http://identifiers.org/biomodels.db/MODEL1310110012#_8c3a6dd9_5a0a_402a_8fb9_548dafb46160
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: Q9GZV3
is encoded by: hsa:60482
name: SLC5A7
constant: false
is: SBO:0000252
initial amount: NaN

metaR A MANASEly
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
name: alpha-mannosidase, lysosomal
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.24
fast: false
reversible: false
product: MODEL1310110012#
is: SBO:0000176

metaR r0680
type: Reaction
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000176
product: MODEL1310110012#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
reactant: MODEL1310110012#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.137

metaR NACHEX24ly
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
modifier: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
fast: false
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_9279f130_0f83_499a_83f8_ef1a9fb22fad
has only substance units: false
is: SBO:0000252
is: Q546H9
type: Species
boundary condition: true
is encoded by: hsa:7915
constant: false
initial concentration: NaN
name: ALDH5A1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_4a84af82_9ac8_47f3_9bc8_f333e56240ed
is: SBO:0000252
constant: false
boundary condition: true
name: _AD000092_1_c
is encoded by: hsa:AD000092
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species

metaR GUACYC
is described by: ECO:0000269
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/4.6.1.2
product: MODEL1310110012#
reversible: false
notes: GENE_ASSOCIATION: (2977.1 and 2983.1) or (4882.2) or (2982.1 and 2974.1) or (2986.1) or (4882.1) or (2984.1) or (4881.1) or (2977.1 and 2974.1) or (3000.1) or (2982.1 and 2983.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.2 Confidence Level: 4 AUTHORS: PMID:10449911,PMID:10777682,PMID:11565546,PMID:11851379,PMID:1352257,PMID:14748740,PMID:15371450,PMID:7601467,PMID:7761400,PMID:7777544,PMID:7954658,PMID:8838319,PMID:9097965,PMID:9742212 NOTES:IT
name: guanylate cyclase
is: SBO:0000176
type: Reaction
reactant: MODEL1310110012#

metaM adrncoa m
is: C16170
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205480
name: adrenyl coenzyme A
constant: false

metaR r1631
reversible: true
fast: false
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110012#
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_ef9619d5_f258_4c00_82ab_a63c43c33225
is encoded by: hsa:6715
name: SRD5A1
is: P18405
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_6fc96437_f71d_489e_9a45_ec16a2b131ab
name: NDUFAB1
initial concentration: NaN
is: O14561
boundary condition: true
type: Species
is encoded by: hsa:4706
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_21d608e5_735a_48e3_8d46_f8f3bc7ad819
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1632
name: ECI1
is: P42126
type: Species

metaM anth e
constant: false
name: anthranilate
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:16567
is: HMDB01123

metaM accoa n
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
name: acetyl-CoA(4-)
constant: false
has only substance units: false
type: Species
is: CHEBI:57288
boundary condition: false
initial amount: NaN
is: HMDB01206

metaM ocdca c
type: Species
is: HMDB00827
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:25629
constant: false
name: stearate
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
initial amount: NaN
is: SBO:0000247

metaM dgchol x
name: glycochenodeoxycholate
initial amount: NaN
is: HMDB00637
boundary condition: false
is: CHEBI:36252
has only substance units: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_147f69a1_dedb_47f9_898a_fa018b7803d1
name: _AI469183_1_x
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:AI469183
boundary condition: true

metaR AG13T3g
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
modifier: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
reversible: false
kinetic law: MODEL1310110012#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149

metaR ARACHDt2
product: MODEL1310110012#
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: fatty acid transport via diffusion
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
kinetic law: MODEL1310110012#

metaR SERDGLNexR
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110012#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110012#
name: D-Serine/Glutamine reversible exchange
type: Reaction
is described by: ECO:0000304
product: MODEL1310110012#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_5dd19252_11d9_468c_9daa_061b194af0d3
is: SBO:0000252
is encoded by: hsa:3945
name: LDHB
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P07195
boundary condition: true
type: Species
constant: false

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR IVCRNe
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of isovaleryl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_metaR_ACGALFUCGALACGALFUC12GAL14ACGLCGALGLUSIDEte
reversible: true
type: Reaction
reactant: MODEL1310110012#
name: blood group intracellular transport
kinetic law: MODEL1310110012#
fast: false
is described by: ECO:0000000
product: MODEL1310110012#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ

http://identifiers.org/biomodels.db/MODEL1310110012#_d3a79ccc_50ef_4e47_a66a_cc1ee6441eae
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
name: ACOT2
is: P49753
is encoded by: hsa:10965
constant: false
type: Species

metaR r1630
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110012#
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110012#_ce7f1c77_0256_4ec1_a159_8699e4f7fe48
has only substance units: false
constant: false
initial concentration: NaN
name: PCBD1
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:5092
type: Species
is: P61457

http://identifiers.org/biomodels.db/MODEL1310110012#_0e98862d_876a_4113_8f5d_377a44dbc2a7
initial amount: NaN
is encoded by: hsa:5052
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
name: PRDX1

metaR C141OHc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecenoyl carnitine
type: Reaction

metaR 3SALAASPm
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
kinetic law: MODEL1310110012#
is described by: ECO:0000304
product: MODEL1310110012#
type: Reaction
reversible: true
is: SBO:0000185
fast: false
name: cysteinesulfinate-aspartate mitochondrial shuttle
reactant: MODEL1310110012#

metaM accoa m
initial amount: NaN
is: HMDB01206
is: C00024
is: CHEBI:57288
is: SBO:0000247
boundary condition: false
name: Acetyl-CoA
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false
has only substance units: false
type: Species
initial concentration: 1.0

metaM core6 l
notes: FORMULA: C16H27N2O10X CHARGE: 0
initial amount: NaN
is: HMDB00143
name: Core 6
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:12936
type: Species
constant: false

metaR TAGAT Dt
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
type: Reaction
name: D-tagatose uptake via diffusion
product: MODEL1310110012#
is: SBO:0000185
reactant: MODEL1310110012#
is described by: ECO:0000000
reversible: false

metaR ACNAM9PL
is version of: http://identifiers.org/ec-code/2.5.1.56
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
reactant: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
is: SBO:0000176
fast: false
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#

metaM h2o2 x
is: C00027
is: CHEBI:16240
boundary condition: false
initial amount: NaN
is: HMDB03125
constant: false
name: Hydrogen peroxide
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027

http://identifiers.org/biomodels.db/MODEL1310110012#_e1b69280_c0d6_4490_b8ae_03811afc3440
has only substance units: false
initial amount: NaN
is: O14556
name: GAPDHS
is encoded by: hsa:26330
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_b6d5dbc8_6b5c_4aa6_88fd_622f1cf87deb
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:427
name: ASAH1
is: Q96AS2
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true

metaR 13DAMPPOX
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
type: Reaction
is described by: ECO:0000212
product: MODEL1310110012#
fast: false
reversible: false
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.21
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110012#

metaM cs a deg5 l
is: CHEBI:15936
constant: false
notes: FORMULA: C23H36O24S CHARGE: -2
initial amount: NaN
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaR r1633
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110012#

metaM dtdp m
type: Species
is: HMDB01274
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: dTDP
constant: false
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: C00363
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_2a71dbb1_0064_42f2_a4a4_3b8c2aa3f738
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: P31937
is encoded by: hsa:11112
constant: false
boundary condition: true
name: HIBADH
initial concentration: NaN

metaR GCC2cm
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.1.2.10
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
modifier: MODEL1310110012#
reversible: true
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.4.2
kinetic law: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
product: MODEL1310110012#
name: glycine-cleavage complex (lipoamide), mitochondrial
is described by: ECO:0000269

metaR ESTRADIOLt
fast: false
is described by: ECO:0000000
name: estradiol transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
reversible: true
product: MODEL1310110012#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110012#_74c7bde1_1865_454a_8e32_ebed5a173293
is encoded by: hsa:1120
is: A0PJM6
constant: false
initial amount: NaN
name: CHKB
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM mn l
boundary condition: false
name: beta-1,4-mannose-N-acetylglucosamine
is: SBO:0000247
initial amount: NaN
is: HMDB06535
type: Species
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_e6593a77_62fe_4789_bf41_691cd2a60e5d
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:56474
initial amount: NaN
is: Q9NRF8
boundary condition: true
initial concentration: NaN
name: CTPS2

metaR r1632
modifier: MODEL1310110012#
type: Reaction
fast: false
reactant: MODEL1310110012#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110012#

metaR PLA2 2e
reactant: MODEL1310110012#
is described by: ECO:0000000
name: phospholipase A2
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.4
is: SBO:0000176
modifier: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (5322.1) or (5319.1) or (81579.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (30814.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:10455175,PMID:10681567,PMID:11031251,PMID:11112443,PMID:8300559,PMID:9188469,PMID:9272153,PMID:9886417 NOTES:phosphatidyl choline degradation NJ
fast: false

metaR EX 34dhphe LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxy-L-phenylalanine exchange
type: Reaction

metaR RE3004M
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110012#
name: RE3004
fast: false
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000176

metaM dtdp n
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274
has only substance units: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:58369
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_9fd8fce8_48b2_4e2d_88aa_f80ddfccac2a
name: B3GNT2
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:10678
type: Species

metaR FAOXC16C14m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C14)m
type: Reaction

metaM cs a deg2 l
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:15748
constant: false
has only substance units: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2
is: HMDB00127
notes: FORMULA: C37H55NO38S2 CHARGE: -4
initial amount: NaN
initial concentration: 1.0

metaR GLYCt
reactant: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
kinetic law: MODEL1310110012#
fast: false
reversible: true
name: glycerol transport via channel
product: MODEL1310110012#
type: Reaction

metaR LINKDEG1ly
is: SBO:0000176
name: degradation of proteoglycan linkage region, lysosomal
product: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
reversible: false
type: Reaction
reactant: MODEL1310110012#
is described by: ECO:0000000

metaR CRNt
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
product: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
reversible: true
name: L-carnitine reversible transport
type: Reaction
is: SBO:0000185
modifier: MODEL1310110012#

metaM 3ohdcoa m
initial concentration: 1.0
name: 3-oxopalmitoyl-CoA(4-)
initial amount: NaN
is: HMDB06402
is: CHEBI:57349
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
is: SBO:0000247
has only substance units: false
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_4d797bcc_4124_4d6c_8097_431edac396d3
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: GUCY1B2
initial concentration: NaN
is encoded by: hsa:2974
is: SBO:0000252
boundary condition: true

metaR ADPACDAc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of adipic acid for formation of adipoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_5ebef349_7c71_430e_9867_e3bea1dd97ae
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
name: GALNT14
is: SBO:0000252
is: Q96FL9
initial concentration: NaN
is encoded by: hsa:79623

metaM accoa r
has only substance units: false
is: HMDB01206
initial amount: NaN
is: CHEBI:57288
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
boundary condition: false
type: Species
constant: false
name: acetyl-CoA(4-)

metaM ksii core2 pre3 g
is: HMDB00175
initial concentration: 1.0
notes: FORMULA: C47H76N4O33X CHARGE: -1
is: CHEBI:58053
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 3
constant: false
has only substance units: false
boundary condition: false
is: C00130
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_34b7f95a_76db_4f2f_85cd_a0bfc988a78f
constant: false
type: Species
name: ND1
initial concentration: NaN
initial amount: NaN
is: Q85KV6
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4535

http://identifiers.org/biomodels.db/MODEL1310110012#_192e4d38_a87f_498d_94fd_b879b17552a9
type: Species
boundary condition: true
initial concentration: NaN
name: SLC9A5
is: Q9NSW9
is: SBO:0000252
is encoded by: hsa:6553
has only substance units: false
constant: false
initial amount: NaN

metaR r1635
product: MODEL1310110012#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110012#_067ab61a_5dd8_49b8_87e2_c066b0c13cbb
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
name: BTD
is: P43251
is encoded by: hsa:686

metaM thymd m
is: C00214
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
initial amount: NaN
is: HMDB00273
initial concentration: 1.0
is: SBO:0000247
name: Thymidine
type: Species
is: CHEBI:17748
constant: false
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_93e335c1_c038_4d73_baa5_e85aebd8117f
name: ECHS1
is encoded by: hsa:1892
is: P30084
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR GASNASE2ly
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110012#
name: glycosylasparaginase, lysosomal
is version of: http://identifiers.org/ec-code/3.5.1.26
product: MODEL1310110012#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110012#
reactant: MODEL1310110012#
reversible: false
is described by: ECO:0000000
fast: false

metaM sebacid c
initial concentration: 1.0
is: SBO:0000247
is: HMDB00792
boundary condition: false
notes: FORMULA: C10H16O4 CHARGE: -2
is: C08277
type: Species
name: sebacicacid
initial amount: NaN
constant: false
has only substance units: false

metaR CYTK10n
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
reversible: true
name: cytidylate kinase (CMP,dGTP),nuclear
is: SBO:0000176
fast: false
product: MODEL1310110012#

metaM 2maacoa m
initial amount: NaN
constant: false
initial concentration: 1.0
name: 2-methylacetoacetyl-CoA(4-)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
type: Species
boundary condition: false
is: HMDB01157
is: CHEBI:57335

metaM prgstrn c
initial amount: NaN
is: SBO:0000247
name: progesterone
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: HMDB01830
is: CHEBI:17026
has only substance units: false
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410

metaM mlthf m
is: HMDB01533
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: 5,10-Methylenetetrahydrofolate
is: CHEBI:15636
is: C00143
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
type: Species
initial amount: NaN
is: SBO:0000247
constant: false

metaR r1634
fast: false
type: Reaction
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_e532a527_2cea_4372_9fc9_07ecf438f5f1
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
name: PDE8A
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5151

metaR DMNONCOACRNCPT1
kinetic law: MODEL1310110012#
fast: false
product: MODEL1310110012#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
name: DMNONCOACRNCPT1
reactant: MODEL1310110012#
is described by: ECO:0000000
reversible: true

metaR CSNAT3x
product: MODEL1310110012#
is described by: ECO:0000269
name: carnitine O-aceyltransferase, peroxisomal
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:7654220,PMID:7829107 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.7
fast: false
is: SBO:0000176

metaM tdcoa m
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
constant: false
name: Tetradecanoyl-CoA (n-C14:0CoA)
initial amount: NaN
is: HMDB01521
initial concentration: 1.0
is: C02593
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: CHEBI:57385

metaM CE2435 m
initial amount: NaN
has only substance units: false
is: CHEBI:57795
type: Species
constant: false
initial concentration: 1.0
name: trans,cis-deca-2,4-dienoyl-CoA
is: SBO:0000247
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_c8f170db_3808_4ae9_af5b_0ea494c217f9
constant: false
initial concentration: NaN
is encoded by: hsa:23396
type: Species
boundary condition: true
is: SBO:0000252
name: PIP5K1C
initial amount: NaN
has only substance units: false
is: O60331

metaR AG13T5g
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110012#
type: Reaction
modifier: MODEL1310110012#
fast: false
product: MODEL1310110012#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR r1637
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110012#
type: Reaction
fast: false

metaR r2419
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
product: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110012#
is described by: ECO:0000000
reactant: MODEL1310110012#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110012#_metaR_ACGALFUCGALACGALFUC12GAL14ACGLCGALGLUSIDEtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
name: blood group intracellular transport
reactant: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaM 3ttetddcoacrn c
is: HMDB02014
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
initial amount: NaN
notes: FORMULA: C21H37NO5 CHARGE: 0

metaR ASNGLNNaEx
is: SBO:0000185
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reversible: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110012#
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)
fast: false
modifier: MODEL1310110012#

metaR HIVCRNe
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-isovaleryl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_b3723dc4_e0aa_4836_a826_cf4d221bf1ec
name: FOLR1
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:2348

metaR r0683
is: SBO:0000176
fast: false
product: MODEL1310110012#
modifier: MODEL1310110012#
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110012#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
type: Reaction
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_metaM_fucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
initial amount: NaN
boundary condition: false
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:16094
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
type: Species
is: HMDB00257

metaM HC01405 m
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:28632
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
is: SBO:0000247
name: (S)-Hydroxyoctanoyl-CoA
constant: false
boundary condition: false
initial concentration: 1.0

metaM gmp c
is: C00144
is: CHEBI:58115
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
initial amount: NaN
constant: false
is: HMDB01397
name: GMP
initial concentration: 1.0
boundary condition: false

metaR CYTK6n
name: cytidylate kinase (CMP,CTP),nuclear
is described by: ECO:0000269
kinetic law: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
reactant: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#

metaR ADK3m
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.4.10
reversible: true
type: Reaction
reactant: MODEL1310110012#
name: adentylate kinase (GTP)
is described by: ECO:0000269
fast: false
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_5eb668d2_e520_4dae_8ae7_f1bedd476586
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: ACE
is: B4DKH4
constant: false
has only substance units: false
is encoded by: hsa:1636
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_30de69ba_0ccd_4590_aca4_d9c6c6dde0fc
name: HK1
is: Q59FD4
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:3098
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_0f6f72ff_cdc1_4c94_bf8d_fe88e6694b3a
has only substance units: false
constant: false
name: RRM2B
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
is: Q7LG56
is encoded by: hsa:50484

http://identifiers.org/biomodels.db/MODEL1310110012#_5b20bf77_158f_4bba_9dce_7987b3c47f43
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: Q9UMR5
is encoded by: hsa:9374
has only substance units: false
name: PPT2
type: Species

metaR RETI2
reversible: true
is: SBO:0000176
type: Reaction
product: MODEL1310110012#
fast: false
name: retinol isomerase (9-cis)
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
reactant: MODEL1310110012#

metaR C141OHe
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:1-OH
type: Reaction

metaR r1636
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
reversible: true
product: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR G14T18g
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110012#
is: SBO:0000176
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110012#_090af69f_1f8a_4713_971a_9dee90aac44d
name: DGUOK
is: SBO:0000252
type: Species
is: E5KSL5
is encoded by: hsa:1716
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR r1639
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110012#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
is: SBO:0000185

metaR NACHEX15ly
product: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110012#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false

metaR FBP26
notes: GENE_ASSOCIATION: (2203.1) or (5210.1) or (5207.1) or (5209.1) or (5208.1) or (8789.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 3.1.3.46 Confidence Level: 0 AUTHORS: NOTES:IF
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.1.3.11
name: Fructose-2,6-bisphosphate 2-phosphatase
reactant: MODEL1310110012#
fast: false
is described by: ECO:0000000
product: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.105
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110012#

metaR ADPCOACROT
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoyl carnitine
type: Reaction

metaR S6TASE9ly
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: true
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
product: MODEL1310110012#
modifier: MODEL1310110012#
name: N-acetylgalactosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR C102CPT1
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decadienoylcarnitine
type: Reaction

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_79c31075_5b2d_4ab8_9cde_d85563d56290
initial amount: NaN
constant: false
name: SLC19A1
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is: P41440
is encoded by: hsa:6573

metaM stcrn m
name: stearoylcarnitine
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
has only substance units: false
type: Species
is: HMDB00848
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0

metaM leuleu c
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C12H24N2O3 CHARGE: 0
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/94244
has only substance units: false
name: Leucylleucine

http://identifiers.org/biomodels.db/MODEL1310110012#_8ae85d7a_3c82_43c9_9589_3435b64c6f25
is encoded by: hsa:89874
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: G3V4L5
name: SLC25A21
is: SBO:0000252
boundary condition: true
constant: false
type: Species

metaM h2o2 n
initial concentration: 1.0
is: CHEBI:16240
type: Species
is: HMDB03125
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: SBO:0000247
constant: false
name: hydrogen peroxide
initial amount: NaN
has only substance units: false
boundary condition: false

metaR r1638
type: Reaction
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
reversible: true
product: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM mev R c
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
name: (R)-mevalonate
boundary condition: false
is: CHEBI:36464
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
constant: false
is: HMDB00227

metaR PYRt2p
product: MODEL1310110012#
name: pyruvate peroxisomal transport via proton symport
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12705896,PMID:12739169,PMID:9786900 NOTES:NCD
reactant: MODEL1310110012#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110012#
reversible: true
modifier: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_fe8da4a8_8a65_4aed_b3f9_431c8fc287a7
constant: false
is encoded by: hsa:2109
has only substance units: false
is: SBO:0000252
type: Species
name: ETFB
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR UMPK2
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
type: Reaction
name: UMP kinase (CTP)
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110012#_f5ea810c_5a51_49b5_8357_1d52157db448
has only substance units: false
initial concentration: NaN
is: Q14376
initial amount: NaN
constant: false
name: GALE
boundary condition: true
is encoded by: hsa:2582
type: Species
is: SBO:0000252

metaR FATP9t
type: Reaction
name: fatty acid electroneutral transport
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110012#
reversible: true
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is described by: ECO:0000269
modifier: MODEL1310110012#
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/6.2.1.7
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_10e58c95_1a37_475a_8782_5499f965d959
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:57835
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: Q9BY07
name: SLC4A5

metaR MG2er
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
is: SBO:0000176
product: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110012#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110012#_06f752ae_43eb_43b9_bcf8_9b26221e56ee
initial concentration: NaN
constant: false
is: SBO:0000252
is: P31213
has only substance units: false
name: SRD5A2
initial amount: NaN
boundary condition: true
is encoded by: hsa:6716
type: Species

metaM adrn c
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
is: HMDB02226
is: CHEBI:53487
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: adrenic acid

http://identifiers.org/biomodels.db/MODEL1310110012#_ce3a6eca_aa48_4bdf_a8f1_a3318bac2d8f
initial amount: NaN
type: Species
is: SBO:0000252
is: Q4J699
has only substance units: false
is encoded by: hsa:491
initial concentration: NaN
name: ATP2B2
constant: false
boundary condition: true

metaM h2o2 m
constant: false
is: HMDB03125
initial amount: NaN
has only substance units: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: CHEBI:16240
type: Species
name: Hydrogen peroxide
boundary condition: false
initial concentration: 1.0
is: C00027
is: SBO:0000247

metaM c12dc c
initial amount: NaN
is: HMDB00623
initial concentration: 1.0
notes: FORMULA: C19H34NO6 CHARGE: -1
is: SBO:0000247
boundary condition: false
name: dodecanedioyl carnitine
type: Species
has only substance units: false
constant: false

metaR r2308
is: SBO:0000185
reversible: true
reactant: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110012#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110012#_7df1a756_d18d_4c8c_9d59_e13d2dd31cc9
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:5152
name: PDE9A
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false

metaR r2133
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000185
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_37ba98e1_591c_4971_aeb2_f61c0df3b58d
type: Species
initial amount: NaN
boundary condition: true
is: Q86YI5
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:1737
name: DLAT

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaM ksii core4 pre5 g
type: Species
constant: false
is: SBO:0000247
boundary condition: false
is: C00130
notes: FORMULA: C69H112N6O48X CHARGE: -1
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 5
initial amount: NaN
has only substance units: false
is: CHEBI:58053
initial concentration: 1.0

metaR GLXtp
name: glyoxylate transport, peroxisomal
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000000
product: MODEL1310110012#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
reversible: true
fast: false

metaM tdchola x
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
name: taurochenodeoxycholate
is: CHEBI:9407
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: HMDB00951

http://identifiers.org/biomodels.db/MODEL1310110012#_metaM_galacglcgal14acglcgalgluside_hs_g
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:26174
name: i-antigen
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0
constant: false

metaM chito2pdol U c
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:12427
notes: FORMULA: C1185H1940N20O170P20 CHARGE: -20
constant: false
type: Species
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human uterine homolog

http://identifiers.org/biomodels.db/MODEL1310110012#_600dd98e_eb22_441a_b402_55d0839ffc26
name: ATP5D
initial amount: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
is encoded by: hsa:513
is: SBO:0000252
initial concentration: NaN
is: P30049

metaR UMPK3
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (UTP)
kinetic law: MODEL1310110012#
is: SBO:0000176
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110012#
fast: false

metaR C5DCe
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of glutaryl carnitine into the extra cellular fluid
type: Reaction

metaR r2309
is described by: ECO:0000000
product: MODEL1310110012#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction

metaR NDP7er
is described by: ECO:0000000
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
product: MODEL1310110012#
reversible: false
fast: false
is: SBO:0000176
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
type: Reaction

metaM g6p r
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: C00092
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: SBO:0000247
name: D-Glucose 6-phosphate
is: HMDB01401
constant: false
has only substance units: false
is: CHEBI:61548

http://identifiers.org/biomodels.db/MODEL1310110012#_7778654d_d3fd_4568_a50d_cd07f90aed98
initial amount: NaN
name: CA5B
type: Species
is: Q9Y2D0
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:11238

metaR PYRt2r
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110012#
is described by: ECO:0000269
fast: false
name: pyruvate reversible transport via proton symport
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
reversible: true

metaR DNDPt25m
is described by: ECO:0000269
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110012#
fast: false
name: dTDP transport via dCDP antiport

http://identifiers.org/biomodels.db/MODEL1310110012#_1ad5d692_6849_447c_b509_5e1f966bbe7a
is: SBO:0000252
boundary condition: true
is encoded by: hsa:506
type: Species
initial concentration: NaN
is: P06576
has only substance units: false
name: ATP5B
initial amount: NaN
constant: false

metaR r0835
type: Reaction
reversible: true
modifier: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
is described by: ECO:0000000

metaR UMPK4
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
reactant: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
is described by: ECO:0000269
name: UMP kinase (GTP)
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110012#_ae2110f9_9d14_4089_abaa_e64934bc7f25
is encoded by: hsa:5295
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: E7EX19
type: Species
constant: false
name: PIK3R1
has only substance units: false

metaR ATPtx
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
product: MODEL1310110012#
is: SBO:0000185
kinetic law: MODEL1310110012#
reversible: true
name: ATP transporter, peroxisomal
reactant: MODEL1310110012#

metaM hmgcoa c
is: HMDB01375
type: Species
initial concentration: 1.0
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:15467
name: Hydroxymethylglutaryl-CoA
boundary condition: false

metaR DCSPTN1CPT1
fast: false
reactant: MODEL1310110012#
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
type: Reaction
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_beaecdf7_c8ef_488d_9ef6_b3ba98c136a4
is: P30520
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
name: ADSS
is encoded by: hsa:159
initial amount: NaN
initial concentration: NaN

metaR UMPK5
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
fast: false
product: MODEL1310110012#
name: UMP kinase (dATP)
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110012#_deb1fc4f_da4f_458a_be27_0e91eb12c177
is encoded by: hsa:1350
is: P15954
name: COX7C
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false

metaR FAOXC17C15m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C17-->C15)m
type: Reaction

metaM biocyt c
is: HMDB03134
is: C05552
name: Biocytin
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/7886
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552

metaR NDP7ex
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
product: MODEL1310110012#
modifier: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
type: Reaction
name: nucleoside-diphosphatase (UDP), extracellular
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.6
reversible: false
is: SBO:0000176

metaM m1mpdol U c
notes: FORMULA: C1305H2140N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
is: CHEBI:28067
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_9a56f062_31b5_4083_9f52_92643e4e34da
is encoded by: hsa:9167
is: Q6FGA0
type: Species
boundary condition: true
name: COX7A2L
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR Coqe
name: Transport of q10
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reversible: true
fast: false

metaR PYRt2m
fast: false
product: MODEL1310110012#
is: SBO:0000185
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110012#
name: pyruvate mitochondrial transport via proton symport
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD

metaR EX tdcrn
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for myristoyl carnitine
type: Reaction

metaM trp L e
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
has only substance units: false
initial amount: NaN
is: CHEBI:16828
is: HMDB00929
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
name: L-tryptophan

http://identifiers.org/biomodels.db/MODEL1310110012#_4e557a9a_2bcd_4049_94a3_7b3a31632c6c
is: Q3KQV9
constant: false
is encoded by: hsa:91373
is: SBO:0000252
name: UAP1L1
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species

metaR r2139
reactant: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110012#
reversible: true
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110012#

metaR C181OHc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecenoylcarnitinec
type: Reaction

metaR DCSPTN1CPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110012#
is described by: ECO:0000000
reactant: MODEL1310110012#
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
reversible: false
is: SBO:0000176
name: carnitine transferase
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

metaM hx2coa m
type: Species
is: SBO:0000247
name: trans-Hex-2-enoyl-CoA
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: HMDB06870
is: C05998
is: http://identifiers.org/pubchem.compound/11966188
constant: false
initial concentration: 1.0

metaR UMPK6
modifier: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
kinetic law: MODEL1310110012#
fast: false
product: MODEL1310110012#
name: UMP kinase (dCTP)
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110012#_fd6450db_bec5_4eae_b436_964fe05574ec
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:2593
has only substance units: false
name: GAMT

http://identifiers.org/biomodels.db/MODEL1310110012#_60e7b76c_03b4_4bb1_a501_204d1c61d98c
initial concentration: NaN
is encoded by: hsa:60386
constant: false
is: Q9HC21
boundary condition: true
name: SLC25A19
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_5f145c48_deb8_43ce_8581_697c741d8795
is: Q9BYZ2
has only substance units: false
is encoded by: hsa:92483
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
name: LDHAL6B

metaM tmndnc e
boundary condition: false
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
name: timnodonic acid C20:5, n-3
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB01999
constant: false
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/446284

metaR PNTOte
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110012#
reversible: true
name: Transport of (R)-Pantothenate
product: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110012#

metaM m2mpdol U c
constant: false
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
is: CHEBI:28049
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C1365H2240N20O320P20 CHARGE: -20
type: Species

metaM fe2 c
initial concentration: 1.0
is: C00023
is: CHEBI:29033
name: Fe2+
boundary condition: false
has only substance units: false
is: HMDB00692
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023

http://identifiers.org/biomodels.db/MODEL1310110012#_0d76f8f6_fe71_47b3_b1c5_73c69a9d86e0
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
name: ALG2
has only substance units: false
is encoded by: hsa:85365
is: SBO:0000252
boundary condition: true

metaR LGNCCOAtx
kinetic law: MODEL1310110012#
name: fatty acid intracellular transport
product: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
reactant: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110012#_7acdce7a_3f3d_4b66_9918_a7fc83005cb1
name: SI
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:6476
is: P14410
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_512d5b6f_81f8_4ac1_a9f0_552965c93028
is encoded by: hsa:6901
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q16635
constant: false
initial concentration: NaN
name: TAZ
type: Species

metaR r0830
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110012#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.5.4.16
product: MODEL1310110012#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
modifier: MODEL1310110012#

metaM adrncoa c
constant: false
is: http://identifiers.org/pubchem.compound/47205480
is: C16170
type: Species
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: adrenyl coenzyme A
has only substance units: false
initial concentration: 1.0

metaR UMPK7
reversible: true
is: SBO:0000176
fast: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (dGTP)

metaR LEUKTRD4t
kinetic law: MODEL1310110012#
reversible: true
name: leukotriene D4 transport
reactant: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
product: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110012#_a342b837_88cb_4314_9f4f_b4cf2aab4ea5
has only substance units: false
name: SMPD3
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: A8K0T6
is encoded by: hsa:55512
boundary condition: true

metaR r2137
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
fast: false
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110012#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
modifier: MODEL1310110012#

metaM anth c
name: anthranilate
type: Species
initial amount: NaN
is: HMDB01123
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
is: CHEBI:16567

http://identifiers.org/biomodels.db/MODEL1310110012#_e72a8b73_681b_49d4_9ac6_293cd156f597
has only substance units: false
name: UGP2
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is: Q16851
is: SBO:0000252
is encoded by: hsa:7360
initial amount: NaN

metaM trp L c
has only substance units: false
constant: false
is: CHEBI:16828
initial amount: NaN
is: HMDB00929
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: L-tryptophan
type: Species
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080

metaR NMNATr
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: nicotinamide-nucleotide adenylyltransferase
is: SBO:0000176
kinetic law: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
modifier: MODEL1310110012#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.7.1
reversible: true

metaR DM ethamp r
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaR FUM
is: SBO:0000176
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
product: MODEL1310110012#
modifier: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
name: fumarase
is version of: http://identifiers.org/ec-code/4.2.1.2
fast: false
is described by: ECO:0000000

metaR MTHGXLt
type: Reaction
kinetic law: MODEL1310110012#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
name: Methylglyoxal transport (cytosol to extracellular)
is: SBO:0000185
fast: false
product: MODEL1310110012#
reactant: MODEL1310110012#

metaR ASCBt4
is described by: ECO:0000269
product: MODEL1310110012#
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
name: L-ascorbate transport via proton symport

http://identifiers.org/biomodels.db/MODEL1310110012#_03d225cc_a47e_422d_8cdb_2ecb0ff6f89a
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:259230
boundary condition: true
initial amount: NaN
is: D3DWC4
has only substance units: false
name: SGMS1

metaM 2mp2coa m
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
has only substance units: false
constant: false
is: SBO:0000247
type: Species
boundary condition: false
name: 2-Methylprop-2-enoyl-CoA
initial concentration: 1.0
is: CHEBI:27754
is: HMDB01011
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_27c8e48f_d033_4306_95ad_02421a55f72f
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
name: SLC4A5
is encoded by: hsa:57835
initial concentration: NaN

metaR DHPM1
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.2.2
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reversible: false
reactant: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
name: dihydropyrimidinase (5,6-dihydrouracil)
is: SBO:0000176
fast: false
type: Reaction

metaM mlthf c
boundary condition: false
is: CHEBI:15636
initial concentration: 1.0
is: HMDB01533
has only substance units: false
is: C00143
constant: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: SBO:0000247
type: Species
initial amount: NaN
name: 5,10-Methylenetetrahydrofolate

metaR FAOXC12C12OHm
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->OHC12)m
type: Reaction

metaM tmndnc c
is: http://identifiers.org/pubchem.compound/446284
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: HMDB01999
constant: false
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
name: timnodonic acid C20:5, n-3
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_0d9bcc11_9527_45d1_a4e7_e5687f567209
is: SBO:0000252
is: P53597
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:8802
boundary condition: true
name: SUCLG1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_c4d21a00_177f_4095_b32a_e832e732f551
boundary condition: true
is: O75354
type: Species
is encoded by: hsa:955
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ENTPD6

metaM hs deg6 l
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
name: heparan sulfate, degradation product 6
is: SBO:0000247
constant: false
is: HMDB06210
boundary condition: false

metaM accoa x
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57288
initial amount: NaN
boundary condition: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
name: Acetyl-CoA
is: C00024
is: HMDB01206
initial concentration: 1.0
type: Species

metaM tdcoa c
initial concentration: 1.0
is: C02593
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB01521
boundary condition: false
is: CHEBI:57385
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
name: Tetradecanoyl-CoA (n-C14:0CoA)

metaR FAOXC141C121x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C14:1-->C12:1)x
type: Reaction

metaR r0829
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
reactant: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110012#
fast: false
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/4.1.1.37
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110012#_84534c4f_649b_4694_9f79_291ca7b2e7f5
is: Q16134
name: ETFDH
has only substance units: false
is encoded by: hsa:2110
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_9d8a1e6b_4bfc_4f00_8b44_06b2664373ff
constant: false
name: PANK1
is: Q8TE04
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:53354

metaM tetdec2crn e
notes: FORMULA: C21H37NO4 CHARGE: 0
is: SBO:0000247
has only substance units: false
boundary condition: false
name: tetradecadienoyl carnitine
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB05066
type: Species

metaR HXPRT
type: Reaction
reversible: false
is described by: ECO:0000269
product: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
modifier: MODEL1310110012#
is: SBO:0000176
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
reactant: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.8

metaR BUTt2m
fast: false
reversible: true
modifier: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000000
name: Butyrate mitochondrial transport via proton symport, reversible
product: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110012#

metaM c4dc c
is: C02862
name: succinyl carnitine
is: http://identifiers.org/pubchem.compound/213144
is: HMDB02013
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C11H18NO6 CHARGE: -1
type: Species
initial concentration: 1.0

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaR PRGNLONEtm
name: pregnenolone intracellular transport
reactant: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110012#

metaR r2140
modifier: MODEL1310110012#
product: MODEL1310110012#
fast: false
reversible: true
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
is: SBO:0000185

metaR UREAtm
fast: false
product: MODEL1310110012#
is: SBO:0000185
notes: GENE_ASSOCIATION: (366.1) SUBSYSTEM: Urea cycle EC Number: Confidence Level: 2 AUTHORS: PMID:12096044,PMID:16126913,PMID:9733774 NOTES:JLR SAB m
modifier: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: true
name: Urea transport via diffusion
type: Reaction
is described by: ECO:0000304

metaM gdpfuc g
is: SBO:0000247
is: HMDB01095
has only substance units: false
constant: false
is: CHEBI:57984
type: Species
initial concentration: 1.0
boundary condition: false
name: GDP-L-fucose(2-)
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
initial amount: NaN

metaM sebacid x
boundary condition: false
constant: false
initial concentration: 1.0
name: sebacicacid
notes: FORMULA: C10H16O4 CHARGE: -2
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB00792
is: C08277

http://identifiers.org/biomodels.db/MODEL1310110012#_4178e01d_3ede_4fd1_9aa8_bc79fccdc581
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
name: AGPAT3
has only substance units: false
initial concentration: NaN
is: Q9NRZ7
is encoded by: hsa:56894

metaR GAPD
is version of: http://identifiers.org/ec-code/1.2.1.12
reversible: true
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
is: SBO:0000176
product: MODEL1310110012#
type: Reaction
modifier: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
name: glyceraldehyde-3-phosphate dehydrogenase
is described by: ECO:0000134
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_3f894d7d_6009_474a_a6c7_8eeb06640baf
is encoded by: hsa:10637
initial concentration: NaN
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
name: LEFTY1
is: O75610
has only substance units: false

metaM dcmp c
has only substance units: false
is: HMDB01202
is: CHEBI:57566
is: C00239
boundary condition: false
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
name: dCMP
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_a0b2b6bd_83b0_4718_8842_feb7f4198076
initial amount: NaN
type: Species
is: Q13630
has only substance units: false
name: TSTA3
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:7264

metaM h2o2 e
type: Species
initial amount: NaN
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125
is: SBO:0000247
name: hydrogen peroxide
initial concentration: 1.0
boundary condition: false
is: CHEBI:16240
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_58d089d5_c2b9_4c83_a2cb_881fa628e51a
is: P27815
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5141
initial amount: NaN
name: PDE4A
type: Species
initial concentration: NaN
constant: false
has only substance units: false

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_87ebfe46_4e8d_463d_871a_f1d5d13c1b42
boundary condition: true
constant: false
is encoded by: hsa:116285
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
name: ACSM1
is: Q08AH1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_d117e1a6_78c9_4220_9142_249df1bf8e6c
boundary condition: true
name: SLC23A2
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:9962

metaM CE5121 m
boundary condition: false
initial concentration: 1.0
is: CHEBI:57449
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
has only substance units: false
constant: false
name: trans-3-decenoyl-CoA

metaR N2M2NMASNtly
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
name: n2m2nmasn transport, extracellular to lysosome
product: MODEL1310110012#
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_8e5000ba_2f5c_4a09_a84e_97c156ed8aab
initial concentration: NaN
constant: false
initial amount: NaN
name: _AI191472_1_c
type: Species
boundary condition: true
is encoded by: hsa:AI191472
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110012#_5088b99e_8eaa_48d3_b933_d5f62e1a26aa
initial amount: NaN
is encoded by: hsa:8897
initial concentration: NaN
name: MTMR3
is: Q13615
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
constant: false

metaM tetdec2crn c
type: Species
has only substance units: false
is: HMDB02014
is: SBO:0000247
boundary condition: false
name: tetradecadienoyl carnitine
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C21H37NO4 CHARGE: 0

metaR PHYHx
is version of: http://identifiers.org/ec-code/1.14.11.18
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
name: Phytanoyl-CoA dioxygenase, peroxisomal
type: Reaction
is: SBO:0000176
reactant: MODEL1310110012#
fast: false
product: MODEL1310110012#
reversible: false
notes: GENE_ASSOCIATION: (5264.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.14.11.18 Confidence Level: 4 AUTHORS: PMID:8954107,PMID:9326940 NOTES:NJ
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110012#_fa2ee4f4_8f70_42cb_9d13_5fbbbadf97c7
constant: false
name: OTC
is: P00480
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5009

http://identifiers.org/biomodels.db/MODEL1310110012#_34e67dc3_9847_4aeb_8f3b_596b05920781
is: SBO:0000252
initial concentration: NaN
name: PLCE1
is: Q9P212
constant: false
is encoded by: hsa:51196
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true

metaR ASPTA
is version of: http://identifiers.org/ec-code/2.6.1.1
type: Reaction
fast: false
kinetic law: MODEL1310110012#
reversible: true
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
reactant: MODEL1310110012#
is described by: ECO:0000269
name: aspartate transaminase
is: SBO:0000176
product: MODEL1310110012#

metaM hgentis c
has only substance units: false
initial amount: NaN
is: CHEBI:16169
constant: false
type: Species
is: HMDB00130
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
name: homogentisate
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR GLYt7 211 r
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reversible: true
is: SBO:0000185
reactant: MODEL1310110012#
type: Reaction
modifier: MODEL1310110012#
name: glycine reversible transport via sodium and chloride symport (2:1:1)

metaM emgacpail hs r
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C39H74N2O22P2FULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: phosphoethanolaminyl-mannosyl-glucosylaminyl-acylphosphatidylinositol (H5)
is: CHEBI:16038
boundary condition: false

metaR THMTPt
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (6573.1) or (6573.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10542220,PMID:14770311 NOTES:IT
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110012#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reversible: false
name: Thiamine triphosphate transport in via anion antiport

metaR SERPT
reversible: false
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
is: SBO:0000176
modifier: MODEL1310110012#
name: serine C-palmitoyltransferase
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.50
type: Reaction
is described by: ECO:0000269

metaM dgchol e
is: HMDB00637
constant: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: SBO:0000247
name: glycochenodeoxycholate
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:36252
initial amount: NaN
type: Species

metaM ksi deg29 l
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
is: CHEBI:12936
name: keratan sulfate I, degradation product 29
is: SBO:0000247
is: HMDB00143
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_1208086c_c0a0_49b2_91fc_b8c25838e47e
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:51227
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
constant: false
boundary condition: true

metaM ksi deg20 l
boundary condition: false
initial concentration: 1.0
is: HMDB00143
name: keratan sulfate I, degradation product 20
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:12936
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
constant: false
has only substance units: false

metaM L2aadp m
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
constant: false
type: Species
initial amount: NaN
is: HMDB00510
boundary condition: false
is: CHEBI:58672
name: L-2-aminoadipate(1-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_f065c487_cf65_4513_9356_655062700fb5
is: SBO:0000252
is encoded by: hsa:126328
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: C9JT23
initial amount: NaN
type: Species
name: NDUFA11

metaM 13dampp c
boundary condition: false
name: trimethylenediaminium
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00002
has only substance units: false
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
type: Species
is: CHEBI:57484
is: SBO:0000247

metaR FAOXC16BRx
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16br)x
type: Reaction

metaM apoC m
name: Apocarboxlase (no lys residue)
boundary condition: false
constant: false
type: Species
notes: FORMULA: XH CHARGE: 0
initial concentration: 1.0
is: CHEBI:32551
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00182

metaR DPMVDc
reversible: false
modifier: MODEL1310110012#
is described by: ECO:0000134
kinetic law: MODEL1310110012#
is: SBO:0000176
product: MODEL1310110012#
name: diphosphomevalonate decarboxylase, cytosol
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added t product for elemental balancing.
is version of: http://identifiers.org/ec-code/4.1.1.33
type: Reaction
reactant: MODEL1310110012#
fast: false

metaR AMETtd
fast: false
is: SBO:0000185
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110012#
name: diffusion of S-Adenosyl-L-methionine
type: Reaction
reversible: true
is described by: ECO:0000134
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_4062dc79_b985_4b2e_93b4_64b51743be1f
has only substance units: false
initial amount: NaN
is encoded by: hsa:9107
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is: Q9Y217
initial concentration: NaN
name: MTMR6

http://identifiers.org/biomodels.db/MODEL1310110012#_9ebaca40_6ea8_4f8a_a2db_9f49f5d83795
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is: E7EPA7
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:7086
name: TKT

metaM gpi sig r
is: HMDB00224
notes: FORMULA: Y CHARGE: 0
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
type: Species
is: CHEBI:58190
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false

metaR DOLPMT3 Uer
is described by: ECO:0000000
product: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.4.1.260
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
type: Reaction
reversible: false

metaM 2mb2coa m
is: HMDB02054
is: CHEBI:57337
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
boundary condition: false
constant: false
name: 2-methylcrotonoyl-CoA(4-)
type: Species

metaR BTNPL
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
name: holocarboxylase synthestase (biotin protein ligase)
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/6.3.4.10

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaM c5dc c
type: Species
initial concentration: 1.0
constant: false
name: glutaryl carnitine
is: HMDB13130
boundary condition: false
notes: FORMULA: C12H21NO6 CHARGE: 0
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR H2O2tp
fast: false
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
product: MODEL1310110012#
name: hydrogen peroxide peroxisomal transport via diffusion
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaR G3PD1
kinetic law: MODEL1310110012#
is described by: ECO:0000269
name: glycerol-3-phosphate dehydrogenase (NAD)
is: SBO:0000176
modifier: MODEL1310110012#
reactant: MODEL1310110012#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
fast: false
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.1.1.8

metaR HDD2COAtx
type: Reaction
product: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: hdd2coa intracellular transport
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_5caf0aa5_8d39_4e2e_8898_e6cf68f9ac14
type: Species
initial amount: NaN
is encoded by: hsa:6391
constant: false
has only substance units: false
initial concentration: NaN
name: SDHC
is: Q99643
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_4128fbbe_4dbc_4bf3_822a_198f45f72a9d
is: SBO:0000252
is encoded by: hsa:8760
initial concentration: NaN
is: O95674
initial amount: NaN
name: CDS2
constant: false
boundary condition: true
type: Species
has only substance units: false

metaR r1466
kinetic law: MODEL1310110012#
is described by: ECO:0000000
type: Reaction
name: EC:2.3.1.86
reactant: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
fast: false
product: MODEL1310110012#
reversible: true

metaR ACALDt
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: acetaldehyde reversible transport
reactant: MODEL1310110012#
type: Reaction

metaR NADPtxu
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
product: MODEL1310110012#
name: NADP transporter, peroxisome
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ potential for free H NJ
fast: false
reversible: false

metaR C4STMO1r
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.14.13.72
modifier: MODEL1310110012#
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
kinetic law: MODEL1310110012#
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110012#_b8e2ffd0_3456_4fee_93e9_e51f2e67a54f
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: PDE9A
is encoded by: hsa:5152
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM mmcoa S m
name: (S)-methylmalonyl-CoA(5-)
type: Species
is: CHEBI:57327
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
has only substance units: false
is: HMDB02310

metaM ksii core2 g
is: HMDB03418
is: CHEBI:16443
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
name: keratan sulfate II (core 2-linked)
type: Species

metaM 3mop e
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00491
name: 3-methyl-2-oxopentanoate
is: CHEBI:28654
has only substance units: false

metaM grdp x
constant: false
type: Species
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
initial concentration: 1.0
name: geranyl diphosphate(3-)
initial amount: NaN
is: CHEBI:58057
has only substance units: false
is: HMDB01285
is: SBO:0000247
boundary condition: false

metaM dgchol c
initial amount: NaN
is: HMDB00637
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:36252
name: glycochenodeoxycholate
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
constant: false

metaR GLCAASE7ly
is: SBO:0000176
reactant: MODEL1310110012#
name: beta-glucuronidase, lysosomal
kinetic law: MODEL1310110012#
product: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_105196b1_bbfe_456b_9ad3_dfdf2c2d7974
is encoded by: hsa:107
name: ADCY1
is: Q08828
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_48e94532_072a_4ffb_a1c6_2dd34ae2f1fb
is encoded by: hsa:6799
name: SULT1A2
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM ac c
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:30089
boundary condition: false
initial amount: NaN
name: acetate
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: HMDB00042
type: Species

metaR r0531
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
is version of: http://identifiers.org/ec-code/1.1.1.34
is described by: ECO:0000000
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000176
product: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
fast: false

metaR GUAPRT
type: Reaction
is: SBO:0000176
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.4.2.8
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
name: guanine phosphoribosyltransferase
is described by: ECO:0000269
reversible: false
fast: false

metaR DM Lcystin
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for L-cystine
type: Reaction

metaM gdpfuc c
boundary condition: false
is: HMDB01095
initial amount: NaN
is: CHEBI:57984
constant: false
type: Species
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
has only substance units: false
is: SBO:0000247
name: GDP-L-fucose(2-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_7432af03_1f16_415c_a3c7_6b29b73e1e00
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q3I5F7
is encoded by: hsa:641372
name: ACOT6
initial amount: NaN

metaR r1788
reactant: MODEL1310110012#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110012#
name: Y+LAT2 Utilized transport

metaM 4mop c
constant: false
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
name: 4-methyl-2-oxopentanoate
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:17865
is: HMDB00695
initial concentration: 1.0

metaR H2Ot
reactant: MODEL1310110012#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:renamed from H20t5 to H2Ot NCD
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110012#
name: H2O transport via diffusion
modifier: MODEL1310110012#
product: MODEL1310110012#
reversible: true

metaM adrn e
boundary condition: false
name: adrenic acid
is: SBO:0000247
has only substance units: false
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
is: HMDB02226
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:53487

http://identifiers.org/biomodels.db/MODEL1310110012#_b9d7e709_629d_4a36_a9eb_5badb355e22e
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:221
name: ALDH3B1
is: P43353
initial concentration: NaN
type: Species

metaR EX CE5869 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lysyl-proline exchange
type: Reaction

metaR MM8Cg
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000000
modifier: MODEL1310110012#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
product: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.113
type: Reaction
fast: false
reversible: false

metaR r1921
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110012#
reversible: false
name: Y+LAT2 Utilized transport
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110012#
modifier: MODEL1310110012#

metaR r1464
kinetic law: MODEL1310110012#
name: Active transport
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
product: MODEL1310110012#
fast: false

metaM 3mop c
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
is: HMDB00491
initial amount: NaN
has only substance units: false
is: CHEBI:28654

http://identifiers.org/biomodels.db/MODEL1310110012#_c9f10ee8_b74b_4f28_a5e6_863e45c22954
name: CHST5
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:23563
is: Q9GZS9
has only substance units: false

metaR GLXtm
name: glyoxylate transport, mitochondrial
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110012#_ac55feb2_9920_4810_af0f_1360925db1c4
is encoded by: hsa:5831
is: SBO:0000252
is: A6NFM2
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: PYCR1
boundary condition: true
initial amount: NaN

metaR r1789
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
reversible: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
fast: false
kinetic law: MODEL1310110012#
is: SBO:0000185
product: MODEL1310110012#

metaR r2142
reactant: MODEL1310110012#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110012#
is described by: ECO:0000000
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110012#
reversible: true
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR PFK26
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.105
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110012#
name: 6-phosphofructo-2-kinase
notes: GENE_ASSOCIATION: (5210.1) or (5207.1) or (5209.1) or (5208.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.105 Confidence Level: 0 AUTHORS: NOTES:IF
type: Reaction
product: MODEL1310110012#
fast: false

metaM ksii core2 e
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: CHEBI:17268
is: HMDB00211
name: keratan sulfate II (core 2-linked)
boundary condition: false

metaM cs e l
has only substance units: false
initial amount: NaN
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
type: Species
constant: false
is: SBO:0000247
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
is: HMDB02183
is: CHEBI:36005
initial concentration: 1.0

metaR FUMAC
kinetic law: MODEL1310110012#
reversible: false
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.7.1.2
name: fumarylacetoacetase
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_73a714d0_0e87_497a_b5d4_8ffc76fa5c94
type: Species
constant: false
is encoded by: hsa:5860
name: QDPR
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: P09417
boundary condition: true

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR FACOAL184
is: SBO:0000176
name: fatty-acid--CoA ligase
product: MODEL1310110012#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
modifier: MODEL1310110012#
reversible: true
fast: false

metaR S6TASE20ly
is described by: ECO:0000000
product: MODEL1310110012#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110012#

metaR BUTt2r
is described by: ECO:0000269
modifier: MODEL1310110012#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reversible: true
reactant: MODEL1310110012#
fast: false
name: Butyrate transport via proton symport, reversible
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR

metaM ac e
constant: false
is: CHEBI:30089
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00042
name: acetate
boundary condition: false

metaM tetdec2coa c
name: tetradecadienoylcoa
constant: false
has only substance units: false
is: HMDB02014
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C35H54N7O17P3S CHARGE: -4

metaR FAOXC102C103m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaM c5dc e
notes: FORMULA: C12H21NO6 CHARGE: 0
is: HMDB13130
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: glutaryl carnitine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_ac5f39b8_2401_493f_b81d_573f3e398efc
is encoded by: hsa:6005
is: Q96E98
boundary condition: true
has only substance units: false
constant: false
name: RHAG
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252

metaM s2l2n2m2m l
notes: FORMULA: C84H136N6O62 CHARGE: -2
has only substance units: false
type: Species
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00573
is: CHEBI:30825
name: de-Fuc form of PA6 (w/o peptide linkage)
initial concentration: 1.0

metaR r2141
reversible: true
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110012#
fast: false
product: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110012#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR SCPx
is version of: http://identifiers.org/ec-code/2.3.1.176
is: SBO:0000176
fast: false
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000269
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
reactant: MODEL1310110012#
name: peroxisomal thiolase 2

metaR r2035
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000185
reversible: false
type: Reaction
reactant: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_metaR_EX_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIA glycolipid exchange
type: Reaction

metaR FAOXC11C9m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C11-->C9)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_805ab43f_ddc5_480b_b632_1d3e8c0b2dcc
type: Species
is: Q6IZA2
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: FUT1
initial amount: NaN
is encoded by: hsa:2523

metaM L2aadp c
name: L-2-aminoadipate(1-)
is: SBO:0000247
is: CHEBI:58672
has only substance units: false
type: Species
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00510
boundary condition: false

metaR RE2974C
name: RE2974
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.149
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.1.68
fast: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:

metaM gmp e
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: GMP(3-)
is: CHEBI:58115
constant: false
type: Species
is: HMDB01397
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_03fc5585_46c3_4480_a743_51bc3d3d7d4f
initial amount: NaN
constant: false
is encoded by: hsa:1103
is: P28329
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: CHAT

http://identifiers.org/biomodels.db/MODEL1310110012#_4335cdea_51b7_4dfb_a844_f165ac683e66
has only substance units: false
is encoded by: hsa:2990
name: GUSB
is: SBO:0000252
initial amount: NaN
type: Species
is: P08236
initial concentration: NaN
constant: false
boundary condition: true

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaM utp n
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: UTP(4-)
is: HMDB00285
is: CHEBI:46398
constant: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_3b81c578_0106_4f4e_b0cc_1a4552ea6416
has only substance units: false
initial amount: NaN
is encoded by: hsa:6582
type: Species
initial concentration: NaN
is: O15244
is: SBO:0000252
name: SLC22A2
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_3ba4afd9_98f9_4a8d_950d_4addf6500bb9
name: CPT1B
is: SBO:0000252
is encoded by: hsa:1375
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q53FV7

metaR COQ3m
is version of: http://identifiers.org/ec-code/2.1.1.114
type: Reaction
reversible: false
modifier: MODEL1310110012#
name: methyltransferase COQ3
is: SBO:0000176
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10777520,PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_2.1.1.114 IT
is described by: ECO:0000269
product: MODEL1310110012#

metaM 3ttetddcoacrn e
initial amount: NaN
boundary condition: false
notes: FORMULA: C21H37NO5 CHARGE: 0
is: HMDB02014
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
is: SBO:0000247

metaR EX oxa LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

metaR FUT16g
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
reversible: false
modifier: MODEL1310110012#
is: SBO:0000176
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.4.1.69
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110012#
name: Galactoside 2-alpha-L-fucosyltransferase 1
fast: false
reactant: MODEL1310110012#

metaR DHCR242r
is: SBO:0000176
name: 24-dehydrocholesterol reductase [Precursor]
reversible: false
fast: false
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.3.1.72
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
product: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_0599e62b_2e56_44bd_a10a_334c5cc66a82
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: E9KL42
is: SBO:0000252
constant: false
type: Species
has only substance units: false
name: ACOT1
is encoded by: hsa:641371

metaR HSD3B11
is described by: ECO:0000134
reactant: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (3283.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:16023337 NOTES:progesterone prduction measured after the incubation of human granulosa cells with pregnenolone
is: SBO:0000176
type: Reaction
fast: false
reversible: false
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.1.1.145
kinetic law: MODEL1310110012#

metaR FAOXC226
reversible: false
is: SBO:0000176
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reactant: MODEL1310110012#

metaM g6p c
name: D-Glucose 6-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
has only substance units: false
is: CHEBI:61548
is: C00092
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB01401
constant: false
initial concentration: 1.0

metaR r0688
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
is: SBO:0000176
product: MODEL1310110012#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
reactant: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#

metaR ELAIDt
type: Reaction
product: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110012#
name: fatty acid transport via diffusion
reversible: true
is described by: ECO:0000000

metaM T antigen g
type: Species
notes: FORMULA: C14H24NO10X CHARGE: 0
initial concentration: 1.0
name: T antigen (core 1)
is: CHEBI:22783
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false

metaR C181CRNt
is: SBO:0000185
name: C181 transport into the mitochondria
reversible: false
product: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
kinetic law: MODEL1310110012#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110012#
reactant: MODEL1310110012#

metaM hx2coa x
is: SBO:0000247
is: C05998
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/11966188
type: Species
initial amount: NaN
is: HMDB06870
has only substance units: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
constant: false
boundary condition: false
name: trans-Hex-2-enoyl-CoA

metaM cbp m
initial amount: NaN
notes: FORMULA: CH2NO5P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00164 EHMN_ABBREVIATION: C00169
boundary condition: false
is: C00169
name: Carbamoyl phosphate
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB01096
has only substance units: false
type: Species
is: CHEBI:58228

metaR DRBK
fast: false
is described by: ECO:0000304
reactant: MODEL1310110012#
modifier: MODEL1310110012#
name: Deoxyribokinase
is version of: http://identifiers.org/ec-code/2.7.1.15
is: SBO:0000176
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.15 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
kinetic law: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
reversible: false

metaR PTCRTD
reactant: MODEL1310110012#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
type: Reaction
is described by: ECO:0000134
name: diffusion of putriscine into the endothelial cells
kinetic law: MODEL1310110012#
fast: false
product: MODEL1310110012#

metaM nadp x
name: Nicotinamide adenine dinucleotide phosphate
is: HMDB00217
is: C00006
type: Species
constant: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
boundary condition: false
is: CHEBI:58349
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_3e598db7_aeb1_42dc_a090_2c8881b9d9eb
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:343
boundary condition: true
name: AQP8
is: O94778
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_91e9c3ac_6e9e_4234_9ef9_59688eb5a066
initial amount: NaN
is encoded by: hsa:23417
constant: false
is: SBO:0000252
initial concentration: NaN
name: MLYCD
is: O95822
has only substance units: false
type: Species
boundary condition: true

metaR AGDC
reactant: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.5.1.25
reversible: false
fast: false
name: N-acetylglucosamine-6-phosphate deacetylase
is: SBO:0000176
modifier: MODEL1310110012#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (51005.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.1.25 Confidence Level: 2 AUTHORS: NOTES:acetylglucosamine phosphate deacetylase; acetylaminodeoxyglucosephosphate acetylhydrolase; 2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase

metaR PHEtec
name: L-phenylalanine transport via diffusion (extracellular to cytosol)
is described by: ECO:0000269
reversible: true
type: Reaction
kinetic law: MODEL1310110012#
fast: false
product: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000185
notes: GENE_ASSOCIATION: (117247.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462,PMID:14624363,PMID:15659399 NOTES:SAB

metaM gmp g
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:58115
name: GMP(3-)
is: HMDB01397
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_ba2b3784_eb97_4678_a419_ef678f6e3bac
name: PIGX:PIGM
boundary condition: true
is: SBO:0000297
type: Species
has only substance units: false
is encoded by: hsa:93183
constant: false
has part: Q9H3S5
initial concentration: NaN
is encoded by: hsa:54965
has part: Q8TBF5
initial amount: NaN

metaM lac D c
type: Species
is: HMDB01311
name: (R)-lactate
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:16004
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1

metaM accoa c
is: CHEBI:57288
is: HMDB01206
type: Species
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
is: C00024
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
name: Acetyl-CoA
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_879135f5_d357_4b88_943f_f1a2ba6cd851
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:AL048840
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: _AL048840_1_c

http://identifiers.org/biomodels.db/MODEL1310110012#_0ccb03c1_690f_4eff_ba96_553bce61d47f
boundary condition: true
is encoded by: hsa:957
initial concentration: NaN
is: SBO:0000252
name: ENTPD5
has only substance units: false
initial amount: NaN
type: Species
is: O75356
constant: false

metaR r0686
product: MODEL1310110012#
is: SBO:0000176
fast: false
reversible: true
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.2.2
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:

metaM biocyt m
is: SBO:0000247
constant: false
name: Biocytin
boundary condition: false
is: C05552
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7886
initial amount: NaN
type: Species
is: HMDB03134
has only substance units: false
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552

http://identifiers.org/biomodels.db/MODEL1310110012#_145cdd29_2de7_49d0_a4c4_d93b868c547b
name: LYZL1
has only substance units: false
is encoded by: hsa:84569
type: Species
initial concentration: NaN
is: Q6UWQ5
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false

metaR 34DHPHEt
product: MODEL1310110012#
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000185
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:NCD
fast: false
type: Reaction
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110012#
name: 3,4-Dihydroxy-L-phenylalanine transport

metaM dtdp e
is: HMDB01274
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:58369
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
has only substance units: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_a799670f_c3b7_4c7d_93cc_13fcc4f6b070
is: SBO:0000297
boundary condition: true
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has part: P56134
is encoded by: hsa:522
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9551
type: Species

metaM ksi deg38 l
is: SBO:0000247
is: CHEBI:12936
type: Species
has only substance units: false
name: keratan sulfate I, degradation product 38
boundary condition: false
initial amount: NaN
is: HMDB00143
initial concentration: 1.0
notes: FORMULA: C54H91N3O41 CHARGE: 0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_20afdd16_31c8_461e_bd0a_1a4580ce8861
name: CYP2C19
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: P33261
type: Species
is encoded by: hsa:1557
is: SBO:0000252

metaR HISD
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
fast: false
is described by: ECO:0000269
name: histidase
reversible: false
product: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.3.1.3

http://identifiers.org/biomodels.db/MODEL1310110012#_fa2c2f31_138f_44ce_bd71_3985cea38035
boundary condition: true
is: Q8IWU9
is: SBO:0000252
type: Species
is encoded by: hsa:121278
constant: false
initial amount: NaN
name: TPH2
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_533aa548_7127_4142_bd38_2c7f36ed9476
is: SBO:0000252
constant: false
name: ALG6
has only substance units: false
initial concentration: NaN
is: Q9Y672
initial amount: NaN
is encoded by: hsa:29929
boundary condition: true
type: Species

metaM ade e
name: adenine
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB00034
is: SBO:0000247
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: CHEBI:16708
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_538954ff_30b1_4611_8313_d912d18af1e0
constant: false
is encoded by: hsa:10870
type: Species
has only substance units: false
boundary condition: true
name: HCST:PIK3CG
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
has part: P48736
is encoded by: hsa:5294
has part: Q9UBK5

metaM lac D e
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB01311
has only substance units: false
name: (R)-lactate
constant: false
is: CHEBI:16004
is: SBO:0000247
boundary condition: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1

metaM 3mop m
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB00491
name: 3-methyl-2-oxopentanoate
constant: false
is: CHEBI:28654
type: Species

metaR FALDH
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
is: SBO:0000176
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
reversible: true
is described by: ECO:0000269
fast: false
name: formaldehyde dehydrogenase

metaM HC02204 e
is: CHEBI:27624
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin-b1
initial amount: NaN
has only substance units: false
constant: false
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
boundary condition: false

metaR CYSGLUexR
is described by: ECO:0000304
reversible: true
name: L-cysteine/L-glutamine reversible exchanger
kinetic law: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110012#
is: SBO:0000185
reactant: MODEL1310110012#
fast: false
modifier: MODEL1310110012#

metaR r0539
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
is: SBO:0000176
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.1.1.34
fast: false
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
product: MODEL1310110012#

metaR GRTTx
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
type: Reaction
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
name: geranyltranstransferase
is described by: ECO:0000134
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110012#
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.5.1.1

metaR r2030
product: MODEL1310110012#
fast: false
modifier: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM core4 g
boundary condition: false
type: Species
name: Core 4
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:16478
notes: FORMULA: C24H40N3O15X CHARGE: 0
initial concentration: 1.0

metaM co c
initial concentration: 1.0
name: carbon monoxide
is: HMDB01361
is: SBO:0000247
boundary condition: false
is: CHEBI:17245
type: Species
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
constant: false
initial amount: NaN
has only substance units: false

metaR 2HCO3 NAt
kinetic law: MODEL1310110012#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
type: Reaction
reactant: MODEL1310110012#
modifier: MODEL1310110012#
product: MODEL1310110012#
reversible: true
is: SBO:0000185

metaM dtdp c
constant: false
initial amount: NaN
name: dTDP
is: HMDB01274
is: C00363
is: CHEBI:58369
has only substance units: false
type: Species
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM retinal cis 13 r
is: CHEBI:45487
has only substance units: false
type: Species
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: SBO:0000247
name: 13-cis-retinal
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB06220

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaR GALt4
product: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000185
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
type: Reaction
name: galactose transport via sodium symport

metaR FAOXC141C121m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C12:1)m
type: Reaction

metaR C141ACBP
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradecenoyl coa from mitochondria into cytosol
type: Reaction

metaR DGSNtm
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:3696164 NOTES:
product: MODEL1310110012#
name: deoyguanosine transport in mitochondria
type: Reaction
reversible: true
reactant: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_b640fcaa_57da_49ff_aa2e_f752974a7be7
is encoded by: hsa:509
initial amount: NaN
has only substance units: false
type: Species
has part: P56381
has part: A8K092
is encoded by: hsa:506
initial concentration: NaN
has part: P30049
is encoded by: hsa:513
has part: P36542
has part: P06576
boundary condition: true
is encoded by: hsa:498
is encoded by: hsa:514
constant: false
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is: SBO:0000297

metaM dcmp n
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB01202
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
type: Species
is: SBO:0000247
is: CHEBI:57566
has only substance units: false
constant: false
name: dCMP(2-)

metaR FAOXTC122m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization trans(C12:2)m
type: Reaction

metaM accoa g
initial amount: NaN
is: CHEBI:57288
type: Species
constant: false
name: acetyl-CoA(4-)
is: HMDB01206
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_a614df21_b356_4747_9263_2e0b55797e37
is encoded by: hsa:8277
is: B7Z7I0
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: TKTL1

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_c07c3536_d0c5_4c8a_886f_a1aa2464eba7
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
name: _R33828_1_c
is encoded by: hsa:R33828
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_metaM_acgalfucgalacglcgal14acglcgalgluside_hs_g
notes: FORMULA: C72H125N4O41FULLRCO CHARGE: 0
name: (Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1
constant: false
initial amount: NaN
is: CHEBI:61648
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR S6TASE21ly
is described by: ECO:0000000
product: MODEL1310110012#
is: SBO:0000176
kinetic law: MODEL1310110012#
type: Reaction
reversible: true
modifier: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal

metaM ade c
name: Adenine
type: Species
boundary condition: false
is: HMDB00034
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: C00147
is: CHEBI:16708
has only substance units: false
initial amount: NaN
constant: false

metaM tdchola e
is: HMDB00951
type: Species
boundary condition: false
constant: false
is: CHEBI:9407
name: taurochenodeoxycholate
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_368e7121_8333_434b_82d1_3fe2712d429f
is encoded by: hsa:T83654
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: _T83654_1_m
initial concentration: NaN
boundary condition: true
constant: false
type: Species

metaR NDPK2n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
modifier: MODEL1310110012#
is described by: ECO:0000269
kinetic law: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
reversible: true
product: MODEL1310110012#
is: SBO:0000176
reactant: MODEL1310110012#

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaM thymd c
is: SBO:0000247
boundary condition: false
is: C00214
initial amount: NaN
initial concentration: 1.0
name: Thymidine
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
has only substance units: false
type: Species
is: CHEBI:17748
constant: false
is: HMDB00273

metaM HC02204 c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
name: prostaglandin-b1
initial amount: NaN
is: CHEBI:27624
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
has only substance units: false

metaR RE3347C
is: SBO:0000176
reactant: MODEL1310110012#
fast: false
name: RE3347
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
type: Reaction
product: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110012#_277f9e79_1a10_4472_a5c9_08324ebaa418
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
name: PECR
boundary condition: true
is: Q9BY49
is: SBO:0000252
is encoded by: hsa:55825
type: Species

metaM co e
is: HMDB01361
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: carbon monoxide
boundary condition: false
is: CHEBI:17245
type: Species
constant: false
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_0e1b8866_9116_4c0f_bd08_e194d0a773ea
boundary condition: true
type: Species
name: DHCR24
has only substance units: false
constant: false
initial amount: NaN
is: Q15392
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1718

metaM ac m
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00042
is: CHEBI:30089
name: acetate
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: SBO:0000247
constant: false
type: Species

metaM h2o2 c
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB03125
boundary condition: false
is: SBO:0000247
name: Hydrogen peroxide
type: Species
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: C00027
is: CHEBI:16240
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_dea0539f_8cbe_4602_8e70_cc767ee90bdf
name: AK2
is: SBO:0000252
boundary condition: true
is encoded by: hsa:204
initial concentration: NaN
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: P54819

http://identifiers.org/biomodels.db/MODEL1310110012#_208ec4b0_1923_43e2_8b91_01e8f06bf83f
is encoded by: hsa:51179
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: HAO2
is: Q9NYQ3
initial concentration: NaN

metaR BDMT U
is described by: ECO:0000000
product: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
reversible: false
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.142
reactant: MODEL1310110012#
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)
is: SBO:0000176

metaR ASNTHRNaEx
is: SBO:0000185
kinetic law: MODEL1310110012#
name: L-threonine/L-asparagine Na-dependent exchange (Asn-L in)
product: MODEL1310110012#
modifier: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
reactant: MODEL1310110012#
type: Reaction
reversible: false

metaM ksii core2 l
constant: false
initial concentration: 1.0
is: CHEBI:16443
is: HMDB03418
type: Species
name: keratan sulfate II (core 2-linked)
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
initial amount: NaN

metaM ksii core4 deg1 l
type: Species
initial concentration: 1.0
is: HMDB00868
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
name: keratan sulfate II (core 4-linked), degradation product 1
is: CHEBI:57737
constant: false

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

metaR KSII CORE4tly
name: keratan sulfate II (core 4) transport, extracellular to lysosome
reactant: MODEL1310110012#
is described by: ECO:0000000
reversible: false
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
type: Reaction

metaR P4502C8
reactant: MODEL1310110012#
is: SBO:0000176
type: Reaction
fast: false
name: cytochrome P450 2C8
notes: GENE_ASSOCIATION: (1558.1) or (1558.2) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15579107 NOTES:paclitaxol 6 alpha hydroxylation assumed to take place on outer membrane - xenobiotic metabolism NJ
is described by: ECO:0000304
kinetic law: MODEL1310110012#
reversible: false
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.14.14.1
modifier: MODEL1310110012#

metaR EX srtn LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Serotonin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_f8e07abe_5615_4218_89f8_582f9b014253
is: P11169
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
name: SLC2A3
boundary condition: true
constant: false
is encoded by: hsa:6515

http://identifiers.org/biomodels.db/MODEL1310110012#_657dc5ea_4b4c_460b_8a11_43b07f672c29
name: TRNT1
type: Species
is: Q96Q11
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:51095
is: SBO:0000252

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaR PHEACGLNt
reversible: true
reactant: MODEL1310110012#
is described by: ECO:0000000
kinetic law: MODEL1310110012#
name: PHEACGLN extracellular transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
product: MODEL1310110012#
is: SBO:0000185
fast: false
type: Reaction

metaM arg L c
name: L-argininium(1+)
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00517
is: CHEBI:32682

metaR r1621
kinetic law: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110012#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_6e5e943d_ff41_4275_9728_1a410f6f0ba9
initial amount: NaN
type: Species
is encoded by: hsa:522
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: ATP5J

metaM ksii core4 pre4 g
type: Species
constant: false
is: C00130
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: CHEBI:58053
has only substance units: false
initial amount: NaN
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 4
is: HMDB00175
initial concentration: 1.0
is: SBO:0000247

metaR P4502C9
reactant: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (1559.1) SUBSYSTEM: Cytochrome metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:2827463,PMID:3032244 NOTES:tolbutamide 4 methyl hydroxylation assumed to take place on outer membrane - xenobiotic metabolism NJ
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: false
is: SBO:0000176
type: Reaction
name: cytochrome P450 2C9
is version of: http://identifiers.org/ec-code/1.14.13.48
product: MODEL1310110012#
is described by: ECO:0000269

metaM tststerones c
is: HMDB02833
initial concentration: 1.0
constant: false
name: testosterone sulfate
has only substance units: false
is: SBO:0000247
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1/C19H28O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h11,14-17H,3-10H2,1-2H3,(H,21,22,23)/t14-,15-,16-,17-,18-,19-/m0/s1
initial amount: NaN
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_b5db0ef2_8afa_4724_80a1_c149d0dc4bf8
constant: false
is: SBO:0000252
is encoded by: hsa:F23536
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
name: _F23536_1_m

metaM didp c
name: dIDP
constant: false
is: HMDB03536
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
is: CHEBI:28823
initial amount: NaN

metaR r1620
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_fe5ff629_ad0f_4006_8248_d23d4e8a7ffd
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI684467
boundary condition: true
name: _AI684467_1_m
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_5e3e1ce9_bf63_4c16_9c06_2f8b5224f67e
type: Species
has only substance units: false
name: GLS
constant: false
initial concentration: NaN
is: O94925
is encoded by: hsa:2744
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM dgmp c
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:57673
initial concentration: 1.0
is: HMDB01044
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: C00362
name: dGMP

metaM l2fn2m2masn g
notes: FORMULA: C68H113N4O49X CHARGE: 0
type: Species
initial amount: NaN
is: CHEBI:28067
constant: false
initial concentration: 1.0
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR FAOXC102C103x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)x
type: Reaction

metaR GALASE15ly
reactant: MODEL1310110012#
is described by: ECO:0000000
product: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110012#
reversible: false

metaR FAOXC102C81x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)x
type: Reaction

metaR EX CE2915 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-casomorphin exchange
type: Reaction

metaR ACITL
reversible: false
product: MODEL1310110012#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.3.8
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
modifier: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
name: ATP-Citrate lyase

metaR LEUTAm
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.6.1.42
fast: false
name: leucine transaminase, mitochondrial
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110012#_22b8cad9_379a_47f7_a7b7_12829c12a5cf
name: PKLR
is: P30613
boundary condition: true
constant: false
type: Species
is encoded by: hsa:5313
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR COUCOAFm
reversible: false
reactant: MODEL1310110012#
is described by: ECO:0000000
product: MODEL1310110012#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: 6.2.1.12 Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine. (EC 6.2.1.12) .
kinetic law: MODEL1310110012#
is: SBO:0000176
name: p-coumaroyl-CoA formation

metaM nadp r
is: SBO:0000247
constant: false
type: Species
name: Nicotinamide adenine dinucleotide phosphate
is: C00006
is: CHEBI:58349
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: HMDB00217

metaM 2oxoadp c
is: CHEBI:57499
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: HMDB00225
has only substance units: false
name: 2-oxoadipate(2-)
initial concentration: 1.0
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322

metaR r2408
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000185
reversible: false
product: MODEL1310110012#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_8509ab08_19ed_44c9_9068_12b0fb1e7c88
is: SBO:0000252
is: B4DG68
name: NOS1
is encoded by: hsa:4842
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true

metaM 3mob m
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:11851
is: HMDB00019
name: 3-methyl-2-oxobutanoate
has only substance units: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
boundary condition: false

metaM CE2416 x
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)/p-1/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: CE2416
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57923
constant: false
name: (2R,6S,10S)-pristanate
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false

metaM hdca l
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: CHEBI:7896
name: palmitate
boundary condition: false
initial concentration: 1.0
is: HMDB00220
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_9e1bd64d_cfb3_4a41_80d1_cde52e97b938
is: SBO:0000297
has part: A3KLL5
initial amount: NaN
is encoded by: hsa:478
name: ATP1A3:ATP1B1
has part: B7Z2T0
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:481
has only substance units: false

metaM xoltriol c
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
has only substance units: false
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
is: SBO:0000247
boundary condition: false
is: CHEBI:16496
type: Species
initial concentration: 1.0
constant: false
is: HMDB01457

metaR C4x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of butyrylcoa to butyrylcarnitine for transport
type: Reaction

metaR PPItr
kinetic law: MODEL1310110012#
fast: false
type: Reaction
name: Diphosphate transporter, endoplasmic reticulum
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110012#
product: MODEL1310110012#
reversible: true

metaR STRDNCt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110012#
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110012#
is described by: ECO:0000000
fast: false
name: fatty acid transport via diffusion
kinetic law: MODEL1310110012#

metaR FACOAL40im
notes: GENE_ASSOCIATION: (116285.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: PMID:11470804,PMID:3297476 NOTES:JLR changed EC from 6.2.1.3 (long chain fatty-acyl CoA ligase) to 6.2.1.2 (butyrate-CoA ligase) - NCD
name: fatty-acid--CoA ligase (butanoate), mitochondrial
reactant: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
is described by: ECO:0000269
modifier: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.2
reversible: false

metaR GALASE12ly
kinetic law: MODEL1310110012#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110012#
reversible: false
modifier: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110012#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
type: Reaction

metaR AG13T4g
is: SBO:0000176
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110012#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false

metaM docoscoa x
boundary condition: false
constant: false
is: SBO:0000247
name: docosanoylcoa
is: HMDB12930
initial amount: NaN
notes: FORMULA: C43H74N7O17P3S CHARGE: -4
has only substance units: false
type: Species
initial concentration: 1.0

metaM arg L e
initial amount: NaN
constant: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: SBO:0000247
name: L-argininium(1+)
type: Species
initial concentration: 1.0
is: HMDB00517
boundary condition: false
is: CHEBI:32682
has only substance units: false

metaR GUAt
name: Guanine transport
type: Reaction
is described by: ECO:0000269
reversible: true
is: SBO:0000185
product: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR

metaM tdchola c
is: CHEBI:9407
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
name: taurochenodeoxycholate
initial amount: NaN
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
has only substance units: false
is: HMDB00951
constant: false

metaM tststerones e
is: HMDB02833
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: testosterone sulfate
has only substance units: false
type: Species
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1/C19H28O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h11,14-17H,3-10H2,1-2H3,(H,21,22,23)/t14-,15-,16-,17-,18-,19-/m0/s1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_5c8248e3_317b_412f_8021_9263d216b3c0
name: GPX5
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: O75715
is encoded by: hsa:2880
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_b7d9c8db_b3ee_4849_a260_f746e76237b3
is: SBO:0000252
is: G0W2N5
name: SLC14A1
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:6563
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_b175ef28_1797_4426_bcfc_71ab67cbd109
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:AL038231
name: _AL038231_1_c
is: SBO:0000252

metaR SADT
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.1.25
name: sulfate adenylyltransferase
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
reactant: MODEL1310110012#
fast: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reversible: false
modifier: MODEL1310110012#

metaM tsul e
is: CHEBI:16094
boundary condition: false
is: HMDB00257
is: SBO:0000247
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
has only substance units: false
initial amount: NaN
constant: false
name: thiosulfate(2-)
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_468c312a_a6cf_418d_bcce_b2934440fd8b
boundary condition: true
is encoded by: hsa:3295
is: SBO:0000297
constant: false
initial concentration: NaN
name: ACAA1:HSD17B4:ACOX1
type: Species
has part: E9PB82
has only substance units: false
initial amount: NaN

metaM hco3 m
is: SBO:0000247
name: Bicarbonate
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:17544
initial amount: NaN
constant: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: C00288
is: HMDB00595
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_420eac0f_04e0_4ccf_bb88_77894009f6f7
is: SBO:0000252
constant: false
type: Species
name: OTC
has only substance units: false
is encoded by: hsa:5009
is: P00480
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR RE3003M
name: RE3003
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.3.3.8
reversible: true
fast: false
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_64f573ca_500a_4530_8356_ba5908104d5b
name: PNMT
is: P11086
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5409
boundary condition: true
type: Species
constant: false
initial amount: NaN

metaR PROSTGF2t
reversible: true
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
fast: false
product: MODEL1310110012#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110012#
is described by: ECO:0000269
name: prostaglandin uniport

metaM ppcoa x
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
boundary condition: false
constant: false
is: HMDB01275
is: CHEBI:57392
is: SBO:0000247
name: Propanoyl-CoA
initial amount: NaN
is: C00100

metaM r5p r
type: Species
is: SBO:0000247
constant: false
is: CHEBI:18189
has only substance units: false
name: alpha-D-Ribose 5-phosphate
initial amount: NaN
is: HMDB00618
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
boundary condition: false
initial concentration: 1.0

metaR r0399
fast: false
kinetic law: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
reactant: MODEL1310110012#
is: SBO:0000176
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.2.4.2
product: MODEL1310110012#

metaR 4HGLSDm
type: Reaction
product: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.5.1.12
kinetic law: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000212
fast: false
modifier: MODEL1310110012#
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
reversible: true

metaR FAOXC3DC
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: malonylcoa-->malonylcarnitine
type: Reaction

metaR UMPK7n
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110012#
type: Reaction
is: SBO:0000176
name: UMP kinase (dGTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is described by: ECO:0000269
modifier: MODEL1310110012#
reversible: true
kinetic law: MODEL1310110012#

metaR r1625
fast: false
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110012#
is described by: ECO:0000000
reactant: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110012#

metaM ametam c
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137
is: CHEBI:57443
is: HMDB00988
constant: false
type: Species
is: C01137
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: S-Adenosylmethioninamine

http://identifiers.org/biomodels.db/MODEL1310110012#_cdf5c4a6_40c3_4e1b_aaae_053832b2e2c3
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:117248
name: GALNTL2
is: Q8N3T1
type: Species
is: SBO:0000252

metaM 34dhmald c
is: HMDB06242
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
is: C05577
is: http://identifiers.org/pubchem.compound/7903
name: 3,4-Dihydroxymandelaldehyde
constant: false
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
has only substance units: false

metaM hista e
has only substance units: false
is: HMDB00870
initial concentration: 1.0
initial amount: NaN
name: histamium
type: Species
boundary condition: false
is: CHEBI:58432
is: SBO:0000247
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
constant: false

metaM progly e
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB11178
type: Species
initial amount: NaN
constant: false
name: L-Prolinylglycine
notes: FORMULA: C7H12N2O3 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110012#_a256c199_97c4_4700_a5e5_35f211a566d1
name: PKM2
boundary condition: true
initial concentration: NaN
constant: false
is: P14618
type: Species
initial amount: NaN
is encoded by: hsa:5315
is: SBO:0000252
has only substance units: false

metaM acgal c
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
boundary condition: false
initial amount: NaN
is: CHEBI:28037
has only substance units: false
initial concentration: 1.0
name: N-acetyl-D-galactosamine
is: SBO:0000247
constant: false
is: HMDB00212

metaR NDP8
modifier: MODEL1310110012#
is described by: ECO:0000269
reactant: MODEL1310110012#
is: SBO:0000176
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
reversible: false
product: MODEL1310110012#
type: Reaction
name: nucleoside-diphosphatase (dUDP)
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.9

metaM cs a deg3 l
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C31H48NO32S2 CHARGE: -3
initial amount: NaN
initial concentration: 1.0
is: HMDB00127
type: Species
is: CHEBI:15748

metaR r1624
modifier: MODEL1310110012#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110012#
fast: false

metaR r2037
reversible: false
product: MODEL1310110012#
modifier: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR PCHOL HStg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
reversible: true
name: phosphatidylcholine scramblase
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110012#

metaR ASNCYSNaEx
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
type: Reaction
modifier: MODEL1310110012#
reversible: false
is: SBO:0000185
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

http://identifiers.org/biomodels.db/MODEL1310110012#_449745d5_0129_456e_8da8_9fcbdc2d45ad
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9551
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is: P56134
name: ATP5J2

metaR PPItm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
name: diphopshate transporter, mitochondrial
fast: false
product: MODEL1310110012#
reversible: true
reactant: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110012#_d3ce5c7b_7d58_44fd_a38c_6e65b903376c
type: Species
has only substance units: false
name: PDE3B
is: A7E2E5
boundary condition: true
constant: false
is encoded by: hsa:5140
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR GHMT2rm
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.1.2.1
fast: false
kinetic law: MODEL1310110012#
is: SBO:0000176
name: glycine hydroxymethyltransferase, reversible, mitochondrial
type: Reaction
modifier: MODEL1310110012#
reactant: MODEL1310110012#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110012#_af8c1e8d_29c1_47e7_a6d3_c936cf16f662
name: HAL
type: Species
has only substance units: false
initial concentration: NaN
is: B4E0V8
constant: false
is encoded by: hsa:3034
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR r1623
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110012#
kinetic law: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110012#
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110012#
is: SBO:0000185
type: Reaction

metaR S6TASE17ly
reactant: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
fast: false
reversible: true
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.1.6.14

http://identifiers.org/biomodels.db/MODEL1310110012#_a409315b_ae3d_411c_ae74_d1fc738a45d9
constant: false
type: Species
is: SBO:0000252
name: PPA1
is encoded by: hsa:5464
initial amount: NaN
boundary condition: true
is: Q15181
initial concentration: NaN
has only substance units: false

metaM pre prot r
is: SBO:0000247
is: CHEBI:16240
initial amount: NaN
initial concentration: 1.0
name: glycophosphatidylinositol (GPI)-anchored protein precursor
constant: false
type: Species
is: HMDB03125
notes: FORMULA: XY CHARGE: 0
boundary condition: false
has only substance units: false

metaR CMPSAS
type: Reaction
is described by: ECO:0000304
name: CMP sialic acid synthase
reversible: false
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
kinetic law: MODEL1310110012#
fast: false
is: SBO:0000176
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.7.43
reactant: MODEL1310110012#

metaM hista c
constant: false
initial concentration: 1.0
name: histamium
is: HMDB00870
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:58432
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: SBO:0000247
has only substance units: false

metaR HCO3 NAt
is: SBO:0000185
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (9497.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10993873,PMID:14722772 NOTES:MM
kinetic law: MODEL1310110012#
name: bicarbonate transport (Na/HCO3 cotransport)
product: MODEL1310110012#
modifier: MODEL1310110012#
reversible: true
type: Reaction
is described by: ECO:0000006
fast: false

metaR C121CPT1
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecenoylcarnitine
type: Reaction

metaR GAL3ST11
reversible: false
type: Reaction
kinetic law: MODEL1310110012#
is: SBO:0000176
name: Galactosylceramide sulfotransferase
product: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
reactant: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.11

metaM c12dc x
is: HMDB11123
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
name: dodecanedioyl carnitine
has only substance units: false
boundary condition: false
notes: FORMULA: C19H34NO6 CHARGE: -1
is: C05279
initial amount: NaN

metaM thm c
is: C00378
notes: FORMULA: C12H17N4OS CHARGE: 1
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:0
name: Thiamin
is: HMDB00235
constant: false
boundary condition: false
type: Species
has only substance units: false

metaM progly c
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB11178
notes: FORMULA: C7H12N2O3 CHARGE: 0
name: L-Prolinylglycine
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_a7567f56_93bb_4a35_9b4f_46b5114785da
type: Species
is: SBO:0000252
is encoded by: hsa:4705
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: O95299
name: NDUFA10
initial amount: NaN

metaM nadp m
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:58349
is: C00006
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
name: Nicotinamide adenine dinucleotide phosphate
is: HMDB00217
is: SBO:0000247

metaR r2405
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
fast: false
is described by: ECO:0000000
reactant: MODEL1310110012#
is: SBO:0000185
kinetic law: MODEL1310110012#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110012#_c93a9f1e_d4fe_48d7_b269_afcd699f68cb
is encoded by: hsa:224
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P51648
type: Species
constant: false
initial concentration: NaN
name: ALDH3A2
initial amount: NaN

metaR NACHEX25ly
is: SBO:0000176
modifier: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110012#
fast: false
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false

metaR ALATHRNaEx
reactant: MODEL1310110012#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110012#
is: SBO:0000185
name: L-alanine/L-threonine Na-dependent exchange (Ala-L in)
fast: false
reversible: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
type: Reaction

metaR URIt5le
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: uridine transport in via sodium symport (1:2)
fast: false
product: MODEL1310110012#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110012#
modifier: MODEL1310110012#
reversible: false
kinetic law: MODEL1310110012#
is described by: ECO:0000134

metaR r1622
reactant: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110012#
is: SBO:0000185
kinetic law: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110012#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_4b138eb4_8c1b_4e7b_8a4e_5926f8ddfb52
is: Q9UF12
initial concentration: NaN
type: Species
name: PRODH2
constant: false
boundary condition: true
is encoded by: hsa:58510
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_e8e29708_44ae_4e26_a8b6_ff1367c3766b
name: INPP5A
initial concentration: NaN
has only substance units: false
constant: false
is: Q14642
type: Species
boundary condition: true
is encoded by: hsa:3632
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_bfd99263_bf02_4cfe_9551_bb93744a52be
initial amount: NaN
has only substance units: false
is encoded by: hsa:9187
is: B4DUG1
constant: false
is: SBO:0000252
name: SLC24A1
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_11778850_1989_4103_a639_5e1e36e280d4
is: P30048
name: PRDX3
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:10935
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

metaR FAOXC226205x
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
is: SBO:0000176
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
modifier: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_3e7cf823_6d6b_4274_882d_bcd3ecdd248d
is encoded by: hsa:30833
name: NT5C
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
is: Q8TCD5
initial amount: NaN
type: Species
initial concentration: NaN

metaM g3m8masn r
has only substance units: false
initial amount: NaN
notes: FORMULA: C88H147N2O70X CHARGE: 0
type: Species
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
is: C05873

metaR EX aprgstrn LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 20alpha-Hydroxyprogesterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_7939b0ea_d04e_4b8a_84f6_8fe58716719b
is encoded by: hsa:2645
is: SBO:0000252
constant: false
has only substance units: false
name: GCK
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_3c255c55_3a44_4c2f_bdd8_924a03285248
has only substance units: false
is: Q9H008
type: Species
is encoded by: hsa:64077
constant: false
is: SBO:0000252
name: LHPP
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR CYTK7n
reversible: true
reactant: MODEL1310110012#
modifier: MODEL1310110012#
name: cytidylate kinase (CMP,UTP),nuclear
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110012#
fast: false
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_32396353_d6bf_4a0e_ae81_704c268c555d
boundary condition: true
is: P53602
initial concentration: NaN
name: MVD
is encoded by: hsa:4597
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species

metaR r1629
is described by: ECO:0000000
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR NRPPHRt4 2 r
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Norepinephrine reversible transport in via sodium symport (1:2)
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
is described by: ECO:0000269

metaR r0822
reactant: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
product: MODEL1310110012#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185
kinetic law: MODEL1310110012#
is described by: ECO:0000000
type: Reaction
reversible: true
modifier: MODEL1310110012#

metaM 3sala c
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
type: Species
initial amount: NaN
has only substance units: false
is: C00606
boundary condition: false
initial concentration: 1.0
name: 3-Sulfino-L-alanine
is: CHEBI:61085
is: SBO:0000247
constant: false

metaR ST8SIA12
name: Beta-galactoside alpha-2,3-sialyltransferase
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.99.8
reactant: MODEL1310110012#
reversible: false
type: Reaction
product: MODEL1310110012#
is described by: ECO:0000000
kinetic law: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_7c655b97_3716_440d_b7c1_d4704b62e39c
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8654
initial amount: NaN
constant: false
name: PDE5A

http://identifiers.org/biomodels.db/MODEL1310110012#_c9fa4425_ee4b_467b_bb42_1b3fa4641e12
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: GCNT4
is encoded by: hsa:51301
has only substance units: false
constant: false
is: Q9P109
initial amount: NaN
type: Species

metaM ksi pre16 g
name: keratan sulfate I biosynthesis, precursor 16
is: HMDB00175
initial amount: NaN
constant: false
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
is: C00130
has only substance units: false
is: CHEBI:58053
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species

