110014#_ffdd13b8_3c14_43fd_9b67_93a04d115f8d
is: Q9HAB8
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: PPCS
type: Species
is encoded by: hsa:79717
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_e6e842b6_f289_4ce6_8f78_ab713a6c7521
name: PIGF
initial concentration: NaN
is: SBO:0000252
is: Q07326
initial amount: NaN
is encoded by: hsa:5281
constant: false
boundary condition: true
has only substance units: false
type: Species

metaM 2mp2coa m
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27754
is: HMDB01011
is: SBO:0000247
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
has only substance units: false
type: Species
name: 2-Methylprop-2-enoyl-CoA
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_d80507c7_6813_4110_aa2c_14bb0c63ea90
initial amount: NaN
type: Species
has only substance units: false
is: Q3MHC9
is: SBO:0000252
is encoded by: hsa:23517
name: SKIV2L2
constant: false
initial concentration: NaN
boundary condition: true

metaR FAOXC163Gm
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_e39a94f8_fa67_4b19_a1ef_f1d594daa8d8
name: SLC24A4
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: Q8NFF2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:123041
constant: false

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaR PHCHGSm
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
is: SBO:0000176
type: Reaction
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
is described by: ECO:0000000
fast: false
reactant: MODEL1310110014#
product: MODEL1310110014#
kinetic law: MODEL1310110014#

metaR GALASE6ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
product: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
reversible: false
is: SBO:0000176

metaM cmpacna c
boundary condition: false
is: CHEBI:57812
type: Species
name: CMP-N-acetyl-beta-neuraminate(2-)
is: HMDB01176
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false

metaR r0321
is: SBO:0000176
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/6.3.5.2
product: MODEL1310110014#
reversible: false
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16

metaM anth e
initial concentration: 1.0
name: anthranilate
constant: false
type: Species
has only substance units: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
is: CHEBI:16567
boundary condition: false
is: HMDB01123
is: SBO:0000247
initial amount: NaN

metaM fadh2 x
type: Species
initial concentration: 1.0
is: HMDB01197
name: FADH2(2-)
is: CHEBI:58307
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
constant: false
has only substance units: false
initial amount: NaN

metaM HC01403 m
is: CHEBI:28325
name: (S)-Hydroxydecanoyl-CoA
type: Species
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR ADRNCRNt
kinetic law: MODEL1310110014#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) or (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
product: MODEL1310110014#
name: transport into the mitochondria (carnitine)

metaR ADK3
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
is: SBO:0000176
reactant: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
is described by: ECO:0000269
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
reversible: true
name: adentylate kinase (GTP)
product: MODEL1310110014#

metaM chol n
is: HMDB00097
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
initial amount: NaN
initial concentration: 1.0
name: choline
is: SBO:0000247
is: CHEBI:15354
type: Species
boundary condition: false
has only substance units: false

metaR RE1709C
fast: false
kinetic law: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
reversible: true
type: Reaction
is: SBO:0000176
reactant: MODEL1310110014#
is described by: ECO:0000000
name: RE1709

metaR SCP21cx
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of phytanoylcoa from cytosol to peroxisomes.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_ae03dbb5_d1db_42d9_8b4f_c11bed18d337
is: SBO:0000252
is encoded by: hsa:3423
initial amount: NaN
has only substance units: false
boundary condition: true
is: P22304
type: Species
constant: false
name: IDS
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_db659b2f_5190_41ac_97a9_dac1a40c587d
is: SBO:0000252
boundary condition: true
is encoded by: hsa:LOC728997
type: Species
has only substance units: false
initial concentration: NaN
constant: false
name: _LOC728997_1_c
initial amount: NaN

metaR LTC4CP
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
name: Leukotriene C4 carboxypeptidase
is described by: ECO:0000000
reactant: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
reversible: true
type: Reaction
product: MODEL1310110014#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110014#_965793e6_aa4d_46bc_aa2a_754cae053c18
has only substance units: false
name: CHAT
initial concentration: NaN
is: D3DX95
is: SBO:0000252
type: Species
boundary condition: true
constant: false
is encoded by: hsa:1103
initial amount: NaN

metaR XOL27OHtm
fast: false
product: MODEL1310110014#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110014#
name: 27 hydroxy cholesterol transport
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_1733be26_876d_4c9e_a585_d1fff9a9885b
is encoded by: hsa:3658
boundary condition: true
initial amount: NaN
name: IREB2
is: P48200
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species

metaM tetpent6coa x
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
constant: false
has only substance units: false
type: Species
is: SBO:0000247
name: tetracosapentaenoyl coenzyme A, n-6
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: C16172

metaM ocdcea e
initial concentration: 1.0
is: C00712
boundary condition: false
is: HMDB00207
is: CHEBI:0
name: octadecenoate (n-C18:1)
type: Species
notes: FORMULA: C18H33O2 CHARGE: -1
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247

metaR FAOXC13C11m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C13-->C11)m
type: Reaction

metaR r1116
reversible: true
product: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
kinetic law: MODEL1310110014#
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
fast: false
is described by: ECO:0000000
type: Reaction

metaR ELAIDt
kinetic law: MODEL1310110014#
product: MODEL1310110014#
name: fatty acid transport via diffusion
reversible: true
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_1fe08ef3_1d20_41e5_b993_5f9b5c2cb202
constant: false
is encoded by: hsa:84720
name: PIGO
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR C120CPT1
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanoylcarnitine
type: Reaction

metaR r0779
product: MODEL1310110014#
reactant: MODEL1310110014#
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
reversible: false
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
fast: false

metaR r0016
notes: GENE_ASSOCIATION: (1356.1) or (2495.1) or (2509.1) or (94033.1) or (84343.1) SUBSYSTEM: Miscellaneous EC Number: 1.16.3.1 Confidence Level: 0 AUTHORS: PMID:16405854,PMID:2154449,PMID:9162052,PMID:9722559 NOTES:
modifier: MODEL1310110014#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
name: Fe(II):oxygen oxidoreductase Porphyrin and chlorophyll metabolism EC:1.16.3.1
fast: false
is version of: http://identifiers.org/ec-code/1.16.3.1
reversible: true
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_832ee403_71a3_451f_a079_9f4835baaa09
type: Species
boundary condition: true
has only substance units: false
name: VNN3
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:55350
constant: false

metaM adp m
is: C00008
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB01341
is: http://identifiers.org/pubchem.compound/3310
boundary condition: false
has only substance units: false
is: CHEBI:456216
is: SBO:0000247
name: ADP
constant: false

metaM but e
is: HMDB00039
type: Species
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
name: butyrate
is: CHEBI:17968

metaR CDS
reversible: false
is described by: ECO:0000000
name: phosphatidate cytidylyltransferase
type: Reaction
reactant: MODEL1310110014#
modifier: MODEL1310110014#
product: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (1040.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:ER membrane - but on cytosolic surface NJ
is version of: http://identifiers.org/ec-code/2.7.7.41
is: SBO:0000176

metaM HC02179 e
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
constant: false
initial amount: NaN
initial concentration: 1.0
name: 20-hydroxy-arachidonate
has only substance units: false
is: CHEBI:34306
is: SBO:0000247
boundary condition: false
type: Species

metaM occoa m
initial concentration: 1.0
initial amount: NaN
is: C01944
boundary condition: false
has only substance units: false
is: CHEBI:57386
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
type: Species
is: SBO:0000247
is: HMDB01070
name: Octanoyl-CoA (n-C8:0CoA)
constant: false

metaR CO2tm
fast: false
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
is: SBO:0000185
name: CO2 transport (diffusion), mitochondrial
is described by: ECO:0000000
product: MODEL1310110014#

metaR GGH 5THFe
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
modifier: MODEL1310110014#
product: MODEL1310110014#
reversible: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110014#
name: Gamma-glutamyl hydrolase (5THF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
reactant: MODEL1310110014#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_7102a9ef_532e_4746_b4a2_f3142ebf6d4c
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:622
has only substance units: false
is: Q02338
constant: false
initial amount: NaN
name: BDH1

metaM dhlam m
is: SBO:0000247
initial amount: NaN
name: dihydrolipoamide
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
initial concentration: 1.0
has only substance units: false
is: CHEBI:17694
type: Species
boundary condition: false
constant: false
is: HMDB00985

metaM C05279 m
boundary condition: false
initial concentration: 1.0
is: CHEBI:28387
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
is: SBO:0000247
constant: false
is: HMDB11123
type: Species
initial amount: NaN
name: trans,cis-Lauro-2,6-dienoyl-CoA
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_23e3526d_eb1d_4d71_afca_bb7c96d9c2d4
is encoded by: hsa:1607
constant: false
initial concentration: NaN
initial amount: NaN
is: Q9Y6T7
name: DGKB
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR CH25H
is: SBO:0000176
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110014#
is described by: ECO:0000269
type: Reaction
name: cholesterol 25-hydroxylase
modifier: MODEL1310110014#
fast: false
is version of: http://identifiers.org/ec-code/1.14.99.38
reversible: false
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_500991d4_3007_4a1e_9b3c_8b9710e2c5fa
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4860
type: Species
boundary condition: true
name: PNP
is: P00491
initial amount: NaN

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

metaR CHOLATEt3
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000269
kinetic law: MODEL1310110014#
is: SBO:0000185
name: ABC bile acid transporter
notes: GENE_ASSOCIATION: (8714.3) or (8647.1) or (8714.2) or (8714.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9738950,PMID:9806540,PMID:9813153 NOTES:for bile acid secretion into bile NJ
reversible: false
product: MODEL1310110014#
type: Reaction
fast: false

metaM ksi deg37 l
boundary condition: false
name: keratan sulfate I, degradation product 37
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16953
notes: FORMULA: C62H104N4O46 CHARGE: 0
constant: false
is: SBO:0000247
is: HMDB00812
type: Species
has only substance units: false

metaM hs deg22 l
is: CHEBI:21338
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB02704
initial amount: NaN
constant: false
notes: FORMULA: C37H56NO35S CHARGE: -3

http://identifiers.org/biomodels.db/MODEL1310110014#_79b1a42e_5aa5_4a24_8f91_4463ddd7feae
name: DGKH
constant: false
initial concentration: NaN
is: Q86XP1
initial amount: NaN
is encoded by: hsa:160851
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_cd697379_1488_4ba7_ae8b_8218bf09b88c
name: ALDH4A1
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:8659
initial concentration: NaN

metaR OCDEAFABP1tc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of octadecenoyl coA into the enterocytes
type: Reaction

metaR r0163
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873,PMID:3207422 NOTES:
reactant: MODEL1310110014#
is: SBO:0000176
reversible: true
fast: false
product: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
name: 2-oxoglutarate dehydrogenase E1 component Citrate cycle (TCA cycle) EC:1.2.4.2

metaM 3hexdcrn e
notes: FORMULA: C23H45NO5 CHARGE: 0
name: 3-hydroxyhexadecanoylcarnitine
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB13336
constant: false

metaM 6a2ohxnt x
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
initial concentration: 1.0
name: 6-amino-2-oxohexanoic acid
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB12151
is: CHEBI:17534
boundary condition: false

metaM hdd2crn c
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB06317
has only substance units: false
initial amount: NaN
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
name: trans-Hexadec-2-enoyl carnitine

metaM galside hs l
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial concentration: 1.0
is: CHEBI:12947
initial amount: NaN
has only substance units: false
name: D-galactosyl-N-acylsphingosine
type: Species

metaM docohepcoa m
constant: false
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN
type: Species
name: 2,4,7,10,13,16,19-docosaheptenoylcoa
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR DM T antigen g
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

metaM frdp r
is: SBO:0000247
is: C00448
name: Farnesyl diphosphate
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:175763
type: Species
is: HMDB00961
initial amount: NaN

metaM arg L m
initial concentration: 1.0
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
type: Species
is: SBO:0000247
is: HMDB00517
boundary condition: false
name: L-argininium(1+)
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:32682

metaM eitetcoa m
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
name: 5,8,11,14-eicosatetraenoylcoa
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892790
type: Species
initial concentration: 1.0

metaM Lcystin c
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: L-cystine
initial amount: NaN
boundary condition: false
constant: false
type: Species
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: HMDB00192
is: CHEBI:16283

metaR OCT11EFATP
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of vaccenic acid by cells
type: Reaction

metaM adrncoa m
type: Species
initial amount: NaN
name: adrenyl coenzyme A
constant: false
has only substance units: false
boundary condition: false
is: C16170
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205480
is: SBO:0000247
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1

metaM gpi sig r
type: Species
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
is: CHEBI:58190
is: HMDB00224
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: Y CHARGE: 0
constant: false
boundary condition: false

metaM ocdcea c
constant: false
notes: FORMULA: C18H33O2 CHARGE: -1
is: SBO:0000247
initial concentration: 1.0
type: Species
is: C00712
has only substance units: false
is: HMDB00207
initial amount: NaN
is: CHEBI:0
name: octadecenoate (n-C18:1)
boundary condition: false

metaR FAOXC164x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_a3959559_b6d9_4a5a_95e7_c0952211f296
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:3101
is: P52790
boundary condition: true
type: Species
name: HK3

metaR MTHFCm
is version of: http://identifiers.org/ec-code/3.5.4.9
type: Reaction
is described by: ECO:0000269
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
is: SBO:0000176
modifier: MODEL1310110014#
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/6.3.4.3
reactant: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_e76d698b_0c22_4ebe_a44d_a9b6dc27479e
constant: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4697
name: NDUFA4
is: O00483
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_4e9420c2_7d30_4584_ab32_19abe0b6a959
is: Q16822
initial amount: NaN
is encoded by: hsa:5106
initial concentration: NaN
constant: false
name: PCK2
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_1750ee01_6ba5_457d_b000_d704c128f6f7
is: Q7L2M7
type: Species
boundary condition: true
is encoded by: hsa:5211
initial amount: NaN
initial concentration: NaN
name: PFKL
constant: false
is: SBO:0000252
has only substance units: false

metaR CO2tp
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110014#
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: CO2 peroxisomal transport
type: Reaction
is described by: ECO:0000000

metaR SPHS1Ptr
product: MODEL1310110014#
name: sphingosine-1-phosphate transport
is described by: ECO:0000000
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110014#
is: SBO:0000185

metaM 3hexdtetcoa x
name: 3,7,10,13-hexadecatetraenoylcoa
is: SBO:0000247
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: HMDB02288
boundary condition: false
initial amount: NaN

metaM 3hibutcoa m
is: HMDB01052
is: CHEBI:28259
boundary condition: false
constant: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: (S)-3-Hydroxyisobutyryl-CoA
initial concentration: 1.0
type: Species

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaM 3dodtricoa x
boundary condition: false
is: C05279
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB11123
name: 3,6,9-dodecatrienoylcoa
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_d85ebbd6_ea8d_4dda_b234_b4a8d22064ac
has only substance units: false
constant: false
is encoded by: hsa:121278
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: TPH2
initial concentration: NaN
is: Q8IWU9

metaM frdp x
name: farnesyl pyrophosphate(3-)
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:175763
type: Species
is: HMDB00961
is: SBO:0000247
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
initial concentration: 1.0
boundary condition: false

metaM dcacoa c
boundary condition: false
is: C05274
is: CHEBI:61430
type: Species
initial concentration: 1.0
is: HMDB06404
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
name: Decanoyl-CoA (n-C10:0CoA)
is: SBO:0000247

metaR IZPN
fast: false
is: SBO:0000176
product: MODEL1310110014#
type: Reaction
name: Imidazolonepropionase
is described by: ECO:0000000
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110014#_ea470103_c4cc_41aa_b7c0_4f06e0cce3ac
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: _AA526438_1_c
has only substance units: false
type: Species
is encoded by: hsa:AA526438
is: SBO:0000252

metaM ksi deg29 l
name: keratan sulfate I, degradation product 29
type: Species
constant: false
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00143
is: SBO:0000247
is: CHEBI:12936
has only substance units: false

metaR FAS180COA
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110014#
fast: false
product: MODEL1310110014#
reversible: false
name: fatty-acyl-CoA synthase (n-C18:0CoA)

metaM cs a deg3 l
is: CHEBI:15748
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C31H48NO32S2 CHARGE: -3
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
constant: false
is: HMDB00127

http://identifiers.org/biomodels.db/MODEL1310110014#_7a21619a_aeb5_4576_ac39_7b34d343a0fc
initial concentration: NaN
has only substance units: false
name: PEMT
is encoded by: hsa:10400
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is: Q9UBM1

http://identifiers.org/biomodels.db/MODEL1310110014#_e9d192fd_e4b4_44e8_9ed2_136df361d316
initial amount: NaN
name: _X63359_1_c
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:X63359

metaM fru e
name: D-Fructose
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: C00095
constant: false
is: CHEBI:15824
has only substance units: false
initial amount: NaN
is: HMDB00660

metaR CYTK6n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
kinetic law: MODEL1310110014#
is described by: ECO:0000269
reactant: MODEL1310110014#
reversible: true
name: cytidylate kinase (CMP,CTP),nuclear
modifier: MODEL1310110014#
is: SBO:0000176
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_769744b0_5774_4dca_9ff2_583e35743c3e
type: Species
is encoded by: hsa:5834
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
name: PYGB
is: P11216

metaR r2079
modifier: MODEL1310110014#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
product: MODEL1310110014#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110014#
fast: false

metaR PI3P3Pn
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110014#
name: phosphatidylinositol-3-phosphate 3-phosphatase, nuclear
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:EC 3.1.3.- NCD
type: Reaction
product: MODEL1310110014#

metaR BILIRUBtr
reversible: true
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110014#
type: Reaction

metaM ksi l
constant: false
is: SBO:0000247
is: C00445
boundary condition: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: CHEBI:57455
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
name: keratan sulfate I
is: HMDB01354

metaR DRIBt
is described by: ECO:0000000
reversible: true
name: deoxyribose transport via diffusion
fast: false
type: Reaction
product: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
kinetic law: MODEL1310110014#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110014#_7a4c841e_ef0a_4811_86f3_07c2fd837453
is encoded by: hsa:954
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
name: ENTPD2
type: Species
is: Q5SPY7
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_f4071175_83e5_44fe_967f_b485912c55e6
name: COX2
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4513
is: Q7GXZ8

metaR sink tetdece1coa LPAREN c RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDECE1COASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_b01c81ca_805b_4374_bf3d_db9f184447c0
is: O60312
is encoded by: hsa:57194
is: SBO:0000252
name: ATP10A
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
constant: false

metaM 2oxoadp m
is: HMDB00225
boundary condition: false
has only substance units: false
name: 2-oxoadipate(2-)
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: CHEBI:57499
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_bed5773f_24f6_45d3_b122_d7a41e34a3b2
type: Species
has only substance units: false
is encoded by: hsa:6818
name: SULT1A3
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_c8f025a6_7f30_4f8c_8c54_18a0d5757cc2
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
name: _LOC374569_1_e
is encoded by: hsa:LOC374569
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_14dbfb53_87c9_4e4e_bb87_487fd9f3b1b1
constant: false
type: Species
is encoded by: hsa:56474
initial concentration: NaN
boundary condition: true
is: Q9NRF8
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: CTPS2

http://identifiers.org/biomodels.db/MODEL1310110014#_74b7596c_9978_41a0_b302_90de641f9ece
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: Q99714
initial concentration: NaN
name: HSD17B10
type: Species
is encoded by: hsa:3028
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_80f387ab_5281_43b3_a40e_badabfee8962
is: SBO:0000297
type: Species
has part: P23434
has only substance units: false
is encoded by: hsa:275
has part: P23378
initial amount: NaN
name: DLD:GCSH:GLDC:AMT
initial concentration: NaN
is encoded by: hsa:2731
is encoded by: hsa:2653
boundary condition: true
constant: false
has part: P48728

http://identifiers.org/biomodels.db/MODEL1310110014#_3bc1e5e2_1c26_4394_9d97_e09bc406dfdf
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q86YN1
name: DOLPP1
is encoded by: hsa:57171
initial amount: NaN
constant: false
boundary condition: true

