metaM leuktrB4 e
name: leukotriene B4(1-)
type: Species
is: CHEBI:57461
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB01085
boundary condition: false
initial concentration: 1.0

metaR CYTK3
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110011#
is described by: ECO:0000269
fast: false
product: MODEL1310110011#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
type: Reaction
name: cytidylate kinase (CMP)(GTP)
modifier: MODEL1310110011#
reversible: true

metaR RE0958E
is described by: ECO:0000000
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
reversible: true
product: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
name: RE0958

http://identifiers.org/biomodels.db/MODEL1310110011#_6b074c1c_055c_4ba7_8f17_200dca73b6ee
name: GGT7
boundary condition: true
initial concentration: NaN
is: A0PJJ9
constant: false
is encoded by: hsa:2686
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species

metaR RE1573M
is: SBO:0000176
fast: false
is described by: ECO:0000000
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
name: RE1573
type: Reaction
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/5.3.3.8
product: MODEL1310110011#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR CLPNDCOAtx
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
kinetic law: MODEL1310110011#
name: fatty acid intracellular transport
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110011#

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaR CYTK4
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
modifier: MODEL1310110011#
reversible: true
product: MODEL1310110011#
name: cytidylate kinase (dCMP)(GTP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
reactant: MODEL1310110011#
is described by: ECO:0000269
kinetic law: MODEL1310110011#
type: Reaction

metaM HC01231 c
is: CHEBI:58480
constant: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
type: Species
initial amount: NaN
name: N-[(R)-pantothenoyl]-L-cysteinate
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR RE3244R
modifier: MODEL1310110011#
name: RE3244
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000000
reversible: true
fast: false

metaR FAOXC226C225m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

metaR LDH L
name: L-lactate dehydrogenase
kinetic law: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000000
reversible: true
type: Reaction
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
is version of: http://identifiers.org/ec-code/1.1.1.27
is: SBO:0000176

metaR GASNASE2ly
name: glycosylasparaginase, lysosomal
modifier: MODEL1310110011#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.26
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
product: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD

metaR C142OHc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradeca dienoyl carnitine
type: Reaction

metaR H2MTer L
type: Reaction
product: MODEL1310110011#
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
is: SBO:0000176
fast: false
reversible: false
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
name: H2 mannosyltransferase, endoplasmic reticulum
is described by: ECO:0000000

metaR DURAD
is: SBO:0000176
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.1.2
fast: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110011#
name: dihydrouracil dehydrogenase (NADP)
reversible: true
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#

metaR CAt7r
is described by: ECO:0000269
name: calcium / sodium antiporter (1:3), reversible
reversible: true
notes: GENE_ASSOCIATION: (6547.6) or (6547.4) or (6547.2) or (6546.1) or (6547.1) or (6547.5) or (6543.1) or (6547.3) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12406570,PMID:2484986 NOTES:MM
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_dcbc60a2_17d5_42de_90e5_61a011aa4ad0
is encoded by: hsa:55753
is: SBO:0000252
type: Species
boundary condition: true
is: Q9ULD0
constant: false
name: OGDHL
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_161e4690_8c21_4b8e_a278_10e98be504bb
initial amount: NaN
is: A8K0I1
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:160851
boundary condition: true
type: Species
has only substance units: false
name: DGKH

metaM m4masn g
is: C05881
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C46H77N2O35X CHARGE: 0
initial amount: NaN
type: Species
is: SBO:0000247

metaM leuktrB4 c
boundary condition: false
constant: false
is: SBO:0000247
name: leukotriene B4(1-)
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial concentration: 1.0
is: HMDB01085
has only substance units: false
type: Species
is: CHEBI:57461

metaR SARDHm
kinetic law: MODEL1310110011#
product: MODEL1310110011#
fast: false
name: Sarcosine dehydrogenase (m)
type: Reaction
modifier: MODEL1310110011#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
is: SBO:0000176
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.5.99.1

metaR P5CRxm
name: pyrroline-5-carboxylate reductase (m)
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:PRO1x is irreversible in the other direction
is version of: http://identifiers.org/ec-code/1.5.1.2
modifier: MODEL1310110011#
is: SBO:0000176
product: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
reversible: false
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_4a257104_f56b_40af_a585_a0c0c9be1cdb
initial amount: NaN
initial concentration: NaN
is: P42126
name: ECI1
boundary condition: true
constant: false
type: Species
is encoded by: hsa:1632
is: SBO:0000252
has only substance units: false

metaR r2110
modifier: MODEL1310110011#
product: MODEL1310110011#
reversible: true
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
type: Reaction

metaR ACONTm
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110011#
reversible: true
is described by: ECO:0000134
name: Aconitate hydratase
is version of: http://identifiers.org/ec-code/4.2.1.3
product: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical

metaM pnto R e
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:7916
name: (R)-Pantothenate
is: SBO:0000247
is: HMDB00210
boundary condition: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568

metaM frdp x
is: CHEBI:175763
name: farnesyl pyrophosphate(3-)
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00961
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
initial concentration: 1.0
has only substance units: false
type: Species

metaR CO2tp
name: CO2 peroxisomal transport
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#

metaR CYTK2
modifier: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000269
fast: false
type: Reaction
reversible: true
product: MODEL1310110011#
is: SBO:0000176
name: cytidylate kinase (dCMP)
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110011#_c3302b3b_676c_41df_8b10_6f3e5970d971
has only substance units: false
is: SBO:0000252
is encoded by: hsa:115584
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: Q8WWX8
initial amount: NaN
name: SLC5A11

metaR S6T6g
kinetic law: MODEL1310110011#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110011#
is: SBO:0000176
type: Reaction
product: MODEL1310110011#
reversible: false
fast: false

metaR HPDCACRNCPT2
name: heptadecanoate transport into the mitochondria
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
modifier: MODEL1310110011#
reversible: false
fast: false
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_e4be333d_46a3_4e50_ba1f_00e7998e5868
is encoded by: hsa:56301
boundary condition: true
is: SBO:0000252
name: SLC7A10
initial amount: NaN
type: Species
is: Q9NS82
constant: false
initial concentration: NaN
has only substance units: false

metaR CYTK1
reversible: true
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110011#
name: cytidylate kinase (CMP)
type: Reaction
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#

metaR DPHMBDCm
reversible: false
product: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#
is: SBO:0000176
fast: false
reactant: MODEL1310110011#
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate decarboxylation
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212,PMID:7380842 NOTES:enzyme has not been identified yet IT
is described by: ECO:0000000

metaM pre prot r
name: glycophosphatidylinositol (GPI)-anchored protein precursor
initial concentration: 1.0
type: Species
is: CHEBI:16038
notes: FORMULA: XY CHARGE: 0
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false

metaR LNLNCGt
is described by: ECO:0000000
product: MODEL1310110011#
reactant: MODEL1310110011#
name: fatty acid transport via diffusion
kinetic law: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reversible: true
type: Reaction

metaR HPDCACRNCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine fatty-acyl transferase
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (1375.2) or (1375.3) or (1374.1) or (126129.1) or (1375.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
reactant: MODEL1310110011#

metaR CYTK7
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,UTP)
modifier: MODEL1310110011#
is: SBO:0000176
reactant: MODEL1310110011#
is described by: ECO:0000269
product: MODEL1310110011#
reversible: true
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110011#

metaM sbcoa x
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
name: suberylcoa
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN

metaR ASNTHRNaEx
product: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-threonine/L-asparagine Na-dependent exchange (Asn-L in)
reversible: false
modifier: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000269

metaR r0668
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.4.2.19
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110011#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reversible: true

metaR RE2651R
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
kinetic law: MODEL1310110011#
is described by: ECO:0000000
product: MODEL1310110011#
is: SBO:0000176
name: RE2651

http://identifiers.org/biomodels.db/MODEL1310110011#_0a005e8a_484d_4fd0_9326_f0cfd4f65ffc
is encoded by: hsa:2023
initial concentration: NaN
initial amount: NaN
name: ENO1
type: Species
is: E2DRY6
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252

metaR DOLP Lter
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is described by: ECO:0000000
name: dolichol phosphate flippase (liver)
reactant: MODEL1310110011#
is: SBO:0000176

metaM pnto R c
has only substance units: false
initial amount: NaN
constant: false
name: (R)-Pantothenate
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: CHEBI:7916
is: HMDB00210
type: Species
initial concentration: 1.0

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaR CYTK8
fast: false
name: cytidylate kinase (CMP,dATP)
product: MODEL1310110011#
is: SBO:0000176
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
reactant: MODEL1310110011#
is described by: ECO:0000269

metaR EX pectindchac LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectin-deoxycholic acid complex
type: Reaction

metaR r0669
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reversible: false
reactant: MODEL1310110011#

metaM docohepcoa m
name: 2,4,7,10,13,16,19-docosaheptenoylcoa
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB06294
boundary condition: false
initial amount: NaN
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
constant: false

metaM elaid e
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00573
type: Species
name: elaidate
is: CHEBI:30825
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
has only substance units: false

metaR FAEL184
product: MODEL1310110011#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
fast: false
modifier: MODEL1310110011#
reactant: MODEL1310110011#
name: fatty-acyl-CoA elongation (n-C20:4CoA)
kinetic law: MODEL1310110011#
type: Reaction

metaR NDPK5n
reactant: MODEL1310110011#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
is described by: ECO:0000304
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000176
reversible: true
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false

metaM hx2coa m
is: http://identifiers.org/pubchem.compound/11966188
is: HMDB06870
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: SBO:0000247
is: C05998
initial concentration: 1.0
name: trans-Hex-2-enoyl-CoA

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

metaR RE3624M
is described by: ECO:0000000
name: RE3624
reactant: MODEL1310110011#
reversible: false
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110011#
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR r0354
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
type: Reaction
product: MODEL1310110011#
modifier: MODEL1310110011#
is described by: ECO:0000000
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176

metaM glc D c
is: CHEBI:4167
constant: false
is: HMDB00122
boundary condition: false
has only substance units: false
name: D-glucose
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_0445850a_71bf_4826_a36f_10e45e396ad6
type: Species
is: SBO:0000252
is encoded by: hsa:AI601100
initial concentration: NaN
boundary condition: true
name: _AI601100_1_m
initial amount: NaN
has only substance units: false
constant: false

metaM 4mlacac c
type: Species
constant: false
initial amount: NaN
is: HMDB02052
initial concentration: 1.0
is: CHEBI:17105
boundary condition: false
has only substance units: false
name: 4-maleylacetoacetate
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
is: SBO:0000247

metaR r0355
type: Reaction
is: SBO:0000176
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.3
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
product: MODEL1310110011#
is described by: ECO:0000000
reactant: MODEL1310110011#
modifier: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_fe96a07c_bcee_43e9_a8ef_cf1135d61471
is: SBO:0000252
initial concentration: NaN
name: COX6C
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:1345
is: P09669
has only substance units: false
type: Species

metaM malcoa c
name: Malonyl-CoA
is: C00083
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: HMDB01175
is: CHEBI:57384
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN

metaM thp2c x
has only substance units: false
name: 1-piperideine-6-carboxylate
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
constant: false
type: Species
is: HMDB12130
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16987
boundary condition: false
initial amount: NaN

metaR FAEL183
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
reactant: MODEL1310110011#
product: MODEL1310110011#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
name: fatty-acyl-CoA elongation (n-C18:3CoA)
type: Reaction
fast: false

metaR CYTK5
modifier: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110011#
fast: false
product: MODEL1310110011#
is: SBO:0000176
name: cytidylate kinase (dCMP)
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true

metaR RE1530C
name: RE1530
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_f5e440ac_5b84_489f_b466_0bdbe2cefcdd
has only substance units: false
name: RRM2B
is: Q7LG56
boundary condition: true
is encoded by: hsa:50484
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_b006fdad_c9c3_4033_bcee_0f0298d238e9
constant: false
initial amount: NaN
name: HADH
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3033
has only substance units: false
boundary condition: true
type: Species
is: Q16836

metaR sink tetdece1coa LPAREN c RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDECE1COASINK
type: Reaction

metaR r0242
fast: false
kinetic law: MODEL1310110011#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.1
is described by: ECO:0000000
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
reactant: MODEL1310110011#
product: MODEL1310110011#
reversible: true
modifier: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_889195c3_6633_4dca_8608_81d9785837a0
is: Q02318
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:1593
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
name: CYP27A1

metaR EX leugly LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylglycine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_24d3bed4_6beb_499b_8340_fb6d5e06303b
is: SBO:0000252
initial amount: NaN
type: Species
name: DGKH
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: Q86XP1
is encoded by: hsa:160851

metaR CYTK6
reactant: MODEL1310110011#
is described by: ECO:0000269
product: MODEL1310110011#
modifier: MODEL1310110011#
name: cytidylate kinase (CMP,CTP)
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
type: Reaction

metaM elaid c
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
is: HMDB00573
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: elaidate
is: CHEBI:30825

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaR r0931
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reversible: false
reactant: MODEL1310110011#
type: Reaction
name: Transport reaction
fast: false
is: SBO:0000185

metaR EX c81crn
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_76229587_c6ee_4dad_9e2e_586973f32b7c
is encoded by: hsa:23428
has only substance units: false
is: Q9UHI5
initial amount: NaN
initial concentration: NaN
name: SLC7A8
type: Species
is: SBO:0000252
constant: false
boundary condition: true

metaM pail45p hs n
name: phosphatidylinositol 4,5-bisphosphate
initial concentration: 1.0
is: CHEBI:28910
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
boundary condition: false
constant: false

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaM glc D e
is: HMDB00122
name: D-glucose
boundary condition: false
is: CHEBI:4167
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
type: Species
initial concentration: 1.0

metaR CLOXAtex2
modifier: MODEL1310110011#
product: MODEL1310110011#
name: chloride transport via oxalate countertransport (2:1)
is: SBO:0000185
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
reversible: false
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_f8ba1b7f_64fe_4db3_9c20_2317b387d01e
name: _HG2846_HT2983_1_m
constant: false
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:HG2846-HT2983

metaR r0932
name: Transport reaction
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
product: MODEL1310110011#
is described by: ECO:0000000
reactant: MODEL1310110011#

metaR C40CPT1
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

metaM malcoa r
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
name: malonyl-CoA(4-)
is: CHEBI:57384
is: SBO:0000247
constant: false
is: HMDB01175
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_1f501b3c_9fb9_4c65_be91_462291a7f738
has only substance units: false
is: Q4G1C4
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:284273
is: SBO:0000252
name: ZADH2
type: Species
initial concentration: NaN

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR r0245
fast: false
kinetic law: MODEL1310110011#
type: Reaction
is: SBO:0000176
product: MODEL1310110011#
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.3
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
reactant: MODEL1310110011#
is described by: ECO:0000000
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
modifier: MODEL1310110011#

metaR FAOXC163Gm
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

metaM pser L c
is: CHEBI:15811
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
is: HMDB01721
boundary condition: false
name: O-Phospho-L-serine
type: Species
has only substance units: false

metaM gpi sig r
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
type: Species
is: HMDB00224
notes: FORMULA: Y CHARGE: 0
is: CHEBI:58190
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR DDECE1CRNe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of dodecenoyl carnitine into extra cellular space
type: Reaction

metaM HC00664 c
constant: false
is: CHEBI:58695
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-2-6(10)5(9)4(8)3(15-6)1-14-16(11,12)13/h3-5,7-10H,1-2H2,(H2,11,12,13)/p-2/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C01097
name: D-tagatofuranose 6-phosphate(2-)
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_50712ec3_2923_46eb_a0b4_3fe891f470ec
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q96NR8
has only substance units: false
is: SBO:0000252
constant: false
name: RDH12
is encoded by: hsa:145226
type: Species

metaR r0779
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
reversible: false
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#

metaR CYTK9
name: cytidylate kinase (CMP,dCTP)
reactant: MODEL1310110011#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
product: MODEL1310110011#

metaR ADNCYC
is version of: http://identifiers.org/ec-code/4.6.1.1
name: adenylate cyclase
product: MODEL1310110011#
modifier: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
reversible: false
fast: false

metaM 4hbz m
boundary condition: false
name: 4-hydroxybenzoate
initial amount: NaN
is: HMDB00500
is: SBO:0000247
is: CHEBI:17879
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
notes: FORMULA: C7H5O3 CHARGE: -1 INCHI: InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)/p-1

metaR C141ACBP
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradecenoyl coa from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_749b7fe0_f6cb_4a92_a597_6ee4dfb85774
initial concentration: NaN
name: _642502_1_c
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:642502
is: SBO:0000252
constant: false
type: Species

metaR r0246
type: Reaction
is: SBO:0000176
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
is version of: http://identifiers.org/ec-code/1.5.1.3
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#
modifier: MODEL1310110011#
reversible: false
reactant: MODEL1310110011#

metaM sebcoa x
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
type: Species
name: sebacoylcoa
initial amount: NaN

metaM dectricoa m
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
name: 2,4,7-decatrienoylcoa
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_31dee04c_c3b2_4f56_9002_caa87597bd57
is: Q99944
constant: false
has only substance units: false
is encoded by: hsa:80864
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: EGFL8

metaR FAOXC101m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_179cd29d_e638_4b3b_9365_6ebf4f78153b
constant: false
is encoded by: hsa:8801
boundary condition: true
type: Species
initial concentration: NaN
is: Q96I99
name: SUCLG2
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR GAMt1r
reactant: MODEL1310110011#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
is: SBO:0000185
name: glucosamine transport (uniport)
fast: false
reversible: true
product: MODEL1310110011#
modifier: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_a9c1d2fc_3a9a_4286_a928_6928934b656f
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:W87865
is: SBO:0000252
initial amount: NaN
type: Species
name: _W87865_1_c
initial concentration: NaN

metaM ksi pre15 g
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 15
has only substance units: false
constant: false
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
type: Species
initial concentration: 1.0
is: HMDB00175
is: C00130

metaR HSD3A1r
is version of: http://identifiers.org/ec-code/1.1.1.225
type: Reaction
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
fast: false
is: SBO:0000176
kinetic law: MODEL1310110011#
product: MODEL1310110011#
modifier: MODEL1310110011#
reversible: true
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is described by: ECO:0000269

metaM Asn X Ser Thr r
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:28938
boundary condition: false
name: protein-linked asparagine residue (N-glycosylation site)
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: XH CHARGE: 0
is: C01342
is: HMDB00051

http://identifiers.org/biomodels.db/MODEL1310110011#_8eaa60ff_e378_4348_9f87_e00e301f679f
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:4842
name: NOS1
initial amount: NaN
is: B4DG68
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_172b80e4_9011_40c2_9fff_09633718ca15
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:4700
name: NDUFA6
initial concentration: NaN
is: P56556
is: SBO:0000252
type: Species
boundary condition: true

metaM akg x
has only substance units: false
name: 2-oxoglutarate(2-)
is: SBO:0000247
constant: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial amount: NaN
boundary condition: false
is: HMDB00208
is: CHEBI:16810
type: Species
initial concentration: 1.0

metaM ksii core2 pre4 g
is: CHEBI:58053
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: C00130
initial amount: NaN
boundary condition: false
notes: FORMULA: C53H86N4O38X CHARGE: -1
name: keratan sulfate II biosynthesis, precursor 4
is: SBO:0000247
is: HMDB00175