W3 CDTF: Thu Aug 30 12:47:51 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110012#_d8fd26b6_b915_4f97_83b1_9be682df1a9e
initial amount: NaN
name: MYO5B
constant: false
has only substance units: false
is: Q9H6Y6
is: SBO:0000252
is encoded by: hsa:4645
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_e182023a_7e6c_4867_8018_f307ad4ffc87
is encoded by: hsa:6392
is: O14521
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: SDHD
type: Species

metaR RE3074X
notes: GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:11060359,PMID:11356164 NOTES:IT - fixed proton
modifier: MODEL1310110012#
fast: false
is: SBO:0000176
name: RE3074
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
reactant: MODEL1310110012#
reversible: true
product: MODEL1310110012#
kinetic law: MODEL1310110012#

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_cb945cd8_8be4_4ec4_82c8_4a5fd8909701
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: SLC17A1
constant: false
initial concentration: NaN
is: Q14916
is encoded by: hsa:6568
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_6720dc22_70fc_43ff_9744_1a1e16cdce0e
is: SBO:0000252
is: Q9BQL0
type: Species
name: BCKDHB
initial amount: NaN
is encoded by: hsa:594
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN

metaR r1774
product: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
name: Y+LAT2 Utilized transport
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM hdca r
initial amount: NaN
is: SBO:0000247
is: C00249
type: Species
constant: false
name: Hexadecanoate (n-C16:0)
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: HMDB00220
is: CHEBI:7896

metaR CSPG Etly
reactant: MODEL1310110012#
is described by: ECO:0000000
name: chondroitin sulfate E transport, extracellular to lysosome
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110012#
type: Reaction
reversible: false
is: SBO:0000185
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_ac954ef8_1e1c_4762_9000_c8302b4b629c
is encoded by: hsa:52
is: SBO:0000252
type: Species
is: B5MCC7
name: ACP1
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false

metaM hs deg8 l
is: SBO:0000247
initial concentration: 1.0
name: heparan sulfate, degradation product 8
type: Species
constant: false
is: CHEBI:16126
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
boundary condition: false
initial amount: NaN
has only substance units: false

metaR FATP8t
product: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/6.2.1.7
is: SBO:0000185
type: Reaction
fast: false
name: fatty acid electroneutral transport
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110012#

metaR EX 3ddcrn
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

metaR LNELDCCPT2
reactant: MODEL1310110012#
reversible: false
fast: false
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110012#
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_171eb916_a852_4e50_9133_eb286338987a
is: Q14442
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5283
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: PIGH

metaM pram c
name: 5-Phospho-beta-D-ribosylamine
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
is: HMDB01128
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:58681
is: C03090
is: SBO:0000247
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_289c93bd_8e97_4435_9d6c_ba837bea2597
constant: false
is: SBO:0000252
boundary condition: true
is: Q92569
type: Species
initial concentration: NaN
initial amount: NaN
name: PIK3R3
is encoded by: hsa:8503
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_b17fab1e_275f_4b69_af44_835eb1554164
is encoded by: hsa:11001
constant: false
initial amount: NaN
is: O14975
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
name: SLC27A2

W3 CDTF: Thu Aug 30 12:47:51 BST 2012

metaR r1628
reactant: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110012#
reversible: true
product: MODEL1310110012#

metaM gam6p c
type: Species
name: D-Glucosamine 6-phosphate
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
is: HMDB01254
is: CHEBI:12962

metaR RE2972M
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000176
type: Reaction
name: RE2972
is described by: ECO:0000000
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.67
modifier: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:

metaM arg L m
is: HMDB00517
constant: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
type: Species
name: L-argininium(1+)
boundary condition: false
is: CHEBI:32682
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR C4CRNCPT2
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of butyryl carnitine in the mitochondrial matrix for final hydrolysis
type: Reaction

metaR FAOXC142C142OHm
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C14:2OH)m
type: Reaction

metaM ura c
is: HMDB00300
type: Species
initial concentration: 1.0
initial amount: NaN
name: Uracil
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
has only substance units: false
is: CHEBI:17568
boundary condition: false
is: SBO:0000247
constant: false
is: C00106

metaR ACOAD10m
kinetic law: MODEL1310110012#
is described by: ECO:0000269
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
product: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
type: Reaction
reversible: false
reactant: MODEL1310110012#

metaR ACNAMlt
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110012#
fast: false
name: N-acetylneuraminate transport into lysososme
reactant: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000185
modifier: MODEL1310110012#
reversible: true

metaM acgal g
is: HMDB00212
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
initial concentration: 1.0
is: CHEBI:28037
name: N-acetyl-D-galactosamine

metaM cdpea c
name: cdpea[c]
is: HMDB01564
boundary condition: false
notes: FORMULA: C11H19N4O11P2 CHARGE: -1 INCHI: InChI=1S/C11H20N4O11P2/c12-2-4-23-27(19,20)26-28(21,22)24-5-6-8(16)9(17)10(25-6)15-3-1-7(13)14-11(15)18/h1,3,6,8-10,16-17H,2,4-5,12H2,(H,19,20)(H,21,22)(H2,13,14,18)/p-1/t6-,8-,9-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00433 EHMN_ABBREVIATION: C00570
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: CHEBI:57876
has only substance units: false

metaR LNELDCCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110012#
type: Reaction
name: carnitine O-palmitoyltransferase
is: SBO:0000176
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reversible: false
fast: false
reactant: MODEL1310110012#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

metaR CLPNDCOAtx
product: MODEL1310110012#
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
kinetic law: MODEL1310110012#
name: fatty acid intracellular transport
reactant: MODEL1310110012#
is described by: ECO:0000000

metaR DM fol
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

metaM 4hglusa m
name: L-4-hydroxyglutamic semialdehyde
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
type: Species
is: CHEBI:27809
is: HMDB06556
initial amount: NaN
constant: false
has only substance units: false

metaR PTRCOX1
product: MODEL1310110012#
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.22
is described by: ECO:0000304
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.21
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:9119395 NOTES:SAB
reactant: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#
name: Putrescine:oxygen oxidoreductase (deaminating)

metaR r1627
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110012#
type: Reaction
fast: false

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_98ae4fc5_2da9_430e_9543_984fa583b30d
type: Species
name: NDUFB10
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: A8K761
is encoded by: hsa:4716
initial amount: NaN
constant: false

metaR TYR3MO2
product: MODEL1310110012#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7054.1) or (7054.3) or (7054.2) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.16.2 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9920892 NOTES:SAB unlumped form based on PMID 10727395
kinetic law: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
type: Reaction
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.14.16.2
name: tyrosine 3-monooxygenase
reversible: false
is: SBO:0000176

metaM dec47dicoa x
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/16019966
constant: false
name: 4,7-decadienoylcoa

metaR FAS160COA
modifier: MODEL1310110012#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110012#
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
product: MODEL1310110012#
name: fatty-acyl-CoA synthase (n-C16:0CoA)
reactant: MODEL1310110012#

metaR FAOXC102C81m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

metaR r0821
reversible: true
product: MODEL1310110012#
is: SBO:0000185
reactant: MODEL1310110012#
is described by: ECO:0000000
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_c084cd1d_c222_4f11_bbc9_376d1b06d222
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
name: PCBD1
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5092
type: Species

metaM didp n
name: dIDP
is: CHEBI:28823
initial concentration: 1.0
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
is: HMDB03536
type: Species
has only substance units: false

metaR r1903
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reversible: false
reactant: MODEL1310110012#
is: SBO:0000185
modifier: MODEL1310110012#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110012#_ef63934c_0af3_4dc2_8307_5a4737c49829
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: _AI697028_1_e
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI697028

metaM 10fthf7glu e
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C50H57N13O25 CHARGE: -8
is: HMDB00972
is: CHEBI:57454
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
name: 10-formyltetrahydrofolate-[Glu](7)

W3 CDTF: Thu Aug 30 12:47:51 BST 2012

metaR r1626
reactant: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110012#
type: Reaction
modifier: MODEL1310110012#
reversible: true
product: MODEL1310110012#

metaR ST8SIA11
reversible: false
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
product: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
type: Reaction
is described by: ECO:0000000
name: Beta-galactoside alpha-2,3-sialyltransferase
is version of: http://identifiers.org/ec-code/2.4.99.8

metaR FACOAL191
type: Reaction
fast: false
reactant: MODEL1310110012#
name: fatty-acid--CoA ligase
product: MODEL1310110012#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:11591435 NOTES:current models suggest COAL activity occurs on outer peroxisomal membrane NJ

metaM hs deg4 l
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
is: SBO:0000247
initial amount: NaN
type: Species
name: heparan sulfate, degradation product 4
has only substance units: false
is: CHEBI:16126
constant: false
initial concentration: 1.0
boundary condition: false

metaM ura e
type: Species
initial amount: NaN
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
initial concentration: 1.0
is: CHEBI:17568
is: SBO:0000247
name: uracil
constant: false
boundary condition: false
is: HMDB00300
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_70b4155f_a5c2_46ff_85a6_830101757f37
is encoded by: hsa:51
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: ACOX1
is: B4DK61
initial amount: NaN

metaM etfrd m
initial amount: NaN
has only substance units: false
is: CHEBI:17263
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
is: HMDB00145
boundary condition: false
notes: FORMULA: RH2 CHARGE: 0
name: Electron transfer flavoprotein reduced

metaM lpam m
name: lipoamide
is: SBO:0000247
initial amount: NaN
is: HMDB00962
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
is: CHEBI:17460

metaR FAOXC12DCx
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanedioyl carnitine
type: Reaction

metaM xoltriol m
type: Species
boundary condition: false
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
is: CHEBI:16496
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB01457
has only substance units: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454

metaR AG13T2g
is described by: ECO:0000000
modifier: MODEL1310110012#
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110012#
product: MODEL1310110012#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
type: Reaction

metaM ksii core4 pre3 g
has only substance units: false
is: C00130
type: Species
notes: FORMULA: C55H89N5O38X CHARGE: -1
name: keratan sulfate II biosynthesis, precursor 3
is: CHEBI:58053
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00175

metaM acgal l
is: SBO:0000247
is: HMDB00212
boundary condition: false
name: N-acetyl-D-galactosamine
initial amount: NaN
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
initial concentration: 1.0
constant: false
is: CHEBI:28037
has only substance units: false
type: Species

metaR EX lgnc LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lignoceric acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_4691b68d_3c3a_438a_bf12_33f9038b3060
type: Species
is: P17858
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5211
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
name: PFKL

http://identifiers.org/biomodels.db/MODEL1310110012#_90c31b62_c081_4e63_9453_113a36a63921
is encoded by: hsa:7054
is: SBO:0000252
type: Species
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: TH

metaR KHK
is described by: ECO:0000000
reactant: MODEL1310110012#
name: ketohexokinase
kinetic law: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.3
is: SBO:0000176

metaR PPItx
name: Diphosphate transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
type: Reaction
is described by: ECO:0000000
product: MODEL1310110012#
reversible: true
fast: false
kinetic law: MODEL1310110012#
is: SBO:0000185
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_d43b0060_13a2_47ce_b829_40b4e9b0c044
type: Species
is: P21953
is: SBO:0000252
is encoded by: hsa:594
constant: false
initial concentration: NaN
initial amount: NaN
name: BCKDHB
boundary condition: true
has only substance units: false

metaR r0391
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
fast: false
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
reactant: MODEL1310110012#
is: SBO:0000176
product: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
reversible: true

metaR SO4tl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110012#
name: Sulfate transport (lysosome)
fast: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
is: SBO:0000185

metaM 3hexdcrn c
notes: FORMULA: C23H45NO5 CHARGE: 0
is: SBO:0000247
name: 3-hydroxyhexadecanoylcarnitine
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB13336

metaM tsul c
constant: false
is: HMDB00257
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:16094
name: thiosulfate(2-)
initial concentration: 1.0
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
has only substance units: false
boundary condition: false

metaR ILEtec
reversible: true
product: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000269
is: SBO:0000185
name: L-isoleucine transport via diffusion (extracellular to cytosol)
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reactant: MODEL1310110012#
type: Reaction
fast: false
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_6a2fb28c_02b5_4915_9df5_1d4b9734c19d
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:4125
is: O00754
constant: false
type: Species
initial concentration: NaN
name: MAN2B1

metaM nadp c
is: C00006
initial concentration: 1.0
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
name: Nicotinamide adenine dinucleotide phosphate
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: HMDB00217
is: SBO:0000247
is: CHEBI:58349

metaR RE3421R
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
reactant: MODEL1310110012#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
product: MODEL1310110012#
name: RE3421
kinetic law: MODEL1310110012#
reversible: true

metaM hpdcacrn m
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
name: heptadecanoyl carnitine
has only substance units: false
is: HMDB06210
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_e4e2f663_2416_49a0_9b5b_616ecd359aac
name: _FLJ44968_1_m
initial concentration: NaN
is encoded by: hsa:FLJ44968
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_61ea8de4_26e6_4fa8_80d1_ab65b551e0af
boundary condition: true
is encoded by: hsa:2629
has only substance units: false
name: GBA
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252

metaM 3mgcoa m
is: HMDB01057
constant: false
is: CHEBI:57346
boundary condition: false
initial concentration: 1.0
name: trans-3-methylglutaconyl-CoA(5-)
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
initial amount: NaN

metaM cs e deg6 l
boundary condition: false
has only substance units: false
is: CHEBI:16953
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6
notes: FORMULA: C31H48NO32S2 CHARGE: -3
initial concentration: 1.0
is: HMDB00812
type: Species
initial amount: NaN
is: SBO:0000247
constant: false

metaR FUCASE2e
modifier: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000000
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:10460218,PMID:11389735,PMID:12604617,PMID:2317201 NOTES:NCD
fast: false
reversible: false
kinetic law: MODEL1310110012#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.51
name: alpha-fucosidase, extracellular

metaR r0392
product: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is: SBO:0000176
reversible: true
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110012#_ba8da644_c3bb_4faa_817d_4a99a2b7571f
initial amount: NaN
is encoded by: hsa:4594
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: P22033
name: MUT

metaR C14STRr
name: C-14 sterol reductase
is version of: http://identifiers.org/ec-code/1.3.1.70
reactant: MODEL1310110012#
is described by: ECO:0000134
type: Reaction
reversible: false
kinetic law: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
fast: false
modifier: MODEL1310110012#
product: MODEL1310110012#

metaM 3tdcrn e
boundary condition: false
has only substance units: false
constant: false
is: HMDB13336
initial amount: NaN
name: 3-hydroxy-tetradecanoyl carnitine
notes: FORMULA: C21H41NO5 CHARGE: 0
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR ALAGLNNaEx
fast: false
product: MODEL1310110012#
reversible: false
reactant: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
name: L-alanine/L-glutamine Na-dependent exchange (Ala-L in)
modifier: MODEL1310110012#
is described by: ECO:0000269

metaM 2mb2coa c
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB02054
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
name: 2-methylcrotonoyl-CoA(4-)

W3 CDTF: Thu Aug 30 12:47:51 BST 2012

metaR S3TASE3ly
is: SBO:0000176
name: N-acetylglucosamine-3-sulfatase, lysosomal
reactant: MODEL1310110012#
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
product: MODEL1310110012#

metaR FDH
type: Reaction
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.5.1.6
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110012#
name: formate dehydrogenase
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (10840.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.2.1.2 Confidence Level: 2 AUTHORS: NOTES:

metaR TKT2
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.2.1.1
product: MODEL1310110012#
name: transketolase
fast: false
is: SBO:0000176
reversible: true
modifier: MODEL1310110012#
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_1e4a487a_48ac_45ed_abfd_39172677c8d0
is: P48651
type: Species
constant: false
is encoded by: hsa:9791
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: PTDSS1

metaM ksii core2 deg9 l
notes: FORMULA: C30H50N3O20X CHARGE: 0
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 9
has only substance units: false
is: SBO:0000247
is: CHEBI:12936
constant: false
type: Species
is: HMDB00143

metaR FACOAL245 2
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
modifier: MODEL1310110012#
name: fatty-acid--CoA ligase
product: MODEL1310110012#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000176

metaM dgsn c
name: Deoxyguanosine
initial concentration: 1.0
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
boundary condition: false
constant: false
is: HMDB00085
is: SBO:0000247
has only substance units: false
type: Species
is: C00330
initial amount: NaN
is: CHEBI:17172

http://identifiers.org/biomodels.db/MODEL1310110012#_78fecb67_e488_4eed_b3d8_329382338666
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
name: DGUOK
is encoded by: hsa:1716
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_3c17a19b_78e2_43ec_a647_246f69bc54bc
is: SBO:0000252
is encoded by: hsa:50700
is: Q9NYR8
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
name: RDH8
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_b85952ee_50b6_430b_9133_ff8a77d488a2
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:2184
boundary condition: true
name: FAH
type: Species
is: P16930

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

metaR r0393
product: MODEL1310110012#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
reactant: MODEL1310110012#
is: SBO:0000176
reversible: false
type: Reaction
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.74

metaR r1907
is: SBO:0000185
reactant: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
modifier: MODEL1310110012#
is described by: ECO:0000000
kinetic law: MODEL1310110012#
type: Reaction
reversible: false
product: MODEL1310110012#

metaR EX CE5867 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acetyl-seryl-aspartyl-lysyl-proline exchange
type: Reaction

metaM 3hexdcrn e
notes: FORMULA: C23H45NO5 CHARGE: 0
constant: false
name: 3-hydroxyhexadecanoylcarnitine
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB13336
has only substance units: false
is: SBO:0000247

metaR TKT1
product: MODEL1310110012#
is: SBO:0000176
reversible: true
modifier: MODEL1310110012#
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is version of: http://identifiers.org/ec-code/2.2.1.1
name: transketolase

metaM f26bp c
is: HMDB01047
is: CHEBI:58579
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-2-6(18-20(13,14)15)5(9)4(8)3(17-6)1-16-19(10,11)12/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4-,5+,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00484 EHMN_ABBREVIATION: C00665
is: SBO:0000247
name: beta-D-fructofuranose 2,6-bisphosphate(4-)
type: Species

metaR FACOAL245 1
type: Reaction
reactant: MODEL1310110012#
is described by: ECO:0000000
name: fatty-acid--CoA ligase
product: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
modifier: MODEL1310110012#
reversible: true

metaR RE3273C
fast: false
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.4.4
reactant: MODEL1310110012#
type: Reaction
name: RE3273
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
product: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000176

metaM dgmp e
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57673
name: dGMP(2-)
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
type: Species
has only substance units: false
is: HMDB01044
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_aab83596_261f_415a_80fe_1db332ff54ee
constant: false
name: GBA
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:2629

http://identifiers.org/biomodels.db/MODEL1310110012#_01bee84c_e63d_4e0a_a2a9_2fe60df2c354
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is: Q06278
name: AOX1
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:316

metaR r0394
reactant: MODEL1310110012#
product: MODEL1310110012#
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
fast: false
kinetic law: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true

metaR DHORD9
reactant: MODEL1310110012#
is: SBO:0000185
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.3.5.2
type: Reaction
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110012#
name: dihydoorotic acid dehydrogenase (quinone10)
fast: false

metaM HC01602 c
is: C00234
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57454
constant: false
initial amount: NaN
name: 10-Formyltetrahydrofolate
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
has only substance units: false
type: Species

metaR PCHOLPm hs
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.1.4.4
fast: false
type: Reaction
reversible: false
name: choline phosphatase
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000176
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_06af68f7_72a5_42ac_8fe4_95f7ea74f94b
type: Species
is: Q06203
initial concentration: NaN
name: PPAT
boundary condition: true
constant: false
is encoded by: hsa:5471
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR C101CRNe
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decenoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_387eee73_d2d2_44a7_9892_dff82d7946a7
is: Q9UNK4
name: PLA2G2D
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:26279

http://identifiers.org/biomodels.db/MODEL1310110012#_5687199a_2335_4395_90a6_c41f1bf9697a
initial concentration: NaN
is encoded by: hsa:4905
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: P46459
name: NSF
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_eeeef720_6da2_4f1b_8a54_5841982d7b03
is encoded by: hsa:AA532636
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
name: _AA532636_1_m

metaR SIAASE2ly
product: MODEL1310110012#
modifier: MODEL1310110012#
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
fast: false
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
is: SBO:0000176

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaR ABTD
reactant: MODEL1310110012#
reversible: true
is described by: ECO:0000000
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
name: L-arabinitol 4-dehydrogenase
is: SBO:0000176
fast: false
kinetic law: MODEL1310110012#
type: Reaction

metaR FAOXC12DCc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: formation of dodecanedioyl carnitine
type: Reaction

metaM n2m2masn g
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: C11530
constant: false
type: Species
notes: FORMULA: C50H83N4O35X CHARGE: 0
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaM dsmsterol r
type: Species
has only substance units: false
is: HMDB02719
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
is: CHEBI:17737
constant: false
is: SBO:0000247
initial amount: NaN
name: desmosterol

metaR ACGAMK
reactant: MODEL1310110012#
type: Reaction
reversible: false
is described by: ECO:0000269
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
name: N-acetylglucosamine kinase
modifier: MODEL1310110012#
is: SBO:0000176
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.1.59
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_46a32eb4_8839_4cc4_9a7c_276d784478a6
initial concentration: NaN
is: Q96RV2
type: Species
initial amount: NaN
is encoded by: hsa:3038
has only substance units: false
boundary condition: true
constant: false
name: HAS3
is: SBO:0000252

metaR r0819
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
product: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185
reversible: true

metaM HC01223 m
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57340
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_6648028b_6c79_4940_8f0d_4231a20cd4c2
type: Species
is encoded by: hsa:6817
constant: false
has only substance units: false
initial amount: NaN
name: SULT1A1
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_ce2e950c_26e2_40e2_8a43_892bc22b0d5f
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:6519
initial concentration: NaN
name: SLC3A1
initial amount: NaN
type: Species
is: SBO:0000252
is: Q07837

metaR r0242
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
kinetic law: MODEL1310110012#
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110012#
fast: false
product: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/6.2.1.1
is described by: ECO:0000000
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1

http://identifiers.org/biomodels.db/MODEL1310110012#_21cb37dd_db39_4496_aa54_d25e1dbac847
constant: false
is encoded by: hsa:10606
is: P22234
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: PAICS
initial amount: NaN
has only substance units: false

metaR EX taxol LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: paclitaxel exchange
type: Reaction

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

metaM ppcoa c
is: HMDB01275
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
name: Propanoyl-CoA
is: CHEBI:57392
is: SBO:0000247
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
has only substance units: false
constant: false
is: C00100

metaR EX Tyr ggn LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyr-194 of apo-glycogenin protein (primer for glycogen synthesis) exchange
type: Reaction

metaR r0545
type: Reaction
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
is: SBO:0000176
kinetic law: MODEL1310110012#
is described by: ECO:0000000
product: MODEL1310110012#
modifier: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
reactant: MODEL1310110012#

metaM dopasf c
is: CHEBI:37946
has only substance units: false
is: HMDB06275
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
name: dopamine 3-O-sulfate
type: Species
boundary condition: false
is: SBO:0000247
constant: false

metaM 25aics c
is: CHEBI:58443
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
is: C04823
has only substance units: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
is: HMDB00797
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_b6560282_ddca_4972_b138_e2d7eb2d0aab
boundary condition: true
constant: false
name: SLC4A5
is encoded by: hsa:57835
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN

metaM ile L m
name: L-isoleucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00172
is: CHEBI:17191
boundary condition: false

metaM ksii core2 pre6 g
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
name: keratan sulfate II biosynthesis, precursor 6
has only substance units: false
notes: FORMULA: C61H98N5O46SX CHARGE: -2
boundary condition: false
is: CHEBI:28067

metaR r0245
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176
reversible: true
is described by: ECO:0000000
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
type: Reaction

metaR CORE2GTg
fast: false
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.102
kinetic law: MODEL1310110012#

metaM 3ddecdicoa x
initial amount: NaN
boundary condition: false
is: HMDB03952
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: 3,6-dodecadienoylcoa
constant: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: C05280

metaM r5p c
is: SBO:0000247
initial amount: NaN
is: CHEBI:18189
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: alpha-D-Ribose 5-phosphate
type: Species
is: HMDB00618
is: C00117
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117

metaM ksi deg23 l
initial concentration: 1.0
has only substance units: false
name: keratan sulfate I, degradation product 23
boundary condition: false
is: CHEBI:12936
is: HMDB00143
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C124H201N8O106S5 CHARGE: -5

metaR DHFR
reversible: true
name: dihydrofolate reductase
modifier: MODEL1310110012#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3
type: Reaction
is described by: ECO:0000254
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
fast: false

metaR r0817
reversible: true
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
product: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.41
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
fast: false
modifier: MODEL1310110012#
is: SBO:0000185

metaR EX c10crn
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decanoyl carnitine
type: Reaction

metaR FAOXC16C16OHm
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C16OH)m
type: Reaction

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaM Rtotal2 e
initial concentration: 1.0
name: R total 2 position
is: SBO:0000247
type: Species
is: C00255
boundary condition: false
constant: false
has only substance units: false
is: HMDB00244
is: CHEBI:3554
initial amount: NaN
notes: FORMULA: CO2FULLR2 CHARGE: -1

metaR FUMSO3tm
type: Reaction
product: MODEL1310110012#
is described by: ECO:0000269
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reactant: MODEL1310110012#
reversible: true
kinetic law: MODEL1310110012#
is: SBO:0000185
fast: false
name: Fumarate:sulfite antiport, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110012#_bb784eb0_48c7_43e4_bcec_4186704086f0
is: O60488
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: ACSL4
is encoded by: hsa:2182
initial concentration: NaN
boundary condition: true
constant: false
type: Species

metaR ITCOALm
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176
is described by: ECO:0000212
type: Reaction
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
fast: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/6.2.1.5
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
reactant: MODEL1310110012#

metaR TETPENT6t
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
product: MODEL1310110012#
is: SBO:0000185
name: fatty acid transport via diffusion
reactant: MODEL1310110012#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_597b9e2b_ac50_4487_bd02_a27066bd366b
boundary condition: true
is: SBO:0000252
name: PGK1
initial amount: NaN
type: Species
constant: false
is: P00558
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5230

http://identifiers.org/biomodels.db/MODEL1310110012#_8d069eec_ae55_462f_a388_83169ba578d5
name: IDUA
is: P35475
is encoded by: hsa:3425
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: NaN

metaR r0547
name: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5
is: SBO:0000176
fast: false
product: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
is version of: http://identifiers.org/ec-code/1.17.1.4
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction

metaM dopasf e
is: CHEBI:37946
initial amount: NaN
is: HMDB06275
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
type: Species
name: dopamine 3-O-sulfate
is: SBO:0000247
constant: false
boundary condition: false

metaR CYSGLNNaEx
product: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
modifier: MODEL1310110012#
reversible: false
is: SBO:0000185
type: Reaction
name: L-cysteine/L-glutamine Na-dependent exchange (Cys-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_62327b97_67de_45b4_af04_531a2a70f382
boundary condition: true
is: Q16877
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5210
name: PFKFB4
constant: false
is: SBO:0000252
initial amount: NaN
type: Species

metaR FAOXC226205m
modifier: MODEL1310110012#
product: MODEL1310110012#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
kinetic law: MODEL1310110012#
type: Reaction
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110012#_9ac44a1c_b751_427e_80d0_85db2ac20cd2
initial concentration: NaN
is: Q9Y2P5
constant: false
boundary condition: true
is encoded by: hsa:10998
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: SLC27A5
type: Species

metaM 2hexdtricoa x
is: HMDB02288
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: SBO:0000247
name: 2,7,10-hexadecatrienoylcoa
initial amount: NaN
boundary condition: false
has only substance units: false

metaR LEUtec
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
name: L-leucine transport via diffusion (extracellular to cytosol)
product: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110012#
type: Reaction
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_12188289_09f5_4592_a995_855a9ecef085
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:9583
is: Q9Y227
name: ENTPD4
type: Species
has only substance units: false
constant: false

metaR VITD3t2
is described by: ECO:0000000
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
fast: false
product: MODEL1310110012#
reversible: false
type: Reaction
name: Vitamin D3 uptake
is: SBO:0000185

metaM glyc c
is: HMDB00131
boundary condition: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: C00116
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
name: Glycerol
initial concentration: 1.0
is: CHEBI:17754

http://identifiers.org/biomodels.db/MODEL1310110012#_0ba16874_efa7_46d5_988f_0d2d5d135e12
constant: false
is encoded by: hsa:10786
has only substance units: false
type: Species
name: SLC17A3
boundary condition: true
initial concentration: NaN
is: O00476
is: SBO:0000252
initial amount: NaN

metaM 2octpencoa m
is: http://identifiers.org/pubchem.compound/5280355
type: Species
boundary condition: false
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
name: 2,6,9,12,15-octadecapentenoylcoa
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR L LACt4r
product: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
name: L-lactate reversible transport via sodium symport
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false

metaR LNLNCACRNt
kinetic law: MODEL1310110012#
is: SBO:0000185
fast: false
reactant: MODEL1310110012#
modifier: MODEL1310110012#
reversible: false
product: MODEL1310110012#
name: transport into the mitochondria (carnitine)
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110012#_2394fff9_f944_4f0f_bfe2_3db018b07ad1
is: P80404
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
name: ABAT
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:18

http://identifiers.org/biomodels.db/MODEL1310110012#_e72d9e2e_d5f6_413b_bf85_ca80af8c7f57
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: D9HTE9
boundary condition: true
name: SLC25A1
constant: false
is encoded by: hsa:6576

metaM stcrn c
name: stearoylcarnitine
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
is: SBO:0000247
is: HMDB00848
initial amount: NaN
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_3e10d051_ce12_415b_b9d9_ffcc6acb95bf
is: SBO:0000252
is encoded by: hsa:84720
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
name: PIGO

metaM 2oxoadp m
constant: false
is: CHEBI:57499
is: HMDB00225
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
boundary condition: false
initial concentration: 1.0
name: 2-oxoadipate(2-)

http://identifiers.org/biomodels.db/MODEL1310110012#_af04d83a_4bb9_480c_8592_1482eaf72a17
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
has part: E5KS60
name: SUCLG1:SUCLA2
is encoded by: hsa:8803
has only substance units: false

metaM 2ddecdicoa m
is: HMDB11123
name: 2,6-dodecadienoylcoa
constant: false
has only substance units: false
is: C05279
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4

metaR r0541
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.6.1.5

metaR INSTt2r
fast: false
is described by: ECO:0000269
is: SBO:0000185
name: inositol transport in via proton symport
type: Reaction
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
reversible: true
reactant: MODEL1310110012#

metaM Rtotal2 c
name: R total 2 position
is: SBO:0000247
boundary condition: false
is: CHEBI:57876
is: HMDB01564
has only substance units: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN

metaR 4NPHSULT
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.8.2.1
is: SBO:0000176
fast: false
reactant: MODEL1310110012#
modifier: MODEL1310110012#
name: 4-Nitrophenol Sulfotransferase
reversible: false
product: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)

metaM pacald c
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
is: SBO:0000247
initial amount: NaN
name: phenylacetaldehyde
constant: false
has only substance units: false
boundary condition: false
type: Species
is: HMDB06236
initial concentration: 1.0
is: CHEBI:16424

metaR r0246
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
product: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
reversible: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
kinetic law: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.3
type: Reaction

metaM dgsn m
initial concentration: 1.0
boundary condition: false
is: CHEBI:17172
constant: false
is: C00330
is: HMDB00085
name: Deoxyguanosine
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
has only substance units: false

metaR C161CRNt
is: SBO:0000185
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
fast: false
reversible: false
name: C161 transport into the mitochondria
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_067bc27d_fd62_4ae6_b3c8_49b0e9759fc4
type: Species
is: P19113
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: HDC
is encoded by: hsa:3067
has only substance units: false
is: SBO:0000252

metaR FAOXC12DCTc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dodecanedioyl carnitine into cytosol
type: Reaction

metaM dgmp m
type: Species
boundary condition: false
has only substance units: false
is: C00362
is: SBO:0000247
is: CHEBI:57673
name: dGMP
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
initial amount: NaN
is: HMDB01044
constant: false

metaM hmgcoa m
is: CHEBI:15467
constant: false
initial concentration: 1.0
is: HMDB01375
has only substance units: false
name: Hydroxymethylglutaryl-CoA
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356

http://identifiers.org/biomodels.db/MODEL1310110012#_ecd9842b_2fad_4e6c_9a2c_f7da30d08dc7
name: ACOT2
initial concentration: NaN
is: P49753
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10965
has only substance units: false
type: Species
initial amount: NaN

metaR r0249
is: SBO:0000176
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110012#
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.7.12
modifier: MODEL1310110012#
type: Reaction
reversible: true
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
kinetic law: MODEL1310110012#

metaM CE2839 e
type: Species
name: maltodecaose
is: SBO:0000247
boundary condition: false
constant: false
is: C01936
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_9b586ce3_2f56_4eaa_bdb2_663850bc06d4
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is: Q92643
boundary condition: true
is encoded by: hsa:10026
name: PIGK
initial amount: NaN
initial concentration: NaN

metaR FAOXC2031836m
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:3 -> c18:3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110012#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110012#
reactant: MODEL1310110012#
name: Beta oxidation of fatty acid
reversible: false
is: SBO:0000176
fast: false

metaR r0813
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
kinetic law: MODEL1310110012#
fast: false
is: SBO:0000185
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.9
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110012#
modifier: MODEL1310110012#

metaR GCC2bim
reversible: false
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
product: MODEL1310110012#
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.10
modifier: MODEL1310110012#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.4.2
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.4

metaM hspg e
initial amount: NaN
boundary condition: false
name: heparan sulfate proteoglycan
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB02259
constant: false
initial concentration: 1.0
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
is: CHEBI:32366

metaR RE2426C
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110012#
is described by: ECO:0000000
name: RE2426
product: MODEL1310110012#
reactant: MODEL1310110012#

metaM hs deg24 l
is: CHEBI:16126
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C31H50NO26 CHARGE: -1
is: SBO:0000247
name: GlcNAc-GlcA-(Gal)2-Xyl
initial concentration: 1.0
constant: false
type: Species

metaR ATPtm
product: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reversible: false
kinetic law: MODEL1310110012#
name: ADP/ATP transporter, mitochondrial
type: Reaction
is described by: ECO:0000269
is: SBO:0000185

metaM 3sala m
is: C00606
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:61085
name: 3-sulfino-L-alanine (1-)
initial amount: NaN
constant: false
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_974d0d67_0aaa_4ad5_a064_67e45e9e95ad
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:767
is: P35219
name: CA8
constant: false
has only substance units: false
type: Species
boundary condition: true

metaM 3hmbcoa m
has only substance units: false
constant: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
is: CHEBI:57312
type: Species
is: SBO:0000247
boundary condition: false
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
is: HMDB01356
initial amount: NaN
initial concentration: 1.0

metaR RE3626M
type: Reaction
is: SBO:0000176
reactant: MODEL1310110012#
is described by: ECO:0000000
modifier: MODEL1310110012#
product: MODEL1310110012#
name: RE3626
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
kinetic law: MODEL1310110012#

metaR PAIL4P HStn
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110012#
reversible: true
product: MODEL1310110012#
reactant: MODEL1310110012#
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false

metaR r1912
reactant: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
fast: false
modifier: MODEL1310110012#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is: SBO:0000185

metaM 4ppan c
initial amount: NaN
has only substance units: false
is: HMDB01016
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
constant: false
is: CHEBI:10986
boundary condition: false
is: C03492
name: D-4'-Phosphopantothenate
is: SBO:0000247
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_3cd00520_29cc_41fc_92dd_15ca41b4aa72
name: SLC16A8
boundary condition: true
is: O95907
type: Species
is: SBO:0000252
is encoded by: hsa:23539
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN

metaM itacon m
is: HMDB02092
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
is: CHEBI:17240
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
name: itaconate(2-)

metaR r0812
is version of: http://identifiers.org/ec-code/2.3.1.41
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
kinetic law: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110012#
fast: false
is: SBO:0000185
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
reactant: MODEL1310110012#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1

http://identifiers.org/biomodels.db/MODEL1310110012#_5f36efba_b0d2_4616_a09c_784cc52702f7
is: SBO:0000252
has only substance units: false
type: Species
constant: false
is: B3KQV3
boundary condition: true
is encoded by: hsa:79837
initial amount: NaN
name: PIP4K2C
initial concentration: NaN

metaM 3ddecdicoa m
type: Species
is: C05280
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
has only substance units: false
initial amount: NaN
name: 3,6-dodecadienoylcoa
is: HMDB03952

http://identifiers.org/biomodels.db/MODEL1310110012#_16f11ec0_3768_407f_95cb_46121bbc752c
initial concentration: NaN
is: SBO:0000252
name: PDE4B
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:5142
type: Species
is: Q5TEK5

metaR ASNtN1
reversible: true
product: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269
modifier: MODEL1310110012#
is: SBO:0000185
reactant: MODEL1310110012#
fast: false
name: Asparagine transport (Na, H coupled)
kinetic law: MODEL1310110012#

metaR r0698
is version of: http://identifiers.org/ec-code/3.1.2.27
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
fast: false
reversible: true
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
is: SBO:0000176
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000000
kinetic law: MODEL1310110012#
type: Reaction

metaR NDPK3m
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
is: SBO:0000176
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
modifier: MODEL1310110012#
is described by: ECO:0000254
fast: false
reversible: true
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#

metaR EX 11 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 11-cis-retinol exchange
type: Reaction

metaR FUT15g
is: SBO:0000176
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
is described by: ECO:0000269
type: Reaction
product: MODEL1310110012#
reversible: false
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.4.1.69
reactant: MODEL1310110012#
name: Galactoside 2-alpha-L-fucosyltransferase 1
fast: false

metaM pydx c
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB01545
initial concentration: 1.0
name: Pyridoxal
is: CHEBI:17310
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
initial amount: NaN
has only substance units: false
type: Species
is: C00250

metaM adrncoa x
is: http://identifiers.org/pubchem.compound/47205480
is: C16170
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
type: Species
name: adrenyl coenzyme A

metaM hs deg20 l
is: SBO:0000247
name: heparan sulfate, degradation product 20
initial concentration: 1.0
is: CHEBI:16126
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_abdfbf6d_8bb1_46dd_8f65_7862b856e0b9
is: SBO:0000252
type: Species
constant: false
name: LDHD
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:197257

http://identifiers.org/biomodels.db/MODEL1310110012#_3e15510a_e090_4c56_9912_84fcd67b8387
constant: false
boundary condition: true
name: ACP2
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:53
initial concentration: NaN
type: Species
is: E9PCI1

http://identifiers.org/biomodels.db/MODEL1310110012#_efe20d87_a3e4_483c_ba48_550a17304c3e
boundary condition: true
initial amount: NaN
has only substance units: false
has part: Q86U05
is encoded by: hsa:23428
name: SLC7A8:SLC3A2
type: Species
is: SBO:0000297
constant: false
initial concentration: NaN

metaM ile L e
type: Species
name: L-isoleucine
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial amount: NaN
is: CHEBI:17191
initial concentration: 1.0
is: HMDB00172
has only substance units: false
boundary condition: false
constant: false

metaR ALOX52
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.13.11.34
name: Arachidonate 5-lipoxygenase
is: SBO:0000176
product: MODEL1310110012#
modifier: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
reversible: false
fast: false
is described by: ECO:0000269

metaR GCHOLAte
reactant: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is described by: ECO:0000000
kinetic law: MODEL1310110012#
is: SBO:0000185
product: MODEL1310110012#
type: Reaction
fast: false
name: bile acid intracellular transport

metaR DPHMBDCm
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212,PMID:7380842 NOTES:enzyme has not been identified yet IT
type: Reaction
kinetic law: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000000
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate decarboxylation
reactant: MODEL1310110012#
fast: false
product: MODEL1310110012#

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

http://identifiers.org/biomodels.db/MODEL1310110012#_03759421_342f_4c8c_b31d_d6165679d08a
constant: false
boundary condition: true
initial concentration: NaN
name: ENTPD3
is: O75355
has only substance units: false
is encoded by: hsa:956
type: Species
is: SBO:0000252
initial amount: NaN

metaR 2HBt2
kinetic law: MODEL1310110012#
is described by: ECO:0000269
modifier: MODEL1310110012#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
fast: false
reactant: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
name: 2-hydroxybutyrate cotransport with proton
reversible: true

metaR ASNALANaEx
reactant: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
is: SBO:0000185
name: L-alanine/L-asparagine Na-dependent exchange (Asn-L in)
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
kinetic law: MODEL1310110012#
fast: false
product: MODEL1310110012#

metaR SPMTDe
is described by: ECO:0000134
product: MODEL1310110012#
type: Reaction
reversible: true
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110012#
is: SBO:0000185
name: SPMTDe

metaR G14T17g
fast: false
kinetic law: MODEL1310110012#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
product: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90

metaM glyc e
is: C00116
is: HMDB00131
has only substance units: false
is: CHEBI:17754
name: Glycerol
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR NDPK3n
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
is: SBO:0000176
product: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
kinetic law: MODEL1310110012#
fast: false
is described by: ECO:0000304

metaM hpdcacrn c
initial concentration: 1.0
name: heptadecanoyl carnitine
constant: false
is: HMDB06210
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
type: Species
is: SBO:0000247

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaR ESTSULT
type: Reaction
reactant: MODEL1310110012#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6783.1) or (6817.4) or (6817.1) or (6817.3) or (6817.2) or (6817.5) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.4 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:8185618 NOTES:NJ
fast: false
name: Estrogen sulfotransferase
kinetic law: MODEL1310110012#
reversible: false
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.8.2.1
is version of: http://identifiers.org/ec-code/2.8.2.4
is: SBO:0000176
product: MODEL1310110012#

metaR FAS80COA L
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110012#
product: MODEL1310110012#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110012#
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
kinetic law: MODEL1310110012#

metaR RE3272N
name: RE3272
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
reversible: true
product: MODEL1310110012#

metaM ile L c
type: Species
constant: false
name: L-isoleucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00172
initial amount: NaN
is: CHEBI:17191

metaR CHSTEROLt1
modifier: MODEL1310110012#
name: cholesterol intracellular transport
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
reversible: true
product: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
fast: false
is: SBO:0000185
is described by: ECO:0000304
reactant: MODEL1310110012#

metaM hs deg5 l
is: SBO:0000247
is: HMDB00158
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
name: heparan sulfate, degradation product 5
is: CHEBI:17895
type: Species
has only substance units: false

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_8ee24d40_0ff5_4d7d_a39f_b8dbc843f812
is encoded by: hsa:6487
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: ST3GAL3
is: Q5T4Y1

metaR r1090
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
fast: false
is: SBO:0000185
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_ee6255f7_8700_4a35_a5e7_360717ede20d
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4126
has only substance units: false
constant: false
name: MANBA
is: O00462
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_b0bcbd44_9e1d_4b19_8b9b_e06f2550d4f4
constant: false
name: RBAK
is encoded by: hsa:57786
has only substance units: false
is: Q9NYW8
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN

metaR RE2973C
reactant: MODEL1310110012#
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.1.154
fast: false
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.153
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.137
name: RE2973
reversible: true
type: Reaction

metaR AGMTm
is: SBO:0000176
reactant: MODEL1310110012#
fast: false
name: agmatinase (m)
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.5.3.11
product: MODEL1310110012#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (79814.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 3.5.3.11 Confidence Level: 4 AUTHORS: PMID:11804860,PMID:11914032,PMID:15028567,PMID:15465778 NOTES:SAB m
is described by: ECO:0000269

metaM dec47dicoa m
boundary condition: false
has only substance units: false
name: 4,7-decadienoylcoa
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_faf3f24a_cea0_40fb_8069_3c9b2b91805f
type: Species
is: P33121
has only substance units: false
initial amount: NaN
name: ACSL1
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2180

metaR CHSTEROLt2
product: MODEL1310110012#
name: cholesterol intracellular transport
is: SBO:0000185
fast: false
kinetic law: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110012#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_5c2b0fa1_1d4d_41d6_b82f_34eca14af050
has only substance units: false
is encoded by: hsa:8310
initial amount: NaN
name: ACOX3
initial concentration: NaN
is: O15254
type: Species
boundary condition: true
is: SBO:0000252
constant: false

metaM hmgcoa x
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
name: Hydroxymethylglutaryl-CoA
is: HMDB01375
is: CHEBI:15467
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: SBO:0000247

metaR PVD3
is: SBO:0000176
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
reactant: MODEL1310110012#
name: Previtamin D3 formation
type: Reaction
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reversible: true

metaR DHCR243r
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
is described by: ECO:0000134
product: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.72
name: 24-dehydrocholesterol reductase [Precursor]
fast: false
reversible: false
modifier: MODEL1310110012#

metaR r0549
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
reactant: MODEL1310110012#
fast: false
is: SBO:0000176
product: MODEL1310110012#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.6.5.3
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
is version of: http://identifiers.org/ec-code/6.1.1.17
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.6.99.3
kinetic law: MODEL1310110012#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_b3157477_38bf_454a_92cb_32b5baa77c17
initial amount: NaN
boundary condition: true
name: ADCY6
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:112
is: SBO:0000252
type: Species

metaR CHSTEROLt3
reversible: true
product: MODEL1310110012#
name: cholesterol intracellular transport
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_25ac66d9_c37e_4937_bd8c_86d414c2f7c8
is encoded by: hsa:441024
name: MTHFD2L
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q9H903
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

metaM malt e
is: C00208
is: HMDB00163
initial amount: NaN
is: SBO:0000247
is: CHEBI:17306
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
name: Maltose

http://identifiers.org/biomodels.db/MODEL1310110012#_bad4c2e0_005d_488e_8dac_b164e8d6bd89
is encoded by: hsa:65263
constant: false
is: SBO:0000252
type: Species
is: Q53H96
name: PYCRL
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM c4dc x
constant: false
is: SBO:0000247
name: succinyl carnitine
type: Species
initial concentration: 1.0
has only substance units: false
is: C02862
initial amount: NaN
is: HMDB02013
boundary condition: false
notes: FORMULA: C11H18NO6 CHARGE: -1
is: http://identifiers.org/pubchem.compound/213144

metaR DOLPH Uer
product: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
reversible: false
is: SBO:0000176
fast: false
name: Dolichol-phosphate phosphohydrolase, human (uterus)
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000000

metaM bamppald c
is: HMDB01106
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7975
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
is: C05665
type: Species
has only substance units: false
initial amount: NaN
name: beta-Aminopropion aldehyde

http://identifiers.org/biomodels.db/MODEL1310110012#_1dcff9f9_6357_467d_bbe3_c6a3b5c5fe3f
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10587
type: Species
is: SBO:0000252
name: TXNRD2

metaR LEUKTRE4t
kinetic law: MODEL1310110012#
name: leukotriene E4 transport
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
is: SBO:0000185

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaM hspg l
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
boundary condition: false
has only substance units: false
name: heparan sulfate proteoglycan
is: CHEBI:17899
type: Species
constant: false
is: HMDB01993
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM 34dhmald m
type: Species
is: SBO:0000247
name: 3,4-Dihydroxymandelaldehyde
is: HMDB06242
is: http://identifiers.org/pubchem.compound/7903
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
constant: false
initial concentration: 1.0
is: C05577
boundary condition: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_89a6f57e_18e4_4e88_839f_c966d095db45
type: Species
is: P08319
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
name: ADH4
is: SBO:0000252
is encoded by: hsa:127

metaR H2ETer
reactant: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
reversible: false
kinetic law: MODEL1310110012#
type: Reaction
name: H2 phosphoethanolaminyl transferase, endoplasmic reticulum
product: MODEL1310110012#
is described by: ECO:0000304
modifier: MODEL1310110012#
fast: false

metaM 2ddecdicoa x
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: C05279
is: SBO:0000247
name: 2,6-dodecadienoylcoa
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
constant: false
is: HMDB11123
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_a4bf354b_fbfb_4802_82a8_03223db5daa5
is: SBO:0000252
type: Species
initial concentration: NaN
name: ENTPD2
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:954
is: Q5SPY7
constant: false

metaM pydx e
is: C00250
name: Pyridoxal
is: CHEBI:17310
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB01545
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_8c8ba5a9_d752_47bf_a330_54f885b0f6b5
type: Species
is: P32189
is encoded by: hsa:2710
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
name: GK
boundary condition: true

metaM ppcoa m
is: C00100
is: CHEBI:57392
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
name: Propanoyl-CoA
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: HMDB01275
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_bc5f20bd_f03a_488a_b634_52d4a6e1862a
is: Q9H999
initial amount: NaN
initial concentration: NaN
name: PANK3
is encoded by: hsa:79646
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
type: Species

metaM 2hexdtricoa m
is: HMDB02288
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
boundary condition: false
name: 2,7,10-hexadecatrienoylcoa
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR DOLPGT2 Uer
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.265
modifier: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
reversible: false
is: SBO:0000176
product: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
type: Reaction

metaM 3hbcoa m
name: (S)-3-hydroxybutanoyl-CoA(4-)
constant: false
is: SBO:0000247
is: CHEBI:57316
is: HMDB01166
has only substance units: false
boundary condition: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
initial amount: NaN
initial concentration: 1.0
type: Species

metaR N3Tg
modifier: MODEL1310110012#
reversible: false
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
product: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.122
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
is: SBO:0000176

metaR DHCR71r
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
is version of: http://identifiers.org/ec-code/1.3.1.21
name: 7-dehydrocholesterol reductase
reversible: false
is described by: ECO:0000134
reactant: MODEL1310110012#
is: SBO:0000176
fast: false
type: Reaction

metaR r2002
kinetic law: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
fast: false
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
is: SBO:0000185
reversible: false

metaM c3dc c
notes: FORMULA: C10H16NO6 CHARGE: -1
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
name: malonyl carnitine
initial concentration: 1.0
constant: false
is: HMDB02095

metaR ME1m
is version of: http://identifiers.org/ec-code/1.1.1.38
modifier: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
name: malic enzyme (NAD), mitochondrial
fast: false
type: Reaction

metaR EX man LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Mannose
type: Reaction

metaR Rtotaltl
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: fatty acid intracellular transport
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - carnitine transporters not found, unknown mechanism intracellularly, however there must be a mechanism for FA transport NJ
fast: false
reversible: true
product: MODEL1310110012#

metaR r1611
reactant: MODEL1310110012#
is described by: ECO:0000000
product: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110012#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_5aff753e_7cc0_4662_9892_4619ba54e29c
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: ATP5J2
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9551
is: F8W7V3

metaM cholp g
boundary condition: false
has only substance units: false
name: choline phosphate(1-)
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
initial concentration: 1.0
is: CHEBI:295975
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
is: C00588

metaM pail45p hs c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
has only substance units: false
is: CHEBI:28910
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
name: phosphatidylinositol 4,5-bisphosphate

metaM s2l2n2m2masn l
initial amount: NaN
is: CHEBI:18287
constant: false
has only substance units: false
is: HMDB00174
type: Species
is: SBO:0000247
name: de-Fuc form of PA6
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C84H135N6O61X CHARGE: -2

metaR r0660
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110012#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
modifier: MODEL1310110012#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000176

metaM lanost r
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
name: lanosterol
is: HMDB01251
has only substance units: false
is: SBO:0000247
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
initial amount: NaN
is: CHEBI:16521

http://identifiers.org/biomodels.db/MODEL1310110012#_adbbf676_0f35_4a7e_b6f0_2f05a9d84663
name: DDOST
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:1650
type: Species
is: P39656
initial amount: NaN
initial concentration: NaN

metaM Ssq23epx r
name: (S)-2,3-epoxysqualene
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15441
constant: false
is: HMDB01188
boundary condition: false
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
type: Species

metaM CE2421 m
name: (3S)-3-hydroxylinoleoyl-CoA
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
constant: false
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
is: HMDB02329
boundary condition: false
is: CHEBI:30623
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_444f36b4_b032_439d_9aea_538bc3387121
constant: false
is encoded by: hsa:125206
initial concentration: NaN
is: A0PJK1
name: SLC5A10
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false

metaM CE0713 m
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:30623
is: SBO:0000247
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
constant: false
is: HMDB02329
name: 3-oxolinoleoyl-CoA
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_80a7f9f3_9ffc_4d3d_9ff6_b6b31d67a860
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
name: GMPR2
initial amount: NaN
is encoded by: hsa:51292
type: Species
is: SBO:0000252

metaR FATP7t
modifier: MODEL1310110012#
name: fatty acid electroneutral transport
is version of: http://identifiers.org/ec-code/6.2.1.7
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
type: Reaction
product: MODEL1310110012#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000185
fast: false
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#

metaR r1610
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110012#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110012#
product: MODEL1310110012#

metaR THCHOLSTOICtm
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110012#
kinetic law: MODEL1310110012#
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110012#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ

metaM elaid e
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:30825
name: elaidate
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
is: HMDB00573
boundary condition: false
is: SBO:0000247
type: Species

metaR FAOXC123C102x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_0ab296b5_3285_440c_bd91_58a5d1753588
initial concentration: NaN
is encoded by: hsa:271
is: E9PNG0
has only substance units: false
constant: false
type: Species
name: AMPD2
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR HDDACBP
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

metaR r0661
kinetic law: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
is described by: ECO:0000000
reversible: false
product: MODEL1310110012#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110012#_ba7c6468_eb58_476d_bc7f_6bb223e48376
constant: false
is: SBO:0000252
name: ECH1
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1891
has only substance units: false
is: Q13011

metaR GGH 5THFe
kinetic law: MODEL1310110012#
fast: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
is: SBO:0000176
name: Gamma-glutamyl hydrolase (5THF), extracellular
reactant: MODEL1310110012#
product: MODEL1310110012#
reversible: false

metaR FAOXC204
kinetic law: MODEL1310110012#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110012#
is described by: ECO:0000269
type: Reaction
name: Beta oxidation of long chain fatty acid
fast: false
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reactant: MODEL1310110012#
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM 56dthm c
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
name: 5,6-dihydrothymine
is: CHEBI:27468
boundary condition: false
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
is: HMDB00079
type: Species

metaR UDPtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
is described by: ECO:0000000
product: MODEL1310110012#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: true
fast: false
name: udp intracellular transport

metaR r1613
reversible: true
is described by: ECO:0000000
product: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
reactant: MODEL1310110012#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_f998b3e4_4772_4783_8712_b5bf72dbeee7
is: SBO:0000252
name: BCMO1
is encoded by: hsa:53630
constant: false
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q9HAY6

metaR NACHEX19ly
reversible: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110012#
is: SBO:0000176
product: MODEL1310110012#
modifier: MODEL1310110012#
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110012#
is described by: ECO:0000000

metaR r2000
fast: false
type: Reaction
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110012#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110012#

metaM hdd2crn c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
type: Species
is: HMDB06317
constant: false
has only substance units: false
is: SBO:0000247
name: trans-Hexadec-2-enoyl carnitine
boundary condition: false

metaM lnlnca c
type: Species
is: HMDB01388
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:32387
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: SBO:0000247
name: alpha-linolenate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_1c9902c7_de83_40a4_b743_213cf3e43510
is encoded by: hsa:3251
is: SBO:0000252
name: HPRT1
is: P00492
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_7c12d0b2_c126_4a25_8620_655db27a0483
is: SBO:0000252
name: DPM3
boundary condition: true
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: Q86TM7
is encoded by: hsa:54344

metaR r0129
kinetic law: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
reactant: MODEL1310110012#
modifier: MODEL1310110012#
fast: false
is described by: ECO:0000000
product: MODEL1310110012#
is: SBO:0000176
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is version of: http://identifiers.org/ec-code/2.7.1.40
type: Reaction

metaR GLCAASE9ly
type: Reaction
reactant: MODEL1310110012#
product: MODEL1310110012#
fast: false
reversible: false
is described by: ECO:0000269
name: beta-glucuronidase, lysosomal
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.31
is: SBO:0000176

metaR NACHEX22ly
kinetic law: MODEL1310110012#
reversible: false
fast: false
modifier: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110012#
is: SBO:0000176
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.52

metaM 3hmp m
initial concentration: 1.0
name: 3-hydroxy-2-methylpropanoate
is: HMDB00023
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:11805
type: Species
initial amount: NaN

metaR GLUPRT
name: glutamine phosphoribosyldiphosphate amidotransferase
is version of: http://identifiers.org/ec-code/2.4.2.14
modifier: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
reactant: MODEL1310110012#

metaM CE2917 e
is: C01936
boundary condition: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C69H114N23O16S CHARGE: 3 INCHI: InChI=1/C69H111N23O16S/c1-39(2)32-47(86-58(98)44(17-9-26-78-68(73)74)83-63(103)52-20-12-29-91(52)65(105)45(18-10-27-79-69(75)76)84-56(96)42(71)22-23-54(72)94)59(99)89-50(37-93)61(101)87-48(34-41-35-77-38-81-41)60(100)82-43(16-7-8-25-70)57(97)80-36-55(95)90-28-11-19-51(90)62(102)85-46(24-31-109-3)66(106)92-30-13-21-53(92)64(104)88-49(67(107)108)33-40-14-5-4-6-15-40/h4-6,14-15,35,38-39,42-53,93H,7-13,16-34,36-37,70-71H2,1-3H3,(H2,72,94)(H,77,81)(H,80,97)(H,82,100)(H,83,103)(H,84,96)(H,85,102)(H,86,98)(H,87,101)(H,88,104)(H,89,99)(H,107,108)(H4,73,74,78)(H4,75,76,79)/p+3/t42-,43-,44-,45+,46-,47+,48+,49+,50-,51+,52+,53-/m1/s1 EHMN_ABBREVIATION: CE2917
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
name: apelin-13

http://identifiers.org/biomodels.db/MODEL1310110012#_3870c9cc_a74f_480c_beea_0686753bd234
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P31040
is encoded by: hsa:6389
constant: false
has only substance units: false
name: SDHA

metaM dhap x
name: Dihydroxyacetone phosphate
boundary condition: false
is: http://identifiers.org/pubchem.compound/3411
is: SBO:0000247
is: HMDB01473
constant: false
is: C00111
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57642
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_8cefbf68_221c_4247_84d6_0a67be05d3e0
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: INPP5J
is encoded by: hsa:27124
initial concentration: NaN
is: Q15735
boundary condition: true
is: SBO:0000252

metaR ORNt4m
is described by: ECO:0000269
product: MODEL1310110012#
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
fast: false
name: ornithine mitochondrial transport exchange with citruline
reversible: true

metaM elaid c
is: HMDB00573
constant: false
initial amount: NaN
boundary condition: false
type: Species
name: elaidate
is: CHEBI:30825
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830

metaR r1612
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110012#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
fast: false

metaM occoa m
is: CHEBI:57386
is: SBO:0000247
type: Species
is: HMDB01070
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
name: Octanoyl-CoA (n-C8:0CoA)
boundary condition: false
is: C01944
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944

metaM lnlccoa c
is: HMDB01064
initial concentration: 1.0
type: Species
is: SBO:0000247
name: linoleic coenzyme A
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/5462164

metaM xol7ah2 c
is: SBO:0000247
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: HMDB06893
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:28047
type: Species
name: 5beta-cholestane-3alpha,7alpha-diol
boundary condition: false
initial amount: NaN

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_4b1cf0c5_65d5_4dc6_bf40_50067da99d41
is encoded by: hsa:5335
type: Species
name: PLCG1
has only substance units: false
constant: false
initial concentration: NaN
is: Q9UFY1
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM 2hexdtetcoa m
is: HMDB02288
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
name: 2,7,10,13-hexadecatetraenoylcoa
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR PROGLYPRO1c
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of glycylproline in the small intestine for cellular uptake
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_1b0e274f_1daa_401c_a18f_84029710063a
constant: false
is encoded by: hsa:4710
initial amount: NaN
name: NDUFB4
is: SBO:0000252
is: O95168
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species

metaM h2o c
name: H2O
is: CHEBI:3303
notes: FORMULA: H2O CHARGE: 0
has only substance units: false
type: Species
initial amount: NaN
is: HMDB02111
is: C00001
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM acglcgalgluside hs g
is: CHEBI:17103
initial concentration: 1.0
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0
name: N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_338961fa_1cd0_461b_84fd_14e46f165fe4
initial concentration: NaN
type: Species
boundary condition: true
is: Q9BXS1
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:91734
name: IDI2

metaM h r
is: CHEBI:24636
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
is: C00080
boundary condition: false
initial amount: NaN
type: Species
name: proton
is: SBO:0000247
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
constant: false

metaM 11 cis retfa e
has only substance units: false
boundary condition: false
name: fatty acid 11-cis-retinol
is: HMDB00972
initial concentration: 1.0
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:57454
type: Species

metaR PPA
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000269
reactant: MODEL1310110012#
name: inorganic diphosphatase
kinetic law: MODEL1310110012#
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.1
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:

metaR CSNATer
is: SBO:0000176
reversible: true
is described by: ECO:0000254
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (1384.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:11257506,PMID:3759988 NOTES:mm
is version of: http://identifiers.org/ec-code/2.3.1.7
type: Reaction
modifier: MODEL1310110012#
name: carnitine O-acetyltransferase, endolasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110012#_7b15caff_0d78_4ee9_8344_8bc20b8130db
is: SBO:0000252
is: O75251
initial amount: NaN
constant: false
name: NDUFS7
initial concentration: NaN
boundary condition: true
is encoded by: hsa:374291
type: Species
has only substance units: false

metaM lnlnca e
is: HMDB01388
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:32387
has only substance units: false
constant: false
name: alpha-linolenate

metaR NACHEX11ly
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110012#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
is: SBO:0000176

metaR EX c16dc
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecanedioic acid mono-L-carnitine ester
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_895256dd_4f98_4a84_9208_ad0fee62e862
constant: false
initial amount: NaN
name: NDUFA3
is: O95167
is: SBO:0000252
type: Species
is encoded by: hsa:4696
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_02634a11_a151_434c_952a_8cbf8bbd1c64
constant: false
is encoded by: hsa:6487
boundary condition: true
name: ST3GAL3
type: Species
is: SBO:0000252
has only substance units: false
is: B4DX62
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_737ac361_c980_402f_b773_f22cbb5a674b
is: Q0VAA5
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:257068
is: SBO:0000252
constant: false
name: PLCXD2
boundary condition: true
initial concentration: NaN

metaR RE1527M
fast: false
reactant: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110012#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110012#
name: RE1527
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:

metaM h2o e
boundary condition: false
is: CHEBI:15377
name: H2O
type: Species
constant: false
is: C00001
initial amount: NaN
has only substance units: false
is: HMDB02111
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

http://identifiers.org/biomodels.db/MODEL1310110012#_26ca780c_387c_42a8_8d50_8714f6ae49be
is: SBO:0000252
name: GSTZ1
is encoded by: hsa:2954
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: A6NED0

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaM coucoa m
is: CHEBI:57355
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: C00223
initial amount: NaN
name: 4-coumaroyl-CoA(4-)
notes: FORMULA: C30H38N7O18P3S1 CHARGE: -4 INCHI: InChI=1S/C30H42N7O18P3S/c1-30(2,25(42)28(43)33-10-9-20(39)32-11-12-59-21(40)8-5-17-3-6-18(38)7-4-17)14-52-58(49,50)55-57(47,48)51-13-19-24(54-56(44,45)46)23(41)29(53-19)37-16-36-22-26(31)34-15-35-27(22)37/h3-8,15-16,19,23-25,29,38,41-42H,9-14H2,1-2H3,(H,32,39)(H,33,43)(H,47,48)(H,49,50)(H2,31,34,35)(H2,44,45,46)/p-4/t19-,23-,24-,25+,29-/m1/s1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_f51ca8b1_e119_406d_8ccc_f478abf93fcc
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is: B4DUY1
has only substance units: false
is encoded by: hsa:10948
name: STARD3
constant: false
is: SBO:0000252

metaM andrstndn r
is: SBO:0000247
notes: FORMULA: C19H26O2 CHARGE: 0 INCHI: InChI=1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00280
is: CHEBI:16422
name: androst-4-ene-3,17-dione
is: HMDB00053
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR PI45P5P
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
kinetic law: MODEL1310110012#
reversible: false
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.36
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
modifier: MODEL1310110012#
reactant: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
is: SBO:0000176

metaR EX 3thexddcoacrn
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy trans7,10-hexadecadienoyl carnitine
type: Reaction

metaR ATPH2e
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.5
fast: false
name: ATP diphosphohydrolase
is version of: http://identifiers.org/ec-code/3.6.1.6
modifier: MODEL1310110012#
reversible: false
notes: GENE_ASSOCIATION: (954.2) or (954.1) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
kinetic law: MODEL1310110012#
is: SBO:0000176
type: Reaction
product: MODEL1310110012#
reactant: MODEL1310110012#

metaR HIBDm
reversible: true
product: MODEL1310110012#
type: Reaction
fast: false
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
is described by: ECO:0000269
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.1.1.31
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
is: SBO:0000176
reactant: MODEL1310110012#

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaM CE4794 m
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
name: cis-6-dodecenoyl-CoA
constant: false
type: Species
is: CHEBI:57923
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_c3e938c5_9c3c_4d5e_94cf_5e9085ce6ce7
boundary condition: true
is: SBO:0000252
is: Q9UNP4
has only substance units: false
initial amount: NaN
constant: false
name: ST3GAL5
is encoded by: hsa:8869
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_7ba65373_af0d_445d_9aae_9171db605c96
name: ASRGL1
boundary condition: true
type: Species
has only substance units: false
is: Q7L266
constant: false
is encoded by: hsa:80150
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR ADK1m
fast: false
product: MODEL1310110012#
reversible: true
name: adenylate kinase, mitochondrial
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000269
type: Reaction

metaR C81CRNe
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octenoyl carnitine into the extra cellular space
type: Reaction

metaM s2l2n2m2masn e
is: HMDB00244
is: C00255
name: de-Fuc form of PA6
has only substance units: false
is: CHEBI:3554
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C84H135N6O61X CHARGE: -2
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_c67cfd3c_3aeb_435b_be8a_22e95269d73b
boundary condition: true
has only substance units: false
is: SBO:0000252
name: SUOX
constant: false
initial amount: NaN
is encoded by: hsa:6821
initial concentration: NaN
is: P51687
type: Species

metaR H6ET3er
is: SBO:0000176
type: Reaction
reactant: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000000
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
kinetic law: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.7.8.1
modifier: MODEL1310110012#

metaR LPCOXp
modifier: MODEL1310110012#
product: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
type: Reaction
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.5.3.1
name: L-pipecolate oxidase, peroxisomal
reactant: MODEL1310110012#
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110012#_b3872b55_050b_4007_8d60_1bb8b6480c7e
name: GPAA1
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8733
has only substance units: false
boundary condition: true
is: O43292
initial concentration: NaN
constant: false

metaM h2o g
is: CHEBI:15377
boundary condition: false
constant: false
type: Species
name: water
initial amount: NaN
is: HMDB02111
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

metaR ARACHDtr
name: intracellular transport
reactant: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
kinetic law: MODEL1310110012#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110012#
type: Reaction

metaM fuc12gal14acglcgalgluside hs g
notes: FORMULA: C50H89N2O26FULLRCO CHARGE: 0
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:57847
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00304
constant: false
name: Type IIH glycolipid

http://identifiers.org/biomodels.db/MODEL1310110012#_c19cda07_9a89_4cc9_aad4_4c867c379592
name: PGAP1
constant: false
boundary condition: true
is: Q75T13
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:80055
is: SBO:0000252

metaM dudp c
is: CHEBI:60471
initial amount: NaN
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
type: Species
boundary condition: false
is: C01346
is: SBO:0000247
is: HMDB01000
initial concentration: 1.0
name: dUDP
constant: false
has only substance units: false

metaM hs deg3 l
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
is: SBO:0000247
is: CHEBI:16126
initial concentration: 1.0
boundary condition: false
type: Species
name: heparan sulfate, degradation product 3

http://identifiers.org/biomodels.db/MODEL1310110012#_7c564a95_1e4b_4bad_8be9_ca95748155b4
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
name: NDUFC1
has only substance units: false
type: Species
is encoded by: hsa:4717
is: SBO:0000252
is: O43677

metaR EX pydx LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Pyridoxal
type: Reaction

metaM ins e
name: Inosine
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:17596
initial amount: NaN
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: HMDB00195
type: Species
is: SBO:0000247
is: C00294

metaM 2hexdtetcoa x
initial amount: NaN
has only substance units: false
boundary condition: false
name: 2,7,10,13-hexadecatetraenoylcoa
is: HMDB02288
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_4be2101c_8814_40d2_ad54_23c015f6ab54
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P24311
name: COX7B
constant: false
has only substance units: false
is encoded by: hsa:1349

metaM chlstol r
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB06842
is: CHEBI:16290
type: Species
name: 5alpha-cholesta-7,24-dien-3beta-ol
constant: false

metaM h n
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
constant: false
is: CHEBI:24636
is: SBO:0000247
type: Species
name: proton

http://identifiers.org/biomodels.db/MODEL1310110012#_a938f157_58c0_4d28_a47e_76b1a172494f
initial amount: NaN
boundary condition: true
constant: false
name: GMPS
is encoded by: hsa:8833
type: Species
has only substance units: false
is: SBO:0000252
is: P49915
initial concentration: NaN

metaM hdd2crn m
initial concentration: 1.0
is: SBO:0000247
is: HMDB06317
constant: false
type: Species
boundary condition: false
name: trans-Hexadec-2-enoyl carnitine
initial amount: NaN
has only substance units: false
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+

metaR AG13T1g
modifier: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
kinetic law: MODEL1310110012#
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110012#

metaR r1619
is described by: ECO:0000000
kinetic law: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110012#
product: MODEL1310110012#
fast: false
reactant: MODEL1310110012#

metaR HEDCECRNe
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecenoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_e54cb14e_1e06_4f77_a2e0_e80dd13a3b58
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: O75438
initial amount: NaN
type: Species
name: NDUFB1
is encoded by: hsa:4707
is: SBO:0000252

metaM HC01842 c
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
has only substance units: false
initial concentration: 1.0
name: Phosphodimethylethanolamine
constant: false
type: Species
is: SBO:0000247
is: CHEBI:31997

metaM HC00460 c
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
is: CHEBI:58044
name: 2,5-dihydroxybenzoate
constant: false
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR EX strch1 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: starch, structure 1 (1,6-{7[1,4-Glc], 4[1,4-Glc]}) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_d47aed7d_14b3_4ccb_969a_517f6851a9f4
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:4696
initial concentration: NaN
is: O95167
initial amount: NaN
name: NDUFA3

http://identifiers.org/biomodels.db/MODEL1310110012#_287adbaa_3635_4ccb_8864_b14ace88be37
is encoded by: hsa:3098
constant: false
name: HK1
type: Species
initial concentration: NaN
boundary condition: true
is: B3KXY9
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM tetpent3coa c
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: C16167
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
name: tetracosapentaenoyl coenzyme A, n-3
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110012#_e18bfb76_bc53_4450_9705_87821340cf18
has only substance units: false
initial amount: NaN
boundary condition: true
name: SDR16C5
is: B3KT84
is: SBO:0000252
is encoded by: hsa:195814
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_148b7416_3e3a_427b_b179_b17057bd198d
boundary condition: true
constant: false
is encoded by: hsa:AA629629
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: _AA629629_1_m
initial concentration: NaN

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaR DHORTS
kinetic law: MODEL1310110012#
name: dihydroorotase
reversible: true
type: Reaction
is described by: ECO:0000269
product: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
reactant: MODEL1310110012#
fast: false
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.1.3.2

metaM h m
name: proton
is: CHEBI:24636
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/3380
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
boundary condition: false
is: C00080
constant: false
initial amount: NaN

metaR ARGDCm
is version of: http://identifiers.org/ec-code/4.1.1.19
product: MODEL1310110012#
kinetic law: MODEL1310110012#
name: arginine decarboxylase (m)
notes: GENE_ASSOCIATION: (113451.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.19 Confidence Level: 4 AUTHORS: PMID:14752610 NOTES:SAB m
reversible: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110012#_798ca31a_2d06_463b_892e_1c4e1a7f2cef
is: Q99808
boundary condition: true
is encoded by: hsa:2030
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: SLC29A1
has only substance units: false
is: SBO:0000252

metaR r1618
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110012#
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110012#
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110012#_9eecc2e4_602d_4680_9452_1b539f9af3f5
type: Species
initial concentration: NaN
is encoded by: hsa:4598
boundary condition: true
is: B2RDU6
initial amount: NaN
name: MVK
is: SBO:0000252
constant: false
has only substance units: false

metaM c6dc c
type: Species
initial amount: NaN
is: SBO:0000247
name: adipoyl carnitine
initial concentration: 1.0
is: HMDB00705
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C13H22NO6 CHARGE: -1

metaM pail45p hs m
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:28910
has only substance units: false
is: SBO:0000247
type: Species
name: phosphatidylinositol 4,5-bisphosphate
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial amount: NaN

metaR SPC HSt
reactant: MODEL1310110012#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
fast: false
name: sphingosylphosphorylcholine transport (diffusion)
reversible: true
is described by: ECO:0000000
product: MODEL1310110012#
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_b0ce9d9c_35a9_44ce_a8ef_1113931aa2fd
is encoded by: hsa:U37519
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
name: _U37519_1_e
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM h l
notes: FORMULA: H CHARGE: 1 INCHI: "
initial amount: NaN
name: proton
constant: false
is: CHEBI:24636
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: C00080
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380

http://identifiers.org/biomodels.db/MODEL1310110012#_cddc93f0_bee5_47a4_807d_26bf013fcc11
initial amount: NaN
initial concentration: NaN
name: _R39999_1_c
is encoded by: hsa:R39999
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
type: Species

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaR STRDNCCPT1
product: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine O-palmitoyltransferase

metaM pail45p hs n
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:28910
name: phosphatidylinositol 4,5-bisphosphate

metaM Rtotal2coa c
name: R total 2 coenzyme A
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00294
type: Species
has only substance units: false
is: C00086
initial concentration: 1.0
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
is: CHEBI:16199

metaM hexdectecoa x
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB02288
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: 2,4,7,10-hexadecatetraenoylcoa

metaM CE5161 r
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161
initial concentration: 1.0
initial amount: NaN
type: Species
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA
is: CHEBI:57923

http://identifiers.org/biomodels.db/MODEL1310110012#_60d59847_8e2b_4cb9_a6a3_ceed456e6509
name: GALT
boundary condition: true
type: Species
is: B2RAT6
is encoded by: hsa:2592
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM ksi pre13 g
is: CHEBI:58053
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
name: keratan sulfate I biosynthesis, precursor 13
boundary condition: false
is: HMDB00175
is: C00130

metaR TCHOLAte
type: Reaction
reversible: true
name: bile acid intracellular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#

metaM doldp U r
name: Dolichol diphosphate, human uterine homolog
is: CHEBI:15750
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C1025H1670O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
constant: false
initial concentration: 1.0
type: Species
has only substance units: false

metaM Tyr ggn e
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB06409
notes: FORMULA: XOH CHARGE: 0
boundary condition: false
name: Tyr-194 of apo-glycogenin protein (primer for glycogen synthesis)
initial amount: NaN

metaR STRDNCCPT2
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
modifier: MODEL1310110012#
name: carnitine transferase
type: Reaction
product: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
reversible: false
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_b84ad42e_7d92_4799_88ea_a3b60642a78e
type: Species
boundary condition: true
initial concentration: NaN
name: _642502_1_c
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:642502

http://identifiers.org/biomodels.db/MODEL1310110012#_c57e13e1_b7c7_4525_aab1_81f3447ae990
name: ENTPD8
initial amount: NaN
is: SBO:0000252
is: Q5MY95
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:377841

metaM 13 cis retn r
constant: false
is: http://identifiers.org/pubchem.compound/7847414
initial amount: NaN
is: D00348
name: 13-cis-retinoate
initial concentration: 1.0
type: Species
is: HMDB06219
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
boundary condition: false

metaM 5oxpro c
name: 5-oxoprolinate
type: Species
is: HMDB00267
constant: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
is: CHEBI:57606
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR ADA
reactant: MODEL1310110012#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110012#
is: SBO:0000176
name: Adenosine deaminase
is version of: http://identifiers.org/ec-code/3.5.4.4
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
type: Reaction
product: MODEL1310110012#
fast: false

metaR FAS180COA
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000269
reactant: MODEL1310110012#
name: fatty-acyl-CoA synthase (n-C18:0CoA)
type: Reaction
fast: false
reversible: false
product: MODEL1310110012#
is: SBO:0000176
kinetic law: MODEL1310110012#

metaM mhista c
name: N(tele)-methylhistaminium
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H12N3 CHARGE: 1 INCHI: InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3/p+1 EHMN_ABBREVIATION: C05127
type: Species
is: HMDB00898
is: CHEBI:58600
is: SBO:0000247

metaR THRGLNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110012#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000269
name: L-threonine/L-glutamine Na-dependent exchange (Thr-L in)
type: Reaction
reactant: MODEL1310110012#
fast: false

metaR r1615
is described by: ECO:0000000
reactant: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110012#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110012#
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_84086dbf_eb47_464d_8b25_09d1b93fac61
is: SBO:0000252
is encoded by: hsa:22934
constant: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
name: RPIA
is: P49247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_773917c9_fd01_4402_9bb9_c1dcaca1b6fd
is encoded by: hsa:2936
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is: P00390
name: GSR
has only substance units: false
initial concentration: NaN
type: Species

metaR r0552
is: SBO:0000176
fast: false
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
is version of: http://identifiers.org/ec-code/1.3.5.1
product: MODEL1310110012#
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
reactant: MODEL1310110012#
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_cf6f99eb_6304_4239_97bc_97b3246c6626
is: Q9NR34
initial concentration: NaN
name: MAN1C1
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:57134

metaR SIAASEly
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
modifier: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110012#
name: sialidase, lysosomal
fast: false

metaR BTND1
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.12
kinetic law: MODEL1310110012#
name: biotinidase (biotin)
is described by: ECO:0000269
product: MODEL1310110012#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:IT
modifier: MODEL1310110012#
reactant: MODEL1310110012#
reversible: false

metaM hpdcacoa c
is: HMDB06497
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: heptadecanoyl coa
boundary condition: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110012#_0943e2f0_cb88_4ca3_a346_f30a494e3a75
is encoded by: hsa:PRO1933
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: _PRO1933_1_m
type: Species
is: SBO:0000252
boundary condition: true

metaR r1614
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
modifier: MODEL1310110012#
reactant: MODEL1310110012#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r1939
type: Reaction
modifier: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110012#
reversible: false
is: SBO:0000185

metaM octa c
is: CHEBI:25646
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H15O2 CHARGE: -1
initial concentration: 1.0
name: octanoate (n-C8:0)
has only substance units: false
is: C06423
constant: false
is: HMDB00482
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_2ab0db53_94cc_41d7_af50_5a53c4fe1b21
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1373
initial amount: NaN
is: Q59HF8
type: Species
has only substance units: false
name: CPS1

metaR O16G2e
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000176
name: oligo-1,6-glucosidase (strch2 ->strch3), extracellular
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.10
kinetic law: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110012#_1778c94f_2623_4b63_b719_d8b224200784
has only substance units: false
initial amount: NaN
boundary condition: true
is: P28332
name: ADH6
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:130
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110012#_metaR_EX_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1 exchange
type: Reaction

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_0a1e15d3_e7c7_40a6_9a99_7a6e0a7691fa
initial concentration: NaN
initial amount: NaN
is: Q14117
name: DPYS
is encoded by: hsa:1807
type: Species
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110012#_8cf5cf12_a269_47b6_9ce3_5b01000b2347
is: A6NN98
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8898
has only substance units: false
constant: false
name: MTMR2
boundary condition: true
initial concentration: NaN

metaM 5oxpro e
type: Species
name: 5-oxoprolinate
is: HMDB00267
constant: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
initial amount: NaN
is: CHEBI:57606
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaM cdpdag hs m
type: Species
name: CDP-diacylglycerol(2-)
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:58332
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR EX 3bcrn
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy butyryl carnitine
type: Reaction

metaR FAOXC102m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_85decef5_dafc_4421_b85f_5e5fbd9efbc6
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:204
type: Species
has only substance units: false
name: AK2

metaR DM anth
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_86797b72_a03c_4e8b_a8e0_93fadd8217d9
has only substance units: false
type: Species
name: ATP5C1
is: SBO:0000252
constant: false
is: P36542
is encoded by: hsa:509
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_a7cfb4f6_e426_449d_9e1e_5601d2587799
constant: false
initial amount: NaN
is: Q13825
is encoded by: hsa:549
boundary condition: true
has only substance units: false
type: Species
name: AUH
initial concentration: NaN
is: SBO:0000252

metaM c3dc e
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C10H16NO6 CHARGE: -1
initial amount: NaN
name: malonyl carnitine
is: HMDB02095
type: Species
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_53796900_27cb_4879_8d4c_d0c1925ad5b0
name: _AL525798_1_c
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:AL525798
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false

metaR r1938
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is: SBO:0000185
product: MODEL1310110012#
fast: false
modifier: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: false
type: Reaction

metaR r1617
reactant: MODEL1310110012#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000000
product: MODEL1310110012#

metaM cyan c
name: hydrogen cyanide
initial concentration: 1.0
has only substance units: false
is: HMDB02084
constant: false
type: Species
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
initial amount: NaN
is: CHEBI:18407
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_d79f2637_7d22_447a_bc6a_f5f2accf988c
is: SBO:0000252
constant: false
initial concentration: NaN
is: P49247
name: RPIA
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:22934
type: Species

metaM occoa x
is: SBO:0000247
has only substance units: false
is: CHEBI:57386
is: C01944
type: Species
initial concentration: 1.0
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: HMDB01070
boundary condition: false
name: Octanoyl-CoA (n-C8:0CoA)
constant: false
initial amount: NaN

metaM octa e
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C8H15O2 CHARGE: -1
is: CHEBI:25646
is: HMDB00482
initial concentration: 1.0
is: C06423
name: octanoate (n-C8:0)
constant: false

metaM h g
name: proton
is: CHEBI:24636
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

http://identifiers.org/biomodels.db/MODEL1310110012#_ccad170a_e928_45f4_94af_a5141a4ebb99
is: Q9HAS3
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:64078
boundary condition: true
type: Species
name: SLC28A3
constant: false
initial concentration: NaN
has only substance units: false

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

metaR GLYLEUPEPT1tc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_df4fa8e3_efc8_4f99_aae1_b8e44b14c0a6
is encoded by: hsa:53354
type: Species
initial concentration: NaN
name: PANK1
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false

metaR r1616
modifier: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_cf85f895_9062_47c7_ae2d_19dc71981416
is: SBO:0000252
is encoded by: hsa:1808
constant: false
initial concentration: NaN
is: B4DR31
type: Species
boundary condition: true
name: DPYSL2
initial amount: NaN
has only substance units: false

metaM ptdcacrn m
has only substance units: false
name: pendtadenoyl carnitine
is: CHEBI:18303
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false

metaR r0801
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
fast: false
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110012#

metaR DOLPMT U
reversible: false
fast: false
product: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.83
name: Dolichyl-phosphate D-mannosyltransferase (uterus)
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_57f13d79_3fa0_4fc0_86da_6631738c02c3
type: Species
name: DGUOK
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1716
has only substance units: false
boundary condition: true

metaR r0556
reversible: true
reactant: MODEL1310110012#
is: SBO:0000176
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
type: Reaction
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.19.1
modifier: MODEL1310110012#
product: MODEL1310110012#
fast: false