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaM etfox m
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
name: Electron transfer flavoprotein oxidized
is: CHEBI:17263
notes: FORMULA: R CHARGE: 0
has only substance units: false
is: HMDB00145

metaR FAOXC101C102x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)x
type: Reaction

metaM leuktrD4 e
name: Leukotriene D4
is: HMDB03080
constant: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:28666
initial amount: NaN

metaR GALASE14ly
fast: false
is described by: ECO:0000000
modifier: MODEL1310110014#
reversible: false
kinetic law: MODEL1310110014#
is: SBO:0000176
name: beta-galactosidase, lysosomal
product: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR ACGPID
product: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
name: N-acetylglucosaminylphosphatidylinositol deacetylase
reactant: MODEL1310110014#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
kinetic law: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.89
reversible: false

metaR FAOXC2442246x
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
name: Beta oxidation of long chain fatty acid
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c24:4,n-6 -> c22:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR PRO1x
reactant: MODEL1310110014#
is: SBO:0000176
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.5.99.8
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Transport, extracellular EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
reversible: false
product: MODEL1310110014#
name: L-ProlineNAD+ 5-oxidoreductase
kinetic law: MODEL1310110014#
fast: false
type: Reaction
is described by: ECO:0000134

metaM fru c
constant: false
type: Species
initial amount: NaN
is: HMDB00660
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
has only substance units: false
name: D-Fructose
is: C00095
is: CHEBI:15824

metaM adp n
has only substance units: false
is: CHEBI:456216
initial concentration: 1.0
is: SBO:0000247
constant: false
name: ADP(3-)
is: HMDB01341
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_b6b01e8c_d343_483a_8b36_3a2efcaad67c
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:3425
boundary condition: true
has only substance units: false
is: SBO:0000252
name: IDUA
is: P35475
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_b112c602_a4c7_44c6_9a8e_34e32a3abd0b
is encoded by: hsa:6487
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
name: ST3GAL3
boundary condition: true
has only substance units: false
type: Species

metaM HC02204 e
boundary condition: false
is: SBO:0000247
is: CHEBI:27624
initial concentration: 1.0
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
name: prostaglandin-b1
initial amount: NaN
constant: false
has only substance units: false

metaR CORE3GTg
type: Reaction
kinetic law: MODEL1310110014#
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
is: SBO:0000176
product: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
fast: false

metaR DM anth
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaR S6T8g
reactant: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
modifier: MODEL1310110014#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110014#
reversible: false
fast: false
is described by: ECO:0000000
is: SBO:0000176

metaR O2tp
is: SBO:0000185
product: MODEL1310110014#
reversible: true
reactant: MODEL1310110014#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110014#
type: Reaction
name: O2 transport, peroxisomal

metaR FAOXC164GC163m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

metaR r1554
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110014#
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110014#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110014#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110014#_445d25ad_5fcd_4f9c_b7b7_f5b0d86880ba
is: SBO:0000252
type: Species
is encoded by: hsa:25902
initial concentration: NaN
has only substance units: false
is: B2RD24
name: MTHFD1L
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_022b54ba_270d_4adb_b3c2_007efd164fe6
name: SLC26A1
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10861
boundary condition: true
type: Species
is: Q9H2B4
initial amount: NaN

metaM HC01403 x
constant: false
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
name: (S)-Hydroxydecanoyl-CoA
is: CHEBI:28325

http://identifiers.org/biomodels.db/MODEL1310110014#_531702f5_54b0_4cc1_8a48_2050992ba79d
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:AV717590
name: _AV717590_1_m
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_e06d59f6_7711_4138_88df_10255dab676e
is encoded by: hsa:55907
is: Q8NFW8
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: CMAS
has only substance units: false
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_1695879b_df96_43fd_9960_7fc59295a144
is encoded by: hsa:9245
boundary condition: true
constant: false
name: GCNT3
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is: O95395

metaR r0885
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is version of: http://identifiers.org/ec-code/1.3.1.38
modifier: MODEL1310110014#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#
type: Reaction

metaM lnlccoa m
is: SBO:0000247
type: Species
is: HMDB01064
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5462164
has only substance units: false
initial amount: NaN
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
constant: false
name: linoleic coenzyme A

metaM leuktrD4 c
constant: false
is: SBO:0000247
name: Leukotriene D4
initial concentration: 1.0
type: Species
is: HMDB03080
initial amount: NaN
has only substance units: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: CHEBI:28666
boundary condition: false

metaR FAOXC123m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_09e51e24_bb11_4516_9d10_04e0ef1cbe46
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:56301
is: Q9NS82
boundary condition: true
name: SLC7A10
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_6d956d41_6c30_4c45_86a8_fca92669cb6a
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
name: GAPDH
is encoded by: hsa:2597
has only substance units: false
boundary condition: true
is: SBO:0000252
is: E7EUT4

http://identifiers.org/biomodels.db/MODEL1310110014#_dfeead9e_dc5d_440a_9163_6c32f238d220
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:27232
constant: false
name: GNMT
initial amount: NaN
initial concentration: NaN
type: Species
is: Q14749

metaR FUMAC
modifier: MODEL1310110014#
reversible: false
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
name: fumarylacetoacetase
is described by: ECO:0000269
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.7.1.2
product: MODEL1310110014#
is: SBO:0000176

metaM 2oxoadp c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00225
type: Species
name: 2-oxoadipate(2-)
is: CHEBI:57499
constant: false

metaM arg L e
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00517
has only substance units: false
name: L-argininium(1+)
is: CHEBI:32682
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_3ea655fe_c2f7_445d_8dc7_16c2fc05f34f
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:56848
initial amount: NaN
constant: false
is: SBO:0000252
is: Q9NRA0
name: SPHK2

metaM dgmp c
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:57673
name: dGMP
is: HMDB01044
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
initial concentration: 1.0
constant: false
is: SBO:0000247
is: C00362
boundary condition: false

metaR G14T3g
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000176
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: false

metaR S6TASE15ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110014#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110014#
reversible: true
fast: false
modifier: MODEL1310110014#
product: MODEL1310110014#

metaR r1553
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110014#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110014#
reversible: true
reactant: MODEL1310110014#

metaR FAOXC101C102m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

metaM HC02204 c
boundary condition: false
is: CHEBI:27624
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
name: prostaglandin-b1
type: Species
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_1b582c62_2293_4a39_ba5d_00a60ade7e43
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:205
type: Species
boundary condition: true
initial concentration: NaN
constant: false
name: AK4

http://identifiers.org/biomodels.db/MODEL1310110014#_d003da01_8739_4805_bf9b_a4a38a53bff8
is encoded by: hsa:51022
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q9NS18
name: GLRX2
initial concentration: NaN
boundary condition: true

metaR LGNCt
kinetic law: MODEL1310110014#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
reactant: MODEL1310110014#
reversible: true
is: SBO:0000185
product: MODEL1310110014#
is described by: ECO:0000000

metaR DOLP Lter
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: dolichol phosphate flippase (liver)
reversible: false
type: Reaction
product: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110014#

metaR RE3074X
kinetic law: MODEL1310110014#
reversible: true
fast: false
modifier: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
is: SBO:0000176
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: RE3074
notes: GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:11060359,PMID:11356164 NOTES:IT - fixed proton
type: Reaction

metaR NADtpu
is: SBO:0000185
reversible: false
name: NAD transporter, peroxisome
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
type: Reaction
product: MODEL1310110014#
is described by: ECO:0000000

metaM ksii core2 pre5 g
is: HMDB00175
constant: false
is: C00130
type: Species
is: SBO:0000247
notes: FORMULA: C61H99N5O43X CHARGE: -1
has only substance units: false
is: CHEBI:58053
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 5

http://identifiers.org/biomodels.db/MODEL1310110014#_5cc7f6b7_abee_4c40_860e_e3c770438e44
has only substance units: false
initial concentration: NaN
has part: P13807
name: GYG1:GYS1
type: Species
is encoded by: hsa:2997
is: SBO:0000297
initial amount: NaN
boundary condition: true
constant: false

metaR C81CPT1
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of ocetenoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_cc7a014b_aece_4242_b10f_db50aa80681f
initial concentration: NaN
is: E7ETH5
boundary condition: true
constant: false
is: SBO:0000252
type: Species
name: SLC13A2
initial amount: NaN
has only substance units: false
is encoded by: hsa:9058

metaM hs deg11 l
initial amount: NaN
is: SBO:0000247
name: heparan sulfate, degradation product 11
initial concentration: 1.0
type: Species
is: CHEBI:57737
has only substance units: false
is: HMDB00868
constant: false
notes: FORMULA: C55H81N3O67S7 CHARGE: -8
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_4eae5e73_725c_46d1_85a6_9549a42a26b7
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI191472
initial concentration: NaN
is: SBO:0000252
constant: false
name: _AI191472_1_c

metaR r1556
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_deee2f52_51fd_4d3d_b7fe_2eb74eac9768
is: SBO:0000252
is: Q14435
type: Species
has only substance units: false
constant: false
name: GALNT3
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2591
boundary condition: true

metaR r0774
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
fast: false
type: Reaction
modifier: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110014#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110014#_5477664e_8543_4f55_9622_0a39b0a6ec2e
type: Species
initial amount: NaN
name: SLC25A18
constant: false
is: SBO:0000252
is: Q9H1K4
boundary condition: true
initial concentration: NaN
is encoded by: hsa:83733
has only substance units: false

metaR GAMt1r
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
is: SBO:0000185
reversible: true
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
product: MODEL1310110014#
name: glucosamine transport (uniport)
reactant: MODEL1310110014#

metaR 1PPDCRp
kinetic law: MODEL1310110014#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
reversible: false
product: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
fast: false
is described by: ECO:0000000
name: delta1-piperideine-2-carboxylate reductase, perixosomal

http://identifiers.org/biomodels.db/MODEL1310110014#_26c3ea7d_1ab7_4aef_9d7c_f7b3ae6693fe
is: Q9Y6K8
initial amount: NaN
has only substance units: false
is encoded by: hsa:26289
name: AK5
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_4a13defd_ecc3_410e_bb8a_6d903ef94288
has only substance units: false
initial amount: NaN
name: LDHAL6B
is encoded by: hsa:92483
initial concentration: NaN
type: Species
is: Q9BYZ2
constant: false
boundary condition: true
is: SBO:0000252

metaR PEHSFABPe
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of lysophosphatidylethanolamine into the enterocytes
type: Reaction

metaR TSTSTERONESULT
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (6822.1) or (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES:NJ
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.14
product: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110014#
name: testosterone sulfotransferase

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaM arg L c
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00517
is: CHEBI:32682
initial concentration: 1.0
boundary condition: false
type: Species
name: L-argininium(1+)
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065

http://identifiers.org/biomodels.db/MODEL1310110014#_8ef200fd_e98f_4dbc_bd90_b0b62cc86148
name: GCNT2
constant: false
initial amount: NaN
is: Q08M29
is: SBO:0000252
is encoded by: hsa:2651
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

metaM dgmp e
boundary condition: false
is: CHEBI:57673
name: dGMP(2-)
has only substance units: false
is: HMDB01044
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species

metaM 3dodtricoa m
is: SBO:0000247
initial amount: NaN
is: HMDB11123
boundary condition: false
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
name: 3,6,9-dodecatrienoylcoa
initial concentration: 1.0
constant: false
is: C05279
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_4060102f_d5b4_43bb_bf60_07fbc8b2127c
constant: false
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4729
boundary condition: true
name: NDUFV2
is: P19404

metaM adp r
constant: false
is: HMDB01341
initial concentration: 1.0
name: ADP(3-)
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
type: Species
is: SBO:0000247
is: CHEBI:456216
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_88b3dbdd_d920_4918_9537_24d2868fa03b
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
name: UCKL1
constant: false
is: SBO:0000252
is encoded by: hsa:54963
is: Q53HM1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_metaR_EX_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIA glycolipid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_b7af4264_ac62_4a18_abaa_b373c3a4dbb7
name: MAT2B
is: SBO:0000252
is encoded by: hsa:27430
is: Q9NZL9
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: NaN
boundary condition: true

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_e5e854a2_fe3f_4f4d_8066_d80ac3dd6516
initial amount: NaN
name: DGAT2
is: Q96PD7
is: SBO:0000252
is encoded by: hsa:84649
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species

metaM 3tetd7ecoa m
type: Species
initial amount: NaN
has only substance units: false
name: 3-hydroxy tetradecenoyl-7-coa
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB05066
notes: FORMULA: C35H56N7O18P3S CHARGE: -4

metaM HC02121 c
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
name: S-(hydroxymethyl)glutathione(1-)
is: CHEBI:58758
type: Species
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
is: SBO:0000247
initial concentration: 1.0

metaR 3AIBt
fast: false
reversible: false
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:HOW? IT
name: 3-amino-isobutyrate transport
type: Reaction
is described by: ECO:0000000
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000185

metaR ADMDC
is version of: http://identifiers.org/ec-code/4.1.1.50
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (262.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.50 Confidence Level: 4 AUTHORS: PMID:2460457 NOTES:
type: Reaction
name: adenosylmethionine decarboxylase
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
product: MODEL1310110014#
fast: false
is: SBO:0000176

metaR r0165
modifier: MODEL1310110014#
name: UTP:pyruvate O2-phosphotransferase EC:2.7.1.40
fast: false
is: SBO:0000176
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
product: MODEL1310110014#
reversible: false
kinetic law: MODEL1310110014#
is described by: ECO:0000000
type: Reaction

metaR UGCG
modifier: MODEL1310110014#
is described by: ECO:0000000
type: Reaction
name: Ceramide glucosyltransferase
product: MODEL1310110014#
is: SBO:0000176
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
reversible: false
kinetic law: MODEL1310110014#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.80

metaM HC01444 e
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
name: Galactosylglycerol
has only substance units: false
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
is: SBO:0000247
is: CHEBI:15754
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_74718d87_b025_45f9_a40b_95ffc37a97e4
name: _AI620219_1_c
initial amount: NaN
is encoded by: hsa:AI620219
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false

metaM glygn1 c
is: SBO:0000247
is: CHEBI:17115
notes: FORMULA: C66H111O56X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02133
constant: false
has only substance units: false
type: Species
name: glycogen, structure 1 (glycogenin-11[1,4-Glc])
boundary condition: false
is: HMDB00187
initial amount: NaN
initial concentration: 1.0

metaR AG13T1g
kinetic law: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110014#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
product: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176

metaR ALAR
kinetic law: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110014#
is: SBO:0000176
reactant: MODEL1310110014#
reversible: true
type: Reaction
modifier: MODEL1310110014#
is described by: ECO:0000212
name: alanine racemase

http://identifiers.org/biomodels.db/MODEL1310110014#_3bb0f4c7_f141_4c1a_85d8_6c11f58fc761
is: SBO:0000252
constant: false
initial amount: NaN
is: Q7GXY9
type: Species
has only substance units: false
name: ND2
is encoded by: hsa:4536
initial concentration: NaN
boundary condition: true

metaM gd3 hs g
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
initial concentration: 1.0
constant: false
name: GD3
boundary condition: false
is: SBO:0000247
is: CHEBI:28424
initial amount: NaN
has only substance units: false
type: Species

metaR ACACT6p
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110014#
name: acetyl-CoA C-acetyltransferase (dodecanoyl), peroxisomal
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
fast: false
reactant: MODEL1310110014#
type: Reaction
modifier: MODEL1310110014#

metaR PE HSter
kinetic law: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000185
name: phosphatidylethanolamine scramblase
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
type: Reaction
product: MODEL1310110014#
reversible: true
fast: false

metaM occoa x
is: CHEBI:57386
is: SBO:0000247
type: Species
is: HMDB01070
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: C01944
boundary condition: false
constant: false
name: Octanoyl-CoA (n-C8:0CoA)
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944

metaM dgdp n
initial amount: NaN
is: HMDB00960
constant: false
is: CHEBI:58595
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: SBO:0000247
initial concentration: 1.0
name: dGDP(2-)
type: Species
boundary condition: false

metaM ksii core4 deg4 l
initial concentration: 1.0
notes: FORMULA: C66H108N6O48SX CHARGE: -1
name: keratan sulfate II (core 4-linked), degradation product 4
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB00812
is: CHEBI:16953
has only substance units: false
boundary condition: false
constant: false

metaR r1557
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#

metaM lnlccoa r
is: HMDB01064
is: SBO:0000247
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
name: linoleic coenzyme A
has only substance units: false
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/5462164
initial amount: NaN
boundary condition: false
type: Species

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaR ILEt4
name: L-isoleucine transport in via sodium symport
kinetic law: MODEL1310110014#
reversible: false
fast: false
is: SBO:0000185
modifier: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
is described by: ECO:0000304
type: Reaction
product: MODEL1310110014#

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaR RE2426C
kinetic law: MODEL1310110014#
reversible: true
type: Reaction
fast: false
name: RE2426
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:
is described by: ECO:0000000
product: MODEL1310110014#
is: SBO:0000176
reactant: MODEL1310110014#

metaR RE3005M
modifier: MODEL1310110014#
fast: false
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE3005
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reversible: true
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110014#
is described by: ECO:0000000

metaM CE2422 m
boundary condition: false
is: CHEBI:28387
is: HMDB11123
is: SBO:0000247
constant: false
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
has only substance units: false

metaM adp x
is: SBO:0000247
name: ADP(3-)
is: CHEBI:456216
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: HMDB01341
type: Species

metaR DDECCRNe
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of lauroyl carnitine into extra cellular space
type: Reaction

metaR G16MT L
is described by: ECO:0000000
product: MODEL1310110014#
name: Glycolipid 1,6-alpha-D-mannosyltransferase (liver)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110014#
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_31edc005_4362_4349_9e85_5e87d175c5e6
is encoded by: hsa:2880
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial amount: NaN
name: GPX5
is: O75715

metaR O2tn
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: O2 nuclear transport
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR MTHFD2m
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
product: MODEL1310110014#
is described by: ECO:0000254
reversible: true
is: SBO:0000176
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
modifier: MODEL1310110014#
type: Reaction
fast: false
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.5.4.9
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_590ad7df_70d8_4eec_b2d2_db8073c03d76
is: SBO:0000252
initial concentration: NaN
name: FH
boundary condition: true
has only substance units: false
is: P07954
initial amount: NaN
is encoded by: hsa:2271
constant: false
type: Species

metaM adpac x
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
name: adipic acid
is: HMDB00448
type: Species
notes: FORMULA: C6H8O4 CHARGE: -2
initial amount: NaN

metaM dgdp m
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
name: dGDP(2-)
is: CHEBI:58595
is: HMDB00960
type: Species

metaM but c
is: CHEBI:17968
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
name: butyrate
boundary condition: false
is: HMDB00039
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: SBO:0000247

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaM C05965 e
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57444
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB04243
name: 12(S)-HPETE(1-)
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965

metaR AMACR2p
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110014#
fast: false
reversible: false
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (23600.1) or (23600.2) SUBSYSTEM: Bile acid synthesis EC Number: 5.1.99.4 Confidence Level: 2 AUTHORS: NOTES:should be analogous to AMACRp as per KEGG - in this case: reductase not a racemase NJ
name: alpha-methylacyl-CoA racemase (reductase)
is version of: http://identifiers.org/ec-code/5.1.99.4
is: SBO:0000176
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#

metaM lneldc c
initial amount: NaN
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB06270
boundary condition: false
type: Species
name: linoelaidic acid (all trans C18:2)

metaR ARABR
name: arabinose reductase
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.21
reversible: false
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
product: MODEL1310110014#

metaR FAOXC227C226m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

metaM cs e deg2 l
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
type: Species
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
is: HMDB00812
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:16953
initial concentration: 1.0
initial amount: NaN

metaM CE5854 e
initial amount: NaN
is: CHEBI:27485
type: Species
boundary condition: false
is: HMDB02710
name: gama-CEHC-glucuronide
constant: false
initial concentration: 1.0
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
has only substance units: false
is: SBO:0000247

metaM dadp c
constant: false
has only substance units: false
is: HMDB01508
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
name: dADP
is: CHEBI:57667
is: SBO:0000247
initial concentration: 1.0
is: C00206

metaM phe L e
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: CHEBI:17295
type: Species
is: HMDB00159
boundary condition: false
name: L-phenylalanine
initial amount: NaN
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_b199fdc7_8e41_480f_9f40_997c4ac0cddf
is: O75752
is: SBO:0000252
constant: false
is encoded by: hsa:8706
initial concentration: NaN
initial amount: NaN
name: B3GALNT1
has only substance units: false
type: Species
boundary condition: true

metaM HC01397 x
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:27402
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
initial amount: NaN
has only substance units: false
name: (S)-3-Hydroxyhexadecanoyl-CoA

metaR O2tm
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
product: MODEL1310110014#
name: O2 transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
is: SBO:0000185

metaR r1559
kinetic law: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110014#
is described by: ECO:0000000

metaR ATPtm
is described by: ECO:0000269
product: MODEL1310110014#
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
type: Reaction
fast: false
reactant: MODEL1310110014#
reversible: false
is: SBO:0000185
name: ADP/ATP transporter, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110014#_1b78e84b_ec74_484d_9f19_88d2dfd7f804
initial amount: NaN
name: ALDH2
constant: false
is encoded by: hsa:217
boundary condition: true
has only substance units: false
is: P05091
initial concentration: NaN
type: Species
is: SBO:0000252

metaR CRNCARtp
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110014#
fast: false
is described by: ECO:0000000
name: carnitine-acetylcarnitine carrier, peroxisomal
product: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
reversible: false

metaM retinal 11 cis c
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: CHEBI:16066
is: HMDB02152
initial concentration: 1.0
constant: false
is: SBO:0000247
name: 11-cis-retinal
boundary condition: false

metaM btcoa c
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
is: HMDB01088
name: Butanoyl-CoA
is: C00136
constant: false
is: CHEBI:57371
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136

metaR PAN4PPe
product: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
is: SBO:0000176
name: PAN4PPe
reactant: MODEL1310110014#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134

metaR FAOXC14C12m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)m
type: Reaction

metaR GCC2cm
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
type: Reaction
name: glycine-cleavage complex (lipoamide), mitochondrial
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/2.1.2.10
fast: false
modifier: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/1.8.1.4
product: MODEL1310110014#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110014#_16b1267d_d5c7_420b_882a_dcdbfa7864fa
has only substance units: false
type: Species
is encoded by: hsa:2879
name: GPX4
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is: P36969
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_5cf12743_e3ba_4d70_a5c3_f32d08bb7c22
initial concentration: NaN
name: TKT
has only substance units: false
is encoded by: hsa:7086
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
is: E7EPA7

metaM hs deg21 l
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
notes: FORMULA: C37H55NO38S2 CHARGE: -4
type: Species
is: CHEBI:16126
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false

metaR GASNASE3ly
name: glycosylasparaginase, lysosomal
is version of: http://identifiers.org/ec-code/3.5.1.26
fast: false
type: Reaction
modifier: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
reactant: MODEL1310110014#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110014#
is described by: ECO:0000000

metaM leuleu e
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/94244
is: SBO:0000247
notes: FORMULA: C12H24N2O3 CHARGE: 0
name: Leucylleucine
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_aa85a04f_5bdd_479e_889e_dc5cae18ffbe
type: Species
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
name: ST6GAL1
is encoded by: hsa:6480
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_fb5107d2_f4b4_4fa9_861c_b0cd0ca3ff10
initial amount: NaN
constant: false
is: SBO:0000252
name: LDHB
has only substance units: false
is encoded by: hsa:3945
boundary condition: true
is: P07195
type: Species
initial concentration: NaN

metaR r2328
reactant: MODEL1310110014#
fast: false
product: MODEL1310110014#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110014#
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM 3otdcoa x
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
is: SBO:0000247
is: HMDB03935
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:28726
constant: false
boundary condition: false
name: 3-Oxotetradecanoyl-CoA
type: Species

metaM gluside hs r
name: D-glucosyl-N-acylsphingosine
initial concentration: 1.0
has only substance units: false
is: CHEBI:18368
type: Species
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_f5cedf18_5723_4696_b568_2cd48b86d37b
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: NDUFA12
is encoded by: hsa:55967
is: F8VQS7

metaM btamp c
initial concentration: 1.0
constant: false
type: Species
is: HMDB04220
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
name: Biotinyl-5'-AMP
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:3110
has only substance units: false

metaR GLYt7 211 r
product: MODEL1310110014#
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000185
fast: false
name: glycine reversible transport via sodium and chloride symport (2:1:1)
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110014#_4e9b51c1_2897_4719_b7c7_462898c11371
has only substance units: false
name: NDUFB2
initial concentration: NaN
is encoded by: hsa:4708
type: Species
is: SBO:0000252
is: H7C5B8
initial amount: NaN
constant: false
boundary condition: true

metaM adpcoa c
has only substance units: false
initial concentration: 1.0
is: C14143
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
name: adipoylcoa
is: SBO:0000247
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: HMDB04047