metaR FAOXC225C226m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

metaM frdp r
has only substance units: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: HMDB00961
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
is: C00448
initial amount: NaN
name: Farnesyl diphosphate
is: CHEBI:175763
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_0da35b03_50cf_4202_b3ed_ac05be98458d
type: Species
is encoded by: hsa:6547
initial concentration: NaN
has only substance units: false
is: Q96QG2
boundary condition: true
is: SBO:0000252
name: SLC8A3
initial amount: NaN
constant: false

metaR r2007
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
reversible: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110011#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_0861b122_e767_4d0e_9731_73a8a53c7260
initial concentration: NaN
is: Q8IV97
is encoded by: hsa:8140
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: SLC7A5
has only substance units: false
constant: false
type: Species

metaR FACOAL244 1
reactant: MODEL1310110011#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
type: Reaction
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110011#
product: MODEL1310110011#
modifier: MODEL1310110011#
fast: false

metaM elaidcrn c
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
name: Elaidic carnitine
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB06464

metaM dcdp c
type: Species
initial concentration: 1.0
name: dCDP
is: CHEBI:58593
has only substance units: false
is: HMDB01245
constant: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: C00705

metaR BILDGLCURtr
fast: false
product: MODEL1310110011#
name: glucuronidated compound transport
reversible: true
kinetic law: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
reactant: MODEL1310110011#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_63951c5a_8bd3_4ced_aa50_110a93ef6a9d
name: _AI440329_1_r
is encoded by: hsa:AI440329
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR biomass reaction
kinetic law: MODEL1310110011#
is described by: ECO:0000134
fast: false
reversible: false
is: SBO:0000185
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110011#
name: biomass_reaction

metaM Asn X Ser Thr l
name: protein-linked asparagine residue (N-glycosylation site)
type: Species
initial concentration: 1.0
notes: FORMULA: XH CHARGE: 0
boundary condition: false
is: CHEBI:28938
is: SBO:0000247
constant: false
initial amount: NaN
is: C01342
is: HMDB00051
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_ba150f00_93f6_4f1d_b96b_6fc4ca17fd2c
constant: false
boundary condition: true
is: SBO:0000252
name: VNN3
type: Species
is encoded by: hsa:55350
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR r0249
is version of: http://identifiers.org/ec-code/2.7.7.12
kinetic law: MODEL1310110011#
reversible: true
type: Reaction
is: SBO:0000176
modifier: MODEL1310110011#
fast: false
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
is described by: ECO:0000000
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
reactant: MODEL1310110011#

metaM tststerone e
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
name: testosterone
is: CHEBI:17347
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: HMDB00234
boundary condition: false

metaM xol27oh m
has only substance units: false
is: CHEBI:17703
is: HMDB02103
initial concentration: 1.0
name: 26-hydroxycholesterol
type: Species
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
initial amount: NaN
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_d0e368b8_c4db_46c4_88a3_16bdd90d200b
is encoded by: hsa:48
constant: false
initial concentration: NaN
name: ACO1
is: P21399
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_eba470e9_c291_4032_9b0c_d510451ea857
is: SBO:0000297
is encoded by: hsa:124
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
name: ADH1A:ADH1B
has part: P07327

metaR r0774
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110011#
is: SBO:0000176
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR PTPATe
fast: false
name: PTPATe
reversible: true
kinetic law: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000176
product: MODEL1310110011#
is described by: ECO:0000134
reactant: MODEL1310110011#

metaM CE2421 m
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
name: (3S)-3-hydroxylinoleoyl-CoA
is: SBO:0000247
is: CHEBI:30623
is: HMDB02329
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: false

metaR r0074
is described by: ECO:0000000
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
reversible: true
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is version of: http://identifiers.org/ec-code/6.2.1.1
is: SBO:0000176
type: Reaction
product: MODEL1310110011#
fast: false
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_7d1a5060_a31a_48e9_a2fe_ea19b442be24
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q8WUX1
boundary condition: true
type: Species
is encoded by: hsa:92745
initial concentration: NaN
constant: false
name: SLC38A5

metaR PROD2
kinetic law: MODEL1310110011#
type: Reaction
is: SBO:0000176
reversible: false
fast: false
modifier: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.5.99.8
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR
name: Proline dehydrogenase
reactant: MODEL1310110011#

metaR O2t
name: o2 transport (diffusion)
product: MODEL1310110011#
is: SBO:0000185
reactant: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
fast: false

metaR ADSK
reactant: MODEL1310110011#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.1.25
is: SBO:0000176
reversible: false
fast: false
name: adenylyl-sulfate kinase
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
kinetic law: MODEL1310110011#
product: MODEL1310110011#

metaM tststerone c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17347
name: testosterone
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
boundary condition: false
is: HMDB00234
type: Species
constant: false
has only substance units: false

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_7668bf9a_054e_4c64_bebf_c3a7b9282b0d
name: AK5
is: SBO:0000252
is encoded by: hsa:26289
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false
initial amount: NaN

metaR L LACDcm
name: L-Lactate dehydrogenase, cytosolic/mitochondrial
modifier: MODEL1310110011#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (124637.1) SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:18831974 NOTES:NCD/TDV. This reaction exists in yeast, but no evidence could be found this exists in humans. However, there may be intramitochondrial lactate dehydrogenase and lactate transport into mitochondria
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_8f68ae77_0a48_462b_8d77_490e5e21b90e
is: SBO:0000252
initial amount: NaN
type: Species
is: P19174
is encoded by: hsa:5335
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
name: PLCG1

http://identifiers.org/biomodels.db/MODEL1310110011#_a970ccf8_92a1_4438_be4f_f7d633ba1c83
boundary condition: true
has only substance units: false
constant: false
is: Q10469
is: SBO:0000252
name: MGAT2
type: Species
initial amount: NaN
is encoded by: hsa:4247
initial concentration: NaN

metaM 3octdece1crn e
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: 3-hydroxy-octadecenoyl carnitine
boundary condition: false
initial amount: NaN
is: HMDB13336
notes: FORMULA: C25H47NO5 CHARGE: 0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_498f8713_0dad_4ed5_bad6_0b3cc1cd017e
is: Q02221
is: SBO:0000252
is encoded by: hsa:1339
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: COX6A2
has only substance units: false

metaM 10fthf c
initial amount: NaN
is: C00234
name: 10-Formyltetrahydrofolate
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
is: HMDB00972
has only substance units: false
is: CHEBI:57454
type: Species
constant: false

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaR MGCHrm
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110011#
modifier: MODEL1310110011#
product: MODEL1310110011#
type: Reaction
fast: false
kinetic law: MODEL1310110011#
reversible: true
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
is version of: http://identifiers.org/ec-code/4.2.1.18
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM

metaM gmp e
has only substance units: false
initial concentration: 1.0
is: CHEBI:58115
boundary condition: false
name: GMP(3-)
type: Species
is: HMDB01397
initial amount: NaN
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_cc06801b_8889_4429_b80e_51e6d51bdb9e
type: Species
initial concentration: NaN
constant: false
boundary condition: true
name: ADCY6
initial amount: NaN
is: O43306
is encoded by: hsa:112
has only substance units: false
is: SBO:0000252

metaR r2321
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110011#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110011#
product: MODEL1310110011#

metaR FMNAT
is version of: http://identifiers.org/ec-code/2.7.7.2
name: FMN adenylyltransferase
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
product: MODEL1310110011#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110011#
reversible: false
reactant: MODEL1310110011#
modifier: MODEL1310110011#

metaR r2435
reversible: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110011#
fast: false
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_f4868556_ee8d_4897_a4f7_c080300f8907
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: B2RDU6
is encoded by: hsa:4598
type: Species
name: MVK
boundary condition: true

metaR D LACt2
product: MODEL1310110011#
reversible: true
is: SBO:0000185
modifier: MODEL1310110011#
fast: false
type: Reaction
name: D-lactate transport via proton symport
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
is described by: ECO:0000269

metaR FRUt4
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
type: Reaction
product: MODEL1310110011#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
name: D-fructose transport via sodium cotransport
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110011#_5690fbc3_a993_476a_afe4_0621d5632c4a
has only substance units: false
type: Species
is: SBO:0000252
name: B3GNT7
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:93010
is: Q8NFL0
constant: false

metaM dgpi prot hs r
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: HMDB02925
name: deacylated-glycophosphatidylinositol (GPI)-anchored protein
initial concentration: 1.0
is: CHEBI:53486
notes: FORMULA: C39H76N4O37P4FULLRCO2FULLR2CO2X CHARGE: 0

metaM h2o2 x
is: CHEBI:16240
boundary condition: false
is: SBO:0000247
is: HMDB03125
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
name: Hydrogen peroxide
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: C00027
constant: false

metaM mercplaccys c
is: HMDB06512
name: 3-mercaptolactate-cysteine disulfide
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1

metaM tdcoa c
name: Tetradecanoyl-CoA (n-C14:0CoA)
initial concentration: 1.0
is: HMDB01521
constant: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:57385
initial amount: NaN
is: C02593

metaR UAGDP
kinetic law: MODEL1310110011#
reversible: false
product: MODEL1310110011#
name: UDP-N-acetylglucosamine diphosphorylase
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110011#
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.23
modifier: MODEL1310110011#

metaR r2322
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110011#
reversible: true

metaM 3octdece1crn c
notes: FORMULA: C25H47NO5 CHARGE: 0
initial concentration: 1.0
name: 3-hydroxy-octadecenoyl carnitine
has only substance units: false
constant: false
initial amount: NaN
is: HMDB13336
boundary condition: false
type: Species
is: SBO:0000247

metaM 10fthf e
boundary condition: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
name: 10-formyltetrahydrofolate(2-)
initial concentration: 1.0
type: Species
is: CHEBI:57454
has only substance units: false
constant: false
is: HMDB00972
is: SBO:0000247
initial amount: NaN

metaM ksi pre35 g
initial concentration: 1.0
type: Species
is: CHEBI:28067
constant: false
name: keratan sulfate I biosynthesis, precursor 35
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
is: SBO:0000247

metaR r0784
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
modifier: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: true
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:

metaM msa m
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
is: HMDB11111
boundary condition: false
type: Species
is: CHEBI:33190
name: 3-oxopropanoate
constant: false

metaR FATP2t
modifier: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
fast: false
kinetic law: MODEL1310110011#
name: fatty acid electroneutral transport
is: SBO:0000185
product: MODEL1310110011#
type: Reaction
reversible: true

metaM gmp c
constant: false
initial concentration: 1.0
is: C00144
is: SBO:0000247
boundary condition: false
is: CHEBI:58115
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
type: Species
name: GMP
is: HMDB01397
initial amount: NaN
has only substance units: false

metaR PRO1x
reactant: MODEL1310110011#
modifier: MODEL1310110011#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.99.8
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Transport, extracellular EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
product: MODEL1310110011#
name: L-ProlineNAD+ 5-oxidoreductase
reversible: false
kinetic law: MODEL1310110011#

metaM creat e
initial amount: NaN
name: creatine
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00064
constant: false
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
type: Species
is: CHEBI:16919
is: SBO:0000247

metaR EX c10dc
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for sebacoyl carnitine
type: Reaction

metaR r2323
is: SBO:0000185
product: MODEL1310110011#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110011#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110011#_c318622a_174e_4ee9_91e2_4e34100074c6
is encoded by: hsa:277
constant: false
has only substance units: false
is: P04745
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: AMY1B
initial amount: NaN

metaR PI45PLC
is version of: http://identifiers.org/ec-code/3.1.4.11
reversible: false
reactant: MODEL1310110011#
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
is described by: ECO:0000000
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
product: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
type: Reaction
is: SBO:0000176

metaR r2324
product: MODEL1310110011#
reversible: true
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_41da8b60_f497_4332_8775_b64f5123e843
boundary condition: true
type: Species
name: GPX6
is: P59796
is: SBO:0000252
is encoded by: hsa:257202
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN

metaR r1899
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: false
fast: false
is described by: ECO:0000000
modifier: MODEL1310110011#
product: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is: SBO:0000185

metaM pail345p hs c
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
initial concentration: 1.0
constant: false
is: CHEBI:57836
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false

metaR DIDPtn
reversible: true
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
product: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000000
name: dIDP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false

metaR DM 4abut LPAREN n RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID: 16643338 NOTES:GABA in the intestine may aid in differentiation and proliferation of epithelial cells. GABA intake by oral administration has been shown to alleviate stress, worry and anxiety and additionally it can also improve human immunity (PMID: 16971751). However the PAT1 transporter located at the apical side of enterocytes have very low affinity for GABA. I have presumed that this oral GABA is used within intestine (unless administered at high very high pharmacological doses, GABA exit from the enterocytes may be mediated by other specifc transporters).
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for 4-Aminobutanoate(n)
type: Reaction

metaM mercplaccys e
name: 3-mercaptolactate-cysteine disulfide
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
is: HMDB06512
is: SBO:0000247
constant: false

metaR FAOXC141C121m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C12:1)m
type: Reaction

metaR C12DCTD
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Dodecanedioic acid by diffusion
type: Reaction

metaR r0783
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110011#
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
kinetic law: MODEL1310110011#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
reactant: MODEL1310110011#
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM thbpt4acam n
has only substance units: false
type: Species
name: 4a-hydroxytetrahydrobiopterin
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:15374
is: HMDB02281
initial concentration: 1.0
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_f263680b_5f30_4b24_b5c0_9e5ddcd4866a
boundary condition: true
is: P13073
has only substance units: false
name: COX4I1
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1327

metaR NDP8ex
reversible: false
fast: false
reactant: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000176
name: nucleoside-diphosphatase (UTP), extracellular
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.6.1.6
is described by: ECO:0000269

metaR OCD11CRNCACT
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR KSIt
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000000
reversible: false
fast: false
name: keratan sulfate I transport, golgi to extracellular
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110011#_5b6fd655_7a90_4518_9567_ad353ca3afdd
is: SBO:0000252
is: B4DG68
constant: false
initial amount: NaN
has only substance units: false
name: NOS1
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:4842

metaM lgnccoa c
is: HMDB06526
name: lignocericyl coenzyme A
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
type: Species
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
is: SBO:0000247

metaR EX chtn LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chitin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_3dbf286a_c68e_45ca_99da_615058f4db76
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:271
type: Species
boundary condition: true
is: E9PNG0
constant: false
initial concentration: NaN
name: AMPD2

metaR FAOXC183806m
fast: false
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
kinetic law: MODEL1310110011#
name: Beta oxidation of fatty acid
modifier: MODEL1310110011#
reactant: MODEL1310110011#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

http://identifiers.org/biomodels.db/MODEL1310110011#_32e5f702_93c5_490e_b05d_835d2b2d0bb4
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
name: _LOC647190_1_c
is encoded by: hsa:LOC647190

metaR G14T13g
kinetic law: MODEL1310110011#
is described by: ECO:0000000
reversible: false
type: Reaction
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22

http://identifiers.org/biomodels.db/MODEL1310110011#_b17b0b10_08b9_42f3_90b7_6615c818809a
is: Q9NSW9
constant: false
is encoded by: hsa:6553
boundary condition: true
initial concentration: NaN
name: SLC9A5
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR CYOR u10m
is: SBO:0000185
name: ubiquinol-6 cytochrome c reductase, Complex III
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.5.1.92
fast: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
product: MODEL1310110011#
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false

metaM ksi pre2 g
initial amount: NaN
is: C00130
notes: FORMULA: C87H142N6O62X CHARGE: -1
is: SBO:0000247
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 2
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110011#_e7b22ac6_cdc5_4a54_a175_1ff780dc36e9
name: _AA526438_1_m
is encoded by: hsa:AA526438
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN

metaR BDMT L
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.4.1.142
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
product: MODEL1310110011#
reactant: MODEL1310110011#
modifier: MODEL1310110011#
fast: false
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (liver)
is described by: ECO:0000000

metaM ksi pre30 g
name: keratan sulfate I biosynthesis, precursor 30
is: HMDB00175
is: C00130
initial amount: NaN
is: CHEBI:58053
boundary condition: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_1fbbafc3_7e77_47d9_b4fa_bbff2f4575b2
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:125206
is: SBO:0000252
has only substance units: false
is: A0PJK1
name: SLC5A10
boundary condition: true
constant: false
type: Species

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaR KAS8
reactant: MODEL1310110011#
product: MODEL1310110011#
name: b-ketoacyl synthetase (palmitate, n-C16:0)
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
fast: false
kinetic law: MODEL1310110011#
is: SBO:0000176
modifier: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_dfcedc65_e3c9_4581_9374_449943efea23
initial amount: NaN
is: Q15758
boundary condition: true
has only substance units: false
is: SBO:0000252
name: SLC1A5
type: Species
initial concentration: NaN
is encoded by: hsa:6510
constant: false

metaR r0780
modifier: MODEL1310110011#
fast: false
product: MODEL1310110011#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is: SBO:0000176
reactant: MODEL1310110011#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110011#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70

metaR ADSS
modifier: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.4
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000134
fast: false
name: adenylosuccinate synthase
reversible: false

metaM c226coa m
type: Species
is: C16169
is: SBO:0000247
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
initial amount: NaN
name: cervonyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205479
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false

metaR FAOXC200180m
modifier: MODEL1310110011#
type: Reaction
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
is: SBO:0000176
fast: false
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_de5eaab3_8185_46b1_ac12_faee92638fdf
is encoded by: hsa:50
name: ACO2
initial amount: NaN
boundary condition: true
type: Species
is: Q99798
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_e00506d5_a7f9_4c06_888a_f18e64798cfc
is: O00767
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: SCD
initial amount: NaN
is encoded by: hsa:6319
constant: false
has only substance units: false
type: Species

metaR AHEXASE2ly
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110011#
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
product: MODEL1310110011#
fast: false
is described by: ECO:0000000

metaM pail45p hs c
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial amount: NaN
is: CHEBI:28910
initial concentration: 1.0
type: Species
name: phosphatidylinositol 4,5-bisphosphate
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR r2320
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110011#
product: MODEL1310110011#
reversible: true
kinetic law: MODEL1310110011#

metaR r1167
fast: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110011#
name: EC:2.3.1.26

metaR PPD2CSPp
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000176
product: MODEL1310110011#
fast: false
name: PPD2CSPp
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
reversible: false

metaM xoldioloneh c
boundary condition: false
type: Species
is: CHEBI:2288
initial amount: NaN
is: HMDB06887
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
has only substance units: false
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaR r2329
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110011#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110011#
reversible: true
is: SBO:0000185
product: MODEL1310110011#

metaR LDH D
is: SBO:0000176
name: D-lactate dehydrogenase
reactant: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
fast: false
modifier: MODEL1310110011#
is described by: ECO:0000304
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.2.4
type: Reaction
kinetic law: MODEL1310110011#

metaR r2115
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM btn c
is: SBO:0000247
name: Biotin
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
has only substance units: false
type: Species
is: C00120
is: CHEBI:3420
is: HMDB00030
initial concentration: 1.0
constant: false

metaR RNDR1
reactant: MODEL1310110011#
modifier: MODEL1310110011#
reversible: false
is: SBO:0000176
name: ribonucleoside-diphosphate reductase (ADP)
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
is described by: ECO:0000254
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_d28517b1_36af_4553_b265_e6bc9aff580f
is: SBO:0000252
name: CHST4
is encoded by: hsa:10164
has only substance units: false
is: Q8NCG5
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_74f84373_2b6d_44ad_ae52_808f8eed52ce
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:11343
is: B2ZGL7
constant: false
boundary condition: true
name: MGLL

http://identifiers.org/biomodels.db/MODEL1310110011#_1dc9c207_b8e4_46cd_a37b_9f9d5be9c40d
is encoded by: hsa:6487
type: Species
is: SBO:0000252
has only substance units: false
is: Q96L53
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
name: ST3GAL3

metaM no c
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: Nitric oxide
is: C00533
type: Species
has only substance units: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: CHEBI:16480
is: HMDB03378
initial amount: NaN

metaM c4crn m
notes: FORMULA: C11H21NO4 CHARGE: 0
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/213144
constant: false
is: HMDB02013
is: SBO:0000247
name: butyryl carnitine
boundary condition: false
has only substance units: false
is: C02862
type: Species
initial amount: NaN

metaR LCADi
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
product: MODEL1310110011#
name: lactaldehyde dehydrogenase
is described by: ECO:0000304
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.36

metaM thbpt4acam c
initial amount: NaN
has only substance units: false
name: 4a-hydroxytetrahydrobiopterin
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:15374
type: Species
is: HMDB02281
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951

http://identifiers.org/biomodels.db/MODEL1310110011#_1443f110_ef05_4901_a959_6726f32977b8
initial concentration: NaN
is encoded by: hsa:788
boundary condition: true
is: O43772
name: SLC25A20
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaM tststerone r
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial amount: NaN
type: Species
is: SBO:0000247
name: testosterone
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00234
is: CHEBI:17347