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaM nh4 c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:28938
is: C01342
constant: false
name: Ammonium
has only substance units: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
type: Species
is: HMDB00051
boundary condition: false

metaM gluala e
is: http://identifiers.org/pubchem.compound/6503
name: 5-L-Glutamyl-L-alanine
boundary condition: false
type: Species
is: HMDB06248
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: C03740
initial concentration: 1.0
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740

http://identifiers.org/biomodels.db/MODEL1310110012#_4de00df3_1a03_43af_8b57_5126ba78229b
boundary condition: true
is: Q16853
is: SBO:0000252
is encoded by: hsa:8639
initial amount: NaN
name: AOC3
has only substance units: false
initial concentration: NaN
constant: false
type: Species

metaR COQ5m
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:_2.1.1.- IT
product: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
fast: false
type: Reaction
name: Ubiquinone biosynthesis methyltransferase COQ5
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#

metaM hdcecrn m
type: Species
has only substance units: false
is: HMDB00222
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
name: Hexadecenoyl carnitine
is: SBO:0000247

metaR NAtx
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
product: MODEL1310110012#
fast: false
type: Reaction
reversible: true
name: sodium transport via diffusion (perioxisome)
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#

metaM cyan e
initial amount: NaN
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: SBO:0000247
is: HMDB02084
name: hydrogen cyanide
initial concentration: 1.0
is: CHEBI:18407
boundary condition: false
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_93bed01c_5c7f_49e0_bf06_84c453093974
initial amount: NaN
type: Species
is encoded by: hsa:M68895
boundary condition: true
initial concentration: NaN
name: _M68895_1_c
constant: false
is: SBO:0000252
has only substance units: false

metaM alpa hs c
is: SBO:0000247
has only substance units: false
constant: false
type: Species
notes: FORMULA: C3H6O5PFULLRCO2 CHARGE: -2 INCHI: InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)
name: lysophosphatidic acid
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:52288

metaR r0236
is: SBO:0000176
product: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000000
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.6
reversible: true
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
fast: false
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#

metaM zym int2 r
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
constant: false
has only substance units: false
name: zymosterol intermediate 2
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:52386
is: SBO:0000247

metaR DECDPtm
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:ubiquinone precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
name: lipid, flip-flop intracellular transport
type: Reaction
product: MODEL1310110012#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_4467df51_f082_4988_95a4_56f27e4d88cd
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5337
is: Q59EA4
initial amount: NaN
has only substance units: false
name: PLD1
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_7ee3b16a_9188_4aa7_9fa4_e4d017b8552e
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: P14854
is encoded by: hsa:1340
boundary condition: true
initial amount: NaN
name: COX6B1

metaR DURItn
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110012#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: deoxyuridine transport in nucleus
reactant: MODEL1310110012#
product: MODEL1310110012#
fast: false

metaR 2HBO
fast: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.27
modifier: MODEL1310110012#
reversible: true
is described by: ECO:0000269
is: SBO:0000176
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
type: Reaction

metaM omeprazole e
boundary condition: false
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:7772
notes: FORMULA: C17H19N3O3S CHARGE: 0 INCHI: InChI=1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
name: omeprazole
is: HMDB01913
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_943fcfc5_c6fb_4638_94f1_eede17f07e26
initial amount: NaN
name: PDE7A
is: SBO:0000252
is encoded by: hsa:5150
boundary condition: true
has only substance units: false
type: Species
constant: false
initial concentration: NaN

metaM ptdca c
boundary condition: false
is: http://identifiers.org/pubchem.compound/22169126
initial concentration: 1.0
is: HMDB00826
constant: false
name: pentadecanoate
initial amount: NaN
has only substance units: false
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
is: SBO:0000247
type: Species

metaR CITt4 2
reversible: true
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
type: Reaction
fast: false
kinetic law: MODEL1310110012#
name: citrate transport via sodium symport
modifier: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110012#

metaM pcrn m
boundary condition: false
has only substance units: false
constant: false
is: HMDB00824
initial concentration: 1.0
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: http://identifiers.org/pubchem.compound/107738
type: Species
initial amount: NaN
is: SBO:0000247
name: propionyl-carnitine

http://identifiers.org/biomodels.db/MODEL1310110012#_32b3714a_523f_437e_b918_28084c27536a
is: SBO:0000252
is: Q53TV9
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6120
name: RPE
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_cae2b5f3_2dab_4ee4_8fbd_1b7d2a0dedb7
constant: false
boundary condition: true
initial concentration: NaN
is: P42765
type: Species
is encoded by: hsa:10449
is: SBO:0000252
name: ACAA2
has only substance units: false
initial amount: NaN

metaM nh4 e
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:28938
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
name: ammonium
is: HMDB00051
constant: false

metaR ITCOAL1m
reactant: MODEL1310110012#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
fast: false
modifier: MODEL1310110012#
product: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
is: SBO:0000176
reversible: true

metaR FACOAL161
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase (hexadecenoate)
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
reversible: true
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176

metaM prgnlones c
is: CHEBI:35420
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C21H31O5S CHARGE: -1 INCHI: InChI=1S/C21H32O5S/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19H,5-12H2,1-3H3,(H,23,24,25)/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: CE4764
boundary condition: false
is: HMDB00774
name: pregnenolone sulfate

metaR CSPG Btly
is described by: ECO:0000000
is: SBO:0000185
name: chondroitin sulfate B transport, extracellular to lysosome
kinetic law: MODEL1310110012#
product: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110012#
type: Reaction

metaR INSTt4
reversible: true
reactant: MODEL1310110012#
product: MODEL1310110012#
fast: false
name: inositol transport via sodium symport
modifier: MODEL1310110012#
is described by: ECO:0000269
kinetic law: MODEL1310110012#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD

metaR M13N2Tg
is described by: ECO:0000000
reversible: false
type: Reaction
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.4.1.101
is: SBO:0000176
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
fast: false

metaM cdp c
is: CHEBI:58069
constant: false
has only substance units: false
is: HMDB01546
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: C00112
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: CDP
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_9caaca94_2ce2_4e48_a921_818912bf0507
is: SBO:0000252
name: _NM_013421_1_m
boundary condition: true
constant: false
is encoded by: hsa:NM 013421
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN

metaM ptdca e
name: pentadecanoate
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00826
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/22169126
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)

metaM ksi pre21 g
is: HMDB00175
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
name: keratan sulfate I biosynthesis, precursor 21
is: SBO:0000247
constant: false
type: Species
is: C00130
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:58053
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_d403540c_d0e3_4ac6_9537_b2d0391f6d04
initial amount: NaN
is encoded by: hsa:AI373818
name: _AI373818_1_m
constant: false
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_41d9ee8d_64ff_4e8d_bec4_cfdff47c397e
is: SBO:0000252
is: Q02221
initial concentration: NaN
name: COX6A2
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:1339

http://identifiers.org/biomodels.db/MODEL1310110012#_20874aa8_c5c8_4aa2_8b7b_67c08040bbba
is: Q16706
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4124
constant: false
initial amount: NaN
is: SBO:0000252
name: MAN2A1
type: Species
boundary condition: true

metaR CITt4 4
type: Reaction
name: citrate transport via sodium symport
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
product: MODEL1310110012#
is described by: ECO:0000006
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110012#
fast: false
reactant: MODEL1310110012#

metaR r0553
is: SBO:0000176
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
kinetic law: MODEL1310110012#
reversible: true
product: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
fast: false
is described by: ECO:0000000

metaR GALASE13ly
type: Reaction
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110012#

metaM 3hbcoa R m
constant: false
initial concentration: 1.0
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14-,18-,19-,20+,24-/m1/s1
is: CHEBI:57315
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
name: (R)-3-hydroxybutanoyl-CoA(4-)
initial amount: NaN
is: HMDB01166

metaR DUDPtn
reactant: MODEL1310110012#
is: SBO:0000185
name: dUDP nuclear transport
kinetic law: MODEL1310110012#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110012#_be7911cd_f9e8_44b5_be1d_2007c81a06e9
type: Species
has only substance units: false
name: CYP8B1
initial concentration: NaN
is: SBO:0000252
is: Q9UNU6
boundary condition: true
initial amount: NaN
is encoded by: hsa:1582
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_fcc11641_5ac1_4f59_aa85_8a3cc57a859e
type: Species
initial amount: NaN
constant: false
is: Q13423
name: NNT
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:23530

http://identifiers.org/biomodels.db/MODEL1310110012#_3fc4fb10_2fb8_4b7c_bb55_e83eb6a0e88f
type: Species
name: _T83654_1_e
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:T83654
is: SBO:0000252
constant: false

metaR r1088
product: MODEL1310110012#
name: Active transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#

metaR RE1691M
type: Reaction
reactant: MODEL1310110012#
fast: false
reversible: true
is: SBO:0000176
product: MODEL1310110012#
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.8.1.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
name: RE1691

metaR GALACGLCGALGBSIDEtg
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
name: galacglcgalgbside hs intracellular transport
fast: false
reactant: MODEL1310110012#
is described by: ECO:0000000
product: MODEL1310110012#
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_26d644f4_ed9d_4d37_a7a1_bd5a8a7fe6a7
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:515
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is: SBO:0000297
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_41edb136_6e66_494a_b846_d38e4c8426f3
initial amount: NaN
name: SLCO4A1
is encoded by: hsa:28231
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is: Q96BD0
constant: false
initial concentration: NaN

metaM dhea c
type: Species
initial amount: NaN
boundary condition: false
constant: false
name: 3beta-hydroxyandrost-5-en-17-one
is: CHEBI:28689
is: HMDB00077
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_83bc463c_81c2_49e4_8c19_8e7f1f62e331
name: LHPP
boundary condition: true
is: Q9H008
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:64077
initial amount: NaN

metaM CE5117 m
is: CHEBI:57923
initial concentration: 1.0
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
constant: false
type: Species
boundary condition: false
has only substance units: false

metaR C226CRNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
fast: false
kinetic law: MODEL1310110012#
type: Reaction
is: SBO:0000185
product: MODEL1310110012#
reactant: MODEL1310110012#
reversible: false
is described by: ECO:0000000
name: C226 transport into the mitochondria

metaM pail345p hs c
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
is: CHEBI:57836
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR r1944
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reactant: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110012#

metaR NAGA2ly
kinetic law: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
type: Reaction
product: MODEL1310110012#
name: N-acetylgalactosaminidase, alpha-
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.49
is: SBO:0000176
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_a0221f91_e0fc_4daa_aefe_1804259b02fd
initial concentration: NaN
is: SBO:0000252
is: P05496
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: ATP5G1
is encoded by: hsa:516
boundary condition: true

metaR r0559
type: Reaction
reactant: MODEL1310110012#
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
modifier: MODEL1310110012#
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.5.1.3
kinetic law: MODEL1310110012#
is: SBO:0000176

metaR PRO1xm
is described by: ECO:0000254
kinetic law: MODEL1310110012#
fast: false
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD
type: Reaction
name: proline oxidase (NAD), mitochondrial
is: SBO:0000176
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.5.99.8
reactant: MODEL1310110012#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110012#_93a5b3ff_82ff_4aba_8439_bb8fece8d27a
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:N63787
name: _N63787_1_c
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_5936469f_29f6_44f9_874b_2dd9a02cd628
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:277
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: AMY1B
constant: false
is: P04745

metaR AMANK
name: N-acetyl-D-mannosamine kinase
product: MODEL1310110012#
is described by: ECO:0000269
reactant: MODEL1310110012#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.1.3.14
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES:JLR - Kegg R02705
is version of: http://identifiers.org/ec-code/2.7.1.59
kinetic law: MODEL1310110012#
fast: false
reversible: false
type: Reaction

metaM cmusa c
is: C04409
is: CHEBI:994
constant: false
is: SBO:0000247
type: Species
name: cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C7H6NO5 CHARGE: -1 INCHI: InChI=1S/C7H7NO5/c8-5(7(12)13)4(6(10)11)2-1-3-9/h1-3H,8H2,(H,10,11)(H,12,13)/p-2/b2-1-,5-4- HEPATONET_1.0_ABBREVIATION: HC01288 EHMN_ABBREVIATION: C04409

metaR CITtam
is: SBO:0000185
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
reactant: MODEL1310110012#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110012#
reversible: true
name: citrate transport, mitochondrial
type: Reaction
product: MODEL1310110012#

metaR FE3MTP1
kinetic law: MODEL1310110012#
is described by: ECO:0000134
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
fast: false
name: transport of ferrous iron into blood
reactant: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_16a45554_831b_4b72_b636_58dc146c1733
has only substance units: false
is: P00813
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: ADA
constant: false
type: Species
is encoded by: hsa:100

http://identifiers.org/biomodels.db/MODEL1310110012#_ae9e6601_248c_4600_bb9c_b5c1dce33824
name: NAGK
is: Q9UJ70
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:55577
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_cf130fc4_0ea1_4acc_9fcd_c9fa116d72ef
is encoded by: hsa:3032
initial concentration: NaN
constant: false
type: Species
boundary condition: true
initial amount: NaN
is: P55084
has only substance units: false
is: SBO:0000252
name: HADHB

metaR UMPKn
type: Reaction
product: MODEL1310110012#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110012#
is described by: ECO:0000269
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
name: UMP kinase, nuclear
reversible: true
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM hpdcacoa m
has only substance units: false
initial amount: NaN
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
name: heptadecanoyl coa
constant: false
initial concentration: 1.0
is: HMDB06497
type: Species
is: SBO:0000247
boundary condition: false

metaR DGULND
type: Reaction
reactant: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000176
name: dehydro-L-gulonate decarboxylase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
kinetic law: MODEL1310110012#
fast: false
reversible: true
is described by: ECO:0000000

metaR SUCCOAPET
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaR r0558
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110012#
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.3
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reactant: MODEL1310110012#

metaR DDECCRNe
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of lauroyl carnitine into extra cellular space
type: Reaction

metaR EX 3aib LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-3-Amino-isobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_2a0b09d0_3d67_42e3_aad3_85bf6f1a0104
constant: false
is: Q5T4W8
boundary condition: true
name: ST3GAL3
initial concentration: NaN
is encoded by: hsa:6487
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false

metaR OBDHc
name: 2-Oxobutanoate dehydrogenase, cytosolic
product: MODEL1310110012#
reversible: false
fast: false
reactant: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.7.2 Confidence Level: 2 AUTHORS: NOTES:as shown in Lehninger (4th ed.) for threonine degradation MM
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110012#

metaR INSt
type: Reaction
fast: false
reactant: MODEL1310110012#
reversible: true
is: SBO:0000185
modifier: MODEL1310110012#
product: MODEL1310110012#
name: Inosine transport (diffusion)
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
kinetic law: MODEL1310110012#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110012#_f8472bd6_d4eb_4373_860b_61c51724a492
type: Species
name: PLA2G2A
has only substance units: false
is: SBO:0000252
is: P14555
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:5320
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_daef61b5_f1f7_412c_9210_4b81fe7d835b
is: Q9UBK5
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: HCST
boundary condition: true
type: Species
is encoded by: hsa:10870

metaR GLCNACASE5ly
reactant: MODEL1310110012#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
product: MODEL1310110012#
type: Reaction
reversible: false
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.50
modifier: MODEL1310110012#
is: SBO:0000176
name: alpha-N-acetylglucosaminidase, lysosomal

metaM tdec4ecoa m
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
name: trans4decenoylcoa
initial concentration: 1.0
initial amount: NaN
is: HMDB00792
has only substance units: false
is: SBO:0000247
boundary condition: false
is: C08277
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_c23ec4e2_3d3b_45b6_8d29_440fe55405c6
has only substance units: false
name: LDHAL6B
initial amount: NaN
boundary condition: true
is: Q9BYZ2
is encoded by: hsa:92483
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252

metaM HC01403 m
has only substance units: false
name: (S)-Hydroxydecanoyl-CoA
initial concentration: 1.0
is: CHEBI:28325
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_0fffa306_2e75_453c_ae14_5f2196cd3134
is encoded by: hsa:5464
has only substance units: false
type: Species
is: Q15181
constant: false
name: PPA1
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_dcefb327_85d0_4bcf_9fa8_c0f25ed05781
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: H0UI06
is: SBO:0000252
is encoded by: hsa:1347
name: COX7A2
has only substance units: false
type: Species

metaR NACHEXA21ly
reversible: false
reactant: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
name: beta-N-acetylhexosaminidase A, lysosomal
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110012#_e4e00ed8_7e9a_44ea_88d0_da56240238d0
is: P23368
initial amount: NaN
type: Species
name: ME2
constant: false
has only substance units: false
is encoded by: hsa:4200
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM omeprazole c
boundary condition: false
notes: FORMULA: C17H19N3O3S CHARGE: 0 INCHI: InChI=1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
constant: false
name: omeprazole
is: CHEBI:7772
initial concentration: 1.0
initial amount: NaN
is: HMDB01913
type: Species
has only substance units: false
is: SBO:0000247

metaR FUT18g
modifier: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110012#
name: Galactoside 2-alpha-L-fucosyltransferase 1
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.69
is: SBO:0000176
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ

metaR S6TASE23ly
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110012#
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110012#
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110012#_603dd6bd_c021_49ad_b014_c547c9645fd3
is: Q9Y2A9
name: B3GNT3
constant: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10331

metaR ABUTt2r
is: SBO:0000185
product: MODEL1310110012#
type: Reaction
reversible: true
modifier: MODEL1310110012#
name: 4-aminobutyrate reversible transport in via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
fast: false
kinetic law: MODEL1310110012#
is described by: ECO:0000304
reactant: MODEL1310110012#

metaM xol7ah2 m
is: HMDB06893
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
type: Species
is: CHEBI:28047
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha-diol

metaR PPM
reversible: true
product: MODEL1310110012#
name: phosphopentomutase
type: Reaction
modifier: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5236.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/5.4.2.2
kinetic law: MODEL1310110012#
is: SBO:0000176
fast: false

metaR r0669
reactant: MODEL1310110012#
reversible: false
is described by: ECO:0000000
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
fast: false
product: MODEL1310110012#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
kinetic law: MODEL1310110012#

metaM c81coa c
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: C05276
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
is: HMDB03949
name: octenoylcoa
is: SBO:0000247
initial concentration: 1.0

metaM g1m8masn r
boundary condition: false
is: SBO:0000247
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: C05875
notes: FORMULA: C76H127N2O60X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110012#_08dfbb48_ad57_4ac9_9901_4dbf0ec466f1
constant: false
boundary condition: true
is: P32321
is encoded by: hsa:1635
type: Species
has only substance units: false
is: SBO:0000252
name: DCTD
initial amount: NaN
initial concentration: NaN

metaR HAtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
name: hyaluronan transport, extracellular to lysosome
product: MODEL1310110012#
type: Reaction

metaR r0809
is described by: ECO:0000000
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
product: MODEL1310110012#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
name: Facilitated diffusion
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:
reactant: MODEL1310110012#
is: SBO:0000185
type: Reaction

metaM strdnc c
has only substance units: false
initial amount: NaN
name: stearidonic acid C18:4, n-3
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205608
is: HMDB06547
is: C16300
constant: false
is: SBO:0000247
boundary condition: false

metaR NAGLCAly
reversible: false
is: SBO:0000176
product: MODEL1310110012#
is described by: ECO:0000000
reactant: MODEL1310110012#
name: N-acetylglucosaminidase, lysosomal
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_ffc92251_622c_4d24_af05_2980ee11e813
is: SBO:0000252
is encoded by: hsa:5169
name: ENPP3
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: Q308M7
boundary condition: true
constant: false

metaR Asn X Ser Thrtr
fast: false
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
is described by: ECO:0000269
type: Reaction
name: Asn-X-Ser/Thr transport (from ER to lysosome)
kinetic law: MODEL1310110012#
reversible: true
product: MODEL1310110012#
is: SBO:0000185

metaM mi34p c
boundary condition: false
is: CHEBI:28858
is: HMDB06235
constant: false
has only substance units: false
name: 1D-myo-Inositol 3,4-bisphosphate
type: Species
is: SBO:0000247
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C04063
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_3c410b6d_6fd6_4560_9cd1_00e5c9e5a932
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
name: XDH
is: P47989
is: SBO:0000252
is encoded by: hsa:7498

metaR ACNACNGALGBSIDEte
is: SBO:0000185
reactant: MODEL1310110012#
fast: false
name: acnacngalgbside hs transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
kinetic law: MODEL1310110012#
reversible: true
product: MODEL1310110012#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110012#_f7a20b17_46aa_4a40_a55d_34ae04c36b58
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:114
type: Species
is: Q4F7X0
initial concentration: NaN
constant: false
is: SBO:0000252
name: ADCY8

metaR r0668
fast: false
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
modifier: MODEL1310110012#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.2.19
kinetic law: MODEL1310110012#
reversible: true
reactant: MODEL1310110012#
is: SBO:0000176
type: Reaction

metaM cdpdag hs c
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:58332
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: CDP-diacylglycerol(2-)
constant: false

metaM cyan m
name: hydrogen cyanide
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB02084
type: Species
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: CHEBI:18407
initial amount: NaN
constant: false
boundary condition: false

metaR DESAT18 4
reversible: false
reactant: MODEL1310110012#
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.14.19.1
fast: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110012#_7892ed41_aba0_4579_aff4_3ad0df336f65
name: ACAA2
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P42765
initial concentration: NaN
type: Species
is encoded by: hsa:10449

metaR DNDPt11m
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
kinetic law: MODEL1310110012#
name: dADP transport via dGDP antiport
is described by: ECO:0000269
fast: false
reactant: MODEL1310110012#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110012#

metaM leuktrB4 c
initial concentration: 1.0
initial amount: NaN
type: Species
name: leukotriene B4(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: HMDB01085
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:57461
is: SBO:0000247

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaR IDPtn
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110012#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
name: IDP nuclear transport

http://identifiers.org/biomodels.db/MODEL1310110012#_4fe8e1ac_e127_471d_b240_0efcbbf9de23
initial amount: NaN
boundary condition: true
is encoded by: hsa:6822
is: Q06520
name: SULT2A1
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false

metaR r0122
type: Reaction
fast: false
product: MODEL1310110012#
name: GTP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110012#
reversible: false
reactant: MODEL1310110012#

metaR LGNCt
product: MODEL1310110012#
fast: false
name: fatty acid transport via diffusion
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaM gd3 hs g
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
initial concentration: 1.0
type: Species
is: CHEBI:28424
name: GD3

http://identifiers.org/biomodels.db/MODEL1310110012#_07fdadbf_dfa4_4190_89d3_5daf04713990
is: O15327
type: Species
name: INPP4B
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:8821

http://identifiers.org/biomodels.db/MODEL1310110012#_8afec175_1cb2_465c_938b_358278628bce
initial amount: NaN
constant: false
is encoded by: hsa:AI640625
initial concentration: NaN
name: _AI640625_1_c
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR PIK3
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.154
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.1.137
kinetic law: MODEL1310110012#
name: phosphatidylinositol 3-kinase
is described by: ECO:0000000
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000176
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
reversible: false

metaR GALACGLCGALGBSIDEte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reversible: true
name: galacglcgalgbside hs transport
reactant: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110012#
fast: false
is: SBO:0000185
product: MODEL1310110012#

metaR PROSTGE2t
kinetic law: MODEL1310110012#
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
is: SBO:0000185
reactant: MODEL1310110012#
product: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
fast: false
is described by: ECO:0000269
modifier: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_14123b06_cdfc_4e37_9b53_7bbb90d42fad
initial concentration: NaN
is: SBO:0000252
is: B4DYG5
constant: false
is encoded by: hsa:5297
has only substance units: false
initial amount: NaN
name: PI4KA
boundary condition: true
type: Species

metaR PIt8
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
product: MODEL1310110012#
name: phosphate transport in/out via Na+ symporter
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000185
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110012#
is described by: ECO:0000006

metaR FAOXC102x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)x
type: Reaction

metaM nh4 m
is: HMDB00051
has only substance units: false
is: C01342
name: Ammonium
is: CHEBI:28938
constant: false
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_073e30f8_9723_4506_a3db_758e4bcff8f6
is encoded by: hsa:2592
initial amount: NaN
is: E7ET32
name: GALT
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM pcrn c
initial concentration: 1.0
is: HMDB00824
initial amount: NaN
constant: false
is: SBO:0000247
name: propionyl-carnitine
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/107738
boundary condition: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3

http://identifiers.org/biomodels.db/MODEL1310110012#_6d610dff_1965_4159_a60d_5c1bcf27cc12
name: _AI620219_1_c
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI620219
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_0a03a44d_4a35_4eea_888c_47cc4f7c2952
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:AI539321
initial concentration: NaN
initial amount: NaN
name: _AI539321_1_c

metaM hdca e
initial concentration: 1.0
is: HMDB00220
is: C00249
is: CHEBI:0
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C16H31O2 CHARGE: -1
name: Hexadecanoate (n-C16:0)
is: SBO:0000247
type: Species
initial amount: NaN

metaR CAROtr
is: SBO:0000185
reactant: MODEL1310110012#
name: beta-carotene transport via diffusion
reversible: true
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110012#
type: Reaction
fast: false
is described by: ECO:0000000

metaR GALASE6ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110012#
is described by: ECO:0000000
fast: false
name: beta-galactosidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110012#

metaR LPS
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: false
name: lipase
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:carbonyl and extra H accounted for in R group NJ
is version of: http://identifiers.org/ec-code/3.1.1.34
product: MODEL1310110012#

metaR ARGtm
reversible: true
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
fast: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000269
name: arginine mitochondrial transport via ornithine carrier
reactant: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction

metaM c10dc x
notes: FORMULA: C17H30NO6 CHARGE: -1
name: sebacoyl carnitine
initial concentration: 1.0
type: Species
is: HMDB00651
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_615f072a_ed89_409d_b395_9baf6ec76b4a
type: Species
initial concentration: NaN
constant: false
boundary condition: true
name: _HG2846_HT2983_1_c
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:HG2846-HT2983

http://identifiers.org/biomodels.db/MODEL1310110012#_c40506ad_539e_48c5_adbf_a11929f820ee
is: SBO:0000252
is: P33897
name: ABCD1
boundary condition: true
type: Species
is encoded by: hsa:215
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM m6masnC g
is: CHEBI:30825
is: SBO:0000247
is: HMDB00573
boundary condition: false
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C58H97N2O45X CHARGE: 0
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaM strdnc e
initial amount: NaN
has only substance units: false
is: HMDB06547
is: http://identifiers.org/pubchem.compound/47205608
name: stearidonic acid C18:4, n-3
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: C16300
is: SBO:0000247
boundary condition: false

metaM occoa c
is: C01944
constant: false
boundary condition: false
name: Octanoyl-CoA (n-C8:0CoA)
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: SBO:0000247
is: HMDB01070
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:57386
initial amount: NaN

metaM vacc e
constant: false
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:30828
name: trans-vaccenate
has only substance units: false

metaR PIt7
product: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
name: phosphate transport in/out via three Na+ symporter
modifier: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
reversible: true

metaR ACNACNGALGBSIDEtg
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
product: MODEL1310110012#
name: acnacngalgbside hs intracellular transport
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#

metaR TXASr
is: SBO:0000176
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
reactant: MODEL1310110012#
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/5.3.99.5
product: MODEL1310110012#
name: Thromboxane-A synthase
is described by: ECO:0000134

metaM pail34p hs c
has only substance units: false
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
initial amount: NaN
is: CHEBI:57658
boundary condition: false

metaM nh4 n
is: HMDB00051
name: ammonium
has only substance units: false
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species

metaR r0666
is: SBO:0000176
reversible: true
type: Reaction
kinetic law: MODEL1310110012#
is described by: ECO:0000000
product: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
fast: false
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
is version of: http://identifiers.org/ec-code/1.2.4.2
reactant: MODEL1310110012#

metaR FAOXC6C4x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6-->C4)x
type: Reaction

metaR FUCASEe
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.51
type: Reaction
reversible: false
product: MODEL1310110012#
is described by: ECO:0000000
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
name: alpha-fucosidase, extracellular
fast: false
reactant: MODEL1310110012#
is: SBO:0000176

metaM 13dpg c
type: Species
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
has only substance units: false
constant: false
is: HMDB01270
name: 3-Phospho-D-glyceroyl phosphate
initial amount: NaN
is: C00236
is: http://identifiers.org/pubchem.compound/3535
is: CHEBI:57604
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_a2df730a_46a9_4fc6_b4d4_bd2a32a69e86
type: Species
name: PIGP
has only substance units: false
initial amount: NaN
is: P57054
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:51227
constant: false
boundary condition: true

metaM thr L c
has only substance units: false
type: Species
name: L-threonine
initial concentration: 1.0
is: CHEBI:16857
is: HMDB00167
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: SBO:0000247

metaR DESAT18 6
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
product: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
name: fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
kinetic law: MODEL1310110012#
is described by: ECO:0000269
reversible: false
fast: false
is: SBO:0000176
reactant: MODEL1310110012#

metaM leuktrB4 e
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB01085
name: leukotriene B4(1-)
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57461

http://identifiers.org/biomodels.db/MODEL1310110012#_b57d8548_5ad1_4696_bfa2_ec5997bff07e
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: PDE6B
constant: false
is: B7Z9T9
initial concentration: NaN
is encoded by: hsa:5158
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_8e8fc076_ee39_4e92_86b0_91e68d95e09d
type: Species
name: PCBD1
is encoded by: hsa:5092
is: P61457
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN

metaR G6PDA
reversible: false
reactant: MODEL1310110012#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.99.6
fast: false
notes: GENE_ASSOCIATION: (132789.1) or (10007.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.99.6 Confidence Level: 4 AUTHORS: PMID:9714720 NOTES:Previously EC 5.3.1.10
kinetic law: MODEL1310110012#
type: Reaction
name: glucosamine-6-phosphate deaminase
is: SBO:0000176
product: MODEL1310110012#
modifier: MODEL1310110012#

metaM 4mlacac c
is: CHEBI:17105
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
initial amount: NaN
name: 4-maleylacetoacetate
type: Species
constant: false
is: HMDB02052
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR H2Otg
reversible: true
name: H2O transport, Golgi apparatus
fast: false
reactant: MODEL1310110012#
is: SBO:0000185
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110012#

metaM 10fthf e
name: 10-formyltetrahydrofolate(2-)
boundary condition: false
is: CHEBI:57454
initial amount: NaN
is: SBO:0000247
is: HMDB00972
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
has only substance units: false
type: Species
constant: false
initial concentration: 1.0

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_ac993598_c6a0_417f_a90e_f0605880a36b
type: Species
is encoded by: hsa:412
initial amount: NaN
is: SBO:0000252
name: STS
initial concentration: NaN
boundary condition: true
constant: false
is: P08842
has only substance units: false

metaM man1p c
initial amount: NaN
is: CHEBI:35374
is: HMDB06330
is: SBO:0000247
name: D-Mannose 1-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
constant: false
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaM prpncoa m
is: SBO:0000247
is: CHEBI:57367
boundary condition: false
type: Species
is: HMDB02307
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
name: acryloyl-CoA(4-)
constant: false

metaM hdca c
name: palmitate
constant: false
initial amount: NaN
is: HMDB00220
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
has only substance units: false
is: CHEBI:7896

metaM dudp n
is: HMDB01000
initial concentration: 1.0
initial amount: NaN
name: dUDP(3-)
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
constant: false
is: CHEBI:60471

http://identifiers.org/biomodels.db/MODEL1310110012#_metaM_acglc13galacglcgal14acglcgalgluside_hs_g
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: nLc7Cer
constant: false
is: CHEBI:26174
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0

metaR C51CPT1
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tiglylcarnitine
type: Reaction

metaR S4TASE3ly
modifier: MODEL1310110012#
is described by: ECO:0000000
product: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
fast: false
kinetic law: MODEL1310110012#
reversible: true
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.12
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD

metaM tsul m
constant: false
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00257
is: CHEBI:16094
initial concentration: 1.0
type: Species
name: thiosulfate(2-)
is: SBO:0000247

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaM hexdectecoa m
has only substance units: false
constant: false
name: 2,4,7,10-hexadecatetraenoylcoa
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB02288

metaR GGH 10FTHF6GLUe
reversible: false
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
is: SBO:0000176
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
product: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false

metaM cholp c
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: choline phosphate(1-)
is: CHEBI:295975
constant: false

metaR G6PPer
kinetic law: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (57818.1) or (2538.1) or (92579.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.9 Confidence Level: 4 AUTHORS: PMID:10078553,PMID:11297555,PMID:12370122,PMID:12965222,PMID:13129915,PMID:15044018,PMID:8211187,PMID:8407995,PMID:9497333 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.9
reversible: false
name: glucose-6-phosphate phosphatase, edoplasmic reticular

metaR SFGTH
is: SBO:0000176
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
fast: false
kinetic law: MODEL1310110012#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.2.12
reactant: MODEL1310110012#
product: MODEL1310110012#
reversible: true
type: Reaction
modifier: MODEL1310110012#
name: S-Formylglutathione hydralase

http://identifiers.org/biomodels.db/MODEL1310110012#_62e4349e_4989_4ac1_b5e1_23e9ea0836eb
has part: P15531
type: Species
constant: false
is encoded by: hsa:4830
has only substance units: false
is: SBO:0000297
name: NME1:NME2
initial amount: NaN
boundary condition: true
is encoded by: hsa:4831
has part: P22392
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_ecf00912_9c9e_486a_a0a8_db644086d47a
initial concentration: NaN
has only substance units: false
is: SBO:0000297
boundary condition: true
initial amount: NaN
is encoded by: hsa:8310
name: EHHADH:ACAA1:HSD17B4:ACOX3
has part: O15254
constant: false
type: Species

metaR PROGLYPEPT1tc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Prolylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR RE2069C
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
product: MODEL1310110012#
name: RE2069

metaR DOLPMT4 Uer
is described by: ECO:0000000
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
reversible: false
reactant: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110012#

metaM fpram c
constant: false
boundary condition: false
has only substance units: false
is: HMDB06211
is: C04640
initial amount: NaN
is: CHEBI:58478
type: Species
initial concentration: 1.0
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
is: SBO:0000247

metaM lneldc e
is: HMDB06270
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: linoelaidic acid (all trans C18:2)
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+

metaM thr L e
is: SBO:0000247
is: CHEBI:16857
has only substance units: false
name: L-threonine
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00167
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
type: Species
boundary condition: false

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaR r1487
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110012#
product: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: true
is described by: ECO:0000000
name: EC:6.2.1.3
is: SBO:0000176

metaR SUCCCROT
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of succinyl carnitine
type: Reaction

metaR AG13T8g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110012#
reversible: false
product: MODEL1310110012#
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110012#

metaM dhcholoylcoa x
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
is: HMDB06895
initial amount: NaN
is: CHEBI:27393
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA
constant: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_49d323e8_fa0d_42d1_a0cc_6ea979b440cb
name: SHMT2
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6472
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: B4DJQ3
type: Species

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaM 10fthf c
name: 10-Formyltetrahydrofolate
boundary condition: false
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: HMDB00972
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: C00234
initial concentration: 1.0
type: Species
constant: false

metaM 4mzym int1 r
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
has only substance units: false
is: HMDB06927
type: Species
name: 4-Methylzymosterol intermediate 1
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_1ab7bedd_9bf4_4633_aa8a_01df638af5db
boundary condition: true
initial concentration: NaN
name: SRM
is: SBO:0000252
initial amount: NaN
is: P19623
has only substance units: false
is encoded by: hsa:6723
type: Species
constant: false

metaR G14T16g
type: Reaction
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110012#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
modifier: MODEL1310110012#

metaR NDPK4n
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
product: MODEL1310110012#
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
fast: false
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110012#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110012#_d2031849_dca9_4005_9979_4e6376ffc97f
is: P23743
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:1606
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
name: DGKA

metaM dctp c
is: C00458
is: HMDB00998
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:16311
is: SBO:0000247
name: dCTP
initial amount: NaN
type: Species
constant: false

metaR CYTK4n
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
reactant: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000176
name: cytidylate kinase (dCMP,GTP),nuclear
type: Reaction
fast: false
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaR FAOXC8C6x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)x
type: Reaction

metaR ACETONEt2
reactant: MODEL1310110012#
name: acetone transport via proton symport
fast: false
reversible: true
is described by: ECO:0000269
product: MODEL1310110012#
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD

metaM lneldc c
initial concentration: 1.0
is: HMDB06270
type: Species
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
name: linoelaidic acid (all trans C18:2)
initial amount: NaN

metaR FAOXC102C101m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaM dudp m
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
constant: false
name: dUDP(3-)
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:60471
is: HMDB01000
initial concentration: 1.0

metaM h x
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
is: C00080
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
type: Species
is: CHEBI:24636
name: proton
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_0607c5e5_9a84_47d6_801c_4a07b722afef
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:4842
is: B4DG68
boundary condition: true
name: NOS1

metaR 4HBZFm
reversible: false
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
is: SBO:0000176
product: MODEL1310110012#
fast: false
type: Reaction
name: 4-hydroxybenzoate formation

http://identifiers.org/biomodels.db/MODEL1310110012#_8950550a_420c_4bb9_b3cb_c7c92c3ae652
is: SBO:0000252
type: Species
boundary condition: true
name: AK1
has only substance units: false
is encoded by: hsa:203
is: P00568
initial concentration: NaN
constant: false
initial amount: NaN

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaR APPNNte
type: Reaction
reactant: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, xenobiotic transport (original and metabolized) NJ
product: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000185
name: xenobiotic transport
reversible: true
kinetic law: MODEL1310110012#

metaM utp e
is: CHEBI:46398
boundary condition: false
initial amount: NaN
has only substance units: false
name: UTP(4-)
type: Species
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
constant: false
is: HMDB00285
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_26ba1cb8_ec03_4f6f_b729_95b0ef4069da
is encoded by: hsa:1718
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: DHCR24
initial amount: NaN
constant: false
type: Species
is: Q15392
boundary condition: true

metaR H2Otp
product: MODEL1310110012#
reversible: true
name: H2O transport, peroxisomal
reactant: MODEL1310110012#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110012#

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaM cs b deg2 l
initial concentration: 1.0
notes: FORMULA: C37H54NO41S3 CHARGE: -5
has only substance units: false
is: CHEBI:16953
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00812
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_58308cff_96a8_4ca0_81aa_02fe7db60943
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6240
initial amount: NaN
type: Species
boundary condition: true
name: RRM1
constant: false
is: P23921

metaR EX 34hpp
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaR r1600
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110012#
kinetic law: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185

metaR FATP6t
product: MODEL1310110012#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
is described by: ECO:0000269
name: fatty acid electroneutral transport
reactant: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is version of: http://identifiers.org/ec-code/6.2.1.7
type: Reaction

metaR C4tmc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine into mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_05a5c79d_40e3_433b_8c6b_fa8c96468a9c
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2678
constant: false
name: GGT1
initial amount: NaN
is: P19440
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_87c4651c_16d2_4e8a_98b7_e2b4d5ae0c67
has part: O00459
initial concentration: NaN
has part: P42336
initial amount: NaN
is encoded by: hsa:5296
is encoded by: hsa:5290
boundary condition: true
name: PIK3CA:PIK3R2
has only substance units: false
is: SBO:0000297
type: Species
constant: false

metaR FAOXC102C101x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:1)x
type: Reaction

metaR RE1526M
reactant: MODEL1310110012#
reversible: true
modifier: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1526
kinetic law: MODEL1310110012#

metaM na1 c
is: SBO:0000247
is: CHEBI:4541
boundary condition: false
is: HMDB00588
constant: false
has only substance units: false
notes: FORMULA: Na CHARGE: 1
type: Species
is: C01330
name: Sodium
initial concentration: 1.0
initial amount: NaN

metaR r0671
is: SBO:0000176
name: (R)-4-Phosphopantothenate:L-cysteine ligase EC:6.3.2.5
notes: GENE_ASSOCIATION: (2717.1) or (6173.1) SUBSYSTEM: CoA synthesis EC Number: 6.3.2.5 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:12906824,PMID:15893380 NOTES:
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.22
fast: false
product: MODEL1310110012#

metaM ocdcea r
is: HMDB00207
name: octadecenoate (n-C18:1)
notes: FORMULA: C18H33O2 CHARGE: -1
constant: false
is: SBO:0000247
is: C00712
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:0

metaM lpchol hs e
constant: false
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: lysophosphatidylcholine
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:60479

metaR GLNSERNaEx
reversible: false
kinetic law: MODEL1310110012#
name: L-serine/L-glutamine Na-dependent exchange (Gln-L in)
is: SBO:0000185
reactant: MODEL1310110012#
modifier: MODEL1310110012#
fast: false
is described by: ECO:0000269
product: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

http://identifiers.org/biomodels.db/MODEL1310110012#_91c72b64_d3ea_47de_90a4_21c579325f9b
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: HSD3B1
boundary condition: true
has only substance units: false
is: P14060
type: Species
is encoded by: hsa:3283

MODEL1310110012#
species: metaM gdpfuc c
species: metaM dlnlcgcrn c
species: metaM adrncrn m
species: metaM q10h2 c
species: metaM c8dc c
species: metaM CE5868 e
species: metaM hexdicoa c
species: metaM adp c
species: metaM c10crn e
species: metaM ficytC m
species: metaM estrone c
species: metaM Asn X Ser Thr r
species: metaM 5mta c
species: metaM ksii core4 e
species: metaM malttr e
species: metaM asn L m
species: metaM L2aadp6sa c
species: metaM creat e
species: metaM 2dr1p c
species: metaM csn e
species: metaM 5mthf c
species: metaM HC01434 x
species: metaM hs deg23 l
species: metaM itaccoa m
species: metaM cgly e
species: metaM ctp c
species: metaM cyan e
species: metaM adrncoa x
species: metaM ksi pre31 g
species: metaM tetpent3 c
species: metaM 4hpro LT c
species: metaM 5oxpro c
species: metaM pi m
species: metaM srtn c
species: metaM glu5p m
species: metaM g6p c
species: metaM odecrn m
species: metaM thcholoylcoa x
species: metaM doldp U r
species: metaM HC02204 e
species: metaM 3mox4hpac m
species: metaM didp n
species: metaM l2n2m2mn l
species: metaM c16dc e
species: metaM gly x
species: metaM cl e
species: metaM xylu D c
species: metaM retinal cis 13 r
species: metaM no e
species: metaM glyc R c
species: metaM progly c
species: metaM HC02216 c
species: metaM bilglcur r
species: metaM hxcoa x
species: metaM CE2838 e
species: metaM 34dhmald c
species: metaM s2l2n2m2mn l
species: metaM 5adtststerones c
species: metaM hspg l
species: metaM spc hs e
species: metaM octe5coa x
species: metaM retinol c
species: metaM succoa c
species: metaM eitetcoa x
species: metaM lnlc c
species: metaM sgalside hs l
species: metaM 3hexdtricoa x
species: metaM asp L c
species: metaM CE2917 e
species: metaM fadh2 c
species: metaM dag hs c
species: metaM ha e
species: metaM fmn c
species: metaM decdicrn e
species: metaM galside hs c
species: metaM dhap c
species: metaM dd5ecoa m
species: metaM aacoa m
species: metaM but e
species: metaM HC02203 c

metaR r0119
is: SBO:0000176
reactant: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/5.1.3.14
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110012#_0050f8a3_508e_462d_b47f_2d59b80e4051
name: GLA
is: Q53Y83
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2717

metaM 2dp6mobq m
notes: FORMULA: C57H86O3 CHARGE: 0 INCHI: InChI=1S/C57H86O3/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58)43-56(60-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
type: Species
name: 2-decaprenyl-6-methoxy-1,4-benzoquinone
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:50773

metaR FAOXC8C6m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_db77a58b_6f45_487f_ba41_1ed24d97a5f7
has only substance units: false
type: Species
is encoded by: hsa:6576
is: D9HTE9
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: SLC25A1
initial amount: NaN

metaR AG13T6g
reactant: MODEL1310110012#
is: SBO:0000176
kinetic law: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110012#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
type: Reaction
reversible: false
modifier: MODEL1310110012#

metaM lnlncgcoa r
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
constant: false
is: HMDB06368
name: gamma-linolenoyl-CoA(4-)
boundary condition: false
is: CHEBI:57363

metaM utp c
is: CHEBI:46398
type: Species
name: UTP
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: C00075
is: HMDB00285
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM apoC c
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
name: Apocarboxlase (no lys residue)
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
is: SBO:0000247
is: CHEBI:29060
has only substance units: false
is: HMDB03667

metaR r0672
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
is: SBO:0000176
product: MODEL1310110012#
fast: false
modifier: MODEL1310110012#
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#

metaR PSDm hs
is described by: ECO:0000269
type: Reaction
name: Phosphatidylserine decarboxylase
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.65
product: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ

http://identifiers.org/biomodels.db/MODEL1310110012#_4f1822c4_7a67_4dec_ad69_7bc4a69461b1
boundary condition: true
is encoded by: hsa:8790
initial concentration: NaN
name: FPGT
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: O14772
constant: false

metaM ksi deg31 l
name: keratan sulfate I, degradation product 31
notes: FORMULA: C90H148N6O72S2 CHARGE: -2
boundary condition: false
is: HMDB00812
has only substance units: false
is: CHEBI:16953
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_d1f3dcec_0541_4fc6_9bf8_48d4afb24e9e
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: _D29675_1_e
is encoded by: hsa:D29675
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_98ac69ed_2bce_49f3_889d_6ae576166863
constant: false
name: ABCB4
has only substance units: false
is: A4D1D5
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:5244
initial amount: NaN
initial concentration: NaN

metaM odecoa r
is: HMDB01322
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
initial concentration: 1.0
is: CHEBI:57387
name: oleoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110012#_1e5714ec_f779_4f42_a5e4_36d21273aa1f
type: Species
is: SBO:0000252
name: _AI824319_1_r
constant: false
is encoded by: hsa:AI824319
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR RE3001M
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110012#
fast: false
modifier: MODEL1310110012#
is: SBO:0000176
product: MODEL1310110012#
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.3.1.34
name: RE3001

metaM CE1935 e
is: HMDB02329
boundary condition: false
notes: FORMULA: C10H26N3O CHARGE: 3 INCHI: InChI=1/C10H23N3O/c11-5-3-8-12-6-1-2-7-13-9-4-10-14/h10,12-13H,1-9,11H2/p+3 EHMN_ABBREVIATION: CE1935
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:30623
constant: false
type: Species
initial amount: NaN
has only substance units: false
name: spermine monoaldehyde

http://identifiers.org/biomodels.db/MODEL1310110012#_5f1ff9a5_23b7_4d4c_934c_0bf455cce5ba
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q9H3S5
name: PIGM
constant: false
is encoded by: hsa:93183
type: Species
has only substance units: false

metaM glu5sa m
name: L-Glutamate 5-semialdehyde
constant: false
is: C01165
initial concentration: 1.0
is: HMDB02104
is: SBO:0000247
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
type: Species
initial amount: NaN
is: CHEBI:17232
boundary condition: false
has only substance units: false

metaM lpchol hs c
is: CHEBI:60479
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: lysophosphatidylcholine
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110012#_metaM_fucgalacgalfuc12gal14acglcgalgluside_hs_g
is: HMDB00304
name: Type IIIH glycolipid
boundary condition: false
is: SBO:0000247
notes: FORMULA: C70H122N3O40FULLRCO CHARGE: 0
initial concentration: 1.0
is: CHEBI:57847
type: Species
has only substance units: false
initial amount: NaN
constant: false

metaM acald c
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00990
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
name: acetaldehyde
is: SBO:0000247
is: CHEBI:15343
type: Species

metaM ksi pre24 g
initial concentration: 1.0
is: CHEBI:58053
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
name: keratan sulfate I biosynthesis, precursor 24
boundary condition: false
is: SBO:0000247
is: HMDB00175
constant: false
is: C00130
initial amount: NaN
type: Species
has only substance units: false

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

metaR PYNP2r
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
is: SBO:0000176
modifier: MODEL1310110012#
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.3
type: Reaction
name: pyrimidine-nucleoside phosphorylase (uracil)
product: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#

metaM caro e
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094
type: Species
name: beta-carotene
initial concentration: 1.0
is: CHEBI:17579
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00561
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_70ea84c9_60fa_4c1f_83e8_effe2a64cb39
constant: false
name: _BG035985_1_c
initial amount: NaN
is encoded by: hsa:BG035985
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM uacgam g
constant: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00290
initial concentration: 1.0
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: CHEBI:57705
type: Species

metaM dhea r
is: HMDB00077
initial amount: NaN
has only substance units: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
name: 3beta-hydroxyandrost-5-en-17-one
is: CHEBI:28689
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
constant: false

metaR ME2m
product: MODEL1310110012#
name: malic enzyme (NADP), mitochondrial
reversible: false
fast: false
is: SBO:0000176
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.1.1.40
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.1.1.38
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_20b2eea4_6a2a_48fb_98f7_e55586f97b64
type: Species
is encoded by: hsa:6120
initial concentration: NaN
is: SBO:0000252
name: RPE
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: Q96AT9

metaR APOC LYS BTNP
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110012#
is described by: ECO:0000000
product: MODEL1310110012#
reversible: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110012#
name: proteolysis of apoC-Lys-btn
fast: false

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaR MMMm
reversible: true
fast: false
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/5.4.99.2
name: methylmalonyl-CoA mutase
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
type: Reaction
product: MODEL1310110012#
is: SBO:0000176

metaR C60CPT1
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexanoylcarnitine
type: Reaction

metaR GALASE14ly
modifier: MODEL1310110012#
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
reactant: MODEL1310110012#
is described by: ECO:0000000

metaR EX CE2916 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: neocasomorphin exchange
type: Reaction

metaR RE0344C
fast: false
reversible: true
kinetic law: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110012#
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.2
name: RE0344

http://identifiers.org/biomodels.db/MODEL1310110012#_02389625_26d8_470e_a6e5_f5398857ba9e
is: P09960
name: LTA4H
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:4048
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false

metaM arachcrn m
name: arachidyl carnitine
is: SBO:0000247
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
initial amount: NaN
has only substance units: false
is: HMDB06460
constant: false
initial concentration: 1.0
type: Species
boundary condition: false

metaR SEBCOACROT
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

metaR TSTSTERONESULT
notes: GENE_ASSOCIATION: (6822.1) or (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.8.2.14
is: SBO:0000176
reactant: MODEL1310110012#
product: MODEL1310110012#
reversible: false
type: Reaction
name: testosterone sulfotransferase
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000269
fast: false

metaR NRPPHRSFt
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
product: MODEL1310110012#
is described by: ECO:0000000
kinetic law: MODEL1310110012#
reversible: false
reactant: MODEL1310110012#
name: norepinephrine sulfate transport (diffusion)

http://identifiers.org/biomodels.db/MODEL1310110012#_13e3243b_cccb_4ef0_88f4_d13e03540c62
initial concentration: NaN
constant: false
is: O00154
boundary condition: true
type: Species
name: ACOT7
is: SBO:0000252
has only substance units: false
is encoded by: hsa:11332
initial amount: NaN

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaM 3odcoa m
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB03939
boundary condition: false
initial amount: NaN
is: CHEBI:28528
name: 3-Oxodecanoyl-CoA
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265

metaM cdp n
has only substance units: false
is: CHEBI:58069
type: Species
initial amount: NaN
is: HMDB01546
name: CDP(3-)
constant: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_f263b5ca_2ee4_4c4b_b2e0_b8ff37dfe96b
is encoded by: hsa:100
initial concentration: NaN
name: ADA
has only substance units: false
is: P00813
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_1bbe8e93_391b_4a63_bc05_03d4845510dd
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q96L53
has only substance units: false
name: ST3GAL3
is encoded by: hsa:6487
constant: false
initial amount: NaN

metaR H2Otm
fast: false
is described by: ECO:0000269
reactant: MODEL1310110012#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
kinetic law: MODEL1310110012#
name: H2O transport, mitochondrial
modifier: MODEL1310110012#
product: MODEL1310110012#
type: Reaction

metaM c10dc c
is: HMDB00651
type: Species
initial amount: NaN
name: sebacoyl carnitine
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C17H30NO6 CHARGE: -1
has only substance units: false
is: SBO:0000247

metaM acald e
constant: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial amount: NaN
has only substance units: false
is: HMDB00990
initial concentration: 1.0
type: Species
boundary condition: false
name: acetaldehyde
is: CHEBI:15343
is: SBO:0000247

metaM dadp c
is: CHEBI:57667
name: dADP
boundary condition: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
type: Species
initial concentration: 1.0
is: HMDB01508
is: SBO:0000247
constant: false
has only substance units: false
is: C00206
initial amount: NaN

metaR DM dgpi prot hs r
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dgpi prot hs(r)
type: Reaction

metaM docohepcoa m
boundary condition: false
is: SBO:0000247
constant: false
name: 2,4,7,10,13,16,19-docosaheptenoylcoa
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_1abb142a_b098_4ea8_91f5_605d565ac783
has only substance units: false
is: O14975
constant: false
is: SBO:0000252
is encoded by: hsa:11001
name: SLC27A2
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR OCTDECCACT
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_5dd688d4_be05_4beb_a7a0_f96e792c7f95
initial concentration: NaN
has only substance units: false
is: SBO:0000297
constant: false
has part: B7Z3U6
has part: P54709
initial amount: NaN
is encoded by: hsa:476
boundary condition: true
is encoded by: hsa:483
name: ATP1A1:ATP1B3
type: Species

metaR UAGALDP
kinetic law: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
reversible: false
name: UDP-N-acetylgalactosamine diphosphorylase
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000176

metaM odecoa m
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
is: HMDB01322
initial amount: NaN
type: Species
is: CHEBI:57387
name: Octadecenoyl-CoA (n-C18:1CoA)

http://identifiers.org/biomodels.db/MODEL1310110012#_45ef2e77_3579_4680_8e4d_7f69cfca744f
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4702
name: NDUFA8
is: B1AM93
boundary condition: true

metaM cdp m
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
constant: false
has only substance units: false
is: CHEBI:58069
is: SBO:0000247
is: HMDB01546
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: CDP(3-)

metaR r2018
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false

metaR EX 4mptnl LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-methylpentanal Exchange
type: Reaction

metaM vacc c
is: C08367
is: CHEBI:30828
boundary condition: false
type: Species
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
constant: false
name: trans-vaccenate
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_bc9e5c01_e631_4655_968e_17f06294b03d
has part: P22392
name: NME1:NME2
boundary condition: true
is encoded by: hsa:4830
has only substance units: false
constant: false
is encoded by: hsa:4831
has part: P15531
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000297

metaR ADPACTD
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport into cytosol (diffusion)
type: Reaction

metaM appnn c
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:28261
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C10H16 CHARGE: 0 INCHI: InChI=1S/C10H16/c1-7-4-5-8-6-9(7)10(8,2)3/h4,8-9H,5-6H2,1-3H3/t8-,9-/m1/s1
name: (+)-alpha-pinene
is: HMDB06525

http://identifiers.org/biomodels.db/MODEL1310110012#_620ed3c6_f1a6_4eea_8a45_4ef80a3a6114
is: SBO:0000252
name: EHHADH
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1962
initial amount: NaN
has only substance units: false
type: Species
is: Q9NY65
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_4a18b66c_4f5e_4bb2_99b6_d527cf29299d
is encoded by: hsa:AF080579
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
name: _AF080579_1_c

metaR H2Otn
product: MODEL1310110012#
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110012#
is: SBO:0000185
type: Reaction
name: H2O transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110012#

metaR G16MT U
reversible: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
name: Glycolipid 1,6-alpha-D-mannosyltransferase (uterus)
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_2e68f4dc_c48c_4d24_a51e_7bf8430c6c1c
name: GBA
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: B7Z6S1
is encoded by: hsa:2629
type: Species
is: SBO:0000252

metaR SPHK21c
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
modifier: MODEL1310110012#
fast: false
reversible: false
name: sphingosine kinase 2
kinetic law: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.91
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110012#
reactant: MODEL1310110012#

metaR PHYCBOXL
product: MODEL1310110012#
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
name: L-Phenylalanine carboxy-lyase
reactant: MODEL1310110012#
is described by: ECO:0000212
reversible: false
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.28
type: Reaction
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB

metaR FAOXC164C163x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)x
type: Reaction

metaR ACCOAC
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaM 3aib m
has only substance units: false
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:33094
is: HMDB02166
name: (S)-3-aminoisobutyric acid

metaM g3pc c
initial amount: NaN
is: CHEBI:16870
name: sn-Glycero-3-phosphocholine
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB00086
type: Species
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670

metaM leu L m
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00687
name: L-leucine
is: CHEBI:15603
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
boundary condition: false
type: Species

metaR ECOAH1m
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/4.2.1.18
reversible: true
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
is: SBO:0000176
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
modifier: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110012#

metaM glyclt x
type: Species
is: HMDB00115
has only substance units: false
constant: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
is: CHEBI:29805
boundary condition: false
is: SBO:0000247
name: glycolate
initial concentration: 1.0
initial amount: NaN

metaM appnn e
boundary condition: false
notes: FORMULA: C10H16 CHARGE: 0 INCHI: InChI=1S/C10H16/c1-7-4-5-8-6-9(7)10(8,2)3/h4,8-9H,5-6H2,1-3H3/t8-,9-/m1/s1
initial concentration: 1.0
type: Species
name: (+)-alpha-pinene
initial amount: NaN
is: HMDB06525
is: SBO:0000247
is: CHEBI:28261
constant: false
has only substance units: false

metaM oxa c
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: CHEBI:30623
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB02329
initial concentration: 1.0
has only substance units: false
name: oxalate(2-)
boundary condition: false

metaR CSNATr
is described by: ECO:0000000
reactant: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
fast: false
reversible: true
product: MODEL1310110012#
name: carnitine O-acetyltransferase
kinetic law: MODEL1310110012#
is: SBO:0000176

metaR FBA
reversible: true
type: Reaction
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/4.1.2.13
is: SBO:0000176
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
is described by: ECO:0000134
kinetic law: MODEL1310110012#
product: MODEL1310110012#
name: fructose-bisphosphate aldolase
modifier: MODEL1310110012#
fast: false

metaR NH4tn
reversible: true
name: ammonia nuclear transport
is: SBO:0000185
fast: false
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
type: Reaction
reactant: MODEL1310110012#

metaR FAOXC80
name: Beta oxidation of med/long chain fatty acid
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
product: MODEL1310110012#
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110012#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110012#
reversible: false

metaM ala B c
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00056
name: beta-alanine
has only substance units: false
is: CHEBI:16958
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100

metaM CE5126 x
is: CHEBI:15748
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5126
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
name: (2R)-pristanoyl-CoA
constant: false
is: HMDB00127
is: SBO:0000247

metaM glyleu e
notes: FORMULA: C8H16N2O3 CHARGE: 0
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/102468
initial amount: NaN
is: HMDB00759
has only substance units: false
boundary condition: false
is: C02155
constant: false
is: SBO:0000247
name: Glycylleucine

http://identifiers.org/biomodels.db/MODEL1310110012#_badd66d9_dbf6_418c_ab8f_82349bdbdaba
has only substance units: false
is: P28845
initial concentration: NaN
name: HSD11B1
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:3290
constant: false
is: SBO:0000252

metaR DGCHOLtx
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport

metaR PRPNCOAHYDm
modifier: MODEL1310110012#
name: Propenoyl-CoA hydrolase (m)
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
product: MODEL1310110012#
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110012#
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.18
kinetic law: MODEL1310110012#
is described by: ECO:0000134

metaM hdcecrn c
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
is: SBO:0000247
boundary condition: false
has only substance units: false
name: Hexadecenoyl carnitine
initial concentration: 1.0
constant: false
is: HMDB00222
initial amount: NaN
type: Species

metaR r1609
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110012#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
is described by: ECO:0000000

metaM uacgam c
initial amount: NaN
has only substance units: false
is: CHEBI:57705
initial concentration: 1.0
is: HMDB00290
type: Species
constant: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: SBO:0000247
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
boundary condition: false

metaM hom L c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial concentration: 1.0
type: Species
is: CHEBI:15699
name: L-homoserine
is: HMDB00719
has only substance units: false
constant: false
initial amount: NaN

metaM 3aib c
is: CHEBI:33094
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
name: (S)-3-aminoisobutyric acid
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: HMDB02166
initial concentration: 1.0
constant: false

metaM dolp U r
constant: false
name: dolichyl phosphate(2-)
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
has only substance units: false
boundary condition: false
is: CHEBI:57683

http://identifiers.org/biomodels.db/MODEL1310110012#_3cfe195a_192e_4b5c_90b1_e2e86a7e53fe
name: MECR
type: Species
is encoded by: hsa:51102
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q9BV79

metaM 3hbcoa R c
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
name: (R)-3-hydroxybutanoyl-CoA(4-)
constant: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14-,18-,19-,20+,24-/m1/s1
is: HMDB01166
initial concentration: 1.0

metaM dcsptn1 c
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
name: docosa-4,7,10,13,16-pentaenoic acid
has only substance units: false
is: http://identifiers.org/pubchem.compound/5282848
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB13123
type: Species
is: SBO:0000247

metaM leu L c
name: L-leucine
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:15603
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00687
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_6455656f_0a20_4dab_89ad_1b79d1eeba18
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
name: ST3GAL3
initial concentration: NaN
is encoded by: hsa:6487
type: Species
has only substance units: false

metaR H2Otly
type: Reaction
fast: false
product: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: H2O transport, lysosomal
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#

metaR SO4CLtex2
name: sulfate transport via chloride countertransport (2:1)
type: Reaction
reversible: false
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000304
reactant: MODEL1310110012#

metaM spmd e
is: CHEBI:57834
is: HMDB01257
name: Spermidine
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
constant: false
is: C00315
boundary condition: false
has only substance units: false

metaR O16G1e
fast: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reversible: false
type: Reaction
is described by: ECO:0000000
name: oligo-1,6-glucosidase (glygn4 -> glygn5), extracellular
reactant: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.10

metaR r1608
reactant: MODEL1310110012#
reversible: true
fast: false
kinetic law: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110012#
type: Reaction

metaR HSPGtly
reactant: MODEL1310110012#
product: MODEL1310110012#
fast: false
reversible: false
kinetic law: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: heparan sulfate transport, extracellular to lysosome
is: SBO:0000185
type: Reaction

metaM tethex3 e
constant: false
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: tetracosahexaenoic acid, n-3
is: HMDB02007
type: Species

metaM dctp n
is: HMDB00998
is: SBO:0000247
type: Species
name: dCTP
constant: false
is: CHEBI:16311
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
boundary condition: false
is: C00458
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR PRFGS
name: phosphoribosylformylglycinamidine synthase
is described by: ECO:0000269
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/6.3.5.3
modifier: MODEL1310110012#
reactant: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
fast: false
kinetic law: MODEL1310110012#

metaR CSNATp
fast: false
is: SBO:0000176
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
reactant: MODEL1310110012#
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
modifier: MODEL1310110012#
reversible: true
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.7

metaM ala B e
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB00056
name: beta-alanine
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
boundary condition: false
constant: false
is: CHEBI:16958
is: SBO:0000247

metaM glyleu c
notes: FORMULA: C8H16N2O3 CHARGE: 0
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/102468
initial amount: NaN
boundary condition: false
is: HMDB00759
is: C02155
name: Glycylleucine

http://identifiers.org/biomodels.db/MODEL1310110012#_metaM_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_c
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00143
boundary condition: false
is: CHEBI:12936
initial concentration: 1.0
constant: false
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
is: SBO:0000247
notes: FORMULA: C96H165N4O60FULLRCO CHARGE: 0

metaR VACCCPT1
reversible: false
product: MODEL1310110012#
is described by: ECO:0000000
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
reactant: MODEL1310110012#
type: Reaction
name: carnitine O-palmitoyltransferase
fast: false
modifier: MODEL1310110012#

metaR NH4tp
name: ammonia peroxisomal transport
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110012#
fast: false
product: MODEL1310110012#
is: SBO:0000185

metaM lgnccoa c
name: lignocericyl coenzyme A
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
is: HMDB06526
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_fbebec2a_1757_4f0b_a542_188a4d204db6
is encoded by: hsa:160728
type: Species
initial concentration: NaN
is: Q8N695
is: SBO:0000252
constant: false
name: SLC5A8
boundary condition: true
has only substance units: false
initial amount: NaN

metaM h2o x
is: C00001
initial amount: NaN
is: SBO:0000247
is: CHEBI:15377
boundary condition: false
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
initial concentration: 1.0
name: H2O
constant: false
has only substance units: false

metaR ACHtn
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110012#
reversible: true
name: Acetylcholin transport, nuclear trhough pores
fast: false
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
is described by: ECO:0000000
product: MODEL1310110012#

metaR ATPH1e
notes: GENE_ASSOCIATION: (954.1) or (954.2) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: false
product: MODEL1310110012#
name: ATP diphosphohydrolase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.6
fast: false
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000176
type: Reaction

metaR r1607
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
product: MODEL1310110012#
fast: false
reactant: MODEL1310110012#

metaR RE3218C
is: SBO:0000176
name: RE3218
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
type: Reaction
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.1.6.2
reversible: true
kinetic law: MODEL1310110012#
fast: false
product: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000000

metaR C120CPT1
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanoylcarnitine
type: Reaction

metaR LNLCCPT1
name: carnitine O-palmitoyltransferase
product: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
is described by: ECO:0000269

metaR FAOXC14C14OHm
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C14OH)m
type: Reaction

metaM hom L e
boundary condition: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial concentration: 1.0
type: Species
is: CHEBI:15699
is: HMDB00719
constant: false
name: L-homoserine
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR DNDPt28m
reversible: false
is: SBO:0000185
modifier: MODEL1310110012#
name: dCDP transport via dGDP antiport
is described by: ECO:0000269
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
type: Reaction

metaR r1606
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaM spmd c
is: CHEBI:57834
name: Spermidine
initial concentration: 1.0
is: HMDB01257
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
constant: false
is: C00315
has only substance units: false

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_c7bffbaa_cb8e_4ce6_8c15_9a76fe8e5310
initial amount: NaN
has only substance units: false
boundary condition: true
name: FUT8
initial concentration: NaN
constant: false
is: B4DFS7
type: Species
is encoded by: hsa:2530
is: SBO:0000252

metaM tethex3 c
type: Species
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
has only substance units: false
is: HMDB02007
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: tetracosahexaenoic acid, n-3

http://identifiers.org/biomodels.db/MODEL1310110012#_e0aba78e_05e9_4351_a9e9_9d4bb7f1e20c
initial concentration: NaN
is encoded by: hsa:4719
name: NDUFS1
has only substance units: false
constant: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P28331

http://identifiers.org/biomodels.db/MODEL1310110012#_b1cd8140_6ba7_4b72_a08e_b706a19fe308
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
name: _BE966236_1_m
has only substance units: false
initial amount: NaN
is encoded by: hsa:BE966236
boundary condition: true

metaR ACGALK2
fast: false
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
name: N-acetylgalactosamine kinase (ITP)
type: Reaction
product: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110012#_2dc0b805_edf5_4c71_8c07_2c799f091c3d
is: SBO:0000252
is encoded by: hsa:4952
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
constant: false
name: OCRL

metaR DURIPP
reversible: true
is described by: ECO:0000269
fast: false
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
name: deoxyuridine phosphorylase
is version of: http://identifiers.org/ec-code/2.4.2.3
product: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_4e71bdac_c3a5_40aa_b762_972e3f05c4fd
has only substance units: false
name: SCP2
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6342
is: C9JC79

metaR LNLCCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110012#
is described by: ECO:0000000
reactant: MODEL1310110012#
is: SBO:0000176
name: carnitine transferase
product: MODEL1310110012#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110012#
type: Reaction

metaM 4mop m
boundary condition: false
is: HMDB00695
name: 4-methyl-2-oxopentanoate
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
is: CHEBI:17865
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
constant: false

metaM odecoa c
constant: false
initial amount: NaN
boundary condition: false
name: Octadecenoyl-CoA (n-C18:1CoA)
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: CHEBI:3793
type: Species
is: SBO:0000247
is: HMDB01322

metaM CE2420 m
initial amount: NaN
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
is: CHEBI:28387
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB11123
constant: false
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA

metaR ARACHCPT1
kinetic law: MODEL1310110012#
product: MODEL1310110012#
modifier: MODEL1310110012#
reversible: false
type: Reaction
name: carnitine transferase
reactant: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110012#_d2518a94_5ea4_43fc_aae4_55c35a9d90ac
constant: false
is: Q13057
is encoded by: hsa:80347
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
name: COASY
initial amount: NaN

metaM prostge2 c
is: HMDB01220
initial concentration: 1.0
has only substance units: false
name: prostaglandin E2(1-)
is: CHEBI:606564
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
constant: false

metaR FAOXC122C101m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

metaR FACOAL2251
reversible: true
is: SBO:0000176
fast: false
modifier: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
name: fatty-acid--CoA ligase
product: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaR FAOXC204C205x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C20:5)x
type: Reaction

metaR r0226
kinetic law: MODEL1310110012#
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
is: SBO:0000176
product: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
fast: false
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_metaM_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_e
constant: false
initial concentration: 1.0
notes: FORMULA: C96H165N4O60FULLRCO CHARGE: 0
is: CHEBI:0
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00143
is: C00124
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
has only substance units: false
initial amount: NaN

metaR r1605
product: MODEL1310110012#
is described by: ECO:0000000
reactant: MODEL1310110012#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110012#

metaR FAOXC181C181OHm
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C18:1OH)m
type: Reaction

metaR H2O2tn
reversible: true
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110012#
is described by: ECO:0000000
name: hydrogen peroxide nuclear transport
kinetic law: MODEL1310110012#

metaM caro c
initial concentration: 1.0
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094
is: HMDB00561
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
name: beta-carotene
is: CHEBI:17579
is: SBO:0000247
type: Species

metaR 3HCO3 NAt
name: 3HCO3_NAt
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
product: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
is described by: ECO:0000134
reactant: MODEL1310110012#
is: SBO:0000185

metaM ptdcacrn c
name: pendtadenoyl carnitine
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:18303

metaR PROD2
is version of: http://identifiers.org/ec-code/1.5.99.8
product: MODEL1310110012#
reactant: MODEL1310110012#
reversible: false
modifier: MODEL1310110012#
fast: false
is described by: ECO:0000254
is: SBO:0000176
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR
type: Reaction
name: Proline dehydrogenase

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaR A4GNT2g
product: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
name: alpha 1,4-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (51146.1) SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10430883 NOTES:EC 2.4.1.- NCD
reversible: false
fast: false

metaR ARACHCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110012#
reversible: false
modifier: MODEL1310110012#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
is: SBO:0000176
name: carnitine transferase
kinetic law: MODEL1310110012#
product: MODEL1310110012#

metaM pcrn x
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/107738
is: HMDB00824
name: propionyl-carnitine
constant: false
initial concentration: 1.0
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3

metaR ABTti
reversible: false
product: MODEL1310110012#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
name: L-arabinitol transport via passive diffusion
kinetic law: MODEL1310110012#
is: SBO:0000185
reactant: MODEL1310110012#

metaR NACHEX9ly
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
fast: false
modifier: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110012#
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110012#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110012#

metaR IMPC
name: IMP cyclohydrolase
type: Reaction
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
is version of: http://identifiers.org/ec-code/2.1.2.3
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110012#
is: SBO:0000176
fast: false
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_a7a0b0c9_3cec_452b_851e_1fff8de239ff
is: SBO:0000297
has only substance units: false
is encoded by: hsa:4830
constant: false
name: NME1:NME2
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN

metaR r1604
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110012#
reversible: true
reactant: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110012#

metaM strch1 e
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:456215
constant: false
is: C00020
notes: FORMULA: C66H112O56 CHARGE: 0
is: HMDB00045
type: Species
name: starch, structure 1 (1,6-{7[1,4-Glc], 4[1,4-Glc]})
has only substance units: false
initial amount: NaN

metaR FAOXC101m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

metaR BALABETAtc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of beta alanine into the intestinal cells by beta transport system
type: Reaction

metaM r1p c
name: alpha-D-Ribose 1-phosphate
initial concentration: 1.0
is: CHEBI:57720
boundary condition: false
type: Species
is: C00442
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
is: SBO:0000247
is: HMDB01489
initial amount: NaN
has only substance units: false
constant: false

metaR PSt3
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
reversible: true
fast: false
reactant: MODEL1310110012#
name: phosphatidylserine transport
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269

metaR r1796
reversible: false
type: Reaction
kinetic law: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
modifier: MODEL1310110012#
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_d6a038d0_1233_473f_a9d7_5423886650af
is encoded by: hsa:509
constant: false
name: ATP5C1
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: Q6I9V2
is: SBO:0000252
initial amount: NaN

metaR MALTe
reversible: false
name: alpha-glucosidase, extracellular
is version of: http://identifiers.org/ec-code/3.2.1.20
modifier: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8972.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:3143729 NOTES:IF
reactant: MODEL1310110012#
is described by: ECO:0000269
kinetic law: MODEL1310110012#
fast: false

metaM prostge2 e
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB01220
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: CHEBI:606564
type: Species
has only substance units: false
is: SBO:0000247
name: prostaglandin E2(1-)

http://identifiers.org/biomodels.db/MODEL1310110012#_6155056e_a78b_428b_90df_72d3ba8bdc1d
is: Q9P1E4
constant: false
name: MAN2A2
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:4122
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR r1603
product: MODEL1310110012#
is described by: ECO:0000000
reactant: MODEL1310110012#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110012#
reversible: true
is: SBO:0000185

metaM cdp e
is: SBO:0000247
type: Species
name: CDP(3-)
is: HMDB01546
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: CHEBI:58069
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_a4dc8408_d35f_4115_a631_37bfe4614527
boundary condition: true
is encoded by: hsa:26289
constant: false
is: SBO:0000252
name: AK5
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_metaM_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_g
is: CHEBI:61648
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C96H165N4O60FULLRCO CHARGE: 0
type: Species
boundary condition: false
initial amount: NaN
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
constant: false
has only substance units: false

metaM apoC Lys btn c
boundary condition: false
is: HMDB00182
notes: FORMULA: C16H27N4O3SX CHARGE: 0
initial amount: NaN
type: Species
is: CHEBI:32551
constant: false
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM dcsptn1 e
name: docosa-4,7,10,13,16-pentaenoic acid
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/5282848
type: Species
initial amount: NaN
is: HMDB13123
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaM leu L e
is: HMDB00687
type: Species
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15603
name: L-leucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_acfa593c_da68_41a1_9c0a_31bfd2566108
has only substance units: false
type: Species
constant: false
boundary condition: true
initial amount: NaN
name: SULT1A1
is: SBO:0000252
is: P50225
is encoded by: hsa:6817
initial concentration: NaN

metaM air c
initial amount: NaN
is: C03373
is: HMDB01235
type: Species
constant: false
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
has only substance units: false
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:58592

metaR RE2759X
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (23600.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:11060344,PMID:11060359 NOTES:
name: RE2759
is described by: ECO:0000000
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/5.1.99.4
is: SBO:0000176

metaM 3aib e
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:33094
is: SBO:0000247
has only substance units: false
is: HMDB02166
name: (S)-3-aminoisobutyric acid
boundary condition: false
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284

http://identifiers.org/biomodels.db/MODEL1310110012#_58f2fcf2_f59a_4d8f_83b8_e4f10c05fa77
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:5277
name: PIGA
is: B3KUV7
boundary condition: true
initial concentration: NaN

metaM lnlncgcoa m
boundary condition: false
is: HMDB06368
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: CHEBI:57363
name: gamma-linolenoyl-CoA(4-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_c1c6d267_a1c0_4663_8b7e_cfcf021de47f
is: SBO:0000252
is encoded by: hsa:4882
constant: false
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
name: NPR2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_f5ef40e8_7fff_4e66_b941_ee7a3ed353b1
has only substance units: false
constant: false
is: B4DY56
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: ATP5A1
initial amount: NaN
is encoded by: hsa:498
type: Species

metaM pmtcrn c
boundary condition: false
initial amount: NaN
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:17490
name: L-palmitoylcarnitine
is: SBO:0000247
is: HMDB00222
type: Species

metaM nh4 x
initial amount: NaN
boundary condition: false
name: Ammonium
has only substance units: false
is: C01342
initial concentration: 1.0
is: CHEBI:28938
is: HMDB00051
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaR r1602
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM ksi deg12 l
name: keratan sulfate I, degradation product 12
has only substance units: false
boundary condition: false
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
initial concentration: 1.0
is: CHEBI:12936
constant: false
is: SBO:0000247
is: HMDB00143
type: Species
initial amount: NaN

metaM na1 e
is: CHEBI:4541
initial amount: NaN
is: HMDB00588
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: Na CHARGE: 1
is: C01330
constant: false
name: Sodium
boundary condition: false

metaR CYSGLYexR
is described by: ECO:0000000
name: L-cysteine/glycine reversible exchanger
is: SBO:0000185
modifier: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
kinetic law: MODEL1310110012#
product: MODEL1310110012#

metaR PROD2m
is described by: ECO:0000254
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.99.8
product: MODEL1310110012#
kinetic law: MODEL1310110012#
name: Proline dehydrogenase (m)
reactant: MODEL1310110012#
reversible: false
type: Reaction
modifier: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m

metaM pmtcrn r
is: HMDB00222
is: SBO:0000247
constant: false
has only substance units: false
name: L-palmitoylcarnitine
boundary condition: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
initial amount: NaN
is: CHEBI:17490
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_2b2cd738_5782_4960_af97_eaac1c327fab
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: _AI378339_1_m
type: Species
is encoded by: hsa:AI378339
initial amount: NaN
boundary condition: true

metaM lnlncgcoa c
is: CHEBI:57363
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB06368
initial amount: NaN
name: gamma-linolenoyl-CoA(4-)
is: SBO:0000247
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
type: Species

metaR URIt
product: MODEL1310110012#
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110012#
type: Reaction
name: uridine facilated transport in cytosol
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT

metaR NDP3ex
kinetic law: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
fast: false
reversible: false
is described by: ECO:0000269
name: nucleoside-diphosphatase (GDP), extracellular
is: SBO:0000176
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.6.1.6
modifier: MODEL1310110012#

metaM 5HPET r
initial amount: NaN
constant: false
is: HMDB01193
is: CHEBI:57450
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: 5(S)-HPETE(1-)

http://identifiers.org/biomodels.db/MODEL1310110012#_cc8e2981_7f79_474e_8657_c6c9ecaba40b
type: Species
is: Q5TDP6
constant: false
is: SBO:0000252
boundary condition: true
name: LGSN
initial concentration: NaN
is encoded by: hsa:51557
has only substance units: false
initial amount: NaN

metaM leuktrF4 c
is: HMDB06465
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:27491
constant: false
name: leukotriene F4

metaR S4TASE4ly
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110012#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
product: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.12
kinetic law: MODEL1310110012#
fast: false
reversible: true

metaR PIter
is: SBO:0000185
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
kinetic law: MODEL1310110012#
name: phosphate transport, endoplasmic reticulum
is described by: ECO:0000212

http://identifiers.org/biomodels.db/MODEL1310110012#_ec812a76_5381_435a_956c_939a728105c0
name: PANK4
is: Q9NVE7
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:55229

http://identifiers.org/biomodels.db/MODEL1310110012#_a58a3789_120a_49de_bc40_efc9f4be3988
initial amount: NaN
name: PDE9A
constant: false
has only substance units: false
is encoded by: hsa:5152
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_54da9aa1_0ac0_48b3_b858_81e8cdd93c04
has only substance units: false
is encoded by: hsa:8613
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: O14495
name: PPAP2B

metaR CYTDK2m
type: Reaction
fast: false
reversible: false
product: MODEL1310110012#
kinetic law: MODEL1310110012#
name: cytidine kinase (ATP), mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reactant: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000000

metaM h2o r
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
initial amount: NaN
name: H2O
type: Species
is: C00001
is: CHEBI:15377
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false

metaM 2docohexecoa m
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
name: 2,7,10,13,16,19-docosahexenoylcoa
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000247

metaM xol7ah3 c
is: SBO:0000247
initial amount: NaN
is: CHEBI:28540
name: 5beta-cholestane-3alpha,7alpha,26-triol
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: HMDB12455
has only substance units: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444

http://identifiers.org/biomodels.db/MODEL1310110012#_350254f0_1e68_4109_97c1_3f5c0e5b0dfa
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4830
type: Species
is: SBO:0000252
is: P15531
name: NME1
initial amount: NaN
has only substance units: false

metaR NDPK5n
modifier: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
is: SBO:0000176
product: MODEL1310110012#
is described by: ECO:0000304
reactant: MODEL1310110012#
fast: false

metaR GBAl
type: Reaction
product: MODEL1310110012#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110012#
name: Glucosylceramidase
is: SBO:0000176
reversible: false
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (2629.4) or (2629.1) or (2629.3) or (2629.2) or (2629.5) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 4 AUTHORS: PMID:11933202,PMID:12667141 NOTES:NJ
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.45

metaM mal L c
has only substance units: false
name: (S)-malate(2-)
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
type: Species
is: CHEBI:15589
is: HMDB00156
constant: false
initial concentration: 1.0

metaR r1799
type: Reaction
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000185
name: Y+LAT2 Utilized transport
fast: false
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
product: MODEL1310110012#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110012#_7719a212_9d2d_425f_8499_6d94565d736f
is encoded by: hsa:4247
is: Q10469
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
name: MGAT2
has only substance units: false
type: Species
is: SBO:0000252

metaM aprgstrn c
constant: false
initial concentration: 1.0
name: (20S)-20-hydroxypregn-4-en-3-one
is: SBO:0000247
initial amount: NaN
is: HMDB03069
has only substance units: false
is: CHEBI:28453
type: Species
boundary condition: false
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042

metaR CYSGLTH
type: Reaction
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
name: Glutathione:cystine oxidoreductase
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
is: SBO:0000176
reversible: true
fast: false
product: MODEL1310110012#
is described by: ECO:0000000

metaR FAOXC140
reversible: false
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
type: Reaction
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR FACOAL2252
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000269
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110012#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110012#
reversible: true

metaM 3ivcrn e
is: SBO:0000247
name: 3-hydroxy-isovaleryl carnitine
notes: FORMULA: C12H23NO5 CHARGE: 0
constant: false
initial amount: NaN
is: HMDB13336
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false

metaR FAOXC13C11m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C13-->C11)m
type: Reaction

metaR ACACT5p
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000269
reversible: false
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
fast: false
reactant: MODEL1310110012#
modifier: MODEL1310110012#

metaM decdicrn c
constant: false
name: decadienoyl carnitine
initial concentration: 1.0
notes: FORMULA: C17H29NO4 CHARGE: 0
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB13325

http://identifiers.org/biomodels.db/MODEL1310110012#_6d5129af_faea_47e7_bbc8_f1511ec178f5
is: P07686
is encoded by: hsa:3074
initial amount: NaN
has only substance units: false
name: HEXB
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial concentration: NaN

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_0d8a777e_28f2_49fe_9ce3_08e7f3a6fc17
is: O60909
initial amount: NaN
is encoded by: hsa:8704
constant: false
has only substance units: false
is: SBO:0000252
name: B4GALT2
initial concentration: NaN
type: Species
boundary condition: true

metaM na1 r
is: SBO:0000247
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
boundary condition: false
is: HMDB00588
name: sodium(1+)
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: CHEBI:29101

http://identifiers.org/biomodels.db/MODEL1310110012#_b7a38ed5_63bc_43ea_896b_c7873f96c24e
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
name: ABAT
is encoded by: hsa:18
boundary condition: true

metaR r0224
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_400e6406_1fb9_4cbb_8a09_49bd2ba44fac
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6916
is: Q53F23
initial amount: NaN
type: Species
name: TBXAS1

metaR LYSOXp
is described by: ECO:0000000
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
product: MODEL1310110012#
name: L-lysine oxidase, peroxisomal
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_4daff2d8_3296_49f6_aa72_335da0599373
is: SBO:0000252
is: Q14032
initial concentration: NaN
has only substance units: false
is encoded by: hsa:570
boundary condition: true
name: BAAT
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_3ed42bc6_8e64_428f_b375_502eac76b971
name: ACSL5
is encoded by: hsa:51703
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is: Q9ULC5
has only substance units: false

metaR GLCt2 2
product: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110012#
name: D-glucose transport in via proton symport
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110012#

metaR G5SDym
reactant: MODEL1310110012#
type: Reaction
name: glutamate-5-semialdehyde dehydrogenase (m)
product: MODEL1310110012#
fast: false
is described by: ECO:0000254
is: SBO:0000176
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.2.1.41
modifier: MODEL1310110012#
reversible: false
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 1.2.1.41 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m TDV: name change from G5SDm

http://identifiers.org/biomodels.db/MODEL1310110012#_c098de59_6adb_45d1_8fd2_0c48d4d5e7c7
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q11201
type: Species
initial concentration: NaN
is encoded by: hsa:6482
name: ST3GAL1
constant: false
boundary condition: true

metaM leuktrF4 e
is: HMDB06465
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:27491
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
constant: false
boundary condition: false
has only substance units: false
name: leukotriene F4

metaR RE0944E
is described by: ECO:0000000
kinetic law: MODEL1310110012#
name: RE0944
product: MODEL1310110012#
is: SBO:0000176
reversible: true
fast: false
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1

metaM ala B m
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
name: beta-alanine
initial amount: NaN
is: CHEBI:16958
is: HMDB00056
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_61303cea_c483_4b89_8743_12e175b8f4b2
constant: false
is encoded by: hsa:314
initial amount: NaN
name: AOC2
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true

metaR NACASPtm
name: N-acetyl-L-aspartate transport (mitochondria to cytosol)
reversible: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11279290 NOTES:MM
type: Reaction
fast: false
reactant: MODEL1310110012#

metaM mal L e
name: (S)-malate(2-)
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
is: HMDB00156
is: CHEBI:15589
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0

metaR FACOAL170
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
reversible: true
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
is: SBO:0000176
is described by: ECO:0000000
name: fatty-acid--CoA ligase
reactant: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3

metaM pmtcrn m
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
constant: false
initial concentration: 1.0
has only substance units: false
name: L-palmitoylcarnitine
boundary condition: false
is: CHEBI:17490
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00222

metaM idour e
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
type: Species
is: HMDB02704
name: L-iduronate
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:21338
is: SBO:0000247

metaR r1078
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
name: Vesicular transport
fast: false

metaR L LACt2r
name: L-lactate reversible transport via proton symport
reactant: MODEL1310110012#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
fast: false
reversible: true
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000185
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_24da2b2f_37bb_4a53_acee_54b8d52127be
is: E9PAX2
boundary condition: true
type: Species
has only substance units: false
constant: false
name: G6PC2
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:57818
initial concentration: NaN

metaM decdicrn e
constant: false
boundary condition: false
name: decadienoyl carnitine
type: Species
initial amount: NaN
notes: FORMULA: C17H29NO4 CHARGE: 0
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB13325

http://identifiers.org/biomodels.db/MODEL1310110012#_7d952f5c_9e64_40f4_9a18_fbe398a50902
initial amount: NaN
is encoded by: hsa:8867
is: C9JFZ1
is: SBO:0000252
constant: false
boundary condition: true
name: SYNJ1
has only substance units: false
initial concentration: NaN
type: Species

metaM aprgstrn e
is: HMDB03069
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:28453
initial concentration: 1.0
name: (20S)-20-hydroxypregn-4-en-3-one
is: SBO:0000247
type: Species
has only substance units: false

metaM retinol c
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: SBO:0000247
type: Species
is: CHEBI:50211
initial amount: NaN
is: HMDB00305
constant: false
has only substance units: false
name: retinol
initial concentration: 1.0

metaR RE1573M
modifier: MODEL1310110012#
name: RE1573
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/5.3.3.8
fast: false
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
reactant: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110012#
reversible: true

metaR CSNATm
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
is described by: ECO:0000269
type: Reaction
product: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.7
name: carnitine O-aceyltransferase, mitochondrial
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#

metaM dolmanp U c
is: CHEBI:15809
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: SBO:0000247
initial amount: NaN
name: Dolichyl phosphate D-mannose, human uterine homolog

http://identifiers.org/biomodels.db/MODEL1310110012#_ddeee9cf_3652_41f3_b228_888a70c32f4b
is encoded by: hsa:9162
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: DGKI
is: O75912

metaR GLXO1
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.2.4
is version of: http://identifiers.org/ec-code/1.1.1.27
name: glyoxylate oxidase
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (3939.1) or (55293.1) or (3945.1 and 3939.1) or (197257.1) or (92483.1) or (3945.1) or (160287.1) or (3948.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.3.5 Confidence Level: 4 AUTHORS: PMID:12768081,PMID:9038835,PMID:9604807,PMID:9783918 NOTES:NCD
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
type: Reaction

metaR FAOXC163GC142m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaR UDPDOLPT U
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.4.1.117
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:10359825,PMID:8280060 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110012#
fast: false
product: MODEL1310110012#
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (uterus)

metaR NACHEX27ly
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
reversible: false
product: MODEL1310110012#
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000269
modifier: MODEL1310110012#

metaR GTHRDt
fast: false
product: MODEL1310110012#
reversible: true
reactant: MODEL1310110012#
name: Glutathione transport into mitochondria
is described by: ECO:0000000
kinetic law: MODEL1310110012#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.

metaM alpam m
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
name: S-aminomethyldihydrolipoamide
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
type: Species
is: HMDB06239
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_c76f526f_976f_40e2_8ed3_85bf510fbb7a
type: Species
initial concentration: NaN
is: SBO:0000252
name: CA7
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: Q86YU0
is encoded by: hsa:766

metaR RAI2
reversible: true
reactant: MODEL1310110012#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110012#
product: MODEL1310110012#
name: retinal isomerase (9-cis)
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110012#_b8728961_d9b1_4bac_99e0_c68c15657015
is encoded by: hsa:5161
initial amount: NaN
has only substance units: false
constant: false
is: P29803
name: PDHA2
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN

metaR DURIt
kinetic law: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110012#
name: deoxyuridine transport via diffusion
reversible: true
product: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110012#_da647ecb_8860_4bd7_9215_3d671e32700a
is: SBO:0000252
is: Q5FWF5
is encoded by: hsa:114799
initial amount: NaN
has only substance units: false
type: Species
name: ESCO1
initial concentration: NaN
constant: false
boundary condition: true

metaR r2443
is described by: ECO:0000000
product: MODEL1310110012#
type: Reaction
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
kinetic law: MODEL1310110012#
is: SBO:0000185
reversible: false
reactant: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM c6dc x
type: Species
notes: FORMULA: C13H22NO6 CHARGE: -1
initial concentration: 1.0
is: HMDB04047
initial amount: NaN
is: C14143
has only substance units: false
boundary condition: false
constant: false
name: adipoyl carnitine
is: SBO:0000247

metaM idour c
constant: false
is: CHEBI:21338
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
name: L-iduronate
boundary condition: false
is: HMDB02704
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_bc29c075_5a4c_42d6_8998_86c9fb9815ea
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is: Q9BWD1
is encoded by: hsa:39
name: ACAT2

http://identifiers.org/biomodels.db/MODEL1310110012#_5211d1b6_7f7a_49f0_b5c5_c8effffb8fbb
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110012#_e664662a_1c85_4023_821f_d775273b292d
boundary condition: true
type: Species
name: AGPAT5
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q9NUQ2
initial amount: NaN
constant: false
is encoded by: hsa:55326

metaM lnlccoa r
constant: false
is: http://identifiers.org/pubchem.compound/5462164
is: SBO:0000247
is: HMDB01064
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
name: linoleic coenzyme A
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_01fe03ed_0a46_48af_bc39_585eb36b1288
initial concentration: NaN
has only substance units: false
name: ADCY4
is: Q8NFM4
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:196883
is: SBO:0000252
boundary condition: true

metaR RE3624M
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
type: Reaction
reactant: MODEL1310110012#
reversible: false
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
name: RE3624
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_1e2052a8_ec88_4bab_ba04_6231d59e3324
initial amount: NaN
name: GALNT13
has only substance units: false
is: SBO:0000252
type: Species
is: Q8IUC8
boundary condition: true
is encoded by: hsa:114805
constant: false
initial concentration: NaN

metaR FBP
name: fructose-bisphosphatase
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2203.1) or (8789.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.11 Confidence Level: 0 AUTHORS: PMID:9678974 NOTES:SMP
modifier: MODEL1310110012#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.11
reversible: false
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
product: MODEL1310110012#

metaR PROSTGD2t
kinetic law: MODEL1310110012#
reversible: true
product: MODEL1310110012#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
modifier: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
name: prostaglandin transport via bicarbonate countertransport
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110012#_f55a0b1b_7e02_4e75_b72c_01e28ff949a5
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6584
is: O76082
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
name: SLC22A5
boundary condition: true

metaR C10OHc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdecanoylcarnitinec
type: Reaction

metaR FAOXC123C102m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)m
type: Reaction

metaM HC01409 m
name: Hexanoyl-CoA
type: Species
initial amount: NaN
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:27540
initial concentration: 1.0
boundary condition: false

metaR CHOLD2m
type: Reaction
product: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (55349.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.99.1 Confidence Level: 4 AUTHORS: PMID:15321791 NOTES:
fast: false
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.1.99.1
name: choline dehydrogenase (FAD acceptor), mitochondrial

metaR PYDXDH
is version of: http://identifiers.org/ec-code/1.2.3.1
name: pyridoxal dehydrogenase
fast: false
is described by: ECO:0000269
reactant: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.2.3.1 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:IT
modifier: MODEL1310110012#
reversible: false
kinetic law: MODEL1310110012#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110012#_b18e2633_f9b3_41f5_a197_d21512d9d001
constant: false
is encoded by: hsa:8372
is: O43820
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
name: HYAL3

metaM hs deg15 l
type: Species
has only substance units: false
is: CHEBI:16126
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
is: SBO:0000247
name: heparan sulfate, degradation product 15
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_afed2fd6_b80e_48b3_96f5_5d45921c5eec
name: DGKD
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:8527

metaR RE1135C
is: SBO:0000176
is described by: ECO:0000000
fast: false
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:10049998,PMID:1606923 NOTES:
type: Reaction
reversible: true
name: RE1135
reactant: MODEL1310110012#
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.1.6.2

metaM ppi c
initial concentration: 1.0
is: C00013
is: CHEBI:0
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3
type: Species
has only substance units: false
name: Diphosphate
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00250

http://identifiers.org/biomodels.db/MODEL1310110012#_8d942f73_8099_4c6e_b5a4_6ec5bbb29136
type: Species
name: DPAGT1
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1798
boundary condition: true

metaR AMY1e
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (6520.1) or (280.1) or (278.1) or (276.1) or (277.1) or (6519.1 and 11136.1) or (276.2) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
reversible: false
name: alpha-amylase, extracellular (strch1 -> strch2)
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1
product: MODEL1310110012#
is described by: ECO:0000000
modifier: MODEL1310110012#
reactant: MODEL1310110012#
fast: false

metaM ttdca c
initial concentration: 1.0
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
has only substance units: false
is: SBO:0000247
is: HMDB00806
constant: false
type: Species
name: myristate
is: CHEBI:30807
boundary condition: false
initial amount: NaN

metaM msa m
is: CHEBI:33190
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB11111
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
has only substance units: false
type: Species
constant: false
name: 3-oxopropanoate

metaR PI4P3K
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
is version of: http://identifiers.org/ec-code/2.7.1.154
reversible: false
product: MODEL1310110012#
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000000
name: phosphatidylinositol 4-phosphate 3-kinase
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.153
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110012#
is: SBO:0000176

metaM CE5118 m
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
initial concentration: 1.0
is: CHEBI:57923
constant: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
type: Species
boundary condition: false

metaR DECDICRNe
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of decadienoyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_2f972475_9171_4a40_9d21_2a34c3598473
boundary condition: true
is encoded by: hsa:8693
name: GALNT4
is: Q8N4A0
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_1ffb3825_3f4c_4f57_85a7_f98b83f9a1b4
is: Q86V21
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:65985
constant: false
initial amount: NaN
type: Species
name: AACS
boundary condition: true

metaR r0679
is: SBO:0000176
kinetic law: MODEL1310110012#
type: Reaction
modifier: MODEL1310110012#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reactant: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
reversible: true
product: MODEL1310110012#

metaR r1492
reversible: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110012#
name: Utilized transport

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR DLNLCGCPT1
type: Reaction
name: carnitine O-palmitoyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110012#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110012#
reversible: false
modifier: MODEL1310110012#
is: SBO:0000176
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110012#_9dc7b445_b6ce_41b8_a34e_bbfa17275021
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AA177072
has only substance units: false
name: _AA177072_1_x
initial amount: NaN

metaR CHAT
name: Choline O-acetyltransferase
is: SBO:0000176
fast: false
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.6
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
reactant: MODEL1310110012#
is described by: ECO:0000269
modifier: MODEL1310110012#
reversible: true
type: Reaction

metaR DOPAt4 2 r
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Dopamine reversible transport in via sodium symport (1:2)
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
reversible: true
modifier: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
fast: false

metaR CYSASNNaEx
kinetic law: MODEL1310110012#
reversible: false
product: MODEL1310110012#
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110012#
is: SBO:0000185
modifier: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaM ksi pre32 g
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
boundary condition: false
is: CHEBI:28067
type: Species
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 32
constant: false
has only substance units: false
initial amount: NaN

metaR FUT17g
type: Reaction
name: Galactoside 2-alpha-L-fucosyltransferase 1
kinetic law: MODEL1310110012#
is described by: ECO:0000269
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
is: SBO:0000176
fast: false
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.4.1.69
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110012#_4f5c5e36_79be_400e_8bf7_4de1c99f75df
type: Species
boundary condition: true
is encoded by: hsa:222
constant: false
initial amount: NaN
name: ALDH3B2
is: SBO:0000252
initial concentration: NaN
is: P48448
has only substance units: false

metaM HC01610 e
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28607
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
constant: false
name: CoproporphyrinogenI
has only substance units: false
type: Species

metaM CE4724 e
name: apelin (1-12)
initial amount: NaN
is: SBO:0000247
constant: false
is: C01936
boundary condition: false
notes: FORMULA: C60H105N22O15S CHARGE: 3 INCHI: InChI=1/C60H102N22O15S/c1-33(2)27-40(77-50(88)37(12-6-21-69-59(64)65)74-55(93)44-15-9-24-81(44)56(94)38(13-7-22-70-60(66)67)75-48(86)35(62)17-18-46(63)84)51(89)79-42(31-83)53(91)78-41(28-34-29-68-32-72-34)52(90)73-36(11-4-5-20-61)49(87)71-30-47(85)80-23-8-14-43(80)54(92)76-39(19-26-98-3)57(95)82-25-10-16-45(82)58(96)97/h29,32-33,35-45,83H,4-28,30-31,61-62H2,1-3H3,(H2,63,84)(H,68,72)(H,71,87)(H,73,90)(H,74,93)(H,75,86)(H,76,92)(H,77,88)(H,78,91)(H,79,89)(H,96,97)(H4,64,65,69)(H4,66,67,70)/p+3/t35-,36-,37-,38+,39-,40+,41+,42-,43+,44+,45-/m1/s1 EHMN_ABBREVIATION: CE4724
is: http://identifiers.org/pubchem.compound/5041
type: Species
initial concentration: 1.0
has only substance units: false

metaM cspg e l
boundary condition: false
type: Species
has only substance units: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
initial amount: NaN
is: CHEBI:36005
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB02183

metaM malthp e
is: C01936
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
initial concentration: 1.0
constant: false
name: maltoheptaose

metaR LCADi D
kinetic law: MODEL1310110012#
reversible: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.36
product: MODEL1310110012#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
modifier: MODEL1310110012#
reactant: MODEL1310110012#
name: lactaldehyde dehydrogenase