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_f63a1a9b_d82d_4be6_968e_8e762cacec87
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5332
type: Species
boundary condition: true
is: E2QRH8
initial concentration: NaN
name: PLCB4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_c45781de_637e_450b_b6ae_ef9d3c5d1f1e
has only substance units: false
is: SBO:0000252
name: PRDX2
is: P32119
constant: false
initial amount: NaN
is encoded by: hsa:7001
type: Species
initial concentration: NaN
boundary condition: true

metaM cs e deg4 l
is: HMDB00127
is: CHEBI:15748
has only substance units: false
notes: FORMULA: C31H46NO38S4 CHARGE: -5
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4

metaR EX c5dc
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glutaryl carnitine
type: Reaction

metaM ser L e
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: CHEBI:17115
initial concentration: 1.0
boundary condition: false
type: Species
name: L-serine
is: SBO:0000247
is: HMDB00187
initial amount: NaN
constant: false
has only substance units: false

metaR LINOFATPtc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_61f28991_b816_4bf5_b499_4ab992ac4ffb
initial concentration: NaN
is encoded by: hsa:27068
is: SBO:0000252
name: PPA2
initial amount: NaN
has only substance units: false
is: F8WDN9
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_1f0ff86d_60c6_467f_85ad_6fde211422e8
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:1373
has only substance units: false
is: SBO:0000252
is: B7ZAW0
initial amount: NaN
name: CPS1
boundary condition: true

metaR SLDt
name: L-sulfolactate transport (cytosol to extracellular)
reversible: false
reactant: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15758220 NOTES:MM
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_45123815_9004_4105_8283_1ce20d1d4e50
is encoded by: hsa:3795
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: KHK
type: Species
constant: false
initial amount: NaN
is: Q6IBK2

metaR r2327
product: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110014#
type: Reaction
fast: false

metaM acgam1p c
has only substance units: false
is: HMDB01367
constant: false
boundary condition: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:7125
name: N-Acetyl-D-glucosamine 1-phosphate

metaM homoval m
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
name: Homovanillate
initial concentration: 1.0
boundary condition: false
is: CHEBI:545959
is: HMDB00118
type: Species
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN

metaR DASCBR
name: dehydroascorbate reductase
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
modifier: MODEL1310110014#
type: Reaction
reversible: false
product: MODEL1310110014#
is described by: ECO:0000269
fast: false
is: SBO:0000176
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.8.4.1
kinetic law: MODEL1310110014#

metaM CE5786 e
initial amount: NaN
name: kinetensin
is: CHEBI:27485
type: Species
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
is: HMDB02710
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR LALDO
type: Reaction
reversible: true
fast: false
product: MODEL1310110014#
is: SBO:0000176
kinetic law: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.1.1.1

metaM leuleu c
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
name: Leucylleucine
notes: FORMULA: C12H24N2O3 CHARGE: 0
is: http://identifiers.org/pubchem.compound/94244
initial amount: NaN
initial concentration: 1.0

metaR RETt
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: Retinol transport via faciliated diffusion
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110014#_11560c1a_08f5_4849_b4e4_2b72057c4fbd
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
name: ANPEP
initial amount: NaN
is encoded by: hsa:290
is: Q59E93

metaR r0994
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
name: Facilitated diffusion
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
reversible: true
is: SBO:0000185
fast: false

metaM 10fthf6glu e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
is: HMDB00972
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:57454
name: 10-formyltetrahydrofolate-[Glu](6)
is: SBO:0000247

metaM 3docopencoa x
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
name: 3,7,10,13,16-docosapentenoylcoa
type: Species
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
is: SBO:0000247

metaR r0641
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.4
reversible: true
modifier: MODEL1310110014#
fast: false
product: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2

metaM leuktrB4 e
is: HMDB01085
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: SBO:0000247
is: CHEBI:57461
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
name: leukotriene B4(1-)

metaM sph1p e
boundary condition: false
has only substance units: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
is: HMDB01383
is: CHEBI:57939
constant: false
initial concentration: 1.0
type: Species
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: SBO:0000247
initial amount: NaN

metaR S6TASE22ly
name: galactose-6-sulfate sulfatase, lysosomal
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110014#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaM guln r
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
is: HMDB03290
is: CHEBI:13115
boundary condition: false
name: L-gulonate
type: Species

metaM ksii core2 deg1 l
has only substance units: false
is: CHEBI:57737
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
is: SBO:0000247
boundary condition: false
is: HMDB00868
name: keratan sulfate II (core 2-linked), degradation product 1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_8cf3a871_9c2f_47f4_8842_0eab434635c5
is: SBO:0000252
type: Species
boundary condition: true
name: SLC35D2
initial concentration: NaN
is: Q76EJ3
initial amount: NaN
is encoded by: hsa:11046
has only substance units: false
constant: false

metaR FAS120COA
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD
reversible: false
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
fast: false
reactant: MODEL1310110014#
is described by: ECO:0000269
kinetic law: MODEL1310110014#
is: SBO:0000176
product: MODEL1310110014#
name: fatty-acyl-CoA synthase (n-C12:0CoA)

metaR HAS2
name: hyaluronan synthase
is version of: http://identifiers.org/ec-code/2.4.1.212
product: MODEL1310110014#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
modifier: MODEL1310110014#
reversible: false
type: Reaction
reactant: MODEL1310110014#

metaM ser L c
name: L-serine
initial concentration: 1.0
is: CHEBI:17115
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB00187
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068

metaR r2329
product: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM pan4p m
name: pantetheine 4'-phosphate(2-)
boundary condition: false
is: HMDB01416
type: Species
is: SBO:0000247
is: CHEBI:47942
initial amount: NaN
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial concentration: 1.0
constant: false
has only substance units: false

metaR AKGtp
fast: false
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110014#
is described by: ECO:0000000
name: AKG transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
product: MODEL1310110014#
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_72b08cb1_af85_47c7_95f7_20cb85d397f8
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:1798
boundary condition: true
is: SBO:0000252
name: DPAGT1
type: Species
initial concentration: NaN

metaM CE5236 c
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
boundary condition: false
is: CHEBI:28002
initial amount: NaN
name: O2'-4a-cyclic-tetrahydrobiopterin
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB03952
type: Species
is: SBO:0000247

metaR RNMK
fast: false
is described by: ECO:0000269
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.1.22
modifier: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
is: SBO:0000176
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (54981.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.1.22 Confidence Level: 4 AUTHORS: PMID:15137942 NOTES:
name: ribosylnicotinamide kinase
reversible: false

metaR FAOXC12C12OHm
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->OHC12)m
type: Reaction

metaR PIter
fast: false
modifier: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: phosphate transport, endoplasmic reticulum
is: SBO:0000185
is described by: ECO:0000212
type: Reaction
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
reversible: true
product: MODEL1310110014#

metaR r1167
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110014#
name: EC:2.3.1.26
type: Reaction
is: SBO:0000176
product: MODEL1310110014#
kinetic law: MODEL1310110014#

metaR DMGtm
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
kinetic law: MODEL1310110014#
name: dimethylglycine transport via diffusion (cytosol to mitochondria)
is: SBO:0000185
product: MODEL1310110014#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110014#

metaR AMACRp
name: alpha-methylacyl-CoA racemase
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000176
product: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (23600.2) or (23600.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.1.99.4 Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid biosynthesis review uniprot NJ
is version of: http://identifiers.org/ec-code/5.1.99.4
type: Reaction
reversible: false
is described by: ECO:0000269
fast: false

metaM 3mgcoa m
is: SBO:0000247
is: HMDB01057
initial amount: NaN
is: CHEBI:57346
boundary condition: false
has only substance units: false
name: trans-3-methylglutaconyl-CoA(5-)
type: Species
initial concentration: 1.0
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
constant: false

metaM HC01410 m
has only substance units: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
is: SBO:0000247
name: (2E)-Hexenoyl-CoA
constant: false
is: CHEBI:28706
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_dbad1daf_853a_406f_be3c_b10a3b04c089
type: Species
is encoded by: hsa:427
initial amount: NaN
initial concentration: NaN
name: ASAH1
is: Q13510
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252

metaM ppbng c
notes: FORMULA: C10H13N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00588 EHMN_ABBREVIATION: C00931
boundary condition: false
is: C00931
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:58126
constant: false
initial concentration: 1.0
is: HMDB00245
is: SBO:0000247
name: Porphobilinogen

metaM CE5132 c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
initial amount: NaN
boundary condition: false
is: CHEBI:57923
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
constant: false
type: Species

metaR r0999
type: Reaction
kinetic law: MODEL1310110014#
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110014#
is: SBO:0000185
reactant: MODEL1310110014#
fast: false
is described by: ECO:0000000
reversible: true

metaR S6T13g
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110014#
reversible: false
reactant: MODEL1310110014#
fast: false
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
product: MODEL1310110014#

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_2369a715_86ae_4b24_8ec4_2730a8d57d78
is encoded by: hsa:4717
boundary condition: true
name: NDUFC1
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is: O43677
is: SBO:0000252

metaM 13 cis retn c
is: HMDB06219
initial amount: NaN
initial concentration: 1.0
name: 13-cis-retinoate
is: SBO:0000247
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/7847414
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
boundary condition: false
constant: false
is: D00348

metaR GLYKm
modifier: MODEL1310110014#
name: glycerol kinase
product: MODEL1310110014#
is described by: ECO:0000254
fast: false
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (2710.2) or (2712.1) or (2710.1) or (2713.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.30 Confidence Level: 2 AUTHORS: PMID:7987308 NOTES:TV
is version of: http://identifiers.org/ec-code/2.7.1.30
type: Reaction
reactant: MODEL1310110014#

metaR r1168
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
product: MODEL1310110014#
name: EC:2.3.1.26
reversible: false
type: Reaction
kinetic law: MODEL1310110014#
is: SBO:0000176
reactant: MODEL1310110014#

metaM sph1p c
initial amount: NaN
initial concentration: 1.0
is: HMDB01383
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
constant: false
is: CHEBI:57939
boundary condition: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_4f731567_cdb5_493e_89d4_391f743f369b
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: GALNT9
is: Q9HCQ5
is encoded by: hsa:50614

http://identifiers.org/biomodels.db/MODEL1310110014#_20bb0c4b_8f2a_47c4_9ec3_512ad62fea7b
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:1557
constant: false
is: P33261
initial concentration: NaN
name: CYP2C19

metaR SGALSIDEtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reactant: MODEL1310110014#
product: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
name: sgalside hs intracellular transport
reversible: true
fast: false
is: SBO:0000185

metaR FAOXC81C61x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)x
type: Reaction

metaR SCP2x
type: Reaction
name: peroxisomal thiolase 2
is version of: http://identifiers.org/ec-code/2.3.1.176
is: SBO:0000176
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
modifier: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways version 2 analog added as per KEGG NJ
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_1c0550dd_95b5_4ce3_b88d_6a5741da8025
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P51648
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:224
constant: false
name: ALDH3A2

metaR PAFHe
reversible: false
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.1.47
type: Reaction
kinetic law: MODEL1310110014#
is described by: ECO:0000269
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (7941.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:8675689 NOTES:NJ
name: Platelet-activating factor acetylhydrolase
fast: false
is: SBO:0000176

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaM dpcoa l
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: HMDB01373
initial amount: NaN
name: 3'-dephospho-CoA(2-)
is: CHEBI:57328
constant: false
is: SBO:0000247
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882

metaM galgalthcrm hs g
is: CHEBI:26174
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
constant: false
name: Gal-Gal-Gal-Gal-Glc-Cer
notes: FORMULA: C48H86NO27FULLRCO CHARGE: 0
initial concentration: 1.0
initial amount: NaN

metaR r0998
reversible: true
product: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: Facilitated diffusion
is described by: ECO:0000000

metaM bildglcur r
initial concentration: 1.0
name: bis(beta-glucosyluronate)bilirubin
is: CHEBI:58471
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB03325

metaR FAOXC183806m
fast: false
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
product: MODEL1310110014#
is: SBO:0000176
reversible: false
name: Beta oxidation of fatty acid

metaM ksii core2 pre4 g
name: keratan sulfate II biosynthesis, precursor 4
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C53H86N4O38X CHARGE: -1
boundary condition: false
is: C00130
constant: false
is: CHEBI:58053
is: HMDB00175

metaM ksii core2 pre10 g
initial concentration: 1.0
is: CHEBI:28067
has only substance units: false
constant: false
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
boundary condition: false
initial amount: NaN
type: Species
name: keratan sulfate II biosynthesis, precursor 10
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_0792ad7e_07c7_46e3_bff7_9dac340131c7
has only substance units: false
type: Species
is: P05187
name: ALPP
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:250

http://identifiers.org/biomodels.db/MODEL1310110014#_32a4f757_4ed7_49e7_a05e_b0d94532c073
initial concentration: NaN
type: Species
is: Q15392
is: SBO:0000252
name: DHCR24
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:1718

metaM dpcoa m
is: SBO:0000247
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
boundary condition: false
type: Species
name: 3'-dephospho-CoA(2-)
is: HMDB01373
initial amount: NaN
has only substance units: false
is: CHEBI:57328
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_9523bb96_96df_48ff_8428_5594605ee02b
initial amount: NaN
is encoded by: hsa:1109
initial concentration: NaN
boundary condition: true
is: P17516
type: Species
is: SBO:0000252
constant: false
has only substance units: false
name: AKR1C4

http://identifiers.org/biomodels.db/MODEL1310110014#_cbbc3b88_1f95_4fd3_9508_7a3848a32dd1
name: PIP5K1C
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:23396
is: O60331
is: SBO:0000252

metaR C4x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of butyrylcoa to butyrylcarnitine for transport
type: Reaction

metaR LNLCCRNt
kinetic law: MODEL1310110014#
type: Reaction
is: SBO:0000185
name: transport into the mitochondria (carnitine)
reversible: false
modifier: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_531e2ef5_9dd2_44da_ba64_6f2f49e536f2
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is: O00483
initial concentration: NaN
is encoded by: hsa:4697
constant: false
name: NDUFA4

metaM cs e deg6 l
boundary condition: false
notes: FORMULA: C31H48NO32S2 CHARGE: -3
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00812
is: CHEBI:16953
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6
constant: false
has only substance units: false

metaR RE2814R
is described by: ECO:0000000
reversible: true
name: RE2814
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
reactant: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000176
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_9f10a8a1_4d7d_40e6_a23d_f5bd8830b620
is encoded by: hsa:34
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is: P11310
name: ACADM
initial concentration: NaN
constant: false
type: Species

metaR 2HBO
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
type: Reaction
reversible: true
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
is described by: ECO:0000269
fast: false
is: SBO:0000176
modifier: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.1.1.27

metaM CE5132 n
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
has only substance units: false
initial amount: NaN
is: CHEBI:57923

metaR EICOSTETt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110014#
fast: false
product: MODEL1310110014#
is: SBO:0000185
kinetic law: MODEL1310110014#
reversible: true
name: fatty acid transport via diffusion
type: Reaction
is described by: ECO:0000000

metaR KHK2
reactant: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.3
kinetic law: MODEL1310110014#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.3 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
reversible: false
name: ketohexokinase (D-xylulose)
modifier: MODEL1310110014#
fast: false
product: MODEL1310110014#
is: SBO:0000176

metaM malttr e
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: C01835
initial amount: NaN
constant: false
is: CHEBI:27931
is: HMDB01262
name: maltotriose
has only substance units: false
type: Species
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835

metaM eipencoa x
boundary condition: false
name: 2,5,8,11,14-eicosapentaenoylcoa
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C41H60N7O17P3S CHARGE: -4

metaR r0647
type: Reaction
fast: false
kinetic law: MODEL1310110014#
product: MODEL1310110014#
name: Spontaneous reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110014#
reversible: true

metaR ALASm
product: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/2.3.1.37
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.29
name: 5-aminolevulinate synthase
type: Reaction
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_5cc89986_22f6_4605_b06d_029ccdeae381
is: SBO:0000252
name: ATG9B
is encoded by: hsa:285973
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: Q674R7

metaR FAOXC102C81m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_32e6c1a2_104e_411b_86d3_7c8fa5210d37
type: Species
constant: false
name: PANK3
is encoded by: hsa:79646
boundary condition: true
is: SBO:0000252
is: Q9H999
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM c81crn c
initial concentration: 1.0
notes: FORMULA: C15H27NO4 CHARGE: 0
constant: false
boundary condition: false
is: HMDB13324
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
name: octenoyl carnitine

metaR FAOXC18280m
name: Beta oxidation of fatty acid
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:2, transe -> c8:0 - 5 rounds of beta ox, lose 2 degrees of unsat - only 3 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000000
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000176
fast: false
reversible: false

metaM gtp c
is: C00044
name: GTP
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: HMDB01273
boundary condition: false
type: Species
is: CHEBI:37565
constant: false
initial concentration: 1.0
initial amount: NaN

metaM ser L m
name: L-serine
is: HMDB00187
initial amount: NaN
is: CHEBI:17115
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaM thcholstoic x
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:18402
constant: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
initial amount: NaN
is: HMDB03873
type: Species
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722

metaM xol7ah2 c
constant: false
type: Species
is: SBO:0000247
is: HMDB06893
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
boundary condition: false
initial amount: NaN
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha-diol
is: CHEBI:28047
initial concentration: 1.0

metaR THCHOLSTOICtm
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
product: MODEL1310110014#
type: Reaction
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_253e174f_e4e0_4710_88ba_abce8dbd13ff
initial concentration: NaN
is encoded by: hsa:128869
name: PIGU
constant: false
is: Q9H490
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true

metaM HC01104 e
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
has only substance units: false
is: SBO:0000247
is: CHEBI:61146
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
name: 4-nitrophenyl phosphate(2-)
boundary condition: false

metaM ala D x
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15570
is: SBO:0000247
type: Species
is: HMDB01310
has only substance units: false
boundary condition: false
constant: false
name: D-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1

metaM 4mop m
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00695
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
is: CHEBI:17865
is: SBO:0000247
boundary condition: false
name: 4-methyl-2-oxopentanoate
constant: false

metaM hom L e
constant: false
type: Species
initial concentration: 1.0
is: HMDB00719
name: L-homoserine
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:15699
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial amount: NaN

metaR r0842
kinetic law: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
name: Postulated transport reaction
fast: false
type: Reaction
product: MODEL1310110014#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.3.1.72
is described by: ECO:0000000
modifier: MODEL1310110014#
reactant: MODEL1310110014#

metaR r0841
fast: false
is: SBO:0000185
product: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.271
reversible: true
name: Free diffusion
modifier: MODEL1310110014#

metaM bildglcur e
has only substance units: false
initial amount: NaN
is: HMDB03325
is: CHEBI:58471
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
boundary condition: false
name: bis(beta-glucosyluronate)bilirubin
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_6cc46e0e_45a3_4379_834d_b89730cfbc58
has only substance units: false
is encoded by: hsa:5305
initial concentration: NaN
name: PIP4K2A
is: P48426
boundary condition: true
type: Species
initial amount: NaN
constant: false
is: SBO:0000252

metaM cs a deg1 l
initial concentration: 1.0
is: SBO:0000247
constant: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:16953
is: HMDB00812

metaM trdox c
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
is: CHEBI:18191
name: Oxidized thioredoxin
is: SBO:0000247
is: C00343
type: Species

metaM chito2pdol L c
has only substance units: false
constant: false
is: CHEBI:12427
initial concentration: 1.0
is: HMDB01196
type: Species
is: SBO:0000247
notes: FORMULA: C1240H2028N20O170P20 CHARGE: -20 INCHI: InChI=1S/C41H72N2O17P2/c1-25(2)13-9-14-26(3)15-10-16-27(4)17-11-18-28(5)19-12-20-29(6)21-22-55-61(51,52)60-62(53,54)59-41-35(43-31(8)47)38(50)39(33(24-45)57-41)58-40-34(42-30(7)46)37(49)36(48)32(23-44)56-40/h13,15,17,19,29,32-41,44-45,48-50H,9-12,14,16,18,20-24H2,1-8H3,(H,42,46)(H,43,47)(H,51,52)(H,53,54)/b26-15+,27-17+,28-19-/t29?,32-,33-,34-,35-,36-,37-,38-,39-,40+,41-/m1/s1
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
boundary condition: false

metaR HTDCRNe
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-tetradecanoyl carnitine into extra cellular space
type: Reaction

metaM c81crn e
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
name: octenoyl carnitine
is: HMDB13324
notes: FORMULA: C15H27NO4 CHARGE: 0
is: SBO:0000247
boundary condition: false

metaR r0840
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: Free diffusion
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.14.13.70
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_8c520cf6_9252_4db5_a2a7_457c22169e51
is: Q96RV2
boundary condition: true
type: Species
has only substance units: false
name: HAS3
is encoded by: hsa:3038
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252

metaR GLCNACASE5ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reversible: false
fast: false
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.50
modifier: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
name: alpha-N-acetylglucosaminidase, lysosomal
is: SBO:0000176

metaR ORPT
name: orotate phosphoribosyltransferase
is described by: ECO:0000269
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000176
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
kinetic law: MODEL1310110014#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.10
product: MODEL1310110014#
type: Reaction

metaR HISSNAT5tc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM gtp e
constant: false
type: Species
boundary condition: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: SBO:0000247
is: CHEBI:37565
name: GTP(4-)
initial amount: NaN
has only substance units: false
is: HMDB01273
initial concentration: 1.0

metaM 2docopencoa m
name: 2,7,10,13,16-docosapentenoylcoa
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

metaR DRBK
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000176
name: Deoxyribokinase
is described by: ECO:0000304
reversible: false
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.15 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.15
type: Reaction
reactant: MODEL1310110014#
fast: false

metaM btamp m
name: Biotinyl-5'-AMP
initial concentration: 1.0
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
initial amount: NaN
is: CHEBI:3110
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB04220
type: Species

metaR PEPCKm
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/4.1.1.32
kinetic law: MODEL1310110014#
product: MODEL1310110014#
name: Phosphoenolpyruvate carboxykinase (GTP)
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
reversible: false
type: Reaction
modifier: MODEL1310110014#
is described by: ECO:0000000
fast: false
is: SBO:0000176

metaR DOLPMT3 Uer
is version of: http://identifiers.org/ec-code/2.4.1.260
is: SBO:0000176
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110014#
fast: false
reactant: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
is described by: ECO:0000000
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
reversible: false
kinetic law: MODEL1310110014#

metaM CE5236 n
has only substance units: false
boundary condition: false
name: O2'-4a-cyclic-tetrahydrobiopterin
is: HMDB03952
is: CHEBI:28002
initial concentration: 1.0
constant: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: SBO:0000247
type: Species
initial amount: NaN

metaR FAOXC81C61m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_b6620aca_1246_40fe_8e12_d09e9be43dc9
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:57127
name: RHBG
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
is: Q9H310

metaM hom L c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: L-homoserine
boundary condition: false
type: Species
constant: false
has only substance units: false
is: CHEBI:15699
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: HMDB00719

metaR G14T20g
reversible: false
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
reactant: MODEL1310110014#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110014#