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

metaR r2116
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110011#
type: Reaction
fast: false
reactant: MODEL1310110011#
is described by: ECO:0000000

metaM pail5p hs n
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial concentration: 1.0
boundary condition: false
is: CHEBI:57795
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_e865e5ab_a025_4673_a332_3bdfdfff43a7
has only substance units: false
type: Species
initial concentration: NaN
name: CA5A
is encoded by: hsa:763
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is: P35218

metaM dcdp m
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:58593
is: SBO:0000247
constant: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial amount: NaN
name: dCDP(3-)
initial concentration: 1.0
is: HMDB01245

metaR GGH 7THFe
modifier: MODEL1310110011#
is: SBO:0000176
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (7THF), extracellular
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
product: MODEL1310110011#

metaR UGT1A10r
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
is version of: http://identifiers.org/ec-code/2.4.1.17
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000176
type: Reaction
reversible: true
reactant: MODEL1310110011#
fast: false
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110011#_9ca344d1_b13c_44f1_9a03_10bd72360ff1
boundary condition: true
is encoded by: hsa:212
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is: Q5JZF5
name: ALAS2
initial concentration: NaN
initial amount: NaN

metaR r1051
name: Vesicular transport
is: SBO:0000185
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
reversible: true
reactant: MODEL1310110011#
type: Reaction

metaM gcald c
is: CHEBI:17071
initial amount: NaN
name: glycolaldehyde
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
boundary condition: false
constant: false
has only substance units: false
is: HMDB03344

http://identifiers.org/biomodels.db/MODEL1310110011#_6293c05a_2eaa_4a6c_9952_df452cc87ac0
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:2954
is: A6NED0
initial concentration: NaN
is: SBO:0000252
name: GSTZ1
type: Species

metaR 5ADTSTSTERONESte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
kinetic law: MODEL1310110011#
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110011#
product: MODEL1310110011#
name: sulfonated testosterone transport
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110011#_d4fc3d52_37f3_4c18_a97e_54b56198fed8
boundary condition: true
has only substance units: false
initial concentration: NaN
name: ALDH9A1
is encoded by: hsa:223
initial amount: NaN
is: SBO:0000252
is: P49189
constant: false
type: Species

metaR r2117
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
modifier: MODEL1310110011#
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000000

metaR r1050
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
name: Vesicular transport
fast: false
product: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110011#_5e6d9000_d70f_40ce_aab8_e70d2b4b2ea7
is: P24311
type: Species
has only substance units: false
name: COX7B
is encoded by: hsa:1349
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_77a57ddd_eefa_4141_95a4_1f8895a837a2
is: Q6IBE6
boundary condition: true
is encoded by: hsa:6484
name: ST3GAL4
has only substance units: false
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is: SBO:0000252

metaM dcdp n
name: dCDP(3-)
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:58593
is: HMDB01245
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705

metaR r0670
type: Reaction
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
fast: false
product: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_ba05ed43_666e_4894_a709_57ad4e2bdc79
boundary condition: true
is encoded by: hsa:9245
constant: false
initial amount: NaN
initial concentration: NaN
is: O95395
name: GCNT3
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_1367c747_bc08_4338_a958_05dc6bfc6921
is encoded by: hsa:10026
initial amount: NaN
type: Species
is: SBO:0000252
is: Q92643
constant: false
initial concentration: NaN
name: PIGK
boundary condition: true
has only substance units: false

metaR COt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
product: MODEL1310110011#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
name: CO transporter via diffusion

http://identifiers.org/biomodels.db/MODEL1310110011#_d5e1519e_20f5_4b1e_81e3_66c9c3f2f091
initial concentration: NaN
is: Q9NYR8
is: SBO:0000252
type: Species
name: RDH8
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:50700

metaR HDCAter
product: MODEL1310110011#
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
name: palmitate ER export
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_356caa60_2f91_47cb_8107_a827a12df8e2
initial concentration: NaN
is encoded by: hsa:5152
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
name: PDE9A
initial amount: NaN

metaM prpncoa m
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB02307
name: acryloyl-CoA(4-)
is: CHEBI:57367
boundary condition: false
constant: false
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_656041af_b717_4170_85f9_bb9ed34d2e47
name: NME1
is: P15531
initial amount: NaN
has only substance units: false
is encoded by: hsa:4830
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species

metaR r2118
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110011#
is: SBO:0000185
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110011#_b503a9f8_0a00_4d01_a874_30efc957075a
initial concentration: NaN
name: EHHADH
boundary condition: true
is encoded by: hsa:1962
has only substance units: false
type: Species
is: Q9NY65
is: SBO:0000252
constant: false
initial amount: NaN

metaM glygn4 e
is: HMDB00122
boundary condition: false
has only substance units: false
is: CHEBI:4167
notes: FORMULA: C18H31O16X CHARGE: 0
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})

metaM fe2 c
boundary condition: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: SBO:0000247
is: HMDB00692
is: CHEBI:29033
constant: false
is: C00023
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: Fe2+
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_9693dbc8_c98f_4bd0_9536_45fad82de014
initial amount: NaN
is: SBO:0000252
is: O75521
name: ECI2
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:10455
has only substance units: false

metaM triodthy e
is: HMDB00265
name: 3,3',5-triiodo-L-thyronine
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: CHEBI:18258
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaM 3hmbcoa m
initial amount: NaN
is: CHEBI:57312
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
is: HMDB01356
type: Species
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false

metaR r2111
modifier: MODEL1310110011#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
fast: false

metaM creat c
is: CHEBI:16919
name: creatine
has only substance units: false
is: HMDB00064
constant: false
initial amount: NaN
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_8e1bba3c_ac2d_49b4_b498_e82352e327b1
is: Q96DU7
initial amount: NaN
is encoded by: hsa:80271
has only substance units: false
type: Species
is: SBO:0000252
name: ITPKC
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_6f6904a3_6da8_4bbc_ac1d_1996b7ba31b5
boundary condition: true
initial concentration: NaN
is encoded by: hsa:23539
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
name: SLC16A8
constant: false
is: O95907

http://identifiers.org/biomodels.db/MODEL1310110011#_4f0d9440_ae2f_48eb_9755_608c8b5b5d7f
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: H0YMZ7
has only substance units: false
is encoded by: hsa:5151
name: PDE8A

http://identifiers.org/biomodels.db/MODEL1310110011#_b882881f_9ee8_463a_8b8e_c45dcb710bc9
constant: false
is: Q99755
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:8394
name: PIP5K1A
initial amount: NaN

metaR r2325
fast: false
reactant: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110011#
product: MODEL1310110011#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true

metaM frdp c
type: Species
initial amount: NaN
is: CHEBI:175763
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00961
name: Farnesyl diphosphate
has only substance units: false
is: C00448

metaM h2o2 m
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: CHEBI:16240
boundary condition: false
name: Hydrogen peroxide
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: C00027
is: HMDB03125

metaR FAOXC121C101m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:1-->C10:1)m
type: Reaction

metaM kynate c
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
initial concentration: 1.0
constant: false
name: kynurenate
type: Species
boundary condition: false
is: HMDB00715
is: CHEBI:58454
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR r1487
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110011#
is described by: ECO:0000000
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
name: EC:6.2.1.3
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_73b87efd_80c7_4c15_af69_0ec401860726
is: Q08499
is: SBO:0000252
name: PDE4D
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:5144
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_6905a22c_b62c_481a_be0c_890c6fe45b96
is: Q9UGH3
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9962
has only substance units: false
name: SLC23A2
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_ae4f4813_b0b9_46cf_a41a_f56d7ba2a498
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:9651
initial concentration: NaN
is: O75038
name: PLCH2
constant: false

metaR r0672
kinetic law: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110011#
product: MODEL1310110011#
reversible: true
modifier: MODEL1310110011#
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110011#_74c5f186_d54d_4962_8d76_2b117064e70e
boundary condition: true
name: SLC2A7
is: SBO:0000252
is: Q6PXP3
type: Species
is encoded by: hsa:155184
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_c0ac78b2_8627_45dd_9c30_3923a127c911
constant: false
is encoded by: hsa:8612
has only substance units: false
initial concentration: NaN
is: E9PAY8
boundary condition: true
name: PPAP2C
type: Species
is: SBO:0000252
initial amount: NaN

metaR r2112
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110011#
product: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110011#_f35bb20b_2dad_40aa_9856_92fd349d9122
has only substance units: false
is encoded by: hsa:144195
is: Q8TDB8
is: SBO:0000252
initial amount: NaN
constant: false
name: SLC2A14
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_9ac2750e_f8ec_4c1e_9259_c24c3e7bc13a
name: IDH2
constant: false
is: P48735
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3418
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252

metaR P5CR
is: SBO:0000176
fast: false
product: MODEL1310110011#
name: pyrroline-5-carboxylate reductase
reversible: false
is described by: ECO:0000134
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
type: Reaction
reactant: MODEL1310110011#

metaR EX glygn5 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 5 (glycogenin-2[1,4-Glc])
type: Reaction

metaM c226coa c
name: cervonyl coenzyme A
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205479
has only substance units: false
boundary condition: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: C16169
initial amount: NaN
is: SBO:0000247
type: Species
constant: false

metaR PI4PLC
reactant: MODEL1310110011#
type: Reaction
name: phosphatidylinositol 4-phosphate phospholipase C
reversible: false
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
fast: false
is: SBO:0000176
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.1.4.11
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000269

metaR r2326
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110011#
fast: false
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_3fd15df0_29cd_4db8_81ae_f54d51bc3040
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:5277
has part: P37287
boundary condition: true
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial amount: NaN
is encoded by: hsa:8818
is: SBO:0000297

metaM c51crn e
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB02366
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
name: tiglyl carnitine
notes: FORMULA: C12H21NO4 CHARGE: 0

metaR r2113
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110011#
modifier: MODEL1310110011#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110011#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_d04a2289_7e76_4439_bb75_cacbcf6519a2
is: Q1LZ56
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
name: SLC36A1
is encoded by: hsa:206358

metaM triodthy c
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
boundary condition: false
is: HMDB00265
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18258
has only substance units: false
is: SBO:0000247
name: 3,3',5-triiodo-L-thyronine

http://identifiers.org/biomodels.db/MODEL1310110011#_14d369c3_4396_42d9_92b2_be4948a33afd
is: SBO:0000252
type: Species
is encoded by: hsa:293
initial amount: NaN
constant: false
boundary condition: true
is: Q6I9V5
name: SLC25A6
initial concentration: NaN
has only substance units: false

metaM btn e
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: C00120
boundary condition: false
constant: false
is: SBO:0000247
type: Species
name: Biotin
is: CHEBI:3420
is: HMDB00030
notes: FORMULA: C10H15N2O3S CHARGE: -1

metaM pglyc hs c
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: CHARGE: 0
constant: false
is: CHEBI:15589
boundary condition: false
name: pglyc_hs[c]
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00156

metaR r2327
is: SBO:0000185
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
fast: false

metaM no e
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
name: Nitric oxide
is: C00533
is: HMDB03378
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:16480

metaR ACETONEt2m
reactant: MODEL1310110011#
name: acetone mitochondrial transport via proton symport
reversible: true
product: MODEL1310110011#
modifier: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000185
fast: false
kinetic law: MODEL1310110011#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110011#_f0174402_198f_4089_b377_e2c74f8ea9bf
is: SBO:0000252
is encoded by: hsa:U37519
name: _U37519_1_e
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_978d4e99_65dc_4cb6_b171_4c134e2c01fb
constant: false
name: _AU149534_1_e
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:AU149534

metaR RE1519M
reversible: true
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.99.13
is described by: ECO:0000000
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110011#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
name: RE1519
reactant: MODEL1310110011#
is: SBO:0000176

metaR r2114
reversible: true
fast: false
reactant: MODEL1310110011#
is: SBO:0000185
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#

metaR BTNt2
is described by: ECO:0000269
fast: false
product: MODEL1310110011#
reactant: MODEL1310110011#
name: Biotin reversible transport via proton symport
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
kinetic law: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_4e32b232_6803_4276_a4da_dbf01f73f0d9
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
name: PCBD1
is encoded by: hsa:5092
initial amount: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_4566992f_471c_4e43_9f1f_c47ee073a6d8
has only substance units: false
name: NDUFA4L2
initial amount: NaN
is encoded by: hsa:56901
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: Q9NRX3
is: SBO:0000252

metaR CO2tm
type: Reaction
is: SBO:0000185
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
kinetic law: MODEL1310110011#
fast: false
name: CO2 transport (diffusion), mitochondrial
is described by: ECO:0000000
reversible: true
product: MODEL1310110011#

metaR r2328
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
type: Reaction
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110011#
reversible: true
reactant: MODEL1310110011#

metaM c51crn c
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB02366
name: tiglyl carnitine
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C12H21NO4 CHARGE: 0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_bed200dd_0be0_4432_96b2_1fc0882690ea
boundary condition: true
constant: false
is: P23743
is encoded by: hsa:1606
type: Species
is: SBO:0000252
initial concentration: NaN
name: DGKA
initial amount: NaN
has only substance units: false

metaR GLNALANaEx
reactant: MODEL1310110011#
fast: false
reversible: false
type: Reaction
product: MODEL1310110011#
is: SBO:0000185
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)
is described by: ECO:0000269
modifier: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_61e03124_f441_4228_bcc8_7345104e6805
type: Species
boundary condition: true
is encoded by: hsa:2678
is: SBO:0000252
name: GGT1
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P19440
constant: false

metaR AKR1C42
product: MODEL1310110011#
modifier: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.225
is: SBO:0000176
kinetic law: MODEL1310110011#
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
type: Reaction
reactant: MODEL1310110011#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110011#_8c60183d_8703_4d7c_994b_6af81ae22b88
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is: O14561
is encoded by: hsa:4706
type: Species
name: NDUFAB1

metaR DHAAt1r
fast: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
reversible: true
name: dehydroascorbate transport (uniport)
modifier: MODEL1310110011#
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_1d8e0b3c_c0e5_4da9_9864_4aa0362ef9a2
initial amount: NaN
is: Q86VV3
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:953
constant: false
boundary condition: true
type: Species
name: ENTPD1

metaM ump n
name: UMP(2-)
constant: false
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:57865
initial concentration: 1.0
is: HMDB00288
is: SBO:0000247
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

metaR VALt4
is described by: ECO:0000304
reactant: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#
modifier: MODEL1310110011#
type: Reaction
is: SBO:0000185
reversible: false
name: L-valine transport in via sodium symport
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB

metaM gua c
type: Species
initial concentration: 1.0
is: CHEBI:16235
is: HMDB00132
initial amount: NaN
boundary condition: false
is: C00242
has only substance units: false
name: Guanine
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_73df93e1_c7a6_4ed6_84c1_6fd8e4e6b4bf
boundary condition: true
is: A8K003
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:5372
initial concentration: NaN
name: PMM1

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_2f0bd989_3fc5_4c26_a561_c8ce64a56cd4
initial concentration: NaN
is: SBO:0000252
constant: false
is: Q53YB7
is encoded by: hsa:1329
boundary condition: true
name: COX5B
initial amount: NaN
type: Species
has only substance units: false

metaR GCHOLAte
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110011#
name: bile acid intracellular transport
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_8da09c2a_0055_4026_8de3_8afef7b53130
is: Q9GZR5
boundary condition: true
name: ELOVL4
constant: false
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:6785
initial concentration: NaN
initial amount: NaN

metaR r0679
reversible: true
reactant: MODEL1310110011#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
product: MODEL1310110011#

metaM udp n
type: Species
is: HMDB00295
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:58223
name: UDP(3-)
is: SBO:0000247

metaM HC01118 r
initial amount: NaN
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
boundary condition: false
is: SBO:0000247
constant: false
name: presqualene diphosphate(3-)
type: Species
initial concentration: 1.0
is: CHEBI:57310
has only substance units: false

metaR TREHe
type: Reaction
reactant: MODEL1310110011#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110011#
name: alpha,alpha-trehalase
modifier: MODEL1310110011#
product: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.28
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR

metaR MECOAS1m
kinetic law: MODEL1310110011#
is described by: ECO:0000304
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
modifier: MODEL1310110011#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.4
reversible: true
product: MODEL1310110011#
name: mesaconate--CoA ligase (GDP-forming)
is: SBO:0000176

metaR r0345
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
modifier: MODEL1310110011#
type: Reaction
product: MODEL1310110011#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.99.13
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.3.6
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:

metaM ksii core2 pre10 g
is: CHEBI:28067
constant: false
has only substance units: false
type: Species
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 10
is: SBO:0000247

metaM udpgal e
boundary condition: false
name: UDP-D-galactose(2-)
constant: false
has only substance units: false
is: CHEBI:58439
type: Species
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial amount: NaN
is: HMDB00302
is: SBO:0000247
initial concentration: 1.0

metaM 5fthf m
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB01562
is: CHEBI:57457
constant: false
type: Species
has only substance units: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
name: 5-formyltetrahydrofolate(2-)
boundary condition: false

metaR GLNASNNaEx
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
name: L-glutamine/L-asparagine Na-dependent exchange (Gln-L in)
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
reactant: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000269
fast: false
type: Reaction

metaM succoa m
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
is: HMDB01022
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: Succinyl-CoA
is: CHEBI:57292

http://identifiers.org/biomodels.db/MODEL1310110011#_0388c3a9_5120_4a91_bc6b_df047de01c68
name: MGLL
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is: Q99685
is encoded by: hsa:11343
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_177a5f25_ceb5_4063_852a_8c2185bd2c51
is encoded by: hsa:4357
has only substance units: false
initial amount: NaN
is: P25325
boundary condition: true
name: MPST
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaR TETTET6COAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: fatty acid intracellular transport
reversible: true
reactant: MODEL1310110011#