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_f94da7e0_6ca4_45f0_8416_75dbe5f23343
initial concentration: NaN
is: Q9NY65
name: EHHADH
has only substance units: false
boundary condition: true
is encoded by: hsa:1962
type: Species
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_93475221_074e_490d_8851_813af00f935f
initial concentration: NaN
is encoded by: hsa:22978
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: P49902
name: NT5C2
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110012#_d1784d2a_f548_44f6_8ea5_f4de47b53217
is: SBO:0000252
initial concentration: NaN
is: B2RB13
is encoded by: hsa:23305
initial amount: NaN
boundary condition: true
name: ACSL6
constant: false
type: Species
has only substance units: false

metaR r2447
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
name: Concentrative Nucleoside Transporter (CNT) TCDB:2.A.41.2.3
is described by: ECO:0000000
fast: false
product: MODEL1310110012#
is: SBO:0000185
reversible: false
reactant: MODEL1310110012#
type: Reaction

metaR FAOXC101x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)x
type: Reaction

metaR EX ksi deg1 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I, degradation product 1 exchange
type: Reaction

metaR DLNLCGCPT2
kinetic law: MODEL1310110012#
name: carnitine transferase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
is: SBO:0000176
reactant: MODEL1310110012#
type: Reaction
reversible: false

metaM pmtcrn x
name: L-palmitoylcarnitine
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00222
initial concentration: 1.0
constant: false
is: CHEBI:17490
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990

metaR KHte
fast: false
is described by: ECO:0000134
product: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
is: SBO:0000185
name: KHte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110012#_291b4944_135a_4b30_bdaf_4f568f1be4ac
constant: false
has only substance units: false
name: ALDOB
boundary condition: true
is: P05062
is encoded by: hsa:229
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

metaR MALtm
type: Reaction
is: SBO:0000185
name: malate transport, mitochondrial
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
product: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110012#_161efe3d_4413_43b3_8ab2_b79b893dc281
name: UPP1
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:7378
constant: false
is: SBO:0000252
is: Q16831

metaR SUCOASm
product: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
type: Reaction
reversible: true
is described by: ECO:0000000
name: Succinate--CoA ligase (ADP-forming)
is version of: http://identifiers.org/ec-code/6.2.1.5
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#

metaM ttdca e
is: HMDB00806
initial concentration: 1.0
is: C06424
boundary condition: false
is: SBO:0000247
is: CHEBI:30807
constant: false
name: tetradecanoate (n-C14:0)
type: Species
initial amount: NaN
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
has only substance units: false

metaM ksii core4 pre6 g
notes: FORMULA: C69H111N6O51SX CHARGE: -2
initial amount: NaN
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 6
constant: false
is: CHEBI:28067
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species

metaM dolp U c
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:57683
type: Species
name: dolichyl phosphate(2-)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_bd2044d6_17d3_49ba_b061_1ea758431786
is: Q16881
has only substance units: false
type: Species
name: TXNRD1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:7296

metaR G14T15g
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
product: MODEL1310110012#

metaM lnlccoa m
initial concentration: 1.0
is: HMDB01064
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
name: linoleic coenzyme A
constant: false
is: http://identifiers.org/pubchem.compound/5462164
type: Species
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983

metaM mal L m
is: HMDB00156
type: Species
name: (S)-malate(2-)
is: CHEBI:15589
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
initial amount: NaN
has only substance units: false

metaR DGCHOLte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is described by: ECO:0000000
reactant: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
fast: false
kinetic law: MODEL1310110012#
name: bile acid intracellular transport
is: SBO:0000185
reversible: true

metaR SUBERCACT
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_3a106d92_17ce_44bc_96d0_1aa192940208
constant: false
is: Q6FGV9
is encoded by: hsa:10654
boundary condition: true
has only substance units: false
name: PMVK
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaM xol7ah3 m
initial concentration: 1.0
has only substance units: false
is: CHEBI:28540
boundary condition: false
is: HMDB12455
type: Species
constant: false
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha,26-triol
initial amount: NaN
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444

http://identifiers.org/biomodels.db/MODEL1310110012#_25dd7793_86ab_4598_b3f3_a6c8abf09320
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:3795
constant: false
is: Q6IBK2
name: KHK
boundary condition: true

metaR r2420
reactant: MODEL1310110012#
is: SBO:0000185
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
fast: false
type: Reaction
kinetic law: MODEL1310110012#
reversible: true

metaR RE0915E
kinetic law: MODEL1310110012#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1
name: RE0915
is described by: ECO:0000000
fast: false
product: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
type: Reaction
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110012#_4264fe2e_76b7_4d65_9040_cd9d0c85cc2b
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4715
is: SBO:0000252
name: NDUFB9
type: Species
is: Q9Y6M9

metaR EX c81crn
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octenoyl carnitine
type: Reaction

metaM memgacpail hs r
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
is: HMDB00054
is: CHEBI:57977
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_23a12396_1eca_4416_97c0_2bfd62ba1e0c
has only substance units: false
boundary condition: true
type: Species
constant: false
is encoded by: hsa:AI348006
initial concentration: NaN
is: SBO:0000252
name: _AI348006_1_c
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_f32c1490_e7b0_4d61_98ff_5abbf69bba25
constant: false
type: Species
is: B4DH54
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: GK
initial concentration: NaN
is encoded by: hsa:2710
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_65cb8a0a_8f39_4476_ba10_f686dcab05e0
constant: false
initial concentration: NaN
is encoded by: hsa:54511
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q9NT06
name: HMGCLL1
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_b1be74bf_c5d7_43c8_81b6_952c89ad7714
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
is: Q76EJ3
is encoded by: hsa:11046
has only substance units: false
name: SLC35D2
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_ff359097_9623_4a90_a4bb_455b7236757a
is encoded by: hsa:4702
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: B1AM93
type: Species
constant: false
name: NDUFA8
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_07ba2fd3_b42c_42e7_9b81_c8193c53c983
name: CROT
is: SBO:0000252
is encoded by: hsa:54677
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: E7EQF2
type: Species

metaM na1 x
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00588
name: sodium(1+)
boundary condition: false
initial amount: NaN
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
type: Species
is: CHEBI:29101
constant: false

metaM 3ivcrn c
constant: false
is: http://identifiers.org/pubchem.compound/11966188
boundary condition: false
is: HMDB06870
initial amount: NaN
name: 3-hydroxy-isovaleryl carnitine
initial concentration: 1.0
is: SBO:0000247
is: C05998
notes: FORMULA: C12H23NO5 CHARGE: 0
type: Species
has only substance units: false

metaR EX tetdece1crn
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_c5172c4e_d5e4_4e57_88ab_0c19e22d7cd8
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:BC005314
initial concentration: NaN
name: _BC005314_1_x
type: Species

metaR DM 4abut LPAREN n RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID: 16643338 NOTES:GABA in the intestine may aid in differentiation and proliferation of epithelial cells. GABA intake by oral administration has been shown to alleviate stress, worry and anxiety and additionally it can also improve human immunity (PMID: 16971751). However the PAT1 transporter located at the apical side of enterocytes have very low affinity for GABA. I have presumed that this oral GABA is used within intestine (unless administered at high very high pharmacological doses, GABA exit from the enterocytes may be mediated by other specifc transporters).
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for 4-Aminobutanoate(n)
type: Reaction

metaR PDE4
fast: false
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.17
product: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.35
reactant: MODEL1310110012#
name: 3',5'-cyclic-nucleotide phosphodiesterase
kinetic law: MODEL1310110012#
is: SBO:0000176

metaR RE3000M
is described by: ECO:0000000
name: RE3000
type: Reaction
reactant: MODEL1310110012#
product: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
reversible: true
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176

metaM h2o n
has only substance units: false
initial concentration: 1.0
name: water
is: CHEBI:15377
is: SBO:0000247
boundary condition: false
is: HMDB02111
type: Species
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_565bd89f_36f3_4697_98c5_e534bb891d54
is: SBO:0000252
initial amount: NaN
name: GLDC
has only substance units: false
is: P23378
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:2731
constant: false

metaM 3dphb m
initial amount: NaN
is: HMDB06251
boundary condition: false
name: 3-Decaprenyl-4-hydroxybenzoate
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C57H85O3 CHARGE: -1 INCHI: InChI=1/C57H86O3/c1-44(2)21-12-22-45(3)23-13-24-46(4)25-14-26-47(5)27-15-28-48(6)29-16-30-49(7)31-17-32-50(8)33-18-34-51(9)35-19-36-52(10)37-20-38-53(11)39-40-54-43-55(57(59)60)41-42-56(54)58/h21,23,25,27,29,31,33,35,37,39,41-43,58H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,59,60)/b45-23+,46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+
type: Species

metaR AG13T7g
product: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
modifier: MODEL1310110012#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
fast: false
reversible: false

metaM pro D e
initial concentration: 1.0
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: HMDB03411
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
name: D-proline
has only substance units: false
is: CHEBI:16313

http://identifiers.org/biomodels.db/MODEL1310110012#_e9431554_d1b9_4bbf_8640_a957a37bfd4b
initial amount: NaN
has only substance units: false
name: DGUOK
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:1716
initial concentration: NaN
is: E5KSL6
type: Species

metaR AHEXASE2ly
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000176
product: MODEL1310110012#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
is described by: ECO:0000000
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR S6TASE19ly
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110012#
reactant: MODEL1310110012#
product: MODEL1310110012#
reversible: true
fast: false

metaM dadp m
constant: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
has only substance units: false
is: HMDB01508
is: SBO:0000247
is: CHEBI:57667
initial amount: NaN
name: dADP(3-)
initial concentration: 1.0
type: Species
boundary condition: false

metaR H2CO3D
is: SBO:0000176
fast: false
product: MODEL1310110012#
modifier: MODEL1310110012#
reactant: MODEL1310110012#
reversible: true
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.1
name: carboxylic acid dissociation

http://identifiers.org/biomodels.db/MODEL1310110012#_094ce6f4_6b7f_45b9_949f_dc875f429230
initial amount: NaN
is: Q9NQU1
type: Species
initial concentration: NaN
is encoded by: hsa:65010
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
name: SLC26A6

metaM ppi e
constant: false
is: C00013
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:33019
type: Species
boundary condition: false
name: Diphosphate
is: SBO:0000247
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013

http://identifiers.org/biomodels.db/MODEL1310110012#_022009fa_a16f_47ff_bd90_80221bc56a10
is encoded by: hsa:3284
constant: false
boundary condition: true
initial concentration: NaN
is: P26439
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: HSD3B2

metaM h2o m
initial amount: NaN
has only substance units: false
is: CHEBI:15377
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB02111
is: C00001
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
type: Species
name: H2O

http://identifiers.org/biomodels.db/MODEL1310110012#_72428160_cea1_408a_bfa4_a11747418248
name: PFKFB3
is: Q16875
initial concentration: NaN
constant: false
is encoded by: hsa:5209
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species

metaR BAAT4x
reactant: MODEL1310110012#
name: bile acid Coenzyme A: amino acid N-acyltransferase
type: Reaction
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:fourth version analog added in similarity to BAAT1x, BAAT2x NJ
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110012#
fast: false
reversible: false
product: MODEL1310110012#
is described by: ECO:0000304
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110012#_e9f39a4d_0109_48c0_8423_1a9590f2bdfd
is: Q9P2X0
initial amount: NaN
type: Species
is encoded by: hsa:54344
is: SBO:0000252
name: DPM3
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_c5d4ba36_2961_48d1_9b97_45d3411677cf
name: GNPDA2
initial amount: NaN
is encoded by: hsa:132789
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is: Q8TDQ7
initial concentration: NaN
type: Species

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaR CYTK5n
fast: false
modifier: MODEL1310110012#
name: cytidylate kinase (CMP),nuclear
is: SBO:0000176
kinetic law: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110012#
product: MODEL1310110012#

metaM arachcrn c
type: Species
is: HMDB06460
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: arachidyl carnitine
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_95dba5ae_8329_4817_8e10_a5a06e6b31d6
initial concentration: NaN
initial amount: NaN
constant: false
name: IDH1
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is: O75874
is encoded by: hsa:3417

metaM dadp n
initial concentration: 1.0
is: HMDB01508
name: dADP(3-)
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:57667
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
type: Species
constant: false

metaR EX leuleu LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylleucine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_b8324d7a_8904_4de7_ae2e_c733051edbec
type: Species
is: Q13454
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:7991
name: TUSC3

metaR FADH2tx
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
type: Reaction
is described by: ECO:0000000
product: MODEL1310110012#
kinetic law: MODEL1310110012#
name: FADH2 transporter, peroxisomal
reactant: MODEL1310110012#
reversible: true

metaM cspg e e
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16040
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
constant: false
is: HMDB00630
type: Species

metaR GALSGLT1le
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-Galactose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

metaM CE5868 e
is: CHEBI:27485
is: HMDB02710
notes: FORMULA: C9H12N2O7 CHARGE: -2 INCHI: InChI=1/C9H14N2O7/c1-4(13)10-6(3-12)8(16)11-5(9(17)18)2-7(14)15/h5-6,12H,2-3H2,1H3,(H,10,13)(H,11,16)(H,14,15)(H,17,18)/p-2/t5-,6+/m1/s1 EHMN_ABBREVIATION: CE5868
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: N-acetyl-seryl-aspartate
constant: false
boundary condition: false

metaM h2o l
is: CHEBI:15377
initial amount: NaN
is: HMDB02111
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
name: water
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
boundary condition: false

metaM idour l
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: HMDB02704
type: Species
name: L-iduronate
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:21338
initial concentration: 1.0

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaM pro D c
is: HMDB03411
has only substance units: false
type: Species
name: D-proline
is: SBO:0000247
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:16313
initial concentration: 1.0

metaR HIVCACBP
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyisovalerylcoa from mitochondria into the cytosol
type: Reaction

metaM lgnccoa x
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB06526
boundary condition: false
name: lignocericyl coenzyme A
has only substance units: false
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
type: Species

metaM thexddcoa m
type: Species
notes: FORMULA: C37H58N7O17P3S CHARGE: -4
boundary condition: false
name: trans7,10-hexadecadienoylcoa
is: HMDB02288
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false

metaM ksii core4 deg3 l
initial concentration: 1.0
is: HMDB00143
constant: false
type: Species
name: keratan sulfate II (core 4-linked), degradation product 3
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
is: CHEBI:12936

metaR PDE1
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.1.4.35
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.17
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
type: Reaction
reversible: false
name: 3',5'-cyclic-nucleotide phosphodiesterase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_3817fd62_ec8c_41b8_a450_db3df6b0d056
constant: false
name: GCNT3
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:9245
boundary condition: true
initial concentration: NaN
type: Species
is: O95395

http://identifiers.org/biomodels.db/MODEL1310110012#_237febdc_49b5_493a_aea8_2eea3b88ed9c
is encoded by: hsa:10317
initial amount: NaN
has only substance units: false
boundary condition: true
name: B3GALT5
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_b8664609_d3c0_432c_ae31_45c3cdb3dff5
name: LDHD
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:197257
is: SBO:0000252
is: Q86WU2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_93667a96_2793_41dd_9948_4b3bc8256558
is: Q86SR1
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
name: GALNT10
initial amount: NaN
is encoded by: hsa:55568
type: Species

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_6e429e02_a27e_45dc_9623_96143216dc4f
initial concentration: NaN
constant: false
is: SBO:0000252
name: PRPS2
is encoded by: hsa:5634
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: P11908

metaR EX appnn LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (+)-alpha-Pinene exchange
type: Reaction

metaM homoval m
initial concentration: 1.0
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
is: SBO:0000247
type: Species
name: Homovanillate
has only substance units: false
constant: false
boundary condition: false
is: HMDB00118
is: CHEBI:545959
initial amount: NaN

metaR FAOXC160
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110012#
product: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reactant: MODEL1310110012#
reversible: false
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
type: Reaction
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaR MMSAD1m
kinetic law: MODEL1310110012#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.27
product: MODEL1310110012#
is: SBO:0000176
name: methylmalonate-semialdehyde dehydrogenase
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
is described by: ECO:0000269
modifier: MODEL1310110012#
reactant: MODEL1310110012#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_96966de6_460c_4454_b663_c02d5cfa359a
is encoded by: hsa:2983
has part: Q02153
initial concentration: NaN
boundary condition: true
has part: P33402
type: Species
initial amount: NaN
is encoded by: hsa:2977
constant: false
name: GUCY1A2:GUCY1B3
is: SBO:0000297
has only substance units: false

metaR SPODMx
product: MODEL1310110012#
reversible: false
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.15.1.1
type: Reaction
name: superoxide dismutase, peroxisome
modifier: MODEL1310110012#
is: SBO:0000176
reactant: MODEL1310110012#

metaM m4mpdol U c
boundary condition: false
constant: false
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
initial amount: NaN
is: CHEBI:37633
type: Species
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_8f75792e_718b_429f_84c3_2204c27843e8
name: AMPD1
is: SBO:0000252
is encoded by: hsa:270
type: Species
constant: false
boundary condition: true
is: P23109
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM 5HPET c
is: CHEBI:57450
is: SBO:0000247
name: 5(S)-HPETE(1-)
is: HMDB01193
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_256be63e_399e_4af1_b26f_b88d9a26d33d
initial amount: NaN
is encoded by: hsa:4722
has only substance units: false
name: NDUFS3
constant: false
initial concentration: NaN
is: O75489
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_dd567104_b0ad_42b7_822c_0363534f4d7e
boundary condition: true
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:10195
initial concentration: NaN
initial amount: NaN
name: ALG3

metaM f6p c
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/3385
is: SBO:0000247
is: HMDB00124
name: D-Fructose 6-phosphate
is: CHEBI:57579
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: C00085

metaR RE2649M
reactant: MODEL1310110012#
name: RE2649
notes: GENE_ASSOCIATION: (10965.1) or (11332.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:IT - fixed proton
is described by: ECO:0000000
reversible: true
is: SBO:0000176
modifier: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_4ae63a63_7305_46e0_9fd0_a2b18d027614
is encoded by: hsa:8876
boundary condition: true
name: VNN1
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is: O95497
initial concentration: NaN

metaM m5mpdol U r
has only substance units: false
initial amount: NaN
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247
constant: false
is: CHEBI:37634
type: Species
notes: FORMULA: C1545H2540N20O470P20 CHARGE: -20
initial concentration: 1.0
boundary condition: false

metaR FTHFCL
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (10588.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 4 AUTHORS: PMID:12764149 NOTES:NCD
reactant: MODEL1310110012#
fast: false
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.3.3.2
product: MODEL1310110012#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110012#
name: 5-formethyltetrahydrofolate cyclo-ligase

metaR GLCNACT U
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110012#
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (uterus)
reactant: MODEL1310110012#
reversible: false
kinetic law: MODEL1310110012#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110012#_20c4ce42_4ae7_4005_b58b_8c58ceb84cae
initial concentration: NaN
has only substance units: false
name: AKR1A1
boundary condition: true
initial amount: NaN
is encoded by: hsa:10327
type: Species
is: SBO:0000252
constant: false

metaM dcyt c
has only substance units: false
is: C00881
initial amount: NaN
is: CHEBI:15698
is: SBO:0000247
constant: false
initial concentration: 1.0
name: Deoxycytidine
boundary condition: false
is: HMDB00014
type: Species
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881

metaR r0575
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.48
is: SBO:0000176
modifier: MODEL1310110012#
type: Reaction

metaM acgam c
is: SBO:0000247
has only substance units: false
name: N-acetyl-D-glucosamine
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00215
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: CHEBI:17411
constant: false
initial concentration: 1.0

metaR r0361
notes: GENE_ASSOCIATION: (5009.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is version of: http://identifiers.org/ec-code/2.1.3.3
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
product: MODEL1310110012#
is described by: ECO:0000000
reversible: false
fast: false
modifier: MODEL1310110012#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_7e4daf52_933e_4743_a40a_1d80bdceb8a5
constant: false
type: Species
has only substance units: false
is encoded by: hsa:50808
initial concentration: NaN
boundary condition: true
is: E7ET30
initial amount: NaN
is: SBO:0000252
name: AK3

metaR ARGt4
fast: false
is: SBO:0000185
reversible: false
type: Reaction
name: L-arginine transport in via sodium symport
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000304
kinetic law: MODEL1310110012#

metaR HACD1m
type: Reaction
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
is described by: ECO:0000134
fast: false
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000176
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110012#
reversible: true

metaR FRDPtr
is described by: ECO:0000000
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
is: SBO:0000185
kinetic law: MODEL1310110012#
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110012#
reversible: true
type: Reaction
fast: false

metaR EX but LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Butyrate (n-C4:0) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_f722dce6_71ba_4845_acf1_e3ad7cba40dc
is encoded by: hsa:10317
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9Y2C3
name: B3GALT5
constant: false
boundary condition: true
has only substance units: false

metaM 3hexdcoa m
type: Species
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
is: C05258
name: 3-hydroxyhexadecanoylcoa
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
is: HMDB03932
has only substance units: false
initial amount: NaN

metaR r1527
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
modifier: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110012#
reversible: false
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/4.2.1.1

metaM Lkynr c
type: Species
is: HMDB00684
constant: false
is: CHEBI:16946
is: SBO:0000247
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
initial concentration: 1.0
name: L-kynurenine
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_3f25140e_5ea8_4b11_babb_d3d565d969e7
boundary condition: true
initial concentration: NaN
name: _AA081045_1_m
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:AA081045
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110012#_c2536fcc_93f0_4d6b_b6e6_f24b893b7515
is: SBO:0000252
initial concentration: NaN
constant: false
name: FUT8
is encoded by: hsa:2530
boundary condition: true
has only substance units: false
is: A8K8P8
type: Species
initial amount: NaN

metaM dhcrm hs c
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
has only substance units: false
initial amount: NaN
is: CHEBI:31488
name: dihydroceramide
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
type: Species

metaR O2Stm
name: superoxide anion transport via diffusion (mitochondria)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
reactant: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#

metaR r1428
is: SBO:0000185
fast: false
kinetic law: MODEL1310110012#
name: Free diffusion
product: MODEL1310110012#
reversible: true
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
is described by: ECO:0000000
type: Reaction

metaM thf m
name: 5,6,7,8-Tetrahydrofolate
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: C00101
constant: false
has only substance units: false
is: CHEBI:57453
is: HMDB01846
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR GLCNACPT U
product: MODEL1310110012#
reversible: false
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (uterus)
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.8.15
type: Reaction

metaM cs e deg2 l
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16953
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
initial amount: NaN
constant: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
is: HMDB00812

metaM acgbgbside hs c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
has only substance units: false
is: CHEBI:17411
constant: false
is: HMDB00215
name: beta GalNAc globoside

metaR r0360
modifier: MODEL1310110012#
is described by: ECO:0000000
reactant: MODEL1310110012#
is: SBO:0000176
product: MODEL1310110012#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.16
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
fast: false
kinetic law: MODEL1310110012#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1

metaR BACCLm
fast: false
is described by: ECO:0000254
is: SBO:0000176
product: MODEL1310110012#
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
kinetic law: MODEL1310110012#
reversible: false
is version of: http://identifiers.org/ec-code/6.3.4.10
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
type: Reaction
modifier: MODEL1310110012#
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_63b8c28f_b854_40a9_beee_de475ddfec88
is encoded by: hsa:4704
initial amount: NaN
is: Q16795
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: NDUFA9
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_1b95ec13_2489_4188_ae0a_880f0dce4c05
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:93010
constant: false
boundary condition: true
name: B3GNT7
initial concentration: NaN
is: Q8NFL0

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_abe3b6ee_7a9f_4ecb_9779_af0890ce6a98
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
name: ATP5H
has only substance units: false
is: O75947
is encoded by: hsa:10476
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110012#_7fd3bd81_4452_4f97_87c5_d76cb659f8f9
is: P18545
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:5148
is: SBO:0000252
constant: false
name: PDE6G

http://identifiers.org/biomodels.db/MODEL1310110012#_885a21ec_c8a8_45eb_8f95_47475f5ec072
type: Species
boundary condition: true
is encoded by: hsa:2271
is: P07954
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: FH
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110012#_c5066dba_4954_4563_92e8_306f2d673f65
is: SBO:0000252
is encoded by: hsa:5287
has only substance units: false
type: Species
is: O00750
initial concentration: NaN
constant: false
boundary condition: true
name: PIK3C2B
initial amount: NaN

metaM sphs1p r
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: CHEBI:60119
initial concentration: 1.0
type: Species
name: sphingosine 1-phosphate(1-)
is: HMDB00277
has only substance units: false
boundary condition: false

metaR sink tetdec2coa LPAREN c RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDEC2COASINK
type: Reaction

metaR r1429
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
name: Free diffusion
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_86b93a5b_56f5_4e1b_a3f8_fae4d4b2f427
initial concentration: NaN
boundary condition: true
constant: false
name: GCDH
type: Species
initial amount: NaN
is encoded by: hsa:2639
is: SBO:0000252
has only substance units: false

metaR r0990
name: Postulated transport reaction
is: SBO:0000185
reactant: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_6b69fcae_60cd_4f08_886a_2cd8f911f35c
is: Q9H553
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:85365
constant: false
is: SBO:0000252
name: ALG2
initial concentration: NaN

metaM retinal cis 9 c
initial concentration: 1.0
is: HMDB01358
is: CHEBI:17898
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
constant: false
type: Species
name: all-trans-retinal

http://identifiers.org/biomodels.db/MODEL1310110012#_f88d9dbd_89e2_4419_93b1_12dd1d3b2191
constant: false
name: ACP6
is: SBO:0000252
has only substance units: false
is: Q9NPH0
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:51205
initial amount: NaN

metaR GALGALGALTHCRMte
product: MODEL1310110012#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
fast: false
reactant: MODEL1310110012#
is: SBO:0000185
kinetic law: MODEL1310110012#
name: galgalgalthcrm hs transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_268f32ef_b2be_458a_991b_c8dfb794c5f2
initial concentration: NaN
constant: false
has only substance units: false
name: XDH
initial amount: NaN
is encoded by: hsa:7498
boundary condition: true
is: P47989
is: SBO:0000252
type: Species

metaR ACP1 FMN
notes: GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:8522318 NOTES:INVALID ECO TERM: IFH
is: SBO:0000176
is described by: ECO:0000254
modifier: MODEL1310110012#
type: Reaction
fast: false
product: MODEL1310110012#
name: acid phosphatase (FMN)
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.1.3.2
kinetic law: MODEL1310110012#
reversible: false

metaR r0995
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
is described by: ECO:0000000
reactant: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is: SBO:0000185
product: MODEL1310110012#

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

metaR HSD17B42x
is described by: ECO:0000269
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
modifier: MODEL1310110012#
name: hydroxysteroid (17-beta) dehydrogenase 4
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
reversible: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false

metaR SERGLNNaEx
type: Reaction
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
reversible: false
is: SBO:0000185
name: L-serine/L-glutamine Na-dependent exchange (Ser-L in)

http://identifiers.org/biomodels.db/MODEL1310110012#_709f4ef0_356c_49b3_a114_2d13ed14b078
initial amount: NaN
type: Species
is encoded by: hsa:55276
is: Q96G03
name: PGM2
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_15762138_d8e0_43af_8c58_ce28d2676bde
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is: P04054
has only substance units: false
initial amount: NaN
name: PLA2G1B
is encoded by: hsa:5319

metaR FAOXC227C226m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_39ff6376_b879_49d8_9f44_749130eae6dd
is: SBO:0000252
is: Q92820
initial amount: NaN
name: GGH
constant: false
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:8836

http://identifiers.org/biomodels.db/MODEL1310110012#_86dc2e6c_131d_47b9_9c06_2002209116d8
initial concentration: NaN
is: Q13613
name: MTMR1
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:8776

metaM HC00250 c
boundary condition: false
has only substance units: false
is: CHEBI:29919
name: hydrosulfide
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
constant: false
initial concentration: 1.0

metaR GALASE16ly
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
name: beta-galactosidase, lysosomal
fast: false
type: Reaction
reversible: false
product: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#

metaR EX galgalgalthcrm hs LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer (homo sapiens) exchange
type: Reaction

metaR r0797
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
name: glycine N-choloyltransferase EC:2.3.1.65
reversible: true
type: Reaction
is: SBO:0000176
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000000
kinetic law: MODEL1310110012#

metaR BTNDm
is described by: ECO:0000269
reversible: false
name: biotinidase (biotin), mitochondrial
fast: false
reactant: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.5.1.12

http://identifiers.org/biomodels.db/MODEL1310110012#_3748c4f2_ed22_48c6_92d1_a0c46aec88f0
is encoded by: hsa:6582
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: SLC22A2

metaM lnlc e
constant: false
has only substance units: false
initial concentration: 1.0
name: linoleate
is: CHEBI:30245
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: HMDB00673
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_d4fb25c9_d030_4e6d_8637_e09c6a92e0f5
type: Species
is encoded by: hsa:6309
initial concentration: NaN
is: Q6GTM5
name: SC5DL
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN

metaM no e
has only substance units: false
is: SBO:0000247
is: HMDB03378
is: CHEBI:16480
constant: false
boundary condition: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
name: Nitric oxide
type: Species
initial amount: NaN
is: C00533
initial concentration: 1.0

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaM HC02175 c
has only substance units: false
name: caprate
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:27689
type: Species
initial concentration: 1.0
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
boundary condition: false

metaR CYANt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
reactant: MODEL1310110012#
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110012#
kinetic law: MODEL1310110012#
name: Cyanide transport via diffusion (extracellular to cytosol)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_7b236644_fad0_426d_9a3d_edeebe0f1282
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
name: CYP2C8
constant: false
is encoded by: hsa:1558
initial concentration: NaN
is: B7Z1F5

http://identifiers.org/biomodels.db/MODEL1310110012#_816d59f8_6d56_49fa_911a_c92326f50e95
has only substance units: false
initial concentration: NaN
is: P08559
is: SBO:0000252
type: Species
constant: false
boundary condition: true
name: PDHA1
initial amount: NaN
is encoded by: hsa:5160

metaR RPEc
product: MODEL1310110012#
fast: false
name: ribulose 5-phosphate 3-epimerase
reactant: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
kinetic law: MODEL1310110012#
reversible: true
is described by: ECO:0000134
is: SBO:0000176

metaM CE4876 r
name: delta12-Prostaglandin J2
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:57923

metaR KCC2t
name: K+-Cl- cotransporter (NH4+)
modifier: MODEL1310110012#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110012#
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
kinetic law: MODEL1310110012#
product: MODEL1310110012#

metaR r0796
fast: false
is: SBO:0000176
modifier: MODEL1310110012#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
reversible: true
product: MODEL1310110012#
type: Reaction

metaR RE3301C
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
kinetic law: MODEL1310110012#
reversible: true
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000176
name: RE3301
type: Reaction
fast: false
product: MODEL1310110012#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.4.4

metaM pi x
initial amount: NaN
is: CHEBI:43474
constant: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: hydrogenphosphate
boundary condition: false
type: Species
is: HMDB00973

metaR GALGALGALTHCRMtg
product: MODEL1310110012#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reactant: MODEL1310110012#
is: SBO:0000185
name: galgalgalthcrm hs intracellular transport
kinetic law: MODEL1310110012#
type: Reaction
is described by: ECO:0000000

metaM btcoa m
is: HMDB01088
is: CHEBI:57371
initial amount: NaN
has only substance units: false
type: Species
is: C00136
constant: false
boundary condition: false
is: SBO:0000247
name: Butanoyl-CoA
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
initial concentration: 1.0

metaR HTDCRNe
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-tetradecanoyl carnitine into extra cellular space
type: Reaction

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaR DOCO13ECOAtxc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 13-docosenoylcoa into peroxisomes
type: Reaction

metaR FAOXC225m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

metaM nrpphr e
is: HMDB00216
initial amount: NaN
type: Species
is: CHEBI:33569
initial concentration: 1.0
name: Norepinephrine
boundary condition: false
constant: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: SBO:0000247
has only substance units: false

metaM acgbgbside hs g
constant: false
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
boundary condition: false
is: CHEBI:17411
has only substance units: false
is: HMDB00215
is: SBO:0000247
name: beta GalNAc globoside
type: Species
initial concentration: 1.0
initial amount: NaN

metaR RE0958E
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110012#
modifier: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
name: RE0958

metaR r0570
reversible: true
is version of: http://identifiers.org/ec-code/6.3.3.2
is described by: ECO:0000000
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000176
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
type: Reaction
product: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_75b68c4f_9a5e_4f11_8bf1_c88340391fa1
name: INPP4A
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3631
type: Species
boundary condition: true
initial concentration: NaN
is: Q96PE3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_317074b7_4a18_4fcd_9330_263072a968b7
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is: O95436
is encoded by: hsa:10568
initial amount: NaN
type: Species
name: SLC34A2

http://identifiers.org/biomodels.db/MODEL1310110012#_22755a23_eeb4_450f_a525_8d762b15dd4c
has only substance units: false
is: SBO:0000252
name: NNT
initial concentration: NaN
boundary condition: true
is encoded by: hsa:23530
type: Species
initial amount: NaN
constant: false

metaR r0994
fast: false
kinetic law: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
name: Facilitated diffusion
reactant: MODEL1310110012#

metaM HC00250 e
type: Species
constant: false
has only substance units: false
name: hydrosulfide
is: CHEBI:29919
initial amount: NaN
boundary condition: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: SBO:0000247
initial concentration: 1.0

metaM tmndnccoa x
is: HMDB06514
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
boundary condition: false
type: Species
name: timnodonyl coenzyme A

metaM 3dodtricoa m
is: C05279
is: HMDB11123
initial concentration: 1.0
has only substance units: false
type: Species
name: 3,6,9-dodecatrienoylcoa
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C33H48N7O17P3S CHARGE: -4

metaR GLUt2m
reversible: true
fast: false
name: L-glutamate reversible transport via proton symport, mitochondrial
is described by: ECO:0000269
reactant: MODEL1310110012#
product: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (83733.1) or (8604.1) or (79751.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110012#

metaM no c
constant: false
boundary condition: false
name: Nitric oxide
is: C00533
has only substance units: false
type: Species
is: HMDB03378
initial concentration: 1.0
is: CHEBI:16480
is: SBO:0000247
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
initial amount: NaN

metaM gdpddman c
has only substance units: false
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222
initial concentration: 1.0
type: Species
is: CHEBI:57964
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB01346

http://identifiers.org/biomodels.db/MODEL1310110012#_8443f5fe_beb5_49d4_be9b_c43aeb09bfdc
is encoded by: hsa:6391
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is: Q99643
name: SDHC
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_9fa185d7_62b3_4ec8_9574_a9666b3e24e9
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2882
type: Species
is: Q96SL4
constant: false
name: GPX7

http://identifiers.org/biomodels.db/MODEL1310110012#_5bef890a_90a1_4974_8ce2_d538335b7d18
initial amount: NaN
name: ALG1
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:56052
is: Q9BT22

metaM ocde9ecoa x
type: Species
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
name: 9-octadecenoylcoa
is: SBO:0000247
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false
initial concentration: 1.0

metaM pail4p hs n
has only substance units: false
is: SBO:0000247
is: CHEBI:58178
type: Species
initial amount: NaN
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
boundary condition: false
initial concentration: 1.0
constant: false

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_13f6f303_936e_4955_b4be_538361685d22
initial amount: NaN
is: Q9H477
type: Species
has only substance units: false
is encoded by: hsa:64080
initial concentration: NaN
constant: false
boundary condition: true
name: RBKS
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110012#_e6fc44fd_76b7_4717_80eb_2e34ec01b217
boundary condition: true
is encoded by: hsa:217
has only substance units: false
is: SBO:0000252
name: ALDH2
initial concentration: NaN
is: P05091
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_6d17ed75_b16f_461d_8a6b_9b65daa41727
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AA177072
boundary condition: true
has only substance units: false
type: Species
name: _AA177072_1_c
constant: false

metaM galside hs l
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:12947
constant: false
name: D-galactosyl-N-acylsphingosine
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR FAOXTC142TC122m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C14:2-->C12:2)m
type: Reaction

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_a9f1d113_69f4_4511_a6fb_ad7972f60ec2
name: HMOX2
is encoded by: hsa:3163
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is: P30519
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_a7cbf816_1cb4_4e0a_a963_f0b757f4217b
name: GGT1
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:2678
initial amount: NaN

metaM nrpphr c
has only substance units: false
name: Norepinephrine
type: Species
is: SBO:0000247
is: HMDB00216
is: CHEBI:33569
constant: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM pi r
is: C00009
initial concentration: 1.0
initial amount: NaN
is: HMDB00973
boundary condition: false
is: CHEBI:43474
type: Species
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
name: hydrogenphosphate
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_8e2e304c_0b68_4e93_bd89_5f628d25a442
constant: false
is encoded by: hsa:1109
name: AKR1C4
boundary condition: true
type: Species
is: P17516
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_ecf89edc_dce5_4c85_9373_ebeb063bc065
initial concentration: NaN
is: P15328
has only substance units: false
is encoded by: hsa:2348
name: FOLR1
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species

metaR 4MTOLBUTAMIDEte
is: SBO:0000185
reversible: true
reactant: MODEL1310110012#
is described by: ECO:0000000
name: xenobiotic transport
kinetic law: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
fast: false

metaR r0999
is: SBO:0000185
reactant: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Facilitated diffusion
product: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
type: Reaction
is described by: ECO:0000000

metaM prostge1 c
type: Species
is: CHEBI:57397
boundary condition: false
has only substance units: false
name: prostaglandin E1(1-)
is: HMDB01442
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: SBO:0000247
initial amount: NaN
constant: false

metaR PYDAMK
is version of: http://identifiers.org/ec-code/2.7.1.35
reversible: false
reactant: MODEL1310110012#
product: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110012#
name: pyridoxamine kinase
fast: false
is: SBO:0000176
type: Reaction

metaR DM T antigen g
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

metaR r1318
is: SBO:0000185
name: Transport reaction
fast: false
kinetic law: MODEL1310110012#
reversible: true
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110012#
type: Reaction

metaR SPODMn
is described by: ECO:0000269
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.15.1.1
modifier: MODEL1310110012#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
reactant: MODEL1310110012#
reversible: false
name: superoxide dismutase, nuclear

http://identifiers.org/biomodels.db/MODEL1310110012#_8f7ff8d1_6c7a_45a6_8456_65c8c93a61f9
constant: false
is: Q8IYH3
is: SBO:0000252
type: Species
name: HAS1
initial amount: NaN
is encoded by: hsa:3036
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR SFCYSc
reversible: true
reactant: MODEL1310110012#
is: SBO:0000176
name: Formation of sulfocysteine
type: Reaction
kinetic law: MODEL1310110012#
fast: false
is described by: ECO:0000134
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID: 2621485 NOTES:non-enzymatic reaction. Sulfocysteine is excreted in the urine.One proton added for elemental balancing.

metaM ksi deg11 l
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: CHEBI:12936
boundary condition: false
initial concentration: 1.0
is: HMDB00143
name: keratan sulfate I, degradation product 11
is: SBO:0000247
notes: FORMULA: C180H289N12O158S9 CHARGE: -9

metaR DSAT
is: SBO:0000176
type: Reaction
reversible: false
fast: false
name: dihydrosphingosine N-acyltransferase
reactant: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
kinetic law: MODEL1310110012#
is described by: ECO:0000000

metaM cs b l
is: HMDB02183
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:36005
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C45H66N2O49S4 CHARGE: -6

http://identifiers.org/biomodels.db/MODEL1310110012#_72de08be_54c8_47ef_af99_8d22b4129cc9
name: IVD
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: B3KVI7
is encoded by: hsa:3712
type: Species
initial amount: NaN
constant: false

metaR SAMHISTA
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.1.8
modifier: MODEL1310110012#
name: S-Adenosyl-L-methionine:histamine N-tele-methyltransferase
notes: GENE_ASSOCIATION: (3176.1) SUBSYSTEM: Histidine metabolism EC Number: 2.1.1.8 Confidence Level: 4 AUTHORS: PMID:7943261 NOTES:SAB R02155
kinetic law: MODEL1310110012#
fast: false
reversible: false
is: SBO:0000176
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110012#_5d837d07_30fc_4778_bdf1_0bd360449789
boundary condition: true
is: P21108
type: Species
constant: false
initial amount: NaN
name: PRPS1L1
is encoded by: hsa:221823
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110012#_7e9302fd_ea5e_4419_a11e_697fbc4034b3
constant: false
is: Q67FW5
is encoded by: hsa:146712
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
name: B3GNTL1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_b7b76a93_6119_4a74_b359_2d0b6c40e179
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is: Q9H6Y6
initial amount: NaN
is encoded by: hsa:4645
name: MYO5B
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_eeaee82c_7408_4b50_a76b_5e4ad80e160b
constant: false
has only substance units: false
is encoded by: hsa:2629
is: B7Z6S9
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
name: GBA

http://identifiers.org/biomodels.db/MODEL1310110012#_8fb085bc_f837_4c4e_b1c2_3653ccefab70
is: SBO:0000252
is: P28330
boundary condition: true
constant: false
name: ACADL
is encoded by: hsa:33
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false

metaR PAIL45P HStn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110012#
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
is: SBO:0000185
fast: false
kinetic law: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#

metaR ACOAD1fm
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
reversible: false
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
is described by: ECO:0000269
reactant: MODEL1310110012#
is: SBO:0000176
kinetic law: MODEL1310110012#
product: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.3.8.1

metaR DNDPt29m
reversible: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110012#
is: SBO:0000185
product: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
modifier: MODEL1310110012#
name: dCDP transport via dADP antiport

metaM adn c
type: Species
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
constant: false
is: CHEBI:16335
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00050
is: C00212
is: SBO:0000247
boundary condition: false
name: Adenosine

metaR KCCt
reversible: true
name: K+-Cl- cotransport
reactant: MODEL1310110012#
is: SBO:0000185
product: MODEL1310110012#
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000269
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110012#_2d1c75ff_c26a_41de_bd0e_21676bd43f58
name: ADSL
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:158
boundary condition: true
initial amount: NaN
is: P30566
constant: false

metaM dolmanp U r
constant: false
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:15809
boundary condition: false
has only substance units: false
is: SBO:0000247
name: Dolichyl phosphate D-mannose, human uterine homolog

metaM ksi deg41 l
notes: FORMULA: C34H58N2O26 CHARGE: 0
boundary condition: false
initial amount: NaN
is: HMDB00143
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
name: keratan sulfate I, degradation product 41
is: CHEBI:12936
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_166a5666_e8fd_4b12_bad0_eb92c472fbb2
is encoded by: hsa:6820
has only substance units: false
boundary condition: true
initial concentration: NaN
name: SULT2B1
is: SBO:0000252
constant: false
type: Species
initial amount: NaN

metaM g1p c
is: CHEBI:58601
is: HMDB01586
name: D-Glucose 1-phosphate
constant: false
is: C00103
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
has only substance units: false
boundary condition: false

metaR FAOXC5C3x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C3)m
type: Reaction

metaR biomass reaction
name: biomass_reaction
reversible: false
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000134

metaR GLCt4
product: MODEL1310110012#
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
name: glucose transport via sodium symport
is: SBO:0000185
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
type: Reaction
reactant: MODEL1310110012#
is described by: ECO:0000269
reversible: true
fast: false

metaM dmpp x
type: Species
constant: false
is: HMDB01120
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
boundary condition: false
is: CHEBI:57623
initial amount: NaN
name: prenyl diphosphate(3-)
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM acgbgbside hs l
is: SBO:0000247
is: CHEBI:17411
constant: false
initial concentration: 1.0
is: HMDB00215
name: beta GalNAc globoside
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false

metaR FAOXC225x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)x
type: Reaction

metaM btcoa x
notes: FORMULA: C25H38N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
is: HMDB01088
constant: false
initial concentration: 1.0
name: Butanoyl-CoA
initial amount: NaN
boundary condition: false
type: Species
is: C00136

http://identifiers.org/biomodels.db/MODEL1310110012#_e25c075d_625b_462b_a4fb_dc5fa2e4d4f6
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:LOC728997
initial concentration: NaN
name: _LOC728997_1_c
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110012#_5ac4c30e_806e_4868_b243_5617631b5145
is encoded by: hsa:4708
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: H7C5B8
name: NDUFB2

metaR NH4t3r
product: MODEL1310110012#
reversible: true
type: Reaction
fast: false
name: ammonia transport via proton antiport
is: SBO:0000185
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110012#
modifier: MODEL1310110012#

metaM Sfglutth c
is: CHEBI:57688
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: HMDB01550
name: S-formylglutathionate(1-)
is: SBO:0000247

metaM HC02175 e
type: Species
is: CHEBI:27689
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
name: caprate
initial concentration: 1.0
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
constant: false

metaR NACHEX8ly
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110012#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction

metaR NaKt
fast: false
is: SBO:0000185
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)
name: Na+/K+ exchanging ATPase
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.6.3.9
reversible: false
modifier: MODEL1310110012#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110012#

metaM strch2 e
is: SBO:0000247
is: HMDB00122
type: Species
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C18H32O16 CHARGE: 0
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
is: CHEBI:4167

metaM tettet6coa x
is: http://identifiers.org/pubchem.compound/47205481
constant: false
name: tetracosatetraenoyl coenzyme A
boundary condition: false
type: Species
is: HMDB06516
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
is: SBO:0000247
is: C16171
has only substance units: false

metaM c16dc c
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00712
initial amount: NaN
constant: false
notes: FORMULA: C23H42NO6 CHARGE: -1
name: Hexadecanedioic acid mono-L-carnitine ester
has only substance units: false

metaM 44mzym r
is: HMDB01286
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
name: 14-demethyllanosterol
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
has only substance units: false
is: CHEBI:18364
initial amount: NaN
constant: false

metaR RE2649C
fast: false
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000000
name: RE2649
kinetic law: MODEL1310110012#

metaM lnlc c
type: Species
constant: false
is: CHEBI:30245
boundary condition: false
is: HMDB00673
name: linoleate
has only substance units: false
initial amount: NaN
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: SBO:0000247
initial concentration: 1.0

metaR r0998
reactant: MODEL1310110012#
type: Reaction
name: Facilitated diffusion
is described by: ECO:0000000
product: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is: SBO:0000185

metaM hs deg12 l
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
boundary condition: false
constant: false
is: HMDB06210
has only substance units: false
name: heparan sulfate, degradation product 12

http://identifiers.org/biomodels.db/MODEL1310110012#_8042d972_856a_4f35_ad88_af85e1087a30
name: _AI769281_1_e
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI769281
has only substance units: false

metaR PCLAD
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (130013.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.1.1.45 Confidence Level: 4 AUTHORS: PMID:12140278 NOTES:NCD
product: MODEL1310110012#
reversible: false
reactant: MODEL1310110012#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110012#
fast: false
name: picolinic acid decarboxylase
is version of: http://identifiers.org/ec-code/4.1.1.45

metaM thmpp c
constant: false
is: SBO:0000247
boundary condition: false
is: C00068
initial concentration: 1.0
type: Species
name: Thiamine diphosphate
initial amount: NaN
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
has only substance units: false
is: CHEBI:45931
is: HMDB01372

metaM galside hs g
boundary condition: false
is: SBO:0000247
type: Species
constant: false
name: D-galactosyl-N-acylsphingosine
initial amount: NaN
initial concentration: 1.0
is: CHEBI:12947
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
has only substance units: false

metaM gal14acglcgalgluside hs g
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
is: SBO:0000247
name: Lactoneotetraosylceramide
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:17103

metaR DOPASULT
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.1
is described by: ECO:0000269
name: Dopamine Sulfotransferase
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)
modifier: MODEL1310110012#

metaR ANTHte
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
product: MODEL1310110012#
is described by: ECO:0000134
fast: false
reversible: true
reactant: MODEL1310110012#
type: Reaction
name: Transport of anthranilate

metaR GLAl
name: galactosidase, alpha
reversible: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.22
kinetic law: MODEL1310110012#
fast: false
product: MODEL1310110012#
is: SBO:0000176
reactant: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (2717.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.22 Confidence Level: 4 AUTHORS: PMID:11775551,PMID:11828341,PMID:15003450,PMID:2836863 NOTES:NJ

metaR 5ADTSTSTERONEtr
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is described by: ECO:0000000
name: 5 alpha dihydrotesterone intracellular transport
type: Reaction
reactant: MODEL1310110012#
is: SBO:0000185
product: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: true

metaM pi n
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN
is: CHEBI:43474
has only substance units: false
constant: false
initial concentration: 1.0
name: hydrogenphosphate
is: HMDB00973

http://identifiers.org/biomodels.db/MODEL1310110012#_cde1e101_be3b_4a1f_8456_9d87bb0c5df3
is: P55809
is encoded by: hsa:5019
boundary condition: true
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: OXCT1
initial concentration: NaN

metaR r0365
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.72
modifier: MODEL1310110012#
is: SBO:0000176
type: Reaction
reversible: false
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
fast: false
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_33ba7739_6aa0_4c05_81e3_29c151880ca2
constant: false
type: Species
initial amount: NaN
name: PIK3CA:PIK3R1
is: SBO:0000297
boundary condition: true
has only substance units: false
is encoded by: hsa:5295
has part: P27986
initial concentration: NaN

metaM c16dc e
name: Hexadecanedioic acid mono-L-carnitine ester
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00712
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C23H42NO6 CHARGE: -1

metaR DAGK hs
is described by: ECO:0000269
name: Diacylglycerol phosphate kinase (homo sapiens)
is version of: http://identifiers.org/ec-code/2.7.1.107
fast: false
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
product: MODEL1310110012#
reversible: true
type: Reaction
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#

metaR DLNLCGCRNt
reversible: false
product: MODEL1310110012#
name: transport into the mitochondria (carnitine)
is: SBO:0000185
modifier: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is described by: ECO:0000000

metaM pi m
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
initial concentration: 1.0
type: Species
name: hydrogenphosphate
is: C00009
is: HMDB00973
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_2b8dd81c_dce1_4364_bfa8_e7c35e3fde9b
type: Species
is: SBO:0000252
boundary condition: true
name: HLCS
initial amount: NaN
has only substance units: false
is encoded by: hsa:3141
initial concentration: NaN
constant: false
is: P50747

http://identifiers.org/biomodels.db/MODEL1310110012#_9c134d0a_6b0a_4f39_8822_522100e25081
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:1119
initial amount: NaN
is: SBO:0000252
constant: false
name: CHKA

metaR SPODMm
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.15.1.1
fast: false
name: superoxide dismutase
modifier: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
reversible: false
is described by: ECO:0000304
kinetic law: MODEL1310110012#

metaR C2tcx
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of acetylcarnitine from peroxisomes to cytosol
type: Reaction

metaM ksi deg30 l
constant: false
initial amount: NaN
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
name: keratan sulfate I, degradation product 30
has only substance units: false
is: HMDB00143
initial concentration: 1.0
is: CHEBI:12936
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_5b462889_347a_40d9_a6f6_ded440153606
constant: false
type: Species
is: P51648
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:224
name: ALDH3A2
has only substance units: false
initial amount: NaN
boundary condition: true

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

metaM ksii core4 pre2 g
initial concentration: 1.0
boundary condition: false
name: keratan sulfate II boisynthesis, precursor 2
is: CHEBI:58053
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C47H76N4O33X CHARGE: -1
is: HMDB00175
constant: false
type: Species
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110012#_d2aeccc0_52b0_454d_9c33_8139b2034967
has only substance units: false
name: PRDX1
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:5052
initial concentration: NaN

metaM prostge1 e
boundary condition: false
has only substance units: false
constant: false
type: Species
name: prostaglandin E1(1-)
is: SBO:0000247
is: CHEBI:57397
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
initial amount: NaN
initial concentration: 1.0
is: HMDB01442

metaR 5ADTSTSTERONESULT
reactant: MODEL1310110012#
modifier: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
is: SBO:0000176
product: MODEL1310110012#
reversible: false
notes: GENE_ASSOCIATION: (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.8.2.14
type: Reaction
name: 5alpha-Dihydrotestosterone sulfotransferase
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110012#_454f49cd_0608_414d_aa58_b5fe95f8a672
type: Species
is: P32322
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: PYCR1
is: SBO:0000252
is encoded by: hsa:5831
constant: false
boundary condition: true

metaR FUMm
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
name: fumarase, mitochondrial
reversible: true
product: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/4.2.1.2
is: SBO:0000176
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110012#
fast: false

metaR AKR1D
is described by: ECO:0000269
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000176
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.3.1.3
reversible: false
fast: false
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
type: Reaction

metaR NRVNCt
name: fatty acid transport via diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#

metaR BPNT
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.7
name: 3',5'-bisphosphate nucleotidase
fast: false
is: SBO:0000176
product: MODEL1310110012#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
modifier: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_61df07fa_74b6_4066_b54d_11f807187fe7
initial amount: NaN
boundary condition: true
name: LRAT
has only substance units: false
constant: false
is: SBO:0000252
is: O95237
type: Species
is encoded by: hsa:9227
initial concentration: NaN

metaR 3HLYTCL
product: MODEL1310110012#
is described by: ECO:0000269
fast: false
name: 3-Hydroxy-L-tyrosine carboxy-lyase
modifier: MODEL1310110012#
reversible: false
type: Reaction
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: NOTES:SAB
is version of: http://identifiers.org/ec-code/4.1.1.28

metaR HSAT1ly
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
name: heparan-glucosaminide N-acetyltransferase, lysosomal
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false
is: SBO:0000185
product: MODEL1310110012#

metaR PPCOAOm
product: MODEL1310110012#
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
is described by: ECO:0000269
modifier: MODEL1310110012#
reversible: false
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
reactant: MODEL1310110012#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110012#_eb35eaeb_397f_4a04_b83b_19860efb99a6
is encoded by: hsa:84532
constant: false
name: ACSS1
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q9NUB1
boundary condition: true
is: SBO:0000252

metaR NAGAlby
type: Reaction
product: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES:Beta-galactosidase B - no evidence to support this actually happens yet; added by analogy with alpha-galactosidase B (NAGAIy) NJ
kinetic law: MODEL1310110012#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110012#
name: N-acetylgalactosaminidase, beta-
fast: false

metaR MM7Cbg
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.113
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000000
reversible: false
type: Reaction
is: SBO:0000176
fast: false

metaM cala c
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:11892
name: N-carbamoyl-beta-alaninate
constant: false
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
initial concentration: 1.0
is: HMDB00026
boundary condition: false

metaM oagd3 hs c
is: SBO:0000247
boundary condition: false
is: HMDB00286
is: C00029
initial amount: NaN
constant: false
name: 9-O-Acetylated GD3
has only substance units: false
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
type: Species
initial concentration: 1.0
is: CHEBI:58367

metaR SFCYSe
reactant: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 2621485 NOTES:sulfocysteine is exfreted in urine
type: Reaction
is: SBO:0000185
name: Exit of sulfocysteine into extra-cellular space
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#

metaM 3tetd7ecoa c
boundary condition: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
is: SBO:0000247
is: HMDB05066
type: Species
name: 3-hydroxy tetradecenoyl-7-coa
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM m4mpdol U r
is: CHEBI:37633
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
constant: false
boundary condition: false
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1

metaM g2m8mpdol U r
is: CHEBI:59093
notes: FORMULA: C1845H3040N20O720P20 CHARGE: -20
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
has only substance units: false
constant: false

metaR LCAT1e
reactant: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3931.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.43 Confidence Level: 4 AUTHORS: PMID:11435418,PMID:11966470 NOTES:NJ
modifier: MODEL1310110012#
reversible: false
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.43
product: MODEL1310110012#
fast: false
name: Lecithin-cholesterol acyltransferase

metaM c6crn c
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: hexanoyl carnitine
notes: FORMULA: C13H25NO4 CHARGE: 0
is: HMDB00705
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_dc30611f_77e5_459c_bad1_20eaf8357801
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4700
is: P56556
initial amount: NaN
type: Species
name: NDUFA6
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_68a98659_52a1_4870_b89e_70f0a455cf95
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:23236
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
name: PLCB1

metaR MI1PP
is described by: ECO:0000269
fast: false
name: myo-inositol 1-phosphatase
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.25
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_78963a0a_5e4f_4855_b358_e64948742fd4
name: NIT2
is: Q9NQR4
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:56954
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true

metaM c51crn c
is: HMDB02366
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: tiglyl carnitine
constant: false
initial amount: NaN
notes: FORMULA: C12H21NO4 CHARGE: 0

metaM hxan c
constant: false
is: C00262
type: Species
is: HMDB00157
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
initial concentration: 1.0
name: Hypoxanthine
boundary condition: false
is: CHEBI:17368
has only substance units: false

metaM retinal 11 cis c
is: SBO:0000247
constant: false
name: 11-cis-retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:16066
initial amount: NaN
type: Species
is: HMDB02152

metaM ksi pre6 g
has only substance units: false
type: Species
boundary condition: false
constant: false
name: keratan sulfate I biosynthesis, precursor 6
is: C00130
notes: FORMULA: C107H174N7O80SX CHARGE: -2
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00175
is: CHEBI:58053

metaR r1671
kinetic law: MODEL1310110012#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
name: Y+LAT2 Utilized transport
reversible: true
modifier: MODEL1310110012#
is: SBO:0000185

metaM dad 2 c
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00101
is: SBO:0000247
initial amount: NaN
is: CHEBI:17256
type: Species
name: 2-deoxyadenosine

metaR EX CE2917 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: apelin-13 exchange
type: Reaction

metaR DESAT24 1
modifier: MODEL1310110012#
is described by: ECO:0000269
type: Reaction
name: fatty acyl-CoA desaturase (n-C24:5CoA -> n-C24:6CoA)
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reversible: false
reactant: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000176
kinetic law: MODEL1310110012#
fast: false

metaM CE0785 m
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
type: Species
name: cis,cis-myristo-5,8-dienoyl-CoA
initial concentration: 1.0
boundary condition: false
is: CHEBI:57795

metaM galside hs c
initial amount: NaN
has only substance units: false
name: D-galactosyl-N-acylsphingosine
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
boundary condition: false
is: CHEBI:12947

metaR FRDPtc
product: MODEL1310110012#
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
name: lipid, flip-flop intracellular transport

metaR KHK3
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.3 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
product: MODEL1310110012#
type: Reaction
name: ketohexokinase (D-tagatose)
is: SBO:0000176
is described by: ECO:0000269
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.3

metaR GLNALANaEx
product: MODEL1310110012#
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
kinetic law: MODEL1310110012#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110012#
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)
reactant: MODEL1310110012#
is: SBO:0000185

metaR FAOXC121C101m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:1-->C10:1)m
type: Reaction

metaR r1670
reversible: true
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110012#
fast: false
type: Reaction
name: Y+LAT2 Utilized transport

metaR THP2Ctp
is: SBO:0000185
kinetic law: MODEL1310110012#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110012#
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
fast: false
type: Reaction
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110012#_ed8209c8_4067_4303_b314_5a3065da870d
has only substance units: false
name: NOS3
initial concentration: NaN
is encoded by: hsa:4846
is: A0S0A7
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
boundary condition: true

metaR PHEMEt
product: MODEL1310110012#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
reversible: false
name: heme transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110012#_10902d45_2582_422f_889e_ab1c13b06e1c
boundary condition: true
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:1215
initial amount: NaN
is: Q4FEB3
initial concentration: NaN
name: CMA1

metaR r0149
is described by: ECO:0000000
fast: false
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.14.13.39
type: Reaction
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110012#
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_778c04bd_5cb0_4090_9304_03fa8257b68b
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q01581
constant: false
name: HMGCS1
is encoded by: hsa:3157
has only substance units: false
initial amount: NaN

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaM n2m2nmn l
type: Species
is: http://identifiers.org/pubchem.compound/3324
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
initial concentration: 1.0
boundary condition: false
is: HMDB00243
initial amount: NaN
notes: FORMULA: C50H84N4O36 CHARGE: 0
is: CHEBI:15361
is: C00022
has only substance units: false
is: SBO:0000247
constant: false

metaR KHK2
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.3 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.3
product: MODEL1310110012#
modifier: MODEL1310110012#
fast: false
is described by: ECO:0000269
name: ketohexokinase (D-xylulose)
reversible: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#

metaR TRPt4
fast: false
name: L-tryptophan transport in via sodium symport
modifier: MODEL1310110012#
is: SBO:0000185
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
reversible: false
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
type: Reaction
is described by: ECO:0000304

metaM 5hoxindoa c
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C10H8NO3 CHARGE: -1 INCHI: InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14) HEPATONET_1.0_ABBREVIATION: HC01537 EHMN_ABBREVIATION: C05635
is: SBO:0000247
is: HMDB00763
name: 5-Hydroxyindoleacetate
is: CHEBI:27823
has only substance units: false

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_4990359b_a5f9_4494_af82_ccc4e4fb23fe
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:248
boundary condition: true
type: Species
initial amount: NaN
constant: false
name: ALPI
is: P09923

http://identifiers.org/biomodels.db/MODEL1310110012#_2bad5d8f_7006_4d05_964a_f94574e72971
name: SLC4A5
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:57835
initial amount: NaN

metaM c51crn e
notes: FORMULA: C12H21NO4 CHARGE: 0
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB02366
name: tiglyl carnitine

metaM hxan e
is: CHEBI:17368
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00157
name: hypoxanthine
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
type: Species
has only substance units: false
is: SBO:0000247

metaR THMMPt4
reversible: true
product: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (6573.1) or (6573.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10542220,PMID:14770311 NOTES:IT
name: Thiamine monophosphate transport in via anion antiport

metaR RTOTAL3FATPc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal3 by enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_4fe96584_7054_469d_9be0_6de0b283d1f7
constant: false
name: SLC16A3
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
is: O15427
has only substance units: false
is encoded by: hsa:9123
initial concentration: NaN

metaR SPMS
kinetic law: MODEL1310110012#
reversible: false
modifier: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6723.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.16 Confidence Level: 4 AUTHORS: PMID:2069720,PMID:8343131 NOTES:
is: SBO:0000176
reactant: MODEL1310110012#
name: spermidine synthase
is version of: http://identifiers.org/ec-code/2.5.1.16

metaR CYSALANaEx
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110012#
is: SBO:0000185
name: L-alanine/L-cysteine Na-dependent exchange (Cys-L in)
reversible: false
reactant: MODEL1310110012#
modifier: MODEL1310110012#

metaR HPDCACRNt
product: MODEL1310110012#
modifier: MODEL1310110012#
reversible: false
name: heptadecanoate transport into the mitochondria
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
reactant: MODEL1310110012#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110012#

metaR FADtru
reactant: MODEL1310110012#
product: MODEL1310110012#
name: FAD transporter, endoplasmic reticulum
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110012#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_ed37b2da_eeb4_40c1_a589_af6c42bba915
type: Species
is: Q8NE62
has only substance units: false
is encoded by: hsa:55349
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: CHDH
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_17a6ff3e_e7e8_41ff_8b3e_751933417aad
name: HK1
has only substance units: false
boundary condition: true
is encoded by: hsa:3098
is: P78542
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252

metaM ocdcea e
initial concentration: 1.0
has only substance units: false
is: HMDB00207
name: octadecenoate (n-C18:1)
is: C00712
initial amount: NaN
boundary condition: false
is: CHEBI:0
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C18H33O2 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110012#_844add38_c1ac_4c99_8f67_c812be40e9b1
boundary condition: true
initial amount: NaN
constant: false
name: ZADH2
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q8N4Q0
has only substance units: false
is encoded by: hsa:284273

http://identifiers.org/biomodels.db/MODEL1310110012#_ffa8dbea_5da3_4436_8e33_9d852a5fdee3
has part: Q6FIH7
has only substance units: false
boundary condition: true
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:516
is: SBO:0000297

metaM chol n
is: HMDB00097
is: CHEBI:15354
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
constant: false
name: choline
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial amount: NaN

metaR PCt
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
name: phosphatidylcholine transporter
is version of: http://identifiers.org/ec-code/3.6.3.44
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
fast: false
product: MODEL1310110012#

metaM pail4p hs c
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:58178
initial amount: NaN
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
type: Species

metaR GLCter
is described by: ECO:0000000
name: glucose transport, endoplasmic reticulum
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
kinetic law: MODEL1310110012#
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110012#
fast: false

metaR r1672
reactant: MODEL1310110012#
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110012#
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#

metaR LEUKTRA4t
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
name: leukotriene A4 transport
is: SBO:0000185
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
type: Reaction

metaM pi l
is: HMDB00973
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:43474
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

metaR LTC4CP
type: Reaction
is described by: ECO:0000000
product: MODEL1310110012#
name: Leukotriene C4 carboxypeptidase
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
fast: false
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
reversible: true
is: SBO:0000176

metaM dcsptn1coa x
is: HMDB06513
boundary condition: false
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205483
initial concentration: 1.0
is: C16173
type: Species
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
constant: false

metaR r0295
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
is: SBO:0000176
product: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
name: glycine synthase Nitrogen metabolism EC:2.1.2.10

metaM gly x
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00123
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: CHEBI:15428
boundary condition: false
type: Species
name: glycine
is: SBO:0000247

metaM 3tetd7ecoa m
type: Species
is: HMDB05066
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
name: 3-hydroxy tetradecenoyl-7-coa

metaM omhpal r
notes: FORMULA: C16H30O3 CHARGE: -1
initial amount: NaN
has only substance units: false
name: w-hydroxypalmiticacid
constant: false
initial concentration: 1.0
is: HMDB06294
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_871eb926_cf15_4620_ac57_9ea53371eafd
boundary condition: true
has only substance units: false
is encoded by: hsa:197258
initial amount: NaN
is: Q8N0W3
constant: false
name: FUK
type: Species
initial concentration: NaN
is: SBO:0000252

metaR D LACt2
kinetic law: MODEL1310110012#
is described by: ECO:0000269
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
reversible: true
is: SBO:0000185
name: D-lactate transport via proton symport
modifier: MODEL1310110012#
type: Reaction
fast: false
reactant: MODEL1310110012#

metaM orot5p c
type: Species
has only substance units: false
boundary condition: false
is: HMDB00218
is: CHEBI:57538
is: C01103
constant: false
initial concentration: 1.0
initial amount: NaN
name: Orotidine 5'-phosphate
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_08fac015_bda9_4b19_b3ec_9fa7c791893a
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: VNN3
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is encoded by: hsa:55350

metaR PDX5PO
name: pyridoxine 5'-phosphate oxidase
is described by: ECO:0000269
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.4.3.5
fast: false
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES:NCD
is: SBO:0000176
product: MODEL1310110012#
modifier: MODEL1310110012#
reversible: true
type: Reaction

metaM ksi deg26 l
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58343
has only substance units: false
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
is: SBO:0000247
is: HMDB00061
constant: false
type: Species
boundary condition: false
name: keratan sulfate I, degradation product 26

metaM sphs1p c
boundary condition: false
type: Species
is: HMDB00277
is: SBO:0000247
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
name: sphingosine 1-phosphate(1-)
initial concentration: 1.0
is: CHEBI:60119
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_e88699a3_82d3_4ac7_b1f5_f12ba743b297
boundary condition: true
is encoded by: hsa:2799
is: Q7Z3X3
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: GNS
constant: false
initial concentration: NaN

metaM pi e
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
constant: false
is: HMDB00973
initial concentration: 1.0
is: SBO:0000247
name: hydrogenphosphate
is: CHEBI:43474
type: Species
initial amount: NaN
is: C00009

http://identifiers.org/biomodels.db/MODEL1310110012#_a9bfc764_d689_4a46_b267_aee792aff2b8
type: Species
initial amount: NaN
boundary condition: true
name: PMM1
is: A8K003
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5372

http://identifiers.org/biomodels.db/MODEL1310110012#_621de6ac_dbd5_47d9_ae5c_05dd9281c0bd
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
name: _LOC647190_1_c
is encoded by: hsa:LOC647190
initial concentration: NaN
is: SBO:0000252
constant: false

metaR sink citr LPAREN c RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: citrulline sink
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_98a2b3ee_d0af_44ed_bd9a_3c1e8cbe7867
boundary condition: true
name: ARSB
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P15848
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:411

metaR PEROXx
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ
name: peroxisomal lumped long chain fatty acid oxidation
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: false
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000

metaM tdcrn c
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C21H41NO4 CHARGE: 0
is: HMDB05066
has only substance units: false
constant: false
initial concentration: 1.0
name: myristoyl carnitine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_a9ab6c0b_dd84_4a6b_9ef5_7affc1bfec27
name: GMPPA
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:29926

metaM thf c
has only substance units: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
constant: false
is: HMDB01846
is: CHEBI:57453
boundary condition: false
type: Species
is: C00101
initial amount: NaN
is: SBO:0000247
name: 5,6,7,8-Tetrahydrofolate
initial concentration: 1.0

metaM 35cgmp c
is: CHEBI:57746
has only substance units: false
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
is: HMDB01314
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
type: Species
name: 3',5'-cyclic GMP(1-)

metaR CITL
name: Citrate lyase
product: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
fast: false
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
is described by: ECO:0000000
reactant: MODEL1310110012#
is: SBO:0000176
reversible: false

metaR ACCOALm
kinetic law: MODEL1310110012#
name: acetate-CoA ligase (AMP-forming)
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.17 Confidence Level: 2 AUTHORS: PMID:11150295 NOTES:TDV-mitochondrial version JLR- also acts on propanoate AMF- made reaction to create AMP not ADP and changed EC
reversible: false
modifier: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.1
is: SBO:0000176
reactant: MODEL1310110012#
is described by: ECO:0000304
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_c9c7d135_b4df_4e9f_bd85_ac2af6bb571d
constant: false
boundary condition: true
name: _AI090874_1_c
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI090874
type: Species

metaR PRAGSr
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110012#
name: phosphoribosylglycinamide synthase
modifier: MODEL1310110012#
reversible: true
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.2

metaM 4fumacac c
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
boundary condition: false
initial concentration: 1.0
name: 4-fumarylacetoacetate(2-)
is: HMDB01268
type: Species
constant: false
is: CHEBI:18034
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_aec42f24_0006_4517_baaf_4c72c493cb2a
boundary condition: true
has only substance units: false
constant: false
type: Species
is: P17174
is encoded by: hsa:2805
is: SBO:0000252
name: GOT1
initial concentration: NaN
initial amount: NaN

metaR UDPACGALtl
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
name: udpacgal intracellular transport
product: MODEL1310110012#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
type: Reaction

metaR r2079
kinetic law: MODEL1310110012#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110012#
modifier: MODEL1310110012#
product: MODEL1310110012#
type: Reaction

metaM CE2915 e
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C44H60N7O11 CHARGE: -1 INCHI: InChI=1/C44H61N7O11/c1-5-26(4)37(44(61)62)49-40(57)34-14-10-22-51(34)43(60)31(19-20-35(53)54)46-41(58)36(25(2)3)48-38(55)32(24-27-11-7-6-8-12-27)47-39(56)33-13-9-21-50(33)42(59)30(45)23-28-15-17-29(52)18-16-28/h6-8,11-12,15-18,25-26,30-34,36-37,52H,5,9-10,13-14,19-24,45H2,1-4H3,(H,46,58)(H,47,56)(H,48,55)(H,49,57)(H,53,54)(H,61,62)/p-1/t26-,30-,31+,32+,33-,34+,36-,37-/m1/s1 EHMN_ABBREVIATION: CE2915
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247
constant: false
boundary condition: false
is: C01936
initial amount: NaN
type: Species
name: beta-casomorphin

metaR EX 3mlda LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-Methylimidazoleacetic acid exchange
type: Reaction

metaM adn e
initial amount: NaN
is: CHEBI:16335
is: SBO:0000247
type: Species
is: C00212
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
name: Adenosine
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00050

http://identifiers.org/biomodels.db/MODEL1310110012#_b7f5a15a_589e_494d_bcc0_174f9d752b66
type: Species
is: SBO:0000252
boundary condition: true
constant: false
name: PDE9A
is encoded by: hsa:5152
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_c6065eaf_221d_4074_a04c_0ec508ae7070
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:124935
initial concentration: NaN
is: Q8N370
initial amount: NaN
constant: false
name: SLC43A2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_ea96d596_774d_4d1d_9809_28031bc2acda
boundary condition: true
name: SOD1
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:6647
initial concentration: NaN
is: P00441
has only substance units: false
initial amount: NaN

metaR 5HOXINDACTO2OX
is version of: http://identifiers.org/ec-code/1.2.3.1
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.3.1 Confidence Level: 2 AUTHORS: PMID:11306106 NOTES:SAB questionable--balanced, but h2o2 production is based on an obscure comment in entrez
type: Reaction
product: MODEL1310110012#
reversible: false
is described by: ECO:0000304
name: 5-Hydroxyindoleacetaldehyde:oxygen oxidoreductase
fast: false
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000176
reactant: MODEL1310110012#

metaR GLNTHRNaEx
name: L-threonine/L-glutamine Na-dependent exchange (Gln-L in)
product: MODEL1310110012#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
is: SBO:0000185
modifier: MODEL1310110012#
fast: false

metaR r1962
fast: false
is: SBO:0000185
reactant: MODEL1310110012#
type: Reaction
name: Y+LAT2 Utilized transport
product: MODEL1310110012#
reversible: false
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR HMGLm
reversible: false
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
product: MODEL1310110012#
reactant: MODEL1310110012#
name: hydroxymethylglutaryl-CoA lyase
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.1.3.4
fast: false
type: Reaction
kinetic law: MODEL1310110012#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110012#_920518ef_a3c0_478d_ad8d_2d84f35f29e0
constant: false
boundary condition: true
name: ENTPD3
type: Species
is: O75355
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:956

http://identifiers.org/biomodels.db/MODEL1310110012#_5acbc54c_5677_4acf_b737_bbf4703d1a54
is: SBO:0000252
name: NMNAT2
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:23057
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_50632637_d863_4b54_b7ab_def49959a4b8
type: Species
is encoded by: hsa:5152
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
name: PDE9A

metaM cs e deg5 l
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:57737
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
initial amount: NaN
boundary condition: false
notes: FORMULA: C31H47NO35S3 CHARGE: -4
initial concentration: 1.0
constant: false
is: HMDB00868

http://identifiers.org/biomodels.db/MODEL1310110012#_62dd54c3_f5af_4a05_b132_e1afd0621024
constant: false
has only substance units: false
is: P50226
type: Species
is encoded by: hsa:6799
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: SULT1A2

metaR r0145
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110012#
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
reversible: true
is version of: http://identifiers.org/ec-code/1.8.3.1
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
product: MODEL1310110012#
fast: false
is: SBO:0000176
type: Reaction

metaM sphs1p e
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:60119
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
initial amount: NaN
constant: false
initial concentration: 1.0
name: sphingosine 1-phosphate(1-)
is: HMDB00277

metaM pi g
boundary condition: false
constant: false
is: HMDB00973
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:43474
type: Species
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

metaR O2Stx
is: SBO:0000185
name: superoxide anion transport via diffusion (peroxisome)
fast: false
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
kinetic law: MODEL1310110012#
type: Reaction
reversible: true

metaM dad 2 e
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00101
constant: false
initial concentration: 1.0
name: 2-deoxyadenosine
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
is: SBO:0000247
is: CHEBI:17256
has only substance units: false

metaM tdcrn e
is: HMDB05066
boundary condition: false
notes: FORMULA: C21H41NO4 CHARGE: 0
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: myristoyl carnitine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_eae6c5ff_96f3_423a_910c_49d24aff1cc6
initial amount: NaN
is: Q8TD30
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: GPT2
constant: false
is encoded by: hsa:84706
has only substance units: false

metaM chol r
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial amount: NaN
is: CHEBI:15354
name: choline
type: Species
is: HMDB00097

http://identifiers.org/biomodels.db/MODEL1310110012#_4704e4c5_8969_4857_be01_5af9b36e668e
boundary condition: true
initial concentration: NaN
is: P42765
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10449
constant: false
initial amount: NaN
name: ACAA2
type: Species

metaR CYTK2n
kinetic law: MODEL1310110012#
type: Reaction
fast: false
reactant: MODEL1310110012#
modifier: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
name: cytidylate kinase (dCMP),nuclear
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true

metaR HSD11B1r
is version of: http://identifiers.org/ec-code/1.1.1.146
fast: false
name: 11-beta-hydroxysteroid dehydrogenase type 1
modifier: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3290.2) or (3290.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.146 Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
type: Reaction
is: SBO:0000176
product: MODEL1310110012#

metaR FAOXC1811602m
type: Reaction
fast: false
kinetic law: MODEL1310110012#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
product: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110012#_44abcc37_abcb_499d_8e9e_ca55b3896f60
has only substance units: false
constant: false
type: Species
is: Q5JRA6
boundary condition: true
is: SBO:0000252
name: MIA3
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:375056

metaR ATP1ter
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110012#
name: ADP/ATP transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110012#_73f503d9_3d04_4b9e_b9b9_ed09b4a32569
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:79053
is: SBO:0000252
name: ALG8
constant: false
has only substance units: false
is: Q9BVK2
boundary condition: true
type: Species

metaR DNDPt34m
reversible: false
product: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110012#
name: dGDP transport via dTDP antiport
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false

metaM ksi pre2 g
is: C00130
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C87H142N6O62X CHARGE: -1
name: keratan sulfate I biosynthesis, precursor 2
is: HMDB00175
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110012#_a2e988fa_e38b_44b9_94c8_1cb87c1d974f
name: _AI285872_1_c
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:AI285872
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM dcyt n
is: CHEBI:15698
name: 2'-deoxycytidine
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
type: Species
initial amount: NaN
is: HMDB00014
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_f3b4cde3_bd02_4f72_8ef1_2ea932b4088e
constant: false
initial concentration: NaN
boundary condition: true
name: _AA664770_1_m
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:AA664770
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_d2f82c76_0f85_4902_8e76_8420d6dff5b8
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
name: PIGG
is: SBO:0000252
is encoded by: hsa:54872
type: Species
is: Q8NCI4

http://identifiers.org/biomodels.db/MODEL1310110012#_metaR_EX_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1 exchange
type: Reaction

metaR 3AIBtm
name: 3-amino-isobutyrate transport, mitochondrial
modifier: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
fast: false
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.6.1.19
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_5e325e73_1c4b_4ab4_9ff9_691cdd8d2785
type: Species
name: CHAT
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is: Q6LEN5
initial concentration: NaN
is encoded by: hsa:1103

metaR GHMT2r
reversible: true
fast: false
reactant: MODEL1310110012#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.1.2.1
kinetic law: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
product: MODEL1310110012#
name: glycine hydroxymethyltransferase, reversible

http://identifiers.org/biomodels.db/MODEL1310110012#_dd4b0e4f_f94c_47e8_b724_11aea3651d82
constant: false
type: Species
has only substance units: false
is encoded by: hsa:4725
initial amount: NaN
name: NDUFS5
is: Q6IBA0
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR MGSA2
product: MODEL1310110012#
name: methyglyoxylate synthase 2 (from g3p)
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:this rxn also represents the enzymatic conversion or non-enzymatic fragmentation of g3p to mthgxl - NCD
type: Reaction
reversible: false
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_42b914c1_ec2d_4725_bc71_1af8285a2943
boundary condition: true
name: _U52111_1_c
initial concentration: NaN
has only substance units: false
is encoded by: hsa:U52111
constant: false
is: SBO:0000252
type: Species
initial amount: NaN

metaR S6T9g
modifier: MODEL1310110012#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110012#
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110012#
reversible: false

metaR EX sfcys LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for sulfocysteine
type: Reaction

metaR C226COAtx
reactant: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
type: Reaction
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000185
name: fatty acid intracellular transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110012#_93065f82_a1ca_434d_95bf_69296bec2d26
is encoded by: hsa:65263
boundary condition: true
name: PYCRL
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is: Q53H96
constant: false

metaR NADPHtxu
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ free hydrogens NJ
reversible: false
product: MODEL1310110012#
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110012#
is described by: ECO:0000000
reactant: MODEL1310110012#
name: NADPH transporter, peroxisome

metaM 3hexdcoa c
is: C05258
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
name: 3-hydroxyhexadecanoylcoa
boundary condition: false
is: HMDB03932
is: SBO:0000247
type: Species

metaR CHOLATEt
is described by: ECO:0000269
product: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
name: cholate transport via bicarbonate countertransport
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ

metaR RE0936E
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.4.17.23
type: Reaction
is: SBO:0000176
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (59272.1) SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 0 AUTHORS: PMID:10969042,PMID:11815627 NOTES:
name: RE0936
is described by: ECO:0000000
reversible: true
fast: false

metaR FAOXC226m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

metaR LEULEUPEPT1tc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_f22bfc8a_91cc_46a6_8934_20aa8fbe5fac
has only substance units: false
is: O95045
is encoded by: hsa:151531
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: UPP2
boundary condition: true
type: Species
constant: false

metaM paps g
is: HMDB01134
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:58339
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053

metaM pi c
is: C00009
type: Species
initial concentration: 1.0
is: HMDB00973
is: CHEBI:43474
notes: FORMULA: HO4P CHARGE: -2
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
name: hydrogenphosphate

http://identifiers.org/biomodels.db/MODEL1310110012#_ad827a08_1b52_483a_a840_32282beb0fd4
is encoded by: hsa:R14373
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
constant: false
name: _R14373_1_x
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_b7c43d5c_c961_4e34_a3f6_5c2d46dab0bb
name: GART
is encoded by: hsa:2618
constant: false
initial concentration: NaN
is: P22102
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species

metaR EX elaid LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: elaidic acid exchange
type: Reaction

metaR r0791
type: Reaction
product: MODEL1310110012#
is described by: ECO:0000000
modifier: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110012#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110012#_f902febc_8841_4c54_a7df_5f8a4ccc18d0
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:8875
is encoded by: hsa:55350
initial concentration: NaN
has part: O95498
has only substance units: false
name: VNN3:VNN2:VNN1
is: SBO:0000297
boundary condition: true

metaR GLUTCOAACBP
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of glutaryl-CoA(5-) from mitochondria into cytosol
type: Reaction

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_08acf9be_900f_45f5_8335_1a41a4dc59dd
has only substance units: false
boundary condition: true
is encoded by: hsa:6489
initial concentration: NaN
is: Q92185
initial amount: NaN
constant: false
is: SBO:0000252
name: ST8SIA1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_dfcd112a_bb54_4b0d_a100_a2ea0e5fa1d9
initial amount: NaN
name: _C7orf24_1_m
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:C7orf24
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_99086563_2f1d_4788_8a9c_f64e56e00914
name: PDE4D
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q08499
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:5144

metaR FAOXC221C201x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

metaM chol g
initial amount: NaN
is: HMDB00097
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
constant: false
name: choline
initial concentration: 1.0
is: CHEBI:15354

metaR r1421
fast: false
is described by: ECO:0000000
name: Free diffusion
is: SBO:0000185
product: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: true

metaM xtsn c
constant: false
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
boundary condition: false
is: CHEBI:18107
is: HMDB00299
name: xanthosine
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaR r1966
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110012#
fast: false
modifier: MODEL1310110012#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110012#
name: Y+LAT2 Utilized transport
product: MODEL1310110012#

metaR r0792
is: SBO:0000176
type: Reaction
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
reversible: true
fast: false
reactant: MODEL1310110012#
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/4.2.1.107

http://identifiers.org/biomodels.db/MODEL1310110012#_7dff1ec9_02a2_4dec_bccd_15b324b433c5
constant: false
has only substance units: false
is: E9PB82
name: HSD17B4
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3295
type: Species
boundary condition: true

metaM 3octdeccrn c
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: 3-hydroxyoctadecanoyl carnitine
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB13336
notes: FORMULA: C25H49NO5 CHARGE: 0

metaR CYSSNAT5tc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM aicar c
type: Species
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
is: CHEBI:58475
is: HMDB01517
initial concentration: 1.0
is: C04677
constant: false
initial amount: NaN
boundary condition: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
has only substance units: false
is: SBO:0000247

metaR SERDGLYexR
product: MODEL1310110012#
is: SBO:0000185
fast: false
modifier: MODEL1310110012#
reactant: MODEL1310110012#
name: D-Serine/Glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110012#
is described by: ECO:0000304
reversible: true
type: Reaction

metaR r0142
is described by: ECO:0000000
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
modifier: MODEL1310110012#
product: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
reactant: MODEL1310110012#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110012#_6b24e97f_d924_461d_b602_c9ed952438f5
type: Species
initial concentration: NaN
name: COX2
is encoded by: hsa:4513
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q7GXZ8

http://identifiers.org/biomodels.db/MODEL1310110012#_e39e51f1_4498_4b49_9284_952be2d0e614
name: NT5C2
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:22978
constant: false
is: P49902
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_17b30e3e_f778_47f7_900c_6da6aba161c5
has only substance units: false
initial amount: NaN
name: SLC25A26
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:115286
type: Species

metaM ksii core4 deg4 l
notes: FORMULA: C66H108N6O48SX CHARGE: -1
boundary condition: false
is: CHEBI:16953
name: keratan sulfate II (core 4-linked), degradation product 4
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00812
initial concentration: 1.0
type: Species

metaM glyclt c
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
has only substance units: false
name: glycolate
constant: false
is: SBO:0000247
is: HMDB00115
initial concentration: 1.0
initial amount: NaN
is: CHEBI:29805
type: Species
boundary condition: false

metaM thf e
initial concentration: 1.0
type: Species
is: CHEBI:57453
is: SBO:0000247
boundary condition: false
has only substance units: false
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
is: HMDB01846
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
constant: false
initial amount: NaN

metaR S6TASE18ly
is described by: ECO:0000000
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110012#
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
fast: false
reactant: MODEL1310110012#
type: Reaction

metaR NAt5
fast: false
modifier: MODEL1310110012#
product: MODEL1310110012#
name: sodium/ammonium proton antiporter
notes: GENE_ASSOCIATION: (6548.1) or (6550.1) or (6549.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:8199403,PMID:8595899 NOTES:NCD
kinetic law: MODEL1310110012#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110012#

metaR 3AIBTm
modifier: MODEL1310110012#
name: L-3-aminoisobutyrate transaminase, mitochondrial
product: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.19
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
is: SBO:0000176
is described by: ECO:0000304
type: Reaction

metaR GULN3D
is: SBO:0000176
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
type: Reaction
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
is described by: ECO:0000000
reversible: true
name: L-gulonate 3-dehydrogenase

http://identifiers.org/biomodels.db/MODEL1310110012#_112dcccf_37d3_48ae_b963_fb5f9f8075c6
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:6783
constant: false
is: SBO:0000252
name: SULT1E1
boundary condition: true
is: P49888
initial concentration: NaN

metaR DOLGLCP Uter
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110012#
is described by: ECO:0000000
reversible: false
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)
kinetic law: MODEL1310110012#
type: Reaction
product: MODEL1310110012#

metaR O2Stn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
type: Reaction
name: superoxide anion transport via diffusion (nucleus)
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110012#
is described by: ECO:0000000
kinetic law: MODEL1310110012#
product: MODEL1310110012#

metaR OCBTm
reversible: false
fast: false
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
name: ornithine carbamoyltransferase, irreversible
reactant: MODEL1310110012#
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.1.3.3
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5009.1) SUBSYSTEM: Urea cycle EC Number: 2.1.3.3 Confidence Level: 4 AUTHORS: PMID:12538786,PMID:6372096 NOTES:TDV

http://identifiers.org/biomodels.db/MODEL1310110012#_3933ef94_317d_4c29_87fc_ae6be85cbf55
has only substance units: false
name: GLS2
is: SBO:0000252
is encoded by: hsa:27165
boundary condition: true
initial concentration: NaN
type: Species
constant: false
initial amount: NaN

metaM chol m
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
name: choline
is: CHEBI:15354
is: HMDB00097
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114

http://identifiers.org/biomodels.db/MODEL1310110012#_da153cc0_9803_4680_8930_842153bba3d0
has only substance units: false
type: Species
name: CYP2C9
initial concentration: NaN
constant: false
boundary condition: true
is: P11712
is: SBO:0000252
is encoded by: hsa:1559
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_3d3b8eff_319c_45f8_8511_e8e20ab3a2f6
initial concentration: NaN
constant: false
type: Species
boundary condition: true
initial amount: NaN
name: GCK
is: Q53Y25
has only substance units: false
is encoded by: hsa:2645
is: SBO:0000252

metaR r0579
is version of: http://identifiers.org/ec-code/1.13.11.19
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
kinetic law: MODEL1310110012#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
product: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110012#
is: SBO:0000176
fast: false

metaM srtn e
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:350546
name: serotonin(1+)
type: Species
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
boundary condition: false
constant: false
is: HMDB00259

http://identifiers.org/biomodels.db/MODEL1310110012#_2531e75f_bf24_4005_96ae_6d8e93e04163
has only substance units: false
type: Species
has part: P51553
boundary condition: true
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:3421
has part: O43837
is encoded by: hsa:3420
name: IDH3A:IDH3B:IDH3G
constant: false
initial concentration: NaN

metaR HDCEAtr
reversible: true
product: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
name: fatty acid transport via diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110012#

metaR PDHm
type: Reaction
name: pyruvate dehydrogenase
modifier: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (1738.1 and 8050.1) and (5161.1 and 5162.1) and (1737.1) or (1738.1 and 8050.1) and (5160.1 and 5162.1) and (1737.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.3.1.12 Confidence Level: 0 AUTHORS: PMID:12372595,PMID:16436377 NOTES:12372595 - expression; 16436377 - biochemical, tissue-specific
is version of: http://identifiers.org/ec-code/1.2.4.1
kinetic law: MODEL1310110012#
fast: false
reversible: false
is: SBO:0000176
product: MODEL1310110012#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/2.3.1.12

http://identifiers.org/biomodels.db/MODEL1310110012#_e1fdb972_ac59_4767_84ef_964f718fc5cf
is: SBO:0000252
is encoded by: hsa:28
boundary condition: true
has only substance units: false
constant: false
is: P16442
type: Species
initial amount: NaN
initial concentration: NaN
name: ABO

http://identifiers.org/biomodels.db/MODEL1310110012#_97720f89_b027_4773_a51d_a8e82b0fc626
name: PKM2
constant: false
is encoded by: hsa:5315
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P14618

metaM 3octdeccrn e
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
type: Species
notes: FORMULA: C25H49NO5 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
name: 3-hydroxyoctadecanoyl carnitine
is: HMDB13336

metaM adn m
boundary condition: false
type: Species
notes: FORMULA: C10H13N5O4 CHARGE: 0 INCHI: InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
name: adenosine
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00050
is: CHEBI:16335

metaM m2mn l
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
is: SBO:0000247
has only substance units: false
type: Species
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
initial amount: NaN
is: HMDB06537
initial concentration: 1.0
boundary condition: false
constant: false

metaR 3HBCOAHLm
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110012#
product: MODEL1310110012#
fast: false
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
reversible: false
reactant: MODEL1310110012#

metaR OCDCEAtr
reactant: MODEL1310110012#
name: fatty acid transport via diffusion
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
product: MODEL1310110012#
is: SBO:0000185
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_f961c650_ca04_4007_97a5_4d52d2273cec
name: _D29675_1_c
is encoded by: hsa:D29675
initial concentration: NaN
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_3849de57_cc92_4c4c_84ae_9dc5f72f1b50
is encoded by: hsa:10050
name: SLC17A4
is: Q9Y2C5
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true

metaM ocdcea c
is: C00712
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00207
type: Species
boundary condition: false
name: octadecenoate (n-C18:1)
notes: FORMULA: C18H33O2 CHARGE: -1
initial concentration: 1.0
is: CHEBI:0

metaM m7mpdol U r
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
constant: false
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1665H2740N20O570P20 CHARGE: -20
initial concentration: 1.0
initial amount: NaN
is: CHEBI:37636

metaR MANtg
product: MODEL1310110012#
is: SBO:0000185
reactant: MODEL1310110012#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: mannose efflux from Golgi apparatus
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_c8505337_f3c6_4a10_bba4_8b31c9d1cad5
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2590
boundary condition: true
initial amount: NaN
name: GALNT2
constant: false
has only substance units: false
type: Species
is: Q10471

metaR DCK1n
product: MODEL1310110012#
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
modifier: MODEL1310110012#
reversible: true
kinetic law: MODEL1310110012#
name: Deoxycytidine kinase, nuclear (ATP)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.74
reactant: MODEL1310110012#

metaR THRALANaEx
type: Reaction
name: L-alanine/L-threonine Na-dependent exchange (Thr-L in)
is: SBO:0000185
product: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110012#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110012#_d0b1934b_8937_40cd_a7e7_d0aa44d1e03f
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6241
name: RRM2
is: P31350
constant: false

metaR GALGLUSIDEtl
is: SBO:0000185
kinetic law: MODEL1310110012#
reversible: true
name: galgluside hs intracellular transport
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
product: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_1f556892_af6f_4eaa_b302_24c91ef526b9
is encoded by: hsa:7296
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false
name: TXNRD1

http://identifiers.org/biomodels.db/MODEL1310110012#_86b0a656_d82f_4258_b8d5_2b4cfb84eb7a
initial amount: NaN
constant: false
is: Q13510
type: Species
has only substance units: false
is encoded by: hsa:427
name: ASAH1
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM dcyt e
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: SBO:0000247
constant: false
is: HMDB00014
name: Deoxycytidine
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:15698
is: C00881
boundary condition: false

metaM btcoa c
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB01088
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:57371
name: Butanoyl-CoA
is: C00136

metaM tym c
is: HMDB00306
is: CHEBI:327995
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: tyraminium
is: SBO:0000247
type: Species
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
has only substance units: false

metaM dece4coa m
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
name: 4-decenoylcoa
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB02145
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_544720d0_8786_40fd_85e8_91676c7ee687
constant: false
name: GPX1
is encoded by: hsa:2876
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is: P07203

http://identifiers.org/biomodels.db/MODEL1310110012#_a189c361_1bac_44f2_ba7e_aecbc845921e
initial amount: NaN
is: Q96NR8
is encoded by: hsa:145226
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial concentration: NaN
name: RDH12

metaM srtn c
is: CHEBI:350546
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: HMDB00259
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: serotonin(1+)

metaR IZPN
type: Reaction
product: MODEL1310110012#
reversible: false
kinetic law: MODEL1310110012#
fast: false
name: Imidazolonepropionase
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reactant: MODEL1310110012#
is described by: ECO:0000000

metaM tettet6coa c
initial amount: NaN
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
is: C16171
is: HMDB06516
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
name: tetracosatetraenoyl coenzyme A
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205481

http://identifiers.org/biomodels.db/MODEL1310110012#_f58daf60_e8d1_4cdd_ab81_3cce6c1c8a83
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:47
boundary condition: true
has only substance units: false
constant: false
type: Species
name: ACLY

metaM ru5p D r
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:58121
name: D-ribulose 5-phosphate(2-)
is: HMDB00618