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

metaR 34HPPOR
product: MODEL1310110014#
is: SBO:0000176
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
reversible: false
fast: false
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
reactant: MODEL1310110014#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.13.11.27
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:

metaM sucr e
is: C00089
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Sucrose
has only substance units: false
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00091 EHMN_ABBREVIATION: C00089
type: Species
is: CHEBI:17992
is: HMDB00258

metaM ksi deg12 l
constant: false
type: Species
is: CHEBI:12936
is: SBO:0000247
boundary condition: false
name: keratan sulfate I, degradation product 12
initial concentration: 1.0
has only substance units: false
is: HMDB00143
initial amount: NaN
notes: FORMULA: C174H279N12O153S9 CHARGE: -9

http://identifiers.org/biomodels.db/MODEL1310110014#_f4a6a402_39a6_4534_ae63_c478c1f99231
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:51477
name: ISYNA1
is: B3KRT1
constant: false
is: SBO:0000252

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR r0643
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
product: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000

metaR H5MTer U
modifier: MODEL1310110014#
reversible: false
product: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
fast: false
name: H5 mannosyltransferase, endoplasmic reticulum
reactant: MODEL1310110014#

metaR RE2814M
type: Reaction
reversible: true
name: RE2814
product: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000000

metaR OMEPRAZOLEte
reactant: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
fast: false
reversible: true
name: xenobiotic transport
is: SBO:0000185
product: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ

http://identifiers.org/biomodels.db/MODEL1310110014#_7f39ef42_f350_4ad2_bf2d_a920cd67ca21
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species
is: P05177
name: CYP1A2
has only substance units: false
is encoded by: hsa:1544
initial amount: NaN

metaM CE4790 m
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:57923

metaR GALT
name: galactose-1-phosphate uridylyltransferase
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000176
modifier: MODEL1310110014#
fast: false
type: Reaction
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.7.12
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_7e47566a_890e_417c_a2ca_dcf90438b524
name: CA7
is: Q86YU0
initial concentration: NaN
has only substance units: false
is encoded by: hsa:766
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_7ef097b8_ab1a_4fe1_a60b_76519e092ab9
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:92483
is: Q9BYZ2
type: Species
name: LDHAL6B
constant: false
has only substance units: false
initial concentration: NaN

metaR r0642
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110014#
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
type: Reaction
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true

metaR RE0944E
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1
reversible: true
kinetic law: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.17
fast: false
type: Reaction
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
name: RE0944
modifier: MODEL1310110014#

metaM 3ivcoa c
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
initial concentration: 1.0
name: 3-hydroxyisovalerylcoa
type: Species
is: http://identifiers.org/pubchem.compound/11966188
is: SBO:0000247
has only substance units: false
is: HMDB06870
constant: false
is: C05998
initial amount: NaN
boundary condition: false

metaM dmpp x
is: SBO:0000247
initial amount: NaN
is: HMDB01120
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
constant: false
type: Species
is: CHEBI:57623
name: prenyl diphosphate(3-)
boundary condition: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_7e976384_bd79_4132_9dac_98781823cd9d
is: Q546H9
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:7915
name: ALDH5A1
constant: false
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_5aeb082e_d882_4a42_8e6d_d09236987977
has only substance units: false
constant: false
is: SBO:0000252
is: A4D1D5
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5244
boundary condition: true
name: ABCB4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_59636598_487c_4188_a33e_66afe8467fa0
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: A0PJJ9
name: GGT7
is encoded by: hsa:2686
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_d546bf2a_ae2a_4358_848e_b7b55b23d96d
is encoded by: hsa:7389
type: Species
name: UROD
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is: P06132

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaR GLCNACASE3ly
type: Reaction
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
reversible: false
is: SBO:0000176
product: MODEL1310110014#
name: alpha-N-acetylglucosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.50
fast: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110014#

metaR SLDx
product: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: true
is: SBO:0000176
fast: false
type: Reaction
name: L-sulfolactate dehydrogenase (NAD+)
reactant: MODEL1310110014#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.1.1.37
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (4190.1) or (130752.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.272 Confidence Level: 2 AUTHORS: PMID:15758220,PMID:3346220 NOTES:AMF EC: 1.1.1.272

metaR URIK1
product: MODEL1310110014#
is described by: ECO:0000269
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.1.48
name: uridine kinase (ATP:Uridine)
type: Reaction
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
kinetic law: MODEL1310110014#
is: SBO:0000176
fast: false
reversible: false

metaR NADS2
kinetic law: MODEL1310110014#
name: NAD synthase (glutamine-hydrolysing)
type: Reaction
modifier: MODEL1310110014#
is described by: ECO:0000269
product: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is version of: http://identifiers.org/ec-code/6.3.5.1
reversible: false
is: SBO:0000176

metaR GLYBt4 2 r
modifier: MODEL1310110014#
type: Reaction
reversible: true
fast: false
name: Betaine transport (sodium symport) (2:1)
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (6539.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110014#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_e45f1745_3cd6_4a20_a2a1_78ae29962a64
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: Q9NYR8
type: Species
is encoded by: hsa:50700
name: RDH8
is: SBO:0000252
initial amount: NaN

metaR GLCNACT L
product: MODEL1310110014#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (liver)
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_18621cd8_4bc5_4496_8fef_9df3d5b22b21
boundary condition: true
name: CA12
has only substance units: false
is: O43570
is encoded by: hsa:771
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false

metaM ethamp c
type: Species
name: ethamp[c]
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:58190
is: HMDB00224

metaR r0645
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
product: MODEL1310110014#
name: 2-Aminomuconate semialdehyde:NAD+ 6-oxidoreductase Tryptophan metabolism EC:1.2.1.32
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.1.32 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000000
reversible: true
type: Reaction

metaR SGALSIDEtg
kinetic law: MODEL1310110014#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110014#
reversible: true
product: MODEL1310110014#
fast: false
is: SBO:0000185
name: sgalside hs intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ

http://identifiers.org/biomodels.db/MODEL1310110014#_4bd1bf75_7358_4e4a_b6fc_bf1724a16b25
is encoded by: hsa:11226
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
type: Species
name: GALNT6
is: Q8NCL4

http://identifiers.org/biomodels.db/MODEL1310110014#_b298bc90_c27d_4055_bac1_86615ddd4e33
initial concentration: NaN
initial amount: NaN
name: CHST2
boundary condition: true
is: Q9Y4C5
type: Species
constant: false
is encoded by: hsa:9435
is: SBO:0000252
has only substance units: false

metaR KHK3
kinetic law: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.3
fast: false
reactant: MODEL1310110014#
modifier: MODEL1310110014#
name: ketohexokinase (D-tagatose)
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.3 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
reversible: false
is described by: ECO:0000269
is: SBO:0000176

metaM pmtcoa c
is: C00154
initial concentration: 1.0
name: Palmitoyl-CoA (n-C16:0CoA)
is: SBO:0000247
has only substance units: false
is: CHEBI:3454
is: HMDB01338
constant: false
type: Species
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false

metaR SUBEACTD
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberic acid into cytosol (diffusion)
type: Reaction

metaR TMDPK
product: MODEL1310110014#
fast: false
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
reactant: MODEL1310110014#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.6.2

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaR EX 3ivcrn
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-isovaleryl carnitine
type: Reaction

metaM dpcoa e
has only substance units: false
name: Dephospho-CoA
constant: false
is: CHEBI:57328
initial concentration: 1.0
is: C00882
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
type: Species
is: SBO:0000247
is: HMDB01373
initial amount: NaN
boundary condition: false

metaR GALU
reversible: true
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000134
modifier: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.9
name: UTP-glucose-1-phosphate uridylyltransferase
reactant: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y

metaR r0644
reversible: true
type: Reaction
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
is: SBO:0000176
product: MODEL1310110014#
is described by: ECO:0000000

metaM dpcoa c
is: CHEBI:57328
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: HMDB01373
constant: false
is: C00882
has only substance units: false
name: Dephospho-CoA

metaR r2132
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110014#
reversible: true
is: SBO:0000185
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110014#

metaM pnto R c
initial concentration: 1.0
is: CHEBI:7916
is: HMDB00210
name: (R)-Pantothenate
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
constant: false
is: SBO:0000247

metaR FAOXC16080x
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110014#
is described by: ECO:0000269
reactant: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaR AG13T8g
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110014#
reversible: false
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
kinetic law: MODEL1310110014#
is described by: ECO:0000000
modifier: MODEL1310110014#
product: MODEL1310110014#

metaM ddeccrn e
name: lauroyl carnitine
is: HMDB02250
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C19H37NO4 CHARGE: 0
is: SBO:0000247
boundary condition: false

metaR M7MASNBterg
fast: false
product: MODEL1310110014#
type: Reaction
is: SBO:0000185
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110014#
name: m7masnB transport from endoplasmic reticulum to Golgi apparatus
reactant: MODEL1310110014#

metaR r0838
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110014#
reversible: true
reactant: MODEL1310110014#
modifier: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.2.4
type: Reaction
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
name: Free diffusion

metaM 2obut c
boundary condition: false
is: C00109
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00005
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
constant: false
is: CHEBI:16763
name: 2-Oxobutanoate
type: Species

metaM pristanal x
name: pristanal
has only substance units: false
is: SBO:0000247
is: HMDB01958
initial concentration: 1.0
is: CHEBI:49189
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C19H38O CHARGE: 0 INCHI: InChI=1S/C19H38O/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20/h15-19H,6-14H2,1-5H3
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_847ea841_3cec_4341_a5bb_a496120d62a8
has only substance units: false
boundary condition: true
is: O95436
is: SBO:0000252
constant: false
initial concentration: NaN
name: SLC34A2
type: Species
initial amount: NaN
is encoded by: hsa:10568

metaR C204CPT2
is: SBO:0000176
type: Reaction
reactant: MODEL1310110014#
fast: false
modifier: MODEL1310110014#
reversible: false
name: arachidonic acid transport into the mitochondria
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport

http://identifiers.org/biomodels.db/MODEL1310110014#_31b08931_f9ba_40bd_a4d7_20b52f2b8537
initial concentration: NaN
boundary condition: true
name: PCYT1A
type: Species
is: P49585
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:5130
is: SBO:0000252

metaR r0839
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
reversible: true
name: Postulated transport reaction
modifier: MODEL1310110014#
is described by: ECO:0000000
kinetic law: MODEL1310110014#
fast: false
is: SBO:0000185
product: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.3.1.70

metaR BTNDe
is version of: http://identifiers.org/ec-code/3.5.1.12
kinetic law: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT
is: SBO:0000176
reactant: MODEL1310110014#
is described by: ECO:0000269
modifier: MODEL1310110014#
name: biotinidase (biotin), extracellular
fast: false
product: MODEL1310110014#
type: Reaction

metaR r2131
reversible: true
fast: false
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110014#
is: SBO:0000185
reactant: MODEL1310110014#
product: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_baf7b520_d0ee_4ee8_8935_ec580fb998c2
constant: false
is: SBO:0000252
name: _BF195998_1_x
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:BF195998
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_123a02e8_3597_453a_a0dc_e2319d24f5d7
constant: false
is encoded by: hsa:2731
initial amount: NaN
has only substance units: false
is: P23378
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: GLDC

metaR F1Atg
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
name: F1alpha transport (from golgi to lysosome)
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true

metaR OCD11CRNCACT
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR AG13T17g
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110014#
reversible: false
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
product: MODEL1310110014#
is: SBO:0000176

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaM pnto R e
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:7916
name: (R)-Pantothenate
is: HMDB00210
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_ddcda17e_5d18_487c_b9d7_6a2f49387c19
is: SBO:0000252
type: Species
is: O15488
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:8908
name: GYG2
has only substance units: false
initial concentration: NaN

metaR r1912
reversible: false
is: SBO:0000185
modifier: MODEL1310110014#
name: Y+LAT2 Utilized transport
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#

metaR ADPtx
fast: false
is: SBO:0000185
reactant: MODEL1310110014#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is described by: ECO:0000000
kinetic law: MODEL1310110014#
product: MODEL1310110014#
name: ADP transporter, peroxisomal

metaR r2130
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110014#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110014#
product: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_c13c431b_08d8_4ac6_95d5_2ec4983d865a
type: Species
name: PDE10A
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10846
boundary condition: true
is: Q9Y233

metaM pacald c
constant: false
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
type: Species
boundary condition: false
name: phenylacetaldehyde
is: CHEBI:16424
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB06236
initial concentration: 1.0

metaM arachd r
constant: false
has only substance units: false
boundary condition: false
name: arachidonate
initial amount: NaN
is: HMDB01043
initial concentration: 1.0
is: CHEBI:32395
type: Species
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: SBO:0000247

metaM xol7ah2 m
initial amount: NaN
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha-diol
has only substance units: false
is: CHEBI:28047
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: HMDB06893

http://identifiers.org/biomodels.db/MODEL1310110014#_c3017df3_1ebb_49a0_a900_cd4b421fc833
constant: false
is: P24752
is: SBO:0000252
initial concentration: NaN
name: ACAT1
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:38

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

metaR EX glyc S LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (S)-Glycerate exchange
type: Reaction

metaM CE2435 m
is: SBO:0000247
type: Species
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
has only substance units: false
initial concentration: 1.0
name: trans,cis-deca-2,4-dienoyl-CoA
is: CHEBI:57795
constant: false
boundary condition: false
initial amount: NaN

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaR FAOXC10C10OHm
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->OHC10)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_df5d241e_d6c9_414e_938c_c1c9faa4b82e
is: P51687
is encoded by: hsa:6821
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: SUOX
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_f2dbcbb3_0b75_49b7_bb3a_d2d4e140a11e
name: GPX6
is encoded by: hsa:257202
is: P59796
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_dff64661_e543_4ef8_83eb_066a489dad11
has only substance units: false
name: ALG8
boundary condition: true
is encoded by: hsa:79053
initial concentration: NaN
type: Species
is: A6NDW6
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_f2ca039f_f4e1_478d_8fe1_b0d16d43f874
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
name: SLC33A1
is encoded by: hsa:9197
is: O00400
initial amount: NaN

metaR NTP3e
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
reversible: false
reactant: MODEL1310110014#
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
product: MODEL1310110014#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.6
name: nucleoside-triphosphatase (GTP)

metaR CHOLtu
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
name: Choline uniport
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000269
product: MODEL1310110014#
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110014#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_01868ab3_a307_490e_8cef_1c20ae94d3d0
is encoded by: hsa:H17063
is: SBO:0000252
constant: false
name: _H17063_1_m
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true

metaM ksi pre18 g
type: Species
notes: FORMULA: C163H262N11O132S5X CHARGE: -6
is: CHEBI:58053
is: HMDB00175
initial amount: NaN
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 18
boundary condition: false
is: SBO:0000247
constant: false
is: C00130
initial concentration: 1.0

metaM hdcea e
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB03229
constant: false
initial amount: NaN
is: CHEBI:32372
name: Hexadecenoate (n-C16:1)

metaR G14T21g
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000176
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is described by: ECO:0000000

metaR r0834
is version of: http://identifiers.org/ec-code/3.5.4.16
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: SBO:0000185
modifier: MODEL1310110014#
reversible: true
reactant: MODEL1310110014#
fast: false
type: Reaction
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110014#

metaM hcys L c
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
is: HMDB00742
boundary condition: false
name: L-homocysteine
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17588
is: SBO:0000247

metaR r0638
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reversible: true
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110014#
fast: false
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.1.2
product: MODEL1310110014#

metaR RE2541E
product: MODEL1310110014#
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: RE2541
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.31
reactant: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
reversible: true

metaR NADN
product: MODEL1310110014#
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.2.2.5 Confidence Level: 2 AUTHORS: PMID:8382685 NOTES:
kinetic law: MODEL1310110014#
name: NAD nucleosidase

metaR r0424
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true
type: Reaction
product: MODEL1310110014#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is version of: http://identifiers.org/ec-code/1.17.1.4
fast: false
modifier: MODEL1310110014#
is described by: ECO:0000000

metaR r2136
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
is described by: ECO:0000000
reversible: false
type: Reaction
product: MODEL1310110014#
fast: false

metaR EX hexc LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexacosanoate (n-C26:0) exchange
type: Reaction

metaM 3otdcoa m
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
name: 3-Oxotetradecanoyl-CoA
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:28726
is: HMDB03935
constant: false
type: Species

metaM ca2 e
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
constant: false
type: Species
has only substance units: false
name: calcium(2+)
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00464
is: SBO:0000247
is: CHEBI:29108

metaR FE2tm
reactant: MODEL1310110014#
is: SBO:0000185
product: MODEL1310110014#
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110014#
name: iron (II) transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10383398,PMID:12755454 NOTES:TDV Lange H, 1999.

http://identifiers.org/biomodels.db/MODEL1310110014#_3e89de82_ce79_4ce6_a4a0_e51a0dc46580
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:8876
initial concentration: NaN
is: O95497
has only substance units: false
is: SBO:0000252
name: VNN1
boundary condition: true

metaR HSAT2ly
is described by: ECO:0000000
reversible: false
fast: false
name: heparan-glucosaminide N-acetyltransferase, lysosomal
product: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
type: Reaction
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_7d682894_f34a_412e_9b26_cd8ebe4bc37e
is: SBO:0000252
has only substance units: false
name: SGPP2
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is: Q8IWX5
is encoded by: hsa:130367
constant: false

metaR GLYCt
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
name: glycerol transport via channel
product: MODEL1310110014#
type: Reaction

metaM adpcoa x
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB04047
boundary condition: false
constant: false
has only substance units: false
name: adipoylcoa
is: C14143
notes: FORMULA: C27H39N7O19P3S CHARGE: -5

http://identifiers.org/biomodels.db/MODEL1310110014#_0508c8fa_f2ad_427d_9c0a_b7917cb8e0e5
type: Species
initial amount: NaN
is encoded by: hsa:56922
is encoded by: hsa:64087
has part: Q9HCC0
initial concentration: NaN
constant: false
is: SBO:0000297
has only substance units: false
boundary condition: true
name: MCCC1:MCCC2
has part: Q96RQ3

metaM glu L c
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00148
type: Species
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
name: L-glutamate(1-)
is: CHEBI:29985
has only substance units: false
is: SBO:0000247

metaM c10dc c
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C17H30NO6 CHARGE: -1
has only substance units: false
name: sebacoyl carnitine
is: HMDB00651
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR r0835
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
product: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
modifier: MODEL1310110014#
reversible: true
kinetic law: MODEL1310110014#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.16

metaR r0425
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.1.4
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000176
fast: false
name: EC:1.1.1.42

metaR r0639
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110014#
is described by: ECO:0000000
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
product: MODEL1310110014#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_c10f426a_6201_43a7_a315_b87fa4f38419
boundary condition: true
is encoded by: hsa:9498
name: SLC4A8
is: E7EML0
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_3484579a_6b35_4007_8b41_a9a30753692b
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5150
name: PDE7A
is: SBO:0000252
type: Species
has only substance units: false

metaR 2MCITt
product: MODEL1310110014#
reversible: true
is described by: ECO:0000000
name: 2-methylcitrate transport via diffusion
kinetic law: MODEL1310110014#
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:426765 NOTES:MM

metaM galgluside hs g
initial concentration: 1.0
is: HMDB00295
is: C00015
initial amount: NaN
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
constant: false
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:58223
name: galactosyl glucosyl ceramide
has only substance units: false

metaM hdcea c
type: Species
constant: false
has only substance units: false
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
boundary condition: false
is: SBO:0000247
is: HMDB03229
is: CHEBI:32372
initial concentration: 1.0
initial amount: NaN
name: Hexadecenoate (n-C16:1)

metaM bildglcur c
is: CHEBI:58471
constant: false
name: bis(beta-glucosyluronate)bilirubin
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: HMDB03325
is: SBO:0000247
initial amount: NaN

metaR PACCOAL
fast: false
product: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
name: phenylacetate-CoA ligase
kinetic law: MODEL1310110014#
type: Reaction
reversible: false

metaM ddeccrn c
name: lauroyl carnitine
is: HMDB02250
constant: false
notes: FORMULA: C19H37NO4 CHARGE: 0
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_ae2acf65_c184_4fea_82aa_eb57bbae5364
is: P11310
constant: false
boundary condition: true
name: ACADM
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:34

metaR EX c3dc
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for malonyl carnitine
type: Reaction

metaR r0426
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.5.1.34
type: Reaction
kinetic law: MODEL1310110014#
reversible: true
product: MODEL1310110014#
fast: false
is described by: ECO:0000000
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is: SBO:0000176

metaM 2dr1p c
boundary condition: false
type: Species
is: HMDB01351
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58576
is: C00672
constant: false
is: SBO:0000247
name: 2-Deoxy-D-ribose 1-phosphate
has only substance units: false

metaR RE1807M
reversible: true
product: MODEL1310110014#
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.14.13.15
name: RE1807
fast: false
type: Reaction
kinetic law: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is: SBO:0000176

metaM 3ivcoa m
initial concentration: 1.0
type: Species
boundary condition: false
is: C05998
is: HMDB06870
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/11966188
name: 3-hydroxyisovalerylcoa
notes: FORMULA: C26H40N7O18P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110014#_6b7e9884_d3bb_4aff_9ca6_cdb76c42e44e
is encoded by: hsa:1738
constant: false
is: P09622
is: SBO:0000252
type: Species
name: DLD
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR HYXNt
name: Hypoxanthine transport
is: SBO:0000185
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
fast: false
product: MODEL1310110014#
modifier: MODEL1310110014#
reversible: true
is described by: ECO:0000269

metaR SCP22x
type: Reaction
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.176
kinetic law: MODEL1310110014#
reversible: true
fast: false
reactant: MODEL1310110014#
name: Sterol carrier protein 2
modifier: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ

metaR NRPPHRtu
type: Reaction
kinetic law: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
name: Norepinephrine uniport
modifier: MODEL1310110014#
is described by: ECO:0000269
product: MODEL1310110014#
fast: false
reactant: MODEL1310110014#