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaM gua e
type: Species
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: HMDB00132
name: guanine
is: CHEBI:16235
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaM Lpipecol x
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
constant: false
name: L-pipecolic acid
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:30913
is: SBO:0000247
is: HMDB00716
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_dcb64a16_d1fd_47da_89fa_cecaca9abea5
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:8372
has only substance units: false
initial amount: NaN
name: HYAL3
constant: false
is: SBO:0000252
is: O43820

http://identifiers.org/biomodels.db/MODEL1310110011#_ab51a277_4396_44b1_a594_475b3cba6e55
name: CAD
has only substance units: false
initial concentration: NaN
is encoded by: hsa:790
constant: false
is: SBO:0000252
initial amount: NaN
is: P27708
type: Species
boundary condition: true

metaM pi m
type: Species
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: SBO:0000247
is: CHEBI:43474
name: hydrogenphosphate
is: HMDB00973
has only substance units: false
is: C00009
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR HEX10
is version of: http://identifiers.org/ec-code/2.7.1.1
name: hexokinase (D-glucosamine:ATP)
modifier: MODEL1310110011#
type: Reaction
is: SBO:0000176
reversible: false
reactant: MODEL1310110011#
is described by: ECO:0000212
product: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
is version of: http://identifiers.org/ec-code/2.7.1.2

metaR FAOXC13C11m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C13-->C11)m
type: Reaction

metaR RE3556C
type: Reaction
kinetic law: MODEL1310110011#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110011#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
product: MODEL1310110011#
name: RE3556

metaM arachdcoa x
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
has only substance units: false
is: HMDB06523
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57368
boundary condition: false
name: arachidonoyl-CoA(4-)
type: Species
initial concentration: 1.0

metaR PI345P5P
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.56
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.86
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.1.3.36
reactant: MODEL1310110011#
is described by: ECO:0000000
fast: false
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
kinetic law: MODEL1310110011#
reversible: false
product: MODEL1310110011#

metaR RE1520M
is: SBO:0000176
modifier: MODEL1310110011#
name: RE1520
reversible: true
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110011#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110011#

metaM udpgal g
is: HMDB00302
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:58439
name: UDP-D-galactose(2-)

metaM nm2masn g
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C42H70N3O30X CHARGE: 0
is: SBO:0000247
is: C05884
constant: false
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_f8739791_dff4_4d1d_bb3b_a171e032f2f9
is encoded by: hsa:347734
initial amount: NaN
type: Species
is: Q8TB61
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: SLC35B2

metaR NDPK6m
is: SBO:0000176
reversible: true
fast: false
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
product: MODEL1310110011#
kinetic law: MODEL1310110011#
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
is described by: ECO:0000254
reactant: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM udpgal c
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:58439
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00302
name: UDP-D-galactose(2-)

metaM pi n
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
initial concentration: 1.0
type: Species
is: HMDB00973
name: hydrogenphosphate
is: SBO:0000247

metaR C180CRNt
name: C180 transport into the mitochondria
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
product: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000185
kinetic law: MODEL1310110011#
is described by: ECO:0000269
type: Reaction
fast: false
modifier: MODEL1310110011#
reversible: false

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaR NDPK6n
reversible: true
product: MODEL1310110011#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
modifier: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110011#
type: Reaction
is described by: ECO:0000304
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR 1PPDCRp
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
type: Reaction
product: MODEL1310110011#
reversible: false
name: delta1-piperideine-2-carboxylate reductase, perixosomal
kinetic law: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110011#

metaM udp r
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:58223
is: C00015
name: UDP
initial concentration: 1.0
is: HMDB00295
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_61ee393e_c6f3_48ba_b7fc_fa00ea17c57e
type: Species
is: Q6P9G0
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:124637
name: CYB5D1
constant: false
initial concentration: NaN
boundary condition: true

metaM oaa m
is: CHEBI:16452
is: SBO:0000247
boundary condition: false
is: HMDB00223
type: Species
is: C00036
constant: false
initial concentration: 1.0
initial amount: NaN
name: Oxaloacetate
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
has only substance units: false

metaR PNTEH
reversible: false
modifier: MODEL1310110011#
fast: false
name: Hydrolase Class ( RXN R02973)
is: SBO:0000176
product: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.92
reactant: MODEL1310110011#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110011#_864d507e_1027_46a0_8aff_e8950b910f2d
is encoded by: hsa:5277
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
name: PIGA
boundary condition: true

metaR CMPACNAtn
reversible: false
name: CMP-Sia nuclear export
product: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110011#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_8b3078f1_7ca4_4dde_b140_4c91997031a2
type: Species
boundary condition: true
is: P04035
is encoded by: hsa:3156
constant: false
name: HMGCR
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_da5cf60a_1a06_4f9d_ac8c_eb38c7047154
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
name: VNN3
initial concentration: NaN
is encoded by: hsa:55350

metaR NTP3e
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.6
product: MODEL1310110011#
fast: false
name: nucleoside-triphosphatase (GTP)
reversible: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000269
modifier: MODEL1310110011#

metaR PETOHMr hs
kinetic law: MODEL1310110011#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.1.1.17
modifier: MODEL1310110011#
name: phosphatidylethanolamine N-methyltransferase
reversible: false
is described by: ECO:0000254
product: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-Prot] NJ

metaR EX tethex3 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosahexaenoic acid, n-3 exchange
type: Reaction

metaM amp x
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00045
has only substance units: false
name: AMP
is: C00020
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial amount: NaN
constant: false
is: CHEBI:456215

http://identifiers.org/biomodels.db/MODEL1310110011#_063c4863_63db_42a4_af46_d105e34d369c
name: ENTPD4
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:9583
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q9Y227

http://identifiers.org/biomodels.db/MODEL1310110011#_29b5ebc3_31b4_4d1c_bacf_a822834d2dbd
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: O75452
boundary condition: true
name: RDH16
is encoded by: hsa:8608
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_6207221f_294f_4f62_a86b_1c41f8cc1e79
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110011#_d751a54e_f04a_46ea_8fe6_5d13fee8f4e7
is: SBO:0000252
has only substance units: false
is: P30838
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:218
name: ALDH3A1

http://identifiers.org/biomodels.db/MODEL1310110011#_4e2f7dc4_5268_49ca_a37e_59c792e2b2d4
constant: false
name: NUDT12
type: Species
has only substance units: false
is encoded by: hsa:83594
boundary condition: true
initial concentration: NaN
is: Q9BQG2
initial amount: NaN
is: SBO:0000252

metaR r0081
is version of: http://identifiers.org/ec-code/1.5.1.12
is described by: ECO:0000000
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
is: SBO:0000176
type: Reaction
reactant: MODEL1310110011#
fast: false
reversible: true
product: MODEL1310110011#

metaR C12DCe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C12DC
type: Reaction

metaR FALDH
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110011#
reversible: true
product: MODEL1310110011#
name: formaldehyde dehydrogenase

metaM crm hs e
constant: false
is: SBO:0000247
type: Species
name: N-acylsphingosine
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:52639
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195

metaM 44mctr r
type: Species
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
is: CHEBI:17813
constant: false
initial concentration: 1.0
boundary condition: false
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
is: HMDB01023
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM succoa c
has only substance units: false
name: Succinyl-CoA
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
type: Species
constant: false
is: HMDB01022

metaM pi r
is: C00009
has only substance units: false
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: HMDB00973
is: CHEBI:43474
boundary condition: false
initial concentration: 1.0
name: hydrogenphosphate
is: SBO:0000247
constant: false
type: Species

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaM i c
boundary condition: false
is: CHEBI:16382
initial amount: NaN
is: SBO:0000247
name: iodide
initial concentration: 1.0
is: HMDB12238
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
type: Species
has only substance units: false
constant: false

metaM hexc c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
name: cerotate
is: HMDB02356
type: Species
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
is: CHEBI:31013
has only substance units: false

metaR HMGLx
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/4.1.3.4
reactant: MODEL1310110011#
name: hydroxymethylglutaryl-CoA lyase
reversible: false
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
product: MODEL1310110011#

metaM tettet6coa x
is: HMDB06516
constant: false
is: C16171
name: tetracosatetraenoyl coenzyme A
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205481
is: SBO:0000247
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
initial amount: NaN
type: Species

metaR r0946
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction
reversible: true

metaM ump g
is: CHEBI:57865
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: UMP(2-)
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
constant: false
is: SBO:0000247
is: HMDB00288

metaM arachdcoa r
is: SBO:0000247
name: arachidonoyl-CoA(4-)
initial amount: NaN
is: HMDB06523
boundary condition: false
constant: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
has only substance units: false
is: CHEBI:57368
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_9c5c38f6_4a70_47a2_8ea3_83e274702025
type: Species
name: MYO5B
is encoded by: hsa:4645
boundary condition: true
is: SBO:0000252
is: Q9H6Y6
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN

metaM 2dpmhobq m
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C58H88O4 CHARGE: 0 INCHI: InChI=1S/C58H88O4/c1-43(2)23-14-24-44(3)25-15-26-45(4)27-16-28-46(5)29-17-30-47(6)31-18-32-48(7)33-19-34-49(8)35-20-36-50(9)37-21-38-51(10)39-22-40-52(11)41-42-54-53(12)55(59)57(61)58(62-13)56(54)60/h23,25,27,29,31,33,35,37,39,41,61H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b44-25+,45-27+,46-29+,47-31+,48-33+,49-35+,50-37+,51-39+,52-41+
constant: false
is: CHEBI:50771
has only substance units: false
initial amount: NaN
name: 2-decaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone
is: HMDB06484
type: Species
boundary condition: false

metaR r0340
type: Reaction
fast: false
kinetic law: MODEL1310110011#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is version of: http://identifiers.org/ec-code/1.3.1.38
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110011#
reactant: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000176

metaR r0083
reactant: MODEL1310110011#
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
product: MODEL1310110011#
reversible: true
is: SBO:0000176
type: Reaction
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.1.42

metaM pep m
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
is: HMDB00263
is: CHEBI:18021
name: Phosphoenolpyruvate
boundary condition: false
is: C00074

http://identifiers.org/biomodels.db/MODEL1310110011#_1435de74_2cd1_45a9_bc20_d9bb7bd3c2b8
constant: false
is: SBO:0000252
name: KHK
is: P50053
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3795
boundary condition: true
has only substance units: false

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

metaR ARAB Lt
name: L-arabinoase extracellular transport
reactant: MODEL1310110011#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
type: Reaction
product: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110011#_d024d307_2a74_4d79_8f14_d30b5ccdcbd2
is: Q15392
initial amount: NaN
is encoded by: hsa:1718
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
name: DHCR24

metaR r1177
name: EC:3.1.1.13
reversible: false
product: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
reactant: MODEL1310110011#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110011#
fast: false

metaM sph1p e
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: HMDB01383
has only substance units: false
is: CHEBI:57939
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
constant: false
initial amount: NaN

metaM inost e
is: SBO:0000247
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
initial concentration: 1.0
name: myo-inositol
initial amount: NaN
is: HMDB00211
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:17268

metaR r0084
reactant: MODEL1310110011#
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reversible: true
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110011#
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.1.42
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110011#_856a46f3_939a_4d76_a90f_86fcd6a1447b
initial amount: NaN
is encoded by: hsa:6535
initial concentration: NaN
is: B4DIA3
has only substance units: false
constant: false
is: SBO:0000252
type: Species
name: SLC6A8
boundary condition: true

metaR ALCD21 D
modifier: MODEL1310110011#
is described by: ECO:0000304
fast: false
is: SBO:0000176
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
type: Reaction
name: alcohol dehydrogenase (D-1,2-propanediol)
product: MODEL1310110011#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.1
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.99.24

metaR TSTSTERONEtr
is described by: ECO:0000000
product: MODEL1310110011#
is: SBO:0000185
type: Reaction
reversible: true
name: testosterone intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110011#
fast: false
reactant: MODEL1310110011#

metaR MAGt
is: SBO:0000185
fast: false
is described by: ECO:0000269
reactant: MODEL1310110011#
product: MODEL1310110011#
name: monoacylglycerol 2 transport
kinetic law: MODEL1310110011#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:10344773 NOTES:

metaR CMPACNAtg
is: SBO:0000185
modifier: MODEL1310110011#
name: CMP-Sia Golgi transport via CMP antiport
is described by: ECO:0000269
reactant: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
reversible: true
product: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD

metaR r0789
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reactant: MODEL1310110011#
reversible: true
modifier: MODEL1310110011#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110011#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
product: MODEL1310110011#

metaM lgnccoa x
is: SBO:0000247
has only substance units: false
boundary condition: false
name: lignocericyl coenzyme A
initial amount: NaN
is: HMDB06526
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110011#_901697ea_6b86_4e3f_99ae_785c3df7bfe6
type: Species
is: SBO:0000252
name: NDUFA10
has only substance units: false
is: O95299
constant: false
is encoded by: hsa:4705
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR EX nrvnc LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nervonic acid exchange
type: Reaction

metaM ump e
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57865
type: Species
is: HMDB00288
boundary condition: false
name: UMP(2-)
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
constant: false
has only substance units: false

metaM HC01399 m
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
name: (S)-3-Hydroxytetradecanoyl-CoA
is: CHEBI:27466
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
constant: false

metaR r0944
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
is: SBO:0000185
name: Active transport
type: Reaction
kinetic law: MODEL1310110011#

metaR r0085
is described by: ECO:0000000
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.1.42
fast: false
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
kinetic law: MODEL1310110011#
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110011#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3

metaM l2fn2m2masn g
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:28067
constant: false
initial concentration: 1.0
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
type: Species
notes: FORMULA: C68H113N4O49X CHARGE: 0
initial amount: NaN

metaR ARABR
is: SBO:0000176
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
name: arabinose reductase
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.1.21
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: false
modifier: MODEL1310110011#

metaR DM T antigen g
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

metaR r0941
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110011#
name: Free diffusion
fast: false
product: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
is described by: ECO:0000000

metaM sph1p c
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB01383
is: CHEBI:57939
boundary condition: false
is: SBO:0000247
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
type: Species
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
has only substance units: false

metaM inost c
is: HMDB00211
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
name: myo-inositol
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:17268

metaR RE1531M
name: RE1531
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
reactant: MODEL1310110011#

metaR r0787
modifier: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
product: MODEL1310110011#
kinetic law: MODEL1310110011#
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
reversible: false
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
reactant: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.1

metaR FACOAL246 1
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
is described by: ECO:0000000
modifier: MODEL1310110011#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#
type: Reaction

metaM 3ddecdicoa m
type: Species
is: SBO:0000247
is: C05280
initial concentration: 1.0
name: 3,6-dodecadienoylcoa
initial amount: NaN
constant: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
is: HMDB03952

http://identifiers.org/biomodels.db/MODEL1310110011#_7a24f95e_f4a6_4bfb_a87d_291f9981fba9
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AI024818
name: _AI024818_1_c
type: Species
constant: false
is: SBO:0000252

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaR FTCD
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
name: formimidoyltransferase cyclodeaminase
is version of: http://identifiers.org/ec-code/2.1.2.5
reversible: false
product: MODEL1310110011#

metaR FAOXC5C5OHm
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C5OH)m
type: Reaction

metaR ARACHCPT1
kinetic law: MODEL1310110011#
reversible: false
modifier: MODEL1310110011#
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110011#
type: Reaction
fast: false

metaM sbcoa c
is: HMDB00791
is: C02838
initial amount: NaN
has only substance units: false
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
name: suberylcoa
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false

metaR RAI2
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
kinetic law: MODEL1310110011#
name: retinal isomerase (9-cis)
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000176
product: MODEL1310110011#

metaR r0942
is described by: ECO:0000000
reversible: true
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
fast: false
reactant: MODEL1310110011#
is: SBO:0000185
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
kinetic law: MODEL1310110011#
type: Reaction

metaM octd11ecoa m
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
has only substance units: false
constant: false
name: 11-octadecenoylcoa
is: SBO:0000247
boundary condition: false
is: HMDB06294
initial amount: NaN
type: Species
initial concentration: 1.0

metaM ump c
is: HMDB00288
has only substance units: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
name: UMP
initial concentration: 1.0
is: C00105
is: CHEBI:57865
type: Species

metaM s7p c
initial amount: NaN
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
is: C05382
is: HMDB01068
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
name: Sedoheptulose 7-phosphate
is: CHEBI:57483
is: SBO:0000247
type: Species

metaR r0788
kinetic law: MODEL1310110011#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
modifier: MODEL1310110011#
type: Reaction
reversible: true
product: MODEL1310110011#
is: SBO:0000176
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reactant: MODEL1310110011#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_4eca799c_8da5_4c6c_a0be_1536729042d4
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: GGT2
initial amount: NaN
boundary condition: true
is encoded by: hsa:728441
constant: false

metaR ARACHCPT2
modifier: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
name: carnitine transferase
kinetic law: MODEL1310110011#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110011#_635e51a4_c076_4c05_8db7_4cc8fcad0286
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:5805
is: Q03393
name: PTS
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN

metaM odecoa x
initial amount: NaN
name: oleoyl-CoA(4-)
type: Species
constant: false
is: CHEBI:57387
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
is: HMDB01322
boundary condition: false

metaM pi x
has only substance units: false
is: CHEBI:43474
type: Species
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
is: HMDB00973
name: hydrogenphosphate
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0

metaM arachdcoa m
is: SBO:0000247
type: Species
has only substance units: false
name: arachidonoyl-CoA(4-)
is: HMDB06523
initial concentration: 1.0
is: CHEBI:57368
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_0f7ae0bd_a134_457e_b8d1_b47080ae8906
initial concentration: NaN
has only substance units: false
boundary condition: true
name: NT5C2
is: P49902
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:22978

metaR DAGK hs
is: SBO:0000176
kinetic law: MODEL1310110011#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.107
name: Diacylglycerol phosphate kinase (homo sapiens)
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110011#
reversible: true
reactant: MODEL1310110011#
is described by: ECO:0000269
fast: false

metaR IDPtn
reactant: MODEL1310110011#
product: MODEL1310110011#
name: IDP nuclear transport
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction

metaR CLPNDt
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110011#

metaM hexc e
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB02356
is: CHEBI:31013
name: cerotate
initial amount: NaN

metaR r0236
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.6
reversible: true
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
fast: false
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
product: MODEL1310110011#
is described by: ECO:0000000
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
type: Reaction

metaM i e
is: CHEBI:16382
initial amount: NaN
constant: false
is: HMDB12238
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
name: iodide
boundary condition: false

metaM pacald c
is: CHEBI:16424
name: phenylacetaldehyde
boundary condition: false
constant: false
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB06236
initial amount: NaN

metaR r0940
type: Reaction
kinetic law: MODEL1310110011#
fast: false
is described by: ECO:0000000
product: MODEL1310110011#
reactant: MODEL1310110011#
reversible: true
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_7e6c0d05_8e9b_4608_9b5c_5e6e6081f5ab
is: SBO:0000252
has only substance units: false
name: SLC24A2
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:25769
boundary condition: true
is: Q9UI40
initial amount: NaN

metaM ksi pre19 g
boundary condition: false
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
type: Species
has only substance units: false
constant: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 19
initial concentration: 1.0
is: HMDB00175
is: CHEBI:58053
is: C00130
initial amount: NaN