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

metaM hdd2coa x
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:61526
is: HMDB03945
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
name: (E)-hexadec-2-enoyl-CoA(4-)

metaM hs deg10 l
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00127
is: CHEBI:15748
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
name: heparan sulfate, degradation product 10

http://identifiers.org/biomodels.db/MODEL1310110012#_98de0cbc_12a7_45ec_bafe_46fd9ec871ec
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: ASPA
constant: false
boundary condition: true
initial concentration: NaN
is: Q6FH48
is encoded by: hsa:443

metaR LIMNENte
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, xenobiotic transport (original and metabolized) NJ
name: xenobiotic transport
reversible: true
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_3b387b5a_cdc4_401d_8dd3_1610dfef003e
type: Species
has only substance units: false
is: O00767
name: SCD
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6319
constant: false
boundary condition: true

metaR NACHEX1ly
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
reactant: MODEL1310110012#
product: MODEL1310110012#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false

metaR VALLAT1tc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Valine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

metaR r0578
modifier: MODEL1310110012#
reactant: MODEL1310110012#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
product: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/4.1.2.27
type: Reaction
is described by: ECO:0000000

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaR C80CPT1
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of octanoylcarnitine
type: Reaction

metaR ASCBOX
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: ascorbic acid oxidase
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction

metaR HISCAT1
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaR EICOSTETCPT2
reversible: false
name: carnitine transferase
fast: false
type: Reaction
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
is described by: ECO:0000000

metaR STS1
is version of: http://identifiers.org/ec-code/3.1.6.2
type: Reaction
modifier: MODEL1310110012#
reversible: false
kinetic law: MODEL1310110012#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ
product: MODEL1310110012#
is: SBO:0000176
reactant: MODEL1310110012#
name: Steryl-sulfatase

metaR ARTCOAL3
product: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: R group synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:HR fatty acid metabolism - R groups = acyl groups, Rtotal, Rtotal2, Rtotal3 correspond to three possible acyl groups added to glycerol Carbon stoichiometry normalized wrt C16 R1 - C16 groups R2 - essential FA + associated derivatives R3 - non-essential, dietary FA (C18) R4 - monounsaturated FA R5 -other (C26, C24) NJ
reversible: false
reactant: MODEL1310110012#
is described by: ECO:0000000
type: Reaction
name: R group coenzyme a ligase
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110012#_2254a356_df46_4359_838c_6a36c8b24851
is encoded by: hsa:6392
is encoded by: hsa:6391
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
constant: false
has part: O14521
name: SDHA:SDHB:SDHC:SDHD
is encoded by: hsa:6390
is: SBO:0000297
has part: P21912
has part: P31040
is encoded by: hsa:6389
has part: Q99643

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

metaR HSPASEly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
name: heparan sulfate proteoglycan protease, lysosome (endosome)
fast: false
reversible: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

metaM ksi deg27 l
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
constant: false
is: HMDB00143
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
name: keratan sulfate I, degradation product 27
is: CHEBI:12936

metaR RE2660N
reactant: MODEL1310110012#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.96
type: Reaction
is: SBO:0000176
name: RE2660
is described by: ECO:0000000
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
product: MODEL1310110012#

metaR ALR3
product: MODEL1310110012#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.2
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.1.1.21
reactant: MODEL1310110012#
modifier: MODEL1310110012#
name: aldose reductase (acetol)
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_ffd46cc4_6727_4764_89bc_09e317103937
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5279
has only substance units: false
name: PIGC
initial concentration: NaN
is: Q92535
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_560fdeb5_93b5_4ad3_bdd0_4fc2b31b0a1d
name: NDUFB5
type: Species
boundary condition: true
is encoded by: hsa:4711
is: O43674
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR STS2
product: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ
is described by: ECO:0000269
reactant: MODEL1310110012#
fast: false
reversible: false
is: SBO:0000176
name: Steryl-sulfatase
is version of: http://identifiers.org/ec-code/3.1.6.2
modifier: MODEL1310110012#

metaR HISTAtu
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000269
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
fast: false
reversible: true
name: Histamine uniport
reactant: MODEL1310110012#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_6fc36613_f016_482f_b2c4_38170aa4a9f4
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: Q99714
constant: false
name: HSD17B10
initial concentration: NaN
is encoded by: hsa:3028

http://identifiers.org/biomodels.db/MODEL1310110012#_b61d09bf_e4ac_4100_90e1_060be625b0c8
type: Species
is: SBO:0000252
name: NDUFS2
boundary condition: true
initial amount: NaN
is: B7Z792
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:4720

metaM taur c
is: HMDB00251
type: Species
has only substance units: false
initial concentration: 1.0
is: C00245
is: SBO:0000247
is: CHEBI:3544
notes: FORMULA: C2H7NO3S CHARGE: 0
constant: false
initial amount: NaN
name: Taurine
boundary condition: false

metaR NTP3e
name: nucleoside-triphosphatase (GTP)
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.6
reversible: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
product: MODEL1310110012#

metaM acac c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: HMDB00060
type: Species
boundary condition: false
name: acetoacetate
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:13705

http://identifiers.org/biomodels.db/MODEL1310110012#_a235a1b2_2b31_4379_998a_3b57d930f548
is encoded by: hsa:477
has only substance units: false
initial concentration: NaN
has part: Q9UN42
name: ATP1B4:ATP1A2
is: SBO:0000297
type: Species
has part: P50993
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:23439

metaM ksi deg6 l
constant: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 6
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
initial amount: NaN
is: HMDB00143
is: SBO:0000247
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110012#_466e6a21_e1b5_4c6f_a441_bd94e6bc0f68
initial concentration: NaN
initial amount: NaN
is: Q5QPH3
has only substance units: false
is: SBO:0000252
name: ACSS2
constant: false
boundary condition: true
type: Species
is encoded by: hsa:55902

metaM CE2434 m
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:57795

metaM ksii core4 e
is: SBO:0000247
is: CHEBI:17268
is: HMDB00211
boundary condition: false
constant: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
has only substance units: false
type: Species
initial amount: NaN
name: keratan sulfate II (core 4-linked)
initial concentration: 1.0

metaM CE5236 n
is: HMDB03952
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: SBO:0000247
type: Species
boundary condition: false
constant: false
name: O2'-4a-cyclic-tetrahydrobiopterin
is: CHEBI:28002
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_99fc028a_0cfd_4781_8f89_2a60d784d458
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000297
has part: P38117
initial amount: NaN
type: Species
is encoded by: hsa:2109
name: ETFA:ETFB

metaR GALtly
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
fast: false
is: SBO:0000185
name: galactose efflux from lysosome
reactant: MODEL1310110012#
product: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: false

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaM acnam c
boundary condition: false
is: HMDB00230
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
name: N-acetylneuraminate
is: CHEBI:35418
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_38f67d01_ae89_48cc_acc0_8c1cd8b781d2
type: Species
initial amount: NaN
is: SBO:0000252
name: PLCZ1
constant: false
has only substance units: false
is: Q86YW0
initial concentration: NaN
boundary condition: true
is encoded by: hsa:89869

metaR GLUDxm
is described by: ECO:0000269
product: MODEL1310110012#
name: glutamate dehydrogenase (NAD) (mitochondrial)
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.4.1.3
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
reversible: true
is: SBO:0000176
modifier: MODEL1310110012#
type: Reaction
fast: false

metaM pydxn c
is: HMDB00239
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
is: CHEBI:16709
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: Pyridoxine
is: C00314
constant: false

metaM digalside hs l
is: C06126
has only substance units: false
name: Digalactosylceramide
is: http://identifiers.org/pubchem.compound/8383
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
type: Species
initial concentration: 1.0

metaR r0587
modifier: MODEL1310110012#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110012#
reversible: true
fast: false
reactant: MODEL1310110012#
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
kinetic law: MODEL1310110012#

metaR SBT Dtde
reactant: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
kinetic law: MODEL1310110012#
is described by: ECO:0000134
name: D-sorbitol transport, extracellular
product: MODEL1310110012#
is: SBO:0000185
fast: false
reversible: true

metaR DCSPTN1COAtx
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
kinetic law: MODEL1310110012#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110012#
product: MODEL1310110012#
fast: false
name: fatty acid intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110012#_ab232ff4_d23d_4730_8f9d_e6bd15d0987c
boundary condition: true
name: CMAS
has only substance units: false
is: SBO:0000252
is encoded by: hsa:55907
is: Q8NFW8
initial concentration: NaN
constant: false
type: Species
initial amount: NaN

metaM hdd2coa c
type: Species
initial amount: NaN
is: HMDB03945
is: C05272
has only substance units: false
is: CHEBI:61526
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
name: trans-Hexadec-2-enoyl-CoA
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_07b99f91_b523_449b_a84b_245234f43401
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3421
has only substance units: false
type: Species
is: P51553
name: IDH3G
boundary condition: true

metaM acac e
is: HMDB00060
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
name: acetoacetate
is: CHEBI:13705
has only substance units: false
initial amount: NaN

metaR FAOXC143C123x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)x
type: Reaction

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_5d1a8e04_fafd_4c0e_a88c_3b14f4b54ff0
is: P13196
name: ALAS1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:211
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial amount: NaN

metaM nadph x
is: C00005
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB00221
boundary condition: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: CHEBI:57783

http://identifiers.org/biomodels.db/MODEL1310110012#_b2235440_343e_4491_a1c7_cd222b838782
boundary condition: true
name: ABAT
type: Species
is encoded by: hsa:18
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR C161CRN2t
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
modifier: MODEL1310110012#
is: SBO:0000185
kinetic law: MODEL1310110012#
fast: false
name: C161 transport into the mitochondria
reactant: MODEL1310110012#
product: MODEL1310110012#
reversible: false

metaR S2TASE3ly
modifier: MODEL1310110012#
is: SBO:0000176
name: iduronate-2-sulfatase, lysosomal
reversible: false
product: MODEL1310110012#
type: Reaction
fast: false
reactant: MODEL1310110012#
is described by: ECO:0000000
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.13

metaR UAGDP
name: UDP-N-acetylglucosamine diphosphorylase
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.7.23
type: Reaction
product: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#

metaM dmnoncoa x
constant: false
boundary condition: false
name: 4,8 dimethylnonanoyl-CoA
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
initial amount: NaN
is: HMDB11604
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_metaM_fucgalacglcgal14acglcgalgluside_hs_g
is: SBO:0000247
name: VI2Fuc-nLc6
boundary condition: false
type: Species
notes: FORMULA: C64H112N3O36FULLRCO CHARGE: 0
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:61648
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_b3fec465_f45d_4805_ae3b_e037a2b5a664
is encoded by: hsa:4830
is: SBO:0000252
constant: false
initial concentration: NaN
name: NME1
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false

metaM peamn c
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
name: 2-phenylethanaminium
initial amount: NaN
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
is: HMDB12275
type: Species
is: CHEBI:225237

metaR Q10H2e
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110012#
name: transport of ubiquinol into lymph
kinetic law: MODEL1310110012#
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_9a57233c_5efb_4737_a523_9d79a032fe25
initial amount: NaN
is: SBO:0000252
is: Q96P26
is encoded by: hsa:93034
boundary condition: true
has only substance units: false
type: Species
name: NT5C1B
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_93f6d32a_bc51_4a7b_9eba_1ee58068b089
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: GMDS
is: SBO:0000252
is: O60547
is encoded by: hsa:2762
initial concentration: NaN

metaM hexe3coa x
has only substance units: false
constant: false
boundary condition: false
name: 3-hexenoylcoa
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
is: HMDB06522
is: SBO:0000247
type: Species

metaR DAGt
product: MODEL1310110012#
name: diacylglycerol transport
kinetic law: MODEL1310110012#
is described by: ECO:0000269
reactant: MODEL1310110012#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reversible: true

metaM asn L e
is: HMDB00168
name: L-asparagine
constant: false
is: SBO:0000247
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17196
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_b703262b_b081_4583_b7d2_1a73ae418faa
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
name: SQLE
is: SBO:0000252
boundary condition: true
is: Q5HYI4
has only substance units: false
is encoded by: hsa:6713

http://identifiers.org/biomodels.db/MODEL1310110012#_8fd6ad8c_7b55_433b_a869_8090a3c90f4e
type: Species
has only substance units: false
is encoded by: hsa:60490
constant: false
is: Q96CD2
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: PPCDC

metaM gly e
constant: false
boundary condition: false
name: Glycine
initial amount: NaN
is: C00037
notes: FORMULA: C2H5NO2 CHARGE: 0
has only substance units: false
type: Species
is: HMDB00123
is: SBO:0000247
is: CHEBI:3339
initial concentration: 1.0

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_ed609684_eff8_4ac6_a185_c1757cb1514e
name: PIK3C2G
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: O75747
is encoded by: hsa:5288
is: SBO:0000252
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_da61ce75_1553_4b2c_975d_a0b243dd316e
constant: false
name: PFAS
initial concentration: NaN
initial amount: NaN
is: Q6P4B4
is encoded by: hsa:5198
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false

metaM xol7aone c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
name: 7alpha-hydroxycholest-4-en-3-one
initial amount: NaN
is: CHEBI:17899
boundary condition: false
constant: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: HMDB01993

http://identifiers.org/biomodels.db/MODEL1310110012#_4179766d_f358_4364_ad9b_4f37330114a2
name: SLC7A10:SLC3A2
has only substance units: false
is: SBO:0000297
constant: false
initial amount: NaN
is encoded by: hsa:6520
has part: P08195
initial concentration: NaN
type: Species
is encoded by: hsa:56301
has part: Q9NS82
boundary condition: true

metaM 2mop c
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
is: CHEBI:57700
is: HMDB01172
name: 2-methyl-3-oxopropanoate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
boundary condition: false
initial concentration: 1.0

metaM pdx5p c
type: Species
is: SBO:0000247
is: CHEBI:58589
is: C00627
is: HMDB01319
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C8H10NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00459 EHMN_ABBREVIATION: C00627
boundary condition: false
initial concentration: 1.0
name: Pyridoxine 5'-phosphate

metaM nadh x
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: C00004
name: Nicotinamide adenine dinucleotide - reduced
constant: false
initial concentration: 1.0
is: CHEBI:57945
boundary condition: false
is: HMDB01487
is: http://identifiers.org/pubchem.compound/3306

metaM dectricoa m
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
constant: false
name: 2,4,7-decatrienoylcoa
is: SBO:0000247

metaM c4crn x
boundary condition: false
initial amount: NaN
notes: FORMULA: C11H21NO4 CHARGE: 0
has only substance units: false
is: http://identifiers.org/pubchem.compound/213144
type: Species
is: SBO:0000247
name: butyryl carnitine
initial concentration: 1.0
constant: false
is: HMDB02013
is: C02862

metaM chol c
name: Choline
is: C00114
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: HMDB00097
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: CHEBI:15354
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaM HC02216 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
name: prostaglandin-f2beta
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28922
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_525ad136_d2ca_4d89_af7c_963b5a53d18c
is: SBO:0000252
is: Q8IV97
is encoded by: hsa:8140
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: SLC7A5
constant: false
boundary condition: true
type: Species

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR EX CE1936 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermine dialdehyde exchange
type: Reaction

metaR CYOR u10m
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.5.1.92
fast: false
product: MODEL1310110012#
type: Reaction
is: SBO:0000185
reversible: false
reactant: MODEL1310110012#
name: ubiquinol-6 cytochrome c reductase, Complex III
modifier: MODEL1310110012#

metaR TRPt
name: L-tryptophan transport
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
reversible: true
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110012#_d5b0181c_63cf_4c55_8596_65ecf004f3b4
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: ME3
is encoded by: hsa:10873
is: Q6TCH8
has only substance units: false

metaM o2 c
name: O2
initial concentration: 1.0
is: C00007
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
constant: false
type: Species
is: SBO:0000247
is: HMDB01377
initial amount: NaN
boundary condition: false
has only substance units: false

metaR r0584
product: MODEL1310110012#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
is described by: ECO:0000000
reactant: MODEL1310110012#

metaM HC01397 m
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:27402
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
initial concentration: 1.0
constant: false
name: (S)-3-Hydroxyhexadecanoyl-CoA

metaM gacpail hs r
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:16344
initial concentration: 1.0
name: glucosaminyl-acylphosphatidylinositol
has only substance units: false
is: SBO:0000247
is: HMDB00128

metaM pac c
has only substance units: false
is: HMDB00209
initial concentration: 1.0
constant: false
is: CHEBI:18401
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
is: SBO:0000247
name: phenylacetate
initial amount: NaN
boundary condition: false
type: Species

metaM asn L c
is: SBO:0000247
is: CHEBI:17196
boundary condition: false
name: L-asparagine
initial concentration: 1.0
type: Species
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
has only substance units: false
initial amount: NaN
is: HMDB00168
constant: false

metaR ALASm
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110012#
is described by: ECO:0000254
reversible: false
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.29
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.37
name: 5-aminolevulinate synthase
kinetic law: MODEL1310110012#

metaM chol e
is: HMDB00097
is: SBO:0000247
has only substance units: false
is: CHEBI:15354
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: Choline
type: Species
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: C00114

http://identifiers.org/biomodels.db/MODEL1310110012#_4d347cf0_0a21_4c80_b26f_648c39f95e62
is encoded by: hsa:2954
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: GSTZ1
has only substance units: false
is: SBO:0000252
constant: false
type: Species

metaR ICDHxm
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3421.2 and 3420.3 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.3 and 3421.1 and 3419.1) or (3421.1 and 3419.1 and 3420.2) or (3421.2 and 3419.1 and 3420.2) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.41 Confidence Level: 0 AUTHORS: PMID:10601238,PMID:14555658 NOTES:The reaction may be reversible. Strathern shows the reactions as irreversible. IF. Biochemical, Genetic
name: Isocitrate dehydrogenase (NAD+)
is described by: ECO:0000134
modifier: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.41

metaR HMGCOAtx
is described by: ECO:0000000
kinetic law: MODEL1310110012#
fast: false
product: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
reversible: true

metaR GASNASE3ly
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
name: glycosylasparaginase, lysosomal
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.26
product: MODEL1310110012#

metaR PIK4n
type: Reaction
name: phosphatidylinositol 4-kinase, nuclear
product: MODEL1310110012#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:NJ
is: SBO:0000176
reactant: MODEL1310110012#
is described by: ECO:0000000
kinetic law: MODEL1310110012#

metaR EX gbside hs LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: globoside (homo sapiens) exchange
type: Reaction

metaR TTDCRNt
name: transport into the mitochondria (carnitine)
is described by: ECO:0000000
kinetic law: MODEL1310110012#
is: SBO:0000185
fast: false
reactant: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110012#
product: MODEL1310110012#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110012#_4280a798_3bba_4ebf_a9b6_466082a5aeb1
initial amount: NaN
name: CHST5
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:23563
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_11c55120_06ac_4f9d_94b1_39e5c75fc3d4
initial amount: NaN
boundary condition: true
is encoded by: hsa:5833
initial concentration: NaN
constant: false
is: F5H8B1
is: SBO:0000252
has only substance units: false
name: PCYT2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_79ef69cf_ebd2_40de_a676_370d73dd63d6
constant: false
boundary condition: true
has only substance units: false
name: _AI926493_1_m
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI926493

http://identifiers.org/biomodels.db/MODEL1310110012#_metaR_EX_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIAb exchange
type: Reaction

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM o2 e
name: O2
initial amount: NaN
is: C00007
has only substance units: false
is: SBO:0000247
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB01377
constant: false

metaR PAIL HStn
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
name: phosphatidylinositol nuclear transport (diffusion)
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110012#
is: SBO:0000185

metaM c4crn m
is: HMDB02013
boundary condition: false
is: http://identifiers.org/pubchem.compound/213144
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: C02862
name: butyryl carnitine
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C11H21NO4 CHARGE: 0

metaR MG3er
kinetic law: MODEL1310110012#
reversible: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
reactant: MODEL1310110012#
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_39814a37_d9c0_4a14_b507_e6fd0c54db80
constant: false
is: A8K4A0
initial concentration: NaN
has only substance units: false
name: ARSB
boundary condition: true
is encoded by: hsa:411
is: SBO:0000252
type: Species
initial amount: NaN

metaM CE2418 m
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
is: HMDB11123
is: CHEBI:28387
has only substance units: false
initial amount: NaN
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
constant: false

metaR DOLPGT1 Uer
is version of: http://identifiers.org/ec-code/2.4.1.267
reactant: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#
reversible: false
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
fast: false
type: Reaction
kinetic law: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10359825 NOTES:EC 2.4.1.- NCD
is described by: ECO:0000000

metaR r1668
fast: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110012#
reversible: true
product: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_1088e3d6_712d_4d59_9ebe_d57dc5a07c3d
initial concentration: NaN
is: Q9NZJ6
is encoded by: hsa:51805
has only substance units: false
constant: false
type: Species
name: COQ3
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR ALADGLNexR
product: MODEL1310110012#
reversible: true
kinetic law: MODEL1310110012#
type: Reaction
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
name: L-alanine/glutamine reversible exchange

http://identifiers.org/biomodels.db/MODEL1310110012#_a08753c2_4741_4a48_8e32_b4c3a61e64dd
name: DHFR
is encoded by: hsa:1719
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is: P00374
constant: false
type: Species
initial concentration: NaN

metaR PA HSter
name: phosphatidate scramblase
type: Reaction
kinetic law: MODEL1310110012#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:

metaR RE1796M
is: SBO:0000176
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: true
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.1.1.145
modifier: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
name: RE1796
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_9ee174be_c645_4bf2_971f_1d355ad7c809
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: Q96HD9
has only substance units: false
boundary condition: true
name: ACY3
is: SBO:0000252
is encoded by: hsa:91703

metaM C02528 r
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00518
initial concentration: 1.0
is: CHEBI:36234
constant: false
initial amount: NaN
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
boundary condition: false
name: chenodeoxycholate

metaR r0355
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110012#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
fast: false
product: MODEL1310110012#
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/4.2.1.3
name: Glycolysis / Glyconeogenesis EC:2.7.1.1

http://identifiers.org/biomodels.db/MODEL1310110012#_d3b78775_3c9a_4c8f_bee5_9a6531a4090a
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is: E7EPT3
is encoded by: hsa:501
boundary condition: true
initial amount: NaN
name: ALDH7A1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_9abd463b_90cc_45fc_a32d_9cd6751ef2c3
is encoded by: hsa:6521
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: P02730
constant: false
has only substance units: false
name: SLC4A1
type: Species
initial amount: NaN

metaM lald D c
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB06458
initial concentration: 1.0
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
is: CHEBI:17167
boundary condition: false
constant: false
name: (R)-lactaldehyde
has only substance units: false

metaM CE5236 c
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB03952
constant: false
has only substance units: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
name: O2'-4a-cyclic-tetrahydrobiopterin
is: SBO:0000247
boundary condition: false
is: CHEBI:28002

metaM nadph r
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: CHEBI:57783
is: HMDB00221
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: C00005
type: Species
constant: false
boundary condition: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005

http://identifiers.org/biomodels.db/MODEL1310110012#_50ab0169_df61_4f2f_b0a1_6b3a715624dc
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
name: _AA081045_1_e
is encoded by: hsa:AA081045

metaR ALAR
fast: false
kinetic law: MODEL1310110012#
is described by: ECO:0000212
modifier: MODEL1310110012#
reactant: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
reversible: true
name: alanine racemase

metaR GLB1
is: SBO:0000176
is described by: ECO:0000000
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110012#
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
name: Beta-galactosidase

metaM hdd2coa m
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
boundary condition: false
is: CHEBI:61526
has only substance units: false
constant: false
name: trans-Hexadec-2-enoyl-CoA
initial concentration: 1.0
is: HMDB03945
type: Species
is: C05272
is: SBO:0000247
initial amount: NaN

metaR THRSERNaEx
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
name: L-serine/L-threonine Na-dependent exchange (Thr-L in)
type: Reaction
is: SBO:0000185
reactant: MODEL1310110012#
reversible: false
product: MODEL1310110012#
is described by: ECO:0000269

metaR DCSPTN1t
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
product: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: fatty acid transport via diffusion

metaM CE2431 m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
constant: false
name: cis-deca-4-enoyl-CoA
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:57795
boundary condition: false
initial amount: NaN
type: Species

metaR FUCtly
is: SBO:0000185
product: MODEL1310110012#
kinetic law: MODEL1310110012#
name: L-fucose efflux from lysosome
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
type: Reaction
reactant: MODEL1310110012#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_2fce9054_c8e1_4cba_9838_e136b81fb0c5
boundary condition: true
is: O00330
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
name: PDHX
constant: false
has only substance units: false
is encoded by: hsa:8050

http://identifiers.org/biomodels.db/MODEL1310110012#_958b0e60_94ef_4f70_89e5_dc24e649e814
has only substance units: false
is encoded by: hsa:35
initial concentration: NaN
is: P16219
type: Species
is: SBO:0000252
boundary condition: true
name: ACADS
initial amount: NaN
constant: false

metaR DGK2m
name: deoxyguanylate kinase (dGMP:dATP) (mitochondrial)
kinetic law: MODEL1310110012#
reversible: true
reactant: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.8 Confidence Level: 2 AUTHORS: NOTES:Added EC- JLR IT
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

metaR r0580
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.3.99.7
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
fast: false
reactant: MODEL1310110012#
reversible: true
modifier: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_6c3a3736_f5c5_42a5_8741_5604ed8c6786
type: Species
name: UEVLD
has only substance units: false
is encoded by: hsa:55293
is: Q8IX04
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false

metaR DINt
name: deoxyinosine transport via diffusion
reversible: true
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
product: MODEL1310110012#
type: Reaction
fast: false

metaR FUCASE2ly
fast: false
type: Reaction
modifier: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.51
name: alpha-fucosidase, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000176

metaR 4MOPt2im
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
product: MODEL1310110012#
type: Reaction
reversible: false
kinetic law: MODEL1310110012#
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport

http://identifiers.org/biomodels.db/MODEL1310110012#_8a53f445_d3a1_4935_baa1_756e71ccca28
boundary condition: true
has only substance units: false
is encoded by: hsa:1345
is: SBO:0000252
initial concentration: NaN
is: P09669
type: Species
initial amount: NaN
constant: false
name: COX6C

metaR OCD11CRNCPT2
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_358d85f4_e9bc_450f_875d_1828b36b9c5c
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: P13995
is: SBO:0000252
is encoded by: hsa:10797
boundary condition: true
name: MTHFD2

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaM cysam c
constant: false
boundary condition: false
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
is: CHEBI:58029
has only substance units: false
name: cysteaminium
is: HMDB02991
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species

metaR GLYtp
type: Reaction
is described by: ECO:0000000
product: MODEL1310110012#
reversible: true
is: SBO:0000185
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
fast: false
name: glycine passive transport to peroxisome
kinetic law: MODEL1310110012#

metaR r1666
is: SBO:0000185
type: Reaction
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport
reversible: true
product: MODEL1310110012#
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000000

metaM nadh m
is: HMDB01487
initial concentration: 1.0
is: CHEBI:57945
has only substance units: false
is: C00004
is: http://identifiers.org/pubchem.compound/3306
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
name: Nicotinamide adenine dinucleotide - reduced

metaR OCCOAtx
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110012#
name: fatty acid intracellular transport
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#

metaR GBSIDEte
name: globoside transport
reversible: true
type: Reaction
product: MODEL1310110012#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - The goal of this transporter is to get globoside to the EC plasma membrane NJ
kinetic law: MODEL1310110012#
is: SBO:0000185
reactant: MODEL1310110012#

metaR EX 3hdececrn
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecenoyl carnitine
type: Reaction

metaM dectricoa x
type: Species
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
initial concentration: 1.0
name: 2,4,7-decatrienoylcoa
is: SBO:0000247
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
constant: false
has only substance units: false
boundary condition: false

metaM adrncrn m
has only substance units: false
name: Adrenyl carnitine
boundary condition: false
notes: FORMULA: C29H49NO4 CHARGE: 0
is: SBO:0000247
type: Species
is: C00318
constant: false
is: HMDB00062
initial concentration: 1.0
is: CHEBI:16347
initial amount: NaN

metaM digalside hs c
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
is: SBO:0000247
is: C06126
is: http://identifiers.org/pubchem.compound/8383
name: Digalactosylceramide
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
constant: false

metaM ksii core4 l
boundary condition: false
is: HMDB03418
initial amount: NaN
name: keratan sulfate II (core 4-linked)
constant: false
has only substance units: false
type: Species
is: CHEBI:16443
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C89H142N7O72S3X CHARGE: -4

metaM HC02216 e
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
constant: false
type: Species
name: prostaglandin-f2beta
is: CHEBI:28922
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_86d1ca0e_925a_4f7a_ac0c_4b3bc5374e92
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8897
constant: false
type: Species
initial amount: NaN
name: MTMR3

metaM am6sa c
notes: FORMULA: C6H7NO3 CHARGE: 0 INCHI: InChI=1S/C6H7NO3/c7-5(6(9)10)3-1-2-4-8/h1-4H,7H2,(H,9,10)/p-1/b2-1-,5-3+ HEPATONET_1.0_ABBREVIATION: HC01186 EHMN_ABBREVIATION: C03824
initial concentration: 1.0
type: Species
is: HMDB01280
initial amount: NaN
is: CHEBI:57495
constant: false
is: SBO:0000247
name: 2-aminomuconate 6-semialdehyde(1-)
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_fc54901a_57de_46c3_8230_9518ae7353b6
initial concentration: NaN
name: AKR1C1
is: Q04828
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:1645
type: Species
initial amount: NaN

metaM dece4coa x
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB02145
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
name: 4-decenoylcoa
initial concentration: 1.0
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_4d5e32ca_11bf_4ad1_b117_27f91387f74f
initial amount: NaN
constant: false
is: SBO:0000252
name: B3GALNT1
type: Species
is encoded by: hsa:8706
is: O75752
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR MECOAS1m
is version of: http://identifiers.org/ec-code/6.2.1.4
name: mesaconate--CoA ligase (GDP-forming)
modifier: MODEL1310110012#
is described by: ECO:0000304
reactant: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
kinetic law: MODEL1310110012#
fast: false

metaR r1667
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110012#
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000185
modifier: MODEL1310110012#
name: Y+LAT2 Utilized transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110012#_e179cc2d_dc34_4479_904b_23346bf67074
type: Species
is: SBO:0000252
name: LPL
is: P06858
is encoded by: hsa:4023
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM asn L m
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
has only substance units: false
constant: false
is: CHEBI:17196
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: L-asparagine
is: SBO:0000247
type: Species
is: HMDB00168

http://identifiers.org/biomodels.db/MODEL1310110012#_19cfbb74_6d4b_4076_a333_9237d1d88058
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
name: ATP5G3
is encoded by: hsa:518
is: P48201
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_f4dcfd01_ae4e_41f3_b05f_576846d4a708
initial amount: NaN
constant: false
name: CHAT
has only substance units: false
is: SBO:0000252
boundary condition: true
is: P28329
is encoded by: hsa:1103
initial concentration: NaN
type: Species

metaR LINKDEG2ly
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000000
fast: false
name: degradation of proteoglycan linkage region, lysosomal
product: MODEL1310110012#
is: SBO:0000176
type: Reaction

metaR GARFT
is version of: http://identifiers.org/ec-code/2.1.2.2
is described by: ECO:0000269
fast: false
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110012#
reversible: true
product: MODEL1310110012#
kinetic law: MODEL1310110012#
name: phosphoribosylglycinamide formyltransferase

metaM 3decdicoa m
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
constant: false
name: 3,7-decadienoylcoa
is: http://identifiers.org/pubchem.compound/16019966
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_d47a1393_e93b_486c_97bb_c4a6e341fb51
is encoded by: hsa:5277
is: P37287
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
type: Species
initial amount: NaN
has only substance units: false
name: PIGA

metaM sucr e
has only substance units: false
is: HMDB00258
is: CHEBI:17992
type: Species
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00091 EHMN_ABBREVIATION: C00089
initial amount: NaN
name: Sucrose
constant: false
is: C00089
initial concentration: 1.0
is: SBO:0000247

metaR PGMT
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/5.4.2.2
type: Reaction
reversible: true
is: SBO:0000176
modifier: MODEL1310110012#
fast: false
name: phosphoglucomutase
product: MODEL1310110012#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:
kinetic law: MODEL1310110012#

metaM ksii core4 g
is: HMDB03418
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16443
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
name: keratan sulfate II (core 4-linked)
constant: false
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_metaM_galacglc13galacglcgal14acglcgalgluside_hs_g
type: Species
is: CHEBI:26174
boundary condition: false
initial amount: NaN
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
name: nLc8Cer

http://identifiers.org/biomodels.db/MODEL1310110012#_886237f7_50d1_4f42_8376_f179bd1d0b59
is encoded by: hsa:7372
boundary condition: true
is: A8K5J1
is: SBO:0000252
initial amount: NaN
name: UMPS
constant: false
type: Species
initial concentration: NaN
has only substance units: false

metaR PCRNtm
name: transport into the mitochondria from cytosol (carnitine)
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
fast: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000185

metaR DHDPBMTm
type: Reaction
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: 2.1.1.114 Confidence Level: 4 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.1.1.114 IT
fast: false
product: MODEL1310110012#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
name: dihydroxydecaprenylbenzoate methyltransferase
is version of: http://identifiers.org/ec-code/2.1.1.114
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110012#_a2647f4f_fe69_42ef_8de6_3a84b89302d1
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial concentration: NaN
name: PIGN
initial amount: NaN
is encoded by: hsa:23556
has only substance units: false

metaM dcsptn1coa m
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
boundary condition: false
has only substance units: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205483
is: SBO:0000247
constant: false
is: HMDB06513
type: Species
is: C16173
initial concentration: 1.0

metaR r1106
fast: false
kinetic law: MODEL1310110012#
is described by: ECO:0000000
product: MODEL1310110012#
reactant: MODEL1310110012#
name: Postulated transport reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110012#_e9d70f3c_610b_47d8_bf99_224bfe96faa5
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: GCNT1
boundary condition: true
is: Q02742
is encoded by: hsa:2650
type: Species
initial concentration: NaN

metaM gly m
has only substance units: false
type: Species
is: C00037
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00123
name: Glycine
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
initial concentration: 1.0
is: CHEBI:15428
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_98d9a52b_13f3_45e4_a86d_9ca0aae96105
name: ACAA1
initial concentration: NaN
is encoded by: hsa:30
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is: Q96CA6
has only substance units: false

metaR GLYtm
reactant: MODEL1310110012#
is: SBO:0000185
fast: false
reversible: true
name: glycine passive transport to mitochondria
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
product: MODEL1310110012#
type: Reaction
is described by: ECO:0000000

metaM hexdiac r
is: SBO:0000247
is: C08260
name: hexadecanediocacid
constant: false
is: HMDB00672
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C16H28O4 CHARGE: -2
initial amount: NaN
has only substance units: false

metaR ADK1
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000269
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
name: adenylate kinase
type: Reaction
modifier: MODEL1310110012#
product: MODEL1310110012#

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR HSAT2ly
is: SBO:0000185
reactant: MODEL1310110012#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
product: MODEL1310110012#
kinetic law: MODEL1310110012#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
type: Reaction
is described by: ECO:0000000

metaR C141CPT1
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecenoylcarnitine
type: Reaction

metaR EX 3ttetddcoacrn
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy trans5,8tetradecadienoyl carnitine
type: Reaction

metaM malttr e
is: CHEBI:27931
is: HMDB01262
name: maltotriose
type: Species
boundary condition: false
is: C01835
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835

metaR r0354
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is: SBO:0000176
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
fast: false
type: Reaction
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_c49bdb8a_db70_4a38_ad90_a09a6f616adf
has only substance units: false
is: P49619
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1608
name: DGKG

http://identifiers.org/biomodels.db/MODEL1310110012#_44f14d95_7702_46cb_9db3_31ecd49ea79a
name: AMY1A
is encoded by: hsa:276
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: Q6NSB3
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR FAOXC143C123m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

metaR EHGLAT2m
is: SBO:0000176
kinetic law: MODEL1310110012#
fast: false
product: MODEL1310110012#
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110012#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
type: Reaction
reversible: false
modifier: MODEL1310110012#

metaM 3dpdhb m
boundary condition: false
name: 3-Decaprenyl-4,5-dihdydroxybenzoate
is: CHEBI:50775
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C57H85O4 CHARGE: -1 INCHI: InChI=1S/C57H86O4/c1-43(2)21-12-22-44(3)23-13-24-45(4)25-14-26-46(5)27-15-28-47(6)29-16-30-48(7)31-17-32-49(8)33-18-34-50(9)35-19-36-51(10)37-20-38-52(11)39-40-53-41-54(57(60)61)42-55(58)56(53)59/h21,23,25,27,29,31,33,35,37,39,41-42,58-59H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,60,61)/b44-23+,45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+

http://identifiers.org/biomodels.db/MODEL1310110012#_34662dfd_727f_4ec0_b9a8_981e040631e9
type: Species
is: SBO:0000252
is encoded by: hsa:4512
initial amount: NaN
is: Q7GXY8
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
name: COX1

http://identifiers.org/biomodels.db/MODEL1310110012#_26e531e3_50ab_4df2_98e5_4fd8e542f161
type: Species
boundary condition: true
name: ALDH3B2
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:222
initial concentration: NaN
is: P48448

http://identifiers.org/biomodels.db/MODEL1310110012#_11b91385_5733_4c6c_a9b0_82fc92d3bff5
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:124
is: P07327
name: ADH1A
type: Species
constant: false
has only substance units: false

metaM hexe3coa m
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB06522
name: 3-hexenoylcoa
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
type: Species
constant: false
initial concentration: 1.0

metaR TYRTAm
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.1
type: Reaction
name: tyrosine transaminase, mitochondrial
notes: GENE_ASSOCIATION: (6898.1) or (2806.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: PMID:1973834 NOTES:NCD
is: SBO:0000176
reversible: true
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.6.1.5
kinetic law: MODEL1310110012#
is described by: ECO:0000269
product: MODEL1310110012#

metaR XYLtly
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
type: Reaction
name: Xylose efflux from lysosome
reactant: MODEL1310110012#
fast: false

metaM nadh r
name: NADH(2-)
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
is: HMDB01487
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57945
initial concentration: 1.0

metaR ALR2
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is described by: ECO:0000269
name: aldose reductase (methylglyoxal)
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110012#
reversible: false
fast: false
kinetic law: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.21
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_b81b7415_d272_4815_9d68_ecfe93400012
constant: false
initial amount: NaN
is encoded by: hsa:28232
initial concentration: NaN
is: Q9UIG8
is: SBO:0000252
boundary condition: true
type: Species
name: SLCO3A1
has only substance units: false

metaR EICOSTETCPT1
product: MODEL1310110012#
name: carnitine O-palmitoyltransferase
kinetic law: MODEL1310110012#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
modifier: MODEL1310110012#
is: SBO:0000176
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_59425f97_292e_4738_abc7_b7fa939ce03a
boundary condition: true
initial concentration: NaN
is encoded by: hsa:219
has only substance units: false
is: P30837
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
name: ALDH1B1

http://identifiers.org/biomodels.db/MODEL1310110012#_b6da0463_d461_4da6_9516_56165ca338c5
is encoded by: hsa:4706
initial concentration: NaN
is: O14561
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: NDUFAB1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_cedfe6da_004d_4af5_a970_45adc9ce6f65
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:AI620219
name: _AI620219_1_m
boundary condition: true
constant: false

metaM mpdol U c
boundary condition: false
notes: FORMULA: C1245H2040N20O220P20 CHARGE: -20
has only substance units: false
type: Species
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:18396
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_6b4be65c_5f12_4904_b8fa_889d31a636fe
is encoded by: hsa:30
is: Q96CA6
type: Species
is: SBO:0000252
name: ACAA1
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

metaR ADK3
product: MODEL1310110012#
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.4.3
modifier: MODEL1310110012#
name: adentylate kinase (GTP)
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110012#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR

metaR GBSIDEtl
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) NJ
kinetic law: MODEL1310110012#
is: SBO:0000185
type: Reaction
product: MODEL1310110012#
is described by: ECO:0000000
reactant: MODEL1310110012#
reversible: true
name: globoside intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110012#_0f3ec729_c1cf_45c5_966d_14f8628cbece
is: Q02846
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3000
constant: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
name: GUCY2D

metaR C160CPT2
kinetic law: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#
reversible: false
name: C160 transport into the mitochondria
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
fast: false
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
is described by: ECO:0000269

metaR r1661
is described by: ECO:0000000
kinetic law: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110012#_fc610709_7dec_48ee_bf8e_299898fe6d39
is encoded by: hsa:7001
has only substance units: false
name: PRDX2
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaM adrncrn c
notes: FORMULA: C29H49NO4 CHARGE: 0
is: CHEBI:16347
type: Species
initial concentration: 1.0
boundary condition: false
is: C00318
is: HMDB00062
constant: false
has only substance units: false
is: SBO:0000247
name: Adrenyl carnitine
initial amount: NaN

metaR FAOXTC102C101m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:2-->C10:1)m
type: Reaction

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_880ee89b_16b3_47d2_96b1_5d5dc2a45a8e
constant: false
has only substance units: false
type: Species
initial concentration: NaN
name: CH25H
initial amount: NaN
boundary condition: true
is: O95992
is: SBO:0000252
is encoded by: hsa:9023

http://identifiers.org/biomodels.db/MODEL1310110012#_608ddbb4_c00d_4617_880a_e810052d6333
is: SBO:0000252
is encoded by: hsa:760
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
name: CA2
constant: false
is: P00918

metaR PRO Dtde
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
product: MODEL1310110012#
name: D-proline transport, extracellular
type: Reaction
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.

metaM ksi deg10 l
is: HMDB00812
is: SBO:0000247
constant: false
name: keratan sulfate I, degradation product 10
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C188H302N13O163S9 CHARGE: -9
initial amount: NaN
is: CHEBI:16953

metaR C160CPT1
type: Reaction
product: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:
is: SBO:0000176
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.21
name: production of Palmitoylcarnitine
is described by: ECO:0000269
kinetic law: MODEL1310110012#
reversible: false

metaR TMNDNCt
type: Reaction
kinetic law: MODEL1310110012#
name: fatty acid transport via diffusion
is described by: ECO:0000000
reversible: true
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110012#
fast: false
is: SBO:0000185

metaM cl e
is: CHEBI:3966
constant: false
notes: FORMULA: Cl CHARGE: -1
name: Chloride
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: C00115
initial concentration: 1.0
is: HMDB00492
boundary condition: false

metaM tmndnccoa c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
name: timnodonyl coenzyme A
is: HMDB06514
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
type: Species
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_a1b5d4c0_1637_41c3_93a7_59f9d81a368a
has only substance units: false
constant: false
name: GUCY1A2
is: P33402
is encoded by: hsa:2977
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM pydx5p e
type: Species
name: pyridoxal 5'-phosphate(2-)
initial concentration: 1.0
has only substance units: false
is: HMDB01491
is: CHEBI:597326
constant: false
boundary condition: false
notes: FORMULA: C8H8NO6P CHARGE: -2 INCHI: InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)/p-2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
initial amount: NaN
is: SBO:0000247

metaR r1660
is: SBO:0000185
kinetic law: MODEL1310110012#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000000

metaM o2 m
is: CHEBI:15379
initial concentration: 1.0
name: O2
is: SBO:0000247
is: C00007
type: Species
is: HMDB01377
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_ecf23264_46da_4c48_8ec4_2c64f242ebdb
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: SLC25A4
type: Species
initial amount: NaN
is: P12235
is encoded by: hsa:291
constant: false
boundary condition: true

metaM CE5586 c
constant: false
initial amount: NaN
is: CHEBI:58732
boundary condition: false
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0

metaR r1109
reactant: MODEL1310110012#
type: Reaction
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
kinetic law: MODEL1310110012#
fast: false
product: MODEL1310110012#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110012#_43bfdae2_de0f_4b81_aed4_1a9afc84e360
boundary condition: true
is encoded by: hsa:2108
name: ETFA
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is: P13804
constant: false
initial amount: NaN

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaM 2mop m
is: HMDB01172
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:57700
name: 2-methyl-3-oxopropanoate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_17259ad1_eb6d_45b5_ad53_02f68033b721
is: A8K9Q8
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
name: B3GNT6
boundary condition: true
is encoded by: hsa:192134

http://identifiers.org/biomodels.db/MODEL1310110012#_2cebccda_02ef_4c8f_b2f4_71b05b8afd69
initial concentration: NaN
name: TXNRD3
constant: false
type: Species
is: Q86VQ6
has only substance units: false
is encoded by: hsa:114112
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR CYTDn
reactant: MODEL1310110012#
name: cytidine deaminase, nuclear
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.5
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#
reversible: false
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:
type: Reaction
is described by: ECO:0000254

metaR r0139
is: SBO:0000176
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
kinetic law: MODEL1310110012#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.2.2
product: MODEL1310110012#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

metaM o2 n
is: SBO:0000247
boundary condition: false
name: dioxygen
initial concentration: 1.0
type: Species
is: CHEBI:15379
constant: false
initial amount: NaN
is: HMDB01377
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007

http://identifiers.org/biomodels.db/MODEL1310110012#_6f28b1df_4988_4e96_8408_81a188dee894
name: GGT5
initial concentration: NaN
is: P36269
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2687
initial amount: NaN
type: Species
constant: false

metaR NACHEX2ly
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110012#
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110012#
fast: false

metaR C142CPT1
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecadienoylcarnitine
type: Reaction

metaR PCHOLPg hs
is: SBO:0000176
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.4
is described by: ECO:0000269
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: false
reactant: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
name: choline phosphatase

http://identifiers.org/biomodels.db/MODEL1310110012#_19e4d8fb_3f96_4fd0_b5af_96830b34a42c
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
constant: false
is encoded by: hsa:4731
is encoded by: hsa:4712
has part: Q5VYT2
boundary condition: true
is: SBO:0000297
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_95642f0b_ceb4_46f5_b333_fe5168683821
constant: false
initial concentration: NaN
is encoded by: hsa:10166
is: Q9Y619
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
name: SLC25A15

metaM acgam r
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
type: Species
is: HMDB00215
initial concentration: 1.0
name: N-acetyl-D-glucosamine
is: CHEBI:17411
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial amount: NaN

metaM c4crn c
has only substance units: false
type: Species
name: butyryl carnitine
is: SBO:0000247
boundary condition: false
notes: FORMULA: C11H21NO4 CHARGE: 0
constant: false
is: C02862
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/213144
is: HMDB02013

http://identifiers.org/biomodels.db/MODEL1310110012#_58d9c47f_e536_4592_b64b_1a98c4c179b9
name: ACADM
boundary condition: true
is: P11310
is: SBO:0000252
is encoded by: hsa:34
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
has only substance units: false

metaR EX dmhptcrn LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2,6 dimethylheptanoyl carnitine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_43817e51_dec6_400a_8162_6400fbde5d8a
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
name: PDXK
is encoded by: hsa:8566
is: O00764
is: SBO:0000252
type: Species

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_25553bab_1da0_42a7_bee8_03eb283dc913
is: O00483
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: NDUFA4
is encoded by: hsa:4697
type: Species
constant: false

metaR EX thf LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_1249c907_1cbb_41ea_b857_e3e0be922a5f
is: SBO:0000297
has part: P31350
name: RRM1:RRM2
has part: P23921
boundary condition: true
initial amount: NaN
is encoded by: hsa:6241
has only substance units: false
type: Species
constant: false
is encoded by: hsa:6240
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_74b91793_4aba_4418_ad94_ce395663e387
name: NOS3
initial amount: NaN
is: A0S0A7
type: Species
constant: false
is encoded by: hsa:4846
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR r1665
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110012#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110012#
product: MODEL1310110012#
name: Y+LAT2 Utilized transport
reversible: true

metaR SERGLNexR
name: L-Serine/Glutamine reversible exchange
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110012#
product: MODEL1310110012#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000304

metaM c226crn c
type: Species
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
has only substance units: false
is: HMDB06510
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
name: cervonyl carnitine
is: http://identifiers.org/pubchem.compound/127055

metaR r2088
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110012#
is: SBO:0000185
reactant: MODEL1310110012#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110012#
product: MODEL1310110012#

metaR r2193
type: Reaction
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR AG13T9g
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110012#
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
fast: false

metaR CRNtim
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reversible: false
name: L-carnitine transport out of mitochondria via diffusion
fast: false
modifier: MODEL1310110012#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_833edc74_bf12_4dc7_9b07_283d28f0cdbb
initial concentration: NaN
name: HLCS
initial amount: NaN
has only substance units: false
is: P50747
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is encoded by: hsa:3141

metaM dlnlcgcrn c
is: HMDB01311
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:16004
initial amount: NaN
type: Species
is: SBO:0000247
name: dihomo-gamma-linolenyl carnitine
initial concentration: 1.0

metaM dhf e
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: HMDB01056
type: Species
boundary condition: false
has only substance units: false
constant: false
name: dihydrofolate(2-)
is: CHEBI:57451

metaM zymstnl r
initial amount: NaN
type: Species
is: CHEBI:16608
name: 5alpha-cholest-8-en-3beta-ol
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB06841

metaR r2089
kinetic law: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110012#
fast: false
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM gacpail hs c
is: SBO:0000247
is: CHEBI:16344
constant: false
has only substance units: false
is: HMDB00128
type: Species
initial concentration: 1.0
initial amount: NaN
name: glucosaminyl-acylphosphatidylinositol
boundary condition: false
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0

metaM acglcgal14acglcgalgluside hs g
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:17103
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
name: nLc5Cer
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0

metaM acgam l
type: Species
is: CHEBI:17411
initial concentration: 1.0
is: HMDB00215
name: N-acetyl-D-glucosamine
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: SBO:0000247
constant: false
boundary condition: false

metaM ksii core2 pre4 g
notes: FORMULA: C53H86N4O38X CHARGE: -1
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 4
type: Species
is: CHEBI:58053
has only substance units: false
is: C00130
is: HMDB00175

metaM nadph m
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: C00005
constant: false
is: CHEBI:57783
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: SBO:0000247
is: HMDB00221

http://identifiers.org/biomodels.db/MODEL1310110012#_f6a7d7f8_4d69_4836_8bbc_c2f456819f0a
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is: B2R6S5
name: CMPK1
type: Species
initial concentration: NaN
is encoded by: hsa:51727
boundary condition: true

metaR CHOLt4
is: SBO:0000185
kinetic law: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
modifier: MODEL1310110012#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
name: choline, sodium cotransport

http://identifiers.org/biomodels.db/MODEL1310110012#_9e6e1d69_96d0_4831_8a73_554b98b0d2fc
initial concentration: NaN
boundary condition: true
name: CA6
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:765
type: Species
has only substance units: false
is: Q5FC00

http://identifiers.org/biomodels.db/MODEL1310110012#_b3d6a5f8_e108_4f8f_85cd_817321531e0e
is encoded by: hsa:7296
name: TXNRD1
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN

metaR r1664
name: Y+LAT2 Utilized transport
type: Reaction
reversible: true
product: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaR r0287
modifier: MODEL1310110012#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction
product: MODEL1310110012#
fast: false
is: SBO:0000176
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_4f3e2db0_1882_4c64_9347_c986323f9695
is encoded by: hsa:3419
has part: P50213
type: Species
has only substance units: false
has part: E9PDD5
is: SBO:0000297
name: IDH3A:IDH3B:IDH3G
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:3420
is encoded by: hsa:3421
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_d8a3d6e8_04b2_46a9_85f1_e525cd3fdb4b
is: SBO:0000252
is encoded by: hsa:9517
type: Species
boundary condition: true
name: SPTLC2
is: O15270
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_98bd5c47_41d3_4d17_8544_6be18f0de85e
initial amount: NaN
has only substance units: false
name: FUCA1
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is: P04066
is encoded by: hsa:2517
constant: false

metaR MEOHt2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110012#
name: Methanol diffusion
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000185

metaR r1952
modifier: MODEL1310110012#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport
reactant: MODEL1310110012#
fast: false
product: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false

metaR r2195
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
reactant: MODEL1310110012#
product: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
reversible: true
type: Reaction

metaR GGH 7THFe
reactant: MODEL1310110012#
product: MODEL1310110012#
name: Gamma-glutamyl hydrolase (7THF), extracellular
modifier: MODEL1310110012#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110012#
fast: false
is: SBO:0000176

metaR VLCSp
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110012#
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: false
type: Reaction
reactant: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
name: Very-long-chain-fatty-acid-CoA ligase

http://identifiers.org/biomodels.db/MODEL1310110012#_b7b4e14b_9a4b_4769_b3a7_44c5911091d4
is: SBO:0000252
is: Q9H0N5
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
name: PCBD2
is encoded by: hsa:84105

metaM o2 r
boundary condition: false
name: O2
initial amount: NaN
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
type: Species
constant: false
is: HMDB01377
has only substance units: false
initial concentration: 1.0
is: C00007
is: CHEBI:15379

metaR r2196
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110012#
fast: false
product: MODEL1310110012#
modifier: MODEL1310110012#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110012#

metaR DNDPt33m
type: Reaction
is: SBO:0000185
modifier: MODEL1310110012#
name: dGDP transport via dUDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
product: MODEL1310110012#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_97975afa_e01f_404b_bace_324e3d69a6f2
type: Species
initial concentration: NaN
is: SBO:0000252
name: _MBOAT5_1_c
constant: false
has only substance units: false
is encoded by: hsa:MBOAT5
initial amount: NaN
boundary condition: true

metaR F6Tg
reactant: MODEL1310110012#
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.68
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
name: glycoprotein 6-alpha-L-fucosyltransferase

metaR KYNAKGAT
fast: false
name: L-Kynurenine:2-oxoglutarate aminotransferase
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
reversible: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.6.1.7
is version of: http://identifiers.org/ec-code/2.6.1.64
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB

metaM cl c
initial amount: NaN
boundary condition: false
is: CHEBI:3966
is: C00115
initial concentration: 1.0
type: Species
notes: FORMULA: Cl CHARGE: -1
is: HMDB00492
constant: false
name: Chloride
has only substance units: false
is: SBO:0000247

metaR PGLer
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
fast: false
is described by: ECO:0000269
product: MODEL1310110012#
kinetic law: MODEL1310110012#
name: 6-phosphogluconolactonase, endoplasmic reticulum
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.47
reversible: false
reactant: MODEL1310110012#
type: Reaction

metaR S6TASE14ly
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reversible: true

metaM C02528 c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: chenodeoxycholate
constant: false
is: HMDB00518
is: CHEBI:36234
type: Species
has only substance units: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528

metaR CYTK3n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,CTP),nuclear
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
kinetic law: MODEL1310110012#
fast: false
modifier: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
product: MODEL1310110012#

metaR FAOXC1811601m
type: Reaction
modifier: MODEL1310110012#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110012#
is: SBO:0000176
reversible: false
reactant: MODEL1310110012#
name: Beta oxidation fatty acid
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110012#_cc24663c_e0c2_40d6_825c_24bfa7502187
has only substance units: false
initial amount: NaN
is encoded by: hsa:R06874
initial concentration: NaN
constant: false
name: _R06874_1_r
boundary condition: true
is: SBO:0000252
type: Species

metaM ddcacoa m
constant: false
initial amount: NaN
is: C01832
has only substance units: false
name: Dodecanoyl-CoA (n-C12:0CoA)
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB03571
type: Species
is: CHEBI:57375

metaR XYLt
reactant: MODEL1310110012#
modifier: MODEL1310110012#
fast: false
is described by: ECO:0000269
is: SBO:0000185
name: D-xylose reversible transport
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
reversible: true
product: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_a80061ab_95e7_484d_a6f5_245da4ec5dbc
name: PDE9A
constant: false
has only substance units: false
is encoded by: hsa:5152
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR DIGALSIDEtl
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
name: digalside hs intracellular transport
product: MODEL1310110012#
is described by: ECO:0000000
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
is: SBO:0000185
reversible: true

metaM pydx5p c
is: C00018
type: Species
is: HMDB01491
boundary condition: false
notes: FORMULA: C8H8NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
is: CHEBI:597326
constant: false
initial concentration: 1.0
is: SBO:0000247
name: Pyridoxal 5'-phosphate
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_42294d40_d4b8_4c82_8d9d_f70d1f6addf6
has only substance units: false
name: _AW277253_1_c
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:AW277253
initial concentration: NaN

metaR r1662
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110012#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_a9ab135c_3449_46d9_a2b7_7deb35bb2189
is: SBO:0000252
name: DPYD
initial amount: NaN
is encoded by: hsa:1806
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q12882
constant: false
type: Species

metaR OCDEAFABP1tc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of octadecenoyl coA into the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_1b498c6d_71f1_49cf_844f_eb954feab0d5
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:10400
has only substance units: false
name: PEMT
type: Species
initial amount: NaN
is: SBO:0000252

metaM ins c
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17596
name: Inosine
is: C00294
is: HMDB00195
initial concentration: 1.0
type: Species
constant: false

metaM CE5120 m
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: trans-2-cis-8-tetradecadienoyl-CoA
is: SBO:0000247
constant: false
is: CHEBI:57923
type: Species

metaR r1433
product: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaR r2084
reversible: true
fast: false
reactant: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000185
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110012#_0c28e57c_16b2_4d34_bb8e_b410f315c16a
name: _AI935189_1_m
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI935189
boundary condition: true
constant: false
initial concentration: NaN
type: Species
has only substance units: false

metaR SERTHRNaEx
name: L-serine/L-threonine Na-dependent exchange (Ser-L in)
modifier: MODEL1310110012#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
kinetic law: MODEL1310110012#
reversible: false
reactant: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000185

metaR r2197
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000185
kinetic law: MODEL1310110012#
fast: false
product: MODEL1310110012#

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_metaM_fucgalacglc13galacglcgal14acglcgalgluside_hs_g
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)1 (Cer)1
notes: FORMULA: C78H135N4O46FULLRCO CHARGE: 0
type: Species
is: CHEBI:16094
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00257
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM ddcacoa c
is: HMDB03571
is: CHEBI:57375
is: SBO:0000247
type: Species
is: C01832
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: Dodecanoyl-CoA (n-C12:0CoA)
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_d31abfd0_94d3_4ac2_a674_823e81838ae0
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5831
has only substance units: false
name: PYCR1
initial amount: NaN
is: A6NFM2
constant: false

metaR r0130
is described by: ECO:0000000
modifier: MODEL1310110012#
product: MODEL1310110012#
kinetic law: MODEL1310110012#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
fast: false
reactant: MODEL1310110012#

metaR DCYTDn
kinetic law: MODEL1310110012#
is described by: ECO:0000254
name: deoxycytidine deaminase, nuclear
is version of: http://identifiers.org/ec-code/3.5.4.5
reversible: false
fast: false
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
product: MODEL1310110012#
type: Reaction
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110012#_28380c42_4f05_495b_bedf_e22b0423ec94
is encoded by: hsa:92579
is: Q9BUM1
type: Species
is: SBO:0000252
constant: false
name: G6PC3
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_fb2d6258_fff3_4473_b22d_c4d6429882e6
is encoded by: hsa:5331
boundary condition: true
constant: false
is: G5E960
has only substance units: false
initial concentration: NaN
name: PLCB3
type: Species
initial amount: NaN
is: SBO:0000252

metaR SEBACACT
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of sebacic acidd
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_8aa3918e_8b4c_4351_9c33_b985490ad34a
constant: false
is: Q7LG56
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:50484
has only substance units: false
type: Species
is: SBO:0000252
name: RRM2B

metaR r2085
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110012#

metaR FUT99g
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
name: Alpha-(1,3)-fucosyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.152
reactant: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
fast: false
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110012#
is described by: ECO:0000269
modifier: MODEL1310110012#

metaR H2O2t
product: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
name: hydrogen peroxide transport via diffusion
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_822faccd_b824_4226_9a85_d7755ff4207e
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: B3KQH0
boundary condition: true
name: SLC35C1
is: SBO:0000252
is encoded by: hsa:55343

metaR OAGD3tg
kinetic law: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
type: Reaction
name: oagd3 hs intracellular transport
product: MODEL1310110012#
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110012#

metaR DDPGAm
type: Reaction
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
reversible: true
is: SBO:0000176
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
reactant: MODEL1310110012#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110012#

metaR RE0512M
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE0512
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
product: MODEL1310110012#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR r2198
type: Reaction
reactant: MODEL1310110012#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reversible: true
modifier: MODEL1310110012#

metaM g2m8masn r
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C82H137N2O65X CHARGE: 0
is: C05874
is: SBO:0000247

metaR FACOAL150
type: Reaction
is described by: ECO:0000000
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110012#
is: SBO:0000176
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
fast: false
reversible: true
name: fatty-acid--CoA ligase

metaM acac m
is: CHEBI:13705
constant: false
is: HMDB00060
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
boundary condition: false
has only substance units: false
initial amount: NaN
name: acetoacetate
initial concentration: 1.0
type: Species

metaM dlnlcgcrn m
initial amount: NaN
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
initial concentration: 1.0
boundary condition: false
name: dihomo-gamma-linolenyl carnitine
constant: false
has only substance units: false
is: HMDB01311
type: Species
is: SBO:0000247
is: CHEBI:16004

metaR MAL Lte
is: SBO:0000185
reactant: MODEL1310110012#
name: Transport of L-malate
fast: false
is described by: ECO:0000134
reversible: true
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110012#

metaR r1435
type: Reaction
reactant: MODEL1310110012#
reversible: false
fast: false
name: Transport reaction
product: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110012#_ac017bc0_3732_4ba5_80b1_ed323b14d3c5
is: SBO:0000252
initial amount: NaN
is: Q9UNA3
boundary condition: true
type: Species
is encoded by: hsa:51146
initial concentration: NaN
constant: false
name: A4GNT
has only substance units: false

metaR OLEICFATPtc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_110a595d_f0ce_4557_9bb8_455e630f8a82
has part: Q07326
name: PIGF:PIGO
has part: Q8TEQ8
has only substance units: false
initial amount: NaN
is encoded by: hsa:5281
type: Species
constant: false
is encoded by: hsa:84720
initial concentration: NaN
boundary condition: true
is: SBO:0000297

metaM dhf c
has only substance units: false
constant: false
name: 7,8-Dihydrofolate
type: Species
is: CHEBI:57451
is: SBO:0000247
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial amount: NaN
boundary condition: false
is: C00415
initial concentration: 1.0
is: HMDB01056

metaR r2086
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110012#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
product: MODEL1310110012#
is: SBO:0000185
modifier: MODEL1310110012#
reactant: MODEL1310110012#

metaR r2199
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110012#
reversible: true
is: SBO:0000185
modifier: MODEL1310110012#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
fast: false
type: Reaction
product: MODEL1310110012#
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_3eda508a_c3ce_4b50_8ed3_b274383b9002
name: CRAT
has only substance units: false
is encoded by: hsa:1384
constant: false
is: SBO:0000252
initial amount: NaN
is: P43155
type: Species
initial concentration: NaN
boundary condition: true

metaR RE2660C
reactant: MODEL1310110012#
is: SBO:0000176
type: Reaction
reversible: true
is described by: ECO:0000000
name: RE2660
product: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
fast: false

metaM dcsptn1coa c
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
constant: false
is: HMDB06513
is: C16173
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205483
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR H2Oter
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: H2O endoplasmic reticulum transport
kinetic law: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_8f922f3e_3edf_4214_8b37_209b697939f0
is encoded by: hsa:251
type: Species
has only substance units: false
is: P10696
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: ALPPL2
initial amount: NaN

metaR IPDDIx
product: MODEL1310110012#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/5.3.3.2
kinetic law: MODEL1310110012#
reversible: true
is described by: ECO:0000134
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000176
name: isopentenyl-diphosphate D-isomerase
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ

metaM gly c
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:3339
notes: FORMULA: C2H5NO2 CHARGE: 0
constant: false
initial concentration: 1.0
is: HMDB00123
initial amount: NaN
name: Glycine
is: C00037

metaR NACHEX12ly
reactant: MODEL1310110012#
is: SBO:0000176
kinetic law: MODEL1310110012#
product: MODEL1310110012#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110012#
is described by: ECO:0000000

metaM ksi deg9 l
initial concentration: 1.0
is: CHEBI:12936
type: Species
initial amount: NaN
is: HMDB00143
constant: false
boundary condition: false
name: keratan sulfate I, degradation product 9
has only substance units: false
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
is: SBO:0000247

metaR r1434
is described by: ECO:0000000
fast: false
name: Transport reaction
type: Reaction
product: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
reactant: MODEL1310110012#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110012#_7334cf43_dbdb_43e1_8ca8_d8b953332aa3
initial concentration: NaN
type: Species
name: ACAA1
boundary condition: true
constant: false
is encoded by: hsa:30
is: SBO:0000252
is: Q96CA6
initial amount: NaN
has only substance units: false

metaR PROSTGE1t
kinetic law: MODEL1310110012#
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110012#
reversible: true
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
fast: false
reactant: MODEL1310110012#
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_18830634_02de_40a2_9de2_fc4f6ac60881
is: Q9NXB9
is: SBO:0000252
name: ELOVL2
is encoded by: hsa:54898
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_9179fc96_2b8b_4217_a5c1_fec36342bf9a
name: SLC4A4
type: Species
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:8671
is: SBO:0000252
boundary condition: true
is: A5JJ20
initial concentration: NaN

metaR BALAtmr
reactant: MODEL1310110012#
product: MODEL1310110012#
reversible: true
is described by: ECO:0000000
name: Beta-alanine reversible mitochondrial transport (diffusion)
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
kinetic law: MODEL1310110012#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_f3206620_e06c_4fa3_82cf_e05f14f674f0
constant: false
has only substance units: false
is: Q7GXZ1
initial amount: NaN
boundary condition: true
name: ND6
initial concentration: NaN
is encoded by: hsa:4541
is: SBO:0000252
type: Species

metaR r2087
product: MODEL1310110012#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110012#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR HMGCOAtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
fast: false
is described by: ECO:0000000
reactant: MODEL1310110012#
type: Reaction
reversible: true
product: MODEL1310110012#
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
is: SBO:0000185
kinetic law: MODEL1310110012#

metaM o2 x
is: C00007
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
is: CHEBI:15379
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
name: O2
boundary condition: false
is: HMDB01377

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_5cbbd486_3c56_4bd2_b4be_e9607d59421d
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:27235
is: Q96H96
boundary condition: true
name: COQ2
is: SBO:0000252
initial concentration: NaN
type: Species

metaR FAOXC16080m
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110012#
type: Reaction
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
reactant: MODEL1310110012#

metaM thcrm hs g
is: CHEBI:24636
type: Species
boundary condition: false
is: SBO:0000247
constant: false
name: trihexosyl ceramide
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
has only substance units: false

metaR ESTRADIOLtr
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000185
name: estradiol intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
product: MODEL1310110012#

metaR S6TASE11ly
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110012#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
fast: false
modifier: MODEL1310110012#
product: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction

metaM perillyl c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
name: perillyl alcohol
notes: FORMULA: C10H16O CHARGE: 0 INCHI: InChI=1S/C10H16O/c1-8(2)10-5-3-9(7-11)4-6-10/h3,10-11H,1,4-7H2,2H3 EHMN_ABBREVIATION: C02452
initial amount: NaN
is: CHEBI:15420
is: HMDB03634
boundary condition: false
constant: false

metaR r2080
kinetic law: MODEL1310110012#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110012#
reversible: true
reactant: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR EX glygn5 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 5 (glycogenin-2[1,4-Glc])
type: Reaction

metaR RE0935E
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.17
name: RE0935
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110012#
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1

metaR SIAASE4ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: sialidase, lysosomal
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
product: MODEL1310110012#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
is: SBO:0000176
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#

metaM c6crn x
has only substance units: false
is: HMDB00705
initial amount: NaN
type: Species
boundary condition: false
name: hexanoyl carnitine
constant: false
initial concentration: 1.0
notes: FORMULA: C13H25NO4 CHARGE: 0
is: SBO:0000247

metaM c8crn e
boundary condition: false
constant: false
name: octanoyl carnitine
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00791
type: Species
is: C02838
notes: FORMULA: C15H29NO4 CHARGE: 0
initial amount: NaN

metaR DTDPtn
is: SBO:0000185
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110012#
name: dTDP nuclear transport
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110012#

metaM ksi deg19 l
is: SBO:0000247
name: keratan sulfate I, degradation product 19
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: CHEBI:16953
initial amount: NaN
is: HMDB00812
notes: FORMULA: C146H236N10O124S6 CHARGE: -6

metaM h c
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
boundary condition: false
name: proton
constant: false
is: C00080
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: "

http://identifiers.org/biomodels.db/MODEL1310110012#_55a1b3c4_ac3c_407e_8198_96b99b24c324
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:8879
constant: false
name: SGPL1
is: SBO:0000252
initial amount: NaN
is: O95470

metaM xolest2 hs e
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
name: cholesterol ester
type: Species
is: CHEBI:17002
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_fffed29d_bee9_47aa_92da_a0891def7358
is: SBO:0000252
type: Species
is encoded by: hsa:1375
name: CPT1B
constant: false
boundary condition: true
is: Q92523
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_2bda860f_7c51_4da9_a7f6_5709738e0de2
boundary condition: true
name: SLCO2A1
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is: Q92959
type: Species
is encoded by: hsa:6578
initial amount: NaN

metaM 2mbcoa m
is: HMDB01041
constant: false
name: 2-methylbutanoyl-CoA(4-)
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:57336
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033

metaR r2081
modifier: MODEL1310110012#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
kinetic law: MODEL1310110012#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000185

metaM retinal c
name: retinal
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB01358
boundary condition: false
type: Species
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
constant: false
is: CHEBI:15035

metaR IDOAASE3ly
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
is: SBO:0000176
name: alpha-L-iduronidase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.76
fast: false
reversible: false
product: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD

metaM taur e
initial amount: NaN
is: CHEBI:3544
boundary condition: false
name: Taurine
initial concentration: 1.0
notes: FORMULA: C2H7NO3S CHARGE: 0
is: SBO:0000247
constant: false
type: Species
has only substance units: false
is: C00245
is: HMDB00251

metaM hexdiac c
name: hexadecanediocacid
constant: false
boundary condition: false
is: C08260
type: Species
is: HMDB00672
notes: FORMULA: C16H28O4 CHARGE: -2
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM 7dhchsterol c
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:17759
name: cholesta-5,7-dien-3beta-ol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
boundary condition: false
initial concentration: 1.0
is: HMDB00032

metaM hyptaur c
type: Species
is: SBO:0000247
name: Hypotaurine
constant: false
is: CHEBI:16668
is: HMDB00965
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_11cc7e2d_631e_4980_a240_a8b185020682
is: SBO:0000252
initial amount: NaN
type: Species
name: NDUFB1
is encoded by: hsa:4707
is: O75438
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false

metaM perillyl e
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
name: perillyl alcohol
notes: FORMULA: C10H16O CHARGE: 0 INCHI: InChI=1S/C10H16O/c1-8(2)10-5-3-9(7-11)4-6-10/h3,10-11H,1,4-7H2,2H3 EHMN_ABBREVIATION: C02452
is: HMDB03634
is: CHEBI:15420
constant: false
boundary condition: false

metaM xu1p D c
type: Species
initial amount: NaN
is: HMDB06534
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: D-Xylulose 1-phosphate
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h3,5-7,9H,1-2H2,(H2,10,11,12)/t3-,5-/m1/s1
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_f7439f55_a645_4022_a495_3c3d10eba1d8
name: SCP2
constant: false
is encoded by: hsa:6342
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is: C9JC79

http://identifiers.org/biomodels.db/MODEL1310110012#_118333e6_0308_4dc7_91d6_cc65dabc5ae0
is: Q53HE2
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:7167
name: TPI1
is: SBO:0000252
initial concentration: NaN
type: Species

metaR r2082
modifier: MODEL1310110012#
product: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

metaR r1431
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
product: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1

http://identifiers.org/biomodels.db/MODEL1310110012#_e42f5512_2827_44c6_8aea_6ed9b9a80751
is encoded by: hsa:8622
is: O95263
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: PDE8B

metaR FAS140COA
is: SBO:0000176
kinetic law: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
modifier: MODEL1310110012#
is described by: ECO:0000269
reversible: false
name: fatty-acyl-CoA synthase (n-C14:0CoA)
fast: false
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.85

metaM h e
type: Species
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: "
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
initial concentration: 1.0
boundary condition: false
constant: false
name: proton
is: C00080

metaR OAGD3te
is: SBO:0000185
name: oagd3 hs transport
reactant: MODEL1310110012#
is described by: ECO:0000000
fast: false
product: MODEL1310110012#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
kinetic law: MODEL1310110012#

metaM 3dodtricoa x
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
is: HMDB11123
boundary condition: false
initial amount: NaN
name: 3,6,9-dodecatrienoylcoa
is: C05279
constant: false

metaM c8crn c
initial amount: NaN
notes: FORMULA: C15H29NO4 CHARGE: 0
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB00791
is: C02838
initial concentration: 1.0
name: octanoyl carnitine
constant: false
has only substance units: false

metaM tmndnccoa m
boundary condition: false
initial concentration: 1.0
name: timnodonyl coenzyme A
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB06514
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_d58b263c_e7af_4888_9d5b_b3c7b9dca1e3
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: PNP
is: SBO:0000252
is: P00491
type: Species
has only substance units: false
constant: false
is encoded by: hsa:4860

metaR C4STMO2Pr
type: Reaction
reversible: false
name: C-4 methyl sterol oxidase
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.1.1.170
is described by: ECO:0000000
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#
fast: false

metaM nadph c
is: HMDB00221
has only substance units: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: CHEBI:57783
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: C00005
constant: false
initial amount: NaN

metaR ASNtm
is described by: ECO:0000000
type: Reaction
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
reversible: false
reactant: MODEL1310110012#
is: SBO:0000185
name: L-asparagine transport, mitochondrial
fast: false
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_a1602b76_d1b1_4885_bec2_89d12d8a1eca
initial amount: NaN
is encoded by: hsa:5286
boundary condition: true
is: O00443
has only substance units: false
name: PIK3C2A
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species

metaR r2083
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110012#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000185
reversible: true
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR FAOXC5OHc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: (3-hydroxyisovalerylcoa-->3-hydroxyisovalerylcarnitine)c
type: Reaction

metaR GLYt7 311 r
type: Reaction
product: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: glycine reversible transport via sodium and chloride symport (3:1:1)
kinetic law: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
is: SBO:0000185
reversible: true
is described by: ECO:0000006

metaM ksi deg3 l
is: SBO:0000247
has only substance units: false
is: HMDB00573
constant: false
name: keratan sulfate I, degradation product 3
initial concentration: 1.0
is: CHEBI:30825
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C233H371N16O205S12 CHARGE: -13

http://identifiers.org/biomodels.db/MODEL1310110012#_fc7d03b6_bba9_4f2f_9102_e1a04f76e0d7
has part: B4DY56
has only substance units: false
boundary condition: true
initial concentration: NaN
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
initial amount: NaN
is encoded by: hsa:498
type: Species
is: SBO:0000297
constant: false

metaM thcholstoic x
is: SBO:0000247
type: Species
is: CHEBI:18402
is: HMDB03873
initial amount: NaN
constant: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
has only substance units: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_21153285_535f_48cf_9ad7_87fe1ea95e07
is encoded by: hsa:223
constant: false
is: P49189
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: ALDH9A1
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_970a27e0_e3d5_44ff_b12f_a44bae87e7ad
type: Species
is: SBO:0000252
name: HKDC1
boundary condition: true
has only substance units: false
is encoded by: hsa:80201
initial amount: NaN
is: B3KT70
initial concentration: NaN
constant: false

metaR r0596
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
is: SBO:0000176
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
fast: false
product: MODEL1310110012#

metaM ump e
is: CHEBI:57865
initial concentration: 1.0
is: HMDB00288
boundary condition: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
has only substance units: false
type: Species
name: UMP(2-)
is: SBO:0000247
constant: false
initial amount: NaN

metaR FAOXC180
is: SBO:0000176
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
reactant: MODEL1310110012#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
name: Beta oxidation of long chain fatty acid
type: Reaction
product: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110012#_d1398376_ba7f_4d4e_9033_a9bec8ab5653
name: ACAD9
type: Species
is: SBO:0000252
is: Q9H845
initial amount: NaN
is encoded by: hsa:28976
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false

metaR RTOTAL2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
reversible: true
fast: false
is: SBO:0000185
name: RTOTAL2 transport
kinetic law: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110012#
product: MODEL1310110012#

metaR RE1898C
is: SBO:0000176
name: RE1898
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
reactant: MODEL1310110012#
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

metaM succ e
name: succinate(2-)
has only substance units: false
is: CHEBI:30031
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
initial amount: NaN
is: HMDB00254

metaR APOCFm
is described by: ECO:0000000
reactant: MODEL1310110012#
name: Apocarboxylase formation, mitochondrial
product: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
type: Reaction
reversible: false

metaR FAOXC5C5DCc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of glutaryl carnitine
type: Reaction

metaR S3TASE2ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
reactant: MODEL1310110012#
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110012#
reversible: true
name: N-acetylglucosamine-3-sulfatase, lysosomal
product: MODEL1310110012#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110012#_bd95c7b2_09fa_4dd6_b97e_0e80c91e4851
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is: Q9Y2Q0
is encoded by: hsa:10396
has only substance units: false
name: ATP8A1

metaM hs deg16 l
boundary condition: false
has only substance units: false
name: heparan sulfate, degradation product 16
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
is: CHEBI:21338
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB02704
initial concentration: 1.0

metaR ATPS4m
name: ATP synthase (four protons for one ATP)
is version of: http://identifiers.org/ec-code/3.6.1.14
notes: GENE_ASSOCIATION: (513.1 and 498.2 and 506.1 and 509.2 and 514.1 or 498.2 and 513.2 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 514.2 and 506.1 or 498.2 and 513.2 and 506.1 and 509.2 and 514.1 or 513.2 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 498.1 and 506.1 and 509.2 and 514.1 or 513.1 and 498.2 and 514.2 and 506.1 and 509.2 or 513.1 and 498.2 and 509.1 and 506.1 and 514.1 or 498.2 and 509.1 and 513.2 and 506.1 and 514.1 or 513.2 and 498.1 and 506.1 and 509.2 and 514.1 or 513.2 and 514.2 and 506.1 and 509.2 and 498.3 or 513.2 and 506.1 and 509.2 and 498.3 and 514.1 or 513.1 and 509.1 and 506.1 and 498.3 and 514.1 or 509.1 and 513.2 and 514.2 and 506.1 and 498.3 or 513.1 and 498.2 and 509.1 and 514.2 and 506.1 or 513.1 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 506.1 and 514.1 or 513.1 and 506.1 and 509.2 and 498.3 and 514.1 or 509.1 and 513.2 and 506.1 and 498.3 and 514.1 or 513.1 and 514.2 and 506.1 and 509.2 and 498.3 or 509.1 and 513.2 and 498.1 and 506.1 and 514.1 or 513.1 and 509.1 and 514.2 and 506.1 and 498.3 or 498.2 and 509.1 and 513.2 and 514.2 and 506.1 or 509.1 and 513.2 and 498.1 and 514.2 and 506.1) and (10632.1 and 4905.1 and 10476.1 and 9551.3 and 522.5 and 516.2 and 521.1 and 515.1 or 518.3 and 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 9551.3 and 522.3 or 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 517.2 and 9551.2 and 522.3 or 10632.1 and 4905.1 and 10476.1 and 522.5 and 9551.2 and 518.2 and 521.1 and 515.1 or 4905.1 and 515.2 and 10476.2 and 516.2 and 521.1 and 10632.1 and 9551.3 and 522.5 or 518.3 and 4905.1 and 9551.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 522.4 or 10632.1 and 4905.1 and 10476.1 and 9551.1 and 522.2 and 515.2 and 518.2 and 521.1 or 518.3 and 10632.1 and 4905.1 and 10476.1 and 515.3 and 9551.2 and 522.4 and 521.1 or 10632.1 and 4905.1 and 10476.1 and 515.3 and 522.2 and 9551.3 and 518.2 and 521.1 or 4905.1 and 9551.1 and 10476.2 and 522…
type: Reaction
is described by: ECO:0000134
product: MODEL1310110012#
is: SBO:0000185
modifier: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
reversible: false
is version of: http://identifiers.org/ec-code/3.6.3.14
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.6.4.6

metaR r0381
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
fast: false
kinetic law: MODEL1310110012#
type: Reaction
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110012#
is: SBO:0000176

metaM adrnl c
initial amount: NaN
boundary condition: false
is: HMDB00068
is: CHEBI:33568
type: Species
constant: false
is: SBO:0000247
has only substance units: false
name: Adrenaline
initial concentration: 1.0
notes: FORMULA: C9H14NO3 CHARGE: 1 INCHI: InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3 EHMN_ABBREVIATION: C00788

http://identifiers.org/biomodels.db/MODEL1310110012#_26cb2091_067e_470f_b62d_c7ba8aae3405
boundary condition: true
initial concentration: NaN
name: SLC5A1
constant: false
is encoded by: hsa:6523
is: P13866
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110012#_383a58dc_ee75_4be1_b37f_ac6fad999fe9
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is: B4E3E9
name: OGDH
initial concentration: NaN
constant: false
is encoded by: hsa:4967

http://identifiers.org/biomodels.db/MODEL1310110012#_bb0d3eaa_7404_4b4e_a91d_383be93b5ca7
is: P52789
boundary condition: true
type: Species
is encoded by: hsa:3099
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: HK2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_7a102979_f00e_45b3_a13d_2b92b192620e
constant: false
has only substance units: false
name: NMNAT2
is: Q9BZQ4
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:23057
type: Species

metaR DHCRD1
reversible: false
is: SBO:0000176
name: dihydroceramide desaturase
kinetic law: MODEL1310110012#
product: MODEL1310110012#
modifier: MODEL1310110012#
fast: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110012#_64bfc090_153c_417d_84f3_f6106722f41a
type: Species
is: SBO:0000252
constant: false
is: P32119
initial concentration: NaN
initial amount: NaN
name: PRDX2
has only substance units: false
is encoded by: hsa:7001
boundary condition: true

metaM n2m2nmasn l
notes: FORMULA: C58H96N5O40X CHARGE: 0
type: Species
initial concentration: 1.0
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: C04946
boundary condition: false
constant: false

metaR ALAt2r
name: L-alanine reversible transport via proton symport
modifier: MODEL1310110012#
is: SBO:0000185
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
product: MODEL1310110012#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000304

metaR GGLUCT
is: SBO:0000185
modifier: MODEL1310110012#
reversible: false
name: gamma-glutamylcyclotransferase
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.2.4
product: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110012#_9918dc50_e5d6_4500_b029_038aa12e934f
constant: false
name: EHHADH
initial amount: NaN
is: Q9NY65
is encoded by: hsa:1962
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaR r1546
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110012#
product: MODEL1310110012#
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_d42c15c6_6e98_4cc1_afb0_8afa2a20d7af
initial concentration: NaN
is: P15121
is encoded by: hsa:231
initial amount: NaN
type: Species
boundary condition: true
name: AKR1B1
has only substance units: false
constant: false
is: SBO:0000252

metaR ETFQO
product: MODEL1310110012#
is described by: ECO:0000000
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
type: Reaction
fast: false
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
reactant: MODEL1310110012#
reversible: false
is version of: http://identifiers.org/ec-code/1.5.5.1

metaM 4abutn c
constant: false
is: SBO:0000247
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
name: 4-Aminobutanal
is: CHEBI:58264
is: C00555
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: HMDB01080
has only substance units: false

metaM ump c
initial concentration: 1.0
is: CHEBI:57865
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00288
type: Species
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: C00105
is: SBO:0000247
constant: false
name: UMP

metaM cs b deg1 l
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00812
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
is: CHEBI:16953
type: Species

metaR ILETAm
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
type: Reaction
name: isoleucine transaminase, mitochondrial
is: SBO:0000176
reactant: MODEL1310110012#
modifier: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000269
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reversible: true

metaR r0594
reversible: true
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000000
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
is: SBO:0000176
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
product: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:

metaM cbasp e
is: HMDB00828
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:32814
name: N-Carbamoyl-L-aspartate
is: SBO:0000247
is: C00438
notes: FORMULA: C5H6N2O5 CHARGE: -2
constant: false

metaM HC01459 x
is: CHEBI:27458
initial amount: NaN
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_3e98b7f3_0eaa_41bf_80ff_e24da223153e
name: RPL36A
is encoded by: hsa:6173
constant: false
initial concentration: NaN
is: SBO:0000252
is: P83881
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false

metaM CE2422 m
initial amount: NaN
boundary condition: false
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
constant: false
is: SBO:0000247
is: CHEBI:28387
is: HMDB11123
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
type: Species
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_5901a3e6_4c75_41a8_bc03_84b03ad53ec0
is: A8MYF6
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:6307
is: SBO:0000252
type: Species
initial concentration: NaN
name: MSMO1
initial amount: NaN

metaR r1547
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110012#
reversible: true
fast: false
reactant: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR RE3006M
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110012#
type: Reaction
fast: false
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110012#
name: RE3006
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR 41R2A1H12BOOX
is: SBO:0000176
reactant: MODEL1310110012#
reversible: false
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.4.3.4
product: MODEL1310110012#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110012#
fast: false
name: 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
modifier: MODEL1310110012#

metaR ALAASNNaEx
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000269
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110012#
reversible: false
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)
product: MODEL1310110012#

metaR ACONTm
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.3
modifier: MODEL1310110012#
reactant: MODEL1310110012#
name: Aconitate hydratase

http://identifiers.org/biomodels.db/MODEL1310110012#_9054293f_2bdf_4ba3_9b2c_ce7e4608fa35
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: HADHA
is encoded by: hsa:3030
constant: false
initial amount: NaN
is: E9KL44
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_ed91b6d3_145a_4083_9fc4_1224c8427655
name: HEPH
boundary condition: true
is encoded by: hsa:9843
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: E9PHN8
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_c686df47_6442_4b2e_9203_a0efaef79811
boundary condition: true
type: Species
name: ENTPD2
has only substance units: false
initial amount: NaN
is: Q5SPY7
constant: false
initial concentration: NaN
is encoded by: hsa:954
is: SBO:0000252

metaM 2dr5p c
is: CHEBI:57651
initial amount: NaN
name: 2-deoxy-D-ribose 5-phosphate(2-)
initial concentration: 1.0
is: HMDB01031
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673

http://identifiers.org/biomodels.db/MODEL1310110012#_eeaabb92_0e88_4ebb_ab04_476e9d9da025
constant: false
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q674R7
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:285973
name: ATG9B

http://identifiers.org/biomodels.db/MODEL1310110012#_62f5e214_dcbc_453a_948e_d66d868218b9
is encoded by: hsa:64600
has only substance units: false
is: SBO:0000252
is: Q9BZM2
initial amount: NaN
boundary condition: true
type: Species
constant: false
name: PLA2G2F
initial concentration: NaN

metaR EX glygn4 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaR VALt5m
name: Valine reversible mitochondrial transport
is: SBO:0000185
product: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110012#

metaR S3TASE1ly
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000000
name: N-acetylglucosamine-3-sulfatase, lysosomal

metaR CERT2gt
type: Reaction
reversible: true
product: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
modifier: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
is described by: ECO:0000000
name: ceramide transport protein
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.7.11.1

http://identifiers.org/biomodels.db/MODEL1310110012#_a600f18c_5e6d_47f1_8a30_5735931a1767
initial amount: NaN
is: SBO:0000297
has only substance units: false
constant: false
is encoded by: hsa:5295
name: PIK3CD:PIK3R1
boundary condition: true
initial concentration: NaN
type: Species
has part: E7EX19

metaM 3deccrn e
is: HMDB02250
type: Species
name: 3-hydroxydecanoylcarnitine
boundary condition: false
initial amount: NaN
notes: FORMULA: C17H33NO5 CHARGE: 0
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_cbf530e7_07b6_4195_b425_8f1dad35858c
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: P04180
constant: false
type: Species
name: LCAT
is encoded by: hsa:3931

metaR r1548
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reversible: true
reactant: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000

metaR TALA
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
is: SBO:0000176
fast: false
reversible: true
name: transaldolase
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.2.1.2
reactant: MODEL1310110012#
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#

metaR CYTK14
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000269
fast: false
reversible: true
product: MODEL1310110012#
name: cytidylate kinase (dCMP,UTP)
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110012#

metaR P45027A11m
product: MODEL1310110012#
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
is described by: ECO:0000269
reactant: MODEL1310110012#
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ

metaM m8mpdol U r
type: Species
notes: FORMULA: C1725H2840N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:59093

metaR C12DCTD
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Dodecanedioic acid by diffusion
type: Reaction

metaM fadh2 r
type: Species
is: CHEBI:58307
has only substance units: false
name: FADH2(2-)
initial amount: NaN
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
constant: false
is: SBO:0000247
is: HMDB01197
boundary condition: false
initial concentration: 1.0

metaR FAOXC184C164x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)x
type: Reaction

metaR r1549
reversible: true
kinetic law: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110012#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
type: Reaction

metaR D3AIBTm
product: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000176
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110012#_f450e775_34e3_4557_bf9a_2594fd73a0ff
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:3032
has only substance units: false
initial amount: NaN
name: HADHB
initial concentration: NaN
is: P55084

http://identifiers.org/biomodels.db/MODEL1310110012#_881603ba_d2fe_49c6_881d_b07c594f1ad9
has only substance units: false
is encoded by: hsa:56901
constant: false
initial amount: NaN
is: Q9NRX3
name: NDUFA4L2
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_0b8fc361_b130_43a9_b619_0e7add0f49de
initial amount: NaN
is: O43677
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
name: NDUFC1
constant: false
is encoded by: hsa:4717

metaM ahcys e
is: C00021
is: HMDB00939
boundary condition: false
name: S-Adenosyl-L-homocysteine
is: SBO:0000247
notes: FORMULA: C14H20N6O5S CHARGE: 0
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16680
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_97a86e2b_7a2c_4a55_bbd6_c669ce916e5a
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
name: _AI091231_1_c
is encoded by: hsa:AI091231
type: Species

metaR ILETA
name: isoleucine transaminase
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
product: MODEL1310110012#
fast: false
modifier: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
is described by: ECO:0000269

metaR DPPS
is described by: ECO:0000134
product: MODEL1310110012#
reactant: MODEL1310110012#
name: decaprenyl synthase
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 2 AUTHORS: PMID:16262699 NOTES:by analogy to other dimethyl transferase rxns. See PMID: 10586494, human interemidate (from C15 ->C50) not explicitly determined yet, however it is known to occur since this pathway is essential in Q10 synthesis. For human metabolism: may be associated w/ GeneID: 23590 TPRT - recheck lit in future IT and NJ
type: Reaction
reversible: false
kinetic law: MODEL1310110012#
is: SBO:0000176

metaM dece3coa x
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
name: 3-decenoylcoa
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN

metaR P4502C93
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (1559.1) or (1557.1) SUBSYSTEM: Limonene and pinene degradation EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:11950794,PMID:11996015 NOTES:assumed to take place on outer membrane NJ
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
name: cytochrome P450 2C9
product: MODEL1310110012#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.13.48
fast: false
is: SBO:0000176
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_1be6bb9e_590e_49ee_841c_469bb906b140
type: Species
name: SLC5A11
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q8WWX8
is encoded by: hsa:115584
constant: false
has only substance units: false

metaM c101crn e
constant: false
is: SBO:0000247
notes: FORMULA: C17H31NO4 CHARGE: 0
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB13205
name: decenoyl carnitine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_3c6ee85b_2dfa_4570_bc2d_9c939dbc4d24
name: DLD:DLST:OGDH:PDHX
has part: P09622
has part: O00330
is encoded by: hsa:1743
has part: Q02218
is: SBO:0000297
boundary condition: true
has part: P36957
is encoded by: hsa:4967
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:8050
is encoded by: hsa:1738

metaR C162OHc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxy hexadecadienoyl carnitine
type: Reaction

metaR RE3628M
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110012#
name: RE3628
type: Reaction
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/5.3.3.8
is described by: ECO:0000000
product: MODEL1310110012#
reversible: true

metaR G13MT U
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
name: Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)
is: SBO:0000176
reversible: false
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.132
fast: false
reactant: MODEL1310110012#

metaR MI34PP
modifier: MODEL1310110012#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
name: inositol-3,4-bisphosphate 4-phosphatase
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.66
notes: GENE_ASSOCIATION: (3631.2) or (3631.1) or (8821.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:7608176,PMID:9295334 NOTES:NCD
product: MODEL1310110012#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110012#_d3b8ac5e_096f_4f52_830a_03c87ed320e1
is: P08195
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6520
initial concentration: NaN
name: SLC3A2
constant: false
type: Species
initial amount: NaN

metaM thcholstoic r
is: CHEBI:18402
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: SBO:0000247
is: HMDB03873
type: Species
boundary condition: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_f96d553f_999a_43d9_9f41_d60df6745b64
is: P47712
has only substance units: false
type: Species
initial concentration: NaN
constant: false
name: PLA2G4A
is: SBO:0000252
is encoded by: hsa:5321
boundary condition: true
initial amount: NaN

metaM 6thf e
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
constant: false
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
is: http://identifiers.org/pubchem.compound/169691
name: hexaglutamyl folate (THF)
initial concentration: 1.0
initial amount: NaN

metaR GLUDym
is: SBO:0000176
product: MODEL1310110012#
modifier: MODEL1310110012#
reversible: true
reactant: MODEL1310110012#
name: glutamate dehydrogenase (NADP), mitochondrial
type: Reaction
fast: false
kinetic law: MODEL1310110012#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.1.3
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110012#_0d4de2c2_5d18_4f00_abac_dc4c06db92fa
is encoded by: hsa:29880
boundary condition: true
is: Q9Y673
type: Species
name: ALG5
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR r0170
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
fast: false
kinetic law: MODEL1310110012#
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.40
modifier: MODEL1310110012#
reversible: true
product: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_6db77267_0294_4864_b60a_73fb78aa4abf
initial concentration: NaN
type: Species
name: CPT1A
initial amount: NaN
has only substance units: false
is: Q8WZ48
is: SBO:0000252
constant: false
is encoded by: hsa:1374
boundary condition: true

metaM hedepecoa m
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB02288
initial concentration: 1.0
initial amount: NaN
name: 2,4,7,10,13-hexadecapentenoylcoa
type: Species
has only substance units: false
notes: FORMULA: C37H52N7O17P3S CHARGE: -4

metaR r0497
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
modifier: MODEL1310110012#
reversible: true
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000176
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.2.4.2

metaM succ c
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: SBO:0000247
initial concentration: 1.0
is: HMDB00254
boundary condition: false
constant: false
is: CHEBI:30031
name: Succinate
has only substance units: false
type: Species
is: C00042
initial amount: NaN