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

metaR C162ACBP
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxy trans7,10-hexadecadienoylcoa from mitochondria into cytosol
type: Reaction

metaR r1052
is: SBO:0000185
reversible: false
name: Vesicular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
product: MODEL1310110014#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_92f5b150_bb3e_4e72_970a_2c5c191f3c37
constant: false
name: _AI697028_1_m
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:AI697028
has only substance units: false
is: SBO:0000252

metaR 41R2A1H12BOOX
is version of: http://identifiers.org/ec-code/1.4.3.4
modifier: MODEL1310110014#
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
name: 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
product: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000269
type: Reaction

metaR UGT1A10r
fast: false
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
kinetic law: MODEL1310110014#
product: MODEL1310110014#
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
is described by: ECO:0000134
modifier: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.17
is: SBO:0000176
reversible: true

metaM acglcgal14acglcgalgluside hs g
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
constant: false
is: CHEBI:17103
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: nLc5Cer

http://identifiers.org/biomodels.db/MODEL1310110014#_d950c138_b491_4a7c_88ec_4a3d65c67ce6
has only substance units: false
boundary condition: true
constant: false
type: Species
is: C9JC79
name: SCP2
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6342
initial concentration: NaN

metaR r2133
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110014#
type: Reaction
fast: false
reversible: true

metaM duri n
type: Species
has only substance units: false
is: HMDB00012
name: 2'-deoxyuridine
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:16450
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
constant: false

metaR FE2DMT1
is described by: ECO:0000134
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (4891.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
product: MODEL1310110014#
reversible: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
name: uptake of food iron by DMT1 transporter

metaM tcynt c
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
has only substance units: false
is: SBO:0000247
name: thiocyanate
is: CHEBI:18022
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB01453
constant: false

metaM ksi pre2 g
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00175
initial amount: NaN
has only substance units: false
notes: FORMULA: C87H142N6O62X CHARGE: -1
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 2
boundary condition: false
constant: false
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110014#_dd59691e_d130_479b_adc6_ee19578acd1c
initial concentration: NaN
is encoded by: hsa:10449
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
name: ACAA2
is: P42765
type: Species

metaM 13dpg c
is: CHEBI:57604
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
is: HMDB01270
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
is: C00236
is: http://identifiers.org/pubchem.compound/3535
name: 3-Phospho-D-glyceroyl phosphate
constant: false
initial amount: NaN

metaM dopa c
constant: false
initial amount: NaN
is: HMDB00073
type: Species
name: dopaminium(1+)
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:59905
is: SBO:0000247

metaR XOLTRIOLtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
name: lipid, flip-flop intracellular transport
reversible: true
reactant: MODEL1310110014#
fast: false
is described by: ECO:0000000
product: MODEL1310110014#
is: SBO:0000185
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_1d6193b3_d61d_4187_a47c_a2d957bdb3c9
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: E9PCI1
constant: false
name: ACP2
is encoded by: hsa:53
has only substance units: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_af12159d_58bc_48c0_8b95_eaa7e485f560
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:126129
name: CPT1C
is: Q8TCG5

metaM pmtcoa m
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
name: Palmitoyl-CoA (n-C16:0CoA)
is: HMDB01338
type: Species
is: C00154
boundary condition: false
is: CHEBI:57379

metaR SBT Dtde
name: D-sorbitol transport, extracellular
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
product: MODEL1310110014#
is described by: ECO:0000134
reactant: MODEL1310110014#
type: Reaction
reversible: true
kinetic law: MODEL1310110014#

metaR P4502C92
kinetic law: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1559.1) or (1557.1) SUBSYSTEM: Limonene and pinene degradation EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:11950794,PMID:11996015 NOTES:assumed to take place on outer membrane NJ
is version of: http://identifiers.org/ec-code/1.14.13.48
type: Reaction
name: cytochrome P450 2C9
product: MODEL1310110014#
fast: false
reactant: MODEL1310110014#

metaR DOPASULT
reactant: MODEL1310110014#
name: Dopamine Sulfotransferase
fast: false
modifier: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.1
reversible: false
product: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)

metaR sink dd2coa LPAREN c RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: DD2COASINK
type: Reaction

metaM 4h2oglt m
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
boundary condition: false
constant: false
is: HMDB02070
type: Species
is: CHEBI:17742
name: 4-hydroxy-2-oxoglutarate(2-)
initial amount: NaN
initial concentration: 1.0

metaR GNMT
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (27232.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.1.20 Confidence Level: 4 AUTHORS: PMID:10843803,PMID:11810299 NOTES:
kinetic law: MODEL1310110014#
name: glycine N-methyltransferase
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110014#
reversible: false
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.1.1.20
reactant: MODEL1310110014#

metaM tcynt e
boundary condition: false
initial concentration: 1.0
is: HMDB01453
type: Species
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: SBO:0000247
is: CHEBI:18022
initial amount: NaN
constant: false
has only substance units: false
name: thiocyanate

metaR FAOXC181C161x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C18:1-->C16:1)x
type: Reaction

metaR BTNDm
name: biotinidase (biotin), mitochondrial
reactant: MODEL1310110014#
is: SBO:0000176
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
is version of: http://identifiers.org/ec-code/3.5.1.12
fast: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110014#
reversible: false
product: MODEL1310110014#

metaR r2320
product: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction

metaR r2139
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110014#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110014#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true

metaR G14T10g
is: SBO:0000176
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reactant: MODEL1310110014#
product: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_b596d1db_ba46_44dd_b94d_5c95f965e000
is: Q9HAW8
name: UGT1A10
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:54575
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_fc2764a0_37a1_4002_ac4a_a08a52f28de5
is: O94777
boundary condition: true
type: Species
name: DPM2
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8818
has only substance units: false
constant: false
is: SBO:0000252

metaM glu L e
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00148
boundary condition: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
name: L-glutamate(1-)
is: CHEBI:29985

metaM leuktrE4 c
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
name: leukotriene E4(1-)
is: HMDB02200
is: CHEBI:57462
constant: false

metaM pan4p e
has only substance units: false
is: SBO:0000247
name: Pantetheine 4'-phosphate
type: Species
initial amount: NaN
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: CHEBI:47942
boundary condition: false
is: HMDB01416
is: C01134
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110014#_b0694c9c_4677_4483_a0dd_237fb53ad8c5
type: Species
is encoded by: hsa:29958
is: SBO:0000252
has only substance units: false
name: DMGDH
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: B3KQ84

http://identifiers.org/biomodels.db/MODEL1310110014#_5cee920c_1adf_42ed_8652_aeed0c416be9
constant: false
boundary condition: true
is: O75489
has only substance units: false
is encoded by: hsa:4722
type: Species
name: NDUFS3
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

metaM sphgn c
name: sphinganine(1+)
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
is: HMDB00269
constant: false
is: CHEBI:57817

metaR r0422
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110014#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110014#
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_e7e0a54a_6f59_4721_8001_a6611f28f196
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: SLC26A1
constant: false
boundary condition: true
is encoded by: hsa:10861
type: Species

metaR SUCRe
reactant: MODEL1310110014#
name: sucrose hydrolyzing enxyme, extracellular
is described by: ECO:0000269
fast: false
is: SBO:0000176
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.10
notes: GENE_ASSOCIATION: (6476.1) or (8972.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.26 Confidence Level: 4 AUTHORS: PMID:1560017,PMID:3143729 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.20
modifier: MODEL1310110014#
reversible: false

metaR r2321
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110014#
reversible: true
reactant: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110014#
fast: false

metaM ca2 c
boundary condition: false
initial amount: NaN
is: HMDB00464
initial concentration: 1.0
name: calcium(2+)
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
type: Species
is: CHEBI:29108

metaM ksi pre10 g
has only substance units: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 10
is: C00130
is: CHEBI:58053
initial concentration: 1.0
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: HMDB00175

metaR RE1525M
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE1525
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false

metaM glyclt x
boundary condition: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
name: glycolate
is: CHEBI:29805
is: SBO:0000247
initial amount: NaN
is: HMDB00115
type: Species
has only substance units: false
constant: false
initial concentration: 1.0

metaR FAOXC17C15m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C17-->C15)m
type: Reaction

metaM estradiolglc c
is: CHEBI:36489
boundary condition: false
notes: FORMULA: C24H32O8 CHARGE: 0 INCHI: InChI=1S/C24H32O8/c1-24-9-8-14-13-5-3-12(10-11(13)2-4-15(14)16(24)6-7-17(24)25)31-23-20(28)18(26)19(27)21(32-23)22(29)30/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30)/t14-,15-,16+,17+,18+,19+,20-,21+,23-,24+/m1/s1
has only substance units: false
is: HMDB06224
initial amount: NaN
initial concentration: 1.0
name: 17beta-estradiol 3-glucosiduronic acid
type: Species
is: SBO:0000247
constant: false

metaR GK1
modifier: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.8
fast: false
name: guanylate kinase (GMP:ATP)
type: Reaction
product: MODEL1310110014#

metaR FACOAL161
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110014#
name: fatty-acid--CoA ligase (hexadecenoate)
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110014#
modifier: MODEL1310110014#
reactant: MODEL1310110014#

metaR r0423
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110014#
is described by: ECO:0000000
modifier: MODEL1310110014#
is: SBO:0000176
reversible: true

metaR FAOXC205C184x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:4)x
type: Reaction

metaR NACHEXA18ly
is described by: ECO:0000000
fast: false
reactant: MODEL1310110014#
reversible: false
name: beta-N-acetylhexosaminidase A, lysosomal
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
type: Reaction
is: SBO:0000176

metaR r2137
product: MODEL1310110014#
modifier: MODEL1310110014#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110014#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
reactant: MODEL1310110014#

metaM 2obut m
is: HMDB00005
has only substance units: false
name: 2-oxobutanoate
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:16763
boundary condition: false
initial amount: NaN

metaR NACHEX23ly
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#
is described by: ECO:0000000
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
fast: false
reactant: MODEL1310110014#

metaR FAOXC142C142OHm
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C14:2OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_c6791ec2_cb15_4e85_830c_5a7cdbd95bab
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:8560
name: DEGS1
boundary condition: true
initial amount: NaN

metaR r2322
is: SBO:0000185
product: MODEL1310110014#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110014#
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR NACHEX10ly
kinetic law: MODEL1310110014#
is: SBO:0000176
fast: false
reversible: false
reactant: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
modifier: MODEL1310110014#

metaR FAOXC162C162OHm
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:2-->C16:2OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_07d3aa03_f127_480c_a953_e0c721f282de
initial amount: NaN
has only substance units: false
name: PGK2
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:5232
is: P07205

metaR RE1691M
fast: false
product: MODEL1310110014#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
is: SBO:0000176
name: RE1691
is version of: http://identifiers.org/ec-code/2.8.1.1
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:

metaR PROt2r
is: SBO:0000185
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
fast: false
reversible: true
name: L-proline reversible transport via proton symport
product: MODEL1310110014#
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_b5593003_0b67_4ebe_9a4b_4e1d3ade8b3e
is: SBO:0000252
type: Species
is: P51857
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: AKR1D1
constant: false
has only substance units: false
is encoded by: hsa:6718

metaM utp n
has only substance units: false
name: UTP(4-)
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:46398
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: HMDB00285
is: SBO:0000247

metaM leuktrE4 e
initial amount: NaN
boundary condition: false
constant: false
type: Species
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
initial concentration: 1.0
name: leukotriene E4(1-)
is: CHEBI:57462
has only substance units: false
is: HMDB02200
is: SBO:0000247

metaR NAGLCAly
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
type: Reaction
product: MODEL1310110014#
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000000
reversible: false
name: N-acetylglucosaminidase, lysosomal
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110014#_bebc3813_0cc8_4c24_9503_2b540a8ef9c5
name: INPP5J
is: SBO:0000252
constant: false
is encoded by: hsa:27124
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR CHOLtn
reactant: MODEL1310110014#
product: MODEL1310110014#
name: Choline transport, nuclear through pores
type: Reaction
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110014#_671a6eb0_9ec4_4fe7_af49_a0dbd5636ebb
constant: false
initial amount: NaN
is: P61457
is encoded by: hsa:5092
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
name: PCBD1

metaM pan4p c
is: C01134
has only substance units: false
constant: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
name: Pantetheine 4'-phosphate
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB01416
is: CHEBI:47942
type: Species
initial amount: NaN

metaM orot c
is: C00295
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
boundary condition: false
is: SBO:0000247
is: HMDB00226
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:30839
name: Orotate

metaM Ser Gly Ala X Gly l
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: protein-linked serine residue (glycosaminoglycan attachment site)
boundary condition: false
notes: FORMULA: XH CHARGE: 0
is: CHEBI:36005
is: HMDB02183
constant: false
type: Species

metaR NDP8
product: MODEL1310110014#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
modifier: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.7.4.9
reactant: MODEL1310110014#
name: nucleoside-diphosphatase (dUDP)
reversible: false

metaM arachd c
type: Species
is: HMDB01043
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
name: arachidonate
constant: false
is: SBO:0000247
is: CHEBI:32395
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_28fb3505_9b0b_4c1c_a7ff_bc2f6f6e3325
initial concentration: NaN
has only substance units: false
type: Species
name: TXNRD1
is: SBO:0000252
is encoded by: hsa:7296
constant: false
boundary condition: true
initial amount: NaN

metaR GALASE20ly
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
type: Reaction
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110014#

metaR RE1527M
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
fast: false
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110014#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
name: RE1527
type: Reaction

metaR r2323
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
kinetic law: MODEL1310110014#
fast: false
product: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true

metaM estradiolglc e
has only substance units: false
is: HMDB06224
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C24H32O8 CHARGE: 0 INCHI: InChI=1S/C24H32O8/c1-24-9-8-14-13-5-3-12(10-11(13)2-4-15(14)16(24)6-7-17(24)25)31-23-20(28)18(26)19(27)21(32-23)22(29)30/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30)/t14-,15-,16+,17+,18+,19+,20-,21+,23-,24+/m1/s1
is: CHEBI:36489
type: Species
boundary condition: false
initial concentration: 1.0
name: 17beta-estradiol 3-glucosiduronic acid

metaR EX galacglcgalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Gal-GlcNAc-Gal globoside (homo sapiens) exchange
type: Reaction

metaM arachd e
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
type: Species
name: arachidonate
is: CHEBI:32395
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01043
has only substance units: false
boundary condition: false

metaR SARDHm
is: SBO:0000176
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
name: Sarcosine dehydrogenase (m)
is version of: http://identifiers.org/ec-code/1.5.99.1
fast: false
kinetic law: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000269
reactant: MODEL1310110014#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_f9728654_a74e_40cb_92a8_f6a4c34b27ec
is: SBO:0000252
type: Species
name: HADH
is encoded by: hsa:3033
is: Q16836
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false

metaM HC01602 c
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
name: 10-Formyltetrahydrofolate
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
is: C00234

metaR ACRNtm
fast: false
is: SBO:0000185
is described by: ECO:0000269
name: O-acetylcarnintine transport into mitochondria via diffusion
kinetic law: MODEL1310110014#
product: MODEL1310110014#
modifier: MODEL1310110014#
reversible: false
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:977593 NOTES:NCD
type: Reaction

metaM ethamp r
initial amount: NaN
constant: false
is: CHEBI:58190
initial concentration: 1.0
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
name: O-phosphonatoethanaminium(1-)
is: HMDB00224
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM ser L x
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00187
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: SBO:0000247
constant: false
has only substance units: false
name: L-serine
is: CHEBI:17115

http://identifiers.org/biomodels.db/MODEL1310110014#_b49b19bf_6793_4988_970d_41974a4c73a0
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: Q6FG42
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4701
name: NDUFA7

metaM 3tdcrn e
is: SBO:0000247
type: Species
initial concentration: 1.0
name: 3-hydroxy-tetradecanoyl carnitine
boundary condition: false
is: HMDB13336
has only substance units: false
notes: FORMULA: C21H41NO5 CHARGE: 0
constant: false
initial amount: NaN

metaM duri c
boundary condition: false
type: Species
is: CHEBI:16450
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00012
initial amount: NaN
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
name: Deoxyuridine
has only substance units: false
is: C00526

metaM prostgh2 c
is: HMDB01381
is: CHEBI:57405
is: SBO:0000247
constant: false
name: prostaglandin H2(1-)
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial amount: NaN
type: Species

metaR CLPNDt
fast: false
product: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110014#
reversible: true
name: fatty acid transport via diffusion
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaM am6sa c
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
name: 2-aminomuconate 6-semialdehyde(1-)
is: SBO:0000247
is: HMDB01280
is: CHEBI:57495
constant: false
notes: FORMULA: C6H7NO3 CHARGE: 0 INCHI: InChI=1S/C6H7NO3/c7-5(6(9)10)3-1-2-4-8/h1-4H,7H2,(H,9,10)/p-1/b2-1-,5-3+ HEPATONET_1.0_ABBREVIATION: HC01186 EHMN_ABBREVIATION: C03824

metaR FAOXC18C18OHm
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18-->C18OH)m
type: Reaction

metaR r2324
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110014#
fast: false
product: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185

metaM ametam c
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137
is: CHEBI:57443
name: S-Adenosylmethioninamine
is: C01137
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00988
has only substance units: false

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaM orot e
is: CHEBI:30839
has only substance units: false
is: HMDB00226
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: orotate
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
type: Species
constant: false
boundary condition: false

metaM dopa e
is: HMDB00073
constant: false
is: SBO:0000247
name: dopaminium(1+)
has only substance units: false
type: Species
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
boundary condition: false
is: CHEBI:59905
initial concentration: 1.0
initial amount: NaN

metaM 5tedtricoa m
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
initial concentration: 1.0
name: 5,8,11-tetradecatrienoylcoa
constant: false
is: HMDB02288

http://identifiers.org/biomodels.db/MODEL1310110014#_fe12de92_483a_4e03_9199_4a0ad2e8affc
constant: false
initial concentration: NaN
is: F6KD01
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5728
name: PTEN

metaR FUT17g
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
name: Galactoside 2-alpha-L-fucosyltransferase 1
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.69
is: SBO:0000176
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110014#_11d4eacc_16f8_4cc5_8c83_eda7cc53365c
initial concentration: NaN
type: Species
is encoded by: hsa:10998
name: SLC27A5
initial amount: NaN
has only substance units: false
constant: false
is: Q9Y2P5
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_dcf10d54_4034_4048_ba7f_93dc6388b088
is: P23634
name: ATP2B4
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:493
boundary condition: true
type: Species

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_99748f4d_09c7_43d6_9c97_d816c5954645
constant: false
is: B3KMA6
type: Species
initial amount: NaN
name: ACSL3
boundary condition: true
is encoded by: hsa:2181
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR GLGNS1
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8908.1) and (2997.1) or (2998.1) and (2992.1) or (2997.1) and (2992.1) or (8908.1) and (2998.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 2.4.1.11 Confidence Level: 2 AUTHORS: PMID:15238248 NOTES:NCD
kinetic law: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
reversible: false
product: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.11
is version of: http://identifiers.org/ec-code/2.4.1.186
name: glycogen synthase (ggn -> glygn1)

http://identifiers.org/biomodels.db/MODEL1310110014#_c407ea8e_f455_4faf_949d_cfc3121ea28d
is: Q01968
initial amount: NaN
name: OCRL
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4952
type: Species
initial concentration: NaN

metaR r2325
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000185
product: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_e14d349d_cedd_4b33_9b5d_1a7af818f120
type: Species
constant: false
is encoded by: hsa:2194
is: P49327
has only substance units: false
is: SBO:0000252
name: FASN
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR TXASr
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.99.5
reversible: false
fast: false
name: Thromboxane-A synthase
product: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110014#_5b4491b3_fe4f_40e1_8a2e_99e04309ad03
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: A8K9Q8
is: SBO:0000252
is encoded by: hsa:192134
name: B3GNT6
constant: false
initial concentration: NaN

metaR EHGLATm
reactant: MODEL1310110014#
is described by: ECO:0000212
modifier: MODEL1310110014#
fast: false
type: Reaction
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
kinetic law: MODEL1310110014#
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110014#

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

metaM 3tdcrn c
notes: FORMULA: C21H41NO5 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB02014
name: 3-hydroxy-tetradecanoyl carnitine
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_6e32afb0_9861_4d42_9b14_75fb56f0c2f2
constant: false
name: CDO1
initial amount: NaN
has only substance units: false
is: Q16878
boundary condition: true
type: Species
is encoded by: hsa:1036
initial concentration: NaN
is: SBO:0000252

metaR NACHEX12ly
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
fast: false

metaM 2docopencoa x
is: http://identifiers.org/pubchem.compound/24892790
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 2,7,10,13,16-docosapentenoylcoa
has only substance units: false
constant: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110014#_5612a8c7_22f3_4831_8fde_1a1173ce0adf
initial amount: NaN
name: UGP2
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:7360
constant: false
is: SBO:0000252

metaR r2326
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
fast: false
reactant: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
is: SBO:0000185
product: MODEL1310110014#

metaM duri e
name: Deoxyuridine
is: CHEBI:16450
is: C00526
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00012

metaM pmtcoa r
boundary condition: false
constant: false
type: Species
is: CHEBI:3454
is: HMDB01338
initial concentration: 1.0
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
name: Palmitoyl-CoA (n-C16:0CoA)
is: C00154
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR RE1807C
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
name: RE1807
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#

metaR FAOXC12DCx
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanedioyl carnitine
type: Reaction

metaR PHETHPTOX2
is described by: ECO:0000269
modifier: MODEL1310110014#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
fast: false
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.14.16.1
product: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395

http://identifiers.org/biomodels.db/MODEL1310110014#_2dbab3d3_1919_43ce_8bde_086593ef52a0
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:AV727634
name: _AV727634_1_c
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaM CE5160 r
is: CHEBI:57923
constant: false
initial amount: NaN
name: 3-oxo-cis-9-octadecenoyl-CoA
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_c038c7b7_2655_4265_9d5f_88c4830709d9
initial amount: NaN
has only substance units: false
is encoded by: hsa:6531
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: SLC6A3
is: Q01959
type: Species
constant: false

metaR r1492
name: Utilized transport
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaR CDPDAGtm
product: MODEL1310110014#
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
reversible: true
reactant: MODEL1310110014#
name: intracellular transport

metaM CE5119 m
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
is: CHEBI:57923
has only substance units: false
type: Species
name: trans-3-cis-8-tetradecadienoyl-CoA
initial amount: NaN

metaM CE2420 m
type: Species
initial concentration: 1.0
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
initial amount: NaN
constant: false
is: CHEBI:28387
boundary condition: false
is: HMDB11123
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_d8551b94_0746_49c0_90af_529a0f46b252
is: Q9UNA3
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
name: A4GNT
initial concentration: NaN
type: Species
is encoded by: hsa:51146

metaM fmn c
is: HMDB01520
name: FMN
type: Species
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
initial amount: NaN
is: CHEBI:58210
constant: false
initial concentration: 1.0
has only substance units: false
is: C00061
boundary condition: false
is: SBO:0000247

metaM prgnlone c
is: HMDB00253
initial amount: NaN
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953
is: SBO:0000247
initial concentration: 1.0
constant: false
name: pregnenolone
boundary condition: false
type: Species
is: CHEBI:16581
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_da2b58d5_a5c8_49a9_ae93_af11704115ce
is encoded by: hsa:6817
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: SULT1A1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_749ae5e2_1add_4841_87bf_31e6f6c2f950
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8140
initial concentration: NaN
name: SLC7A5
has only substance units: false
boundary condition: true
is: Q8IV97
type: Species
constant: false

metaM ppp9 m
has only substance units: false
initial amount: NaN
type: Species
name: Protoporphyrin
notes: FORMULA: C34H32N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00905 EHMN_ABBREVIATION: C02191
initial concentration: 1.0
is: CHEBI:36159
is: SBO:0000247
boundary condition: false
is: HMDB00241
constant: false