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_fd344239_849f_485f_ac79_472505c46037
initial amount: NaN
is: P00390
name: GSR
is encoded by: hsa:2936
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false
is: SBO:0000252

metaR AATAi
notes: GENE_ASSOCIATION: (51166.1) or (51166.2) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 4 AUTHORS: PMID:12126930 NOTES:MM
kinetic law: MODEL1310110011#
product: MODEL1310110011#
name: 2-aminoadipate transaminase, irreversible
is version of: http://identifiers.org/ec-code/2.6.1.7
reversible: false
modifier: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000269

metaR S6T7g
reactant: MODEL1310110011#
fast: false
modifier: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110011#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110011#
type: Reaction

metaR HSD3A2r
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
reversible: true
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
product: MODEL1310110011#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.225
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#

metaR r0796
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
is: SBO:0000176
modifier: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
reactant: MODEL1310110011#
reversible: true
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_e010316e_b0b3_468e_b6db_266e03eedd59
has only substance units: false
is encoded by: hsa:55350
is: SBO:0000252
name: VNN3
boundary condition: true
initial amount: NaN
type: Species
constant: false
initial concentration: NaN

metaR TALA
reactant: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.2.1.2
kinetic law: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
reversible: true
is: SBO:0000176
type: Reaction
modifier: MODEL1310110011#
name: transaldolase

http://identifiers.org/biomodels.db/MODEL1310110011#_dc82e4d1_d4e0_496d_bc58_5c3e5c196767
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: PDXP
is encoded by: hsa:57026
is: Q96GD0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_53b7f53e_c002_4b94_b207_3d99f3f7f05b
type: Species
is: G5E9C5
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8654
name: PDE5A
has only substance units: false
initial concentration: NaN

metaM CE4876 r
is: SBO:0000247
boundary condition: false
name: delta12-Prostaglandin J2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
type: Species
initial concentration: 1.0
is: CHEBI:12947
has only substance units: false
constant: false
initial amount: NaN

metaR KHK
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.3
modifier: MODEL1310110011#
reversible: false
name: ketohexokinase
kinetic law: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110011#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110011#

metaR FAOXC164C143m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_b96abcbf_5e92_44d6_b933_85207d071a94
name: SYNJ1
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: O43426
is encoded by: hsa:8867
is: SBO:0000252

metaM HC02216 e
is: CHEBI:28922
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
constant: false
name: prostaglandin-f2beta
has only substance units: false
boundary condition: false
initial amount: NaN

metaM Rtotal2 e
initial amount: NaN
is: SBO:0000247
is: CHEBI:3554
name: R total 2 position
is: HMDB00244
constant: false
type: Species
notes: FORMULA: CO2FULLR2 CHARGE: -1
initial concentration: 1.0
is: C00255
boundary condition: false
has only substance units: false

metaM C02470 c
boundary condition: false
is: C02470
is: SBO:0000247
is: HMDB00881
initial amount: NaN
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
type: Species
initial concentration: 1.0
has only substance units: false
name: Xanthurenic acid
constant: false
is: http://identifiers.org/pubchem.compound/5485

metaR FAOXC225m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

metaR NDP3ex
modifier: MODEL1310110011#
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
type: Reaction
reversible: false
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.6.1.6
name: nucleoside-diphosphatase (GDP), extracellular

metaR SERGLNexR
reactant: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
is: SBO:0000185
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reversible: true
modifier: MODEL1310110011#
name: L-Serine/Glutamine reversible exchange
type: Reaction

metaM odecoa r
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
has only substance units: false
name: oleoyl-CoA(4-)
boundary condition: false
type: Species
is: CHEBI:57387
constant: false
is: SBO:0000247
is: HMDB01322
initial amount: NaN

metaR RE3245C
product: MODEL1310110011#
reactant: MODEL1310110011#
name: RE3245
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
reversible: true
kinetic law: MODEL1310110011#
is: SBO:0000176
fast: false

metaR FBA
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/4.1.2.13
is described by: ECO:0000134
type: Reaction
name: fructose-bisphosphate aldolase
reactant: MODEL1310110011#
is: SBO:0000176
reversible: true
fast: false

metaM amp e
name: AMP
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: C00020
type: Species
initial amount: NaN
is: HMDB00045
boundary condition: false
constant: false
is: CHEBI:456215
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR r2333
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110011#
is: SBO:0000185
product: MODEL1310110011#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110011#
fast: false

metaR PROt4 2 r
name: Proline transport (sodium symport) (2:1)
kinetic law: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
is described by: ECO:0000006
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
reversible: true
fast: false

metaR THBPT4ACAMDASE
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.2.1.96
product: MODEL1310110011#
reversible: false
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
fast: false

metaR ASNSERNaEx
name: L-serine/L-asparagine Na-dependent exchange (Asn-L in)
is described by: ECO:0000269
modifier: MODEL1310110011#
reversible: false
product: MODEL1310110011#
fast: false
is: SBO:0000185
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaM HC02216 c
initial amount: NaN
is: CHEBI:28922
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
name: prostaglandin-f2beta
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM man g
is: CHEBI:16024
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: HMDB00169
type: Species
initial amount: NaN
boundary condition: false
constant: false
name: D-mannose
initial concentration: 1.0
is: SBO:0000247

metaM Rtotal2 c
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: R total 2 position
boundary condition: false
is: CHEBI:60377
initial concentration: 1.0
is: C00055
is: HMDB00095
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_38354259_1703_4f08_80ab_b73148a30160
initial concentration: NaN
is: Q9UJ70
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:55577
name: NAGK
constant: false
boundary condition: true

metaR ALCD21 L
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.1
kinetic law: MODEL1310110011#
is: SBO:0000176
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
modifier: MODEL1310110011#
reversible: false
reactant: MODEL1310110011#
type: Reaction
product: MODEL1310110011#
name: alcohol dehydrogenase (L-1,2-propanediol)
is version of: http://identifiers.org/ec-code/1.1.99.24
is described by: ECO:0000304

metaR LEUKTRE4t
name: leukotriene E4 transport
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#

metaR r2334
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_bcbcc998_dfc1_41ea_9eb6_e0110db4542d
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is: Q6IB04
initial amount: NaN
name: PIGF
type: Species
is encoded by: hsa:5281
initial concentration: NaN

metaM amp c
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: C00020
is: CHEBI:3322
initial amount: NaN
type: Species
is: HMDB00045
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2
name: AMP

http://identifiers.org/biomodels.db/MODEL1310110011#_374b5f5b_bd7f_48f6_acdd_7a666982cac3
is encoded by: hsa:9962
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: SLC23A2
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_bd59287b_1b50_4f94_9700_debb6d79525b
constant: false
is encoded by: hsa:23464
name: GCAT
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
is: E2QC23
initial amount: NaN
has only substance units: false

metaM dpcoa e
is: CHEBI:57328
name: Dephospho-CoA
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB01373
boundary condition: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
is: C00882
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_7bff5f09_e28e_40e7_84a1_5143de9610d3
constant: false
initial concentration: NaN
is encoded by: hsa:56895
type: Species
name: AGPAT4
has only substance units: false
is: Q9NRZ5
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM man l
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
name: D-mannose
is: HMDB00169
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: CHEBI:16024
initial amount: NaN

metaR r2109
type: Reaction
kinetic law: MODEL1310110011#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
reversible: true
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_d697a1a6_1ca3_4b0e_9ed9_ed3d2cd5c1fc
is: Q3KT79
type: Species
constant: false
name: AMACR
is encoded by: hsa:23600
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM HC01231 m
is: SBO:0000247
name: N-[(R)-pantothenoyl]-L-cysteinate
is: CHEBI:58480
boundary condition: false
has only substance units: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0

metaR r2331
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110011#_4b7ce899_0487_4915_bdd3_554f86923f83
is: Q9NRA0
is encoded by: hsa:56848
has only substance units: false
name: SPHK2
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM thf m
boundary condition: false
is: CHEBI:57453
is: C00101
has only substance units: false
name: 5,6,7,8-Tetrahydrofolate
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
is: HMDB01846
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_20e99edc_c4c3_4b25_8c59_aee5d58b9eb1
is encoded by: hsa:6531
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: Q01959
name: SLC6A3

http://identifiers.org/biomodels.db/MODEL1310110011#_be360ead_aca3_407c_b587_d10b552f479f
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110011#_8257176f_a115_41c4_bb13_af49b5620c98
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P07686
is encoded by: hsa:3074
is: SBO:0000252
type: Species
name: HEXB

metaM xol27oh r
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: SBO:0000247
type: Species
is: CHEBI:17703
initial concentration: 1.0
is: HMDB02103
name: 26-hydroxycholesterol
boundary condition: false
has only substance units: false
initial amount: NaN

metaM 3oddcoa m
is: HMDB03937
is: CHEBI:27868
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
type: Species
initial concentration: 1.0
has only substance units: false
name: 3-Oxododecanoyl-CoA

metaM 20ahchsterol m
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:1296
type: Species
initial concentration: 1.0
is: HMDB06283
name: 20-hydroxycholesterol
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500

http://identifiers.org/biomodels.db/MODEL1310110011#_208eb542_7c16_4f8d_b18d_7f353bde2086
is encoded by: hsa:5152
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: PDE9A
type: Species

metaR G14T12g
product: MODEL1310110011#
reversible: false
modifier: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
kinetic law: MODEL1310110011#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_db1921fb_722a_4258_829f_4ccd752077a8
is encoded by: hsa:501
name: ALDH7A1
constant: false
has only substance units: false
type: Species
is: E7EPT3
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM odecoa m
has only substance units: false
is: HMDB01322
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:57387
is: SBO:0000247
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
constant: false
name: Octadecenoyl-CoA (n-C18:1CoA)

metaM CE1926 e
is: CHEBI:15748
initial concentration: 1.0
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00127
boundary condition: false
initial amount: NaN
name: gama-carboxyethyl-hydroxychroman
constant: false

metaR r0791
type: Reaction
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000176

metaR r2332
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185

metaM citr L m
name: L-citrulline
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: CHEBI:16349
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00904

metaR r2107
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
reactant: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_4d5b7971_0954_4736_8c27_b9b2e960a2d0
initial concentration: NaN
name: SLC38A3
is encoded by: hsa:10991
is: Q99624
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_08cb923c_4b08_417c_b783_c815221512c0
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: NDUFS5
is encoded by: hsa:4725
is: Q6IBA0
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_72537f4f_74bd_4852_9f02_f197432e4d37
is: SBO:0000252
is: P32019
is encoded by: hsa:3633
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: INPP5B
initial amount: NaN

metaM pail4p hs c
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
boundary condition: false
initial amount: NaN
is: CHEBI:58178
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277

metaM udp c
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: UDP
is: C00015
is: CHEBI:58223
initial concentration: 1.0
constant: false
is: HMDB00295
boundary condition: false

metaM pep c
boundary condition: false
is: HMDB00263
initial concentration: 1.0
has only substance units: false
constant: false
name: Phosphoenolpyruvate
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
type: Species
initial amount: NaN
is: C00074
is: SBO:0000247
is: CHEBI:18021

metaR FAEL205
name: fatty-acyl-CoA elongation (n-C20:5CoA)
fast: false
reversible: false
product: MODEL1310110011#
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
is: SBO:0000176
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction
is described by: ECO:0000000

metaR 3HBCOAHLm
reversible: false
is: SBO:0000176
type: Reaction
product: MODEL1310110011#
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000000

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaR r2108
kinetic law: MODEL1310110011#
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
product: MODEL1310110011#
is: SBO:0000185
reactant: MODEL1310110011#
is described by: ECO:0000000
modifier: MODEL1310110011#

metaM g2m8mpdol L r
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial concentration: 1.0
notes: FORMULA: C1900H3128N20O720P20 CHARGE: -20
is: SBO:0000247
constant: false
is: C05870
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false

metaR OBDHc
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.7.2 Confidence Level: 2 AUTHORS: NOTES:as shown in Lehninger (4th ed.) for threonine degradation MM
fast: false
is: SBO:0000176
type: Reaction
name: 2-Oxobutanoate dehydrogenase, cytosolic
product: MODEL1310110011#
is described by: ECO:0000000
reversible: false

metaM glc D r
is: HMDB00122
name: D-glucose
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: SBO:0000247
initial amount: NaN
is: CHEBI:4167

metaR r2330
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110011#
fast: false
is described by: ECO:0000000
product: MODEL1310110011#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110011#_48c20b80_39f3_43f5_a40b_e4debccf1968
is encoded by: hsa:50940
constant: false
name: PDE11A
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q9HCR9
initial concentration: NaN

metaR DNDPt23m
reactant: MODEL1310110011#
name: dTDP transport via dGTP antiport
product: MODEL1310110011#
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185

metaR r0683
is: SBO:0000176
type: Reaction
reactant: MODEL1310110011#
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
kinetic law: MODEL1310110011#
is described by: ECO:0000000
modifier: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3

metaM udp e
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
name: UDP(3-)
type: Species
is: CHEBI:58223
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: HMDB00295
has only substance units: false
initial concentration: 1.0

metaM crm hs c
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
boundary condition: false
is: CHEBI:52639
constant: false
is: SBO:0000247
name: N-acylsphingosine
initial amount: NaN

metaM HC00718 c
initial concentration: 1.0
is: SBO:0000247
type: Species
name: N-methylethanolaminium phosphate(1-)
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
boundary condition: false
constant: false
is: CHEBI:57781
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_93007ac8_e84e_4dc2_b5d8_eecf9817a81d
initial amount: NaN
is: B3KUV7
has only substance units: false
boundary condition: true
is: SBO:0000252
name: PIGA
type: Species
constant: false
is encoded by: hsa:5277
initial concentration: NaN

metaM fadh2 c
is: HMDB01197
name: FADH2(2-)
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: CHEBI:58307

metaR ADRNCRNt
fast: false
type: Reaction
name: transport into the mitochondria (carnitine)
reactant: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (788.1) or (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110011#
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000185
reversible: false

metaR FAOXC165C164m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_6b75e00e_d17b_41bc_9f84_11b1770e754d
initial amount: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: DPAGT1
is encoded by: hsa:1798

metaR r2105
fast: false
reversible: true
product: MODEL1310110011#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
modifier: MODEL1310110011#

metaM accoa c
is: SBO:0000247
constant: false
type: Species
is: HMDB01206
is: C00024
initial amount: NaN
initial concentration: 1.0
name: Acetyl-CoA
is: CHEBI:57288
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
has only substance units: false
boundary condition: false

metaR RDH3
type: Reaction
product: MODEL1310110011#
is: SBO:0000176
reversible: true
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
is described by: ECO:0000269
name: retinol dehydrogenase (11-cis,NADH)
is version of: http://identifiers.org/ec-code/1.1.1.315
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT

metaM na1 e
is: SBO:0000247
notes: FORMULA: Na CHARGE: 1
initial amount: NaN
name: Sodium
is: CHEBI:4541
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: C01330
is: HMDB00588

W3 CDTF: Fri Aug 31 00:02:06 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110011#_f98c7138_412e_4b87_a66f_6785d37951ea
type: Species
name: PDE9A
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5152

http://identifiers.org/biomodels.db/MODEL1310110011#_5c48fbb4_2384_476b_b33f_389adf04029f
is: O60312
boundary condition: true
name: ATP10A
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:57194

metaR sink c101coa LPAREN c RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C101COASINK
type: Reaction

metaR C8DCc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberylcarnitine
type: Reaction

metaR DNADtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
product: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
fast: false
name: dNAD transport, nuclear trhough pore
reversible: true
kinetic law: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_7ce96bee_62ff_44c8_bf80_6601c26a495b
name: SLC5A3
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6526
constant: false
type: Species
is: P53794
boundary condition: true
has only substance units: false
initial amount: NaN

metaR RDH1
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
product: MODEL1310110011#
name: retinol dehydrogenase (all-trans)
is: SBO:0000176
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
reversible: true
is described by: ECO:0000269
fast: false
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.1.315
type: Reaction

metaM arachdcoa c
name: arachidonoyl-CoA(4-)
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB06523
initial concentration: 1.0
is: CHEBI:57368
constant: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
initial amount: NaN

metaR r2106
product: MODEL1310110011#
modifier: MODEL1310110011#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110011#
fast: false
is described by: ECO:0000000

metaM pectindchac e
type: Species
is: HMDB03402
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C2559H3549O2539 CHARGE: -1
initial amount: NaN
name: pectin-deoxycholic acid complex
initial concentration: 1.0

metaR FAOXC2452256x
modifier: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:5,n-6 -> c22:5, n-6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/4.2.1.107
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM udp g
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: CHEBI:58223
name: UDP(3-)
is: HMDB00295
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_6de49eea_dca2_42f4_ab6d_f4c26882ca6c
is: B1AM93
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
name: NDUFA8
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4702

metaR H2O2t
fast: false
reactant: MODEL1310110011#
name: hydrogen peroxide transport via diffusion
kinetic law: MODEL1310110011#
is described by: ECO:0000000
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
reversible: true
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_796d05f2_72a5_45ea_aa45_1e95cc0418b4
initial amount: NaN
is encoded by: hsa:4351
constant: false
has only substance units: false
boundary condition: true
is: P34949
initial concentration: NaN
is: SBO:0000252
type: Species
name: MPI

metaR r2103
kinetic law: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
modifier: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185

metaM na1 c
notes: FORMULA: Na CHARGE: 1
is: HMDB00588
is: SBO:0000247
has only substance units: false
name: Sodium
is: CHEBI:4541
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: C01330

metaR FAOXC16080m
kinetic law: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
product: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR C12DCACT
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of Dodecanedioic acid
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_c236e29d_a0d8_457d_bdfb_5f6842abf479
is: SBO:0000252
has only substance units: false
is: O95954
type: Species
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
name: FTCD
is encoded by: hsa:10841

metaM amp m
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:456215
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: HMDB00045
name: AMP(2-)
type: Species
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_a95fbe36_2b10_49df_a626_cee98b75645c
is encoded by: hsa:4731
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P56181
constant: false
name: NDUFV3
has only substance units: false
initial concentration: NaN

metaM dec24dicoa m
has only substance units: false
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: 2,4-decadienoylcoa
type: Species
constant: false
is: HMDB01168

metaR r0680
kinetic law: MODEL1310110011#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
type: Reaction
modifier: MODEL1310110011#
reactant: MODEL1310110011#
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.137
reversible: true
is described by: ECO:0000000
fast: false

metaR PYDXPP
kinetic law: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
reversible: false
reactant: MODEL1310110011#
fast: false
product: MODEL1310110011#
is: SBO:0000176
name: Pyridoxal 5-phosphate phosphatase
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/3.1.3.3
notes: GENE_ASSOCIATION: (57026.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:14522954,PMID:6380540 NOTES:

metaR C8DCe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of suberyl carnitine into the extra cellular space
type: Reaction

metaR PTDCACRNt
product: MODEL1310110011#
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000000
name: pentadecanoate transport into the mitochondria
fast: false
reactant: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110011#_bee7f008_701a_4931_a4d4_161bc582c05b
is encoded by: hsa:55825
has only substance units: false
boundary condition: true
is: Q9BY49
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
name: PECR