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR P4502C94
reversible: false
is: SBO:0000176
reactant: MODEL1310110012#
name: cytochrome P450 2C9
kinetic law: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.13.48
fast: false
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (1559.1) or (1557.1) SUBSYSTEM: Limonene and pinene degradation EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:11950794,PMID:11996015 NOTES:assumed to take place on outer membrane NJ

http://identifiers.org/biomodels.db/MODEL1310110012#_1b67b849_1cf4_46e9_84f6_90966b1cced5
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: P07101
is: SBO:0000252
boundary condition: true
name: TH
is encoded by: hsa:7054

metaR r0384
reversible: false
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
type: Reaction
product: MODEL1310110012#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110012#
is: SBO:0000176
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:

metaR ACSm
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 6.2.1.1 Confidence Level: 2 AUTHORS: PMID:11150295,PMID:4326157 NOTES:IF
modifier: MODEL1310110012#
is described by: ECO:0000304
kinetic law: MODEL1310110012#
reversible: false
name: acetyl-CoA synthetase
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.1
is: SBO:0000176
product: MODEL1310110012#
reactant: MODEL1310110012#
fast: false

metaM 2dodtricoa x
has only substance units: false
constant: false
initial amount: NaN
is: HMDB11123
is: SBO:0000247
type: Species
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
name: 2,6,9-dodecatrienoylcoa
is: C05279

http://identifiers.org/biomodels.db/MODEL1310110012#_be762a96_9f1a_4388_89b7_b39f022c898e
is: P82251
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:11136
type: Species
initial amount: NaN
name: SLC7A9

metaR ABO9g
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000176
fast: false
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
is version of: http://identifiers.org/ec-code/2.4.1.37
product: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
type: Reaction
is described by: ECO:0000269
reversible: false

metaR NACHEX26ly
fast: false
is: SBO:0000176
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110012#
is described by: ECO:0000000
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110012#_7301893a_9910_446b_b21a_1ee3a4ffebec
initial concentration: NaN
is: Q9C0J1
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:79369
name: B3GNT4
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_a81ac591_4c0a_4dea_ad7d_bb0e751e58fa
has only substance units: false
name: DBT
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:1629
is: P11182
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_e9251944_a5cd_4035_ae6e_1af30f653cdc
type: Species
has only substance units: false
initial amount: NaN
is: C9JZ62
boundary condition: true
is: SBO:0000252
is encoded by: hsa:641649
initial concentration: NaN
constant: false
name: TMEM91

metaM so3 m
has only substance units: false
name: hydrogensulfite
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: CHEBI:17137
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB00240
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_678eac80_2a9c_4ee2_bb4f_d3b3bb74890d
name: CROT
is: SBO:0000252
is: E7EQF2
boundary condition: true
type: Species
constant: false
is encoded by: hsa:54677
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_8e909f7d_c812_487f_846c_c2cd3a5c20e5
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: F5H2Y9
is encoded by: hsa:8854
is: SBO:0000252
name: ALDH1A2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_410e70b1_2e49_40c1_95f6_0edcd9b17742
name: FASN
constant: false
is: P49327
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:2194
initial concentration: NaN
is: SBO:0000252

metaM c101crn c
notes: FORMULA: C17H31NO4 CHARGE: 0
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
name: decenoyl carnitine
initial amount: NaN
is: HMDB13205
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_afd56ce5_384b_4859_ac78_c5d43a95e597
is: Q546E0
is encoded by: hsa:2530
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: FUT8
constant: false

metaR C162OHe
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C16:2OH
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_0fa67095_6dad_4533_ac34_66cd4a1f58b3
is encoded by: hsa:8611
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
is: G3XA95
initial concentration: NaN
has only substance units: false
boundary condition: true
name: PPAP2A

metaR PNTK
reversible: false
product: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.33
is: SBO:0000176
reactant: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
name: pantothenate kinase
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269

metaR PI45PLC
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
product: MODEL1310110012#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
type: Reaction
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.1.4.11

http://identifiers.org/biomodels.db/MODEL1310110012#_db7120b9_20da_4908_907f_4b84d8c067f4
constant: false
type: Species
initial concentration: NaN
name: ACOT2
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10965
is: P49753
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_d63d2acf_bcfd_4eee_8162_6f1dfc9cd26a
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: O75891
is: SBO:0000252
name: ALDH1L1
is encoded by: hsa:10840

http://identifiers.org/biomodels.db/MODEL1310110012#_b5256916_007d_47b4_bb00_7ddce0ac53af
constant: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:1103
has only substance units: false
name: CHAT
initial concentration: NaN
is: SBO:0000252
is: D3DX95

metaM C04849 e
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
boundary condition: false
is: CHEBI:57449
has only substance units: false
initial concentration: 1.0
type: Species

metaM ahcys c
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:16680
type: Species
is: HMDB00939
initial amount: NaN
name: S-Adenosyl-L-homocysteine
constant: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
boundary condition: false
is: C00021

metaR ACACT1x
reactant: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
modifier: MODEL1310110012#
name: acetyl-CoA C-acetyltransferase, mitochondrial
product: MODEL1310110012#
fast: false
is: SBO:0000176
reversible: false
is described by: ECO:0000134
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.9

http://identifiers.org/biomodels.db/MODEL1310110012#_8ba0f0f0_c825_4174_a284_fc1380a60066
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1809
name: DPYSL3
constant: false
is: Q8IXW6
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR DDCRNe
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydodecanoyl carnitine into extra cellular space
type: Reaction

metaM succ m
is: CHEBI:30031
boundary condition: false
is: HMDB00254
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: C00042
has only substance units: false
is: SBO:0000247
name: Succinate
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042

metaR FMNAT
product: MODEL1310110012#
is described by: ECO:0000134
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
type: Reaction
modifier: MODEL1310110012#
name: FMN adenylyltransferase
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.2
fast: false
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_3a7e482d_03c3_4a4d_86f9_2481b694a086
constant: false
boundary condition: true
is: P51857
is: SBO:0000252
is encoded by: hsa:6718
type: Species
has only substance units: false
initial concentration: NaN
name: AKR1D1
initial amount: NaN

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaR CYSO
type: Reaction
modifier: MODEL1310110012#
reactant: MODEL1310110012#
product: MODEL1310110012#
name: cysteine oxidase
fast: false
reversible: false
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.20
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT

metaR r1658
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
reversible: true
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110012#_a6b18732_9309_4bae_92f8_bfe5ba968b89
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: SLC5A2
is: P31639
initial concentration: NaN
is encoded by: hsa:6524
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_9e38ee71_4c9f_4c67_980e_dbb8cc8b0067
constant: false
is: Q8TBG4
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
name: AGXT2L1
has only substance units: false
is encoded by: hsa:64850

http://identifiers.org/biomodels.db/MODEL1310110012#_ae2fe1b7_33e5_4a93_834f_fc418ec2c6f6
initial amount: NaN
name: AK2
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:204
boundary condition: true
type: Species
initial concentration: NaN

metaM ksii core2 deg8 l
notes: FORMULA: C36H60N3O25X CHARGE: 0
is: SBO:0000247
is: CHEBI:12936
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00143
name: keratan sulfate II (core 2-linked), degradation product 8
has only substance units: false
constant: false
boundary condition: false

metaM fald e
type: Species
is: CHEBI:16842
has only substance units: false
constant: false
is: HMDB01426
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: formaldehyde
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_9f8b1d76_2de4_439f_9f87_ddf50f7cd83a
type: Species
boundary condition: true
is: SBO:0000252
constant: false
name: UGP2
is encoded by: hsa:7360
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR r0281
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/5.3.1.6
kinetic law: MODEL1310110012#
reversible: true
is: SBO:0000176
product: MODEL1310110012#
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
reactant: MODEL1310110012#

metaM n2m2nmasn e
is: SBO:0000247
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
boundary condition: false
constant: false
type: Species
notes: FORMULA: C58H96N5O40X CHARGE: 0
initial amount: NaN
is: C04946
initial concentration: 1.0
has only substance units: false

metaM tmndnccrn m
boundary condition: false
is: CHEBI:16987
type: Species
name: Timnodonyl carnitine
notes: FORMULA: C27H43NO4 CHARGE: 0 INCHI: InChI=1/C28H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-28(32)33-26(24-27(30)31)25-29(2,3)4/h6-7,9-10,12-13,15-16,18-19,26H,5,8,11,14,17,20-25H2,1-4H3/t26-/m0/s1
is: HMDB12130
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR FAOXC184C164m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)m
type: Reaction

metaR AMPTASECG
is: SBO:0000176
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
name: alanyl aminopeptidase (cys-gly)
is described by: ECO:0000212
product: MODEL1310110012#
type: Reaction
reversible: false
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (290.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.1 Confidence Level: 1 AUTHORS: PMID:12675513 NOTES:SAB. activity measured in cytosol rat liver; IT IS leucine aminopeptidase (EC3.4.11.1) NOT alanyl aminopeptidase EC3.4.11.2 which shows > 80% of the activity; sequence homology rat-human not yet verified; annotation 'extracellular' under B column ERROR
is version of: http://identifiers.org/ec-code/3.4.11.2

http://identifiers.org/biomodels.db/MODEL1310110012#_32872242_2cd0_4c70_8937_a86638fcfeed
is encoded by: hsa:3177
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is: Q14542
initial amount: NaN
boundary condition: true
name: SLC29A2

metaM ksi pre14 g
name: keratan sulfate I biosynthesis, precursor 14
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
is: CHEBI:28067
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species

metaR r0389
fast: false
product: MODEL1310110012#
name: Pyridoxine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.1.3.12
is described by: ECO:0000000
reactant: MODEL1310110012#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.1.3.12 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
kinetic law: MODEL1310110012#
type: Reaction

metaR r1659
is: SBO:0000185
reversible: true
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaM dgtp n
is: HMDB01440
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
constant: false
name: dGTP
is: C00286
has only substance units: false
is: CHEBI:16497

metaR BHBt
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction
product: MODEL1310110012#
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
reactant: MODEL1310110012#
is: SBO:0000185

metaR r0494
product: MODEL1310110012#
is described by: ECO:0000000
fast: false
is: SBO:0000176
kinetic law: MODEL1310110012#
reversible: true
reactant: MODEL1310110012#
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

metaR LINOFATPtc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_0a562afc_8cbf_44a3_a730_e8b033d574cb
initial amount: NaN
constant: false
is encoded by: hsa:AI697028
initial concentration: NaN
name: _AI697028_1_m
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaR r0280
fast: false
kinetic law: MODEL1310110012#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110012#
modifier: MODEL1310110012#
reactant: MODEL1310110012#
name: dATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:

metaM urea c
name: Urea
type: Species
is: HMDB00294
is: C00086
is: SBO:0000247
constant: false
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:16199

metaM fadh2 m
is: CHEBI:58307
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB01197
initial amount: NaN
has only substance units: false
name: Flavin adenine dinucleotide reduced
type: Species
is: C01352
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352

metaR C181CPT2
fast: false
modifier: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000176
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV
type: Reaction
name: transport of Octadecenoyl-CoA into mitochondrial matrix
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110012#_27901005_0137_4c8a_b91a_476ae87b3e42
is: P21589
boundary condition: true
initial amount: NaN
name: NT5E
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:4907
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_efd19209_0560_4e60_8382_fca464a9c64c
is: SBO:0000252
type: Species
initial concentration: NaN
is: P07451
name: CA3
has only substance units: false
initial amount: NaN
is encoded by: hsa:761
boundary condition: true
constant: false

metaM asp L e
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
constant: false
initial concentration: 1.0
is: CHEBI:29991
is: HMDB00191
name: L-aspartate(1-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_b84d28d4_bde2_44a4_a900_c14fd10e4191
is encoded by: hsa:5330
has only substance units: false
name: PLCB2
initial concentration: NaN
initial amount: NaN
is: Q59F77
constant: false
is: SBO:0000252
type: Species
boundary condition: true

metaR EX 3deccrn
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydecanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_5ac88189_1e59_472d_ab92_615f1e6b9fe4
is: Q9HCQ5
constant: false
has only substance units: false
is encoded by: hsa:50614
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: GALNT9

metaM udpgal g
is: SBO:0000247
type: Species
is: HMDB00302
has only substance units: false
name: UDP-D-galactose(2-)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
constant: false
is: CHEBI:58439
initial amount: NaN

metaR r0388
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
is: SBO:0000176
fast: false
name: Pyridoxamine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.4.3.5
product: MODEL1310110012#

metaR EX htaxol LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hydroxylated taxol exchange
type: Reaction

metaM fald c
type: Species
is: CHEBI:16842
initial concentration: 1.0
name: formaldehyde
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
constant: false
is: HMDB01426
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR GCNTg
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2651.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.150 Confidence Level: 4 AUTHORS: PMID:15161861,PMID:8449405 NOTES:NJ
modifier: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.4.1.150
name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
reversible: false
kinetic law: MODEL1310110012#

metaR AHEXASEly
reversible: false
fast: false
type: Reaction
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000176
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110012#_e150ad15_17bc_435b_a41d_b41272d14728
is: Q49AT3
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: B3GALNT1
boundary condition: true
is encoded by: hsa:8706
constant: false
has only substance units: false
type: Species

metaM itp c
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
boundary condition: false
type: Species
name: ITP(3-)
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:57614
initial amount: NaN
initial concentration: 1.0
is: HMDB00189

metaR EX 34dhoxpeg LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxyphenylethyleneglycol exchange
type: Reaction

metaM HC01444 e
constant: false
type: Species
initial amount: NaN
name: Galactosylglycerol
initial concentration: 1.0
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
is: CHEBI:15754
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR G12MT2 U
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110012#
reactant: MODEL1310110012#
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
kinetic law: MODEL1310110012#
fast: false
is described by: ECO:0000000
is: SBO:0000176

metaR UREAt
modifier: MODEL1310110012#
product: MODEL1310110012#
kinetic law: MODEL1310110012#
name: Urea transport via facilitate diffusion
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6523.1) or (6563.1) or (6528.1) or (8170.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:12856182,PMID:2490366,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:JLR
is: SBO:0000185
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110012#

metaM itp e
name: ITP(3-)
type: Species
is: CHEBI:57614
constant: false
is: SBO:0000247
is: HMDB00189
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaM crn r
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: CHEBI:16347
initial amount: NaN
is: SBO:0000247
name: (R)-carnitine
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00062
type: Species

metaR 3HKYNAKGAT
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.6.1.7
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
type: Reaction
is: SBO:0000176
modifier: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.64
reversible: false
is described by: ECO:0000304
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_4793d880_e55a_47c0_ad4c_203da2ef7f59
name: HSD17B10
initial amount: NaN
is encoded by: hsa:3028
constant: false
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q99714
initial concentration: NaN

metaR C4OHc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxybytyryl carnitinec
type: Reaction

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaM taur x
is: HMDB00251
is: SBO:0000247
is: CHEBI:15891
type: Species
constant: false
name: taurine
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
has only substance units: false
boundary condition: false

metaM gua e
is: HMDB00132
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
constant: false
is: CHEBI:16235
is: SBO:0000247
boundary condition: false
name: guanine
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0

metaR AKR1D2
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.3.1.3
reactant: MODEL1310110012#
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
reversible: false
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
fast: false
product: MODEL1310110012#

metaM thcholoylcoa x
name: 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA
is: SBO:0000247
has only substance units: false
is: HMDB12456
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-8-9-30-36-31(12-15-48(29,30)6)47(5)14-11-28(56)19-27(47)20-33(36)58)7-10-32(57)26(2)45(63)79-18-17-50-35(59)13-16-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-34-39(74-76(64,65)66)38(60)44(73-34)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,26?,27+,28-,29-,30+,31+,32?,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
is: CHEBI:27403
initial concentration: 1.0
boundary condition: false

metaM 4h2oglt m
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:17742
is: HMDB02070
name: 4-hydroxy-2-oxoglutarate(2-)
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2

http://identifiers.org/biomodels.db/MODEL1310110012#_4b052a18_e92e_429b_a648_6bd2bf05e9b8
is: Q15111
initial concentration: NaN
is encoded by: hsa:5334
has only substance units: false
is: SBO:0000252
boundary condition: true
name: PLCL1
type: Species
constant: false
initial amount: NaN

metaR C8CRNe
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octanoyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_eed7aad5_9bf8_4450_98e0_4891d275798a
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:205
name: AK4
has only substance units: false

metaR PIACGT
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
name: phosphatidylinositol N-acetylglucosaminyltransferase
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.4.1.83
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.198
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110012#
is described by: ECO:0000000
modifier: MODEL1310110012#
product: MODEL1310110012#

metaM s2l2fn2m2masn e
initial concentration: 1.0
name: PA6
boundary condition: false
is: C00255
type: Species
is: HMDB00244
is: SBO:0000247
is: CHEBI:3554
constant: false
initial amount: NaN
notes: FORMULA: C90H145N6O65X CHARGE: -2
has only substance units: false

metaR r1654
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110012#
modifier: MODEL1310110012#
reactant: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110012#
reversible: true

metaM asp L c
initial concentration: 1.0
type: Species
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial amount: NaN
name: L-aspartate(1-)
constant: false
is: CHEBI:29991
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00191

metaR GK1
is described by: ECO:0000269
name: guanylate kinase (GMP:ATP)
type: Reaction
fast: false
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.8
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_26fd2330_fe7d_4133_9c99_8a902ae7e92e
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is: B4E097
has only substance units: false
name: GALT
is encoded by: hsa:2592
initial amount: NaN

metaM prpp c
boundary condition: false
is: CHEBI:58017
is: SBO:0000247
type: Species
name: 5-Phospho-alpha-D-ribose 1-diphosphate
initial concentration: 1.0
is: HMDB00280
constant: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
has only substance units: false
initial amount: NaN
is: C00119

metaM CE5867 e
is: CHEBI:27485
initial amount: NaN
type: Species
is: HMDB02710
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H32N5O9 CHARGE: -1 INCHI: InChI=1/C20H33N5O9/c1-11(27)22-14(10-26)18(31)24-13(9-16(28)29)17(30)23-12(5-2-3-7-21)19(32)25-8-4-6-15(25)20(33)34/h12-15,26H,2-10,21H2,1H3,(H,22,27)(H,23,30)(H,24,31)(H,28,29)(H,33,34)/p-1/t12-,13+,14-,15-/m0/s1 EHMN_ABBREVIATION: CE5867
name: N-acetyl-seryl-aspartyl-lysyl-proline

metaM pyam5p c
is: SBO:0000247
type: Species
name: Pyridoxamine 5'-phosphate
is: C00647
initial amount: NaN
notes: FORMULA: C8H12N2O5P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00475 EHMN_ABBREVIATION: C00647
boundary condition: false
has only substance units: false
is: CHEBI:58451
is: HMDB01555
initial concentration: 1.0
constant: false

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_6451f399_773d_4119_8c75_64249a525650
is: SBO:0000252
is: P25325
initial amount: NaN
is encoded by: hsa:4357
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
constant: false
name: MPST

metaR NDPK10
type: Reaction
reactant: MODEL1310110012#
is described by: ECO:0000134
reversible: true
name: nucleoside-diphosphate kinase (ATP:dIDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#
product: MODEL1310110012#
fast: false

metaM 2dp6mep m
initial amount: NaN
notes: FORMULA: C57H88O2 CHARGE: 0 INCHI: InChI=1S/C57H88O2/c1-45(2)23-13-24-46(3)25-14-26-47(4)27-15-28-48(5)29-16-30-49(6)31-17-32-50(7)33-18-34-51(8)35-19-36-52(9)37-20-38-53(10)39-21-40-54(11)43-44-55-41-22-42-56(59-12)57(55)58/h22-23,25,27,29,31,33,35,37,39,41-43,58H,13-21,24,26,28,30,32,34,36,38,40,44H2,1-12H3/b46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+,54-43+
boundary condition: false
is: CHEBI:50774
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
name: 2-Decaprenyl-6-methoxyphenol

http://identifiers.org/biomodels.db/MODEL1310110012#_e7de8233_0d39_4c76_8dd0_f21ce0d01f94
constant: false
boundary condition: true
type: Species
is: Q8NFF2
name: SLC24A4
has only substance units: false
is encoded by: hsa:123041
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM ksi pre11 g
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:28067
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 11
initial concentration: 1.0
has only substance units: false
type: Species

metaM mi3p D c
has only substance units: false
boundary condition: false
name: 1D-myo-inositol 3-phosphate(2-)
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB06814
initial concentration: 1.0
is: CHEBI:58401
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m0/s1
constant: false

metaM gua c
type: Species
boundary condition: false
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: HMDB00132
is: SBO:0000247
name: Guanine
constant: false
is: CHEBI:16235
is: C00242
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM crn x
name: L-Carnitine
has only substance units: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: HMDB00062
is: SBO:0000247
is: C00318
boundary condition: false
is: CHEBI:16347
initial concentration: 1.0

metaR r1655
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM 3deccrn c
type: Species
notes: FORMULA: C17H33NO5 CHARGE: 0
is: HMDB00651
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
name: 3-hydroxydecanoylcarnitine

http://identifiers.org/biomodels.db/MODEL1310110012#_370bc76d_1558_40f8_9504_02bd728748dc
type: Species
is: B7Z792
name: NDUFS2
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:4720
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_741edce2_0902_4644_9bb7_8938310c54b2
constant: false
is: Q9UJM8
boundary condition: true
initial amount: NaN
name: HAO1
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:54363

metaM hexdicoa r
is: SBO:0000247
initial amount: NaN
is: HMDB00672
is: C08260
constant: false
type: Species
has only substance units: false
name: hexadecanedioylcoa
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
initial concentration: 1.0
boundary condition: false

metaM mag hs c
initial concentration: 1.0
is: SBO:0000247
is: HMDB12130
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
boundary condition: false
type: Species
is: CHEBI:16987
constant: false
name: monoacylglycerol 2
initial amount: NaN
has only substance units: false

metaR RE1448N
name: RE1448
product: MODEL1310110012#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110012#_49b73769_75a0_4ba1_b27c_68aaddc1fd63
is: Q53Y41
type: Species
initial concentration: NaN
has only substance units: false
name: DDC
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1644
constant: false

metaR r0591
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
reversible: true
modifier: MODEL1310110012#
is described by: ECO:0000000
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
product: MODEL1310110012#
type: Reaction
fast: false
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:

metaM abt e
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
initial amount: NaN
is: SBO:0000247
is: HMDB01851
constant: false
type: Species
initial concentration: 1.0
name: L-arabinitol
is: CHEBI:18403
has only substance units: false

metaM CE4790 m
constant: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
is: SBO:0000247
is: CHEBI:57923
boundary condition: false
has only substance units: false
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
initial amount: NaN
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_5266f5c5_c35b_4b09_b4c1_7b8c6006eb9f
name: ACSL6
is: SBO:0000252
is encoded by: hsa:23305
boundary condition: true
initial concentration: NaN
is: B2RB13
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaM bilirub e
initial amount: NaN
is: CHEBI:57977
is: SBO:0000247
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00054
constant: false
name: bilirubin(2-)

metaM mi14p c
is: SBO:0000247
has only substance units: false
is: CHEBI:58282
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
type: Species
is: HMDB00968
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN

metaM dnad c
has only substance units: false
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
initial concentration: 1.0
is: C00857
constant: false
is: CHEBI:18304
boundary condition: false
name: Deamino-NAD+
initial amount: NaN
is: HMDB01179
is: SBO:0000247
type: Species

metaM 2dodtricoa m
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
constant: false
is: C05279
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB11123
name: 2,6,9-dodecatrienoylcoa
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaM ksii core2 pre10 g
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:28067
boundary condition: false
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
name: keratan sulfate II biosynthesis, precursor 10
is: SBO:0000247
initial amount: NaN
type: Species

metaR r1656
fast: false
reactant: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110012#
is: SBO:0000185

metaR XYLTt
reversible: true
product: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
name: Xylitol transport via passive diffusion
is described by: ECO:0000000

metaR r0973
product: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
type: Reaction
name: Facilitated diffusion
kinetic law: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000185

metaM thcholstoic m
boundary condition: false
initial concentration: 1.0
is: CHEBI:18402
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
has only substance units: false
is: HMDB03873
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial amount: NaN
type: Species
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_7f98a65f_98e4_4726_b42d_7fd2c2cd2907
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
type: Species
name: _AI915649_1_c
initial concentration: NaN
is encoded by: hsa:AI915649

metaR r0590
kinetic law: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
is: SBO:0000176
reactant: MODEL1310110012#
reversible: false
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3

metaM ump g
type: Species
has only substance units: false
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
name: UMP(2-)
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57865
is: SBO:0000247

metaM prpp e
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
has only substance units: false
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
boundary condition: false
is: SBO:0000247
is: HMDB00280
is: CHEBI:58017
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_b6cd403d_7656_474f_83f7_a03e3c9d1415
has only substance units: false
is encoded by: hsa:AI656480
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: _AI656480_1_m
initial amount: NaN
boundary condition: true

metaM ha deg1 l
has only substance units: false
constant: false
is: CHEBI:16336
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C22H33N2O16 CHARGE: -1
name: hyaluronan degradation product 1

http://identifiers.org/biomodels.db/MODEL1310110012#_a2d5b84b_493b_48bc_aae5_7391a35fb5e9
is: SBO:0000252
constant: false
is encoded by: hsa:728637
name: _728637_1_c
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true

metaR r1657
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110012#
is: SBO:0000185
modifier: MODEL1310110012#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR CH25H
kinetic law: MODEL1310110012#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.14.99.38
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
reactant: MODEL1310110012#
name: cholesterol 25-hydroxylase
product: MODEL1310110012#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110012#

metaM gm3 hs g
type: Species
has only substance units: false
is: CHEBI:60065
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
constant: false
initial concentration: 1.0
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730

metaR r0974
is described by: ECO:0000000
product: MODEL1310110012#
name: Active transport
fast: false
reactant: MODEL1310110012#
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:

metaM hs deg9 l
boundary condition: false
is: CHEBI:17115
constant: false
initial amount: NaN
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
name: heparan sulfate, degradation product 9
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00187
has only substance units: false

metaM dece3coa m
is: SBO:0000247
boundary condition: false
name: 3-decenoylcoa
is: http://identifiers.org/pubchem.compound/16019966
type: Species
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
constant: false
has only substance units: false
initial concentration: 1.0

metaM mag hs e
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
boundary condition: false
constant: false
is: CHEBI:60479
initial amount: NaN
is: SBO:0000247
name: monoacylglycerol 2

metaM abt c
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
initial amount: NaN
is: SBO:0000247
is: HMDB01851
constant: false
initial concentration: 1.0
has only substance units: false
name: L-arabinitol
type: Species
is: CHEBI:18403

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaM 12ppd S c
initial amount: NaN
constant: false
is: CHEBI:29002
is: HMDB06213
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
initial concentration: 1.0
name: (S)-propane-1,2-diol
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false

metaM udpgal c
boundary condition: false
has only substance units: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: HMDB00302
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
is: CHEBI:58439
name: UDP-D-galactose(2-)
initial concentration: 1.0

metaM urea e
initial concentration: 1.0
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
name: Urea
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00294
boundary condition: false
is: CHEBI:16199
is: SBO:0000247
constant: false
is: C00086

metaM bilirub c
is: CHEBI:57977
is: HMDB00054
constant: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
name: bilirubin(2-)

http://identifiers.org/biomodels.db/MODEL1310110012#_97ea4283_b726_43a4_b62e_af264bce32f9
initial concentration: NaN
constant: false
is encoded by: hsa:80308
initial amount: NaN
boundary condition: true
type: Species
name: FLAD1
has only substance units: false
is: SBO:0000252

metaR AMETt2m
reactant: MODEL1310110012#
reversible: true
type: Reaction
kinetic law: MODEL1310110012#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110012#
is: SBO:0000185
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
product: MODEL1310110012#

metaR SEBACIDTD
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacic acid into cytosol (diffusion)
type: Reaction

metaR r1651
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000185
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false

metaM gcald c
boundary condition: false
constant: false
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:17071
is: HMDB03344
name: glycolaldehyde
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
initial concentration: 1.0

metaR S6T7g
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110012#
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
reactant: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#

metaR r0276
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.1.1.21
product: MODEL1310110012#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.2
modifier: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7

http://identifiers.org/biomodels.db/MODEL1310110012#_55d5d427_26f8_4a94_b319_00c5697405f4
boundary condition: true
name: ETFB
has only substance units: false
is encoded by: hsa:2109
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: P38117
initial amount: NaN

metaM so3 c
has only substance units: false
name: Sulfite
boundary condition: false
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: C00094
type: Species
initial amount: NaN
is: CHEBI:17137
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB00240

metaR ACGALtly
reactant: MODEL1310110012#
is described by: ECO:0000000
name: N-acetyl-galactosamine lysosomal efflux
fast: false
is: SBO:0000185
reversible: false
type: Reaction
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_48be1e79_faf5_4c02_9b27_2797db86ddaf
initial amount: NaN
name: PANK1
is encoded by: hsa:53354
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_c57883ad_47e7_429d_9272_331147dc7280
is: SBO:0000252
constant: false
is encoded by: hsa:230
initial concentration: NaN
is: P09972
type: Species
name: ALDOC
boundary condition: true
initial amount: NaN
has only substance units: false

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

metaM ksi pre27 g
is: SBO:0000247
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
is: HMDB00175
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:58053
initial concentration: 1.0
is: C00130
name: keratan sulfate I biosynthesis, precursor 27

http://identifiers.org/biomodels.db/MODEL1310110012#_3fbee266_7da1_4bae_b210_8397de74fd4a
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:216
name: ALDH1A1
is: P00352
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaM dopa c
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
name: dopaminium(1+)
is: HMDB00073
constant: false
is: CHEBI:59905
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758

metaR r1650
product: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110012#
type: Reaction
reversible: true
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110012#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM Asn X Ser Thr l
is: SBO:0000247
notes: FORMULA: XH CHARGE: 0
constant: false
has only substance units: false
initial amount: NaN
name: protein-linked asparagine residue (N-glycosylation site)
is: C01342
initial concentration: 1.0
is: HMDB00051
is: CHEBI:28938
boundary condition: false
type: Species

metaM adpcoa x
initial amount: NaN
is: HMDB04047
initial concentration: 1.0
is: C14143
type: Species
constant: false
has only substance units: false
boundary condition: false
name: adipoylcoa
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_2c9cdc8b_0d44_46bb_9e96_5b7b1970f014
initial amount: NaN
boundary condition: true
is: O15121
has only substance units: false
constant: false
is: SBO:0000252
name: DEGS1
is encoded by: hsa:8560
type: Species
initial concentration: NaN

metaR NAt3 1
reactant: MODEL1310110012#
reversible: true
name: sodium proton antiporter (H:NA is 1:1)
product: MODEL1310110012#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
type: Reaction
kinetic law: MODEL1310110012#
is: SBO:0000185

metaM crn m
is: HMDB00062
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: C00318
name: L-Carnitine
type: Species
has only substance units: false
initial concentration: 1.0

metaM pmtcoa x
name: Palmitoyl-CoA (n-C16:0CoA)
is: HMDB01338
type: Species
is: C00154
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:57379

http://identifiers.org/biomodels.db/MODEL1310110012#_ed33090d_9911_467e_953c_8c974699b529
is: O43924
type: Species
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:5147
boundary condition: true
is: SBO:0000252
name: PDE6D

metaM dgtp e
initial concentration: 1.0
constant: false
initial amount: NaN
name: dGTP
is: SBO:0000247
has only substance units: false
is: HMDB01440
type: Species
is: CHEBI:16497
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
boundary condition: false

metaM Tn antigen g
notes: FORMULA: C8H14NO5X CHARGE: 0
is: C04383
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
has only substance units: false
name: Tn antigen

metaM 5pmev c
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1
is: HMDB01343
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
name: (R)-5-phosphonatomevalonate(3-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_c7aca43a_133a_42ad_bf41_76438f7c7b00
is encoded by: hsa:341947
name: COX8C
is: Q7Z4L0
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species

metaM HC02180 e
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: thromboxane-b2
type: Species
is: CHEBI:28728
constant: false

metaR r1653
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000000
kinetic law: MODEL1310110012#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR C6CRNtcx
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexanoylcarnitine into cytosol
type: Reaction

metaR UREAt5
reversible: true
type: Reaction
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
name: urea, water cotransport
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110012#
fast: false
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:NCD

metaR PMEVKc
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added to substrate for elemental balancing.
reactant: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.4.2
is: SBO:0000176
fast: false
name: phosphomevalonate kinase, cytosol
modifier: MODEL1310110012#
type: Reaction
reversible: false

metaR SUBEACTD
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberic acid into cytosol (diffusion)
type: Reaction

metaR r2052
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
modifier: MODEL1310110012#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
product: MODEL1310110012#

metaR FOAXC122C101x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)x
type: Reaction

metaM fadh2 c
is: CHEBI:58307
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB01197
has only substance units: false
initial amount: NaN
constant: false
name: FADH2(2-)
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
boundary condition: false

metaR HIStN1
fast: false
kinetic law: MODEL1310110012#
is described by: ECO:0000269
reactant: MODEL1310110012#
name: Histidine transport (Na, H coupled)
type: Reaction
product: MODEL1310110012#
is: SBO:0000185
modifier: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827

metaR FAOXC101C102m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_05804a9d_4cdc_4e9d_aac8_9ad01aad328e
type: Species
is: SBO:0000297
is encoded by: hsa:5295
boundary condition: true
has only substance units: false
has part: B4DER4
constant: false
name: PIK3CB:PIK3R1
is encoded by: hsa:5291
initial amount: NaN
has part: B3KT19
initial concentration: NaN

metaM ksi deg13 l
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00812
notes: FORMULA: C174H280N12O150S8 CHARGE: -8
boundary condition: false
has only substance units: false
initial amount: NaN
name: keratan sulfate I, degradation product 13
constant: false
is: CHEBI:16953

metaR XYLUR
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.10
is: SBO:0000176
is described by: ECO:0000269
name: xylulose reductase
product: MODEL1310110012#
fast: false
type: Reaction
reactant: MODEL1310110012#
reversible: true
modifier: MODEL1310110012#

metaR r1652
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110012#
reactant: MODEL1310110012#
reversible: true
kinetic law: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110012#_f96ea361_7125_40dc_995d_d2cf7c7510f3
is: SBO:0000252
is encoded by: hsa:2585
boundary condition: true
initial concentration: NaN
name: GALK2
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaM tmndnccrn c
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
name: Timnodonyl carnitine
notes: FORMULA: C27H43NO4 CHARGE: 0 INCHI: InChI=1/C28H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-28(32)33-26(24-27(30)31)25-29(2,3)4/h6-7,9-10,12-13,15-16,18-19,26H,5,8,11,14,17,20-25H2,1-4H3/t26-/m0/s1
has only substance units: false
is: HMDB12130
is: CHEBI:16987
constant: false
initial concentration: 1.0

metaR EX lneldc LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoelaidic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_81efa478_a7df_4c1a_9b60_bfff09234c35
has part: P25705
constant: false
boundary condition: true
is: SBO:0000297
is encoded by: hsa:509
has part: Q6I9V2
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is encoded by: hsa:498
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM dopa e
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: HMDB00073
has only substance units: false
name: dopaminium(1+)
initial amount: NaN
is: CHEBI:59905
is: SBO:0000247
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaM gal c
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0
name: D-Galactose
is: SBO:0000247
initial concentration: 1.0
is: C00124
is: HMDB00143
is: CHEBI:0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_24dd4aab_de7a_40ae_b667_2b662eb5b65b
is: Q9BW60
is: SBO:0000252
initial amount: NaN
type: Species
name: ELOVL1
has only substance units: false
is encoded by: hsa:64834
boundary condition: true
constant: false
initial concentration: NaN

metaR C180CRNt
is described by: ECO:0000269
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
modifier: MODEL1310110012#
name: C180 transport into the mitochondria
kinetic law: MODEL1310110012#
fast: false
reversible: false
reactant: MODEL1310110012#
type: Reaction
is: SBO:0000185

metaR GALASE20ly
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000176
reactant: MODEL1310110012#
modifier: MODEL1310110012#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR CRNrtx
type: Reaction
product: MODEL1310110012#
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110012#
name: reversible transport of L-Carnitine in peroxisome
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
reactant: MODEL1310110012#
is: SBO:0000185

metaM Nacasp m
constant: false
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
name: N-acetyl-L-aspartate(2-)
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00812
initial concentration: 1.0
is: CHEBI:16953

metaM asp L m
initial concentration: 1.0
name: L-aspartate(1-)
is: SBO:0000247
constant: false
is: HMDB00191
boundary condition: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
type: Species
has only substance units: false
is: CHEBI:29991
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_5754b9fd_5e49_4790_94de_83ab754716db
constant: false
initial concentration: NaN
name: CHAT
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:1103
is: SBO:0000252
is: Q6LEN5

http://identifiers.org/biomodels.db/MODEL1310110012#_6d5224c2_1a64_46b6_b9ed_6fe2aa518e4b
has only substance units: false
is: Q6FIH7
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: ATP5G1
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:516

metaR LNLNCAt
reactant: MODEL1310110012#
fast: false
is described by: ECO:0000000
name: fatty acid transport via diffusion
type: Reaction
reversible: true
kinetic law: MODEL1310110012#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110012#

metaR AMPDA
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110012#
name: Adenosine monophosphate deaminase
type: Reaction
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.5.4.6
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_4522dcb9_4e93_4a48_be4c_4325d4576b0f
has only substance units: false
is: SBO:0000252
is: E5KNH5
initial amount: NaN
type: Species
is encoded by: hsa:4723
name: NDUFV1
boundary condition: true
initial concentration: NaN
constant: false

metaR GGH 7DHFe
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
fast: false
reversible: false
is: SBO:0000176
product: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
name: Gamma-glutamyl hydrolase (7DHF), extracellular
is described by: ECO:0000000
modifier: MODEL1310110012#

metaM 3decdicoa x
name: 3,7-decadienoylcoa
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0

metaR MACOXO
is described by: ECO:0000269
fast: false
is: SBO:0000176
modifier: MODEL1310110012#
name: 3-Methylimidazole acetaldehyde:NAD+ oxidoreductase
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.4.3.4
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (218.1) or (221.1) or (4129.1) or (222.1) or (220.1) SUBSYSTEM: Histidine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10344773 NOTES:SAB added 2 h to balance--not certain
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_cbad4b4d_7357_452b_bbf0_2cc6f5998716
name: ATP10A
has only substance units: false
type: Species
is: O60312
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:57194

metaM 3octdece1crn e
notes: FORMULA: C25H47NO5 CHARGE: 0
is: SBO:0000247
name: 3-hydroxy-octadecenoyl carnitine
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: HMDB13336
boundary condition: false

metaR SPRMTDe
fast: false
is described by: ECO:0000134
reversible: true
type: Reaction
kinetic law: MODEL1310110012#
name: absorption for spermine across the basolateral side
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: Larqu? E, Sabater-Molina M, Zamora S. (2007). Nutrition 23: 87-95, PMID: 11564949. NOTES:polyamines are taken up by diffusion process, although specific carriers and para-cellular transport has also been documented.
product: MODEL1310110012#
reactant: MODEL1310110012#

metaM HC02180 c
is: CHEBI:28728
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
constant: false
initial amount: NaN
type: Species
name: thromboxane-b2
is: SBO:0000247
has only substance units: false

metaR PE HSter
is described by: ECO:0000000
name: phosphatidylethanolamine scramblase
type: Reaction
reversible: true
reactant: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
is: SBO:0000185
product: MODEL1310110012#
kinetic law: MODEL1310110012#

metaM Tn antigen l
notes: FORMULA: C8H14NO5X CHARGE: 0
initial concentration: 1.0
name: Tn antigen
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
constant: false
boundary condition: false
is: C04383

http://identifiers.org/biomodels.db/MODEL1310110012#_a9f00eff_ad4c_4584_93d1_8831f1384bf6
initial amount: NaN
boundary condition: true
has only substance units: false
name: GPX6
type: Species
is: P59796
initial concentration: NaN
constant: false
is encoded by: hsa:257202
is: SBO:0000252

metaR PACCOAL
type: Reaction
reactant: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
is described by: ECO:0000000
kinetic law: MODEL1310110012#
product: MODEL1310110012#
fast: false
name: phenylacetate-CoA ligase
reversible: false

metaR C181CPT1
type: Reaction
name: transport of Octadecenoyl-CoA into mitochondrial matrix
fast: false
reactant: MODEL1310110012#
product: MODEL1310110012#
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110012#_237ded76_adb2_4aff_8647_fad3a3efee74
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q13232
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:4832
name: NME3
initial amount: NaN

metaM ksi deg24 l
type: Species
initial concentration: 1.0
name: keratan sulfate I, degradation product 24
is: SBO:0000247
has only substance units: false
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
constant: false
is: HMDB00143
boundary condition: false
is: CHEBI:12936
initial amount: NaN

metaM gal e
type: Species
is: C00124
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0
is: SBO:0000247
initial amount: NaN
name: D-Galactose
is: CHEBI:0
constant: false
has only substance units: false
boundary condition: false
is: HMDB00143

metaM undcoa m
type: Species
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C32H52N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB13114
name: undecanoylcoa

metaM cs e deg4 l
type: Species
is: HMDB00127
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4
is: CHEBI:15748
is: SBO:0000247
notes: FORMULA: C31H46NO38S4 CHARGE: -5
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_17091f53_b52d_4c48_bfb6_178e8567d5b5
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
name: HEXA
initial amount: NaN
is: P06865
type: Species
is encoded by: hsa:3073

metaR r1872
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110012#
is: SBO:0000185
reversible: false
fast: false

metaR H8TAer
notes: GENE_ASSOCIATION: (10026.1) and (8733.1) and (128869.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
product: MODEL1310110012#
name: H8 transamidase, endoplasmic reticulum
is: SBO:0000176
modifier: MODEL1310110012#
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000000

metaR EX 4mtolbutamide LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4 hydroxy tolbutamide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_0ef25b41_a9a5_4058_93d1_379a39256fb5
is: SBO:0000252
type: Species
is encoded by: hsa:759
is: P00915
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
name: CA1

http://identifiers.org/biomodels.db/MODEL1310110012#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

metaM 4abutn m
initial amount: NaN
name: 4-ammoniobutanal
type: Species
has only substance units: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
boundary condition: false
is: SBO:0000247
is: HMDB01080
constant: false
is: CHEBI:58264
initial concentration: 1.0

metaM 3mob e
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00019
is: CHEBI:11851
initial concentration: 1.0
constant: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
is: SBO:0000247
name: 3-methyl-2-oxobutanoate

metaR RE1804M
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
modifier: MODEL1310110012#
is described by: ECO:0000000
kinetic law: MODEL1310110012#
reversible: true
product: MODEL1310110012#
is: SBO:0000176
name: RE1804
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
type: Reaction

metaR TETPENT3t
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110012#
name: fatty acid transport via diffusion
kinetic law: MODEL1310110012#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110012#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_73b62808_1516_4c97_a458_14b487e77438
name: PAPSS2
is: O95340
boundary condition: true
is: SBO:0000252
is encoded by: hsa:9060
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN

metaM gpi hs r
is: HMDB03125
name: {[PE-Man-],[PE-]Man},{PE-}Man-GlcN-acylPI
boundary condition: false
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:16240

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_3b4d038c_ca7f_4f4a_865d_65003067ee26
constant: false
has only substance units: false
is encoded by: hsa:1629
type: Species
is: P11182
initial amount: NaN
name: DBT
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM urea m
is: CHEBI:16199
has only substance units: false
type: Species
name: Urea
initial amount: NaN
is: C00086
constant: false
is: HMDB00294
boundary condition: false
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_6964241e_79f8_436d_98dc_7070cebad085
name: NSDHL
initial concentration: NaN
has only substance units: false
is encoded by: hsa:50814
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q15738
constant: false

metaR r2056
is described by: ECO:0000000
reactant: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110012#
fast: false
product: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110012#_f4c3be63_2300_44f9_8d0d_54a0d4aa8fcb
is encoded by: hsa:27306
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
name: HPGDS
type: Species
is: O60760

metaM CE4872 m
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00127
constant: false
boundary condition: false
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
is: CHEBI:15748

http://identifiers.org/biomodels.db/MODEL1310110012#_f18bc0e5_dc53_432b_ae39_dfd2546a4313
initial concentration: NaN
has only substance units: false
is: P38571
is encoded by: hsa:3988
boundary condition: true
name: LIPA
constant: false
is: SBO:0000252
type: Species
initial amount: NaN

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_c5af0b6d_24f1_4bc5_ab9c_b837ba5778be
boundary condition: true
is encoded by: hsa:9963
is: Q9UHI7
is: SBO:0000252
name: SLC23A1
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_b0d17936_70ce_4eae_a7b3_e0dcafda7355
initial concentration: NaN
is encoded by: hsa:5290
has only substance units: false
constant: false
boundary condition: true
is: P42336
is: SBO:0000252
type: Species
name: PIK3CA
initial amount: NaN

metaR GCALDD
reactant: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000304
fast: false
reversible: false
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.2.1.36
name: Glycolaldehyde dehydrogenase
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110012#

metaM Asn X Ser Thr r
boundary condition: false
is: C01342
type: Species
is: CHEBI:28938
is: HMDB00051
name: protein-linked asparagine residue (N-glycosylation site)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
constant: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_ca833e19_29fe_4e20_97e2_7058b781009a
constant: false
name: AMACR
is encoded by: hsa:23600
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q3KT79
is: SBO:0000252
initial concentration: NaN
type: Species

metaR 3MOPte
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110012#
product: MODEL1310110012#
name: Transport of 3-methyl-2-oxopentanoate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM dmnoncoa c
has only substance units: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
is: HMDB11604
boundary condition: false
name: 4,8 dimethylnonanoyl-CoA
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
constant: false

metaM dgtp c
type: Species
is: CHEBI:16497
name: dGTP
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB01440
initial amount: NaN
boundary condition: false
is: C00286
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial concentration: 1.0

metaR DOCO13EFATP
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: absorption or uptake of 13-docosenoic acid into cells
type: Reaction

metaR FAOXC61x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)x
type: Reaction

metaM hs deg19 l
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
type: Species
is: HMDB06210
boundary condition: false
name: heparan sulfate, degradation product 19
has only substance units: false

metaM nadh c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB01487
constant: false
is: CHEBI:57945
name: Nicotinamide adenine dinucleotide - reduced
type: Species
boundary condition: false
is: C00004
is: http://identifiers.org/pubchem.compound/3306

http://identifiers.org/biomodels.db/MODEL1310110012#_961d52e8_5faf_403f_993e_bbc2f187c53d
is: SBO:0000252
is encoded by: hsa:3631
boundary condition: true
name: INPP4A
initial amount: NaN
constant: false
type: Species
has only substance units: false
initial concentration: NaN

metaR OCOAT1m
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (5019.1) or (64064.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.8.3.5 Confidence Level: 4 AUTHORS: PMID:10964512,PMID:11756565 NOTES:TDV
product: MODEL1310110012#
name: 3-oxoacid CoA-transferase
type: Reaction
is: SBO:0000176
reactant: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/2.8.3.5
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_8330ac89_fc6c_4fe6_b6c9_8279597257c3
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6508
boundary condition: true
type: Species
has only substance units: false
name: SLC4A3

metaR FUT14g
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.4.1.69
modifier: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
name: Galactoside 2-alpha-L-fucosyltransferase 1
is described by: ECO:0000269
reversible: false
product: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_60da0ad4_e6d2_40c4_9b29_a15f1daa8226
is: SBO:0000252
initial amount: NaN
is: P35575
has only substance units: false
is encoded by: hsa:2538
boundary condition: true
constant: false
name: G6PC
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_dd254bf3_4c0b_4b37_9102_c5426b455fd4
name: FASN
is: P49327
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2194
initial amount: NaN
is: SBO:0000252
constant: false

metaM e4hglu m
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
initial amount: NaN
is: HMDB02273
is: SBO:0000247
is: CHEBI:6331
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
name: erythro-4-hydroxy-L-glutamate(1-)

http://identifiers.org/biomodels.db/MODEL1310110012#_05f4d16b_9a7a_4f26_b0a5_c6ef740208c3
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
name: DPM2
constant: false
boundary condition: true
is: O94777
initial amount: NaN
is encoded by: hsa:8818

metaM crn c
boundary condition: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: HMDB00062
initial concentration: 1.0
initial amount: NaN
is: C00318
constant: false
name: L-Carnitine
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:16347

metaM HC01410 m
is: CHEBI:28706
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
is: SBO:0000247
type: Species
name: (2E)-Hexenoyl-CoA
boundary condition: false
has only substance units: false

metaM Nacasp c
name: N-acetyl-L-aspartate(2-)
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:16953
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00812
type: Species

metaR HSAT3ly
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000000
name: heparan-glucosaminide N-acetyltransferase, lysosomal
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD

metaR ACACT1rm
is version of: http://identifiers.org/ec-code/2.3.1.16
name: acetyl-CoA C-acetyltransferase, mitochondrial
fast: false
modifier: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
product: MODEL1310110012#
reversible: true

metaR DM 5hpet LPAREN r RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for 5(S)-HPETE(1-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_7efc2169_3e8b_4461_b6e7_7e29c5321f51
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: SULT1A3
is: P50224
is: SBO:0000252
type: Species
is encoded by: hsa:6818

http://identifiers.org/biomodels.db/MODEL1310110012#_9321125b_32a8_4159_b9e7_370683c447d1
initial amount: NaN
is: O94903
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:11212
name: PROSC
constant: false
is: SBO:0000252
initial concentration: NaN

metaM 3mlda c
initial concentration: 1.0
is: C05828
is: HMDB02820
is: http://identifiers.org/pubchem.compound/8122
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
type: Species
has only substance units: false
name: 3-Methylimidazoleacetic acid
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828

metaR RE1826C
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000176
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
name: RE1826
product: MODEL1310110012#

metaR LNLCCRNt
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
reactant: MODEL1310110012#
product: MODEL1310110012#
reversible: false
name: transport into the mitochondria (carnitine)
is: SBO:0000185

metaM acnam n
initial concentration: 1.0
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: SBO:0000247
is: CHEBI:35418
initial amount: NaN
has only substance units: false
name: N-acetylneuraminate
type: Species
boundary condition: false
constant: false
is: HMDB00230

http://identifiers.org/biomodels.db/MODEL1310110012#_258c610c_21e7_4213_98df_79506f97e06c
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: O95169
has only substance units: false
name: NDUFB8
is encoded by: hsa:4714
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_4879b963_1fac_42d5_ad44_44f594b1c9a9
is: SBO:0000252
is: P23634
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:493
name: ATP2B4
constant: false
initial concentration: NaN
has only substance units: false

metaR ARACHCRNt
name: transport into the mitochondria (carnitine)
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110012#
is described by: ECO:0000000
reactant: MODEL1310110012#
is: SBO:0000185
product: MODEL1310110012#
reversible: false
kinetic law: MODEL1310110012#
fast: false

metaR RE3627M
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is: SBO:0000176
reversible: true
product: MODEL1310110012#
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
kinetic law: MODEL1310110012#
name: RE3627
fast: false
is described by: ECO:0000000
modifier: MODEL1310110012#

metaR r1540
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
product: MODEL1310110012#
reversible: false
kinetic law: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
modifier: MODEL1310110012#
is: SBO:0000185
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3

http://identifiers.org/biomodels.db/MODEL1310110012#_f8047bdd_84b7_4f0f_9e18_b99ce4571954
is encoded by: hsa:7001
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: PRDX2

http://identifiers.org/biomodels.db/MODEL1310110012#_f160cdf1_7d32_40fa_96ce_233c3cc4e14e
is: Q99519
name: NEU1
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:4758

metaM 3octdece1crn c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
name: 3-hydroxy-octadecenoyl carnitine
boundary condition: false
constant: false
notes: FORMULA: C25H47NO5 CHARGE: 0
is: HMDB13336
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_b39602e5_92a4_4555_9fa5_c522c7a17a90
has only substance units: false
initial concentration: NaN
is encoded by: hsa:217
name: ALDH2
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is: P05091

http://identifiers.org/biomodels.db/MODEL1310110012#_e84108fe_2290_4375_b9fd_c6e00b3e57a5
name: GALNT1
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2589
initial amount: NaN
is: Q10472
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_50f1a99e_70a6_40dc_9dec_7be7ec0b0f9b
name: _AI440329_1_r
boundary condition: true
is encoded by: hsa:AI440329
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_dff82e6b_4cd3_44fe_8afd_1f0646142b58
name: GCDH
constant: false
is: Q92947
is encoded by: hsa:2639
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM 3mob c
name: 3-methyl-2-oxobutanoate
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
initial amount: NaN
is: HMDB00019
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:11851
constant: false
boundary condition: false

metaR S4TASE5ly
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.12
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is: SBO:0000176
product: MODEL1310110012#
is described by: ECO:0000000
name: N-acetylgalactosamine-4-sulfatase, lysosomal
reactant: MODEL1310110012#
fast: false

metaR r1765
is described by: ECO:0000000
product: MODEL1310110012#
reversible: false
reactant: MODEL1310110012#
is: SBO:0000185
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
fast: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR SCP22x
is: SBO:0000185
name: Sterol carrier protein 2
fast: false
reactant: MODEL1310110012#
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: true
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.176
is described by: ECO:0000000

metaM cit m
is: C00158
name: Citrate
boundary condition: false
is: HMDB00094
initial amount: NaN
type: Species
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: CHEBI:16947
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false

metaR RETH2e
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
name: retinyl ester hydrolase (11-cis), extracellular
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_51a9fcca_66e9_4bae_a444_d01fbaee2d28
constant: false
type: Species
name: GAPDH
is: E7EUT4
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2597
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM 3mlda e
is: C05828
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
initial concentration: 1.0
is: HMDB02820
initial amount: NaN
is: http://identifiers.org/pubchem.compound/8122
constant: false
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
name: 3-Methylimidazoleacetic acid

metaM gal l
type: Species
name: D-galactose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
is: CHEBI:12936
constant: false
is: HMDB00143
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM acnam l
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: HMDB00230
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: N-acetylneuraminate
is: CHEBI:35418
boundary condition: false

metaR ALCD22 D
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.1.1.1
product: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.99.24
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (126.1) or (137872.1) or (126.1 and 124.1) or (127.1) or (130.1) or (284273.1) or (125.1 and 124.1) or (128.1) or (124.1) or (125.1) or (284273.2) or (131.1) or (125.1 and 126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.78 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
modifier: MODEL1310110012#
is described by: ECO:0000304
name: alcohol dehydrogenase (D-lactaldehyde)
fast: false
kinetic law: MODEL1310110012#

metaM c8dc c
is: C02838
initial amount: NaN
notes: FORMULA: C15H26NO6 CHARGE: -1
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
name: suberyl carnitine
boundary condition: false
has only substance units: false
is: HMDB00791

metaM ksii core2 deg1 l
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 1
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
is: CHEBI:57737
is: HMDB00868
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_13bbad3c_e64a_4f81_ae83_b29eac17fc33
is: Q7Z364
initial concentration: NaN
is encoded by: hsa:5153
name: PDE1B
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false

metaM i c
is: SBO:0000247
type: Species
name: iodide
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB12238
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
initial amount: NaN
boundary condition: false
is: CHEBI:16382

metaM sbt D c
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
name: D-glucitol
is: HMDB00247
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
is: CHEBI:17924

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaM ksi deg15 l
boundary condition: false
type: Species
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
constant: false
initial amount: NaN
is: HMDB00143
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate I, degradation product 15
is: CHEBI:12936

metaR B3GNT31g
reversible: false
kinetic law: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#
type: Reaction
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000269
fast: false

metaR EX tststerones LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: testosterone sulfate exchange
type: Reaction

metaR r0390
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
is: SBO:0000176
product: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
reversible: true
type: Reaction
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
kinetic law: MODEL1310110012#
is described by: ECO:0000000

metaR r1446
is described by: ECO:0000000
reactant: MODEL1310110012#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
fast: false
kinetic law: MODEL1310110012#
name: EC:1.3.3.6
product: MODEL1310110012#
reversible: false

metaM 4abutn e
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB01080
boundary condition: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
name: 4-ammoniobutanal
is: CHEBI:58264
type: Species
has only substance units: false

metaM cbasp c
type: Species
is: C00438
is: SBO:0000247
name: N-Carbamoyl-L-aspartate
is: CHEBI:32814
is: HMDB00828
constant: false
boundary condition: false
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR FAOXC61m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

metaR XOLTRIOLtm
is described by: ECO:0000000
product: MODEL1310110012#
name: lipid, flip-flop intracellular transport
is: SBO:0000185
type: Reaction
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reversible: true
fast: false
kinetic law: MODEL1310110012#

metaR NAt
modifier: MODEL1310110012#
reversible: true
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
product: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (6526.1) or (6523.1) or (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:1372904,PMID:15546855,PMID:2490366,PMID:7537337,PMID:7789985,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:
name: sodium transport (uniport)

metaM hexdicoa c
is: SBO:0000247
is: HMDB02014
constant: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
type: Species
boundary condition: false
has only substance units: false
name: hexadecanedioylcoa
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_ed646594_54aa_47e0_a5da_4d719e2fffd9
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:5295
initial concentration: NaN
initial amount: NaN
name: PIK3R1
is: P27986
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_c3d47f3e_1e6e_4c82_8268_41d4f1e8409f
is: Q9NRR6
name: INPP5E
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:56623
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR r1544
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110012#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110012#
product: MODEL1310110012#
type: Reaction

metaM 4hbzcoa m
type: Species
is: SBO:0000247
name: 4-hydroxybenoyl-CoA
is: HMDB06467
notes: FORMULA: C28H36N7O18P3S CHARGE: -4 INCHI: InChI=1/C28H40N7O18P3S/c1-28(2,22(39)25(40)31-8-7-18(37)30-9-10-57-27(41)15-3-5-16(36)6-4-15)12-50-56(47,48)53-55(45,46)49-11-17-21(52-54(42,43)44)20(38)26(51-17)35-14-34-19-23(29)32-13-33-24(19)35/h3-6,13-14,17,20-22,26,36,38-39H,7-12H2,1-2H3,(H,30,37)(H,31,40)(H,45,46)(H,47,48)(H2,29,32,33)(H2,42,43,44)/t17-,20?,21-,22+,26-/m1/s1
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_936942e2_5763_4de1_b8af_7839ff430724
type: Species
is: A6H8L5
initial amount: NaN
is encoded by: hsa:3990
is: SBO:0000252
has only substance units: false
boundary condition: true
name: LIPC
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_6587c647_0b05_4ec0_9138_f4a049bd881f
constant: false
initial amount: NaN
name: ALPL
is encoded by: hsa:249
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is: B7Z4Y6
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110012#_4d7ea7eb_5a90_450e_9c91_28ba88721a09
boundary condition: true
is: O43511
name: SLC26A4
initial concentration: NaN
is encoded by: hsa:5172
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
has only substance units: false

metaM crn e
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial amount: NaN
is: C00318
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: L-Carnitine
is: SBO:0000247
is: CHEBI:16347
is: HMDB00062

metaM xylu L c
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
name: L-xylulose
is: HMDB00751
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:17399

http://identifiers.org/biomodels.db/MODEL1310110012#_aee9cb6c_5257_4c5a_85a8_28b02b07bde7
is: SBO:0000252
initial concentration: NaN
is: Q1LZ56
is encoded by: hsa:206358
constant: false
name: SLC36A1
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false

metaM dmnoncoa m
type: Species
constant: false
initial amount: NaN
name: 4,8 dimethylnonanoyl-CoA
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
is: SBO:0000247
has only substance units: false
is: HMDB11604
initial concentration: 1.0
boundary condition: false

metaM HC10852 r
is: CHEBI:61540
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
initial concentration: 1.0
initial amount: NaN
name: palmitoleyl-CoA(4-)
constant: false

metaR CYTDK1
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: ATPcytidine 5-phosphotransferase
fast: false
reversible: false
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.1.48
modifier: MODEL1310110012#
is described by: ECO:0000254
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_88a3cbb8_344f_4f3a_9f32_ea8a12c3111a
name: ALDH1A3
is: SBO:0000252
initial concentration: NaN
is: P47895
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:220
boundary condition: true

metaR GLYCTDle
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: difussion of glycerol accross the brush border membrane
reversible: true
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000134
type: Reaction
fast: false
reactant: MODEL1310110012#
is: SBO:0000185

metaM sbt D e
has only substance units: false
boundary condition: false
initial amount: NaN
name: D-glucitol
initial concentration: 1.0
constant: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
type: Species
is: SBO:0000247
is: HMDB00247

metaR ACNAMPH
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: N-Acetylneuraminate 9-phosphate phosphohydrolase
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
reversible: false
product: MODEL1310110012#
type: Reaction

metaM ipdp c
is: HMDB01347
boundary condition: false
constant: false
is: CHEBI:128769
name: Isopentenyl diphosphate
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
is: C00129
is: SBO:0000247
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_60737828_f64e_4b73_9567_a0b3b493bda2
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
name: HAO2
is: SBO:0000252
is encoded by: hsa:51179
boundary condition: true
type: Species

metaM lnlccrn c
initial amount: NaN
is: HMDB06469
name: Linoleyl carnitine
is: SBO:0000247
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
has only substance units: false

metaR S6TASE25ly
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
product: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110012#
is: SBO:0000176
name: galactose-6-sulfate sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: true

metaR RE1804C
type: Reaction
is: SBO:0000176
fast: false
name: RE1804
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reversible: true
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000000
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_db2849ca_a6d8_4939_b938_de28081a7bfd
boundary condition: true
initial amount: NaN
name: ANPEP
type: Species
is: Q59E93
is encoded by: hsa:290
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false

metaR ASPTAm
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
reactant: MODEL1310110012#
is described by: ECO:0000269
type: Reaction
name: aspartate transaminase
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reversible: true
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110012#_5d29e84b_1e31_4fc8_b33c_f0a6754ca211
type: Species
boundary condition: true
is encoded by: hsa:100128062
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: _100128062_1_m
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_06824fba_89fb_477f_b1c8_2aead67d9053
boundary condition: true
type: Species
is encoded by: hsa:112
has only substance units: false
is: SBO:0000252
constant: false
is: O43306
initial concentration: NaN
name: ADCY6
initial amount: NaN

metaR r0166
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
product: MODEL1310110012#
fast: false
is: SBO:0000176
reversible: false
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19

http://identifiers.org/biomodels.db/MODEL1310110012#_962b15e8_cb46_40ae_a3d7_cd61132c4915
boundary condition: true
is: P25705
initial amount: NaN
name: ATP5A1
type: Species
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:498

http://identifiers.org/biomodels.db/MODEL1310110012#_473d64ad_550f_48e8_b31f_3d9fca5bc8d2
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
name: VNN3
constant: false
is encoded by: hsa:55350
is: SBO:0000252
initial concentration: NaN

metaM hs deg14 l
initial amount: NaN
name: heparan sulfate, degradation product 14
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:16126
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
boundary condition: false
type: Species

metaM c226coa x
initial amount: NaN
type: Species
name: cervonyl coenzyme A
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205479
constant: false
initial concentration: 1.0
is: C16169
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_ac128e16_bb90_47c7_af0b_03d1928f2e3d
type: Species
is: SBO:0000252
boundary condition: true
is: P15531
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: NME1
constant: false
is encoded by: hsa:4830

metaM od2coa c
is: C16218
is: SBO:0000247
name: trans-Octadec-2-enoyl-CoA
boundary condition: false
constant: false
is: HMDB06529
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:50570
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244
type: Species

metaR PUNP7
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110012#
type: Reaction
fast: false
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
modifier: MODEL1310110012#
is described by: ECO:0000269
reactant: MODEL1310110012#
name: purine-nucleoside phosphorylase (Xanthosine)
is: SBO:0000176
reversible: true

metaM estrones c
notes: FORMULA: C18H21O5S CHARGE: -1 INCHI: InChI=1S/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/p-1/t14-,15-,16+,18+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00961 EHMN_ABBREVIATION: C02538
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:60050
initial amount: NaN
name: estrone 3-sulfate(1-)
is: HMDB01425

metaM cit e
has only substance units: false
is: CHEBI:16947
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
name: citrate(3-)
is: HMDB00094
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_64f55cd4_b038_477b_80a2_fe9db7d1da1a
type: Species
is: P03905
is: SBO:0000252
boundary condition: true
name: ND4
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4538
constant: false

metaR ACACt2m
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
type: Reaction
modifier: MODEL1310110012#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110012#
fast: false
name: Acetoacetate mitochondrial transport via H+ symport
is described by: ECO:0000269
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_c48303e0_1bf6_45f8_a28e_7d3d288f59e4
name: B3GNT5
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q9BYG0
boundary condition: true
initial amount: NaN
is encoded by: hsa:84002

http://identifiers.org/biomodels.db/MODEL1310110012#_3c930f05_a52d_480b_b02d_c4b727b55572
name: ATP1B3
is: SBO:0000252
is: P54709
is encoded by: hsa:483
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR DOLP Uter
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110012#
name: dolichol phosphate flippase (uterus)
kinetic law: MODEL1310110012#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110012#_975d66b7_4b63_46ae_9c21_dcb64a649676
is: SBO:0000297
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:54344
has part: O94777
initial concentration: NaN
is encoded by: hsa:8818
has part: Q86TM7
name: DPM3:DPM1:DPM2
constant: false
is encoded by: hsa:8813
has part: O60762

metaM pydam c
name: Pyridoxamine
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
constant: false
initial amount: NaN
is: CHEBI:57761
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: C00534
is: HMDB01431

metaM 5fthf e
boundary condition: false
has only substance units: false
is: CHEBI:57457
is: HMDB01562
name: 5-formyltetrahydrofolate(2-)
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_e1894652_95a9_4274_a75e_4766f44eadce
is encoded by: hsa:376497
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
name: SLC27A1
is: Q6PCB7
initial concentration: NaN
type: Species
boundary condition: true

metaR RE1897C
reactant: MODEL1310110012#
reversible: true
is described by: ECO:0000000
name: RE1897
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110012#_2089dbad_5263_4cee_a70a_ffc4af98446f
name: SLC24A4
initial amount: NaN
is encoded by: hsa:123041
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true

metaM gluside hs l
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
is: SBO:0000247
initial amount: NaN
name: D-glucosyl-N-acylsphingosine
constant: false
has only substance units: false
is: CHEBI:18368

metaR SQLEr
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
name: Squalene epoxidase, endoplasmic reticular (NADP)
reactant: MODEL1310110012#
product: MODEL1310110012#
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
reversible: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.14.13.132

metaR M4MPDOL Uter
type: Reaction
product: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110012#
is: SBO:0000185
name: m4mpdol flippase
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_399aaa1f_ca7b_4c6e_a0af_c493073fd6fb
is: Q16760
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: DGKD
constant: false
is encoded by: hsa:8527
type: Species
boundary condition: true
is: SBO:0000252

metaR PUNP6
is described by: ECO:0000269
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
name: purine-nucleoside phosphorylase (Deoxyinosine)
modifier: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
reversible: true
product: MODEL1310110012#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false

metaM i e
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB12238
initial concentration: 1.0
name: iodide
type: Species
is: CHEBI:16382
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708

metaM datp c
initial amount: NaN
name: dATP
is: HMDB01532
initial concentration: 1.0
type: Species
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: C00131
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:61404
has only substance units: false

metaM HC00229 e
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:28189
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
constant: false
initial concentration: 1.0
name: Isomaltose
has only substance units: false
initial amount: NaN

metaR TETDEC2CRNe
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of tetradecadienoyl carnitine into extra cellular space
type: Reaction

metaR CORE3GTg
fast: false
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
kinetic law: MODEL1310110012#
type: Reaction
reversible: false
reactant: MODEL1310110012#
is described by: ECO:0000000
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
is: SBO:0000176
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.4.1.149

http://identifiers.org/biomodels.db/MODEL1310110012#_0a7220d6_5b2c_49f4_b0ee_43026acb9088
is: O95573
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
name: ACSL3
is encoded by: hsa:2181

metaM HC02210 c
name: prostaglandin-d3
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
is: CHEBI:34939
is: SBO:0000247
type: Species

metaR 3DPHBH2
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212 NOTES:Used to make Ubiquinone-10 enzyme has not been identified yet. IT
kinetic law: MODEL1310110012#
name: Hydroxylation of 3-Decaprenyl-4-hydroxybenzoate (NADPH)
type: Reaction
reactant: MODEL1310110012#
is described by: ECO:0000000
product: MODEL1310110012#
fast: false

metaR r0488
kinetic law: MODEL1310110012#
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
product: MODEL1310110012#
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
reversible: true
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:

metaR RE2799C
type: Reaction
is described by: ECO:0000000
name: RE2799
is: SBO:0000176
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
reversible: true
fast: false
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_368bcf0a_9736_4f83_9bf7_8a79768a8b3c
is encoded by: hsa:92745
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: SLC38A5
type: Species
is: Q8WUX1
is: SBO:0000252
constant: false

metaR 3HBCDm
is: SBO:0000176
reversible: true
fast: false
notes: GENE_ASSOCIATION: (55268.1) SUBSYSTEM: Butanoate metabolism EC Number: 4.2.1.55 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:NCD. rat gene that is homologous to the human gene encodes for this activity
product: MODEL1310110012#
name: 3-hydroxybutyryl-CoA dehydratase, mitochondrial
kinetic law: MODEL1310110012#
is described by: ECO:0000254
modifier: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction

metaM ksii core2 pre2 g
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:58053
type: Species
initial concentration: 1.0
constant: false
is: C00130
name: keratan sulfate II biosynthesis, precursor 2
is: HMDB00175
notes: FORMULA: C39H63N3O28X CHARGE: -1

metaM 34dhoxmand m
boundary condition: false
is: SBO:0000247
is: HMDB01866
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
is: CHEBI:27637
type: Species
has only substance units: false
name: 3,4-Dihydroxymandelate

metaR DIDPtn
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
name: dIDP nuclear transport

metaR GGH 6THFe
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110012#
fast: false
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (6THF), extracellular
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
type: Reaction
reversible: false
product: MODEL1310110012#

metaM pristcoa x
name: pristanoyl coa
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:51341
is: SBO:0000247

metaM hs deg2 l
name: heparan sulfate, degradation product 2
boundary condition: false
has only substance units: false
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
is: HMDB06210
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM c81crn c
type: Species
notes: FORMULA: C15H27NO4 CHARGE: 0
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
name: octenoyl carnitine
is: HMDB13324

http://identifiers.org/biomodels.db/MODEL1310110012#_425e3d09_131c_454c_ab62_6da71208c0ab
name: MTHFD1L
type: Species
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:25902
is: B2RD24
initial concentration: NaN

metaR RE3005M
product: MODEL1310110012#
type: Reaction
reversible: true
kinetic law: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
name: RE3005
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110012#_69a03c73_db48_4fe9_ba58_5192802a2e11
has only substance units: false
name: LGALS13
is: SBO:0000252
is: Q9UHV8
initial amount: NaN
type: Species
is encoded by: hsa:29124
constant: false
initial concentration: NaN
boundary condition: true

metaM paps c
is: CHEBI:58339
has only substance units: false
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
initial amount: NaN
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01134
constant: false

metaR UMPK
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110012#
reversible: true
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_1f522b20_83af_4e3c_b94c_7d3c024a4147
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
name: GUCY2C
has only substance units: false
is: P25092
is encoded by: hsa:2984

http://identifiers.org/biomodels.db/MODEL1310110012#_a6f8d974_9df3_4a9c_a379_ae88e815db56
is encoded by: hsa:3633
name: INPP5B
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is: P32019
initial concentration: NaN
type: Species

metaM ksi pre9 g
is: SBO:0000247
is: CHEBI:58053
is: HMDB00175
initial concentration: 1.0
boundary condition: false
is: C00130
name: keratan sulfate I biosynthesis, precursor 9
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
constant: false
has only substance units: false
initial amount: NaN
type: Species

metaR MTHFDm
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.9
is version of: http://identifiers.org/ec-code/6.3.4.3
is described by: ECO:0000269
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
product: MODEL1310110012#
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_86390857_fe7a_4c57_ae14_7ab68865bc8f
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P12074
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:1337
name: COX6A1

http://identifiers.org/biomodels.db/MODEL1310110012#_19482ca6_1b03_4084_86be_c9ab40c54973
initial concentration: NaN
initial amount: NaN
is: O15056
is: SBO:0000252
type: Species
boundary condition: true
constant: false
has only substance units: false
name: SYNJ2
is encoded by: hsa:8871

metaR G6PDH2rer
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.1.1.47
fast: false
modifier: MODEL1310110012#
is described by: ECO:0000269
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110012#
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
product: MODEL1310110012#

metaR C9BRxtc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dimethylnonanoylcarnitine from peroxisomes to cytosol
type: Reaction

metaM acglcgalgbside hs g
name: GlcNAc-Gal globoside
is: CHEBI:26174
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0
is: SBO:0000247
type: Species

metaM odecrn c
is: CHEBI:57394
type: Species
is: SBO:0000247
name: octadecenoyl carnitine
initial concentration: 1.0
is: C00412
boundary condition: false
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
has only substance units: false
constant: false
is: HMDB01114
initial amount: NaN

metaM HC02210 e
initial amount: NaN
name: prostaglandin-d3
has only substance units: false
initial concentration: 1.0
is: CHEBI:34939
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
constant: false

metaR FAOXC184C163x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:3)x
type: Reaction

metaR PUNP3
is: SBO:0000176
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110012#
fast: false
reversible: true
name: purine-nucleoside phosphorylase (Guanosine)
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
modifier: MODEL1310110012#
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_1a523436_fafd_4df6_99d7_9f88dac2e47d
is encoded by: hsa:8659
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: ALDH4A1

metaM cspg b e
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
boundary condition: false
has only substance units: false
is: CHEBI:16040
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
is: HMDB00630

http://identifiers.org/biomodels.db/MODEL1310110012#_f4969505_f9c2_4c27_b2ce_34100966f858
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
name: _AA081045_1_c
boundary condition: true
is encoded by: hsa:AA081045
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_a60fde44_5109_4b49_857c_b7f7ae22ec2f
constant: false
boundary condition: true
is: C5HZ13
is: SBO:0000252
is encoded by: hsa:1178
initial amount: NaN
has only substance units: false
name: CLC
initial concentration: NaN
type: Species

metaR NADtpu
type: Reaction
is described by: ECO:0000000
reversible: false
name: NAD transporter, peroxisome
reactant: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ

metaR FAOXC81C61x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)x
type: Reaction

metaR CHOLESTle
is: SBO:0000176
fast: false
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
name: hydrolysis of cholesterol ester by cholesterol esterase
reversible: false
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.1.1.13
reactant: MODEL1310110012#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110012#_07a87df4_1cec_42a0_b891_0bade4db1233
is encoded by: hsa:6532
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
name: SLC6A4
is: P31645
is: SBO:0000252

metaR NACASPAH
fast: false
notes: GENE_ASSOCIATION: (443.1) or (91703.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.15 Confidence Level: 4 AUTHORS: PMID:8252036 NOTES:SAB
product: MODEL1310110012#
is: SBO:0000176
name: N-Acetyl-L-aspartate amidohydrolase
is version of: http://identifiers.org/ec-code/3.5.1.15
reversible: false
kinetic law: MODEL1310110012#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110012#
modifier: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_e0af9c62_7774_4bc8_a9ea_6aac23da8d11
is: SBO:0000252
constant: false
is: Q99755
type: Species
boundary condition: true
is encoded by: hsa:8394
initial amount: NaN
initial concentration: NaN
name: PIP5K1A
has only substance units: false

metaR FAOXC101C102x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)x
type: Reaction

metaR 7DHCHSTEROLtr
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110012#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
name: cholesterol precursor intracellular transport
product: MODEL1310110012#
kinetic law: MODEL1310110012#

metaM ksii core2 pre1 g
is: CHEBI:28067
initial concentration: 1.0
notes: FORMULA: C33H53N3O23X CHARGE: -1
boundary condition: false
constant: false
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 1

metaR PUNP2
product: MODEL1310110012#
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
name: purine-nucleoside phosphorylase (Deoxyadenosine)
modifier: MODEL1310110012#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is: SBO:0000176
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110012#_affe1977_9c5b_4743_8de3_4fcd04dcd513
is: SBO:0000252
initial concentration: NaN
name: SLC25A10
has only substance units: false
boundary condition: true
is: Q9UBX3
constant: false
is encoded by: hsa:1468
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_3d53ee35_a5d7_49dc_8c5e_e361af258248
is encoded by: hsa:2182
name: ACSL4
constant: false
is: Q5JWV8
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR NTD1
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
kinetic law: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#
is described by: ECO:0000269
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.1.3.5
fast: false
type: Reaction
product: MODEL1310110012#
reversible: false
name: 5'-nucleotidase (dUMP)

metaM ptth c
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:16753
name: pantetheine
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: SBO:0000247
constant: false
is: HMDB03426
initial concentration: 1.0
boundary condition: false

metaM lnlccrn m
name: Linoleyl carnitine
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
is: SBO:0000247
is: HMDB06469
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
constant: false

metaM HC00319 m
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
name: Malonate
boundary condition: false
has only substance units: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
is: CHEBI:30794

http://identifiers.org/biomodels.db/MODEL1310110012#_6df06eb6_cdbe_47cf_a535_c18973d874e1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: PGM3
type: Species
boundary condition: true
is: B4DX94
has only substance units: false
constant: false
is encoded by: hsa:5238

metaM xylt e
is: HMDB02917
name: xylitol
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
type: Species
is: CHEBI:17151
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379

metaM gluside hs g
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
name: D-glucosyl-N-acylsphingosine
constant: false
initial concentration: 1.0
is: CHEBI:18368
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
has only substance units: false

metaR TYRt
kinetic law: MODEL1310110012#
type: Reaction
fast: false
product: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000269
reversible: true
name: L-tyrosine transport
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
is: SBO:0000185
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_e1874598_1e60_463f_bd3a_3758344ebc45
boundary condition: true
name: SLC7A8:SLC3A2
has part: Q9UHI5
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:23428
is: SBO:0000297
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_a41f4673_d892_40a0_84f4_7e7d0505667b
boundary condition: true
is: E5KNH5
name: NDUFV1
type: Species
is encoded by: hsa:4723
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN

metaR DMHPTCRNCPT2
fast: false
kinetic law: MODEL1310110012#
is: SBO:0000176
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:made reversible since Keq ~ 0.6. dmhptcoa is a special case because its biochemical fate has not be elucidated. NJ
name: 2,6 dimethylheptanoly CoA carnitine transferase
product: MODEL1310110012#
is described by: ECO:0000000
reactant: MODEL1310110012#

metaR PUNP5
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110012#
name: purine-nucleoside phosphorylase (Inosine)
type: Reaction
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
product: MODEL1310110012#
fast: false
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110012#
reversible: true

metaR PROSTGI2tr
is: SBO:0000185
is described by: ECO:0000269
name: Prostaglandin I2 transport (ER)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
fast: false
kinetic law: MODEL1310110012#
reversible: true
product: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_1f66afa7_ba8b_4769_8a6f_2d44ee99b7ee
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:2720
has only substance units: false
has part: P34059
type: Species
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:4758
is encoded by: hsa:2588
has part: P10619
is encoded by: hsa:5476
name: GALNS:GLB1:NEU1:CTSA
has part: P16278
has part: Q99519

http://identifiers.org/biomodels.db/MODEL1310110012#_b934e8d5_fb1b_404a_b2a8_908be7d1d86d
initial amount: NaN
boundary condition: true
is: O76062
name: TM7SF2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:7108
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_ff10996c_91cd_442c_ae95_da6099cce4c5
initial concentration: NaN
name: SULT1A1
type: Species
initial amount: NaN
is encoded by: hsa:6817
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_7b03c4cd_4982_47ee_8119_660dc469e736
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
name: PDE9A
is encoded by: hsa:5152
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_d66c359b_6c29_4636_8b1d_26841df9c1bc
initial amount: NaN
name: SCD
type: Species
is: O00767
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6319

metaM 5fthf c
initial amount: NaN
boundary condition: false
is: HMDB01562
has only substance units: false
is: CHEBI:57457
is: SBO:0000247
type: Species
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
constant: false
name: 5-formyltetrahydrofolate(2-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_906cd1e4_148c_42af_94e7_30ac11b27c93
type: Species
constant: false
is encoded by: hsa:AI653169
is: SBO:0000252
name: _AI653169_1_c
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR CSNAT2x
type: Reaction
modifier: MODEL1310110012#
is: SBO:0000176
product: MODEL1310110012#
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.7
kinetic law: MODEL1310110012#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
reactant: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.137

metaR ALCD22 L
is version of: http://identifiers.org/ec-code/1.1.99.24
reversible: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110012#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.1.1.1
product: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (126.1) or (137872.1) or (126.1 and 124.1) or (127.1) or (130.1) or (284273.1) or (125.1 and 124.1) or (128.1) or (124.1) or (125.1) or (284273.2) or (131.1) or (125.1 and 126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
reactant: MODEL1310110012#
name: alcohol dehydrogenase (L-lactaldehyde)

metaR PUNP4
product: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
fast: false
modifier: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Deoxyguanosine)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110012#_b99662b1_06c8_4979_9d13_03d9a3d6695f
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1103
name: CHAT
type: Species
is: Q6LEN6
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM HC01406 m
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: 3-Oxooctanoyl-CoA
constant: false
is: CHEBI:28264
has only substance units: false
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267

http://identifiers.org/biomodels.db/MODEL1310110012#_8d156823_85cf_4daa_8781_ea1bee315a21
name: GUCY1B2:GUCY1A3
is: SBO:0000297
initial amount: NaN
type: Species
has part: D6RDW3
boundary condition: true
is encoded by: hsa:2982
initial concentration: NaN
constant: false
is encoded by: hsa:2974
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_f2963158_c0f8_4c35_bb8e_138d300d901b
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1384
has only substance units: false
type: Species
initial concentration: NaN
name: CRAT
initial amount: NaN
constant: false

metaR r1538
is: SBO:0000185
modifier: MODEL1310110012#
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.17.4.1
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
is described by: ECO:0000000
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
reactant: MODEL1310110012#

metaM xylt c
boundary condition: false
is: HMDB02917
constant: false
type: Species
is: SBO:0000247
name: xylitol
initial concentration: 1.0
is: CHEBI:17151
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_17677aaa_8817_405e_8583_ec6fe84490c3
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:79071
name: ELOVL6
has only substance units: false
boundary condition: true
constant: false
is: Q9H5J4

metaR AKR1C1
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1645.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.1.20 Confidence Level: 4 AUTHORS: PMID:8486699 NOTES:NJ
fast: false
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.3.1.20
kinetic law: MODEL1310110012#
name: aldo-keto reductase family 1, member C1 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
is described by: ECO:0000269
reactant: MODEL1310110012#
reversible: false
modifier: MODEL1310110012#

metaR r1648
modifier: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110012#_5cd3a593_753c_4c5c_a952_d5f77576158a
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10317
constant: false
type: Species
has only substance units: false
name: B3GALT5
boundary condition: true

metaM ksi pre28 g
is: SBO:0000247
is: HMDB00175
is: CHEBI:58053
has only substance units: false
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 28
is: C00130
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C213H341N15O176S8X CHARGE: -9

http://identifiers.org/biomodels.db/MODEL1310110012#_2b9c0e5a_184c_46b4_bd89_848776c896ec
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2348
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
name: FOLR1

metaR CYOOm3
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
is: SBO:0000185
type: Reaction
reversible: false
kinetic law: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
name: cytochrome c oxidase, mitochondrial Complex IV
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.9.3.1
product: MODEL1310110012#

metaM lac L c
is: CHEBI:16651
type: Species
is: SBO:0000247
initial amount: NaN
name: (S)-lactate
constant: false
is: HMDB00190
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM ru5p D c
is: SBO:0000247
boundary condition: false
is: HMDB00618
name: D-ribulose 5-phosphate(2-)
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58121
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_0039ba6a_9ab6_44ec_9993_62e376db28d4
name: IDH3B
boundary condition: true
is encoded by: hsa:3420
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_3b5948fe_ad58_417f_a2cc_6ff317c47c41
is: Q9BY32
name: ITPA
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3704
constant: false

metaR HISDC
reversible: false
modifier: MODEL1310110012#
is: SBO:0000176
product: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.28
reactant: MODEL1310110012#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1644.1) or (3067.1) SUBSYSTEM: Histidine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:14466899 NOTES:IF
fast: false
kinetic law: MODEL1310110012#
name: histidine decarboxylase
is version of: http://identifiers.org/ec-code/4.1.1.22

metaM xoldioloneh c
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:2288
has only substance units: false
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
initial amount: NaN
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
boundary condition: false
constant: false
type: Species
is: HMDB06887

http://identifiers.org/biomodels.db/MODEL1310110012#_00adce3b_4824_4871_8470_bef04918bad3
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AI694761
name: _AI694761_1_c
is: SBO:0000252
boundary condition: true
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_9d5ecdcd_6411_4dc2_9a8f_4914f56abd04
is: SBO:0000252
has only substance units: false
type: Species
constant: false
is encoded by: hsa:5538
initial concentration: NaN
name: PPT1
is: Q6FGQ4
boundary condition: true
initial amount: NaN

metaR r1649
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110012#_2cf0ef14_adae_4518_87fa_b763047615bd
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P05187
initial amount: NaN
is encoded by: hsa:250
type: Species
constant: false
name: ALPP
has only substance units: false

metaR BTNt2
reversible: true
reactant: MODEL1310110012#
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110012#
is: SBO:0000185
name: Biotin reversible transport via proton symport
fast: false

metaM ksi pre12 g
name: keratan sulfate I biosynthesis, precursor 12
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
is: HMDB00175
has only substance units: false
initial amount: NaN
is: CHEBI:58053
boundary condition: false
is: SBO:0000247
is: C00130
type: Species
constant: false
initial concentration: 1.0

metaR OCTAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
fast: false
reversible: true
name: Octanoate transport via diffusion
product: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#

metaR C142OHc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradeca dienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_2e5305a3_af82_4ecd_8adf_764fbd303f12
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:79017
is: B8ZZR8
constant: false
name: GGCT

http://identifiers.org/biomodels.db/MODEL1310110012#_f2a7f6cd_ee75_4e3a_bae4_31a05593e985
is: Q9Y633
initial concentration: NaN
is encoded by: hsa:5136
has only substance units: false
name: PDE1A
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true

metaR FAOXC184C163m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C18:4-->C16:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_a901d30f_7f91_45e5_b044_45c729cb1a35
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:55568
name: GALNT10
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_3e33168e_d4c4_4c98_a689_df4bc8807b5b
initial amount: NaN
name: FADS2
initial concentration: NaN
type: Species
is: O95864
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:9415

metaM 3bcrn e
notes: FORMULA: C11H21NO5 CHARGE: 0
type: Species
is: SBO:0000247
name: 3-hydroxy butyryl carnitine
constant: false
initial amount: NaN
is: C14143
has only substance units: false
is: HMDB04047
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_6b9c95f6_e5ae_420d_9ea2_37a7e7bd5523
initial concentration: NaN
is encoded by: hsa:43
constant: false
name: ACHE
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM ipdp x
is: HMDB01347
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
constant: false
name: isopentenyl diphosphate(3-)
is: CHEBI:128769
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species

metaM 5fthf m
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
is: SBO:0000247
is: CHEBI:57457
name: 5-formyltetrahydrofolate(2-)
type: Species
is: HMDB01562
initial amount: NaN
constant: false

metaM ksi deg2 l
is: CHEBI:30825
has only substance units: false
initial amount: NaN
name: keratan sulfate I, degradation product 2
boundary condition: false
is: HMDB00573
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C241H384N17O210S12 CHARGE: -13
type: Species
constant: false

metaR r0480
reactant: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
kinetic law: MODEL1310110012#
fast: false
is described by: ECO:0000000
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is: SBO:0000176
reversible: true
type: Reaction

metaR NTD5
fast: false
is: SBO:0000176
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:4291247 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Not clear whether it is cytosolic but enzymes in this metabolism often are
product: MODEL1310110012#
is described by: ECO:0000134
reactant: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
name: 5'-nucleotidase (dTMP)
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.5

metaR NRVNCCOAtx
product: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
reversible: true
name: fatty acid intracellular transport
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR TTDCAtr
name: tetradecanoate (transport)
fast: false
kinetic law: MODEL1310110012#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
reactant: MODEL1310110012#
product: MODEL1310110012#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110012#_d6c26b6c_0d6c_4d2d_8d56_ac4d732ec51b
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
name: FOLR1
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2348

metaR FK
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
product: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
type: Reaction
reversible: false
name: Fucokinase
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.52