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

metaM glu L m
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: HMDB00148
initial amount: NaN
is: CHEBI:29985
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
name: L-glutamate(1-)
is: SBO:0000247
has only substance units: false

metaM pmtcoa x
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
name: Palmitoyl-CoA (n-C16:0CoA)
is: C00154
boundary condition: false
is: CHEBI:57379
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: HMDB01338

metaM HC02202 e
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: prostaglandin A1(1-)
is: CHEBI:57398
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
boundary condition: false

metaM lys L c
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
constant: false
type: Species
is: SBO:0000247
name: L-lysinium(1+)
is: HMDB00182
is: CHEBI:32551
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_7dafda4a_22d4_4c07_be86_ed7fae016aec
name: NDUFB10
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: A8K761
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4716
constant: false
type: Species

metaR C142CPT1
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecadienoylcarnitine
type: Reaction

metaM tddedi2coa m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: HMDB00792
is: SBO:0000247
boundary condition: false
is: C08277
name: trans2,6dodecadienoylcoa
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM gln L m
is: HMDB00641
boundary condition: false
name: L-glutamine
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: CHEBI:18050
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_499e1dbe_39b7_45ad_9338_4c671394c497
is encoded by: hsa:4695
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: O43678
type: Species
has only substance units: false
name: NDUFA2
constant: false

metaR KYNAKGAT
is version of: http://identifiers.org/ec-code/2.6.1.7
kinetic law: MODEL1310110014#
fast: false
is: SBO:0000176
name: L-Kynurenine:2-oxoglutarate aminotransferase
type: Reaction
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
product: MODEL1310110014#
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.6.1.64

metaR DOLMANP Lter
name: dolichol-phosphate mannose flippase (liver)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reversible: false
product: MODEL1310110014#
is: SBO:0000185
reactant: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110014#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_21b97e71_5492_4089_a417_6c3a82b080a1
name: DUOX2
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:50506
is: SBO:0000252
is: Q9NRD8

http://identifiers.org/biomodels.db/MODEL1310110014#_fdf11383_ab07_49bd_90c9_f3845b0a65c3
constant: false
boundary condition: true
name: _PRO1933_1_m
is encoded by: hsa:PRO1933
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_70e488c7_ab14_4a21_a664_49f37cc0c513
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:10246
name: SLC17A2
is: O00624

http://identifiers.org/biomodels.db/MODEL1310110014#_296e6822_3fb3_4209_955f_87cd427f6bd9
is: SBO:0000297
has only substance units: false
has part: Q86U05
initial concentration: NaN
name: SLC7A8:SLC3A2
is encoded by: hsa:23428
boundary condition: true
type: Species
initial amount: NaN
constant: false

metaR ODECOAtx
product: MODEL1310110014#
is described by: ECO:0000000
name: fatty acid intracellular transport
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
reactant: MODEL1310110014#
reversible: true
kinetic law: MODEL1310110014#

metaR PSt3
reversible: true
product: MODEL1310110014#
fast: false
is described by: ECO:0000269
name: phosphatidylserine transport
is: SBO:0000185
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_b24b8e1d_b6e4_4a64_b33e_dabb9434569b
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is: B3KT86
has only substance units: false
name: ADCY3
is encoded by: hsa:109

metaM nm2masn g
initial concentration: 1.0
constant: false
is: C05884
notes: FORMULA: C42H70N3O30X CHARGE: 0
has only substance units: false
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_73dfb695_96ec_40fd_966f_df43d71d8dbf
name: DAD1:DDOST:RPN1:RPN2
is encoded by: hsa:1603
has part: P04844
is encoded by: hsa:6184
initial concentration: NaN
constant: false
has part: Q53G02
type: Species
is: SBO:0000297
initial amount: NaN
has part: P39656
has part: P04843
has only substance units: false
boundary condition: true
is encoded by: hsa:1650
is encoded by: hsa:6185

http://identifiers.org/biomodels.db/MODEL1310110014#_a4705083_87de_4b15_9a58_440ba71e4aff
has only substance units: false
is encoded by: hsa:2530
is: Q9BYC5
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: FUT8
constant: false

metaR FAS140COA
type: Reaction
reactant: MODEL1310110014#
is described by: ECO:0000269
product: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
kinetic law: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#
name: fatty-acyl-CoA synthase (n-C14:0CoA)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_ed75e415_8986_4a31_834a_2555240d196f
initial amount: NaN
is: P48728
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:275
type: Species
name: AMT

metaR O2Stn
kinetic law: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
fast: false
reversible: true
type: Reaction
name: superoxide anion transport via diffusion (nucleus)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is: SBO:0000185
product: MODEL1310110014#

metaM 3aib m
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
initial amount: NaN
is: CHEBI:33094
has only substance units: false
is: HMDB02166
is: SBO:0000247
name: (S)-3-aminoisobutyric acid
boundary condition: false
type: Species
constant: false
initial concentration: 1.0

metaM dece3coa m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: 3-decenoylcoa
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
has only substance units: false

metaR r1177
name: EC:3.1.1.13
type: Reaction
fast: false
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
reversible: false
kinetic law: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110014#

metaM hdcea r
is: CHEBI:32372
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB03229
is: SBO:0000247
name: palmitoleate
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850

metaR GLYCTDle
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000185
name: difussion of glycerol accross the brush border membrane
reversible: true
is described by: ECO:0000134
product: MODEL1310110014#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_748a7cd6_f561_43da_aa8f_96cf56adf228
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is: P19623
name: SRM
is encoded by: hsa:6723
initial amount: NaN
has only substance units: false

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaR O2Stm
name: superoxide anion transport via diffusion (mitochondria)
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
kinetic law: MODEL1310110014#
reversible: true
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110014#
is described by: ECO:0000000

metaM glyclt c
has only substance units: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
is: HMDB00115
is: CHEBI:29805
is: SBO:0000247
initial concentration: 1.0
name: glycolate
boundary condition: false

metaR MI4PP
reversible: false
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.3.25
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110014#
product: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
name: myo-inositol 4-phosphatase
fast: false

metaM 3mop c
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
initial concentration: 1.0
is: HMDB00491
is: CHEBI:28654
boundary condition: false
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
has only substance units: false

metaR APAT2rm
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.19
is described by: ECO:0000212
reversible: true
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
is: SBO:0000176
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#

metaM pser L c
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: HMDB01721
name: O-Phospho-L-serine
is: SBO:0000247
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
has only substance units: false
is: CHEBI:15811
constant: false

metaR PROD2m
modifier: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.99.8
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
reversible: false
name: Proline dehydrogenase (m)
is: SBO:0000176

metaM xolest2 hs e
is: SBO:0000247
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
name: cholesterol ester
has only substance units: false
initial concentration: 1.0
is: CHEBI:17002
constant: false
initial amount: NaN
type: Species
boundary condition: false

metaR S6TASE12ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
modifier: MODEL1310110014#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_f815c51d_52c3_4ef8_ab48_48bcc0c99e9f
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
name: ACSL3
initial amount: NaN
is: O95573
is: SBO:0000252
constant: false
is encoded by: hsa:2181

http://identifiers.org/biomodels.db/MODEL1310110014#_9f634065_a215_4474_ad70_c98feaac8add
has part: Q6IBB5
has part: Q13454
has part: H7C5B8
is encoded by: hsa:4728
is encoded by: hsa:4535
has part: O14561
is encoded by: hsa:4707
has part: B7Z792
is encoded by: hsa:4726
is encoded by: hsa:4696
has only substance units: false
is encoded by: hsa:4700
is encoded by: hsa:4702
has part: P03915
has part: A8K761
is encoded by: hsa:4731
is encoded by: hsa:4537
is encoded by: hsa:4717
has part: P56556
has part: O95168
has part: O95139
has part: Q9Y6M9
has part: O95167
has part: Q16795
is encoded by: hsa:4695
is encoded by: hsa:4710
has part: P28331
is encoded by: hsa:4716
has part: P56181
has part: O00217
is encoded by: hsa:4723
is encoded by: hsa:7991
has part: Q7GXZ4
is encoded by: hsa:4725
has part: Q6IBC4
has part: F8VQS7
has part: Q549M5
is encoded by: hsa:4719
is encoded by: hsa:4709
is: SBO:0000297
has part: B1AM93
is encoded by: hsa:4720
has part: Q16718
has part: O43677
is encoded by: hsa:4706
is encoded by: hsa:4712
type: Species
is encoded by: hsa:4714
has part: Q7GXY9
has part: P19404
has part: O43674
constant: false
has part: O95169
initial concentration: NaN
is encoded by: hsa:4698
has part: C9JT23
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
has part: Q6FG42
is encoded by: hsa:4539
has part: E5KNH5
is encoded by: hsa:4540
boundary condition: true
is encoded by: hsa:4724
is encoded by: hsa:4536
is encoded by: hsa:4694
is encoded by: hsa:55967
is encoded by: hsa:4708
is encoded by: hsa:4715
is encoded by: hsa:4705
is encoded by: hsa:4697
has part: O00483
has part: P03905
is encoded by: hsa:126328
is encoded by: hsa:4729
has part: O43678
has part: Q6IBA0
has part: O43181
has part: O75489
has part: O75438
has part: O75251

metaR S6T12g
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
type: Reaction
product: MODEL1310110014#
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
reactant: MODEL1310110014#

metaM nadp c
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
initial concentration: 1.0
is: CHEBI:58349
is: HMDB00217
type: Species
is: C00006
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate

metaR P4502C94
modifier: MODEL1310110014#
reversible: false
product: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
is: SBO:0000176
reactant: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (1559.1) or (1557.1) SUBSYSTEM: Limonene and pinene degradation EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:11950794,PMID:11996015 NOTES:assumed to take place on outer membrane NJ
is version of: http://identifiers.org/ec-code/1.14.13.48
is described by: ECO:0000269
name: cytochrome P450 2C9

metaM dgtp c
name: dGTP
is: C00286
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
has only substance units: false
is: SBO:0000247
is: HMDB01440
is: CHEBI:16497
constant: false

metaR EX aprgstrn LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 20alpha-Hydroxyprogesterone exchange
type: Reaction

metaR CITt4 4
is: SBO:0000185
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
fast: false
product: MODEL1310110014#
reactant: MODEL1310110014#
name: citrate transport via sodium symport
modifier: MODEL1310110014#
is described by: ECO:0000006
kinetic law: MODEL1310110014#
reversible: true
type: Reaction

metaR ADPRDP
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.13
is described by: ECO:0000269
fast: false
reactant: MODEL1310110014#
is: SBO:0000176
kinetic law: MODEL1310110014#
type: Reaction
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (11164.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.13 Confidence Level: 4 AUTHORS: PMID:10567213,PMID:10722730,PMID:12717453 NOTES:
product: MODEL1310110014#
name: ADPribose diphosphatase

http://identifiers.org/biomodels.db/MODEL1310110014#_2485c9fc_2da9_4718_bb51_aeea08591f1f
name: CPT1B
has only substance units: false
is encoded by: hsa:1375
constant: false
is: B7Z5T8
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR r1179
product: MODEL1310110014#
type: Reaction
reversible: false
name: EC:3.1.1.13
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false

metaM ksii core4 pre10 g
is: CHEBI:28067
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
constant: false
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 10
initial amount: NaN
is: SBO:0000247

metaM pyr x
is: CHEBI:15361
name: pyruvate
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
constant: false
has only substance units: false
is: HMDB00243
initial concentration: 1.0
is: C00022
boundary condition: false
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3324
is: SBO:0000247

metaR GLCNACASE4ly
is version of: http://identifiers.org/ec-code/3.2.1.50
type: Reaction
kinetic law: MODEL1310110014#
fast: false
name: alpha-N-acetylglucosaminidase, lysosomal
product: MODEL1310110014#
is described by: ECO:0000000
modifier: MODEL1310110014#
reversible: false
reactant: MODEL1310110014#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110014#_66d57ce7_16e4_4278_99c3_393d86065b8f
boundary condition: true
initial amount: NaN
name: ALDH3A2
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: P51648
is encoded by: hsa:224
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_6ad29c01_4bda_4343_8bb8_b4aa31f9134a
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: IDH1
is: O75874
type: Species
constant: false
is encoded by: hsa:3417

metaR RE2079R
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110014#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
type: Reaction
fast: false
product: MODEL1310110014#
name: RE2079
reactant: MODEL1310110014#

metaM HC02202 c
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
name: prostaglandin A1(1-)
is: CHEBI:57398
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
constant: false

metaR SBTR
reversible: false
type: Reaction
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.21
is version of: http://identifiers.org/ec-code/1.1.1.2
name: D-sorbitol reductase
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000269
reactant: MODEL1310110014#
fast: false
is: SBO:0000176

metaM hdcecrn m
has only substance units: false
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
initial concentration: 1.0
is: SBO:0000247
is: HMDB00222
name: Hexadecenoyl carnitine
boundary condition: false

metaR SPHINGStl
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however sphingosine manages to get in different compartments of cells. NOT presumed to be flip-flop. NJ
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110014#
product: MODEL1310110014#
name: sphingosine intracellular transport

metaM dgtp e
is: SBO:0000247
constant: false
is: HMDB01440
has only substance units: false
name: dGTP
is: CHEBI:16497
initial amount: NaN
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110014#_ed1734b2_04a2_4d60_bef3_c72fe3a0ac8f
name: HPRT1
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is: P00492
is encoded by: hsa:3251
has only substance units: false
boundary condition: true
initial amount: NaN

metaR FRDPtcr
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
fast: false
is described by: ECO:0000134
reversible: true

metaM oaa x
type: Species
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
is: C00036
is: HMDB00223
is: CHEBI:16452
name: Oxaloacetate

metaR FACOAL150
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
reactant: MODEL1310110014#
fast: false
product: MODEL1310110014#
modifier: MODEL1310110014#
reversible: true
name: fatty-acid--CoA ligase

metaR TRDR
is described by: ECO:0000269
is: SBO:0000176
name: thioredoxin reductase (NADPH)
is version of: http://identifiers.org/ec-code/1.8.1.9
modifier: MODEL1310110014#
reversible: false
kinetic law: MODEL1310110014#
type: Reaction
fast: false
reactant: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:

metaM lys L e
is: HMDB00182
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
type: Species
name: L-lysinium(1+)
constant: false
initial amount: NaN
is: CHEBI:32551
boundary condition: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_bb707bc3_8baa_4681_9702_080df6c79d64
is: SBO:0000252
has only substance units: false
name: RDH14
is encoded by: hsa:57665
initial amount: NaN
type: Species
is: Q9HBH5
constant: false
boundary condition: true
initial concentration: NaN

metaR CITt4 2
type: Reaction
is: SBO:0000185
product: MODEL1310110014#
fast: false
name: citrate transport via sodium symport
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
modifier: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_6edb171b_fa9e_4bbb_9d2f_97f7c897977c
name: AK4
constant: false
is: SBO:0000252
is encoded by: hsa:205
is: P27144
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false

metaM ksi deg14 l
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
is: SBO:0000247
constant: false
type: Species
is: CHEBI:12936
initial concentration: 1.0
name: keratan sulfate I, degradation product 14
has only substance units: false
boundary condition: false
is: HMDB00143
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_759d8e45_ef24_443b_88ba_d3ec051981a9
type: Species
name: PIGF
has only substance units: false
is encoded by: hsa:5281
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q6IB04
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_7ebd8c25_4844_4652_b977_5f1676a3a24a
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is: P21439
is encoded by: hsa:5244
initial concentration: NaN
name: ABCB4
constant: false
type: Species

metaM thcrm hs g
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:24636
type: Species
name: trihexosyl ceramide
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0

metaM gln L c
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: L-glutamine
is: CHEBI:18050
constant: false
initial concentration: 1.0
is: HMDB00641
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
boundary condition: false
type: Species

metaM 3dsphgn c
is: SBO:0000247
is: HMDB01480
constant: false
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
initial amount: NaN
initial concentration: 1.0
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
is: CHEBI:58299

http://identifiers.org/biomodels.db/MODEL1310110014#_22930215_6b67_4676_9064_566a77c27686
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
constant: false
boundary condition: true
name: DHODH
is encoded by: hsa:1723
is: Q02127
is: SBO:0000252

metaR DNDPt14m
kinetic law: MODEL1310110014#
name: dUDP transport via dTDP antiport
type: Reaction
modifier: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
is: SBO:0000185
reversible: false
reactant: MODEL1310110014#

metaM gthox m
initial amount: NaN
initial concentration: 1.0
is: HMDB03337
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
boundary condition: false
is: CHEBI:58297
has only substance units: false
is: SBO:0000247
constant: false
type: Species

metaM utp e
initial concentration: 1.0
type: Species
name: UTP(4-)
is: SBO:0000247
is: HMDB00285
is: CHEBI:46398
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
constant: false

metaM dttp n
initial concentration: 1.0
is: SBO:0000247
is: HMDB01342
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
name: dttp[n]
notes: FORMULA: CHARGE: 0
constant: false

metaM pydam c
boundary condition: false
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
is: HMDB01431
is: CHEBI:57761
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
constant: false
name: Pyridoxamine
initial concentration: 1.0
is: C00534

metaR FAOXC16080m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
fast: false
is: SBO:0000176
modifier: MODEL1310110014#
type: Reaction
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid

metaM 3aib c
boundary condition: false
is: HMDB02166
type: Species
name: (S)-3-aminoisobutyric acid
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: CHEBI:33094

metaM andrstandn r
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
name: 5alpha-androstane-3,17-dione
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: CHEBI:15994
is: SBO:0000247
is: HMDB00899

metaR CERT2gt
is version of: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000185
name: ceramide transport protein
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
reversible: true
kinetic law: MODEL1310110014#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110014#
modifier: MODEL1310110014#

metaR O2Stx
type: Reaction
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110014#
name: superoxide anion transport via diffusion (peroxisome)
reactant: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
kinetic law: MODEL1310110014#

metaR TTDCPT2
fast: false
name: carnitine transferase
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR LNLNCACPT1
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
name: carnitine O-palmitoyltransferase
type: Reaction
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000269
reactant: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false

metaM prostgd2 c
is: HMDB01403
name: prostaglandin D2(1-)
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57406

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaR MANt1r
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110014#
name: mannose transport (uniport)
reversible: true
reactant: MODEL1310110014#
is: SBO:0000185
modifier: MODEL1310110014#
product: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110014#_ce3717a5_b6ee_482c_b0b8_2476b90ce6cf
name: NDUFB11
is: SBO:0000252
is encoded by: hsa:54539
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: Q9NX14
initial concentration: NaN
boundary condition: true

metaR CYTK9n
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: true
product: MODEL1310110014#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110014#
is described by: ECO:0000269
is: SBO:0000176
name: cytidylate kinase (CMP,dCTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110014#_f3686532_2326_4391_91a0_3b165f1ced75
has only substance units: false
has part: E9KL44
is encoded by: hsa:3032
type: Species
is: SBO:0000297
has part: P55084
is encoded by: hsa:3030
initial concentration: NaN
name: HADHA:HADHB
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_ce3e6934_fb72_4f09_8a1e_d94a671de0d7
type: Species
is encoded by: hsa:3295
boundary condition: true
has only substance units: false
is: E9PB82
initial concentration: NaN
constant: false
name: HSD17B4
initial amount: NaN
is: SBO:0000252

metaM dttp m
is: C00459
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB01342
name: dTTP
is: CHEBI:37568
boundary condition: false
constant: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_37c6aef5_6f3b_4592_8849_8653c62bc7d5
is encoded by: hsa:53354
type: Species
name: PANK1
is: Q8TE04
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR LEUKTRA4t
name: leukotriene A4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
is: SBO:0000185
type: Reaction
fast: false
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110014#
product: MODEL1310110014#
kinetic law: MODEL1310110014#

metaR NDP8ex
is version of: http://identifiers.org/ec-code/3.6.1.6
product: MODEL1310110014#
modifier: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
is: SBO:0000176
name: nucleoside-diphosphatase (UTP), extracellular
reversible: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#

metaR r1380
is: SBO:0000176
kinetic law: MODEL1310110014#
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_36f1fe02_44d8_409e_9a1d_2b2d2284def5
type: Species
is encoded by: hsa:375056
constant: false
is: SBO:0000252
is: Q5JRA6
has only substance units: false
boundary condition: true
name: MIA3
initial concentration: NaN
initial amount: NaN

metaM gln L e
boundary condition: false
is: CHEBI:18050
constant: false
is: HMDB00641
has only substance units: false
name: L-glutamine
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_9cd60e77_b837_4bc1_b165_55acc281750f
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
name: FOLR1
is encoded by: hsa:2348
constant: false
has only substance units: false

metaR LNLNCACPT2
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
product: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000176
reversible: false
name: carnitine transferase
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110014#

metaR PTDCACRNCPT2
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
kinetic law: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
modifier: MODEL1310110014#
product: MODEL1310110014#
name: pentadecanoate transport into the mitochondria
reactant: MODEL1310110014#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110014#_bedf4e59_ee3c_4e8a_80f9_0b2da3d8154a
is encoded by: hsa:6120
type: Species
initial concentration: NaN
name: RPE
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q96AT9
boundary condition: true

metaM utp c
initial concentration: 1.0
name: UTP
type: Species
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: C00075
has only substance units: false
is: SBO:0000247
is: HMDB00285
is: CHEBI:46398
boundary condition: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_ee5a3333_98c0_4777_81de_e08f4f6d64bb
type: Species
has only substance units: false
is: Q96AS2
is encoded by: hsa:427
initial amount: NaN
is: SBO:0000252
name: ASAH1
constant: false
initial concentration: NaN
boundary condition: true

metaM 3aib e
has only substance units: false
initial amount: NaN
is: HMDB02166
name: (S)-3-aminoisobutyric acid
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: CHEBI:33094

metaR r1381
reactant: MODEL1310110014#
reversible: true
is described by: ECO:0000000
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
kinetic law: MODEL1310110014#
fast: false
type: Reaction
product: MODEL1310110014#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:

metaM 3tetd7ecoacrn c
boundary condition: false
is: HMDB02014
name: 3-hydroxy tetradecenoyl-7-carnitine
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C21H39NO5 CHARGE: 0
type: Species
initial amount: NaN
is: SBO:0000247

metaM HC01376 m
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:28692
initial amount: NaN
name: S-(2-Methylbutanoyl)-dihydrolipoamide
has only substance units: false
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118