http://identifiers.org/biomodels.db/MODEL1310110011#_184a0515_d3d9_446d_853e_c81375638e32
type: Species
is: SBO:0000252
is encoded by: hsa:2182
is: O60488
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: ACSL4
constant: false
boundary condition: true

metaM pail4p hs n
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: CHEBI:58178
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277

http://identifiers.org/biomodels.db/MODEL1310110011#_9e3a0f2e_97fb_4c44_82a1_8bbc43784bc7
type: Species
initial amount: NaN
constant: false
is: A8MU28
boundary condition: true
is: SBO:0000252
has only substance units: false
name: NAE1
initial concentration: NaN
is encoded by: hsa:8883

metaR RE0935E
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.1
reactant: MODEL1310110011#
name: RE0935
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.2.1.17
fast: false
is: SBO:0000176
product: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:

metaR r2104
modifier: MODEL1310110011#
product: MODEL1310110011#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110011#_e000a104_e341_491f_9839_8a5da986e290
has part: Q8TF08
is encoded by: hsa:4513
is encoded by: hsa:1351
is encoded by: hsa:1339
is encoded by: hsa:1345
has part: H0UI06
has part: Q53XN1
has part: P24311
is encoded by: hsa:170712
is encoded by: hsa:1329
has part: P14854
initial amount: NaN
has only substance units: false
is encoded by: hsa:1337
is encoded by: hsa:1347
is encoded by: hsa:341947
has part: Q7GXZ8
has part: P15954
has part: P13073
type: Species
is encoded by: hsa:9377
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: P12074
is encoded by: hsa:4514
is encoded by: hsa:1346
constant: false
has part: Q7GXY8
is encoded by: hsa:1327
is encoded by: hsa:84701
is encoded by: hsa:9167
has part: P20674
initial concentration: NaN
has part: Q6FGA0
has part: Q02221
has part: Q6YFQ2
is encoded by: hsa:4512
is encoded by: hsa:1350
boundary condition: true
is encoded by: hsa:125965
has part: P09669
has part: P00414
has part: P24310
is encoded by: hsa:1340
has part: Q7Z4L0
has part: Q96KJ9
is encoded by: hsa:1349
is: SBO:0000297
has part: Q53YB7

metaR SERCYSNaEx
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110011#
name: L-serine/L-cysteine Na-dependent exchange (Ser-L in)
is described by: ECO:0000269
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
reversible: false
fast: false

metaM CE5120 m
is: SBO:0000247
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: CHEBI:12947
name: trans-2-cis-8-tetradecadienoyl-CoA
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_88c00a9a_a557_4c44_924c_6ad71db0a482
is: P14324
name: FDPS
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:2224
boundary condition: true

metaM 56dthm c
is: CHEBI:27468
is: SBO:0000247
is: HMDB00079
type: Species
boundary condition: false
name: 5,6-dihydrothymine
initial concentration: 1.0
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
initial amount: NaN
has only substance units: false
constant: false

metaR r2101
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
modifier: MODEL1310110011#
fast: false
type: Reaction
reactant: MODEL1310110011#
is described by: ECO:0000000
reversible: true
product: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110011#_0538cf1f_165e_4a5f_af4a_0f624349c2a1
has only substance units: false
is encoded by: hsa:284273
is: SBO:0000252
is: Q8N4Q0
boundary condition: true
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
name: ZADH2

http://identifiers.org/biomodels.db/MODEL1310110011#_07614fc4_7c8c_4ed3_9a64_1127e007305a
name: DDOST
is: P39656
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:1650
initial concentration: NaN
has only substance units: false
type: Species

metaM thf e
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:57453
is: SBO:0000247
initial concentration: 1.0
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
has only substance units: false
is: HMDB01846
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101

http://identifiers.org/biomodels.db/MODEL1310110011#_9f94eab9_5d84_403f_a121_50fe274b3727
is encoded by: hsa:51227
type: Species
name: PIGP
initial concentration: NaN
has only substance units: false
is: P57054
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252

metaR PSYGCHe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of psyllium with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_f6939c7a_8ff9_4804_92f1_a02d268710a7
type: Species
has only substance units: false
name: ST3GAL3
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
is: Q11203
is encoded by: hsa:6487
initial concentration: NaN

metaR ACOAD10m
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
is described by: ECO:0000269
product: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
type: Reaction
is: SBO:0000176
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#

metaR TTDCRNt
reactant: MODEL1310110011#
name: transport into the mitochondria (carnitine)
is described by: ECO:0000000
modifier: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
fast: false
product: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_8ae521c3_a116_45a0_b119_ad3e51be2f60
initial amount: NaN
is: O14735
initial concentration: NaN
constant: false
is encoded by: hsa:10423
boundary condition: true
name: CDIPT
is: SBO:0000252
has only substance units: false
type: Species

metaM dpcoa m
boundary condition: false
has only substance units: false
name: 3'-dephospho-CoA(2-)
initial amount: NaN
type: Species
is: HMDB01373
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:57328
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882

metaR C142OHe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:2-OH
type: Reaction

metaR r2102
reversible: true
fast: false
reactant: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_0861c386_a8bf_4644_a988_5ca69de1367b
initial concentration: NaN
is: Q6FG42
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:4701
name: NDUFA7
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_e88f8bdc_8c5c_4570_8ab2_98f108f2e2ee
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: _100287639_1_c
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:100287639

metaM citr L e
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
has only substance units: false
is: CHEBI:16349
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00904
initial amount: NaN
type: Species
name: citr_L[e]

http://identifiers.org/biomodels.db/MODEL1310110011#_c7d72a99_823f_441a_ae2a_3b4ef292da75
constant: false
is: SBO:0000252
is: Q9H3S5
is encoded by: hsa:93183
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
name: PIGM
type: Species

W3 CDTF: Fri Aug 31 00:02:05 BST 2012

metaM amp r
is: HMDB00045
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
has only substance units: false
name: AMP
is: SBO:0000247
is: C00020
initial amount: NaN
constant: false
is: CHEBI:456215
type: Species

metaR r0686
is version of: http://identifiers.org/ec-code/2.3.2.2
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
fast: false
kinetic law: MODEL1310110011#
reversible: true
type: Reaction
modifier: MODEL1310110011#
is: SBO:0000176
reactant: MODEL1310110011#
product: MODEL1310110011#

metaR r0339
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.22
modifier: MODEL1310110011#
product: MODEL1310110011#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.2
reactant: MODEL1310110011#
reversible: false
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is version of: http://identifiers.org/ec-code/2.3.1.65

http://identifiers.org/biomodels.db/MODEL1310110011#_2c15c954_421e_45ee_9a82_4aa2bbb47e22
constant: false
has only substance units: false
name: NDUFS6
is: Q6IBC4
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4726
type: Species

metaM thp2c c
is: HMDB12130
initial amount: NaN
type: Species
boundary condition: false
name: 1-piperideine-6-carboxylate
is: CHEBI:16987
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
initial concentration: 1.0

metaM m2gacpail hs r
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:16038
type: Species
initial amount: NaN
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)

metaR PROt2r
product: MODEL1310110011#
is described by: ECO:0000304
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reversible: true
fast: false
name: L-proline reversible transport via proton symport
reactant: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000185
type: Reaction

W3 CDTF: Fri Aug 31 00:02:05 BST 2012

metaM thf c
name: 5,6,7,8-Tetrahydrofolate
is: HMDB01846
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
type: Species
initial amount: NaN
is: CHEBI:57453
constant: false
has only substance units: false
initial concentration: 1.0
is: C00101
is: SBO:0000247
boundary condition: false

metaM oaa c
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:3338
notes: FORMULA: C4H2O5 CHARGE: -2
is: HMDB00223
initial concentration: 1.0
name: Oxaloacetate
type: Species
initial amount: NaN
is: C00036

http://identifiers.org/biomodels.db/MODEL1310110011#_7be91281_68a1_4091_a0c9_784c6ea25301
has only substance units: false
is encoded by: hsa:2592
type: Species
initial amount: NaN
is: E7ET32
is: SBO:0000252
constant: false
boundary condition: true
name: GALT
initial concentration: NaN

metaM ump r
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: CHEBI:57865
is: SBO:0000247
constant: false
is: HMDB00288
type: Species
has only substance units: false
name: UMP
boundary condition: false
initial amount: NaN

metaR AHC
fast: false
kinetic law: MODEL1310110011#
type: Reaction
is version of: http://identifiers.org/ec-code/3.3.1.1
reactant: MODEL1310110011#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
is: SBO:0000176
product: MODEL1310110011#
name: adenosylhomocysteinase
modifier: MODEL1310110011#
reversible: true

metaM ksii core2 pre2 g
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 2
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: C00130
type: Species
is: SBO:0000247
notes: FORMULA: C39H63N3O28X CHARGE: -1
constant: false
is: HMDB00175

metaR EX 3ivcrn
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-isovaleryl carnitine
type: Reaction

metaR r2100
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110011#
is: SBO:0000185

metaR RE1518M
reversible: true
product: MODEL1310110011#
is described by: ECO:0000000
modifier: MODEL1310110011#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.13
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
reactant: MODEL1310110011#
name: RE1518
is: SBO:0000176
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110011#_6209fa0d_6870_4402_8846_9f386dbada6d
is: SBO:0000252
initial amount: NaN
name: ALDOB
is encoded by: hsa:229
type: Species
is: P05062
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM citr L c
has only substance units: false
initial concentration: 1.0
is: CHEBI:16349
constant: false
boundary condition: false
name: L-citrulline
is: SBO:0000247
type: Species
is: HMDB00904
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial amount: NaN

metaM cholcoaone x
type: Species
boundary condition: false
is: CHEBI:58507
has only substance units: false
initial amount: NaN
is: HMDB06891
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR r2443
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110011#
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
reversible: false
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction

metaR CITtam
name: citrate transport, mitochondrial
reversible: true
product: MODEL1310110011#
is: SBO:0000185
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction

metaR r2338
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
reversible: true
kinetic law: MODEL1310110011#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
product: MODEL1310110011#
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_0b47fce3_6238_4cd6_934d_b3959e390f6c
initial amount: NaN
is encoded by: hsa:2184
is: P16930
constant: false
is: SBO:0000252
type: Species
boundary condition: true
name: FAH
has only substance units: false
initial concentration: NaN

W3 CDTF: Fri Aug 31 00:02:06 BST 2012

metaM man c
is: SBO:0000247
boundary condition: false
name: D-Mannose
has only substance units: false
is: C00159
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: CHEBI:16024
is: HMDB00169
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_874ebeff_19cb_4051_8838_1d4b5ca90098
constant: false
is: O75874
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
name: IDH1
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3417

metaR DAGt
type: Reaction
name: diacylglycerol transport
fast: false
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110011#
is described by: ECO:0000269
reversible: true
product: MODEL1310110011#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_9f6e46e2_45ec_41b0_91dc_574d5a8d463b
is: P00338
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:3939
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
name: LDHA

http://identifiers.org/biomodels.db/MODEL1310110011#_d4f3bd18_ad53_47cf_a06e_c4d4881fbf3d
constant: false
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:206
initial concentration: NaN
name: _206_1_c
is: SBO:0000252

metaM cgly e
has only substance units: false
name: L-cysteinylglycine
boundary condition: false
type: Species
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
initial concentration: 1.0
initial amount: NaN
is: HMDB00078
is: SBO:0000247
is: CHEBI:4047
constant: false

metaR r2520
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
reactant: MODEL1310110011#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
product: MODEL1310110011#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_b381aeca_7ea9_4afb_ba08_b8384b6ac3b6
is encoded by: hsa:126328
name: NDUFA11
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: C9JT23
has only substance units: false

metaR TSTSTERONEt
name: Testosterone transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000185
product: MODEL1310110011#
fast: false
type: Reaction
reversible: true

metaR SMPD4
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
is described by: ECO:0000000
reversible: false
name: sphingomyelinase
reactant: MODEL1310110011#
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110011#

metaR PTDCAt
is: SBO:0000185
product: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
reversible: true
kinetic law: MODEL1310110011#
is described by: ECO:0000000
type: Reaction

metaR r0377
modifier: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
reversible: false
is: SBO:0000176
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110011#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110011#_a4773802_797a_419a_9746_0e73a5a6b08b
is encoded by: hsa:5092
initial concentration: NaN
is: P61457
boundary condition: true
name: PCBD1
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252

metaR 4PYRDX
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT Reaction correct??? (active transport)
is: SBO:0000185
name: 4-Pyridoxal secretion
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110011#
reversible: false
reactant: MODEL1310110011#

metaR EX paf hs LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
type: Reaction

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

metaR r0644
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
product: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
kinetic law: MODEL1310110011#
fast: false
type: Reaction
reversible: true

metaR MM6bg
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
type: Reaction
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
fast: false
modifier: MODEL1310110011#
product: MODEL1310110011#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.113

http://identifiers.org/biomodels.db/MODEL1310110011#_66cd0eec_9656_4ea5_8444_c0e76da0983a
type: Species
boundary condition: true
is encoded by: hsa:8813
is: O60762
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: DPM1
initial amount: NaN
constant: false

metaR HEXDICOAACBPx
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexadecanedioyl coa
type: Reaction

metaM HC01376 m
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
name: S-(2-Methylbutanoyl)-dihydrolipoamide
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28692
constant: false

metaM acald e
is: HMDB00990
has only substance units: false
boundary condition: false
name: acetaldehyde
is: SBO:0000247
is: CHEBI:15343
type: Species
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial amount: NaN
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_9b95799f_dd36_48b6_9c72_da5c8aee7598
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:AGPAT7
type: Species
name: _AGPAT7_1_c
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_3a285e90_18ee_4554_8e8e_ac90aac45ea8
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: MUT
boundary condition: true
is: P22033
is encoded by: hsa:4594

http://identifiers.org/biomodels.db/MODEL1310110011#_cbcf451f_e9bc_4b66_b3d5_6f2c0dc6087e
name: _AW299740_1_m
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AW299740
initial amount: NaN
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_edc4660c_812b_4e31_b152_6cdff69c284a
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:197257
initial amount: NaN
has only substance units: false
name: LDHD

http://identifiers.org/biomodels.db/MODEL1310110011#_c391a068_fb15_4d19_bf8c_cab4c0f0bfe1
type: Species
has only substance units: false
constant: false
name: GALK2
is encoded by: hsa:2585
is: Q01415
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_d74f25f0_7e0f_4ed9_a83f_74b5928019a1
is encoded by: hsa:6520
initial amount: NaN
constant: false
is encoded by: hsa:56301
type: Species
is: SBO:0000297
has only substance units: false
initial concentration: NaN
name: SLC7A10:SLC3A2
has part: P08195
has part: Q9NS82
boundary condition: true

metaM arachd x
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
is: HMDB01043
is: CHEBI:32395
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
name: arachidonate

metaM coa x
initial concentration: 1.0
is: CHEBI:57287
name: Coenzyme A
initial amount: NaN
is: C00010
type: Species
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: SBO:0000247
is: HMDB01423
boundary condition: false
constant: false

metaM cgly c
constant: false
boundary condition: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB00078
has only substance units: false
is: CHEBI:4047
name: L-cysteinylglycine
is: SBO:0000247

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaM CE5119 m
is: CHEBI:12947
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
has only substance units: false
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
name: trans-3-cis-8-tetradecadienoyl-CoA

metaM adp x
is: HMDB01341
has only substance units: false
constant: false
initial amount: NaN
name: ADP(3-)
is: SBO:0000247
is: CHEBI:456216
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
boundary condition: false
initial concentration: 1.0
type: Species

metaR ADRNt
fast: false
is: SBO:0000185
name: fatty acid transport via diffusion
is described by: ECO:0000000
reversible: true
product: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
reactant: MODEL1310110011#

metaM b2coa m
type: Species
initial concentration: 1.0
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
boundary condition: false
name: crotonoyl-CoA(4-)
is: HMDB02009
is: CHEBI:57332
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaM ptdcacrn c
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:15811
boundary condition: false
name: pendtadenoyl carnitine
is: HMDB01721
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1

metaR ACHEe
is described by: ECO:0000269
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.1.1.7
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
modifier: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
name: Acetylcholinesterase
type: Reaction

metaM tettet6coa c
is: SBO:0000247
is: HMDB06516
initial concentration: 1.0
constant: false
name: tetracosatetraenoyl coenzyme A
boundary condition: false
is: C16171
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
is: http://identifiers.org/pubchem.compound/47205481

http://identifiers.org/biomodels.db/MODEL1310110011#_1601aeca_6a8c_4a9d_8d49_2f123753b0e3
constant: false
has only substance units: false
is encoded by: hsa:51109
type: Species
is: B4DDW0
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: RDH11

http://identifiers.org/biomodels.db/MODEL1310110011#_2c5e38cd_930f_41d0_a7a2_0f3eee33c1ee
constant: false
is encoded by: hsa:AI924226
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
name: _AI924226_1_m
is: SBO:0000252
has only substance units: false

metaR r2521
reversible: true
fast: false
kinetic law: MODEL1310110011#
name: Utilized transport
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
reactant: MODEL1310110011#
type: Reaction
product: MODEL1310110011#

metaM lnlccoa m
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5462164
initial amount: NaN
has only substance units: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
name: linoleic coenzyme A
initial concentration: 1.0
is: HMDB01064
type: Species
constant: false

metaM ksi e
boundary condition: false
is: HMDB00211
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:17268
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: SBO:0000247
type: Species
name: keratan sulfate I

http://identifiers.org/biomodels.db/MODEL1310110011#_95072d61_22a3_49bf_94f3_4f044e3fff69
constant: false
is encoded by: hsa:131669
initial amount: NaN
name: UROC1
is: SBO:0000252
boundary condition: true
type: Species
is: Q68CJ7
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_efcbd808_dd97_418d_8136_4c7ff6a8731c
boundary condition: true
name: ACOT7
initial amount: NaN
is encoded by: hsa:11332
constant: false
initial concentration: NaN
is: O00154
has only substance units: false
is: SBO:0000252
type: Species

metaR r0801
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
is: SBO:0000185
fast: false
modifier: MODEL1310110011#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
reversible: true
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
product: MODEL1310110011#
reactant: MODEL1310110011#

metaR LEUKTRD4t
name: leukotriene D4 transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000269

metaR FAOXC16DCr
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

metaR C5DCe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of glutaryl carnitine into the extra cellular fluid
type: Reaction

metaR r0647
is described by: ECO:0000000
kinetic law: MODEL1310110011#
is: SBO:0000176
reactant: MODEL1310110011#
name: Spontaneous reaction
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
fast: false
reversible: true
product: MODEL1310110011#

metaM idp e
constant: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
boundary condition: false
initial amount: NaN
is: CHEBI:58280
type: Species
is: HMDB03335
name: IDP(3-)
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR GLNtN1
is described by: ECO:0000269
name: Glutamine transport (Na, H coupled)
product: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaM od2coa c
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:50570
is: SBO:0000247
is: HMDB06529
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244
name: trans-Octadec-2-enoyl-CoA
constant: false
is: C16218
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_3f7d6202_5d49_4cdf_b6d5_1518425d7fa1
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
name: ACSS3
is encoded by: hsa:79611
has only substance units: false
is: Q9H6R3
initial concentration: NaN