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaR r1646
product: MODEL1310110012#
reversible: true
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110012#

metaR RDH3
fast: false
is: SBO:0000176
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
name: retinol dehydrogenase (11-cis,NADH)
product: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.1.1.315

metaR OMEPRAZOLEte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
is: SBO:0000185
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110012#
name: xenobiotic transport
type: Reaction
reversible: true

metaR PYDXNK
product: MODEL1310110012#
is described by: ECO:0000269
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.1.35
fast: false
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reactant: MODEL1310110012#
type: Reaction
reversible: false
name: pyridoxine kinase
kinetic law: MODEL1310110012#

metaM gluside hs r
is: SBO:0000247
initial amount: NaN
is: CHEBI:18368
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
name: D-glucosyl-N-acylsphingosine
boundary condition: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190

metaR TSTSTERONEt
is described by: ECO:0000269
name: Testosterone transport
product: MODEL1310110012#
fast: false
type: Reaction
kinetic law: MODEL1310110012#
reversible: true
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
is: SBO:0000185

metaR LTA4H
is version of: http://identifiers.org/ec-code/3.3.2.6
type: Reaction
modifier: MODEL1310110012#
reversible: false
kinetic law: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
reactant: MODEL1310110012#
is: SBO:0000176
product: MODEL1310110012#
is described by: ECO:0000134
name: Leukotriene A-4 hydrolase

http://identifiers.org/biomodels.db/MODEL1310110012#_d9e93e4b_3e94_4bcc_b618_72487728521b
initial concentration: NaN
is: SBO:0000252
name: LDHAL6A
type: Species
boundary condition: true
is: Q6ZMR3
constant: false
is encoded by: hsa:160287
has only substance units: false
initial amount: NaN

metaR PROIMINOtc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Proline by the apical IMINO amino acid transporters in kidney and intestine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_79285336_1270_4d4c_96e2_052973f9017e
is encoded by: hsa:5213
initial amount: NaN
constant: false
is: SBO:0000297
has only substance units: false
has part: P08237
name: PFKM:PFKP
type: Species
boundary condition: true
initial concentration: NaN

metaM od2coa m
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h18-19,26-28,32-34,38,49-50H,4-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b19-18+/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE2244
is: CHEBI:50570
initial concentration: 1.0
type: Species
has only substance units: false
name: trans-Octadec-2-enoyl-CoA
is: HMDB06529
boundary condition: false

metaR CERT1rt
reactant: MODEL1310110012#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
modifier: MODEL1310110012#
reversible: true
fast: false
name: ceramide transport protein
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
product: MODEL1310110012#
is: SBO:0000185
kinetic law: MODEL1310110012#

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaR r0483
is described by: ECO:0000000
reactant: MODEL1310110012#
is: SBO:0000176
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
reversible: true
type: Reaction
product: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110012#_45bd3a28_2098_4bbe_95f9_dad829b68497
is: SBO:0000252
has only substance units: false
is encoded by: hsa:125965
type: Species
boundary condition: true
initial amount: NaN
is: Q6YFQ2
initial concentration: NaN
constant: false
name: COX6B2

metaR G14T19g
product: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110012#
type: Reaction
reversible: false
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is: SBO:0000176
kinetic law: MODEL1310110012#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38

http://identifiers.org/biomodels.db/MODEL1310110012#_9c08c3de_badd_469e_b044_7b8c5b0c385f
constant: false
is: Q8TEQ8
initial concentration: NaN
is encoded by: hsa:84720
initial amount: NaN
boundary condition: true
name: PIGO
has only substance units: false
type: Species
is: SBO:0000252

metaR GNDer
reactant: MODEL1310110012#
reversible: false
is described by: ECO:0000000
type: Reaction
name: phosphogluconate dehydrogenase, endoplasmic reticulum
is: SBO:0000176
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
fast: false
kinetic law: MODEL1310110012#

metaR PUNP1
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false
name: purine-nucleoside phosphorylase (Adenosine)
reversible: true
type: Reaction
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110012#_24d0892d_c245_428b_9c6a_c80811950592
has only substance units: false
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is: P04075
name: ALDOA
is encoded by: hsa:226
initial concentration: NaN

metaM tddedi2coa m
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00792
constant: false
is: C08277
type: Species
name: trans2,6dodecadienoylcoa
initial amount: NaN

metaR PROt4
is: SBO:0000185
name: Na+/Proline-L symporter
reversible: false
product: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (55089.1) or (81539.1) or (54407.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110012#

metaR r1647
is: SBO:0000185
reversible: true
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_eafa6424_1e77_4dff_845e_0955fa31d4f0
is encoded by: hsa:476
is: B7Z3U6
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: ATP1A1
initial concentration: NaN

metaR C12DCACOT
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of dodecanedioyl coa for release into cytosol
type: Reaction

metaM ksii core4 pre9 g
name: keratan sulfate II biosynthesis, precursor 9
constant: false
boundary condition: false
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
is: CHEBI:28067
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN

metaR MANt4
name: D-mannose transport via sodium cotransport
is: SBO:0000185
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110012#
type: Reaction
modifier: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
reversible: true

metaR DCTPtn
fast: false
product: MODEL1310110012#
name: dCTP diffusion in nucleus
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110012#
is described by: ECO:0000000
reactant: MODEL1310110012#
is: SBO:0000185

metaR UGLT
is described by: ECO:0000000
name: UDPglucose--hexose-1-phosphate uridylyltransferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.12
kinetic law: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
product: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
fast: false
reversible: true

metaR SPHS1Pte
kinetic law: MODEL1310110012#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
name: sphingosine-1-phosphate transport
type: Reaction
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
product: MODEL1310110012#

metaM 3bcrn c
notes: FORMULA: C11H21NO5 CHARGE: 0
is: HMDB04047
type: Species
is: SBO:0000247
name: 3-hydroxy butyryl carnitine
has only substance units: false
is: C14143
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR NTD3
fast: false
name: 5'-nucleotidase (dCMP)
modifier: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000176
kinetic law: MODEL1310110012#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
notes: GENE_ASSOCIATION: (93034.1) or (30833.1) or (93034.2) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31

metaM 5forthf c
type: Species
name: 5-Formiminotetrahydrofolate
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB01534
is: C00664
initial concentration: 1.0
is: CHEBI:57456
constant: false
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664

metaR r0377
fast: false
kinetic law: MODEL1310110012#
is described by: ECO:0000000
product: MODEL1310110012#
is: SBO:0000176
reactant: MODEL1310110012#
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
modifier: MODEL1310110012#
reversible: false
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_14664e76_c7bf_4117_aede_b50adc7182d5
boundary condition: true
has only substance units: false
is: E9PCP2
is: SBO:0000252
type: Species
initial amount: NaN
name: CPT1B
is encoded by: hsa:1375
constant: false
initial concentration: NaN

metaM ser D c
has only substance units: false
initial concentration: 1.0
constant: false
name: D-serine
boundary condition: false
is: CHEBI:16523
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB03406

metaR ASPte
product: MODEL1310110012#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110012#
type: Reaction
name: diffusion of aspartate into blood
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. no such transporter could be found so diffusion reaction is assumed. NOTES:
is described by: ECO:0000134
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_7667062d_4f10_4b11_8f8b_e188463aaa21
type: Species
is encoded by: hsa:11041
initial amount: NaN
has only substance units: false
is: O43505
boundary condition: true
name: B3GNT1
is: SBO:0000252
constant: false
initial concentration: NaN

metaR r1644
reactant: MODEL1310110012#
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_639eb932_c826_4637_8338_4ad12786caf8
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2222
constant: false
boundary condition: true
is: P37268
name: FDFT1
type: Species
is: SBO:0000252
initial amount: NaN

metaM octdececoa c
boundary condition: false
constant: false
is: HMDB06351
initial amount: NaN
type: Species
is: SBO:0000247
name: octadecenoylcoa
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4

metaM ei11ecoa x
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
type: Species
has only substance units: false
name: 11-eicosenoylcoa
is: http://identifiers.org/pubchem.compound/24892790
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_7ade42ad_64ef_4c44_afa2_6241c8aee022
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:205
name: AK4
type: Species
boundary condition: true
is: SBO:0000252

metaR EX CE4722 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-casomorphin (1-6) exchange
type: Reaction

metaR BACCL
type: Reaction
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
reactant: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110012#
modifier: MODEL1310110012#
name: biotin-[acetyl-CoA-carboxylase] ligase
reversible: false
is version of: http://identifiers.org/ec-code/6.3.4.10

metaM HC00319 c
type: Species
initial amount: NaN
is: CHEBI:30794
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
name: Malonate

metaR TETPENT6COAtx
is: SBO:0000185
name: fatty acid intracellular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
kinetic law: MODEL1310110012#
is described by: ECO:0000000
reactant: MODEL1310110012#
reversible: true
product: MODEL1310110012#

metaR OCT11EFATP
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of vaccenic acid by cells
type: Reaction

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

metaR RE1447N
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
is: SBO:0000176
name: RE1447
type: Reaction
product: MODEL1310110012#
is described by: ECO:0000000
fast: false
reversible: true

metaR r1645
kinetic law: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
modifier: MODEL1310110012#
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110012#
product: MODEL1310110012#

metaR NACHEX20ly
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110012#_d7274a1a_0559_4dde_b046_ae2e7cc19d7b
has only substance units: false
constant: false
type: Species
is: P00326
initial concentration: NaN
is: SBO:0000252
name: ADH1C
boundary condition: true
is encoded by: hsa:126
initial amount: NaN

metaR 3MOPt2im
is described by: ECO:0000000
fast: false
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110012#
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
reversible: false

metaR RIBt
type: Reaction
kinetic law: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
product: MODEL1310110012#
reactant: MODEL1310110012#
name: ribose transport via diffusion
reversible: true
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110012#_e797fb8d_c3f1_4101_a069_c2adaa6858ed
name: SLC7A6
constant: false
is encoded by: hsa:9057
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q92536
type: Species
initial concentration: NaN
initial amount: NaN

metaR NTD9
name: 5'-nucleotidase (GMP)
product: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
modifier: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_8447c179_d3b8_42d6_abbf_61163980e444
is encoded by: hsa:5152
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: PDE9A
has only substance units: false
type: Species
is: SBO:0000252

metaM eicostetcrn c
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
has only substance units: false
initial concentration: 1.0
is: HMDB01356
is: CHEBI:57312
boundary condition: false
constant: false
initial amount: NaN
name: Eicosatetranoyl carnitine
is: SBO:0000247
type: Species

metaM HC00695 m
is: CHEBI:17432
boundary condition: false
type: Species
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: S-Succinyldihydrolipoamide
initial amount: NaN
constant: false

metaR SERASNNaEx
product: MODEL1310110012#
is: SBO:0000185
name: L-serine/L-asparagine Na-dependent exchange (Ser-L in)
modifier: MODEL1310110012#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
reversible: false

metaM ser D e
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB03406
name: D-serine
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:16523
boundary condition: false

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_a33273c2_0c56_4a3f_9ac3_a42d775272be
boundary condition: true
type: Species
is: SBO:0000252
is: P31939
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:471
constant: false
has only substance units: false
name: ATIC

metaM C05280 m
boundary condition: false
name: cis,cis-3,6-Dodecadienoyl-CoA
is: HMDB03952
type: Species
constant: false
initial amount: NaN
is: CHEBI:28002
has only substance units: false
is: SBO:0000247
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
initial concentration: 1.0

metaR RE1447M
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
reversible: true
name: RE1447
product: MODEL1310110012#
fast: false
is: SBO:0000176
modifier: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.41
kinetic law: MODEL1310110012#
is described by: ECO:0000000
reactant: MODEL1310110012#

metaM lac L e
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB00190
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: CHEBI:16651
name: (S)-lactate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_3ecd37d5_ea2c_456c_b751_9d3a69b8e216
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:55089
constant: false
is: Q969I6
has only substance units: false
name: SLC38A4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_4a0ff228_a152_4eda_92a8_ca29a0e7dc5d
is: Q53G02
is encoded by: hsa:1603
type: Species
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: DAD1

metaR r1642
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
modifier: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110012#_9d126acb_7a5a_4bbd_a754_5da697fe5b70
is: P78381
is encoded by: hsa:7355
name: SLC35A2
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR NTD8
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110012#
fast: false
reversible: false
modifier: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110012#
name: 5'-nucleotidase (dGMP)
type: Reaction
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (22978.1) or (30833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31

metaM lald L c
is: SBO:0000247
is: CHEBI:18041
type: Species
has only substance units: false
is: HMDB03052
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: (S)-lactaldehyde
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110012#_2a30c294_ce06_4f46_893e_6bd431d3a0db
has part: Q96I99
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
name: SUCLG2:SUCLG1
constant: false
is: SBO:0000297
has part: P53597
is encoded by: hsa:8802
initial amount: NaN
is encoded by: hsa:8801

metaM cit c
is: HMDB00094
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial amount: NaN
is: CHEBI:16947
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: Citrate
boundary condition: false
is: C00158

metaR CYSTALArBATtc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Cystine into the cell in exchange for L-Alanine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_b7345d43_5b33_4d68_b684_87a02991d250
is: F5GZG6
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:27010
has only substance units: false
constant: false
type: Species
name: TPK1

metaR LACZe
reversible: false
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase
modifier: MODEL1310110012#
product: MODEL1310110012#
name: b-galactosidase, extracellular
reactant: MODEL1310110012#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.108
kinetic law: MODEL1310110012#

metaR MALSO3tm
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
modifier: MODEL1310110012#
name: Malate:sulfite antiport, mitochondrial
is described by: ECO:0000269
kinetic law: MODEL1310110012#
product: MODEL1310110012#
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110012#

metaM 3ddcrn c
type: Species
is: HMDB00623
constant: false
notes: FORMULA: C19H37NO5 CHARGE: 0
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 3-hydroxydodecanoylcarnitine

metaR URATEt
reactant: MODEL1310110012#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
type: Reaction
product: MODEL1310110012#
is: SBO:0000185
name: urate export from cytosol
kinetic law: MODEL1310110012#

metaR r1643
modifier: MODEL1310110012#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
product: MODEL1310110012#
is described by: ECO:0000000
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110012#_a9611485_b3f0_46c0_b6b1_107e4cdbe08a
type: Species
boundary condition: true
is: Q53YE7
initial concentration: NaN
constant: false
is encoded by: hsa:4128
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: MAOA

http://identifiers.org/biomodels.db/MODEL1310110012#_2bedcb25_0366_4819_a5b5_2d31a32dba6a
boundary condition: true
is: Q6IBB5
name: NDUFA1
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:4694
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_7a695eda_975b_4e55_8c7c_f841f1907c43
is encoded by: hsa:50
is: SBO:0000252
initial concentration: NaN
name: ACO2
initial amount: NaN
boundary condition: true
is: Q99798
type: Species
has only substance units: false
constant: false

metaR DNDPt17m
is: SBO:0000185
kinetic law: MODEL1310110012#
type: Reaction
fast: false
reversible: false
is described by: ECO:0000269
product: MODEL1310110012#
modifier: MODEL1310110012#
name: dUDP transport via dCDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110012#

metaM ksi pre10 g
has only substance units: false
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
initial concentration: 1.0
is: HMDB00175
boundary condition: false
initial amount: NaN
is: C00130
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 10
is: SBO:0000247
constant: false
type: Species

metaR NTD7
product: MODEL1310110012#
modifier: MODEL1310110012#
name: 5'-nucleotidase (AMP)
is: SBO:0000176
reversible: false
reactant: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110012#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110012#_f3a50947_78c5_41bd_aed1_b3e91e17404e
constant: false
is encoded by: hsa:6567
is: SBO:0000252
has only substance units: false
name: SLC16A2
boundary condition: true
initial concentration: NaN
is: P36021
type: Species
initial amount: NaN

metaM CE4872 c
boundary condition: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
initial concentration: 1.0
type: Species
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
constant: false
is: CHEBI:15748
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB00127

metaR EX limnen LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Limonene exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_b5ac214a_78cc_4bea_afad_99b831a6ac7c
is: SBO:0000252
has only substance units: false
type: Species
is: Q3MHC9
boundary condition: true
is encoded by: hsa:23517
constant: false
name: SKIV2L2
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_51bb10cb_3063_4fac_86b8_a20b91a9f784
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P40926
type: Species
constant: false
is: SBO:0000252
has only substance units: false
name: MDH2
is encoded by: hsa:4191

metaR C140CPT1
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of myristoylcarnitine
type: Reaction

metaR FAOXC103C102x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)x
type: Reaction

metaM retinol cis 11 c
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
name: 11-cis-retinol
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: CHEBI:16302
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB06216

metaR r0157
is described by: ECO:0000000
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/6.3.4.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
kinetic law: MODEL1310110012#
reversible: false
reactant: MODEL1310110012#
product: MODEL1310110012#
fast: false
type: Reaction

metaR r1641
fast: false
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM btamp m
boundary condition: false
is: SBO:0000247
constant: false
type: Species
name: Biotinyl-5'-AMP
initial concentration: 1.0
is: CHEBI:3110
initial amount: NaN
is: HMDB04220
has only substance units: false
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921

metaR NDPK1m
kinetic law: MODEL1310110012#
is: SBO:0000176
fast: false
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
type: Reaction
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000254
reversible: true

metaM 5hoxindact c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H9NO2 CHARGE: 0 INCHI: InChI=1S/C10H9NO2/c12-4-3-7-6-11-10-2-1-8(13)5-9(7)10/h1-2,4-6,11,13H,3H2 HEPATONET_1.0_ABBREVIATION: HC01536 EHMN_ABBREVIATION: C05634
initial concentration: 1.0
boundary condition: false
is: HMDB04073
name: (5-hydroxyindol-3-yl)acetaldehyde
type: Species
constant: false
initial amount: NaN
is: CHEBI:50157

http://identifiers.org/biomodels.db/MODEL1310110012#_36caf6c2_bf98_4c36_aaab_8195121f6c53
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR RE3524R
name: RE3524
reactant: MODEL1310110012#
is: SBO:0000176
kinetic law: MODEL1310110012#
reversible: true
type: Reaction
product: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110012#_7fb717b4_fab5_4f8e_afea_8c118c750060
initial amount: NaN
is encoded by: hsa:51004
name: COQ6
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: Q9Y2Z9
boundary condition: true

metaM 3ddcrn e
is: SBO:0000247
type: Species
is: HMDB00791
boundary condition: false
is: C02838
notes: FORMULA: C19H37NO5 CHARGE: 0
constant: false
has only substance units: false
initial concentration: 1.0
name: 3-hydroxydodecanoylcarnitine
initial amount: NaN

metaM em2emgacpail hs r
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
type: Species
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
is: HMDB03125
constant: false
is: CHEBI:16240

metaM ocdca e
has only substance units: false
type: Species
name: octadecanoate (n-C18:0)
boundary condition: false
is: HMDB00827
is: SBO:0000247
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
is: C01530
is: CHEBI:25629
constant: false
initial amount: NaN
initial concentration: 1.0

metaM C05965 e
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: HMDB04243
is: SBO:0000247
initial concentration: 1.0
name: 12(S)-HPETE(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
is: CHEBI:57444

metaR CYTK1m
kinetic law: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
reversible: true
type: Reaction
is described by: ECO:0000134
name: cytidylate kinase (CMP),mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110012#_a03e813b_245e_42de_b328_aaf055cfcc4a
constant: false
is: SBO:0000252
name: SMS
boundary condition: true
has only substance units: false
is: P52788
is encoded by: hsa:6611
type: Species
initial concentration: NaN
initial amount: NaN

metaM ksii core2 deg2 l
initial amount: NaN
initial concentration: 1.0
is: CHEBI:12936
boundary condition: false
has only substance units: false
constant: false
is: HMDB00143
name: keratan sulfate II (core 2-linked), degradation product 2
type: Species
is: SBO:0000247
notes: FORMULA: C70H114N5O56S2X CHARGE: -2

metaM tag1p D c
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1/C6H13O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h3,5-8,10-11H,1-2H2,(H2,12,13,14)/t3-,5+,6-/m1/s1
has only substance units: false
is: HMDB06328
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
name: D-Tagatose 1-phosphate
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_158d8ff3_7851_4ff4_9e70_d9f464eb158b
constant: false
type: Species
name: ESCO2
boundary condition: true
is: Q56NI9
is encoded by: hsa:157570
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR r1640
modifier: MODEL1310110012#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110012#
reversible: true
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110012#_6198884f_6a1d_4069_9b8f_eaf4dd51cd94
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: RDH16
is: O75452
is encoded by: hsa:8608

metaM CE0849 m
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57795
has only substance units: false
constant: false
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
name: cis,cis-palmito-7,10-dienoyl-CoA
boundary condition: false

metaR sink tetdece1coa LPAREN c RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDECE1COASINK
type: Reaction

metaM retinol cis 11 e
constant: false
name: 11-cis-retinol
initial amount: NaN
is: HMDB06216
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: CHEBI:16302
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_ac41bfe9_0ea9_4a48_bf3b_ad1cd1b5bbb7
initial concentration: NaN
is encoded by: hsa:79053
has only substance units: false
is: A6NDW6
type: Species
initial amount: NaN
constant: false
boundary condition: true
name: ALG8
is: SBO:0000252

metaM octdececoa m
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280355
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
type: Species
name: octadecenoylcoa
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4

metaR CHOLtu
kinetic law: MODEL1310110012#
type: Reaction
name: Choline uniport
reversible: true
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
is: SBO:0000185
fast: false
is described by: ECO:0000269
product: MODEL1310110012#
reactant: MODEL1310110012#

metaR SEBCOAPET
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

metaM hs deg13 l
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
constant: false
has only substance units: false
is: HMDB06210
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
name: heparan sulfate, degradation product 13
boundary condition: false

metaM din c
name: Deoxyinosine
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:28997
is: C05512
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: HMDB00071

metaM 3hdcoa m
boundary condition: false
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
name: (S)-3-Hydroxydecanoyl-CoA
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_20689759_026d_4f35_bd90_85e348673657
type: Species
boundary condition: true
is encoded by: hsa:518
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: ATP5G3

metaM mi1p D c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
name: 1D-myo-inositol 1-phosphate(2-)
type: Species
is: CHEBI:58433
is: HMDB02985

http://identifiers.org/biomodels.db/MODEL1310110012#_69f8a802_dd7f_4300_8a6d_b64460c9a1fe
name: SLC46A1
is: Q96NT5
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:113235
has only substance units: false

metaR C10DCc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_5e826c23_dde5_40fa_a66f_f521abb4b99a
name: NME7
constant: false
initial amount: NaN
has only substance units: false
is: Q9Y5B8
type: Species
is encoded by: hsa:29922
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_41c76298_ddce_4a9a_8271_88642b1559ed
constant: false
is encoded by: hsa:57282
type: Species
boundary condition: true
is: B7Z1R0
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: SLC4A10
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_1f9bb41f_1a5c_48f1_83f9_6bc18547f23c
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10841
constant: false
has only substance units: false
initial amount: NaN
name: FTCD
is: SBO:0000252

metaR NDPK1n
kinetic law: MODEL1310110012#
is described by: ECO:0000134
reactant: MODEL1310110012#
reversible: true
is: SBO:0000176
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110012#
fast: false
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear

metaR FADtx
product: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
reversible: true
name: FAD transporter, peroxisomal
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_3ffe8fc9_b9d2_4c7f_a8df_e020fea4921d
initial concentration: NaN
name: SLC24A4
has only substance units: false
is encoded by: hsa:123041
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252

metaM glu5p m
constant: false
initial amount: NaN
is: CHEBI:58274
is: HMDB01228
name: L-Glutamate 5-phosphate
notes: FORMULA: C5H8NO7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01092 EHMN_ABBREVIATION: C03287
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false

metaR RE3346C
name: RE3346
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
product: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
modifier: MODEL1310110012#

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_c7121155_ff38_4503_ae3b_f750eb400122
type: Species
name: GCH1
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:2643
boundary condition: true
initial amount: NaN
is: Q8IZH9
has only substance units: false

metaR CSNAT2m
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.7
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000176
product: MODEL1310110012#
is described by: ECO:0000000
type: Reaction
name: carnitine O-aceyltransferase, mitochondrial
modifier: MODEL1310110012#

metaR HSD11B2r
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.1.1.146
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (3291.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
modifier: MODEL1310110012#
reversible: true
kinetic law: MODEL1310110012#
fast: false
is: SBO:0000176
is described by: ECO:0000269
name: 11-beta-hydroxysteroid dehydrogenase type 2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_313948b4_eda8_4283_80ab_9066253e5b37
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:2687
is: P36269
name: GGT5
constant: false
initial concentration: NaN

metaR C3STDH1Pr
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110012#
name: C-3 sterol dehydrogenase (4-methylzymosterol)
is version of: http://identifiers.org/ec-code/1.1.1.170
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
modifier: MODEL1310110012#

metaR FAOXC16DCr
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

metaM gtp n
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial concentration: 1.0
boundary condition: false
is: CHEBI:37565
initial amount: NaN
is: HMDB01273
is: SBO:0000247
has only substance units: false
name: GTP(4-)
type: Species
constant: false

metaM 5mta e
type: Species
is: C00170
is: CHEBI:17509
is: HMDB01173
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C11H15N5O3S CHARGE: 0
initial amount: NaN
initial concentration: 1.0
name: 5-Methylthioadenosine

metaM ump n
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57865
type: Species
name: UMP(2-)

metaM din e
is: SBO:0000247
type: Species
is: CHEBI:28997
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: Deoxyinosine
is: HMDB00071
is: C05512
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
has only substance units: false

metaR RDH1
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
kinetic law: MODEL1310110012#
name: retinol dehydrogenase (all-trans)
type: Reaction
is described by: ECO:0000269
reversible: true
product: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.1.1.315
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110012#_93dc8beb_7296_4bad_b94b_e32da88cf477
is encoded by: hsa:1558
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: CYP2C8
is: P10632
type: Species
has only substance units: false
initial concentration: NaN

metaM glygn5 e
notes: FORMULA: C12H21O11X CHARGE: 0
has only substance units: false
name: glycogen, structure 5 (glycogenin-2[1,4-Glc])
boundary condition: false
initial amount: NaN
is: C00116
constant: false
is: CHEBI:17754
is: HMDB00131
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM CE5788 e
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: HMDB02710
name: kinetensin 1-7
is: SBO:0000247
constant: false
is: CHEBI:27485

http://identifiers.org/biomodels.db/MODEL1310110012#_a41e0649_082d_4e93_9668_3a4be6fb7e38
initial concentration: NaN
initial amount: NaN
is: Q96N66
is: SBO:0000252
name: MBOAT7
boundary condition: true
has only substance units: false
constant: false
type: Species
is encoded by: hsa:79143

metaR SUCD1m
product: MODEL1310110012#
name: succinate dehydrogenase
fast: false
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.3.5.1
kinetic law: MODEL1310110012#
type: Reaction
reversible: true
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic

http://identifiers.org/biomodels.db/MODEL1310110012#_f5caebe9_924e_4915_b9ea_6957a2f36ee5
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q5JAM2
is: SBO:0000252
type: Species
name: ALAS1
is encoded by: hsa:211
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_a9fbcf1d_27ee_4f2f_b5a4_6cb97997d94e
is encoded by: hsa:1607
initial amount: NaN
initial concentration: NaN
name: DGKB
has only substance units: false
type: Species
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_d97fcbde_bbf7_4822_8e01_3255fa321691
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:5213
is: SBO:0000252
has only substance units: false
name: PFKM
boundary condition: true
initial amount: NaN
is: P08237

http://identifiers.org/biomodels.db/MODEL1310110012#_b370661e_0c57_494d_8585_95463b8e781e
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: SOD2
constant: false
is encoded by: hsa:6648
initial amount: NaN
boundary condition: true
type: Species
is: P04179

metaM c226coa c
is: C16169
is: SBO:0000247
name: cervonyl coenzyme A
initial concentration: 1.0
constant: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
has only substance units: false
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/47205479
boundary condition: false

metaR ACACT1r
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: true
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
product: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
fast: false
name: acetyl-CoA C-acetyltransferase
is: SBO:0000176
is described by: ECO:0000000

metaR ELAIDCRNt
is: SBO:0000185
kinetic law: MODEL1310110012#
reversible: false
is described by: ECO:0000000
type: Reaction
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
product: MODEL1310110012#

metaR HPETFABP1tc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 5-HPETE into the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_d1c44e1f_c94b_473d_8089_d4fe26bb1d15
name: QPRT
is encoded by: hsa:23475
is: Q15274
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaR CHOLtr
name: choline intracellular transport
type: Reaction
product: MODEL1310110012#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110012#
is: SBO:0000185
reversible: true
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ

metaM CE5101 m
has only substance units: false
is: SBO:0000247
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
constant: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:57795

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

metaM c8dc x
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
name: suberyl carnitine
notes: FORMULA: C15H26NO6 CHARGE: -1
has only substance units: false
boundary condition: false
is: HMDB00893
constant: false

metaM 5mta c
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
is: C00170
is: SBO:0000247
is: CHEBI:17509
is: HMDB01173
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
name: 5-Methylthioadenosine
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_d6068f08_e2b9_4bec_8745_787440cbb78e
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is: Q16790
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:768
name: CA9

http://identifiers.org/biomodels.db/MODEL1310110012#_e9da1084_4571_498a_9880_b930f4c1791b
name: CHST6
initial concentration: NaN
type: Species
is encoded by: hsa:4166
is: Q9GZX3
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false

metaR PTDCACRNt
product: MODEL1310110012#
fast: false
type: Reaction
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000000
reversible: false
name: pentadecanoate transport into the mitochondria
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
reactant: MODEL1310110012#

metaR RE1254C
is: SBO:0000176
product: MODEL1310110012#
is described by: ECO:0000000
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
name: RE1254
kinetic law: MODEL1310110012#
type: Reaction
fast: false
reversible: true

metaR C142OHe
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:2-OH
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_871d2f58_1ed1_4e63_ac71_a7aa1ff2dcf7
name: GLS2
is: Q9UI32
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:27165

metaM 3hibutcoa m
boundary condition: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
initial amount: NaN
is: HMDB01052
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
name: (S)-3-Hydroxyisobutyryl-CoA
is: CHEBI:28259
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_2e96109d_5b4e_4dc0_a4a2_750ad472129e
type: Species
boundary condition: true
initial concentration: NaN
constant: false
name: CHKA
initial amount: NaN
is: P35790
has only substance units: false
is encoded by: hsa:1119
is: SBO:0000252

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaM gtp m
type: Species
is: CHEBI:37565
constant: false
initial concentration: 1.0
name: GTP
boundary condition: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial amount: NaN
is: HMDB01273
has only substance units: false
is: SBO:0000247
is: C00044

metaR MAGt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:10344773 NOTES:
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000269
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110012#
name: monoacylglycerol 2 transport

metaM thcholstoic c
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: SBO:0000247
is: CHEBI:18402
type: Species
initial amount: NaN
is: HMDB03873

http://identifiers.org/biomodels.db/MODEL1310110012#_facd0cf2_77cf_45b0_be1a_9d6ba10faee8
initial concentration: NaN
is encoded by: hsa:9563
is: O95479
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
name: H6PD
constant: false

metaM ump r
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00288
name: UMP

metaM eicostetcrn m
type: Species
is: HMDB01356
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
name: Eicosatetranoyl carnitine
boundary condition: false
is: CHEBI:57312

metaM gpi prot hs r
is: CHEBI:7896
is: SBO:0000247
type: Species
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2X CHARGE: 0
name: {[(Prot-PE-Man),(PE)-Man],[PE]}-Man-GlcN-acylPI
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: C00249
is: HMDB00220
constant: false

metaM gluside hs c
initial concentration: 1.0
is: CHEBI:18368
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
is: SBO:0000247
type: Species
boundary condition: false
constant: false
initial amount: NaN
name: D-glucosyl-N-acylsphingosine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_g
boundary condition: false
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:61648
initial concentration: 1.0
name: Type IIIAb
is: SBO:0000247

metaR TDCHOLAtx
product: MODEL1310110012#
fast: false
name: bile acid intracellular transport
is: SBO:0000185
type: Reaction
reactant: MODEL1310110012#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110012#

metaR BILGLCURtr
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
name: glucuronidated compound transport
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110012#
fast: false
type: Reaction
product: MODEL1310110012#
is: SBO:0000185

metaR r1453
reversible: true
type: Reaction
reactant: MODEL1310110012#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
product: MODEL1310110012#
is: SBO:0000176
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_f9dc0f1b_2831_4e2f_ab9d_d197af01e7ac
has only substance units: false
name: SLC25A26
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:115286
initial concentration: NaN
constant: false
initial amount: NaN
is: Q70HW3

metaR GALASE5ly
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110012#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
product: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110012#

metaR 1PPDCRp
name: delta1-piperideine-2-carboxylate reductase, perixosomal
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
reversible: false
is: SBO:0000176
product: MODEL1310110012#
is described by: ECO:0000000
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_4fb38d72_3aa3_4483_b99d_6b3d77e4022f
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:1544
boundary condition: true
name: CYP1A2
initial amount: NaN
is: P05177

metaM 3hdcoa c
boundary condition: false
type: Species
initial concentration: 1.0
name: (S)-3-Hydroxydecanoyl-CoA
initial amount: NaN
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
is: HMDB00651
constant: false
has only substance units: false
is: SBO:0000247

metaM 6hoxmelatn c
is: http://identifiers.org/pubchem.compound/7954
initial amount: NaN
notes: FORMULA: C13H16N2O3 CHARGE: 0 INCHI: InChI=1/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C05643
constant: false
name: 6-Hydroxymelatonin
is: HMDB04081
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: C05643
initial concentration: 1.0

metaR 34HPLFM
type: Reaction
product: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
name: 3-(4-hydroxyphenyl-)lactate formation
reversible: false
kinetic law: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaR PROSTGI2t
type: Reaction
reactant: MODEL1310110012#
name: Prostaglandin I2 transport
reversible: true
product: MODEL1310110012#
is: SBO:0000185
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
fast: false
is described by: ECO:0000269

metaR DCK2n
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.1.74
name: Deoxycytidine kinase, nuclear (UTP)
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
fast: false
product: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
is described by: ECO:0000269

metaR C4STMO2r
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
type: Reaction
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.14.13.72
name: C-4 methyl sterol oxidase
is described by: ECO:0000000
reversible: false
fast: false
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.1.1.170
is: SBO:0000176
reactant: MODEL1310110012#
product: MODEL1310110012#

metaM l2n2m2mn l
constant: false
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
is: HMDB00143
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:12936
notes: FORMULA: C54H91N3O41 CHARGE: 0
initial amount: NaN
boundary condition: false

metaR DITPtn
fast: false
name: dITP nuclear transport
kinetic law: MODEL1310110012#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110012#

metaR CHOLtn
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
kinetic law: MODEL1310110012#
type: Reaction
name: Choline transport, nuclear through pores
is: SBO:0000185
reactant: MODEL1310110012#
is described by: ECO:0000000
product: MODEL1310110012#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110012#_e0986d27_af8d_4385_8fb2_661e8fb05b2c
initial concentration: NaN
is: P10768
has only substance units: false
is encoded by: hsa:2098
initial amount: NaN
name: ESD
is: SBO:0000252
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_554db063_2832_45ab_9356_264fa6a0f716
initial amount: NaN
is: Q59EA4
boundary condition: true
is: SBO:0000252
name: PLD1
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:5337
constant: false

metaR GLCAASE8ly
modifier: MODEL1310110012#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
name: beta-glucuronidase, lysosomal
reversible: false
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.31
kinetic law: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
fast: false

metaR FAOXC162C162OHm
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:2-->C16:2OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_5920bf5c_b821_4cc3_a834_e58532952121
has part: Q8WYR1
name: PIK3R5:PIK3CG
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:23533
type: Species

metaR FAOXC81C61m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

metaR CYSTHRNaEx
reactant: MODEL1310110012#
reversible: false
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000185
name: L-cysteine/L-threonine Na-dependent exchange (Cys-L in)
product: MODEL1310110012#
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaM c226coa m
is: C16169
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
name: cervonyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205479
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
initial concentration: 1.0
boundary condition: false
type: Species

metaM btamp c
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
is: HMDB04220
boundary condition: false
has only substance units: false
is: CHEBI:3110
name: Biotinyl-5'-AMP
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM bilirub r
boundary condition: false
is: HMDB00054
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
name: bilirubin(2-)
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
type: Species
initial amount: NaN
is: CHEBI:57977

metaR EX ivcrn
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for isovaleryl carnitine
type: Reaction

metaM datp m
is: CHEBI:61404
is: C00131
has only substance units: false
is: HMDB01532
boundary condition: false
initial concentration: 1.0
name: dATP
type: Species
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
constant: false
initial amount: NaN
is: SBO:0000247

metaM ksi pre25 g
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
is: C00130
is: CHEBI:58053
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 25
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_e8c13c90_12ef_4949_b1c2_7a8f5a0d82e5
has only substance units: false
is encoded by: hsa:1607
type: Species
constant: false
is: SBO:0000252
boundary condition: true
name: DGKB
initial concentration: NaN
is: Q9Y6T7
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_a8cbc759_ea44_4140_b854_d9df91fd661e
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10555
is: O15120
name: AGPAT2
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaM ptth m
name: pantetheine
initial amount: NaN
boundary condition: false
constant: false
is: HMDB03426
is: CHEBI:16753
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false

metaR TOLBUTAMIDEte
product: MODEL1310110012#
type: Reaction
name: xenobiotic transport
reactant: MODEL1310110012#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
kinetic law: MODEL1310110012#

metaM crtsl r
notes: FORMULA: C21H30O5 CHARGE: 0 INCHI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00735
is: SBO:0000247
is: CHEBI:17650
constant: false
has only substance units: false
is: HMDB00063
type: Species
boundary condition: false
initial concentration: 1.0
name: cortisol
initial amount: NaN

metaR H5MTer U
name: H5 mannosyltransferase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
fast: false
reversible: false
reactant: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction

metaR S6TASE22ly
modifier: MODEL1310110012#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
name: galactose-6-sulfate sulfatase, lysosomal
reactant: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR BTNPLm
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.10
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
reactant: MODEL1310110012#
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110012#

metaR SCP21x
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
type: Reaction
is described by: ECO:0000269
name: Sterol carrier protein 2
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.176
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
reversible: true
product: MODEL1310110012#
modifier: MODEL1310110012#

metaR DHCHOLESTANATEtm
fast: false
reactant: MODEL1310110012#
name: lipid, flip-flop intracellular transport
is: SBO:0000185
product: MODEL1310110012#
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ

metaR r1454
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110012#
reactant: MODEL1310110012#
reversible: false
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_e42f9922_939a_467a_862e_ddb9b5be10f0
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:4731
name: NDUFV3
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: P56181

metaM datp n
type: Species
is: CHEBI:61404
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
constant: false
initial amount: NaN
is: HMDB01532
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: dATP
is: C00131
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_ea1fddf2_d9ad_4e29_9acc_955c343bc397
name: NT5C3
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:51251
is: SBO:0000252
is: Q9H0P0
initial amount: NaN

metaR TETHEX3t
is described by: ECO:0000000
reversible: true
name: fatty acid transport via diffusion
product: MODEL1310110012#
is: SBO:0000185
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
type: Reaction
reactant: MODEL1310110012#

metaR FAOXC15ATPx
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C15)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_0bd12406_4faf_447a_b9b2_5cb3b2d129df
is: Q9NQ66
name: PLCB1
is encoded by: hsa:23236
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN

metaM 2hb e
type: Species
is: HMDB00008
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
name: 2-Hydroxybutyrate
is: CHEBI:1148
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR 4HOXPACDOX NADP
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000304
product: MODEL1310110012#
reversible: true
reactant: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
type: Reaction
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110012#_7daa9739_0bc5_48e7_8853_fad1174bd46e
has only substance units: false
type: Species
is encoded by: hsa:1351
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: COX8A
is: Q53XN1

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaM gtp e
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
boundary condition: false
constant: false
is: HMDB01273
is: SBO:0000247
is: CHEBI:37565
name: GTP(4-)
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species

metaR GPIAT
is described by: ECO:0000269
name: glucosaminylphosphatidyl inositol acetyltransferase
type: Reaction
product: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
modifier: MODEL1310110012#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110012#

metaR ACGALtlg
type: Reaction
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism - may be vesicular NJ
reversible: true
is: SBO:0000185
product: MODEL1310110012#
name: N-acetyl-galactosamine intracellular transport

metaR S6T8g
fast: false
reversible: false
modifier: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#

metaM HC02214 e
initial concentration: 1.0
has only substance units: false
is: CHEBI:28852
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: prostaglandin-f1alpha

metaM camp c
type: Species
constant: false
boundary condition: false
name: 3',5'-cyclic AMP(1-)
initial concentration: 1.0
is: SBO:0000247
is: HMDB00058
is: CHEBI:58165
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575

http://identifiers.org/biomodels.db/MODEL1310110012#_baef77c1_8da2_4f82_b606_27f4fc7b0dc2
initial concentration: NaN
has part: P04844
is encoded by: hsa:6185
boundary condition: true
name: DAD1:DDOST:RPN1:RPN2
has part: P39656
has part: P04843
is encoded by: hsa:6184
is encoded by: hsa:1650
is: SBO:0000297
has part: Q53G02
type: Species
constant: false
is encoded by: hsa:1603
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_ae0d2ffc_94e9_450e_ae21_78c4f3651af1
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:956
name: ENTPD3
is: O75355
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_54709875_2879_4f07_ad45_fd83ae295128
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: B2RAT6
constant: false
is encoded by: hsa:2592
type: Species
name: GALT
has only substance units: false
initial concentration: NaN

metaM core3 g
boundary condition: false
has only substance units: false
type: Species
name: Core 3
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C16H27N2O10X CHARGE: 0
constant: false
initial concentration: 1.0
is: CHEBI:16250

http://identifiers.org/biomodels.db/MODEL1310110012#_metaM_galacgalfuc12gal14acglcgalgluside_hs_g
name: (Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
has only substance units: false
is: CHEBI:26174
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C64H112N3O36FULLRCO CHARGE: 0
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR RTOTAL3t
is: SBO:0000185
reactant: MODEL1310110012#
product: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
name: RTOTAL3 transport
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_b80a1181_8168_4c0e_b39a_d74ece2125f4
constant: false
initial amount: NaN
has only substance units: false
name: DGKH
is: A8K0I1
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:160851
initial concentration: NaN

metaM ficytC m
is: CHEBI:15991
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
name: Ferricytochrome c
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
initial amount: NaN
type: Species
is: SBO:0000247

metaR EX thmtp LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiamin triphosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_2ef32d59_7d50_4885_bb31_7cac038b1df8
has only substance units: false
type: Species
is encoded by: hsa:4830
is: SBO:0000297
name: NME1:NME2
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true

metaR r0267
is: SBO:0000176
reversible: true
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
kinetic law: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.5.1.9
reactant: MODEL1310110012#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_c
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0
has only substance units: false
boundary condition: false
is: HMDB01659
type: Species
initial amount: NaN
initial concentration: 1.0
name: Type IIIAb
is: CHEBI:15347
constant: false
is: SBO:0000247

metaM c81crn e
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C15H27NO4 CHARGE: 0
initial amount: NaN
name: octenoyl carnitine
is: SBO:0000247
is: HMDB13324

metaR GLUTCOADHm
is version of: http://identifiers.org/ec-code/1.3.99.7
type: Reaction
kinetic law: MODEL1310110012#
name: glutaryl-CoA dehydrogenase (mitochondria)
is described by: ECO:0000304
is: SBO:0000176
reactant: MODEL1310110012#
reversible: false
product: MODEL1310110012#
modifier: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain

metaM 2hb c
initial amount: NaN
boundary condition: false
is: HMDB00008
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
has only substance units: false
initial concentration: 1.0
name: 2-Hydroxybutyrate
is: SBO:0000247
is: CHEBI:1148
constant: false

metaR 2OXOADPTm
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
name: 2-oxoadipate shuttle (cytosol/mitochondria)
type: Reaction
product: MODEL1310110012#
is: SBO:0000185
reversible: true
is described by: ECO:0000269

metaR FAOXC103C102m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_3d0a565c_734d_430c_bec8_a1d3cef1f175
has only substance units: false
initial amount: NaN
boundary condition: true
is: A0PJJ9
name: GGT7
initial concentration: NaN
is encoded by: hsa:2686
type: Species
constant: false
is: SBO:0000252

metaM odecrn m
name: octadecenoyl carnitine
has only substance units: false
type: Species
is: HMDB01114
constant: false
is: CHEBI:57394
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
initial amount: NaN
is: C00412
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_2e4fe172_b162_4415_9a95_68607be6d42f
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q5JZF5
initial amount: NaN
is encoded by: hsa:212
constant: false
initial concentration: NaN
name: ALAS2

http://identifiers.org/biomodels.db/MODEL1310110012#_26f3fbde_6c6c_4842_bfca_0a0ec0400ba8
is: SBO:0000252
type: Species
is: P31350
is encoded by: hsa:6241
boundary condition: true
initial amount: NaN
has only substance units: false
name: RRM2
initial concentration: NaN
constant: false

metaM lac L x
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: (S)-lactate
boundary condition: false
constant: false
is: CHEBI:16651
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: HMDB00190

metaR BILDGLCURt
kinetic law: MODEL1310110012#
is described by: ECO:0000269
modifier: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
reversible: true
product: MODEL1310110012#
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110012#_ab319ea0_521c_45c7_b333_ae0f03fb6983
name: IDH3B
constant: false
type: Species
is: O43837
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3420
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_ca5a03d8_807d_41e2_ba69_50647ffb6427
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: _206_1_c
constant: false
is encoded by: hsa:206
initial concentration: NaN

metaR UAG4E
name: UDP-N-acetylglucosamine 4-epimerase
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/5.1.3.2
fast: false
is: SBO:0000176
reversible: true

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaR r0268
is version of: http://identifiers.org/ec-code/3.1.3.2
fast: false
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
is: SBO:0000176
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
kinetic law: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.1
product: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110012#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_e
is: HMDB01659
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0
has only substance units: false
is: CHEBI:15347
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: Type IIIAb

metaM gtp c
is: C00044
boundary condition: false
is: HMDB01273
constant: false
is: CHEBI:37565
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: GTP

metaR SPHS1Ptr
is: SBO:0000185
type: Reaction
reactant: MODEL1310110012#
reversible: true
fast: false
kinetic law: MODEL1310110012#
name: sphingosine-1-phosphate transport
product: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ

metaR r1756
kinetic law: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
reversible: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110012#
product: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110012#_9f95f451_0c77_4f4d_983a_f38ebb487e4a
is encoded by: hsa:28976
initial amount: NaN
is: Q9H845
has only substance units: false
name: ACAD9
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true

metaM HC02214 c
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: CHEBI:28852
type: Species
boundary condition: false
name: prostaglandin-f1alpha
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_efe2badd_c213_4786_b8c9_7eb0772c29f4
type: Species
is: SBO:0000252
is encoded by: hsa:10400
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
name: PEMT

http://identifiers.org/biomodels.db/MODEL1310110012#_ce3624df_86e9_4cd5_bd39_bb17f1ff95f2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: E9PDD5
is encoded by: hsa:3421
constant: false
boundary condition: true
name: IDH3G
type: Species

metaR r1459
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: Transport reaction
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110012#
reversible: true
type: Reaction
reactant: MODEL1310110012#

metaM cs e deg3 l
notes: FORMULA: C37H53NO44S4 CHARGE: -6
is: CHEBI:15748
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
constant: false
has only substance units: false
boundary condition: false
is: HMDB00127
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM fmn c
type: Species
boundary condition: false
constant: false
is: CHEBI:58210
is: SBO:0000247
initial amount: NaN
name: FMN
is: HMDB01520
has only substance units: false
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
initial concentration: 1.0
is: C00061

metaM adpcoa c
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: C14143
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
has only substance units: false
is: HMDB04047
name: adipoylcoa
constant: false

metaM cspg b l
boundary condition: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
is: HMDB02183
is: SBO:0000247
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
initial concentration: 1.0
has only substance units: false
is: CHEBI:36005
initial amount: NaN
constant: false
type: Species

metaM cs a l
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: false
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
is: CHEBI:36005
is: HMDB02183

metaM pristcoa c
initial amount: NaN
name: pristanoyl coa
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
is: CHEBI:51341
type: Species
boundary condition: false

metaR EX adrn LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adrenic acid exchange
type: Reaction

metaR CYTK1n
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000269
modifier: MODEL1310110012#
name: cytidylate kinase (CMP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
fast: false

metaR CHOLtg
fast: false
type: Reaction
name: choline intracellular transport
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
reversible: true

metaR RE0926E
is described by: ECO:0000000
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.1
reactant: MODEL1310110012#
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.17
type: Reaction
product: MODEL1310110012#
name: RE0926
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:

metaM tetd7ecoa m
is: HMDB13109
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
name: 7-tetradecenoylcoa
has only substance units: false

metaM lnlc r
initial concentration: 1.0
constant: false
name: linoleate
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:30245
is: HMDB00673
boundary condition: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595

http://identifiers.org/biomodels.db/MODEL1310110012#_58f08b15_b7db_4da3_a633_c567ad312099
boundary condition: true
type: Species
constant: false
has only substance units: false
is encoded by: hsa:594
has part: Q9BQL0
initial amount: NaN
name: DBT:DLD:BCKDHA:BCKDHB
is: SBO:0000297
initial concentration: NaN

metaR r0156
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000176
fast: false
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15

metaR 3SPYRSPm
reactant: MODEL1310110012#
product: MODEL1310110012#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110012#
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
is described by: ECO:0000000
reversible: false

metaR NACHEX23ly
is: SBO:0000176
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000000
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
kinetic law: MODEL1310110012#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
type: Reaction

metaR G5SADrm
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
product: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
is described by: ECO:0000000
reversible: true
is: SBO:0000176
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_502a1faf_bf5c_4486_8705_fdbc776a03d4
is encoded by: hsa:X63359
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: _X63359_1_c

metaR FAOXC246226x
is described by: ECO:0000000
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110012#
fast: false
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:6 -> c22:6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction

metaM limnen e
type: Species
name: limonene
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H16 CHARGE: 0 INCHI: InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4,10H,1,5-7H2,2-3H3
is: CHEBI:15384
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: HMDB03375

metaR FTHFL
product: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000176
kinetic law: MODEL1310110012#
name: Formate-tetrahydrofolate ligase
is version of: http://identifiers.org/ec-code/1.5.1.5
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110012#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000134

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaR LSTO1r
fast: false
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
modifier: MODEL1310110012#
name: Lathosterol oxidase
reversible: false
kinetic law: MODEL1310110012#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.21.6
product: MODEL1310110012#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110012#_261873fc_f188_43c9_a544_f8613112131c
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:10991
is: SBO:0000252
is: Q99624
initial amount: NaN
constant: false
name: SLC38A3

metaR r0617
product: MODEL1310110012#
reversible: true
type: Reaction
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
is: SBO:0000176
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
fast: false
is described by: ECO:0000000
reactant: MODEL1310110012#

metaR r2352
kinetic law: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110012#
is: SBO:0000185
fast: false
reactant: MODEL1310110012#

metaR FAS120COA
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
product: MODEL1310110012#
name: fatty-acyl-CoA synthase (n-C12:0CoA)
type: Reaction
reversible: false
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000176

metaR r1567
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_76f7fcd2_0b47_4a9d_ad73_464e56a75d0f
has only substance units: false
initial concentration: NaN
is encoded by: hsa:84890
constant: false
boundary condition: true
initial amount: NaN
is: B3KXN9
name: ADO
type: Species
is: SBO:0000252

metaR 5HLTDL
type: Reaction
kinetic law: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:1540578 NOTES:SAB
fast: false
name: 5-Hydroxy-L-tryptophan decarboxy-lyase
reversible: false
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/4.1.1.28
is described by: ECO:0000269
reactant: MODEL1310110012#

metaM CE1926 e
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: gama-carboxyethyl-hydroxychroman
is: CHEBI:15748
initial amount: NaN
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
is: SBO:0000247
type: Species
is: HMDB00127

metaR AG13T17g
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110012#
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110012#

metaR VALTA
reversible: true
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
product: MODEL1310110012#
is described by: ECO:0000269
modifier: MODEL1310110012#
name: valine transaminase
is: SBO:0000176
fast: false
kinetic law: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.42

metaM akg c
initial concentration: 1.0
is: C00026
is: HMDB00208
type: Species
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
name: 2-Oxoglutarate
has only substance units: false
boundary condition: false
is: CHEBI:16810
constant: false
initial amount: NaN
is: SBO:0000247

metaR TMDPPK
name: thiamine-diphosphate kinase
product: MODEL1310110012#
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 2.7.6.2 Confidence Level: 2 AUTHORS: PMID:8522961 NOTES:also EC 2.7.6.2 - NCD
kinetic law: MODEL1310110012#
type: Reaction

metaM gudac c
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C3H7N3O2 CHARGE: 0 INCHI: InChI=1S/C3H7N3O2/c4-3(5)6-1-2(7)8/h1H2,(H,7,8)(H4,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00439 EHMN_ABBREVIATION: C00581
is: HMDB00128
is: CHEBI:16344
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
name: guanidinoacetic acid

metaM 5thf e
type: Species
name: pentaglutamyl folate (THF)
initial concentration: 1.0
is: HMDB06487
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C39H45N11O18 CHARGE: -6
is: SBO:0000247

metaM dec24dicoa m
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB01168
type: Species
is: SBO:0000247
name: 2,4-decadienoylcoa
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
constant: false

metaM oagd3 hs e
initial amount: NaN
is: CHEBI:18421
boundary condition: false
is: HMDB02168
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
initial concentration: 1.0
name: 9-O-Acetylated GD3
has only substance units: false
type: Species
constant: false
is: SBO:0000247

metaM dmhptcrn e
boundary condition: false
constant: false
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB06320
name: 2,6 dimethylheptanoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110012#_9bf30549_32b1_4794_bec9_ef17373180ee
is encoded by: hsa:83715
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is: B1AK53
has only substance units: false
boundary condition: true
name: ESPN
is: SBO:0000252

metaR r1568
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110012#
reversible: true

metaR r0616
type: Reaction
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reversible: true
modifier: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000176
fast: false
is described by: ECO:0000000

metaR RE1530C
product: MODEL1310110012#
reversible: true
name: RE1530
is: SBO:0000176
reactant: MODEL1310110012#
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:

metaM limnen c
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H16 CHARGE: 0 INCHI: InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4,10H,1,5-7H2,2-3H3
boundary condition: false
is: CHEBI:15384
initial amount: NaN
constant: false
is: HMDB03375
name: limonene

metaM ksi pre22 g
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
has only substance units: false
is: HMDB00175
initial concentration: 1.0
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 22
boundary condition: false
type: Species
constant: false
is: C00130

metaR HKYNH
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000269
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8942.1) SUBSYSTEM: Tryptophan metabolism EC Number: 3.7.1.3 Confidence Level: 4 AUTHORS: PMID:9180257 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.7.1.3
reversible: false
name: 3-Hydroxy-L-kynurenine hydrolase
modifier: MODEL1310110012#
product: MODEL1310110012#

metaM glc D r
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00122
constant: false
name: D-glucose
initial concentration: 1.0
is: CHEBI:4167
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_8d3171b6_d7f6_4b08_9314_66e38e7f3d44
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaR EHGLATm
reversible: false
product: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
kinetic law: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000212
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_abd82c07_20b2_438f_9cd5_2fca0f024da1
initial concentration: NaN
is encoded by: hsa:8818
initial amount: NaN
boundary condition: true
name: DPM2
is: SBO:0000252
constant: false
is: O94777
type: Species
has only substance units: false

metaR r1565
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110012#
fast: false
type: Reaction

metaR r2354
type: Reaction
reversible: true
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
fast: false
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110012#
is: SBO:0000185
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_a9105a96_2d99_47fd_9fc4_6a3582d343d2
is: SBO:0000252
is encoded by: hsa:55967
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
name: NDUFA12
constant: false
initial amount: NaN
is: F8VQS7

http://identifiers.org/biomodels.db/MODEL1310110012#_8a5399f7_9022_4fe8_8791_fe2727851100
has only substance units: false
initial concentration: NaN
name: SLC25A20
initial amount: NaN
is: O43772
is encoded by: hsa:788
type: Species
boundary condition: true
constant: false
is: SBO:0000252

metaR r0615
is described by: ECO:0000000
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
modifier: MODEL1310110012#
product: MODEL1310110012#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.168
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
is: SBO:0000176

metaM orot c
is: SBO:0000247
is: C00295
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
constant: false
is: CHEBI:30839
type: Species
name: Orotate
initial amount: NaN
is: HMDB00226
boundary condition: false

metaR FACOAL2042
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110012#
product: MODEL1310110012#
modifier: MODEL1310110012#
reactant: MODEL1310110012#
name: fatty-acid--CoA ligase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_e9a55cbc_cb62_4a28_9905_4bfac25c8f5d
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:6817
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
name: SULT1A1

http://identifiers.org/biomodels.db/MODEL1310110012#_c1a5a1ac_33a1_4605_a0eb_f2850e032faa
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
name: SYNJ1
is: O43426
is encoded by: hsa:8867

http://identifiers.org/biomodels.db/MODEL1310110012#_97e151c9_1de5_4dab_a09c_c4001ce2a487
is: SBO:0000252
boundary condition: true
is encoded by: hsa:137964
constant: false
is: Q86UL3
initial concentration: NaN
type: Species
initial amount: NaN
name: AGPAT6
has only substance units: false

metaR DCYTt
is described by: ECO:0000000
product: MODEL1310110012#
is: SBO:0000185
name: deoxycytidine transport via diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
fast: false
kinetic law: MODEL1310110012#
reversible: true
reactant: MODEL1310110012#

metaR FAOXC121x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_9c742f2e_d5c6_4cbf_b1ed_eaf16d5066b4
initial amount: NaN
has only substance units: false
is: Q8NCL4
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:11226
type: Species
constant: false
boundary condition: true
name: GALNT6

metaR r1566
product: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
is: SBO:0000185
kinetic law: MODEL1310110012#
type: Reaction
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r2353
reactant: MODEL1310110012#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110012#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110012#
type: Reaction
is: SBO:0000185

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaM oagd3 hs g
has only substance units: false
initial amount: NaN
is: CHEBI:58367
is: C00029
is: HMDB00286
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
type: Species
initial concentration: 1.0
name: 9-O-Acetylated GD3

metaR GTHDH
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
name: Glutathione dehydrogenase (dehydroascorbate reductase)
kinetic law: MODEL1310110012#
fast: false
product: MODEL1310110012#
is described by: ECO:0000134
type: Reaction
reversible: false
is: SBO:0000176
reactant: MODEL1310110012#

metaM dmhptcrn c
is: HMDB06320
boundary condition: false
is: SBO:0000247
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
name: 2,6 dimethylheptanoyl carnitine
initial amount: NaN

metaM glyc3p c
name: Glycerol 3-phosphate
type: Species
is: HMDB00126
has only substance units: false
is: CHEBI:57597
initial concentration: 1.0
boundary condition: false
is: C00093
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093

metaR r0614
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
product: MODEL1310110012#
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
fast: false
is: SBO:0000176

metaR r0047
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.4.16
product: MODEL1310110012#
name: Adenosine 5-monophosphate phosphohydrolase Purine metabolism EC:3.1.3.5
reactant: MODEL1310110012#
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: false
notes: GENE_ASSOCIATION: (1373.1) SUBSYSTEM: Purine catabolism EC Number: 3.1.3.5 Confidence Level: 0 AUTHORS: PMID:1550832 NOTES:

metaR r1563
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110012#
is described by: ECO:0000000
reactant: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
is: SBO:0000185
fast: false

metaR C10CRNe
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decanoyl carnitine into extra cellular space
type: Reaction

metaR 34DHOXPEGt
name: 3,4-Dihydroxyphenylethyleneglycol transport (diffusion)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:7473774 NOTES:SAB
reactant: MODEL1310110012#
product: MODEL1310110012#
fast: false
type: Reaction
kinetic law: MODEL1310110012#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110012#_2ab3d8fe_06d2_4156_bcb7_249e9f227f2e
is: SBO:0000252
is: D6RDW3
name: GUCY1A3
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:2982
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR TYRCBOX
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.28
modifier: MODEL1310110012#
reversible: false
reactant: MODEL1310110012#
type: Reaction
name: L-Tyrosine carboxy-lyase

metaR MTHFD2
name: methylenetetrahydrofolate dehydrogenase (NAD)
is version of: http://identifiers.org/ec-code/3.5.4.9
type: Reaction
reactant: MODEL1310110012#
product: MODEL1310110012#
reversible: true
modifier: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
is: SBO:0000176

metaM 2dp6mobq me m
name: 2-decaprenyl-6-methoxy-3-methyl-1,4-benzoquinone
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:50772
notes: FORMULA: C58H88O3 CHARGE: 0 INCHI: InChI=1S/C58H88O3/c1-44(2)23-14-24-45(3)25-15-26-46(4)27-16-28-47(5)29-17-30-48(6)31-18-32-49(7)33-19-34-50(8)35-20-36-51(9)37-21-38-52(10)39-22-40-53(11)41-42-55-54(12)56(59)43-57(61-13)58(55)60/h23,25,27,29,31,33,35,37,39,41,43H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+,53-41+
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_608214ac_8258_412f_bdfa_00443576a7ba
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is: B7Z6Q4
boundary condition: true
name: IMPA1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3612

http://identifiers.org/biomodels.db/MODEL1310110012#_252d386b_182a_49d5_b6a5_f0356e7f0344
constant: false
type: Species
boundary condition: true
has only substance units: false
has part: Q8NCI4
is encoded by: hsa:54872
name: PIGF:PIGG
is: SBO:0000297
initial amount: NaN
initial concentration: NaN

metaR G14T10g
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110012#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110012#

metaM ksi deg21 l
is: SBO:0000247
has only substance units: false
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
name: keratan sulfate I, degradation product 21
is: HMDB00143
is: CHEBI:12936
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_d3ed63aa_ed37_4f0a_86e5_f3debf7310ee
is encoded by: hsa:594
is encoded by: hsa:593
is encoded by: hsa:1629
initial amount: NaN
has part: B4DP47
is: SBO:0000297
name: DBT:DLD:BCKDHA:BCKDHB
constant: false
boundary condition: true
type: Species
has part: P11182
has part: P21953
has only substance units: false
initial concentration: NaN

metaR ABO7g
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.4.1.37
modifier: MODEL1310110012#
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_bfc2edbe_abc3_42bc_b225_975601babfeb
initial concentration: NaN
name: _AV727634_1_c
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AV727634
has only substance units: false

metaM eicostet c
notes: FORMULA: C20H31O2 CHARGE: -1
is: HMDB02177
is: CHEBI:36033
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
name: eicosatetranoic acid
initial amount: NaN

metaR SCP21cx
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of phytanoylcoa from cytosol to peroxisomes.
type: Reaction

metaR TYROXDAc
modifier: MODEL1310110012#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
product: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
type: Reaction
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
is version of: http://identifiers.org/ec-code/1.4.3.4
reactant: MODEL1310110012#

metaR r2356
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110012#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#

metaM k e
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: HMDB00586
initial amount: NaN
is: C00238
constant: false
boundary condition: false
name: potassium
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:29103
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_0dc43325_cf01_4e41_88af_7e281b40cd7a
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is: O75414
is encoded by: hsa:10201
initial concentration: NaN
name: NME6
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_f237a2d2_f4a1_4af5_8dae_a8e5e61d3711
initial amount: NaN
is: P30837
is encoded by: hsa:219
boundary condition: true
constant: false
has only substance units: false
name: ALDH1B1
initial concentration: NaN
type: Species
is: SBO:0000252

metaR r1564
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110012#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110012#
is: SBO:0000185
fast: false
product: MODEL1310110012#
is described by: ECO:0000000
type: Reaction

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_8f1106ab_3c22_4d38_a381_d60358d6aefb
is encoded by: hsa:389015
boundary condition: true
is: Q6AI14
is: SBO:0000252
constant: false
initial amount: NaN
name: SLC9A4
has only substance units: false
initial concentration: NaN
type: Species

metaM thmmp c
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
is: CHEBI:37575
name: Thiamin monophosphate
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: C01081
has only substance units: false
constant: false
is: HMDB02666
type: Species

metaR S4TASE2ly
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
product: MODEL1310110012#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
reversible: true
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.1.6.12

metaM maltpt e
name: maltopentaose
type: Species
is: http://identifiers.org/pubchem.compound/5141
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
is: C02052
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB01296
constant: false

metaR S2TASE2ly
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.1.6.13
type: Reaction
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
reversible: false
reactant: MODEL1310110012#
modifier: MODEL1310110012#
name: iduronate-2-sulfatase, lysosomal
kinetic law: MODEL1310110012#

metaM thyox L c
boundary condition: false
name: L-thyroxine
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18332
is: SBO:0000247
constant: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: HMDB00248
type: Species
has only substance units: false

metaR r2355
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110012#
name: Organic anion transporter 5 Utilized transport
fast: false
kinetic law: MODEL1310110012#
is: SBO:0000185
reversible: true
reactant: MODEL1310110012#

metaR r1561
is: SBO:0000185
product: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110012#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_807e5670_7b67_4fab_b193_eb02036ee469
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q13907
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
name: IDI1
is encoded by: hsa:3422

metaR r2358
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
product: MODEL1310110012#
fast: false
type: Reaction
kinetic law: MODEL1310110012#
name: Organic anion transporter 5 Utilized transport

metaM ivcoa c
has only substance units: false
name: Isovaleryl-CoA
is: HMDB01113
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_cdee393c_24ff_48e5_897f_e5d026995cc6
is: SBO:0000252
has only substance units: false
constant: false
type: Species
name: _AA021081_1_r
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AA021081
initial amount: NaN

metaM hxcoa c
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB13130
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
name: Hexanoyl-CoA (n-C6:0CoA)
initial concentration: 1.0

metaR r0611
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251 NOTES:
type: Reaction
modifier: MODEL1310110012#
reactant: MODEL1310110012#
product: MODEL1310110012#
reversible: true
kinetic law: MODEL1310110012#
name: ITP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
is version of: http://identifiers.org/ec-code/1.2.3.1

metaR PETHCT
is: SBO:0000176
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (5833.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.14 Confidence Level: 4 AUTHORS: NOTES:NCD
modifier: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.14
name: phosphoethanolamine cytidyltransferase

http://identifiers.org/biomodels.db/MODEL1310110012#_63400131_79b9_44a6_b177_e84d379560e7
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:LOC727762
type: Species
constant: false
name: _LOC727762_1_m
initial concentration: NaN

metaM eicostet e
is: CHEBI:36033
is: SBO:0000247
notes: FORMULA: C20H31O2 CHARGE: -1
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: HMDB02177
name: eicosatetranoic acid

metaR B3GNT32g
modifier: MODEL1310110012#
reversible: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110012#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110012#_7fd03dc8_b8a6_48d2_b0c6_4adf9e4e1276
is encoded by: hsa:5152
constant: false
initial concentration: NaN
name: PDE9A
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN

metaR MAOX
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.4.3.21
name: Methylamine oxidase
modifier: MODEL1310110012#
is: SBO:0000176
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.4.3.22
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:11136547,PMID:14715500,PMID:9131641 NOTES:SAB
fast: false
reversible: false
kinetic law: MODEL1310110012#
type: Reaction
is described by: ECO:0000304

metaM doco13ac e
has only substance units: false
is: HMDB02068
notes: FORMULA: C22H41O2 CHARGE: -1
boundary condition: false
initial concentration: 1.0
constant: false
name: docosenoic acid (C22:1)
is: SBO:0000247
type: Species
initial amount: NaN

metaR GLCAASE1ly
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.31
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
name: beta-glucuronidase, lysosomal
modifier: MODEL1310110012#
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110012#

metaM k c
is: HMDB00586
initial amount: NaN
boundary condition: false
name: potassium
is: C00238
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:29103
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: SBO:0000247

metaR r1562
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110012#
product: MODEL1310110012#
fast: false
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110012#_223e8ebc_8382_4d61_9a18_9effc94237ae
is: H7C5B8
initial amount: NaN
constant: false
boundary condition: true
name: NDUFB2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4708
is: SBO:0000252
type: Species

metaM 3hexdtetcoa m
initial concentration: 1.0
initial amount: NaN
name: 3,7,10,13-hexadecatetraenoylcoa
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: HMDB02288
type: Species
is: SBO:0000247

metaR TSULt4 3
product: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
reversible: true
modifier: MODEL1310110012#
name: thiosulfate transport via sodium symport
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
type: Reaction

metaM gchola c
name: glycocholate
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
constant: false
is: HMDB00138
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:58235
is: SBO:0000247
initial amount: NaN

metaR BTNt4i
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
reversible: false
modifier: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
name: Biotin uptake (antiport)
kinetic law: MODEL1310110012#
is described by: ECO:0000269
is: SBO:0000185
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_2d7d4a8b_ac08_4502_b4eb_9f08696a63af
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaM thmmp e
is: CHEBI:37575
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: thiamine(1+) monophosphate(2-)
notes: FORMULA: C12H16N4O4PS CHARGE: -1 INCHI: InChI=1S/C12H17N4O4PS/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19)/p-1 EHMN_ABBREVIATION: C01081
constant: false
is: HMDB02666
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_64348d78_4199_4e04_bb4f_ac90496aac75
name: ACAA1
is: Q96CA6
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:30
constant: false

metaR r0610
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251,PMID:193556,PMID:2987258,PMID:6091737 NOTES:
type: Reaction
reversible: true
fast: false
name: CTP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
reactant: MODEL1310110012#
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000176

metaR r2357
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110012#
fast: false
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
reversible: true

metaR r1847
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110012#
fast: false
type: Reaction
reactant: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
modifier: MODEL1310110012#
is described by: ECO:0000000

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

metaM thyox L e
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:18332
is: SBO:0000247
name: L-thyroxine
initial concentration: 1.0
constant: false
is: HMDB00248
type: Species
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849

metaR C6DCCACT
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of adipoyl carnitine into cytosol
type: Reaction

metaR GLCNACASE1ly
is: SBO:0000176
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
name: alpha-N-acetylglucosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.50
reactant: MODEL1310110012#
modifier: MODEL1310110012#
reversible: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110012#
product: MODEL1310110012#
fast: false

metaR GLYCtm
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: glycerol transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
reactant: MODEL1310110012#
reversible: true
type: Reaction

metaR MI1345PP
is version of: http://identifiers.org/ec-code/3.1.3.56
kinetic law: MODEL1310110012#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.36
is: SBO:0000176
reversible: false
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.1.3.86
is described by: ECO:0000269
product: MODEL1310110012#
reactant: MODEL1310110012#
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD

metaR LEUt5m
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110012#
type: Reaction
name: leucine mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
fast: false
product: MODEL1310110012#
kinetic law: MODEL1310110012#

metaR CREATt4 2 r
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000269
modifier: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000185
name: Creatine transport (sodium symport) (2:1)
fast: false
type: Reaction
reactant: MODEL1310110012#
reversible: true

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaM m7masnC g
is: HMDB06814
is: CHEBI:58401
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform C (protein)
type: Species
initial amount: NaN
notes: FORMULA: C64H107N2O50X CHARGE: 0
boundary condition: false

metaR FACOAL240
type: Reaction
product: MODEL1310110012#
name: fatty-acid--CoA ligase
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110012#
modifier: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_2a6baf37_5683_44e1_9698_c0dc17466188
constant: false
name: _AI601100_1_m
initial concentration: NaN
is encoded by: hsa:AI601100
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM etoh e
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:16236
name: ethanol
is: HMDB00108

metaR r0946
reactant: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: true
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110012#
is described by: ECO:0000000

metaM 3ivcoa m
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: C05998
is: http://identifiers.org/pubchem.compound/11966188
is: SBO:0000247
constant: false
name: 3-hydroxyisovalerylcoa
boundary condition: false
is: HMDB06870
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_02488c88_3b54_4c86_b3b3_6cb3bcbf94e1
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: Q6IBE6
type: Species
initial amount: NaN
is encoded by: hsa:6484
name: ST3GAL4
is: SBO:0000252

metaR ACGPID
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.89
is: SBO:0000176
product: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
name: N-acetylglucosaminylphosphatidylinositol deacetylase
reversible: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110012#_75e0306c_3864_4e2a_8b58_1836ac09a698
constant: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: P34059
has only substance units: false
is: SBO:0000252
name: GALNS
is encoded by: hsa:2588

metaM glu L m
is: SBO:0000247
name: L-glutamate(1-)
type: Species
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial amount: NaN
is: CHEBI:29985
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: HMDB00148

metaR r2359
reactant: MODEL1310110012#
is described by: ECO:0000000
reversible: true
name: Organic anion transporter 5 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110012#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110012#

metaM inost e
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: CHEBI:17268
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00211
is: SBO:0000247
name: myo-inositol

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

metaR r1560
product: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000

metaM dcholcoa x
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:28701
boundary condition: false
name: chenodeoxycholoyl coenzyme a
constant: false
type: Species
is: HMDB06292
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337

metaM pnto R c
boundary condition: false
type: Species
name: (R)-Pantothenate
initial amount: NaN
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
has only substance units: false
is: CHEBI:7916
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00210

http://identifiers.org/biomodels.db/MODEL1310110012#_ce9b084c_9bf9_4f86_8ecb_4d890cfc8c83
is encoded by: hsa:4329
is: Q02252
boundary condition: true
constant: false
name: ALDH6A1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species

metaM ksi deg14 l
type: Species
is: HMDB00143
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:12936
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 14

metaR FAOXC204184m
reactant: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 rounds of beta ox c20:4 -> c18:4 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110012#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110012#
name: Beta oxidation fatty acid
is: SBO:0000176
kinetic law: MODEL1310110012#

metaM dhdascb c
is: CHEBI:58070
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: HMDB01264
initial concentration: 1.0
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
boundary condition: false
name: dehydroascorbide(1-)
constant: false

metaR r1842
reversible: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110012#
modifier: MODEL1310110012#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110012#_61ba5bec_d933_49b2_abaf_0a9e4576c5ab
is encoded by: hsa:4905
is: SBO:0000297
has part: P05496
is encoded by: hsa:9551
is encoded by: hsa:521
is encoded by: hsa:515
has only substance units: false
initial concentration: NaN
has part: O75964
boundary condition: true
has part: A0PJH2
constant: false
initial amount: NaN
is encoded by: hsa:10476
type: Species
name: ATP5H:ATP5L:NSF:ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
has part: P46459
has part: Q6IBB3
has part: P56385
has part: Q08ET0
is encoded by: hsa:522
is encoded by: hsa:516
is encoded by: hsa:10632

metaR NADH2 u10m
name: NADH dehydrogenase, mitochondrial
product: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
type: Reaction
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
reactant: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.6.99.3
is version of: http://identifiers.org/ec-code/1.6.5.3
reversible: false

metaR C14OHc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecanoylcarnitine
type: Reaction

metaR S6TASE1ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true
product: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD

metaR RE3567C
fast: false
name: RE3567
product: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is: SBO:0000176
reversible: true
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000000

metaM succ x
initial amount: NaN
initial concentration: 1.0
constant: false
is: C00042
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:30031
is: HMDB00254
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
name: Succinate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_3b4495cb_4038_4e26_8630_428f8abd8e48
is encoded by: hsa:4967
name: OGDH
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is: Q02218
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_c5f9857f_32f9_413a_b99c_07215fc1f1f6
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
name: _728226_1_e
type: Species
is encoded by: hsa:728226
initial concentration: NaN
is: SBO:0000252

metaM xol27oh m
has only substance units: false
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: HMDB02103
is: CHEBI:17703
boundary condition: false
initial amount: NaN
name: 26-hydroxycholesterol
initial concentration: 1.0

metaR TAURt4 2 r
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110012#
is: SBO:0000185
reactant: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
reversible: true
type: Reaction
name: taurine transport (sodium symport) (2:1)
is described by: ECO:0000269
modifier: MODEL1310110012#

metaM HC02023 r
has only substance units: false
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
name: Cholesterol-ester-ol
initial concentration: 1.0
type: Species
is: CHEBI:46898
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaM 3hexdtetcoa x
has only substance units: false
is: HMDB02288
name: 3,7,10,13-hexadecatetraenoylcoa
boundary condition: false
constant: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR SGALSIDEtg
reactant: MODEL1310110012#
is: SBO:0000185
name: sgalside hs intracellular transport
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
type: Reaction
kinetic law: MODEL1310110012#
product: MODEL1310110012#
fast: false

metaR S6T15g
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
modifier: MODEL1310110012#
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.8.2.21
product: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.8.2.17
type: Reaction
fast: false
kinetic law: MODEL1310110012#

metaM dlnlcgcoa c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
name: dihomo-gamma-linolenyl coenzyme A
boundary condition: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
is: CHEBI:27979
initial amount: NaN

metaM xoldiolone c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28477
type: Species
boundary condition: false
constant: false
initial amount: NaN
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
is: HMDB02197
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
has only substance units: false

metaM etoh c
is: HMDB00108
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: ethanol
type: Species
is: CHEBI:16236

metaR EX phyt LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phytanic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_cc0b14d9_011c_49de_8e75_c9d382774b3a
initial amount: NaN
boundary condition: true
constant: false
name: PIGQ
is encoded by: hsa:9091
initial concentration: NaN
type: Species
is: Q9BRB3
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_c11c69f2_cec8_467c_aafd_1d7f794e21c3
initial concentration: NaN
is: E9PAY8
type: Species
has only substance units: false
is encoded by: hsa:8612
constant: false
initial amount: NaN
name: PPAP2C
is: SBO:0000252
boundary condition: true

metaR PTE4x
fast: false
type: Reaction
reactant: MODEL1310110012#
is: SBO:0000176
product: MODEL1310110012#
modifier: MODEL1310110012#
reversible: false
name: peroxisomal acyl-CoA thioesterase
is version of: http://identifiers.org/ec-code/3.1.2.2
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
kinetic law: MODEL1310110012#
is described by: ECO:0000269

metaR FAOXC225C226m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

metaM C05279 m
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:28387
initial concentration: 1.0
name: trans,cis-Lauro-2,6-dienoyl-CoA
initial amount: NaN
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
type: Species
is: HMDB11123

http://identifiers.org/biomodels.db/MODEL1310110012#_ea6c362a_9376_4bd1_8b6d_bcd56794828d
initial concentration: NaN
type: Species
is encoded by: hsa:6487
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
name: ST3GAL3

metaR THRGLYexR
is: SBO:0000185
modifier: MODEL1310110012#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
name: L-threonine/glycine reversible exchange
reversible: true
product: MODEL1310110012#

metaR FACOAL241
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
name: fatty-acid--CoA ligase
reversible: true
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
is: SBO:0000176
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_f066eb4e_b8fd_4b2b_894a_779d8982fea7
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
name: ALG8
constant: false
is encoded by: hsa:79053

metaR S6T6g
type: Reaction
reversible: false
is: SBO:0000176
reactant: MODEL1310110012#
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
fast: false
product: MODEL1310110012#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110012#_54756ca1_b196_4377_b131_689b5a5f3eb0
initial amount: NaN
is: O00217
name: NDUFS8
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:4728
has only substance units: false
is: SBO:0000252

metaR ACNMLr
kinetic law: MODEL1310110012#
name: N-Acetylneuraminate lyase (reversible)
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 4.1.3.3 Confidence Level: 2 AUTHORS: NOTES:JLR
fast: false
reversible: true
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110012#
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_8b5833b1_b503_4daa_b0ea_7374c976787e
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5281
is: Q07326
name: PIGF

metaR GLCNACASE4ly
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
fast: false
name: alpha-N-acetylglucosaminidase, lysosomal
reversible: false
reactant: MODEL1310110012#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.50
is: SBO:0000176
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_71855670_d85d_4534_8d8d_552af290acd8
initial concentration: NaN
name: BDH1
is encoded by: hsa:622
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false

metaM pnto R e
is: CHEBI:7916
name: (R)-Pantothenate
boundary condition: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00210
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_47c0b90e_d587_424e_8fb2_06ea800ab0d0
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
name: ATP1A2
is: P50993
boundary condition: true
type: Species
is encoded by: hsa:477

metaR ICDHyrm
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
is described by: ECO:0000269
reversible: true
name: Isocitrate dehydrogenase (NADP+)
kinetic law: MODEL1310110012#
fast: false
type: Reaction
product: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.42

metaM ha pre1 l
type: Species
is: CHEBI:16126
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: hyaluronan biosynthesis, precursor 1
has only substance units: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1

metaR ACHEe
is: SBO:0000176
product: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
modifier: MODEL1310110012#
name: Acetylcholinesterase
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.7
reversible: false

metaR r0002
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
name: Active transport
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
reversible: true

metaM g3m8mpdol U r
has only substance units: false
is: C05873
notes: FORMULA: C1905H3140N20O770P20 CHARGE: -20
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247

metaR FAOXC181C161m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C16:1)m
type: Reaction

metaR RE0827E
modifier: MODEL1310110012#
reversible: false
type: Reaction
kinetic law: MODEL1310110012#
is described by: ECO:0000000
reactant: MODEL1310110012#
is: SBO:0000176
fast: false
name: RE0827
is version of: http://identifiers.org/ec-code/1.4.3.22
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:

metaR S6T17g
product: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000176
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaR r2511
reactant: MODEL1310110012#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110012#
is described by: ECO:0000000
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110012#_c5f624c3_82b1_4d4a_b281_bd42d5b8dbbf
type: Species
has only substance units: false
name: COQ6
is: SBO:0000252
is: B7Z3K8
is encoded by: hsa:51004
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN

metaM clpndcoa c
boundary condition: false
constant: false
type: Species
has only substance units: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
name: clupanodonyl CoA
is: http://identifiers.org/pubchem.compound/47205476
initial concentration: 1.0
is: HMDB06267
is: SBO:0000247
initial amount: NaN
is: C16166

metaR FAOXC185m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

metaM xol27oh r
constant: false
type: Species
is: HMDB02103
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17703
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
boundary condition: false
has only substance units: false
initial amount: NaN
name: 26-hydroxycholesterol

metaM tettet6 c
is: HMDB06246
name: tetracosatetraenoic acid n-6
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
boundary condition: false
initial concentration: 1.0
constant: false

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_b8ab7722_af19_4e54_b9c1_2b9f16ace80e
is: P07864
type: Species
name: LDHC
is encoded by: hsa:3948
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM nm2masn g
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
type: Species
initial concentration: 1.0
is: C05884
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C42H70N3O30X CHARGE: 0
constant: false

metaM ddsmsterol r
boundary condition: false
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
is: CHEBI:27910
is: HMDB03896
initial amount: NaN
name: 7-dehydrodesmosterol
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_933d9ea5_8c52_43c0_94a0_f688af25d4e4
initial amount: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
has part: Q13733
is encoded by: hsa:480
initial concentration: NaN
name: ATP1A4:ATP1B1
is: SBO:0000297

metaM 2octdectecoa m
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280355
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: 2,6,9,12-octadecatetraenoylcoa
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_d813ae28_548a_474b_ae97_e3021b49da6c
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2678
name: GGT1
boundary condition: true
constant: false
type: Species
is: P19440
initial amount: NaN

metaR FAOXC226C227m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

metaR DHEAtr
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000269
product: MODEL1310110012#
fast: false
name: Dehydroepiandrosterone transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.8.2.2 Confidence Level: 1 AUTHORS: PMID:11535246,PMID:1588921 NOTES:
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#

metaR THFtm
type: Reaction
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
product: MODEL1310110012#
reversible: true
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110012#
fast: false
is described by: ECO:0000000

metaM methf c
type: Species
is: C00445
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: CHEBI:57455
has only substance units: false
is: HMDB01354
name: 5,10-Methenyltetrahydrofolate

metaM tettet6 e
constant: false
type: Species
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
boundary condition: false
initial concentration: 1.0
name: tetracosatetraenoic acid n-6
initial amount: NaN
is: HMDB06246
is: SBO:0000247
has only substance units: false

metaM dha e
is: SBO:0000247
is: CHEBI:16016
name: glycerone
has only substance units: false
is: HMDB01882
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_5506a97e_0b8a_4e7d_933f_bb16a6b6d144
initial concentration: NaN
constant: false
is: P56181
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:4731
name: NDUFV3
has only substance units: false
type: Species

metaM dcholcoa r
is: CHEBI:28701
boundary condition: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
type: Species
initial concentration: 1.0
is: HMDB06292
constant: false
name: chenodeoxycholoyl coenzyme a
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM thym c
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
name: Thymine
initial concentration: 1.0
is: CHEBI:17821
is: C00178
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00262
type: Species

metaM lneldccoa m
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB01064
constant: false
name: linoelaidyl coenzyme A
is: http://identifiers.org/pubchem.compound/5462164
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_ce26b416_627b_4c1f_beeb_c0a149c662cd
is encoded by: hsa:64064
name: OXCT2
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: Q9BYC2
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM 3mldz c
initial amount: NaN
has only substance units: false
type: Species
is: HMDB04181
name: 1-methylimidazole-4-acetaldehyde
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C6H8N2O CHARGE: 0 INCHI: InChI=1S/C6H8N2O/c1-8-4-6(2-3-9)7-5-8/h3-5H,2H2,1H3 EHMN_ABBREVIATION: C05827
is: CHEBI:28104

metaM inost c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
type: Species
is: CHEBI:17268
is: SBO:0000247
name: myo-inositol
constant: false
initial amount: NaN
boundary condition: false
is: HMDB00211

http://identifiers.org/biomodels.db/MODEL1310110012#_1b4e90fb_420f_4df7_9c03_4429facf30bc
is: SBO:0000252
is: B7Z2T0
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:478
name: ATP1A3
constant: false

metaR RE2659R
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
kinetic law: MODEL1310110012#
is: SBO:0000176
product: MODEL1310110012#
name: RE2659
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110012#
type: Reaction

metaR GLYt2r
fast: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
is: SBO:0000185
is described by: ECO:0000304
reversible: true
modifier: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
name: glycine reversible transport via proton symport

http://identifiers.org/biomodels.db/MODEL1310110012#_4988ee9b_a2b8_4d01_9b52_739276f345d9
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:2752
is: P15104
name: GLUL

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaM retinol 9 cis c
is: CHEBI:17336
initial amount: NaN
type: Species
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB06217
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
name: 9-cis-retinol

metaM apoC Lys m
type: Species
boundary condition: false
is: HMDB00182
is: CHEBI:32551
constant: false
notes: FORMULA: C6H13N2OX CHARGE: 0
name: Apocarboxylase (Lys residue)
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM 3dhguln c
constant: false
is: HMDB06334
is: CHEBI:57655
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
name: 3-dehydro-L-gulonate

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaR CSEPASEly
type: Reaction
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
reversible: false
product: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#

metaR CHSTEROLtrc
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
is described by: ECO:0000134
kinetic law: MODEL1310110012#
is: SBO:0000185
name: transport of cholesterol into the cytosol
reversible: true
type: Reaction
reactant: MODEL1310110012#
product: MODEL1310110012#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_aae87cf1_1232_4287_83a9_026e4cefb7f2
is encoded by: hsa:3418
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: IDH2
is: P48735
type: Species
boundary condition: true
is: SBO:0000252

metaR sink c101coa LPAREN c RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C101COASINK
type: Reaction

metaR FAOXC225C204m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaM dlnlcgcoa m
has only substance units: false
boundary condition: false
is: CHEBI:27979
is: SBO:0000247
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
name: dihomo-gamma-linolenyl coenzyme A
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_923de47a_7c81_484d_95ab_971041bf8f65
initial amount: NaN
name: PANK2
initial concentration: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:80025

http://identifiers.org/biomodels.db/MODEL1310110012#_c3d814bf_f126_4d94_baf2_fc9c1316f39a
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:9488
constant: false
is: SBO:0000252
initial concentration: NaN
name: PIGB
is: Q92521

metaR r2516
product: MODEL1310110012#
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110012#

metaM gdp e
type: Species
is: SBO:0000247
constant: false
is: HMDB01201
initial concentration: 1.0
name: GDP(3-)
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:58189

http://identifiers.org/biomodels.db/MODEL1310110012#_metaM_fucfucgalacglcgalacglcgal14acglcgalgluside_hs_g
type: Species
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:61648

metaM ivcoa m
is: HMDB01113
name: Isovaleryl-CoA
constant: false
is: CHEBI:57345
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_499a7142_13f7_41b3_80d0_d1b1b2d1fa45
is: O00219
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
boundary condition: true
name: HAS3
is encoded by: hsa:3038
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110012#_12269c82_8164_4c81_8a24_6979df7a565b
initial amount: NaN
type: Species
boundary condition: true
is: Q6FG42
is: SBO:0000252
is encoded by: hsa:4701
constant: false
name: NDUFA7
initial concentration: NaN
has only substance units: false

metaM glc D c
boundary condition: false
constant: false
is: HMDB00122
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
initial amount: NaN
is: CHEBI:4167
initial concentration: 1.0
name: D-glucose
type: Species
is: SBO:0000247

metaR FAOXC181C161x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C18:1-->C16:1)x
type: Reaction

metaR RBK
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
fast: false
is: SBO:0000176
name: ribokinase
reactant: MODEL1310110012#
type: Reaction
modifier: MODEL1310110012#
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.1.15
kinetic law: MODEL1310110012#
is described by: ECO:0000304

metaR UGT1A10r
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
product: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110012#
reversible: true
is version of: http://identifiers.org/ec-code/2.4.1.17
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110012#_186ed90d_912a_4c7c_91e4_a50414c0047e
is encoded by: hsa:374907
name: B3GNT8
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_f00f74ef_059b_4541_98a4_5332bbe389a0
initial concentration: NaN
is encoded by: hsa:223
boundary condition: true
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is: P49189
name: ALDH9A1
initial amount: NaN

metaM nmn c
is: C00455
initial concentration: 1.0
is: SBO:0000247
name: NMN
constant: false
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
is: CHEBI:14649
is: HMDB00229
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_0e9accd3_95f9_4dcf_84bf_504665b689cd
is: P27987
is encoded by: hsa:3707
has only substance units: false
initial amount: NaN
name: ITPKB
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN

metaR APAT2rm
modifier: MODEL1310110012#
reversible: true
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/2.6.1.19
reactant: MODEL1310110012#
is: SBO:0000176
kinetic law: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
type: Reaction
fast: false

metaM 3hddcoa m
is: C05279
boundary condition: false
constant: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
type: Species
is: HMDB11123
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: (S)-3-Hydroxydodecanoyl-CoA

metaM 34hpp e
boundary condition: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
is: SBO:0000247
is: CHEBI:36242
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00707
name: 3-(4-hydroxyphenyl)pyruvate

metaR FAOXC7C5m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C7-->C5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_b1fa2d7d_2231_444d_b9dd_6e965313df01
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:4830
has only substance units: false
name: NME1
boundary condition: true
initial concentration: NaN

metaR S23T4g
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000000
product: MODEL1310110012#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.4
modifier: MODEL1310110012#
name: beta-galactoside alpha-2,3-sialyltransferase
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
fast: false
is: SBO:0000176
reversible: false

metaM dcdp n
is: HMDB01245
type: Species
is: CHEBI:58593
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
boundary condition: false
is: SBO:0000247
name: dCDP(3-)
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR r0321
reversible: false
reactant: MODEL1310110012#
is: SBO:0000176
fast: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
is version of: http://identifiers.org/ec-code/6.3.5.2
product: MODEL1310110012#

metaM xylu D c
type: Species
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m1/s1
is: HMDB01644
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:17140
is: SBO:0000247
name: D-xylulose
constant: false

metaM 3hodcoa m
initial concentration: 1.0
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
name: (S)-3-Hydroxyoctadecanoyl-CoA
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false
constant: false
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR S6TASE3ly
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110012#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
product: MODEL1310110012#
reversible: true
reactant: MODEL1310110012#

metaR RE2814M
type: Reaction
reversible: true
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
reactant: MODEL1310110012#
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: RE2814
kinetic law: MODEL1310110012#

metaR RE1845C
type: Reaction
name: RE1845
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110012#
reactant: MODEL1310110012#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_8a137627_a57d_4996_8aee_f807927629d6
initial concentration: NaN
constant: false
is: SBO:0000252
name: GGT7
is: A0PJJ9
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:2686
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_d3394939_63fb_42b3_aac6_8f4cbf7a9a02
name: ADCY3
type: Species
is: B3KT86
constant: false
is encoded by: hsa:109
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_292ac690_b9b8_4f4c_b44f_7ef6aed03a05
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:83530
constant: false
has only substance units: false
name: _83530_1_c

metaR DNDPt9m
reversible: false
is described by: ECO:0000269
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110012#
name: dADP transport via dTDP antiport
modifier: MODEL1310110012#
reactant: MODEL1310110012#

metaM 3thexddcoacrn e
type: Species
boundary condition: false
notes: FORMULA: C23H41NO5 CHARGE: 0
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB02014
initial amount: NaN

metaR r2514
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
kinetic law: MODEL1310110012#
is described by: ECO:0000000
fast: false
product: MODEL1310110012#
reversible: true
type: Reaction
is: SBO:0000185