metaM phyt x
name: phytanate
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:37257
type: Species
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
is: HMDB00801
boundary condition: false
constant: false
has only substance units: false

metaR PTDCACRNCPT1
reversible: false
reactant: MODEL1310110014#
fast: false
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
name: carnitine fatty-acyl transferase
notes: GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000269

metaM o2 x
is: C00007
type: Species
initial amount: NaN
is: HMDB01377
initial concentration: 1.0
has only substance units: false
is: CHEBI:15379
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
constant: false
is: SBO:0000247

metaM dd5ecoa m
is: SBO:0000247
is: HMDB13028
boundary condition: false
is: C01942
has only substance units: false
initial amount: NaN
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species
name: 5-dodecenoylcoa
constant: false

metaR r0830
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.16

metaM gluala e
name: 5-L-Glutamyl-L-alanine
has only substance units: false
initial amount: NaN
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
type: Species
is: http://identifiers.org/pubchem.compound/6503
is: SBO:0000247
boundary condition: false
is: HMDB06248
is: C03740
constant: false
initial concentration: 1.0

metaM g6p c
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
constant: false
name: D-Glucose 6-phosphate
is: CHEBI:61548
has only substance units: false
initial amount: NaN
is: HMDB01401
type: Species
boundary condition: false
is: C00092
is: SBO:0000247

metaR EX limnen LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Limonene exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_d40e6f67_6230_41e7_b1ad_3f1b9fb78f8f
constant: false
type: Species
is encoded by: hsa:2592
is: B2RAT6
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: GALT
initial amount: NaN
has only substance units: false

metaR r0634
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
product: MODEL1310110014#
is: SBO:0000176
fast: false
modifier: MODEL1310110014#
is described by: ECO:0000000
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.1
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16

metaM hs deg17 l
is: CHEBI:21338
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
initial amount: NaN
type: Species
has only substance units: false
is: HMDB02704
is: SBO:0000247
constant: false
name: heparan sulfate, degradation product 17

http://identifiers.org/biomodels.db/MODEL1310110014#_4e499a86_201a_43c9_bd13_944d374dc1c6
has only substance units: false
name: _AI539321_1_c
is: SBO:0000252
is encoded by: hsa:AI539321
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_f0f1d862_3c44_48be_acfb_30998d2803a0
name: LDHD
boundary condition: true
initial amount: NaN
is encoded by: hsa:197257
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false

metaR LNLNCGCRNt
name: transport into the mitochondria (carnitine)
product: MODEL1310110014#
fast: false
reversible: false
is: SBO:0000185
modifier: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110014#_09ebe0a2_2f21_4d82_85d7_ec7dde70359c
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
name: GSTZ1
initial concentration: NaN
is encoded by: hsa:2954
constant: false

metaM hdcecrn c
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
boundary condition: false
name: Hexadecenoyl carnitine
is: HMDB00222

http://identifiers.org/biomodels.db/MODEL1310110014#_1789301f_c186_4adc_a8ca_a6782723ca29
initial amount: NaN
is: Q9BZQ4
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:23057
name: NMNAT2

http://identifiers.org/biomodels.db/MODEL1310110014#_7c49ec38_fa2d_4b10_be8d_3f7cc7fa12d2
initial concentration: NaN
is: SBO:0000252
is: Q308M7
is encoded by: hsa:5169
type: Species
constant: false
has only substance units: false
name: ENPP3
initial amount: NaN
boundary condition: true

metaR ALAt2r
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
modifier: MODEL1310110014#
is described by: ECO:0000304
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
name: L-alanine reversible transport via proton symport

metaR RE2658R
is described by: ECO:0000000
kinetic law: MODEL1310110014#
product: MODEL1310110014#
name: RE2658
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
type: Reaction
reactant: MODEL1310110014#
is: SBO:0000176
reversible: true
fast: false

metaR r0633
reversible: true
reactant: MODEL1310110014#
fast: false
product: MODEL1310110014#
is: SBO:0000176
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is version of: http://identifiers.org/ec-code/2.7.7.3
modifier: MODEL1310110014#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:

metaM 3tetd7ecoacrn e
has only substance units: false
name: 3-hydroxy tetradecenoyl-7-carnitine
is: SBO:0000247
is: HMDB02014
notes: FORMULA: C21H39NO5 CHARGE: 0
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false

metaR ELAIDCRNt
is: SBO:0000185
reactant: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110014#
reversible: false
kinetic law: MODEL1310110014#
name: transport into the mitochondria (carnitine)
is described by: ECO:0000000
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_4d8a2ed5_0aec_442a_9559_638582930534
has only substance units: false
name: ADSL
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:158
boundary condition: true

metaR TYRCBOX
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.28
type: Reaction
kinetic law: MODEL1310110014#
is described by: ECO:0000134
name: L-Tyrosine carboxy-lyase
is: SBO:0000176
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
modifier: MODEL1310110014#
reactant: MODEL1310110014#
fast: false

metaM formcoa x
name: formyl-CoA(4-)
initial concentration: 1.0
is: HMDB03419
has only substance units: false
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
type: Species
boundary condition: false
is: CHEBI:57376
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_d15973c6_39b9_4a2b_8453_fd855579650d
type: Species
boundary condition: true
name: ADCY6
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is: O43306
is encoded by: hsa:112

metaM spc hs e
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
is: http://identifiers.org/pubchem.compound/5311445
initial concentration: 1.0
name: sphingosylphosphorylcholine
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false

metaM tdcrn e
boundary condition: false
initial concentration: 1.0
type: Species
name: myristoyl carnitine
initial amount: NaN
notes: FORMULA: C21H41NO4 CHARGE: 0
has only substance units: false
is: SBO:0000247
is: HMDB05066
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_9cabfbee_ec9e_4b6d_ac3d_976f583302c8
is: Q9H477
type: Species
name: RBKS
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:64080
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR TRIODTHYt2
kinetic law: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is: SBO:0000185
product: MODEL1310110014#
fast: false
name: T3 transport via facilitated diffusion
reversible: true
is described by: ECO:0000269

metaR NODe
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110014#
name: NODe
product: MODEL1310110014#
kinetic law: MODEL1310110014#

metaM m7masnB r
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: C05881
type: Species
has only substance units: false
notes: FORMULA: C64H107N2O50X CHARGE: 0
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_a017039f_cc62_4338_bd6b_a97ab393f3a6
initial amount: NaN
is encoded by: hsa:115
name: ADCY9
constant: false
is: SBO:0000252
is: O60503
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species

metaM tettet6 c
is: SBO:0000247
name: tetracosatetraenoic acid n-6
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
is: HMDB06246
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
type: Species
initial amount: NaN

metaM pyr m
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
initial amount: NaN
name: pyruvate
has only substance units: false
initial concentration: 1.0
is: HMDB00243
is: http://identifiers.org/pubchem.compound/3324
is: CHEBI:15361
boundary condition: false
constant: false
is: SBO:0000247
is: C00022
type: Species

metaR CYTDK2m
reversible: false
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
is: SBO:0000176
name: cytidine kinase (ATP), mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
fast: false
is described by: ECO:0000000

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaR r1497
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:11819755,PMID:17404808,PMID:6384004 NOTES:
type: Reaction
kinetic law: MODEL1310110014#
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
product: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
fast: false

metaR r1384
is: SBO:0000176
reversible: true
product: MODEL1310110014#
is described by: ECO:0000000
reactant: MODEL1310110014#
name: Guanosine aminohydrolase EC:3.5.4.15
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
kinetic law: MODEL1310110014#
fast: false
type: Reaction

metaR FACOAL246 1
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000176
modifier: MODEL1310110014#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110014#
fast: false
name: fatty-acid--CoA ligase

metaR CITRtm
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
product: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
name: citrulline mitochondrial transport via proton antiport
is: SBO:0000185
reversible: true
reactant: MODEL1310110014#
modifier: MODEL1310110014#

metaR ARACHDt2
reactant: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
kinetic law: MODEL1310110014#
name: fatty acid transport via diffusion
fast: false
reversible: true
product: MODEL1310110014#
is: SBO:0000185

metaR OXAHCOtex
kinetic law: MODEL1310110014#
name: oxalate transport via bicarbonate countertransport
reactant: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000304
is: SBO:0000185
reversible: false
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (1836.1) or (10861.1) or (10861.3) or (10861.2) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
fast: false
type: Reaction

metaM tddedicoa m
boundary condition: false
is: http://identifiers.org/pubchem.compound/5280771
type: Species
is: SBO:0000247
constant: false
name: trans3,6dodecadienoylcoa
initial concentration: 1.0
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
has only substance units: false
initial amount: NaN

metaR TTDCPT1
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1374.1) or (1375.2) or (126129.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110014#
is: SBO:0000176
reversible: false
reactant: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine O-palmitoyltransferase
fast: false
modifier: MODEL1310110014#
type: Reaction

metaM ksi deg35 l
is: SBO:0000247
name: keratan sulfate I, degradation product 35
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
constant: false
is: HMDB00143
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:12936
initial concentration: 1.0

metaR r0409
modifier: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275 NOTES:
reversible: true
kinetic law: MODEL1310110014#
type: Reaction
name: UTP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.10
product: MODEL1310110014#

metaM ksii core2 deg2 l
is: HMDB00143
has only substance units: false
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 2
initial amount: NaN
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110014#_a00e9808_b020_461f_96d0_e24e02ec5f5a
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is: P23919
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: DTYMK
is encoded by: hsa:1841

http://identifiers.org/biomodels.db/MODEL1310110014#_1c507479_e2fc_4347_922f_5f363f6c2f4d
type: Species
has only substance units: false
is encoded by: hsa:2710
boundary condition: true
initial amount: NaN
is: B4DH54
is: SBO:0000252
constant: false
initial concentration: NaN
name: GK

http://identifiers.org/biomodels.db/MODEL1310110014#_f8049484_e95a_4500_b1ed_d25b26b71105
boundary condition: true
name: NDUFC1
is encoded by: hsa:4717
is: O43677
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species

metaR GLUNm
type: Reaction
reactant: MODEL1310110014#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.1.2
reversible: false
modifier: MODEL1310110014#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (2744.1) or (27165.2) or (27165.1) SUBSYSTEM: Glutamate metabolism EC Number: 3.5.1.2 Confidence Level: 4 AUTHORS: PMID:10719215,PMID:12579526 NOTES:
product: MODEL1310110014#
name: glutaminase (mitochondrial)

metaM lys L n
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00182
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: CHEBI:32551
initial concentration: 1.0
constant: false
type: Species
name: L-lysinium(1+)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_09979ec6_7b7c_4c65_ab1e_8a4599371264
name: ADCY10
has only substance units: false
boundary condition: true
is encoded by: hsa:55811
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is: F5GWS5
initial concentration: NaN

metaR FAOXC181C161m
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C16:1)m
type: Reaction

metaM ksi deg6 l
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
name: keratan sulfate I, degradation product 6
is: CHEBI:12936
is: HMDB00143
type: Species
initial concentration: 1.0
constant: false

metaR ADNtm
product: MODEL1310110014#
reactant: MODEL1310110014#
modifier: MODEL1310110014#
reversible: true
fast: false
name: adenosine facilated transport in mitochondria
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_a2ca8da1_ceee_4790_acc0_c6a97bb61967
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P16930
is encoded by: hsa:2184
is: SBO:0000252
boundary condition: true
constant: false
name: FAH
type: Species

metaM m7mpdol L r
is: CHEBI:37636
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial concentration: 1.0
notes: FORMULA: C1720H2828N20O570P20 CHARGE: -20
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false

metaR C226CRNt
reactant: MODEL1310110014#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110014#
name: C226 transport into the mitochondria
product: MODEL1310110014#
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV

metaR FAOXC16BRx
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16br)x
type: Reaction

metaM HC01223 m
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
is: CHEBI:57340
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
type: Species
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)

metaM tdcrn c
name: myristoyl carnitine
notes: FORMULA: C21H41NO4 CHARGE: 0
initial concentration: 1.0
is: HMDB05066
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false

metaM dxtrn c
initial amount: NaN
initial concentration: 1.0
constant: false
name: phosphorylase-limit dextrin (glycogenin-1,6{4[1,4-Glc], 4[1,4-Glc]})
has only substance units: false
notes: FORMULA: C48H81O41X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02135
boundary condition: false
is: HMDB00127
is: CHEBI:15748
is: SBO:0000247
type: Species

metaR r0630
kinetic law: MODEL1310110014#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.1
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
type: Reaction
reversible: true
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.2
is described by: ECO:0000000
product: MODEL1310110014#

metaR RE0958E
is version of: http://identifiers.org/ec-code/3.2.1.1
reversible: true
reactant: MODEL1310110014#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.17
name: RE0958
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000000
product: MODEL1310110014#
fast: false

metaR r0408
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
is version of: http://identifiers.org/ec-code/1.4.3.5
kinetic law: MODEL1310110014#
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
modifier: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_e3cdee2a_30bc_4ee1_91be_e014c1e373bb
type: Species
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
name: ENTPD3
is: SBO:0000252
is encoded by: hsa:956
initial amount: NaN
is: O75355

metaM lys L m
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: CHEBI:32551
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00182
name: L-lysinium(1+)
boundary condition: false
constant: false
type: Species

metaR CYTDtm
name: cytidine facilated transport in mitochondria
reversible: true
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
reactant: MODEL1310110014#
type: Reaction
fast: false
product: MODEL1310110014#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110014#

metaM tettet6 e
is: HMDB06246
name: tetracosatetraenoic acid n-6
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_61930bf9_46a0_4cab_8de1_af216b3159e0
type: Species
is encoded by: hsa:BE966236
has only substance units: false
boundary condition: true
initial concentration: NaN
name: _BE966236_1_m
constant: false
initial amount: NaN
is: SBO:0000252

metaR 4MOPte
kinetic law: MODEL1310110014#
is: SBO:0000185
name: Transport of 4-methyl-2-oxopentanoate
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
product: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_4d50d3f6_4da5_42fb_a721_180fa186e882
has only substance units: false
is: O15245
boundary condition: true
name: SLC22A1
constant: false
initial amount: NaN
is encoded by: hsa:6580
is: SBO:0000252
initial concentration: NaN
type: Species

metaR r1291
is: SBO:0000185
name: Postulated transport reaction
type: Reaction
reactant: MODEL1310110014#
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110014#

metaM gthox c
name: Oxidized glutathione
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
initial amount: NaN
type: Species
constant: false
is: CHEBI:58297
initial concentration: 1.0
is: C00127
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB03337

metaM ksi pre1 g
is: HMDB00175
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:58053
has only substance units: false
type: Species
is: C00130
name: keratan sulfate I biosynthesis, precursor 1
initial concentration: 1.0
notes: FORMULA: C79H129N5O57X CHARGE: -1
constant: false

metaM vacc c
is: C08367
constant: false
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
is: SBO:0000247
name: trans-vaccenate
initial amount: NaN
is: CHEBI:30828

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_bf8b9e60_fe33_4730_a433_9e3e79da74ae
initial concentration: NaN
has only substance units: false
name: PDE11A
is encoded by: hsa:50940
boundary condition: true
initial amount: NaN
is: Q9HCR9
type: Species
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_7bc5ec4d_00b3_4dac_abee_39945d0660dd
constant: false
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:55825
name: PECR
boundary condition: true
is: SBO:0000252
is: Q9BY49

metaM gtp n
name: GTP(4-)
initial amount: NaN
is: HMDB01273
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
constant: false
type: Species
is: CHEBI:37565
has only substance units: false
is: SBO:0000247

metaR It
product: MODEL1310110014#
modifier: MODEL1310110014#
type: Reaction
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
reactant: MODEL1310110014#
is: SBO:0000185
name: Iodide uniport
is described by: ECO:0000269
fast: false
reversible: true
kinetic law: MODEL1310110014#

metaR MG3er
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
reversible: false
reactant: MODEL1310110014#
product: MODEL1310110014#
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum

metaM o2 r
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: C00007
is: HMDB01377
is: CHEBI:15379
has only substance units: false
constant: false
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
type: Species

metaM ksi e
is: HMDB00211
type: Species
name: keratan sulfate I
is: SBO:0000247
initial amount: NaN
is: CHEBI:17268
constant: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaM HC02213 e
has only substance units: false
name: prostaglandin-e3
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28031
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439

http://identifiers.org/biomodels.db/MODEL1310110014#_5b4b4743_e2ae_49a1_86a3_cffed77eedf7
is: SBO:0000252
is: E9PE48
boundary condition: true
constant: false
is encoded by: hsa:435
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: ASL
type: Species

metaR RE1901R
is described by: ECO:0000000
product: MODEL1310110014#
name: RE1901
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799,PMID:11279029 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000176

metaM 4mop c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
has only substance units: false
type: Species
constant: false
name: 4-methyl-2-oxopentanoate
boundary condition: false
is: SBO:0000247
is: HMDB00695
is: CHEBI:17865

http://identifiers.org/biomodels.db/MODEL1310110014#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_g
initial concentration: 1.0
initial amount: NaN
is: HMDB00304
is: CHEBI:57847
is: SBO:0000247
type: Species
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
name: Type IIIA glycolipid

http://identifiers.org/biomodels.db/MODEL1310110014#_8ef9d2f8_ffa4_4b4b_aa6c_5e1ccafba097
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:11112
constant: false
name: HIBADH
has only substance units: false
is: P31937
boundary condition: true
type: Species

metaR FAOXC12DCc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: formation of dodecanedioyl carnitine
type: Reaction

metaR FAOXC102x
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)x
type: Reaction

metaR EX doco13ac
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

metaM rnam c
has only substance units: false
name: N-Ribosylnicotinamide
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00855
boundary condition: false
constant: false
is: CHEBI:15927
is: SBO:0000247
notes: FORMULA: C11H15N2O5 CHARGE: 1 INCHI: InChI=1S/C11H14N2O5/c12-10(17)6-2-1-3-13(4-6)11-9(16)8(15)7(5-14)18-11/h1-4,7-9,11,14-16H,5H2,(H-,12,17)/p+1/t7-,8-,9-,11-/m1/s1 EHMN_ABBREVIATION: C03150

metaM asn L m
type: Species
has only substance units: false
name: L-asparagine
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00168
is: CHEBI:17196
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148

metaR DOLPMT L
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
name: Dolichyl-phosphate D-mannosyltransferase (liver)
fast: false
reversible: false
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.83
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_89361ebd_cbb8_4a81_a125_f7eeec7c9245
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:954
name: ENTPD2
boundary condition: true
initial concentration: NaN
constant: false
is: Q5SPY7

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

metaM CE1617 r
type: Species
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8-,16-14+ EHMN_ABBREVIATION: CE1617
has only substance units: false
boundary condition: false
is: HMDB01358
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17898
name: 9-cis-retinoate
is: SBO:0000247

metaM dttp e
is: CHEBI:37568
type: Species
is: HMDB01342
name: dTTP(4-)
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR EX pect LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectins
type: Reaction

metaR 5MTHFt2le
reversible: true
product: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
name: 5-methyltetrahydrofolate transport via anion exchange
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134

metaR APOC LYS BTNPm
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110014#
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000000
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
name: proteolysis of apoC-Lys-btn, mitochondrial
type: Reaction

metaM vacc e
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
is: CHEBI:30828
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
name: trans-vaccenate
boundary condition: false

metaR r2120
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110014#
reactant: MODEL1310110014#
modifier: MODEL1310110014#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110014#

metaM HC02213 c
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:28031
name: prostaglandin-e3
type: Species
initial concentration: 1.0

metaR CEPTE
notes: GENE_ASSOCIATION: (10390.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110014#
fast: false
name: ethanolamine phosphotransferase
is version of: http://identifiers.org/ec-code/2.7.8.2
product: MODEL1310110014#
modifier: MODEL1310110014#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110014#
is: SBO:0000176
reversible: false

metaM 4mop e
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00695
boundary condition: false
name: 4-methyl-2-oxopentanoate
is: CHEBI:17865
initial amount: NaN

metaM ksi g
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I
boundary condition: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: HMDB03418
is: CHEBI:16443
has only substance units: false
type: Species
is: SBO:0000247
constant: false

metaR C16DCc
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexadecanedioylcarnitine
type: Reaction

metaR SERHL
fast: false
product: MODEL1310110014#
kinetic law: MODEL1310110014#
is described by: ECO:0000269
modifier: MODEL1310110014#
type: Reaction
name: L-Serine hydro-lyase
is: SBO:0000176
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/4.3.1.17
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:2674117 NOTES:MM
reversible: false

metaR S4TASE2ly
is: SBO:0000176
type: Reaction
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.6.12
modifier: MODEL1310110014#
is described by: ECO:0000000
name: N-acetylgalactosamine-4-sulfatase, lysosomal
fast: false
kinetic law: MODEL1310110014#
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
reversible: true

metaM nadp m
type: Species
name: Nicotinamide adenine dinucleotide phosphate
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: C00006
is: CHEBI:58349
is: HMDB00217
initial amount: NaN

metaM spc hs c
initial concentration: 1.0
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5311445
boundary condition: false
name: sphingosylphosphorylcholine
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_db475c85_2850_4fbe_9b83_5f898488f43e
is encoded by: hsa:4247
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is: Q10469
boundary condition: true
name: MGAT2

http://identifiers.org/biomodels.db/MODEL1310110014#_c188bf70_c618_4217_8e94_1f1e72e4ddcc
name: INPP5E
constant: false
boundary condition: true
is: Q9NRR6
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:56623
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110014#_d57ee6d7_68ac_4b34_9a24_749aba3948fb
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:AI440329
name: _AI440329_1_r
constant: false
boundary condition: true
initial concentration: NaN