metaR CHOLATEt
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
reversible: true
kinetic law: MODEL1310110011#
is: SBO:0000185
reactant: MODEL1310110011#
name: cholate transport via bicarbonate countertransport
modifier: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000269
fast: false
type: Reaction

metaR HISCAT1
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaR ITCOAL1m
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
reactant: MODEL1310110011#
product: MODEL1310110011#
reversible: true
is: SBO:0000176
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/6.2.1.4
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
fast: false
is described by: ECO:0000304
type: Reaction

metaR GFUCS
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.271
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: NOTES:Both human and Escherichia coli enzymes can use NADH in place of NADPH to a slight extent. IT
is described by: ECO:0000000
reactant: MODEL1310110011#
type: Reaction
product: MODEL1310110011#
reversible: false
fast: false
modifier: MODEL1310110011#
name: GDP-L-fucose synthase

metaM 3hdececrn c
has only substance units: false
notes: FORMULA: C23H43NO5 CHARGE: 0
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: 3-hydroxyhexadecenoylcarnitine
boundary condition: false
is: HMDB02014
initial amount: NaN

metaM gal c
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0
initial concentration: 1.0
is: CHEBI:0
constant: false
type: Species
is: HMDB00143
initial amount: NaN
is: C00124
is: SBO:0000247
boundary condition: false
name: D-Galactose

metaM idp c
initial amount: NaN
name: IDP(3-)
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: HMDB03335
is: CHEBI:58280
boundary condition: false
constant: false

metaM ksi pre20 g
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
boundary condition: false
has only substance units: false
type: Species
name: keratan sulfate I biosynthesis, precursor 20
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:28067

metaR NDPK7n
fast: false
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: true
reactant: MODEL1310110011#
type: Reaction
is described by: ECO:0000304
is: SBO:0000176
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus

http://identifiers.org/biomodels.db/MODEL1310110011#_69cb939d_4b73_4bc0_8080_15edb758a42a
has only substance units: false
name: AMPD2
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is: B2RB47
type: Species
is encoded by: hsa:271
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_7ab29601_dfa8_488e_a6ea_527f1899d7fa
initial concentration: NaN
type: Species
initial amount: NaN
name: _AI373818_1_m
is: SBO:0000252
is encoded by: hsa:AI373818
constant: false
boundary condition: true
has only substance units: false

metaR LTD4DP
name: Leukotriene D4 dipeptidase
product: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110011#
reversible: true

metaR r0641
reversible: true
is described by: ECO:0000000
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
reactant: MODEL1310110011#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.1.2.4
product: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR ATP2ter
kinetic law: MODEL1310110011#
type: Reaction
fast: false
name: AMP/ATP transporter, endoplasmic reticulum
is: SBO:0000185
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
product: MODEL1310110011#
is described by: ECO:0000000

metaR GGH 6DHFe
modifier: MODEL1310110011#
product: MODEL1310110011#
reversible: false
kinetic law: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (6DHF), extracellular
reactant: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

metaR r1292
product: MODEL1310110011#
type: Reaction
fast: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000185
name: Postulated transport reaction
is described by: ECO:0000000
reversible: true

metaM coucoa m
constant: false
type: Species
is: CHEBI:57355
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C00223
name: 4-coumaroyl-CoA(4-)
notes: FORMULA: C30H38N7O18P3S1 CHARGE: -4 INCHI: InChI=1S/C30H42N7O18P3S/c1-30(2,25(42)28(43)33-10-9-20(39)32-11-12-59-21(40)8-5-17-3-6-18(38)7-4-17)14-52-58(49,50)55-57(47,48)51-13-19-24(54-56(44,45)46)23(41)29(53-19)37-16-36-22-26(31)34-15-35-27(22)37/h3-8,15-16,19,23-25,29,38,41-42H,9-14H2,1-2H3,(H,32,39)(H,33,43)(H,47,48)(H,49,50)(H2,31,34,35)(H2,44,45,46)/p-4/t19-,23-,24-,25+,29-/m1/s1

metaR r2526
reactant: MODEL1310110011#
product: MODEL1310110011#
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaR r0642
is: SBO:0000176
kinetic law: MODEL1310110011#
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
reactant: MODEL1310110011#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
reversible: true
product: MODEL1310110011#
is described by: ECO:0000000

metaR UPPN
fast: false
modifier: MODEL1310110011#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
is version of: http://identifiers.org/ec-code/3.5.1.6
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
name: b-ureidopropionase
reversible: false

metaR RE1845C
fast: false
is: SBO:0000176
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110011#
name: RE1845
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: true
product: MODEL1310110011#

metaR ENGASE2ly
product: MODEL1310110011#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
name: endo-beta-N-acetylglucosaminidase, lysosomal
fast: false
is: SBO:0000176

metaR EX tetdec2crn
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecadienoyl carnitine
type: Reaction

metaM acald c
boundary condition: false
has only substance units: false
constant: false
is: HMDB00990
is: SBO:0000247
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
name: acetaldehyde
is: CHEBI:15343
initial concentration: 1.0
type: Species
initial amount: NaN

metaM 3htdcoa m
constant: false
type: Species
is: HMDB02288
boundary condition: false
has only substance units: false
is: SBO:0000247
name: (S)-3-Hydroxytetradecanoyl-CoA
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0

metaM gal e
boundary condition: false
name: D-Galactose
is: CHEBI:0
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0
constant: false
is: HMDB00143
initial amount: NaN
type: Species
is: C00124
is: SBO:0000247

metaM 4mop m
is: SBO:0000247
name: 4-methyl-2-oxopentanoate
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:17865
boundary condition: false
is: HMDB00695

metaR r2525
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110011#

metaR PSt3
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
reversible: true
name: phosphatidylserine transport
product: MODEL1310110011#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110011#
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_fbd8b43d_c830_4aa7_a2b3_4e7803962e0b
initial amount: NaN
name: MAN2A2
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:4122
is: Q9P1E4
initial concentration: NaN
type: Species

metaM hyptaur c
initial amount: NaN
has only substance units: false
name: Hypotaurine
is: SBO:0000247
constant: false
is: CHEBI:16668
type: Species
boundary condition: false
is: HMDB00965
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
initial concentration: 1.0

metaR DNDPt28m
fast: false
modifier: MODEL1310110011#
reversible: false
kinetic law: MODEL1310110011#
name: dCDP transport via dGDP antiport
type: Reaction
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110011#_2e172b16_c821_4b2b_b95e_6ab99dc60d87
initial amount: NaN
is encoded by: hsa:205
has only substance units: false
type: Species
name: AK4
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR r0797
product: MODEL1310110011#
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: glycine N-choloyltransferase EC:2.3.1.65
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
reversible: true

metaM coa n
is: HMDB01423
is: CHEBI:57287
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
constant: false
name: coenzyme A(4-)
type: Species
boundary condition: false

metaR RE1532M
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110011#
is: SBO:0000176
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1532
fast: false
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110011#_a88d6ee2_7394_4be8_a51c_35f31e01b8d6
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9194
boundary condition: true
is: Q8NEM3
has only substance units: false
initial concentration: NaN
type: Species
name: SLC16A7

metaR CYSTHRNaEx
product: MODEL1310110011#
is: SBO:0000185
type: Reaction
name: L-cysteine/L-threonine Na-dependent exchange (Cys-L in)
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
modifier: MODEL1310110011#
is described by: ECO:0000269
reactant: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_91f1467b_e57b_455c_bd1c_0537a261fcb1
initial concentration: NaN
has only substance units: false
name: SDHC
is: SBO:0000252
boundary condition: true
is: Q99643
is encoded by: hsa:6391
initial amount: NaN
constant: false
type: Species

metaM 3hexdcrn e
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C23H45NO5 CHARGE: 0
constant: false
is: HMDB13336
is: SBO:0000247
name: 3-hydroxyhexadecanoylcarnitine
has only substance units: false
initial concentration: 1.0

metaR H7ET2er
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.8.1
is: SBO:0000176
name: H7 phosphoethanolaminyl transferase, endoplasmic reticulum
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: false
fast: false
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (5281.1) and (54872.1) or (5281.2) and (54872.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15632136 NOTES:NCD
type: Reaction
product: MODEL1310110011#

metaM acmanap c
is: CHEBI:58557
has only substance units: false
boundary condition: false
name: N-acetyl-D-mannosamine 6-phosphate(2-)
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H2,15,16,17)/p-2 HEPATONET_1.0_ABBREVIATION: HC01257 EHMN_ABBREVIATION: C04257
type: Species
is: HMDB01121
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_4970b620_3046_4f3b_a5c1_ac0e98289d3f
name: GGT1
is: SBO:0000252
is encoded by: hsa:2678
initial concentration: NaN
type: Species
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_9d6efc3a_a5fc_4132_8ebb_6b9d7e0945d1
is: P14618
has only substance units: false
is: SBO:0000252
name: PKM2
constant: false
boundary condition: true
type: Species
is encoded by: hsa:5315
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_15eb3676_bc7e_4012_9ccc_be83c2731057
is: SBO:0000252
is encoded by: hsa:10840
boundary condition: true
type: Species
name: ALDH1L1
is: O75891
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_5ce0f61c_7715_4d9c_9c03_d9cd8506f9a0
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P30838
is encoded by: hsa:218
name: ALDH3A1
type: Species
constant: false

metaM acald m
name: acetaldehyde
type: Species
is: CHEBI:15343
initial amount: NaN
is: HMDB00990
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_af1b8ffd_7d79_46fd_9864_f8b0294b3818
type: Species
name: RRM2
initial concentration: NaN
has only substance units: false
is: P31350
initial amount: NaN
is encoded by: hsa:6241
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_702c6d68_42f6_418b_9e27_88adf8eca1d6
is encoded by: hsa:221
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: P43353
initial concentration: NaN
constant: false
name: ALDH3B1
boundary condition: true
type: Species

metaR r1291
type: Reaction
reversible: true
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: Postulated transport reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_c21b3b85_12db_4f72_a429_59a574cefd59
boundary condition: true
initial amount: NaN
is: O75106
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:314
name: AOC2
type: Species
constant: false
has only substance units: false

metaM 3hexdcrn c
is: HMDB13336
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
name: 3-hydroxyhexadecanoylcarnitine
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C23H45NO5 CHARGE: 0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_9680ae2f_7b99_4fea_8323_b452a6094bad
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: UPB1
is: B3KNC1
initial concentration: NaN
constant: false
is encoded by: hsa:51733
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_074f34a7_ffd8_41b8_8a19_437b345b791f
initial amount: NaN
has only substance units: false
type: Species
has part: O43924
is encoded by: hsa:5147
constant: false
has part: P18545
initial concentration: NaN
name: PDE6A:PDE6C:PDE6D:PDE6G:PDE6B
is encoded by: hsa:5148
is: SBO:0000297
boundary condition: true

metaR r0226
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
is described by: ECO:0000000
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
type: Reaction
reversible: false
modifier: MODEL1310110011#
is: SBO:0000176
fast: false
product: MODEL1310110011#
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_f3816f2b_5fb9_4b60_8c51_2d7009685799
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q99643
name: SDHC
is encoded by: hsa:6391
initial amount: NaN
boundary condition: true

metaR DGSNt
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
name: deoyguanosine transport via diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110011#

metaR r0393
reactant: MODEL1310110011#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.74
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
product: MODEL1310110011#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_8db45c81_9fbb_4e4d_81ea_e246534cbc98
constant: false
initial concentration: NaN
is encoded by: hsa:276
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
name: AMY1A
is: Q6NSB3
is: SBO:0000252

metaM pmtcoa x
has only substance units: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
type: Species
is: SBO:0000247
boundary condition: false
is: C00154
constant: false
is: HMDB01338
name: Palmitoyl-CoA (n-C16:0CoA)
is: CHEBI:57379
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_4082a4cf_f402_4a71_a31f_1de10ab8826d
name: PAFAH1B2
is encoded by: hsa:5049
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
is: A8DPS7

metaM orn e
initial amount: NaN
boundary condition: false
is: HMDB00214
is: SBO:0000247
type: Species
name: Ornithine
notes: FORMULA: C5H13N2O2 CHARGE: 1
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:0
is: C01602

http://identifiers.org/biomodels.db/MODEL1310110011#_e1ea13fc_87a1_4618_a9c9_f0ae60cd87d2
is encoded by: hsa:80308
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
name: FLAD1
initial amount: NaN
is: SBO:0000252

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaR S6T8g
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110011#
reactant: MODEL1310110011#
product: MODEL1310110011#
fast: false

metaM ksii core2 pre1 g
constant: false
type: Species
notes: FORMULA: C33H53N3O23X CHARGE: -1
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28067
is: SBO:0000247
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 1

http://identifiers.org/biomodels.db/MODEL1310110011#_4fbbddad_7bd0_426c_acf1_9d71aa54584b
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q8IXW6
type: Species
name: DPYSL3
boundary condition: true
initial amount: NaN
is encoded by: hsa:1809

http://identifiers.org/biomodels.db/MODEL1310110011#_4b13a058_bc6a_49bf_956a_f9700c1da861
is: SBO:0000252
name: PDE8A
is encoded by: hsa:5151
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
has only substance units: false

metaM ipdp x
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
initial amount: NaN
constant: false
name: isopentenyl diphosphate(3-)
has only substance units: false
type: Species
is: CHEBI:128769
is: SBO:0000247
initial concentration: 1.0
is: HMDB01347
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_878d7062_c889_4a31_b956_6cbaad7edd05
boundary condition: true
name: HPGDS
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:27306
is: O60760
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_c91cca00_31fb_457d_b80d_b11818bc9e2d
type: Species
is: SBO:0000252
initial amount: NaN
is: Q9P019
name: PHPT1
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:29085
constant: false

metaR GLU5Km
reversible: false
reactant: MODEL1310110011#
is: SBO:0000176
kinetic law: MODEL1310110011#
name: glutamate 5-kinase (m)
type: Reaction
product: MODEL1310110011#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 2.7.2.11 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m
fast: false
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.2.1.41

metaM sphs1p r
constant: false
is: CHEBI:60119
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: sphingosine 1-phosphate(1-)
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
boundary condition: false
has only substance units: false
is: HMDB00277

metaR r0394
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110011#
reversible: true
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110011#
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_db42ec8b_8bd9_4003_9012_157802c55f62
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial concentration: NaN
name: DGKB
is encoded by: hsa:1607

http://identifiers.org/biomodels.db/MODEL1310110011#_0176c0e6_9da4_490a_bf6e_239196f0c34d
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
name: HK1
is: P19367
constant: false
is encoded by: hsa:3098
initial amount: NaN

metaR r0399
product: MODEL1310110011#
modifier: MODEL1310110011#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
kinetic law: MODEL1310110011#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.2
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000

metaR DNDPt9m
fast: false
reversible: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110011#
is described by: ECO:0000269
modifier: MODEL1310110011#
name: dADP transport via dTDP antiport
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#

metaR G5SDym
reactant: MODEL1310110011#
name: glutamate-5-semialdehyde dehydrogenase (m)
is described by: ECO:0000254
modifier: MODEL1310110011#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 1.2.1.41 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m TDV: name change from G5SDm
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.2.1.41
fast: false
reversible: false
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_6cda5e09_480e_4e4a_aee0_7e639677b086
name: PGAP1
initial amount: NaN
is: Q75T13
is: SBO:0000252
boundary condition: true
is encoded by: hsa:80055
initial concentration: NaN
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_91edefed_322d_4060_aa8d_dbc954e15e2e
type: Species
name: SCD5
is: Q86SK9
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:79966

metaM q10 c
is: CHEBI:46245
name: ubiquinone-10
has only substance units: false
is: HMDB01072
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
boundary condition: false
constant: false
is: SBO:0000247

metaM orn c
boundary condition: false
is: CHEBI:0
initial amount: NaN
initial concentration: 1.0
is: HMDB00214
is: SBO:0000247
notes: FORMULA: C5H13N2O2 CHARGE: 1
name: Ornithine
has only substance units: false
type: Species
constant: false
is: C01602

http://identifiers.org/biomodels.db/MODEL1310110011#_38a00449_f675_4175_8563_6e385014a979
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q13057
has only substance units: false
is encoded by: hsa:80347
constant: false
name: COASY
initial concentration: NaN

metaM ethamp r
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:58190
is: HMDB00224
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
name: O-phosphonatoethanaminium(1-)

http://identifiers.org/biomodels.db/MODEL1310110011#_d0ef7da6_fa3d_4872_b98a_c206d032ce1d
has only substance units: false
is encoded by: hsa:AA614647
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: _AA614647_1_c

metaR THRCYSNaEx
reversible: false
product: MODEL1310110011#
fast: false
name: L-cysteine/L-threonine Na-dependent exchange (Thr-L in)
reactant: MODEL1310110011#
is: SBO:0000185
kinetic law: MODEL1310110011#
is described by: ECO:0000269
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction

metaM coa r
initial amount: NaN
has only substance units: false
is: CHEBI:57287
is: C00010
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
name: Coenzyme A
constant: false
is: HMDB01423
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_b2f972cb_df2a_43b0_9907_6a1ba6ac9e7c
is: P48728
boundary condition: true
constant: false
is: SBO:0000252
name: AMT
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:275
type: Species

metaR MAL Lte
kinetic law: MODEL1310110011#
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110011#
is described by: ECO:0000134
reversible: true
name: Transport of L-malate

metaM gam6p c
initial concentration: 1.0
is: HMDB01254
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
type: Species
name: D-Glucosamine 6-phosphate
is: CHEBI:12962
is: SBO:0000247

metaM 3htdcoa c
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
constant: false
name: (S)-3-Hydroxytetradecanoyl-CoA
boundary condition: false
has only substance units: false
is: HMDB02014
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species

metaR UDPGLCAter
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
is described by: ECO:0000269
fast: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000185
modifier: MODEL1310110011#
product: MODEL1310110011#
name: UDPGlcA endoplasmic reticulum transport via UMP antiport

metaM dpcoa c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: CHEBI:57328
constant: false
has only substance units: false
is: HMDB01373
boundary condition: false
name: Dephospho-CoA
type: Species
is: C00882