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_578f6ceb_e811_4a60_ab16_cd44400f7d9f
is: P23677
type: Species
name: ITPKA
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3706

metaR NDPK10n
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110012#
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
product: MODEL1310110012#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
reversible: true
is described by: ECO:0000304
fast: false
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_b78aaac5_1413_4af8_b8de_3cfc6db18ea2
name: _AA576959_1_c
is encoded by: hsa:AA576959
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false

metaM hdcea r
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:32372
is: HMDB03229
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: palmitoleate
type: Species

metaR ASAH1
modifier: MODEL1310110012#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (427.1) or (427.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.5.1.23 Confidence Level: 4 AUTHORS: PMID:8955159 NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.5.1.23
reversible: false
fast: false
name: N-acylsphingosine amidohydrolase
kinetic law: MODEL1310110012#
product: MODEL1310110012#

metaM 34hpp c
initial amount: NaN
boundary condition: false
is: HMDB00707
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
has only substance units: false
is: CHEBI:36242
is: SBO:0000247
initial concentration: 1.0
constant: false
name: 3-(4-hydroxyphenyl)pyruvate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_1b2a0c91_05b9_4721_a4f4_c34af3f18308
boundary condition: true
is: F8WDN9
is: SBO:0000252
initial concentration: NaN
name: PPA2
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:27068
type: Species

metaM 3snpyr m
is: HMDB02332
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:1665
initial concentration: 1.0
name: 3-Sulfinopyruvate
is: SBO:0000247
type: Species
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_ac4d0690_b724_405e_8777_8b6daa6b9030
initial concentration: NaN
is: P27707
is: SBO:0000252
is encoded by: hsa:1633
type: Species
has only substance units: false
boundary condition: true
name: DCK
constant: false
initial amount: NaN

metaM gdp g
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:58189
initial concentration: 1.0
name: GDP(3-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_78b8a94c_3f1b_480f_9dd1_71a03f55fa23
is: P49327
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2194
name: FASN
constant: false
boundary condition: true
initial concentration: NaN

metaM cortsn r
initial amount: NaN
type: Species
is: SBO:0000247
name: cortisone
is: CHEBI:16962
notes: FORMULA: C21H28O5 CHARGE: 0 INCHI: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00762
constant: false
has only substance units: false
boundary condition: false
is: HMDB02802
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_619df028_813f_44f2_9853_b68c0673e540
has only substance units: false
boundary condition: true
name: ACP5
is: P13686
constant: false
initial amount: NaN
is encoded by: hsa:54
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_3ef11d8b_a365_4a38_8cdb_a1e412846f63
has only substance units: false
is: P47895
initial amount: NaN
is encoded by: hsa:220
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: ALDH1A3
boundary condition: true

metaM ksi deg39 l
boundary condition: false
is: SBO:0000247
notes: FORMULA: C48H81N3O36 CHARGE: 0
is: CHEBI:12936
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
name: keratan sulfate I, degradation product 39
is: HMDB00143
initial amount: NaN

metaM xoldiolone r
is: CHEBI:28477
initial concentration: 1.0
is: HMDB02197
type: Species
constant: false
boundary condition: false
is: SBO:0000247
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
initial amount: NaN
has only substance units: false

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaR r1019
fast: false
kinetic law: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110012#
reversible: true
reactant: MODEL1310110012#
name: Postulated transport reaction

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR ALDD2x
is version of: http://identifiers.org/ec-code/1.2.1.36
is described by: ECO:0000000
name: aldehyde dehydrogenase (acetaldehyde, NAD)
modifier: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5

http://identifiers.org/biomodels.db/MODEL1310110012#_a90d7241_59c2_4f1b_969f_8c270ceb6d32
boundary condition: true
has part: Q7L2M7
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:5211
initial concentration: NaN
type: Species
constant: false
has only substance units: false
name: PFKL:PFKP

http://identifiers.org/biomodels.db/MODEL1310110012#_da91b226_5b43_4727_953e_246b5b57ac9d
is encoded by: hsa:2639
has only substance units: false
name: GCDH
type: Species
is: SBO:0000252
initial amount: NaN
is: Q92947
boundary condition: true
initial concentration: NaN
constant: false

metaM ksi deg22 l
initial amount: NaN
constant: false
notes: FORMULA: C132H214N9O111S5 CHARGE: -5
boundary condition: false
has only substance units: false
is: SBO:0000247
name: keratan sulfate I, degradation product 22
type: Species
is: CHEBI:16953
is: HMDB00812
initial concentration: 1.0

metaM tyr L e
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00158
name: L-tyrosine
has only substance units: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: CHEBI:17895
boundary condition: false
type: Species
initial amount: NaN

metaR RE1517M
reversible: true
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000000
name: RE1517
is version of: http://identifiers.org/ec-code/1.3.99.13
is: SBO:0000176
kinetic law: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:

metaM 4hbz m
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C7H5O3 CHARGE: -1 INCHI: InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)/p-1
initial concentration: 1.0
initial amount: NaN
type: Species
name: 4-hydroxybenzoate
is: HMDB00500
is: CHEBI:17879
constant: false

metaR FUT911g
type: Reaction
product: MODEL1310110012#
is described by: ECO:0000269
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.4.1.152
fast: false
is: SBO:0000176
name: Alpha-(1,3)-fucosyltransferase
kinetic law: MODEL1310110012#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110012#_fe13fcef_336d_4cfb_8979_9b81db40ebf2
type: Species
name: _H17063_1_m
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:H17063
is: SBO:0000252
initial concentration: NaN

metaR SGALSIDEtl
kinetic law: MODEL1310110012#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: sgalside hs intracellular transport
reactant: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ

metaR LTD4DP
product: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
name: Leukotriene D4 dipeptidase
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_36d79723_8f1a_40c0_9d5b_3d68e2c8d0d7
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: Q8NEM3
is encoded by: hsa:9194
constant: false
name: SLC16A7
boundary condition: true
initial amount: NaN

metaM dlnlcgcoa r
initial amount: NaN
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
is: SBO:0000247
is: C03595
has only substance units: false
is: CHEBI:27979
constant: false
type: Species
initial concentration: 1.0
name: dihomo-gamma-linolenyl coenzyme A
boundary condition: false

metaR r1018
is: SBO:0000185
name: Transport reaction
product: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110012#
reversible: true

metaR GMPtg
name: GMP transport (Golgi)
fast: false
product: MODEL1310110012#
reversible: true
type: Reaction
kinetic law: MODEL1310110012#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:

metaR ALDD2y
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
kinetic law: MODEL1310110012#
product: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.36
type: Reaction
is: SBO:0000176
modifier: MODEL1310110012#
name: aldehyde dehydrogenase (acetaldehyde, NADP)

http://identifiers.org/biomodels.db/MODEL1310110012#_af531ac4_3060_4495_bf8a_a69b61adea61
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
name: ACAD8
is encoded by: hsa:27034
initial amount: NaN
is: SBO:0000252
type: Species
is: Q6ZWP6

metaR SQLSr
reactant: MODEL1310110012#
name: Squalene synthase
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.5.1.21
is: SBO:0000176
product: MODEL1310110012#
is described by: ECO:0000134
type: Reaction
fast: false
kinetic law: MODEL1310110012#
reversible: false

metaR MALTSULtm
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
name: Malate:thiosulfate antiport, mitochondrial
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
product: MODEL1310110012#
fast: false

metaR GALASE17ly
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110012#
name: beta-galactosidase, lysosomal
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110012#
is described by: ECO:0000000
kinetic law: MODEL1310110012#
is: SBO:0000176
type: Reaction

metaR r0470
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
product: MODEL1310110012#
reactant: MODEL1310110012#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

http://identifiers.org/biomodels.db/MODEL1310110012#_6f8df731_00bf_4324_9fcb_fdeb7f274f32
is encoded by: hsa:D87002
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
name: _D87002_1_m
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110012#_f4c448d1_138b_4091_b4f0_30df0c2e084e
is encoded by: hsa:AI631997
boundary condition: true
has only substance units: false
name: _AI631997_1_m
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
initial amount: NaN

metaM glyc3p x
constant: false
is: SBO:0000247
initial amount: NaN
name: Glycerol 3-phosphate
is: C00093
type: Species
is: HMDB00126
has only substance units: false
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
boundary condition: false
initial concentration: 1.0
is: CHEBI:57597

http://identifiers.org/biomodels.db/MODEL1310110012#_bf9eac66_9ab8_49b3_8d98_ab52c0bc13db
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
name: ACADVL
is: P49748
is encoded by: hsa:37
has only substance units: false

metaR RE2445E
is version of: http://identifiers.org/ec-code/3.4.15.1
reactant: MODEL1310110012#
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (1636.1) or (59272.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.15.1 Confidence Level: 0 AUTHORS: PMID:11244003 NOTES:
product: MODEL1310110012#
modifier: MODEL1310110012#
name: RE2445
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.17.23

http://identifiers.org/biomodels.db/MODEL1310110012#_5f58c273_3822_48e1_a473_f7cfac560569
has part: P57054
has part: B2RAU6
is encoded by: hsa:5277
initial concentration: NaN
is: SBO:0000297
initial amount: NaN
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
boundary condition: true
is encoded by: hsa:51227
is encoded by: hsa:9091
constant: false
type: Species
is encoded by: hsa:5279
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_ff8f3e79_75dc_41e1_a536_cb7f8374408c
constant: false
type: Species
name: VNN2
has only substance units: false
is: O95498
is encoded by: hsa:8875
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR HYXNt
is: SBO:0000185
type: Reaction
modifier: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
reactant: MODEL1310110012#
reversible: true
kinetic law: MODEL1310110012#
is described by: ECO:0000269
product: MODEL1310110012#
name: Hypoxanthine transport

http://identifiers.org/biomodels.db/MODEL1310110012#_26c8f2fa_4596_4e28_88bf_1e1e6c9f61a2
name: ATP5G3
has only substance units: false
initial concentration: NaN
is encoded by: hsa:518
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_feb6ea02_a20d_4b83_abc9_0d2df04da1e9
is: SBO:0000297
is encoded by: hsa:482
name: ATP1A3:ATP1B2
constant: false
has part: P14415
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_af785740_e270_4959_b499_04866c72d105
initial amount: NaN
is: Q8IW54
name: PDE2A
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5138
constant: false
boundary condition: true

metaM cholcoar x
initial amount: NaN
boundary condition: false
is: CHEBI:58677
initial concentration: 1.0
is: HMDB02178
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
has only substance units: false
is: SBO:0000247
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
type: Species
constant: false

metaM bildglcur e
initial amount: NaN
name: bis(beta-glucosyluronate)bilirubin
is: HMDB03325
boundary condition: false
is: SBO:0000247
is: CHEBI:58471
type: Species
constant: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
initial concentration: 1.0
has only substance units: false

metaM tyr L c
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00158
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: CHEBI:17895
name: L-tyrosine
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN

metaM 3ivcoa c
is: HMDB06870
type: Species
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/11966188
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
is: C05998
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
name: 3-hydroxyisovalerylcoa

http://identifiers.org/biomodels.db/MODEL1310110012#_a243a6df_cc75_40f2_8fd9_3f63f2870f94
boundary condition: true
is: B7Z763
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:272
name: AMPD3

metaR r0009
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
reversible: false
is: SBO:0000176
fast: false
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.6.1.1
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110012#

metaM gdp c
is: CHEBI:58189
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
is: HMDB01201
is: C00035
has only substance units: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
boundary condition: false
name: GDP

http://identifiers.org/biomodels.db/MODEL1310110012#_681a6127_2a71_4546_9227_19599aa9cdf0
type: Species
initial concentration: NaN
is encoded by: hsa:84076
initial amount: NaN
is: SBO:0000252
is: Q9H0I9
constant: false
boundary condition: true
name: TKTL2
has only substance units: false

metaR ADNCYC
is version of: http://identifiers.org/ec-code/4.6.1.1
name: adenylate cyclase
reactant: MODEL1310110012#
is: SBO:0000176
type: Reaction
product: MODEL1310110012#
fast: false
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110012#_2f50e80f_387e_45cf_8e40_62a08f7f4883
is encoded by: hsa:10317
type: Species
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: B3GALT5
is: SBO:0000252

metaM succoa x
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
is: HMDB01022
constant: false
name: Succinyl-CoA
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_687a297b_d72f_4176_9548_3c7bc88557e0
is: O95622
constant: false
is: SBO:0000252
name: ADCY5
boundary condition: true
has only substance units: false
is encoded by: hsa:111
initial concentration: NaN
type: Species
initial amount: NaN

metaR FAOXC184x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:4)x
type: Reaction

metaM bildglcur c
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: HMDB03325
constant: false
type: Species
boundary condition: false
is: CHEBI:58471
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: bis(beta-glucosyluronate)bilirubin

metaM 2octdectecoa x
boundary condition: false
name: 2,6,9,12-octadecatetraenoylcoa
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/5280355
initial concentration: 1.0
constant: false

metaR r1015
product: MODEL1310110012#
name: Na(+)/bile acid cotransporter Active transport
reactant: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110012#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:6469982 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110012#_8cdb9089_7f94_426c_bc89_df170be6ccc1
type: Species
initial amount: NaN
name: UCK2
has only substance units: false
is: Q9BZX2
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:7371

http://identifiers.org/biomodels.db/MODEL1310110012#_3b38c5c5_2e11_43f9_867f_52c959d1e5de
is: SBO:0000252
name: SLC12A6
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:9990
constant: false
is: Q9UHW9

http://identifiers.org/biomodels.db/MODEL1310110012#_266cecfa_8a9c_4215_bccb_ac2d9c09da0a
name: _286297_1_c
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:286297
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_c
is: CHEBI:18287
boundary condition: false
initial concentration: 1.0
type: Species
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
constant: false
has only substance units: false
is: HMDB00174
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
is: SBO:0000247
initial amount: NaN

metaM 3hddcoa c
initial concentration: 1.0
is: HMDB00623
is: SBO:0000247
constant: false
type: Species
has only substance units: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
initial amount: NaN
boundary condition: false
name: (S)-3-Hydroxydodecanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110012#_df6b8dac_334c_4f2e_89ce_4eac8abcaad5
is encoded by: hsa:79646
boundary condition: true
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: Q9H999
initial amount: NaN
name: PANK3
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110012#_91f781ac_c2df_401b_9a0d_7d4f53ff6d68
name: DCK
is encoded by: hsa:1633
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: P27707
boundary condition: true
type: Species
initial concentration: NaN

metaM trdox c
is: C00343
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:18191
type: Species
initial amount: NaN
name: Oxidized thioredoxin
boundary condition: false
constant: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343

metaR r0472
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reactant: MODEL1310110012#
type: Reaction
fast: false
reversible: true
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_774dc923_13e1_4294_80a4_6c674858c209
is: SBO:0000252
initial amount: NaN
name: DGUOK
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:1716
is: Q16854
boundary condition: true

metaM acnacngalgbside hs e
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: CHEBI:3338
type: Species
is: HMDB00223
is: C00036
initial amount: NaN
name: disialyl galactosylgloboside
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_metaR_FUCFUCFUCGALACGLC13GALACGLCGAL14ACGLCGALGLUSIDEte
name: blood group intracellular transport
kinetic law: MODEL1310110012#
is: SBO:0000185
reversible: true
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
fast: false
reactant: MODEL1310110012#
type: Reaction
is described by: ECO:0000000

metaM 34hpp m
is: HMDB00707
name: 3-(4-hydroxyphenyl)pyruvate
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:36242
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179

http://identifiers.org/biomodels.db/MODEL1310110012#_818ae300_7897_4b78_bec5_852efd532134
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
name: CTPS1
has only substance units: false
is encoded by: hsa:1503
is: P17812
constant: false

metaR r1014
type: Reaction
reactant: MODEL1310110012#
is: SBO:0000185
fast: false
reversible: false
kinetic law: MODEL1310110012#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
is described by: ECO:0000000
product: MODEL1310110012#

metaM pyr x
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
constant: false
is: HMDB00243
is: C00022
type: Species
is: CHEBI:15361
initial concentration: 1.0
initial amount: NaN
name: pyruvate
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3324

http://identifiers.org/biomodels.db/MODEL1310110012#_e7e124fa_1bde_4ef8_875c_6f8197495d6f
is: SBO:0000252
type: Species
constant: false
name: HSD17B10
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:3028
is: Q99714
initial amount: NaN

metaM gdp m
is: C00035
is: HMDB01201
is: SBO:0000247
initial concentration: 1.0
name: GDP
has only substance units: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
constant: false
type: Species
initial amount: NaN
is: CHEBI:58189
boundary condition: false

metaM glutcoa m
is: SBO:0000247
constant: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
has only substance units: false
type: Species
name: glutaryl-CoA(5-)
initial amount: NaN
is: HMDB01339
boundary condition: false
is: CHEBI:57378
initial concentration: 1.0

metaM ksii core2 deg4 l
is: SBO:0000247
boundary condition: false
is: CHEBI:16953
name: keratan sulfate II (core 2-linked), degradation product 4
is: HMDB00812
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C58H95N5O43SX CHARGE: -1
type: Species
has only substance units: false
constant: false

metaM methf m
name: (6R)-5,10-methenyltetrahydrofolate
boundary condition: false
constant: false
is: HMDB01354
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57455
is: SBO:0000247
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445

metaR RE2814R
fast: false
kinetic law: MODEL1310110012#
type: Reaction
name: RE2814
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is: SBO:0000176
reactant: MODEL1310110012#
product: MODEL1310110012#

metaM glc D l
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00122
boundary condition: false
type: Species
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: CHEBI:4167
constant: false

metaM pail hs n
name: 1-phosphatidyl-1D-myo-inositol(1-)
has only substance units: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:57880
boundary condition: false

metaM c10crn c
boundary condition: false
is: SBO:0000247
is: HMDB00651
constant: false
has only substance units: false
name: decanoyl carnitine
type: Species
initial concentration: 1.0
notes: FORMULA: C17H33NO4 CHARGE: 0
initial amount: NaN

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaR VD3
is: SBO:0000176
name: Vitamin D3 formation
is described by: ECO:0000134
kinetic law: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_1f3c0c32_c3c6_414b_9335_520cd3bbc7a9
constant: false
is encoded by: hsa:3418
is: P48735
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: IDH2
has only substance units: false
initial amount: NaN
type: Species

metaM gdp n
is: SBO:0000247
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
boundary condition: false
name: GDP(3-)
is: CHEBI:58189
has only substance units: false
is: HMDB01201
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_c01a90af_ce89_425a_a96d_6f04f5d0a186
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is: P09622
initial concentration: NaN
type: Species
initial amount: NaN
name: DLD
is encoded by: hsa:1738

metaR r1013
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
reversible: false
kinetic law: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Transport reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_e
is: C00095
is: CHEBI:15824
is: HMDB00660
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
has only substance units: false
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0

metaR PCHOL HSter
is: SBO:0000185
kinetic law: MODEL1310110012#
reversible: true
name: phosphatidylcholine scramblase
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
type: Reaction
fast: false
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110012#_ba2469ac_6a56_40ce_a218_5a3310639b50
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q01959
name: SLC6A3
is encoded by: hsa:6531
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_a82a67ea_87dd_4ae1_9b0d_bacacb0bd69b
name: UROD
is: P06132
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:7389
type: Species
initial concentration: NaN
initial amount: NaN

metaR FAOXC225C204x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_12491911_f470_4bf2_8319_1792cc044ff3
is: SBO:0000252
is: Q9UBY0
has only substance units: false
name: SLC9A2
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:6549
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_4579ca18_7b3d_42fc_b27d_1b603c8e2b2a
has only substance units: false
is: SBO:0000252
name: IVD
initial amount: NaN
constant: false
is encoded by: hsa:3712
type: Species
initial concentration: NaN
is: B3KVI7
boundary condition: true

metaR r0474
reactant: MODEL1310110012#
reversible: true
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
product: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110012#

metaM acnacngalgbside hs c
name: disialyl galactosylgloboside
is: HMDB00223
has only substance units: false
boundary condition: false
is: C00036
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:3338

metaM 10fthf5glu e
is: HMDB00972
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000247
is: CHEBI:57454
initial concentration: 1.0
name: 10-formyltetrahydrofolate-[Glu](5)
notes: FORMULA: C40H45N11O19 CHARGE: -6

metaR GLUNm
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110012#
product: MODEL1310110012#
name: glutaminase (mitochondrial)
is version of: http://identifiers.org/ec-code/3.5.1.2
reversible: false
notes: GENE_ASSOCIATION: (2744.1) or (27165.2) or (27165.1) SUBSYSTEM: Glutamate metabolism EC Number: 3.5.1.2 Confidence Level: 4 AUTHORS: PMID:10719215,PMID:12579526 NOTES:
is: SBO:0000176
type: Reaction

metaR r1012
is described by: ECO:0000000
type: Reaction
reversible: false
kinetic law: MODEL1310110012#
fast: false
reactant: MODEL1310110012#
is: SBO:0000185
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
product: MODEL1310110012#

metaR RBTt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110012#
is: SBO:0000185
fast: false
reactant: MODEL1310110012#
name: ribitol transport via passive diffusion
reversible: false
product: MODEL1310110012#
type: Reaction
is described by: ECO:0000000

metaM dec24dicoa x
boundary condition: false
is: SBO:0000247
constant: false
name: 2,4-decadienoylcoa
has only substance units: false
is: HMDB01168
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0
initial amount: NaN

metaR CHATn
is described by: ECO:0000269
reactant: MODEL1310110012#
name: Choline O-acetyltransferase
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.6
fast: false
modifier: MODEL1310110012#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_88073bd9_c8c7_49f8_9375_17c2587d2b47
boundary condition: true
type: Species
is: SBO:0000252
name: GALE
is: Q38G75
is encoded by: hsa:2582
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM cholcoar r
initial concentration: 1.0
boundary condition: false
is: HMDB02178
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
has only substance units: false
type: Species
is: SBO:0000247
constant: false
is: CHEBI:58677
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
initial amount: NaN

metaR AG13T12g
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
modifier: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
product: MODEL1310110012#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR r0475
type: Reaction
product: MODEL1310110012#
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
kinetic law: MODEL1310110012#

metaM ksi pre5 g
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C101H164N7O75SX CHARGE: -2
name: keratan sulfate I biosynthesis, precursor 5
type: Species
initial amount: NaN
is: CHEBI:28067
constant: false
is: SBO:0000247
boundary condition: false

metaR G14T2g
product: MODEL1310110012#
modifier: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110012#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90

metaR MANtly
kinetic law: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110012#
name: mannose efflux from lysosome
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reversible: false
reactant: MODEL1310110012#

metaM tyr L m
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00158
name: L-tyrosine
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial concentration: 1.0
is: CHEBI:17895
constant: false
boundary condition: false

metaR RE2666C
name: RE2666
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
fast: false

metaR r1011
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
name: Transport reaction
reversible: false
fast: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110012#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110012#_cb6c9ae4_5b75_49c3_ba57_2ae119de94a9
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3658
initial amount: NaN
name: IREB2
type: Species
is: P48200
constant: false
has only substance units: false
is: SBO:0000252

metaM CE5119 m
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
name: trans-3-cis-8-tetradecadienoyl-CoA
is: CHEBI:57923
initial amount: NaN

metaR BILDGLCURtr
reactant: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
reversible: true
product: MODEL1310110012#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110012#
is described by: ECO:0000000
name: glucuronidated compound transport

metaR FAOXC163x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)x
type: Reaction

metaM idp n
name: IDP(3-)
is: HMDB03335
constant: false
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58280

metaR EX 4pyrdx LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Pyridoxate exchange
type: Reaction

metaR FAOXC225C226x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_25d8b322_789e_4e92_b97d_9a08204a3929
is encoded by: hsa:386757
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: SLC6A10P
is: SBO:0000252
boundary condition: true
type: Species

metaR ATP2ter
product: MODEL1310110012#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110012#
fast: false
name: AMP/ATP transporter, endoplasmic reticulum
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110012#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110012#_0b8f09a2_a4ee_4453_9499_1e3df562c09c
name: KYNU
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: Q16719
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8942
constant: false

metaM 6pgl r
constant: false
has only substance units: false
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
initial concentration: 1.0
type: Species
is: CHEBI:57955
is: HMDB01127

http://identifiers.org/biomodels.db/MODEL1310110012#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00174
constant: false
is: CHEBI:18287
initial concentration: 1.0
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110012#_2aae6180_ff4f_426b_8741_f47b68ec665f
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q6NVC0
initial concentration: NaN
is encoded by: hsa:292
name: SLC25A5
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_45b6acc2_b0de_4fd7_8846_cd91d97028cd
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:366
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: O43315
name: AQP9
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_aa1d0338_549f_4b32_8971_10cf3547c1fb
name: GSR
is: P00390
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2936
has only substance units: false
boundary condition: true

metaR r2360
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110012#
is: SBO:0000185
kinetic law: MODEL1310110012#
reversible: true
product: MODEL1310110012#
name: Organic anion transporter 5 Utilized transport

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

metaR r1010
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
kinetic law: MODEL1310110012#
product: MODEL1310110012#
name: Postulated transport reaction
reactant: MODEL1310110012#
is: SBO:0000185
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110012#_cae6700e_4016_41f0_8419_fee4a762d9ed
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
name: B3GALT5
initial concentration: NaN
constant: false
is encoded by: hsa:10317
initial amount: NaN

metaR GPIDAer
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
product: MODEL1310110012#
reversible: false
fast: false
is described by: ECO:0000000
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
kinetic law: MODEL1310110012#
type: Reaction

metaR r0051
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
reversible: true
fast: false
product: MODEL1310110012#
reactant: MODEL1310110012#
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
kinetic law: MODEL1310110012#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.5

http://identifiers.org/biomodels.db/MODEL1310110012#_metaM_acgalfuc12gal14acglcgalgluside_hs_g
initial amount: NaN
is: HMDB00304
is: CHEBI:57847
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C58H102N3O31FULLRCO CHARGE: 0

metaM hpdca c
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
boundary condition: false
type: Species
is: HMDB02259
has only substance units: false
initial concentration: 1.0
is: CHEBI:32366
initial amount: NaN
constant: false
is: SBO:0000247
name: margarate

http://identifiers.org/biomodels.db/MODEL1310110012#_45809b11_0e4d_4032_9e19_3a1c37d54b29
is: Q9BYC5
initial amount: NaN
is encoded by: hsa:2530
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
name: FUT8
constant: false
is: SBO:0000252

metaR EX ahdt LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 7,8-dihydroneopterin 3-triphosphate(4-)
type: Reaction

metaR CYTDtn
kinetic law: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: cytidine transport in nucleus
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110012#
product: MODEL1310110012#

metaR r2361
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110012#
reactant: MODEL1310110012#
name: Organic anion transporter 5 Utilized transport
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110012#
reversible: true

metaR 5OXPROt
reversible: true
reactant: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 5-oxoprolinate
fast: false
kinetic law: MODEL1310110012#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_b0c19e55_08bc_4d36_8c64_39927b460252
is: Q9P019
constant: false
boundary condition: true
initial amount: NaN
name: PHPT1
initial concentration: NaN
is encoded by: hsa:29085
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_90987066_0d9e_4780_9a14_9cb93e36b5b9
name: LSS
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is: E9PEI9
initial concentration: NaN
is encoded by: hsa:4047
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_494c5cc4_68d5_48b9_9ed9_527c7fa5dbf6
has only substance units: false
is: P43353
name: ALDH3B1
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:221
initial amount: NaN
boundary condition: true

metaM ksii core2 deg7 l
type: Species
is: CHEBI:16953
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 7
initial amount: NaN
notes: FORMULA: C44H73N4O30X CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
is: HMDB00812
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_411328ae_c792_414e_9b40_5cb996f7442c
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
is: Q9P2T1
initial concentration: NaN
name: GMPR2
is encoded by: hsa:51292
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_dcdd2160_d666_433a_9472_7d7816d96158
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
name: SLC5A5
is: Q92911
has only substance units: false
is encoded by: hsa:6528
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_41c69d38_b9f5_490f_abc8_bf2c4664de13
initial concentration: NaN
has only substance units: false
is: P08195
initial amount: NaN
boundary condition: true
type: Species
name: SLC3A2
constant: false
is: SBO:0000252
is encoded by: hsa:6520

metaM 3octdece1coa c
is: HMDB13336
constant: false
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
name: 3-hydroxyoctadecenoylcoa
is: SBO:0000247
initial concentration: 1.0

metaM apoC Lys c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H13N2OX CHARGE: 0
is: HMDB00182
is: SBO:0000247
name: Apocarboxylase (Lys residue)
type: Species
has only substance units: false
is: CHEBI:32551
constant: false

metaR CYTDtm
is: SBO:0000185
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
reversible: true
is described by: ECO:0000269
product: MODEL1310110012#
modifier: MODEL1310110012#
type: Reaction
fast: false
name: cytidine facilated transport in mitochondria

http://identifiers.org/biomodels.db/MODEL1310110012#_1a3852e7_2b77_4038_9534_d92d9f4426e8
type: Species
initial concentration: NaN
initial amount: NaN
name: GBA
is: SBO:0000252
constant: false
is: B7Z6S9
is encoded by: hsa:2629
has only substance units: false
boundary condition: true

metaR LCADi
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110012#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.36
name: lactaldehyde dehydrogenase
modifier: MODEL1310110012#

metaR r2362
kinetic law: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110012#
reactant: MODEL1310110012#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_c5a63eb9_02d1_41a0_b759_da7d5984080b
is: Q9NS18
name: GLRX2
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:51022
is: SBO:0000252
initial concentration: NaN
constant: false

metaM glc D e
is: HMDB00122
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:4167
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_7085f29b_676e_41a7_92aa_a495707009e1
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
name: _H45672_1_m
initial concentration: NaN
has only substance units: false
is encoded by: hsa:H45672

metaR r1569
product: MODEL1310110012#
kinetic law: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110012#

metaM acnacngalgbside hs g
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:3338
is: HMDB00223
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
initial amount: NaN
is: C00036
name: disialyl galactosylgloboside
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_123d70e3_4ab3_43af_a9ae_5d49eddda154
has only substance units: false
is: SBO:0000252
is encoded by: hsa:9091
is: B2RAU6
name: PIGQ
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_75bac997_79e6_44b3_b48a_1904cc1c4cbc
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
has part: O95497
is encoded by: hsa:8876
type: Species
name: VNN3:VNN2:VNN1
has only substance units: false
boundary condition: true
is encoded by: hsa:55350
is encoded by: hsa:8875
has part: A8K7W0
constant: false

metaR TMNDNCCRNt
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
name: transport into the mitochondria (carnitine)
reactant: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110012#_7b65dbfb_d9c3_4fcb_8a17_6856647499db
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
name: PIP4K2B
is: P78356
has only substance units: false
is encoded by: hsa:8396
initial amount: NaN
type: Species

metaM dhlam m
initial concentration: 1.0
is: CHEBI:17694
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
name: dihydrolipoamide
type: Species
is: HMDB00985
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_cddda0fe_0140_465e_8800_fac89f153039
name: CHST4
initial amount: NaN
is: SBO:0000252
is: Q8NCG5
type: Species
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:10164

metaM hpdca e
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
has only substance units: false
is: HMDB02259
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:32366
name: margarate
boundary condition: false

metaM 56dura c
is: SBO:0000247
initial amount: NaN
is: HMDB00076
name: 5,6-dihydrouracil
initial concentration: 1.0
is: CHEBI:15901
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
has only substance units: false
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_bed02382_89a2_47cc_88b0_a368a173b2f3
has part: P00325
is: SBO:0000297
boundary condition: true
initial amount: NaN
is encoded by: hsa:124
name: ADH1A:ADH1B
type: Species
is encoded by: hsa:125
has only substance units: false
constant: false
initial concentration: NaN
has part: P07327

metaM c10crn e
notes: FORMULA: C17H33NO4 CHARGE: 0
name: decanoyl carnitine
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00651
has only substance units: false
initial concentration: 1.0

metaM Lpipecol x
boundary condition: false
initial amount: NaN
is: HMDB00716
has only substance units: false
name: L-pipecolic acid
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:30913
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408

http://identifiers.org/biomodels.db/MODEL1310110012#_db54a2f3_b5d3_4dfe_8beb_271ba9921531
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species
name: PDE9A
is encoded by: hsa:5152

http://identifiers.org/biomodels.db/MODEL1310110012#_9dd52c77_d153_4f73_ad1c_a45ad3d8a865
is: P17707
initial concentration: NaN
boundary condition: true
is encoded by: hsa:262
has only substance units: false
name: AMD1
type: Species
constant: false
is: SBO:0000252
initial amount: NaN

metaR EX 3octdece1crn
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-octadecenoyl carnitine
type: Reaction

metaR r1553
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110012#
fast: false

metaM bhb e
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: HMDB00011
has only substance units: false
constant: false
name: (R)-3-hydroxybutyrate
initial concentration: 1.0
boundary condition: false
is: CHEBI:10983

metaR ADRNt
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000185
type: Reaction
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaM cspg a l
initial amount: NaN
boundary condition: false
constant: false
is: HMDB02183
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
has only substance units: false
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
is: CHEBI:36005
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR FAOXC16180m
is: SBO:0000176
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
name: Beta oxidation fatty acid
reactant: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110012#_7ca2c147_45eb_4a29_bc0a_a6154cd2cce6
constant: false
is: SBO:0000252
name: UCK1
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:83549
has only substance units: false
is: Q5JT09

metaR r0603
fast: false
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
kinetic law: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.12
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110012#
modifier: MODEL1310110012#
product: MODEL1310110012#
reversible: true

metaM glutcoa c
has only substance units: false
boundary condition: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1
constant: false
is: HMDB01339
name: glutaryl-CoA(5-)
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM sphmyln hs c
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:58216
initial concentration: 1.0
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
name: sphingomyelin betaine
is: SBO:0000247
has only substance units: false

metaR r2366
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110012#
type: Reaction
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110012#
is: SBO:0000185
reactant: MODEL1310110012#

metaM pmtcoa c
is: C00154
initial amount: NaN
is: HMDB01338
boundary condition: false
constant: false
name: Palmitoyl-CoA (n-C16:0CoA)
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:3454
initial concentration: 1.0

metaR RETNt
name: retinoic acid transport
type: Reaction
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
fast: false
product: MODEL1310110012#
reversible: true
kinetic law: MODEL1310110012#
is described by: ECO:0000000
is: SBO:0000185

metaR EX 5homeprazole LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5 hydroxy omeprazole exchange
type: Reaction

metaM drib c
initial amount: NaN
name: 2-deoxy-D-ribose
has only substance units: false
type: Species
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
boundary condition: false
constant: false
is: CHEBI:28816
is: SBO:0000247
is: HMDB03224
initial concentration: 1.0

metaR FUMtm
name: fumarate transport, mitochondrial
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is: SBO:0000185
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV

metaR r1554
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110012#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
reversible: true

metaM succoa c
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB01022
boundary condition: false
is: SBO:0000247
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
name: Succinyl-CoA
constant: false

metaM pyr m
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
type: Species
initial concentration: 1.0
name: pyruvate
boundary condition: false
is: SBO:0000247
is: C00022
is: HMDB00243
is: http://identifiers.org/pubchem.compound/3324
constant: false
is: CHEBI:15361

metaM ksi pre23 g
is: CHEBI:28067
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 23

metaM acgpail hs c
initial concentration: 1.0
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:57265
constant: false
type: Species
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
is: SBO:0000247

metaR S6TASE26ly
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000176
type: Reaction
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_cfad9bd2_2ecc_4213_849b_9c04cb1fc956
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:1593
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q02318
name: CYP27A1

metaR HEX7
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.1.1
product: MODEL1310110012#
name: hexokinase (D-fructose:ATP)
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.2
is described by: ECO:0000304
fast: false
modifier: MODEL1310110012#
reversible: false
kinetic law: MODEL1310110012#
type: Reaction

metaR ACRNtm
modifier: MODEL1310110012#
product: MODEL1310110012#
reversible: false
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:977593 NOTES:NCD
name: O-acetylcarnintine transport into mitochondria via diffusion
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
fast: false

metaR r2365
kinetic law: MODEL1310110012#
is: SBO:0000185
reversible: true
reactant: MODEL1310110012#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110012#
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110012#_8721db14_d39e_4280_bc70_a9113b5811c0
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: Q59HH3
name: GART
is: SBO:0000252
is encoded by: hsa:2618

metaR GALASE10ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110012#_a10307aa_1307_46ca_be31_3bfee90b9f9b
is encoded by: hsa:3030
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: E9KL44
boundary condition: true
initial amount: NaN
name: HADHA

metaM acgam1p c
is: CHEBI:7125
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: HMDB01367
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
name: N-Acetyl-D-glucosamine 1-phosphate

metaM bhb c
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: (R)-3-hydroxybutyrate
initial concentration: 1.0
is: HMDB00011
boundary condition: false
constant: false
is: CHEBI:10983

metaR r0055
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.7
reversible: true
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.2.8
product: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#

metaM HC01672 c
is: SBO:0000247
name: Acetyl adenylate
is: CHEBI:37666
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C12H15N5O8P CHARGE: -1 INCHI: InChI=1S/C12H16N5O8P/c1-5(18)25-26(21,22)23-2-6-8(19)9(20)12(24-6)17-4-16-7-10(13)14-3-15-11(7)17/h3-4,6,8-9,12,19-20H,2H2,1H3,(H,21,22)(H2,13,14,15)/t6-,8-,9-,12-/m1/s1 EHMN_ABBREVIATION: C05993
has only substance units: false
boundary condition: false
constant: false

metaR EX ddecrn
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lauroyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_a1dd6e67_ce82_4784_a491_5d96ec4b3e95
is encoded by: hsa:2271
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
name: FH
is: SBO:0000252
is: P07954
type: Species
initial concentration: NaN

metaR r2364
is described by: ECO:0000000
kinetic law: MODEL1310110012#
type: Reaction
reversible: true
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110012#

metaM bilglcur r
initial concentration: 1.0
constant: false
name: mono(glucosyluronic acid)bilirubin(2-)
boundary condition: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57767
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_0b9741ce_a300_4ebc_875f_932ddb82751f
initial concentration: NaN
name: GMPPB
is: Q9Y5P6
has only substance units: false
initial amount: NaN
is encoded by: hsa:29925
boundary condition: true
is: SBO:0000252
type: Species
constant: false

metaM creat e
type: Species
initial amount: NaN
has only substance units: false
name: creatine
constant: false
is: CHEBI:16919
is: HMDB00064
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_14e5b784_0296_47fa_927b_07875e281ad8
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaM galgluside hs g
is: HMDB00295
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
boundary condition: false
constant: false
name: galactosyl glucosyl ceramide
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58223
is: SBO:0000247
has only substance units: false
is: C00015
type: Species

metaR HEX4
reactant: MODEL1310110012#
fast: false
is described by: ECO:0000304
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.1
is version of: http://identifiers.org/ec-code/2.7.1.2
is: SBO:0000176
name: hexokinase (D-mannose:ATP)
type: Reaction
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
product: MODEL1310110012#
kinetic law: MODEL1310110012#

metaR r2363
kinetic law: MODEL1310110012#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110012#
is: SBO:0000185
fast: false
reactant: MODEL1310110012#
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110012#_ada3e96b_5a46_457c_bac3_f4605d498fe8
initial concentration: NaN
has only substance units: false
is: Q6IB04
is: SBO:0000252
initial amount: NaN
name: PIGF
boundary condition: true
is encoded by: hsa:5281
type: Species
constant: false

metaR TRDR
reversible: false
fast: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.8.1.9
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110012#
name: thioredoxin reductase (NADPH)
is: SBO:0000176
type: Reaction
modifier: MODEL1310110012#

metaR r1556
type: Reaction
kinetic law: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110012#
reactant: MODEL1310110012#
fast: false
is: SBO:0000185

metaM hestratriol r
is: SBO:0000247
constant: false
name: 4,17 dihydroxy estradiol
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
is: HMDB05896
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false

metaR FAOXC122x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)x
type: Reaction

metaR CYTK10
type: Reaction
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110012#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110012#
fast: false
modifier: MODEL1310110012#
name: cytidylate kinase (CMP,dGTP)
is: SBO:0000176

metaR XOL7AH2tm
kinetic law: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110012#
is described by: ECO:0000000
reactant: MODEL1310110012#
is: SBO:0000185
type: Reaction
reversible: true
name: lipid, flip-flop intracellular transport

metaR RE1520M
kinetic law: MODEL1310110012#
name: RE1520
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110012#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110012#
is described by: ECO:0000000
modifier: MODEL1310110012#
is: SBO:0000176

metaR C12OHc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdodecanoylcarnitinec
type: Reaction

metaR GluForTx
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.5
reactant: MODEL1310110012#
product: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
is: SBO:0000176
name: Glutamate formimidoyltransferase
kinetic law: MODEL1310110012#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_8cd249bb_8ef1_4502_b913_ebe00912e90b
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:2629
is: P04062
initial amount: NaN
name: GBA
boundary condition: true
initial concentration: NaN
constant: false

metaR HEX1
name: hexokinase (D-glucose:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.2
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
modifier: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.1
is: SBO:0000176
type: Reaction
reactant: MODEL1310110012#
product: MODEL1310110012#

metaR O2t
type: Reaction
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
product: MODEL1310110012#
name: o2 transport (diffusion)
kinetic law: MODEL1310110012#

metaM glyald m
name: D-glyceraldehyde
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: CHEBI:17378
is: HMDB01051
initial amount: NaN
type: Species
is: SBO:0000247

metaM ksi pre26 g
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 26
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
type: Species
is: CHEBI:28067

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_metaR_FUCFUCFUCGALACGLC13GALACGLCGAL14ACGLCGALGLUSIDEtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
type: Reaction
reactant: MODEL1310110012#
reversible: true
kinetic law: MODEL1310110012#
product: MODEL1310110012#
fast: false
is: SBO:0000185
name: blood group intracellular transport
is described by: ECO:0000000

metaM udpg c
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: HMDB00286
is: CHEBI:58367
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
name: UDPglucose
initial amount: NaN
is: C00029
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_3ddc8fe1_127f_466e_9324_02364658ab0b
is: P19367
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3098
constant: false
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
name: HK1

metaR RE1807C
kinetic law: MODEL1310110012#
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reversible: true
name: RE1807

metaR AG13T16g
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
type: Reaction
reactant: MODEL1310110012#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110012#_401b9bac_f0be_4e4f_bf23_4a3c67831044
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
name: SLC35A1
constant: false
initial amount: NaN
is: SBO:0000252
is: P78382
is encoded by: hsa:10559

metaR CLOXAtex2
product: MODEL1310110012#
is described by: ECO:0000304
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
reversible: false
is: SBO:0000185
name: chloride transport via oxalate countertransport (2:1)

http://identifiers.org/biomodels.db/MODEL1310110012#_2aa3ac26_2529_4572_997d_01e3379efe0c
name: NME4
initial concentration: NaN
is encoded by: hsa:4833
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is: O00746
boundary condition: true

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaM tethex3coa x
boundary condition: false
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
type: Species
is: HMDB06243
is: http://identifiers.org/pubchem.compound/47205478
constant: false
initial concentration: 1.0
name: tetracosahexaenoyl coenzyme A
is: C16168
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM sphmyln hs g
type: Species
name: sphingomyelin betaine
initial amount: NaN
has only substance units: false
is: CHEBI:58216
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007

metaR CYTK11
reversible: true
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110012#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110012#
type: Reaction
fast: false
name: cytidylate kinase (dCMP,dGTP)

http://identifiers.org/biomodels.db/MODEL1310110012#_b5b8981c_292b_4f34_abdb_ac600e223580
constant: false
name: _H17063_1_c
is encoded by: hsa:H17063
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR GPDDA1
fast: false
reversible: false
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
kinetic law: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.46 Confidence Level: 0 AUTHORS: NOTES:JLR
is described by: ECO:0000000

metaR C16DCe
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexadecanedioic acid mono-L-carnitine ester into extra cellular space
type: Reaction

metaR THRCYSNaEx
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110012#
is described by: ECO:0000269
reactant: MODEL1310110012#
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110012#
name: L-cysteine/L-threonine Na-dependent exchange (Thr-L in)
product: MODEL1310110012#
is: SBO:0000185

metaR DHEASULT
fast: false
is: SBO:0000176
product: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.8.2.14
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: false
name: Dehydroepiandrosterone sulfotransferase
notes: GENE_ASSOCIATION: (6783.1) or (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:1588921 NOTES:NJ
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.8.2.4

metaR r2369
reactant: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110012#
name: Organic anion transporter 5 Utilized transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaR S6TASE15ly
kinetic law: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110012#
fast: false

metaR 4PYRDX
is: SBO:0000185
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT Reaction correct??? (active transport)
reactant: MODEL1310110012#
is described by: ECO:0000000
name: 4-Pyridoxal secretion
fast: false

metaM amp m
type: Species
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:456215
is: HMDB00045
constant: false
name: AMP(2-)
is: SBO:0000247

metaM ps hs e
boundary condition: false
is: SBO:0000247
is: CHEBI:18303
name: phosphatidylserine
initial amount: NaN
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
type: Species
constant: false
has only substance units: false
initial concentration: 1.0

metaR F1PGT
modifier: MODEL1310110012#
product: MODEL1310110012#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.30
reactant: MODEL1310110012#
name: fucose-1-phosphate guanylyltransferase
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176

metaR Htx
fast: false
product: MODEL1310110012#
is: SBO:0000185
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
type: Reaction
name: H transporter, peroxisome
reactant: MODEL1310110012#
reversible: true
is described by: ECO:0000000

metaM m3mpdol U c
initial amount: NaN
type: Species
boundary condition: false
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human uterine homolog
constant: false
initial concentration: 1.0
notes: FORMULA: C1425H2340N20O370P20 CHARGE: -20
has only substance units: false
is: SBO:0000247
is: CHEBI:37632

metaM rbt e
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: HMDB00508
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: CHEBI:15963
name: D-ribitol
has only substance units: false
boundary condition: false

metaM galgluside hs l
name: galactosyl glucosyl ceramide
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:12936
has only substance units: false
is: HMDB00143
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
type: Species
initial amount: NaN
is: SBO:0000247

metaR CYTK12
name: cytidylate kinase (dCMP,dCTP)
is described by: ECO:0000269
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
kinetic law: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#

metaR GLCURtly
name: glucuronate transport into lysososme
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
type: Reaction
kinetic law: MODEL1310110012#
is described by: ECO:0000269
product: MODEL1310110012#
reversible: true
modifier: MODEL1310110012#
fast: false
is: SBO:0000185
reactant: MODEL1310110012#

metaR r1551
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110012#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110012#_70391479_3aaa_4d06_9872_2496caec8fc3
constant: false
type: Species
is: SBO:0000252
name: CYP1A1
initial amount: NaN
is: A0N0X8
has only substance units: false
boundary condition: true
is encoded by: hsa:1543
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_1399bff1_138f_4bf9_a6cf_faf3a9b79b60
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: ALG3
type: Species
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:10195

http://identifiers.org/biomodels.db/MODEL1310110012#_4464c959_ebad_4c7b_960f_00f5cdad8ce0
type: Species
initial concentration: NaN
boundary condition: true
is: Q16836
name: HADH
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:3033

metaR RETH
type: Reaction
reactant: MODEL1310110012#
reversible: false
product: MODEL1310110012#
name: retinyl ester hydrolase
kinetic law: MODEL1310110012#
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT
is version of: http://identifiers.org/ec-code/3.1.1.3
modifier: MODEL1310110012#

metaR ARACHCOAtx
product: MODEL1310110012#
name: fatty acid intracellular transport
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110012#
reversible: true
kinetic law: MODEL1310110012#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaR PSSA1 hs
fast: false
name: Phosphatidylserine synthase homo sapiens
type: Reaction
reactant: MODEL1310110012#
product: MODEL1310110012#
reversible: true
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.8.29
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#

metaR r2368
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110012#
type: Reaction
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_42da6209_dedd_4cd7_ad16_db540acb046a
is encoded by: hsa:AA278423
name: _AA278423_1_c
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_8d59d504_5247_4d9d_9042_08b78c8faebb
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:AU149534
name: _AU149534_1_c
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_1ae7762f_0c1b_47e0_a45e_727f7f17e611
boundary condition: true
name: HSD17B4
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:3295
is: E9PB82
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

metaR C16DCc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexadecanedioylcarnitine
type: Reaction

metaR CYTK13
reversible: true
reactant: MODEL1310110012#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110012#
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dATP)
fast: false
kinetic law: MODEL1310110012#

metaR r1552
reactant: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110012#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM drib e
is: HMDB03224
type: Species
name: 2-deoxy-D-ribose
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
constant: false
is: CHEBI:28816
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM L2aadp6sa c
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:17917
is: HMDB01263
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
name: L-allysine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_bda423e9_4759_4ee8_b767_d611978b9a3a
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:80339
name: PNPLA3
is: Q9NST1
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR r2367
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110012#

metaM 6dhf e
initial concentration: 1.0
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
is: HMDB06563
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
name: hexaglutamyl folate (DHF)

http://identifiers.org/biomodels.db/MODEL1310110012#_a89794d9_6492_4c0e_abe1_643ba30387b0
boundary condition: true
is: P22352
name: GPX3
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2878
type: Species
initial amount: NaN

metaR EX mthgxl LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Methylglyoxal exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_dd22d72c_d999_4c2f_9b9f_e7e6d73f56ca
name: PGM1
initial concentration: NaN
is encoded by: hsa:5236
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is: B4DPV0
has only substance units: false
initial amount: NaN

metaR GTMLTe
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.2.2
reversible: false
name: g-glutamyltransferase (e)
modifier: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
is: SBO:0000185
notes: GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES:NCD SAB e see Disussion section of PMID 15469854
reactant: MODEL1310110012#
is described by: ECO:0000269
fast: false

metaM pail hs c
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: CHEBI:57880
type: Species
is: SBO:0000247
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
initial concentration: 1.0

metaM dcdp c
is: CHEBI:58593
boundary condition: false
type: Species
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
name: dCDP
is: HMDB01245
is: SBO:0000247
constant: false
is: C00705
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR DPCOAtl
is described by: ECO:0000000
product: MODEL1310110012#
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
reversible: true
name: dephospho-CoA transport from lysosome via diffusion
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
type: Reaction

metaR ACGAMPM
is version of: http://identifiers.org/ec-code/5.4.2.3
is described by: ECO:0000269
is: SBO:0000176
name: phosphoacetylglucosamine mutase
product: MODEL1310110012#
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD

metaR TMDK1m
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:9342341 NOTES:TV
is described by: ECO:0000269
name: thymidine kinase (ATP:thymidine)
is: SBO:0000176
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.7.1.21
fast: false
product: MODEL1310110012#
reversible: false
type: Reaction

metaM CE5132 c
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
initial concentration: 1.0
constant: false
is: CHEBI:57923
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)

http://identifiers.org/biomodels.db/MODEL1310110012#_24bfa812_1351_468e_8a4a_c4b0261045c2
is encoded by: hsa:33
boundary condition: true
type: Species
initial amount: NaN
is: P28330
constant: false
name: ACADL
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_4cecfff7_e64c_4119_85bd_e6798db8239f
is encoded by: hsa:84720
has only substance units: false
has part: Q6IB04
name: PIGF:PIGO
boundary condition: true
type: Species
is: SBO:0000297
is encoded by: hsa:5281
initial concentration: NaN
initial amount: NaN
constant: false

metaR EX tetpent6 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-6 exchange
type: Reaction

metaM hxcoa x
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00705
initial concentration: 1.0
name: Hexanoyl-CoA (n-C6:0CoA)

metaR CEPTE
type: Reaction
modifier: MODEL1310110012#
reversible: false
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (10390.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.7.8.2
reactant: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000176
name: ethanolamine phosphotransferase
kinetic law: MODEL1310110012#

metaM thp2c x
is: CHEBI:16987
constant: false
has only substance units: false
type: Species
name: 1-piperideine-6-carboxylate
is: SBO:0000247
is: HMDB12130
initial amount: NaN
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
boundary condition: false
initial concentration: 1.0

metaR THYMDtm
fast: false
reversible: true
reactant: MODEL1310110012#
is: SBO:0000185
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:TDV
kinetic law: MODEL1310110012#
type: Reaction
name: thymd transport
modifier: MODEL1310110012#
product: MODEL1310110012#
is described by: ECO:0000269

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaR ECOAH12m
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is described by: ECO:0000304
kinetic law: MODEL1310110012#
product: MODEL1310110012#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
fast: false
modifier: MODEL1310110012#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110012#

metaM bhb m
boundary condition: false
is: CHEBI:10983
has only substance units: false
is: HMDB00011
initial concentration: 1.0
constant: false
name: (R)-3-hydroxybutyrate
is: SBO:0000247
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
initial amount: NaN

metaR ILEt5m
reactant: MODEL1310110012#
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000
name: Isoleucine mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
kinetic law: MODEL1310110012#
fast: false
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_5a0a80a1_1c13_4839_ae16_a3ea9a5b2e13
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:218
type: Species
is: P30838
initial concentration: NaN
constant: false
name: ALDH3A1

http://identifiers.org/biomodels.db/MODEL1310110012#_14b6a877_a3b3_4bd2_be1e_155851ad447c
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:514
name: ATP5E
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_a8e04b22_5edf_46e2_abc0_9a3a479be818
boundary condition: true
is encoded by: hsa:4695
is: O43678
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: NDUFA2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_b64d5941_a2ee_4a47_b6a1_a9642fa12796
name: SLC4A3
constant: false
is: SBO:0000252
has only substance units: false
type: Species
is: P48751
is encoded by: hsa:6508
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR DMATTx
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
is version of: http://identifiers.org/ec-code/2.5.1.1
name: dimethylallyltranstransferase
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110012#
modifier: MODEL1310110012#
product: MODEL1310110012#
fast: false
reversible: false
kinetic law: MODEL1310110012#
type: Reaction

metaR r0317
reversible: true
is version of: http://identifiers.org/ec-code/2.1.2.10
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.4.4.2
type: Reaction
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
kinetic law: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.8.1.4
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is: SBO:0000176
modifier: MODEL1310110012#
is described by: ECO:0000000
reactant: MODEL1310110012#
fast: false

metaM sph1p e
is: HMDB01383
constant: false
has only substance units: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
is: CHEBI:57939
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate

metaM pyr e
name: pyruvate
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00243
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: CHEBI:15361
boundary condition: false

metaM tag hs e
type: Species
is: CHEBI:17855
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
has only substance units: false
boundary condition: false
name: triglyceride
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_21d3a91f_8b5a_4284_9a13_42d24991931b
is encoded by: hsa:8560
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: DEGS1
type: Species
boundary condition: true
constant: false

metaM pail35p hs c
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:57923
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
initial concentration: 1.0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_c137ede5_73d4_40c3_ad50_d66d99aa0f3b
type: Species
initial amount: NaN
is: SBO:0000252
is: F5H123
initial concentration: NaN
name: DYLX2
is encoded by: hsa:9856
constant: false
has only substance units: false
boundary condition: true

metaR RE3568C
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110012#
is described by: ECO:0000000
fast: false
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reversible: true
reactant: MODEL1310110012#
name: RE3568

metaR CYANtm
kinetic law: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
reactant: MODEL1310110012#
name: Cyanide transport via diffusion (mitochondrial)
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false

metaR r1852
modifier: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
reversible: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110012#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110012#_1a283d03_aa55_48dd_bb7f_2a06b7e259dd
type: Species
is: SBO:0000252
is: P11182
initial concentration: NaN
name: DBT
initial amount: NaN
is encoded by: hsa:1629
has only substance units: false
constant: false
boundary condition: true

metaR CRNCARtp
type: Reaction
reactant: MODEL1310110012#
reversible: false
product: MODEL1310110012#
name: carnitine-acetylcarnitine carrier, peroxisomal
kinetic law: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110012#_18e1112c_216f_4b49_8388_5c4de7b9d6b1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: O75251
name: NDUFS7
constant: false
is encoded by: hsa:374291
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_195444a6_a1f8_41ca_ae51_ad32016082c1
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: OGDH
is encoded by: hsa:4967
is: Q02218

metaM amp e
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:456215
boundary condition: false
initial amount: NaN
is: C00020
is: HMDB00045
constant: false
name: AMP
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020

metaR B3GNT33g
is described by: ECO:0000269
reactant: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
is: SBO:0000176
modifier: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_a8502462_036b_4c8b_9a83_fa206f70e4c9
is encoded by: hsa:23428
constant: false
is: SBO:0000252
boundary condition: true
type: Species
name: SLC7A8
initial concentration: NaN
has only substance units: false
is: Q9UHI5
initial amount: NaN

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaR PTE3x
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
fast: false
type: Reaction
modifier: MODEL1310110012#
reversible: false
name: peroxisomal acyl-CoA thioesterase
reactant: MODEL1310110012#
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176
is described by: ECO:0000000

metaM 3hodcoa c
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
name: (S)-3-Hydroxyoctadecanoyl-CoA
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB13336

metaR PAPStg
product: MODEL1310110012#
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
fast: false
is: SBO:0000185
is described by: ECO:0000269
name: 3'-Phosphoadenylyl sufate Golgi transport
reversible: true

metaR XOL7AONEtr
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000000
reversible: true
name: lipid, flip-flop intracellular transport
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110012#

metaR GLCNACASE2ly
type: Reaction
name: alpha-N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reversible: false
reactant: MODEL1310110012#
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.50
kinetic law: MODEL1310110012#
is: SBO:0000176
fast: false

metaR S6T16g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110012#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
is described by: ECO:0000000
reactant: MODEL1310110012#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110012#
reversible: false
kinetic law: MODEL1310110012#

metaR SERGLYexR
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
type: Reaction
is: SBO:0000185
fast: false
modifier: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000304
product: MODEL1310110012#
name: L-Serine/Glycine reversible exchange

metaM tag hs c
type: Species
is: CHEBI:17855
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
has only substance units: false
name: triglyceride
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_c4ca9278_ef16_4cc7_bfb6_0f8272e5af16
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:55825
is: SBO:0000252
has only substance units: false
name: PECR
type: Species
is: Q9BY49
constant: false

metaM tymsf e
name: Tyramine O-sulfate
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB06409
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_980321c5_78fc_4a5d_b7ee_4090c7cd000b
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:23428
is: SBO:0000252
is: Q86U05
boundary condition: true
has only substance units: false
name: SLC7A8
type: Species

metaM HC01408 m
boundary condition: false
type: Species
initial amount: NaN
name: 3-Oxohexanoyl-CoA
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:27648
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_fbc34e3f_e6ca_4079_893b_b2da0b19e08d
initial concentration: NaN
name: GPAM
is: Q8N1G6
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:57678
constant: false
boundary condition: true
has only substance units: false

metaR RE1531M
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110012#
product: MODEL1310110012#
is: SBO:0000176
modifier: MODEL1310110012#
reversible: true
name: RE1531
kinetic law: MODEL1310110012#

metaM lgnc e
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
is: CHEBI:31014
constant: false
is: HMDB02003
type: Species
has only substance units: false
initial concentration: 1.0
name: lignocerate
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaM vitd3 c
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00876
is: CHEBI:28940
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
name: calciol

metaR ACNAMtn
is described by: ECO:0000000
reversible: false
name: N-acetylneuraminate nuclear import
kinetic law: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110012#
is: SBO:0000185
type: Reaction
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_213c2ae6_9088_47ca_a25f_dec5da4b3757
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:2181
is: O95573
has only substance units: false
name: ACSL3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_d042d58e_b567_4cba_8772_acf08e676826
is: SBO:0000252
name: _AI972237_1_c
initial amount: NaN
is encoded by: hsa:AI972237
constant: false
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_71b6d6cb_9370_4a4c_aef6_153acb3a4eac
is: SBO:0000252
initial amount: NaN
is: Q6FHI7
is encoded by: hsa:762
name: CA4
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false

metaM 3hdeccoa m
boundary condition: false
name: 3-hydroxyhexadecenoylcoa
is: HMDB02288
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_b4770777_48e2_457f_84cb_a9abf9c64c8e
is encoded by: hsa:4704
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is: Q16795
name: NDUFA9
boundary condition: true
initial concentration: NaN

metaR 3MOBte
name: Transport of 3-methyl-2-oxobutanoate
reversible: true
fast: false
kinetic law: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR LEULEULAPc
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Leucylleucine in the small intestine for cellular uptake
type: Reaction

metaR ADCim
name: Acetoacetate decarboxylation (irreversible), mitochondrial
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_36c07b7c_7a79_4be1_8991_ed6ac0cdcccd
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:284111
is: Q86YT5
boundary condition: true
type: Species
initial amount: NaN
name: SLC13A5
has only substance units: false
constant: false

metaM amp c
initial concentration: 1.0
type: Species
is: CHEBI:3322
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2
initial amount: NaN
name: AMP
is: HMDB00045
has only substance units: false
constant: false
is: C00020

metaR GLNS
is: SBO:0000176
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110012#
reversible: false
product: MODEL1310110012#
type: Reaction
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/4.1.1.15
name: glutamine synthetase
reactant: MODEL1310110012#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110012#_38a47593_7cc1_47ff_8b8d_a9c6991a7b40
is encoded by: hsa:126129
is: Q8TCG5
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
name: CPT1C
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110012#_358b5766_b644_484e_ba7b_03ef6486af7b
name: PDE6C
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5146
type: Species
constant: false
is: P51160

metaM ps hs m
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
type: Species
has only substance units: false
constant: false
name: ps_hs[m]
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:18303
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_26317eaa_4581_46bc_ad45_af36ca3c29b2
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
constant: false
is encoded by: hsa:517
has part: Q06055
initial concentration: NaN
is: SBO:0000297

metaM dlnlcg e
is: CHEBI:53486
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: HMDB02925
name: dihomo-gamma-linolenic acid (n-6)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_73f08705_1bb1_4d89_ab16_abe4e8cfb093
boundary condition: true
name: OCRL
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is: Q01968
constant: false
is encoded by: hsa:4952
initial concentration: NaN

metaR r2521
reversible: true
name: Utilized transport
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
reactant: MODEL1310110012#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110012#
product: MODEL1310110012#

metaR S6T18g
fast: false
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
product: MODEL1310110012#
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.2.21
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.8.2.17
reversible: false

metaR r1706
kinetic law: MODEL1310110012#
fast: false
modifier: MODEL1310110012#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110012#
name: Y+LAT2 Utilized transport
type: Reaction
is described by: ECO:0000000
product: MODEL1310110012#
reversible: false

metaR 34DHOXPEGOX
type: Reaction
product: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: true
name: 3,4-Dihydroxyphenylethyleneglycol:NAD+ oxidoreductase
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.1.99.24
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (130.1) or (127.1) or (125.1 and 124.1) or (131.1) or (126.1 and 124.1) or (128.1) or (137872.1) or (125.1 and 126.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.1.1.1 Confidence Level: 4 AUTHORS: PMID:3466164 NOTES:SAB
fast: false
is: SBO:0000176

metaR RE3245C
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
is: SBO:0000176
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
reversible: true
name: RE3245
fast: false
type: Reaction

metaR RE1807M
name: RE1807
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000000
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reactant: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_9a34ae94_6c66_4c3f_9b3f_6d45ba93e4cb
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:81539
type: Species
name: SLC38A1
constant: false
is: Q9H2H9
initial concentration: NaN

metaM 5dpmev c
name: (R)-5-Diphosphomevalonate
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB01090
is: SBO:0000247
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1
type: Species
initial amount: NaN

metaM tymsf c
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB06409
constant: false
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
boundary condition: false
name: Tyramine O-sulfate
initial concentration: 1.0
has only substance units: false

metaM creat c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
name: creatine
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00064
is: CHEBI:16919
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300

http://identifiers.org/biomodels.db/MODEL1310110012#_8b9e30da_a768_4b3a_9c3a_423988f55368
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: CDO1
is: Q16878
initial amount: NaN
has only substance units: false
is encoded by: hsa:1036
constant: false

metaM lgnc c
is: SBO:0000247
initial amount: NaN
is: CHEBI:31014
constant: false
is: HMDB02003
has only substance units: false
type: Species
name: lignocerate
initial concentration: 1.0
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110012#_757f5f14_a087_487f_bae0_13636c1926fc
name: NT5C1B
is: SBO:0000252
type: Species
is encoded by: hsa:93034
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: B3KUK6
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_6e580f67_1789_4576_a98c_eafbe2f182b1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
name: NDUFB10
type: Species
boundary condition: true
initial amount: NaN
is: A8K761
is encoded by: hsa:4716

metaR CORE4GTg
reversible: false
kinetic law: MODEL1310110012#
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
is described by: ECO:0000000
fast: false
product: MODEL1310110012#
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.4.1.102
type: Reaction
is: SBO:0000176
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD

metaR FAOXC22C20x
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22-->C20)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_f2365502_9fed_41bc_8546_7aaf6124eb86
is encoded by: hsa:279
type: Species
initial concentration: NaN
constant: false
has only substance units: false
name: AMY2A
is: SBO:0000252
is: P04746
initial amount: NaN
boundary condition: true

metaM dcdp m
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: CHEBI:58593
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
is: HMDB01245
has only substance units: false
is: SBO:0000247
name: dCDP(3-)

http://identifiers.org/biomodels.db/MODEL1310110012#_cbcf2b54_5552_4e7a_a9d6_eca060361c40
has only substance units: false
is encoded by: hsa:219
initial amount: NaN
type: Species
is: P30837
name: ALDH1B1
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110012#_569300c1_4a5f_41e8_a6e9_12224ccf64bf
initial amount: NaN
boundary condition: true
name: MGAT1
initial concentration: NaN
is: P26572
is encoded by: hsa:4245
is: SBO:0000252
type: Species
has only substance units: false
constant: false

metaR LAPCOAl
product: MODEL1310110012#
is: SBO:0000176
name: lysosomal acid phosphorylase (CoA)
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/3.1.3.2
reactant: MODEL1310110012#
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (53.1) SUBSYSTEM: CoA catabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:11923312,PMID:11994049 NOTES:IT. human enzymes overexpressed on E.coli, Pig Liver
reversible: false

metaM sph1p c
is: HMDB01383
constant: false
initial amount: NaN
is: CHEBI:57939
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
has only substance units: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
type: Species
boundary condition: false

metaR SO4t4 2
reactant: MODEL1310110012#
modifier: MODEL1310110012#
name: sulfate transport via sodium symport
is: SBO:0000185
kinetic law: MODEL1310110012#
fast: false
is described by: ECO:0000269
product: MODEL1310110012#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD

metaM acetol c
type: Species
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
initial amount: NaN
constant: false
name: hydroxyacetone
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:27957
is: HMDB06961
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110012#_a57961fb_fe34_4ac7_b771_de288d53d4a0
boundary condition: true
is: Q9HCC0
has only substance units: false
initial concentration: NaN
name: MCCC2
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:64087

metaR DDECE1CRNe
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of dodecenoyl carnitine into extra cellular space
type: Reaction

metaM galgluside hs c
is: SBO:0000247
boundary condition: false
name: galactosyl glucosyl ceramide
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
is: HMDB06535
initial concentration: 1.0
constant: false

metaM dlnlcg c
constant: false
is: HMDB02925
boundary condition: false
is: CHEBI:53486
initial concentration: 1.0
has only substance units: false
name: dihomo-gamma-linolenic acid (n-6)
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
initial amount: NaN
is: SBO:0000247
type: Species

metaM ethamp c
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00224
name: ethamp[c]
is: CHEBI:58190
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346

http://identifiers.org/biomodels.db/MODEL1310110012#_f6c8488e_5a76_42d7_a82d_622784105630
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
type: Species
name: PLCG1
is: P19174
is: SBO:0000252
is encoded by: hsa:5335
has only substance units: false

metaM bilglcur e
is: SBO:0000247
is: CHEBI:57767
type: Species
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial amount: NaN
constant: false
name: mono(glucosyluronic acid)bilirubin(2-)
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR RE0383C
product: MODEL1310110012#
is described by: ECO:0000000
kinetic law: MODEL1310110012#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
name: RE0383
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.1.1.2
type: Reaction
reversible: true
modifier: MODEL1310110012#

metaM pyr c
boundary condition: false
initial concentration: 1.0
is: HMDB00243
type: Species
initial amount: NaN
name: pyruvate
notes: FORMULA: C3H3O3 CHARGE: -1
is: CHEBI:15361
is: C00022
has only substance units: false
is: http://identifiers.org/pubchem.compound/3324
is: SBO:0000247
constant: false

metaR FAOXC141C141OHm
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C14:1OH)m
type: Reaction

metaM succoa m
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:57292
constant: false
is: HMDB01022
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
type: Species
name: Succinyl-CoA

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_0ef2d48d_b4b4_4121_a543_4968c89eaf6c
initial concentration: NaN
is encoded by: hsa:AA278423
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
name: _AA278423_1_m

metaR r0311
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110012#
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/2.3.1.9
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
is: SBO:0000176

metaR S6T5g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110012#
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110012#
is: SBO:0000176
kinetic law: MODEL1310110012#
modifier: MODEL1310110012#

metaR EX crvnc LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC22:6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_2b6d63d6_0a38_485d_aeba_9600a24b80b1
initial concentration: NaN
name: PLCD1
type: Species
boundary condition: true
is: P51178
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5333
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_daadaeaf_2723_45a1_884b_73e538028b5f
has only substance units: false
initial concentration: NaN
boundary condition: true
name: PLCD3
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is: Q8N3E9
is encoded by: hsa:113026

metaR r2525
fast: false
product: MODEL1310110012#
type: Reaction
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110012#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

http://identifiers.org/biomodels.db/MODEL1310110012#_7008588f_cfd6_479a_b18c_74142f224beb
name: ACOT8
is: O14734
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10005
type: Species

metaR DASCBR
type: Reaction
modifier: MODEL1310110012#
reversible: false
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
product: MODEL1310110012#
kinetic law: MODEL1310110012#
fast: false
name: dehydroascorbate reductase
is: SBO:0000176
reactant: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.8.4.1
is described by: ECO:0000269

metaM pmtcoa r
initial amount: NaN
is: HMDB01338
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: SBO:0000247
name: Palmitoyl-CoA (n-C16:0CoA)
is: C00154
is: CHEBI:3454
constant: false

metaM ca2 c
is: CHEBI:29108
initial amount: NaN
boundary condition: false
name: calcium(2+)
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: HMDB00464
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species

metaM e4p c
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:16897
is: HMDB01321
is: C00279
name: D-Erythrose 4-phosphate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_20555ebb_039d_4c1a_b47f_4965c33257ef
type: Species
name: BCAT2
has only substance units: false
is: O15382
initial concentration: NaN
boundary condition: true
is encoded by: hsa:587
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110012#_deebb889_d348_420b_9b3f_4ef6588f7d6f
name: SLC40A1
type: Species
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:30061
initial amount: NaN
is: Q9NP59
is: SBO:0000252
initial concentration: NaN

metaM ethamp r
has only substance units: false
name: O-phosphonatoethanaminium(1-)
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: HMDB00224
is: CHEBI:58190

metaR r0755
reversible: true
modifier: MODEL1310110012#
product: MODEL1310110012#
type: Reaction
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110012#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
fast: false
is described by: ECO:0000000

metaR SERtN1
reversible: true
reactant: MODEL1310110012#
fast: false
name: Serine transport (Na, H coupled)
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
type: Reaction
is: SBO:0000185
product: MODEL1310110012#
modifier: MODEL1310110012#
is described by: ECO:0000269

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaM ksi deg16 l
notes: FORMULA: C160H258N11O137S7 CHARGE: -7
type: Species
initial concentration: 1.0
is: HMDB00812
name: keratan sulfate I, degradation product 16
has only substance units: false
is: CHEBI:16953
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR O2tm
fast: false
reversible: true
reactant: MODEL1310110012#
is: SBO:0000185
kinetic law: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
name: O2 transport (diffusion)

metaM clpndcoa x
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
is: C16166
is: http://identifiers.org/pubchem.compound/47205476
boundary condition: false
initial amount: NaN
name: clupanodonyl CoA
has only substance units: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
is: HMDB06267

metaR B3GNT11g
notes: GENE_ASSOCIATION: (10678.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
modifier: MODEL1310110012#
product: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: false
is: SBO:0000176
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
reactant: MODEL1310110012#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
fast: false

metaM but m
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: HMDB00039
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:17968
name: butyrate
has only substance units: false

metaR HDECAACBP
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecanoylcoa from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_5b64ed73_9ae9_4c6a_8b7c_2ef94d94b5fc
name: CHST3
is: Q7LGC8
is: SBO:0000252
is encoded by: hsa:9469
has only substance units: false
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_1a0a7c52_828c_459e_91ba_8dc03bf660de
has only substance units: false
constant: false
is encoded by: hsa:H53099
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
name: _H53099_1_m
boundary condition: true

metaR r0310
type: Reaction
is described by: ECO:0000000
product: MODEL1310110012#
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
reversible: false
reactant: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
is: SBO:0000176

metaR r2526
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110012#
reversible: true
kinetic law: MODEL1310110012#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
type: Reaction
reactant: MODEL1310110012#

metaR r1008
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
kinetic law: MODEL1310110012#
fast: false
is described by: ECO:0000000
name: Facilitated diffusion
is: SBO:0000185
product: MODEL1310110012#
reactant: MODEL1310110012#
reversible: false

metaM leuktrC4 c
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:57973
name: leukotriene C4(2-)
is: SBO:0000247
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
type: Species
constant: false
is: HMDB01198
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_c6ebb1ee_ced9_41d6_b41b_6d2ef65fb93d
is: B4DDW0
constant: false
has only substance units: false
initial concentration: NaN
name: RDH11
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:51109

metaR FAOXC226C225m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

metaR FACOAL226
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
type: Reaction
is: SBO:0000176
reversible: true
fast: false
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_5ba30ab7_3197_43dc_9012_6c2a2f44ea37
constant: false
boundary condition: true
is encoded by: hsa:39
initial concentration: NaN
is: Q9BWD1
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ACAT2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_9ce7eb7f_1b1b_4615_81f9_3a37713723bc
is: Q9UEF7
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:9365
name: KL
is: SBO:0000252

metaM C02470 e
is: SBO:0000247
initial concentration: 1.0
constant: false
is: C02470
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
name: Xanthurenic acid
is: http://identifiers.org/pubchem.compound/5485
is: HMDB00881

metaR COt
product: MODEL1310110012#
reversible: true
kinetic law: MODEL1310110012#
name: CO transporter via diffusion
is: SBO:0000185
type: Reaction
reactant: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
is described by: ECO:0000000

metaR r0963
reactant: MODEL1310110012#
reversible: false
fast: false
type: Reaction
name: Facilitated diffusion
product: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110012#

metaM dheas e
initial concentration: 1.0
type: Species
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
initial amount: NaN
boundary condition: false
is: HMDB01032
is: CHEBI:57905
has only substance units: false
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
is: SBO:0000247
constant: false

metaM met L c
type: Species
name: L-methionine
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16643
is: HMDB00696
initial concentration: 1.0
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
boundary condition: false

metaR O2tn
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: O2 nuclear transport
reactant: MODEL1310110012#
is: SBO:0000185
kinetic law: MODEL1310110012#
reversible: true
product: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_7e107602_98d7_4e61_babe_3d67da823d5d
boundary condition: true
is encoded by: hsa:2352
initial concentration: NaN
type: Species
has only substance units: false
is: Q05C14
constant: false
initial amount: NaN
is: SBO:0000252
name: FOLR3

metaR FOLt2
is described by: ECO:0000269
name: folate transport via anion exchange
notes: GENE_ASSOCIATION: (6573.1) or (6573.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:14770311 NOTES:IT
product: MODEL1310110012#
reactant: MODEL1310110012#
kinetic law: MODEL1310110012#
reversible: true
modifier: MODEL1310110012#
fast: false
is: SBO:0000185
type: Reaction

metaR S23T3g
reactant: MODEL1310110012#
is described by: ECO:0000000
product: MODEL1310110012#
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
type: Reaction
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
fast: false
modifier: MODEL1310110012#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.6

metaM decdicoa c
type: Species
initial amount: NaN
has only substance units: false
name: decadienoylcoa
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01168
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
constant: false

metaR EX dag hs LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for diglyceride
type: Reaction

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaR EX estradiol LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: estradiol exchange
type: Reaction

metaM HC02179 c
type: Species
boundary condition: false
is: CHEBI:34306
name: 20-hydroxy-arachidonate
constant: false
is: SBO:0000247
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR FAOXC164m
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaR ASPNATm
kinetic law: MODEL1310110012#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.3.1.17 Confidence Level: 4 AUTHORS: PMID:11279290 NOTES:MM
type: Reaction
name: aspartate N-acetyltransferase, mitochondrial
product: MODEL1310110012#
reactant: MODEL1310110012#

metaR r0962
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
type: Reaction
reversible: false
is described by: ECO:0000000
name: Facilitated diffusion
fast: false
reactant: MODEL1310110012#
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is: SBO:0000185

metaR BCRNe
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy butyryl carnitine into extra cellular space
type: Reaction

metaM fn2m2masn g
type: Species
initial concentration: 1.0
is: SBO:0000247
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
boundary condition: false
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:32984

http://identifiers.org/biomodels.db/MODEL1310110012#_629a53b1_9081_4a81_9fb3_a30a9f92cde1
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:5152
initial amount: NaN
name: PDE9A
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_7405c684_bb8b_4fdf_aa51_c26c66d3cf2a
is: Q9BX95
is: SBO:0000252
name: SGPP1
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:81537

http://identifiers.org/biomodels.db/MODEL1310110012#_c37eb1ae_df4a_4edf_8f1d_25102a52fc5b
initial concentration: NaN
is: P37268
boundary condition: true
is encoded by: hsa:2222
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: FDFT1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_2e7f1113_d859_4233_90d4_1fe432c4c00c
has only substance units: false
name: FBP2
is: O00757
boundary condition: true
is encoded by: hsa:8789
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN

metaM thp2c c
is: HMDB12130
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
has only substance units: false
name: 1-piperideine-6-carboxylate
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:16987
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_ea9c1a12_b468_4af6_80b5_fc4b96e46f6b
boundary condition: true
type: Species
initial concentration: NaN
is: P26439
is: SBO:0000252
has only substance units: false
name: HSD3B2
is encoded by: hsa:3284
constant: false
initial amount: NaN

metaM cmpacna c
has only substance units: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
name: CMP-N-acetyl-beta-neuraminate(2-)
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:57812
is: HMDB01176

http://identifiers.org/biomodels.db/MODEL1310110012#_c28e0dc1_25de_47db_aff7_9260a020c0e5
name: CA12
is encoded by: hsa:771
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000252

metaR FACOAL224
modifier: MODEL1310110012#
reactant: MODEL1310110012#
reversible: true
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
product: MODEL1310110012#
kinetic law: MODEL1310110012#
is described by: ECO:0000000

metaM leuktrC4 e
initial concentration: 1.0
name: leukotriene C4(2-)
constant: false
is: HMDB01198
is: CHEBI:57973
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110012#_c97d7464_0c10_431c_ba51_fb3d025e8796
name: UGDH
initial concentration: NaN
boundary condition: true
is: O60701
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:7358
initial amount: NaN
constant: false

metaM met L e
initial amount: NaN
is: CHEBI:16643
name: L-methionine
type: Species
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
initial concentration: 1.0
is: HMDB00696
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_b4a09ca9_e29b_4e24_90af_129f868f945c
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
name: NPR2
constant: false
is encoded by: hsa:4882
type: Species
is: SBO:0000252
is: P20594

metaR r0758
reversible: true
reactant: MODEL1310110012#
type: Reaction
modifier: MODEL1310110012#
name: 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase Tryptophan metabolism EC:1.2.1.3
is: SBO:0000176
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:8155713,PMID:8605195 NOTES:
kinetic law: MODEL1310110012#
is described by: ECO:0000000
fast: false

metaM C02470 c
is: HMDB00881
is: SBO:0000247
is: C02470
constant: false
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
boundary condition: false
name: Xanthurenic acid
is: http://identifiers.org/pubchem.compound/5485
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110012#_117f2eae_24d8_44af_bdcb_c4232821cf5c
is encoded by: hsa:1593
is: SBO:0000252
boundary condition: true
is: Q02318
type: Species
name: CYP27A1
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false

metaR O2tp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110012#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110012#
is: SBO:0000185
name: O2 transport, peroxisomal
kinetic law: MODEL1310110012#
reversible: true

metaM vitd3 e
is: HMDB00876
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:28940
initial concentration: 1.0
type: Species
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
name: calciol
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_25a8da60_d972_4648_88f3_f7de95927410
type: Species
initial amount: NaN
initial concentration: NaN
name: NANS
boundary condition: true
is: SBO:0000252
is: Q9NR45
is encoded by: hsa:54187
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110012#_c5949d2d_efaf_449c_86e1_0b70fa72b20e
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: Q8NFF5
boundary condition: true
name: FLAD1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:80308

http://identifiers.org/biomodels.db/MODEL1310110012#_3f01bc08_39b8_48aa_8c18_53c2d39bac5b
is encoded by: hsa:5728
name: PTEN
is: SBO:0000252
is: F6KD01
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaM hestratriol c
type: Species
boundary condition: false
name: 4,17 dihydroxy estradiol
constant: false
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB05896

metaM CE4792 m
has only substance units: false
is: SBO:0000247
is: CHEBI:57923
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: 3-oxo-cis-8-tetradecenoyl-CoA
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792

metaR FACOAL181i
reactant: MODEL1310110012#
type: Reaction
reversible: false
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
product: MODEL1310110012#
name: C181 fatty acid activation
modifier: MODEL1310110012#
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
kinetic law: MODEL1310110012#

http://identifiers.org/biomodels.db/MODEL1310110012#_f7a6df49_c101_404d_bad6_e44aa6ce62f9
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:221823
initial amount: NaN
name: PRPS1L1
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110012#_f93cf1ca_e920_4de4_b9dd_d14d7c3af47b
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: _AI971036_1_m
is: SBO:0000252
constant: false
is encoded by: hsa:AI971036

http://identifiers.org/biomodels.db/MODEL1310110012#_31c51835_36df_4e36_9deb_e1ce7c0bf60e
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:6483
initial concentration: NaN
initial amount: NaN
is: Q16842
type: Species
name: ST3GAL2

http://identifiers.org/biomodels.db/MODEL1310110012#_17698b4e_c06f_4f58_8119_2c069369056d
name: DGKH
is encoded by: hsa:160851
is: Q86XP1
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN

metaM crvnc e
notes: FORMULA: C22H31O2 CHARGE: -1
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB02183
type: Species
is: SBO:0000247
name: cervonic acid, C22:6 n-3
is: CHEBI:36005
constant: false
initial amount: NaN

metaR SIAT4Bg
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.4
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
fast: false
is described by: ECO:0000269
modifier: MODEL1310110012#
reversible: false
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
product: MODEL1310110012#

metaM HC02179 e
is: SBO:0000247
is: CHEBI:34306
initial concentration: 1.0
name: 20-hydroxy-arachidonate
has only substance units: false
type: Species
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
constant: false
boundary condition: false
initial amount: NaN

metaR NRPPHRSULT
is: SBO:0000176
fast: false
modifier: MODEL1310110012#
is described by: ECO:0000269
reversible: false
name: Norepinephrine Sulfotransferase
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.1
product: MODEL1310110012#
kinetic law: MODEL1310110012#

metaM ha pre1 e
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
type: Species
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
initial concentration: 1.0
is: CHEBI:16126
has only substance units: false
name: hyaluronan biosynthesis, precursor 1

metaR NORANMT
reactant: MODEL1310110012#
is: SBO:0000176
fast: false
name: noradrenaline N-methyltransferase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.1.28
reversible: false
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
type: Reaction
product: MODEL1310110012#
notes: GENE_ASSOCIATION: (5409.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.1.1.28 Confidence Level: 4 AUTHORS: NOTES:SAB

metaR FBA2
reactant: MODEL1310110012#
fast: false
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000304
product: MODEL1310110012#
is version of: http://identifiers.org/ec-code/4.1.2.13
is: SBO:0000176
modifier: MODEL1310110012#
kinetic law: MODEL1310110012#
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110012#_60948b22_6ef2_4926_abf6_340d016f6bf8
boundary condition: true
is: P24310
is encoded by: hsa:1346
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false
name: COX7A1
initial amount: NaN

metaR FRDPtcr
is described by: ECO:0000134
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
reversible: true
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
is: SBO:0000185
product: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
type: Reaction

metaM fuc1p L c
is: HMDB01265
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: L-Fucose 1-phosphate
initial amount: NaN
constant: false
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
is: CHEBI:28319
has only substance units: false
type: Species

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaR FUT910g
reactant: MODEL1310110012#
reversible: false
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
product: MODEL1310110012#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.152
modifier: MODEL1310110012#
name: Alpha-(1,3)-fucosyltransferase
kinetic law: MODEL1310110012#
type: Reaction
is described by: ECO:0000269

metaR DMHPTCRNt
fast: false
name: 2,6 dimethylheptanoyl crn transport
product: MODEL1310110012#
is: SBO:0000185
reactant: MODEL1310110012#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES:dmhptcoa is 'special' because its biochemical fat isn't known NJ
reversible: true

metaM q10 c
boundary condition: false
name: ubiquinone-10
type: Species
is: HMDB01072
is: CHEBI:46245
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
initial amount: NaN

metaM 34hpl m
boundary condition: false
is: CHEBI:36659
constant: false
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8,10-11H,5H2,(H,12,13)/p-1
initial concentration: 1.0
has only substance units: false
name: 3-(4-hydroxyphenyl)lactate
initial amount: NaN
type: Species
is: HMDB00755
is: SBO:0000247

metaR GALASE19ly
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110012#
fast: false
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110012#_7daf2ae7_2bc8_4256_a4db_81d996dd9c6b
type: Species
boundary condition: true
name: ATP5E
is encoded by: hsa:514
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P56381
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_6dceb6c8_3774_476a_964e_9c8c7bc3b695
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:1120
constant: false
boundary condition: true
type: Species
is: Q9Y259
name: CHKB
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_4ae11e6e_7bc2_45c7_afa0_2f5165fa3e8e
is: B4DER4
type: Species
initial concentration: NaN
has only substance units: false
name: PIK3CB
is: SBO:0000252
is encoded by: hsa:5291
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110012#_9c92781a_fe7a_41ea_b90a_ffe847418660
is: Q9NUB1
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:84532
name: ACSS1

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaM ca2 e
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
name: calcium(2+)
is: HMDB00464
boundary condition: false
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:29108

http://identifiers.org/biomodels.db/MODEL1310110012#_2b43ccf1_95e6_494a_94ee_227c5410f0fc
initial concentration: NaN
constant: false
name: _U37519_1_c
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:U37519

metaR EX 3hexdcrn
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecanoyl carnitine
type: Reaction

metaM hestratriol e
has only substance units: false
type: Species
constant: false
boundary condition: false
initial amount: NaN
name: 4,17 dihydroxy estradiol
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
initial concentration: 1.0
is: SBO:0000247
is: HMDB05896

http://identifiers.org/biomodels.db/MODEL1310110012#_129ef5d0_482c_4525_95cb_7d05411405ee
boundary condition: true
is: SBO:0000252
constant: false
name: IK
has only substance units: false
type: Species
initial amount: NaN
is: Q13123
is encoded by: hsa:3550
initial concentration: NaN

metaM crvnc c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB02183
name: cervonic acid, C22:6 n-3
type: Species
is: SBO:0000247
is: CHEBI:36005
notes: FORMULA: C22H31O2 CHARGE: -1
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_3c3c2427_607d_4845_8175_3eca267a8ec3
initial amount: NaN
name: PLCH2
is: O75038
is encoded by: hsa:9651
type: Species
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110012#_56506509_af14_4711_a283_e21e7cf6985c
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:26503
initial amount: NaN
constant: false
name: SLC17A5
is: SBO:0000252
is: Q9NRA2
initial concentration: NaN

metaM HC01231 m
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
is: SBO:0000247
name: N-[(R)-pantothenoyl]-L-cysteinate
type: Species
constant: false
is: CHEBI:58480
has only substance units: false
initial amount: NaN

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_e6e56f95_2ecf_4162_802f_d5bf9fc70dd7
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is: Q15849
is encoded by: hsa:8170
name: SLC14A2

metaM tststerone r
boundary condition: false
name: testosterone
type: Species
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: SBO:0000247
is: CHEBI:17347
is: HMDB00234
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110012#_b27a1651_9baa_4ad4_bdb2_8af3b960470d
boundary condition: true
name: SLC7A10
initial concentration: NaN
initial amount: NaN
is: Q9NS82
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:56301

metaR ALADGLYexR
type: Reaction
reactant: MODEL1310110012#
name: D-alanine/glycine reversible exchange
is: SBO:0000185
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110012#
product: MODEL1310110012#
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110012#

metaR P4502C19
modifier: MODEL1310110012#
is version of: http://identifiers.org/ec-code/1.14.13.48
name: cytochrome P450 2C19
is: SBO:0000176
product: MODEL1310110012#
reversible: false
reactant: MODEL1310110012#
fast: false
kinetic law: MODEL1310110012#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1557.1) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15579107,PMID:3442670 NOTES:omeprazole 5 methyl hydroxylation assumed to take place on outer membrane - since a xenobiotic NJ

metaM ttdcrn c
type: Species
is: http://identifiers.org/pubchem.compound/3413344
name: tetradecanoyl carnitine
initial concentration: 1.0
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
constant: false
has only substance units: false
is: HMDB05066
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM cmpacna g
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB01176
is: CHEBI:57812
type: Species
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
boundary condition: false
is: SBO:0000247
name: CMP-N-acetyl-beta-neuraminate(2-)
has only substance units: false

metaM dgpi prot hs r
has only substance units: false
is: SBO:0000247
name: deacylated-glycophosphatidylinositol (GPI)-anchored protein
initial concentration: 1.0
initial amount: NaN
is: CHEBI:53486
boundary condition: false
is: HMDB02925
type: Species
constant: false
notes: FORMULA: C39H76N4O37P4FULLRCO2FULLR2CO2X CHARGE: 0

metaM udpg r
type: Species
boundary condition: false
is: HMDB00286
initial concentration: 1.0
is: CHEBI:58367
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029

metaM q10 e
type: Species
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
is: HMDB01072
boundary condition: false
is: CHEBI:46245
name: ubiquinone-10
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110012#
reactant: MODEL1310110012#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110012#_abf3f480_1db0_400d_883a_66329f804e59
type: Species
is: O43181
has only substance units: false
name: NDUFS4
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4724
constant: false