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaR DLNLCGCPT2
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
is: SBO:0000176
modifier: MODEL1310110014#
name: carnitine transferase
fast: false
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.21

metaM 13 cis retn n
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: D00348
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB06219
type: Species
name: 13-cis-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
is: http://identifiers.org/pubchem.compound/7847414

metaR r1292
reversible: true
type: Reaction
name: Postulated transport reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
product: MODEL1310110014#

metaR LAPCOAl
reversible: false
notes: GENE_ASSOCIATION: (53.1) SUBSYSTEM: CoA catabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:11923312,PMID:11994049 NOTES:IT. human enzymes overexpressed on E.coli, Pig Liver
kinetic law: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000304
fast: false
reactant: MODEL1310110014#
name: lysosomal acid phosphorylase (CoA)
is version of: http://identifiers.org/ec-code/3.1.3.2
modifier: MODEL1310110014#
is: SBO:0000176
type: Reaction

metaM trdox m
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: Oxidized thioredoxin
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
is: CHEBI:18191
has only substance units: false
type: Species
boundary condition: false

metaM o2 n
type: Species
has only substance units: false
is: CHEBI:15379
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
name: dioxygen
is: HMDB01377
constant: false

metaM gtp m
is: C00044
type: Species
has only substance units: false
constant: false
is: SBO:0000247
name: GTP
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: CHEBI:37565
is: HMDB01273
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_63b35446_c2c8_42b5_9d35_31415d127894
name: SLC5A3
constant: false
is: P53794
initial concentration: NaN
is encoded by: hsa:6526
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_5a173b28_2987_41dc_bb7c_2965b799c60c
constant: false
has only substance units: false
is: SBO:0000252
name: TUSC3
is encoded by: hsa:7991
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true

metaR FADtru
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
reversible: false
type: Reaction
name: FAD transporter, endoplasmic reticulum
product: MODEL1310110014#

metaR q10h2tc
is: SBO:0000185
reactant: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
name: transport of ubiquinol into cytosol
fast: false
reversible: true
product: MODEL1310110014#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110014#_6afdfef9_5ebd_42ca_a589_5409333481f9
is: SBO:0000252
name: LEFTY1
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:10637
boundary condition: true
has only substance units: false
is: O75610

http://identifiers.org/biomodels.db/MODEL1310110014#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_c
boundary condition: false
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
is: CHEBI:18287
is: HMDB00174
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
initial amount: NaN
constant: false
initial concentration: 1.0

metaM pro L m
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: L-proline
type: Species
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00162
is: CHEBI:17203

http://identifiers.org/biomodels.db/MODEL1310110014#_2b9207b8_e2b5_40f3_9a0d_54b2aeacbcb6
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4952
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
name: OCRL

metaR SPHK21c
is: SBO:0000176
is described by: ECO:0000269
fast: false
reactant: MODEL1310110014#
reversible: false
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
name: sphingosine kinase 2
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.7.1.91
product: MODEL1310110014#

metaR CEPTC
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.2
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (10390.1) or (56994.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110014#
name: choline phosphotransferase
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110014#_0840d8d4_72fd_4748_ac8c_363057ff0cf3
name: CA9
boundary condition: true
is: Q16790
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:768
type: Species

metaR r2122
modifier: MODEL1310110014#
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110014#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110014#
reversible: true
is: SBO:0000185
reactant: MODEL1310110014#

metaM o2 m
is: C00007
constant: false
name: O2
boundary condition: false
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB01377
initial amount: NaN
is: CHEBI:15379

metaR AG13T9g
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
reversible: false
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction

metaR DLNLCGCPT1
reversible: false
is described by: ECO:0000000
product: MODEL1310110014#
kinetic law: MODEL1310110014#
fast: false
type: Reaction
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110014#
name: carnitine O-palmitoyltransferase

metaM 13 cis retn r
is: http://identifiers.org/pubchem.compound/7847414
initial concentration: 1.0
is: HMDB06219
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
name: 13-cis-retinoate
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: D00348
constant: false
initial amount: NaN

metaM CE4791 x
has only substance units: false
name: 3(S)-hydroxy-dihomo-gama-linolenoyl-CoA
notes: FORMULA: C41H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C41H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29(49)24-32(51)70-23-22-43-31(50)20-21-44-39(54)36(53)41(2,3)26-63-69(60,61)66-68(58,59)62-25-30-35(65-67(55,56)57)34(52)40(64-30)48-28-47-33-37(42)45-27-46-38(33)48/h8-9,11-12,14-15,27-30,34-36,40,49,52-53H,4-7,10,13,16-26H2,1-3H3,(H,43,50)(H,44,54)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/b9-8-,12-11-,15-14-/t29-,30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4791
boundary condition: false
is: CHEBI:57923
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0

metaR F6Tg
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
is: SBO:0000176
fast: false
reversible: false
product: MODEL1310110014#
type: Reaction
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/2.4.1.68
name: glycoprotein 6-alpha-L-fucosyltransferase
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110014#_aa0b499a_7792_45e9_a8ef_110130a9a6ca
initial amount: NaN
constant: false
is encoded by: hsa:T83654
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
name: _T83654_1_c

http://identifiers.org/biomodels.db/MODEL1310110014#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_c
is: CHEBI:15347
is: HMDB01659
name: Type IIIA glycolipid
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR S2L2FN2M2MASNt
is: SBO:0000185
product: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110014#
reversible: false
name: s2l2fn2m2masn transport, Golgi to extracellular
fast: false
reactant: MODEL1310110014#
type: Reaction
is described by: ECO:0000000

metaR C16DCe
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexadecanedioic acid mono-L-carnitine ester into extra cellular space
type: Reaction

metaR r0629
fast: false
kinetic law: MODEL1310110014#
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.22
is described by: ECO:0000000
type: Reaction
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
modifier: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.4.1
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is: SBO:0000176

metaR r2330
reactant: MODEL1310110014#
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
product: MODEL1310110014#
fast: false
kinetic law: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r2443
is: SBO:0000185
product: MODEL1310110014#
reversible: false
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
is described by: ECO:0000000
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110014#

metaM lys L x
has only substance units: false
is: HMDB00182
initial concentration: 1.0
is: CHEBI:32551
name: L-lysinium(1+)
constant: false
type: Species
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
boundary condition: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_116500a6_213b_4d15_9297_7306e3117806
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10317
name: B3GALT5
is: Q9Y2C3
initial amount: NaN
constant: false

metaR r2121
kinetic law: MODEL1310110014#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110014#
product: MODEL1310110014#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110014#
fast: false

metaR r0821
product: MODEL1310110014#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110014#
reactant: MODEL1310110014#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_02fbcc76_7be0_4572_b303_11e404907183
name: ENTPD8
constant: false
has only substance units: false
is: Q5MY95
initial concentration: NaN
is encoded by: hsa:377841
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110014#_394907d2_3ba6_472d_a6ff_5d723b1f049d
type: Species
boundary condition: true
has only substance units: false
constant: false
name: RDH12
is encoded by: hsa:145226
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q96NR8

metaR UGLCNACtg
type: Reaction
fast: false
is described by: ECO:0000269
modifier: MODEL1310110014#
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
product: MODEL1310110014#
name: UDP-GlcNAc Golgi transport via CMP antiport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_693e49af_2ee8_4265_9baf_cd03138957b1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
name: PIGX
has only substance units: false
constant: false
boundary condition: true
is: Q8TBF5
is encoded by: hsa:54965

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaM n2m2masn g
is: C11530
initial concentration: 1.0
notes: FORMULA: C50H83N4O35X CHARGE: 0
boundary condition: false
initial amount: NaN
type: Species
constant: false
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: SBO:0000247
has only substance units: false

metaM glutcoa m
name: glutaryl-CoA(5-)
is: CHEBI:57378
constant: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB01339

metaR AG13T18g
kinetic law: MODEL1310110014#
reversible: false
type: Reaction
fast: false
product: MODEL1310110014#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110014#
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_5f35ef55_7016_4499_8544_68120e4ccd46
type: Species
is: Q5QPH3
initial amount: NaN
boundary condition: true
name: ACSS2
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:55902

metaM cgly c
name: L-cysteinylglycine
constant: false
boundary condition: false
is: HMDB00078
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
is: CHEBI:4047
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110014#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_e
initial concentration: 1.0
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
is: CHEBI:15824
initial amount: NaN
type: Species
is: HMDB00660
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
is: SBO:0000247
boundary condition: false
is: C00095
constant: false
has only substance units: false

metaR TRPt4
is: SBO:0000185
name: L-tryptophan transport in via sodium symport
product: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
reactant: MODEL1310110014#
modifier: MODEL1310110014#
reversible: false
fast: false

metaR ALDD2xm
product: MODEL1310110014#
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
type: Reaction
kinetic law: MODEL1310110014#
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
fast: false
modifier: MODEL1310110014#
is described by: ECO:0000134
reversible: false

metaM tag hs e
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
has only substance units: false
is: CHEBI:17855
initial concentration: 1.0
type: Species
initial amount: NaN
name: triglyceride
constant: false
is: SBO:0000247
boundary condition: false

metaR r2124
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110014#
kinetic law: MODEL1310110014#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110014#
product: MODEL1310110014#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110014#_fcf2d010_d7b2_42cd_8af2_6d5356c169ba
initial concentration: NaN
name: _H77542_1_c
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:H77542
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_3a459ab7_d92f_4cb2_8a92_af6bd62ef22e
name: CMA1
is: Q4FEB3
constant: false
is: SBO:0000252
is encoded by: hsa:1215
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_f701e706_ec7d_4c42_9816_e4ac958c258c
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:349565
name: NMNAT3
is: Q96T66
constant: false
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true

metaR r0822
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110014#
type: Reaction
reversible: true
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
fast: false
product: MODEL1310110014#

metaM prostgd2 e
is: HMDB01403
is: CHEBI:57406
has only substance units: false
type: Species
constant: false
boundary condition: false
name: prostaglandin D2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaM bamppald c
type: Species
name: beta-Aminopropion aldehyde
is: HMDB01106
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7975
is: C05665
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110014#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_e
is: CHEBI:15347
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB01659
boundary condition: false
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
constant: false
type: Species
initial concentration: 1.0
name: Type IIIA glycolipid

metaM dctp n
boundary condition: false
is: C00458
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB00998
is: CHEBI:16311
is: SBO:0000247
name: dCTP
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
initial amount: NaN
constant: false

metaM gcald c
constant: false
initial concentration: 1.0
is: CHEBI:17071
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
is: HMDB03344
boundary condition: false
name: glycolaldehyde
type: Species

metaR ALAGLYexR
kinetic law: MODEL1310110014#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110014#
reactant: MODEL1310110014#
reversible: true
type: Reaction
name: L-alanine/glycine reversible exchange
fast: false
is: SBO:0000185
product: MODEL1310110014#

metaR r2123
reversible: true
kinetic law: MODEL1310110014#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110014#
modifier: MODEL1310110014#
product: MODEL1310110014#
fast: false

metaR r0627
reversible: true
fast: false
is: SBO:0000176
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
product: MODEL1310110014#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
reactant: MODEL1310110014#
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_ff8137bf_94f3_4274_9c5d_91b3a2afa6ce
boundary condition: true
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is: P15954
is encoded by: hsa:1350
initial concentration: NaN
name: COX7C
initial amount: NaN

metaM cs e deg7 l
initial concentration: 1.0
has only substance units: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
notes: FORMULA: C23H35O27S2 CHARGE: -3
is: CHEBI:15936
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247

metaR PPItm
is described by: ECO:0000134
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
name: diphopshate transporter, mitochondrial
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110014#
fast: false
product: MODEL1310110014#

metaR DNDPt15m
modifier: MODEL1310110014#
name: dUDP transport via dGDP antiport
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
product: MODEL1310110014#
is: SBO:0000185
reactant: MODEL1310110014#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_06b01e47_dae3_402e_9fd3_e26fb20c9ade
is: SBO:0000252
type: Species
has only substance units: false
name: HAS2
constant: false
boundary condition: true
initial amount: NaN
is: Q92819
initial concentration: NaN
is encoded by: hsa:3037

http://identifiers.org/biomodels.db/MODEL1310110014#_2ab9639c_9560_4f04_95ca_4d94b6bf5530
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q6LEN6
name: CHAT
is encoded by: hsa:1103
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false

metaM dctp m
initial amount: NaN
constant: false
is: CHEBI:16311
name: dCTP
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
has only substance units: false
type: Species
is: HMDB00998
boundary condition: false
is: C00458
initial concentration: 1.0
is: SBO:0000247

metaR GALASE12ly
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110014#
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is described by: ECO:0000000
product: MODEL1310110014#
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.1.6.4

http://identifiers.org/biomodels.db/MODEL1310110014#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
is: HMDB00174
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
type: Species
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
is: SBO:0000247
constant: false
is: CHEBI:18287
boundary condition: false

metaM nadp r
initial concentration: 1.0
is: HMDB00217
has only substance units: false
is: SBO:0000247
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:58349
is: C00006
type: Species
name: Nicotinamide adenine dinucleotide phosphate

metaM cgly e
constant: false
is: HMDB00078
initial amount: NaN
name: L-cysteinylglycine
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:4047
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419

metaR LNLNCAt
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110014#
product: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: fatty acid transport via diffusion

metaR r0410
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
type: Reaction
kinetic law: MODEL1310110014#
is described by: ECO:0000000
product: MODEL1310110014#
reversible: true
is: SBO:0000176
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false

metaM pdx5p c
type: Species
boundary condition: false
name: Pyridoxine 5'-phosphate
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C8H10NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00459 EHMN_ABBREVIATION: C00627
initial concentration: 1.0
has only substance units: false
is: CHEBI:58589
is: C00627
is: HMDB01319

metaM ksi deg13 l
notes: FORMULA: C174H280N12O150S8 CHARGE: -8
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00812
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:16953
name: keratan sulfate I, degradation product 13

metaM g6p r
is: CHEBI:61548
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
name: D-Glucose 6-phosphate
is: C00092
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB01401
constant: false
has only substance units: false
boundary condition: false

metaR FMNAT
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110014#
product: MODEL1310110014#
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000134
reversible: false
name: FMN adenylyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.2
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y

metaR FOLt2le
is described by: ECO:0000134
reactant: MODEL1310110014#
is: SBO:0000185
kinetic law: MODEL1310110014#
fast: false
type: Reaction
reversible: true
product: MODEL1310110014#
name: folate transport via anion exchange
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR FAOXC11
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211 1 round of beta ox of branched chain FA from peroxisome NJ
fast: false
is: SBO:0000176
type: Reaction
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000000
reactant: MODEL1310110014#
modifier: MODEL1310110014#
product: MODEL1310110014#
reversible: false
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110014#_7f1de79c_e04b_4812_81ca_d4b7c800b057
is: SBO:0000252
name: GCSH
initial amount: NaN
is: P23434
has only substance units: false
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:2653

http://identifiers.org/biomodels.db/MODEL1310110014#_e4dba91e_46bf_4aad_89df_25086070544c
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is: Q8N0W3
boundary condition: true
is encoded by: hsa:197258
name: FUK

http://identifiers.org/biomodels.db/MODEL1310110014#_15fc755c_f294_4222_9da8_6700e23090cc
constant: false
name: ENTPD1
boundary condition: true
is: Q86VV3
is encoded by: hsa:953
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species

metaR r2126
is: SBO:0000185
reactant: MODEL1310110014#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110014#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_b0ff3d79_ad09_4253_a175_73c6ec9fcc15
boundary condition: true
initial amount: NaN
is: Q6FHI7
is encoded by: hsa:762
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: CA4
type: Species

metaM cspg b e
initial amount: NaN
is: C00106
is: CHEBI:17568
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
boundary condition: false
has only substance units: false
is: HMDB00300
initial concentration: 1.0

metaR r2333
reversible: true
type: Reaction
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110014#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM tag hs c
initial amount: NaN
name: triglyceride
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: CHEBI:17855
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_17c26d13_80a0_416e_96f6_ca34688da1d6
initial concentration: NaN
is: P35573
name: AGL
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:178
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_df35589d_f1d1_427d_aa20_75837ff6625d
is: SBO:0000252
initial amount: NaN
name: _AU149534_1_m
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:AU149534

http://identifiers.org/biomodels.db/MODEL1310110014#_5ea64339_faff_45c5_9798_eedc0a5b7248
is encoded by: hsa:LOC727762
name: _LOC727762_1_m
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species

metaM pro L c
constant: false
is: HMDB00162
is: CHEBI:17203
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: L-proline
initial amount: NaN
type: Species

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaR EX tststerones LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: testosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_dc1bb674_979c_459e_aa37_1516fab5338a
type: Species
initial concentration: NaN
name: CPS1
constant: false
is: Q59HF8
is encoded by: hsa:1373
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM tchola x
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00036
name: taurocholate
is: CHEBI:36257
type: Species
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
initial amount: NaN
constant: false

metaM asn L e
boundary condition: false
is: HMDB00168
is: SBO:0000247
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:17196
initial concentration: 1.0
name: L-asparagine

metaM ksi pre25 g
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
is: CHEBI:58053
is: C00130
is: HMDB00175
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 25
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110014#_999d8b8b_594a_4b31_aa02_8a418db4432a
constant: false
name: CYP1B1
is: SBO:0000252
is encoded by: hsa:1545
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q16678

metaR G14T11g
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110014#
modifier: MODEL1310110014#
reactant: MODEL1310110014#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110014#

metaM aps c
initial amount: NaN
is: CHEBI:58243
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
name: 5'-adenylyl sulfate(2-)
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
type: Species
is: HMDB01003

metaM 4fumacac c
is: CHEBI:18034
constant: false
is: HMDB01268
initial concentration: 1.0
name: 4-fumarylacetoacetate(2-)
initial amount: NaN
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false

metaR EX tethex3 LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosahexaenoic acid, n-3 exchange
type: Reaction

metaR r2125
product: MODEL1310110014#
modifier: MODEL1310110014#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110014#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110014#

metaR PSERT
product: MODEL1310110014#
kinetic law: MODEL1310110014#
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110014#
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.52
is: SBO:0000176
name: phosphoserine transaminase
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:
modifier: MODEL1310110014#

metaR GMPtg
reactant: MODEL1310110014#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
reversible: true
name: GMP transport (Golgi)
type: Reaction
product: MODEL1310110014#
is: SBO:0000185
kinetic law: MODEL1310110014#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110014#_7b601865_cecf_437b_b679_e39af575b2c4
type: Species
name: SLC8A3
has only substance units: false
initial amount: NaN
is: P57103
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6547
constant: false

metaR r2334
kinetic law: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
fast: false

metaR RE3079X
fast: false
reactant: MODEL1310110014#
modifier: MODEL1310110014#
is: SBO:0000176
name: RE3079
product: MODEL1310110014#
type: Reaction
kinetic law: MODEL1310110014#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:11356164 NOTES:IT - fixed proton

metaR RE2998M
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110014#
type: Reaction
product: MODEL1310110014#
fast: false
reversible: false
name: RE2998
modifier: MODEL1310110014#
reactant: MODEL1310110014#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000

metaM 3ohdcoa x
type: Species
boundary condition: false
name: 3-oxopalmitoyl-CoA(4-)
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
is: SBO:0000247
is: CHEBI:57349
is: HMDB06402
constant: false

metaR NADH2 u10m
reversible: false
is: SBO:0000185
product: MODEL1310110014#
fast: false
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
name: NADH dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.6.5.3
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.6.99.3

metaM 2maacoa m
initial concentration: 1.0
is: HMDB01157
initial amount: NaN
boundary condition: false
is: CHEBI:57335
is: SBO:0000247
constant: false
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
name: 2-methylacetoacetyl-CoA(4-)
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110014#_97764c06_c751_4d24_b3e0_4ff315b37001
is encoded by: hsa:6470
is: P34896
has only substance units: false
initial amount: NaN
constant: false
name: SHMT1
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN

metaR CYANtm
product: MODEL1310110014#
type: Reaction
reversible: true
kinetic law: MODEL1310110014#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
name: Cyanide transport via diffusion (mitochondrial)

metaR PPItr
type: Reaction
kinetic law: MODEL1310110014#
fast: false
name: Diphosphate transporter, endoplasmic reticulum
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110014#
reversible: true
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110014#_fa545718_d8c9_4192_a8ad_801a9461c59e
initial concentration: NaN
is: Q96P26
boundary condition: true
constant: false
is encoded by: hsa:93034
type: Species
has only substance units: false
name: NT5C1B
is: SBO:0000252
initial amount: NaN

metaR RE1526M
product: MODEL1310110014#
kinetic law: MODEL1310110014#
name: RE1526
is described by: ECO:0000000
reversible: true
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110014#
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110014#
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:

metaM CE5116 x
constant: false
name: trans-3-cis-8,11,14-eicosatetraenoyl-CoA
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:57923
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,19-20,28-30,34-36,40,51-52H,4-7,10,13,16-18,21-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,20-19+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE5116
has only substance units: false
boundary condition: false
type: Species

metaM prostgd2 r
initial amount: NaN
has only substance units: false
name: prostaglandin D2(1-)
constant: false
type: Species
is: CHEBI:57406
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: SBO:0000247
is: HMDB01403
boundary condition: false
initial concentration: 1.0

metaR r2331
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110014#
reactant: MODEL1310110014#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
fast: false
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_72270da4_5456_4cca_b931_ab5c4440b5f4
is encoded by: hsa:7167
name: TPI1
constant: false
is: Q53HE2
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species

metaR r2128
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110014#
product: MODEL1310110014#
reversible: true
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110014#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110014#

metaR FAS160COA
name: fatty-acyl-CoA synthase (n-C16:0CoA)
modifier: MODEL1310110014#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
fast: false
is: SBO:0000176
reactant: MODEL1310110014#
reversible: false
kinetic law: MODEL1310110014#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110014#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_30655e2d_3183_4822_a635_c135b4334081
is encoded by: hsa:847
initial amount: NaN
type: Species
name: CAT
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: P04040

metaM pro L e
constant: false
is: HMDB00162
is: CHEBI:17203
boundary condition: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: L-proline
type: Species

http://identifiers.org/biomodels.db/MODEL1310110014#_e45ab7d4_caae_496a_8330_a0245ec4e527
initial concentration: NaN
has only substance units: false
is: P28330
is encoded by: hsa:33
name: ACADL
type: Species
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR GALASE9ly
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
reactant: MODEL1310110014#
product: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
kinetic law: MODEL1310110014#
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110014#
is described by: ECO:0000000
is: SBO:0000176
name: beta-galactosidase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110014#
reactant: MODEL1310110014#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110014#_17940089_ac66_44a4_80a7_0a8461043c5a
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: P08237
name: PFKM
type: Species
is encoded by: hsa:5213
initial concentration: NaN
constant: false
has only substance units: false

metaM acngalgbside hs g
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
constant: false
type: Species
name: sialyl galactosylgloboside
is: CHEBI:17115
boundary condition: false
initial amount: NaN
is: HMDB00187
is: SBO:0000247

metaM dece3coa x
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
boundary condition: false
is: SBO:0000247
name: 3-decenoylcoa
constant: false
type: Species
initial amount: NaN

metaM HC01496 m
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
name: 2-Amino-3-oxoadipate
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:28095
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM asn L c
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: HMDB00168
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
name: L-asparagine
is: CHEBI:17196
initial concentration: 1.0
boundary condition: false

metaR MEOHt2
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110014#
reactant: MODEL1310110014#
name: Methanol diffusion
kinetic law: MODEL1310110014#

http://identifiers.org/biomodels.db/MODEL1310110014#_9a2a05eb_88a8_4c65_a7b7_93c259ab84fd
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
name: OGDH
is: B4E3E9
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4967