MODEL1310110011#
species: metaM 10fthf c
species: metaM HC01609 e
species: metaM elaid e
species: metaM c226crn c
species: metaM dudp c
species: metaM 4abutn c
species: metaM glc D c
species: metaM vacc e
species: metaM 10fthf e
species: metaM HC01377 m
species: metaM leugly e
species: metaM leuktrC4 e
species: metaM bamppald c
species: metaM dump m
species: metaM HC02205 c
species: metaM 3hddcoa c
species: metaM HC02204 e
species: metaM pi m
species: metaM HC01712 m
stoichiometry: 0.392525
species: metaM acgam6p c
species: metaM fmn e
species: metaM 2dodtricoa m
species: metaM arachdcoa r
species: metaM strdnccoa c
stoichiometry: 0.385872
species: metaM arachdcoa c
species: metaM dha e
species: metaM dcsptn1coa c
species: metaM uri e
species: metaM eicostet c
species: metaM o2 x
species: metaM ocdececrn m
species: metaM dhf c
species: metaM ura c
species: metaM dlnlcgcoa c
species: metaM gdp m
species: metaM prostgf2 c
species: metaM dgchol x
species: metaM dece4coa m
species: metaM adrncoa c
species: metaM stcoa m
species: metaM nadh x
species: metaM ribflv c
species: metaM damp c
species: metaM hestratriol e
species: metaM HC01401 m
species: metaM h2o e
species: metaM arg L c
species: metaM hdcoa c
species: metaM HC01434 x
species: metaM m7mpdol L r
species: metaM cdp n
species: metaM glyb c
species: metaM HC02206 e
name: GUCY1B2:GUCY1A2
species: metaM HC00695 m
species: metaM man6p c
species: metaM man g
species: metaM fum m
species: metaM CE5854 e
species: metaM 2docohexecoa m
species: metaM ksi pre23 g
species: metaM lnlnca c
species: metaM 7dhf e
species: metaM crn m
species: metaM ctp e
name: HEXA:HEXB
species: metaM lnlnca e
species: metaM m2mn l
species: metaM malttr e
species: metaM dectricoa m
species: metaM HC02204 c
species: metaM fmn c
species: metaM 3hddcoa m
species: metaM gthrd e
species: metaM sql r
species: metaM h c
species: metaM 3hodcoa m
species: metaM 3dodtricoa m

http://identifiers.org/biomodels.db/MODEL1310110011#_4895a599_7c5e_44d9_b100_2988dadb1651
type: Species
is: Q56NI9
initial concentration: NaN
name: ESCO2
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:157570
has only substance units: false

metaR O16G2e
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: NOTES:NCD
name: oligo-1,6-glucosidase (strch2 ->strch3), extracellular
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
reversible: false
fast: false
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.2.1.10
type: Reaction

metaR FAOXC1811601m
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
reactant: MODEL1310110011#
fast: false
product: MODEL1310110011#
reversible: false
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110011#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_495e6882_6add_4ae7_88b2_81228dc23d53
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
name: NME7
is encoded by: hsa:29922
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_c51c8ae8_f03e_42b3_a05f_f3c1bb5984b7
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:5152
has only substance units: false
initial amount: NaN
name: PDE9A

http://identifiers.org/biomodels.db/MODEL1310110011#_979a4127_574c_455c_8484_dbe98dedc914
type: Species
is encoded by: hsa:6550
is: P48764
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
name: SLC9A3
initial concentration: NaN
is: SBO:0000252

metaR EX gdp LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GDP exchange
type: Reaction

metaM ksi g
type: Species
is: CHEBI:17140
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I
boundary condition: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: HMDB01644

metaR XYLTt
reversible: true
name: Xylitol transport via passive diffusion
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000000
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
fast: false
is: SBO:0000185
type: Reaction

metaR ESTRADIOLt
kinetic law: MODEL1310110011#
type: Reaction
product: MODEL1310110011#
name: estradiol transport
reactant: MODEL1310110011#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR FAOXC162C162OHm
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:2-->C16:2OH)m
type: Reaction

metaR GLYCLTtp
fast: false
reversible: false
product: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
reactant: MODEL1310110011#
name: glycolate transport into peroxisome
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110011#

metaM T4hcinnm m
name: trans-4-coumarate
initial concentration: 1.0
constant: false
is: CHEBI:12876
has only substance units: false
boundary condition: false
type: Species
is: HMDB02035
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H7O3 CHARGE: -1 INCHI: InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/p-1/b6-3+ EHMN_ABBREVIATION: C00811

http://identifiers.org/biomodels.db/MODEL1310110011#_3300dbf5_908b_4dfc_a43f_7d7dc92e89ab
is: Q16774
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:2987
name: GUK1
constant: false
initial amount: NaN

metaM m2mpdol L c
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:28049
constant: false
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C1420H2328N20O320P20 CHARGE: -20

metaR DPMVDx
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.1.33 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
product: MODEL1310110011#
modifier: MODEL1310110011#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.33
name: diphosphomevalonate decarboxylase
kinetic law: MODEL1310110011#
fast: false
is: SBO:0000176
is described by: ECO:0000134

metaM dd5ecoa m
type: Species
boundary condition: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
has only substance units: false
is: HMDB13028
name: 5-dodecenoylcoa
is: C01942
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR r2029
reversible: false
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000185
reactant: MODEL1310110011#
type: Reaction
product: MODEL1310110011#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaM stcrn m
is: HMDB00848
is: SBO:0000247
name: stearoylcarnitine
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaM adn c
boundary condition: false
constant: false
is: HMDB00050
has only substance units: false
name: Adenosine
is: C00212
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: CHEBI:16335
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_420a0aaa_16c5_491a_9749_af72a40d07fb
constant: false
is: SBO:0000252
is: P19961
boundary condition: true
initial concentration: NaN
type: Species
name: AMY2B
has only substance units: false
is encoded by: hsa:280
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_b80fe40a_834a_4d8b_8edf_19d3964b14f2
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
name: GLRX2
is: Q9NS18
type: Species
is encoded by: hsa:51022
initial amount: NaN

metaR TMNDNCCRNt
kinetic law: MODEL1310110011#
product: MODEL1310110011#
name: transport into the mitochondria (carnitine)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110011#
fast: false
reversible: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110011#

metaR r2028
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
kinetic law: MODEL1310110011#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000000
modifier: MODEL1310110011#

metaR MM7Cbg
is version of: http://identifiers.org/ec-code/3.2.1.113
product: MODEL1310110011#
modifier: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
reactant: MODEL1310110011#
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110011#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus

metaR LTC4Sr
product: MODEL1310110011#
fast: false
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (4056.1) or (4259.1) or (4056.2) or (4258.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 4.4.1.20 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:previous EC 2.5.1.37 EC: 4.4.1.20 NJ
type: Reaction
is version of: http://identifiers.org/ec-code/4.4.1.20
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
name: Leukotriene C4 synthase
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.5.1.18
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110011#_c7dfa588_3d28_48fb_8be2_b1838d62ecf0
name: ACAD9
has only substance units: false
initial concentration: NaN
is encoded by: hsa:28976
is: Q9H845
boundary condition: true
initial amount: NaN
constant: false
type: Species
is: SBO:0000252

metaR CYTK8n
is described by: ECO:0000269
type: Reaction
fast: false
product: MODEL1310110011#
reversible: true
is: SBO:0000176
name: cytidylate kinase (CMP,dATP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_f864b831_0d4a_448d_ae59_ab80b823aeab
initial amount: NaN
name: NDUFB7
constant: false
is: P17568
is encoded by: hsa:4713
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR 5OXPROt
reactant: MODEL1310110011#
is described by: ECO:0000134
kinetic law: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
reversible: true
name: Transport of 5-oxoprolinate
product: MODEL1310110011#
is: SBO:0000185

metaM ksi pre17 g
name: keratan sulfate I biosynthesis, precursor 17
type: Species
is: SBO:0000247
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
has only substance units: false
is: CHEBI:28067
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false

metaM Lkynr c
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00684
name: L-kynurenine
constant: false
type: Species
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
is: CHEBI:16946
has only substance units: false

metaM stcrn c
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00848
initial amount: NaN
type: Species
name: stearoylcarnitine

http://identifiers.org/biomodels.db/MODEL1310110011#_b0171bb6_d049_4c34_be8a_8b333d65f486
boundary condition: true
has only substance units: false
is: P06744
is encoded by: hsa:2821
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
name: GPI

metaM CE2432 m
is: http://identifiers.org/pubchem.compound/5041
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
type: Species
constant: false
is: SBO:0000247
is: C01936
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM eitetcoa m
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB06294
constant: false
name: 5,8,11,14-eicosatetraenoylcoa
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species

metaR EX hexc LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexacosanoate (n-C26:0) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_0f7da3c0_cfd7_4de8_bcfa_08261129e44a
has only substance units: false
name: IK
initial amount: NaN
type: Species
is: Q13123
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3550

metaM pmtcoa r
constant: false
type: Species
is: HMDB01338
is: C00154
initial concentration: 1.0
is: CHEBI:3454
name: Palmitoyl-CoA (n-C16:0CoA)
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
has only substance units: false

metaR r0911
type: Reaction
kinetic law: MODEL1310110011#
name: Facilitated diffusion
fast: false
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
reversible: true
reactant: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000185

metaM dtdp c
boundary condition: false
constant: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial concentration: 1.0
is: HMDB01274
type: Species
name: dTDP
is: CHEBI:58369
is: C00363
has only substance units: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_45c081ca_fa89_4523_840a_0afc6b6d6968
is encoded by: hsa:4695
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
name: NDUFA2
constant: false
is: O43678
type: Species
initial amount: NaN

metaM 6pgl r
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57955
constant: false
type: Species
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
is: SBO:0000247
is: HMDB01127
has only substance units: false
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_5895e178_5dcb_4cce_9505_c108279a2348
name: AMPD1
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:270
is: P23109
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false

metaM 1pyr5c m
name: 1-Pyrroline-5-carboxylate
is: HMDB01301
boundary condition: false
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
initial amount: NaN
is: CHEBI:15893
is: SBO:0000247
initial concentration: 1.0
is: C03912
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_e2b71a98_e731_41d3_b552_0f0ccebbd616
initial concentration: NaN
name: GGT5
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:2687
is: P36269
is: SBO:0000252

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_9f68a39b_5553_43d1_8f1a_ac28ea001386
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:7841
is: SBO:0000252
type: Species
boundary condition: true
name: MOGS
is: F5H6D0
has only substance units: false

metaM ile L m
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
has only substance units: false
is: CHEBI:17191
name: L-isoleucine
is: HMDB00172
type: Species
constant: false
initial concentration: 1.0

metaM CE0693 m
is: HMDB11123
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
is: CHEBI:28387
has only substance units: false
type: Species
is: SBO:0000247
name: 3-oxolaur-6-cis-enoyl-CoA

metaR FAOXC1811602m
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation fatty acid
is described by: ECO:0000000
product: MODEL1310110011#
reversible: false
kinetic law: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110011#
type: Reaction

metaR FERO
name: ferroxidase
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110011#
product: MODEL1310110011#
fast: false
reversible: false
reactant: MODEL1310110011#
is: SBO:0000176
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:

http://identifiers.org/biomodels.db/MODEL1310110011#_5d64aeb1_8146_4a98_ab46_a53d0ffe43f7
initial amount: NaN
has only substance units: false
is encoded by: hsa:211
is: SBO:0000252
constant: false
is: Q5JAM2
initial concentration: NaN
type: Species
boundary condition: true
name: ALAS1

http://identifiers.org/biomodels.db/MODEL1310110011#_13ea62cb_d6a5_4242_bd2e_3a4987312159
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:U52111
name: _U52111_1_c
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_05b150e9_34ac_43f4_8ae9_f5e24e9d1f5a
constant: false
is: SBO:0000252
is: Q01581
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:3157
name: HMGCS1
initial concentration: NaN
has only substance units: false

metaR r1608
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#
is: SBO:0000185
fast: false

metaR UDPGLCter
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
product: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110011#
reversible: true
reactant: MODEL1310110011#
is: SBO:0000185

metaR UMPK
product: MODEL1310110011#
name: UMP kinase
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110011#

metaM orn m
type: Species
initial concentration: 1.0
is: HMDB00214
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
name: Ornithine
is: CHEBI:46912
initial amount: NaN
is: C01602
notes: FORMULA: C5H13N2O2 CHARGE: 1

metaR r0913
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
product: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
kinetic law: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#

metaR PAPStg
is described by: ECO:0000269
fast: false
is: SBO:0000185
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
reversible: true
type: Reaction
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
name: 3'-Phosphoadenylyl sufate Golgi transport

http://identifiers.org/biomodels.db/MODEL1310110011#_42b23187_f597_41ef_80d3_3f7228dcf6bf
is: SBO:0000252
type: Species
has only substance units: false
constant: false
is encoded by: hsa:AA532636
initial amount: NaN
name: _AA532636_1_m
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_a6fdaff9_2ce3_4436_a9b1_9d6550812488
is: F8WDN9
name: PPA2
initial amount: NaN
is encoded by: hsa:27068
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false

metaR ASNALANaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-alanine/L-asparagine Na-dependent exchange (Asn-L in)
reversible: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#
modifier: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269

metaM od2coa m
name: trans-Octadec-2-enoyl-CoA
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB06529
initial concentration: 1.0
is: CHEBI:50570
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h18-19,26-28,32-34,38,49-50H,4-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b19-18+/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE2244
constant: false

metaR CYSGLTH
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
type: Reaction
kinetic law: MODEL1310110011#
name: Glutathione:cystine oxidoreductase
fast: false
reversible: true
reactant: MODEL1310110011#
is: SBO:0000176
product: MODEL1310110011#

metaR RE0453C
name: RE0453
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000176
type: Reaction

metaR FAOXC4C4DCc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: succ-->C4DCc
type: Reaction

metaM prostgi2 c
boundary condition: false
constant: false
is: CHEBI:57403
is: SBO:0000247
type: Species
is: HMDB01335
name: prostaglandin I2(1-)
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_260bdc37_7f2b_49a1_91c2_352f979b01b3
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:131
constant: false
is: SBO:0000252
is: P40394
initial amount: NaN
name: ADH7
has only substance units: false

metaR r1609
kinetic law: MODEL1310110011#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110011#
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_77a65030_1a51_466f_ab6f_ff514068ea64
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: KHK
type: Species
is encoded by: hsa:3795
initial concentration: NaN
is: Q6IBK2
has only substance units: false

metaM HC01842 c
boundary condition: false
initial concentration: 1.0
name: Phosphodimethylethanolamine
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
is: CHEBI:31997
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_57ff0dea_669b_4472_8d12_46c2160403fa
has only substance units: false
name: SKIV2L2
boundary condition: true
is encoded by: hsa:23517
type: Species
is: Q3MHC9
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN

metaR MANtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: mannose efflux from Golgi apparatus
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110011#
type: Reaction
reversible: false
fast: false
product: MODEL1310110011#
kinetic law: MODEL1310110011#

metaM HC01444 e
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
is: SBO:0000247
initial concentration: 1.0
type: Species
name: Galactosylglycerol
constant: false
is: CHEBI:15754

metaR EX HC00822 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chitobiose exchange
type: Reaction

metaM ivcrn c
name: isovaleryl carnitine
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C12H23NO4 CHARGE: 0
boundary condition: false
is: SBO:0000247
is: HMDB00688
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_0abe19d9_58b4_44b8_967e_af98b49b7845
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: O43916
name: CHST1
has only substance units: false
is encoded by: hsa:8534
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_7088c7cd_a5d9_4ffc_a4b8_6765da0623f7
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: NME1:NME2
boundary condition: true
is encoded by: hsa:4831
initial concentration: NaN
has part: P15531
is encoded by: hsa:4830
is: SBO:0000297
has part: P22392

metaM glyb c
has only substance units: false
is: CHEBI:17750
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: HMDB00043
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
name: glycine betaine

metaR r0392
is: SBO:0000176
fast: false
kinetic law: MODEL1310110011#
reversible: true
product: MODEL1310110011#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
reactant: MODEL1310110011#
is described by: ECO:0000000
type: Reaction

metaM lnlncacrn c
boundary condition: false
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
is: HMDB06319
constant: false
has only substance units: false
initial concentration: 1.0
name: alpha-linolenyl carnitine
is: SBO:0000247
initial amount: NaN
type: Species

metaR r1466
kinetic law: MODEL1310110011#
reversible: true
product: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110011#
is: SBO:0000176
name: EC:2.3.1.86

metaR r1606
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#
is described by: ECO:0000000
reactant: MODEL1310110011#
reversible: true
fast: false

metaR GCHOLAtx
reversible: true
name: bile acid intracellular transport
kinetic law: MODEL1310110011#
is described by: ECO:0000000
fast: false
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110011#
type: Reaction
is: SBO:0000185

metaR 3MOPte
is described by: ECO:0000134
reactant: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
fast: false
reversible: true
name: Transport of 3-methyl-2-oxopentanoate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110011#

metaM prostgi2 e
name: prostaglandin I2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
constant: false
is: HMDB01335
has only substance units: false
initial concentration: 1.0
is: CHEBI:57403
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247

metaR FAOXC226m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

metaR r0915
type: Reaction
kinetic law: MODEL1310110011#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
is: SBO:0000185
product: MODEL1310110011#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110011#_e2c89320_512b_4355_b4ab_f16b6f12bea5
is: P24752
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:38
has only substance units: false
name: ACAT1
type: Species
initial concentration: NaN
initial amount: NaN

metaM tettet6 e
constant: false
initial amount: NaN
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
is: HMDB06246
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
name: tetracosatetraenoic acid n-6
initial concentration: 1.0

metaM adp n
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB01341
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
name: ADP(3-)
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:456216

http://identifiers.org/biomodels.db/MODEL1310110011#_f62f8077_7057_44b6_ad1b_809a2bbbdef5
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: ALG8
boundary condition: true
type: Species
is: Q9BVK2
has only substance units: false
constant: false
is encoded by: hsa:79053

metaR G14T11g
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
reversible: false
modifier: MODEL1310110011#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110011#

metaR HISt4
notes: GENE_ASSOCIATION: (11254.1) or (54407.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10930503 NOTES:SAB
modifier: MODEL1310110011#
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000269
fast: false
reversible: false
is: SBO:0000185
type: Reaction
name: L-histidine transport in via sodium symport
product: MODEL1310110011#

metaM HC01415 m
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:27537
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
name: (2E)-Octenoyl-CoA

metaR r1467
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110011#
product: MODEL1310110011#
name: Postulated transport reaction
fast: false
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110011#_168bc3b4_512e_4343_b7f1_1da881076339
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:221
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P43353
name: ALDH3B1

metaM lnlccoa c
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5462164
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB01064
constant: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
type: Species
name: linoleic coenzyme A

metaR r1607
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
product: MODEL1310110011#
kinetic law: MODEL1310110011#

metaM 5thf e
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB06487
name: pentaglutamyl folate (THF)
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C39H45N11O18 CHARGE: -6

metaM r5p r
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
name: alpha-D-Ribose 5-phosphate
constant: false
is: HMDB00618
is: CHEBI:18189
has only substance units: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117

metaM glyb e
constant: false
is: SBO:0000247
name: glycine betaine
type: Species
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: CHEBI:17750
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00043
initial concentration: 1.0

metaR r0390
is described by: ECO:0000000
type: Reaction
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
product: MODEL1310110011#
is: SBO:0000176
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
reversible: true

metaM ivcrn e
constant: false
name: isovaleryl carnitine
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00688
notes: FORMULA: C12H23NO4 CHARGE: 0
boundary condition: false
type: Species
has only substance units: false

metaM adp m
name: ADP
is: HMDB01341
is: http://identifiers.org/pubchem.compound/3310
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:456216
constant: false
is: C00008

metaR C16DCc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexadecanedioylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_16e605c5_4677_489d_9a54_e58a94f3b274
is: SBO:0000252
is: Q16773
type: Species
initial concentration: NaN
name: CCBL1
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:883
initial amount: NaN

metaR r1604
is: SBO:0000185
reversible: true
product: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110011#

metaR r1148
kinetic law: MODEL1310110011#
is described by: ECO:0000000
reactant: MODEL1310110011#
fast: false
name: Active transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
is: SBO:0000185
product: MODEL1310110011#

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaM dmnoncrn x
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
name: 4,8-dimethylnonanoyl carnitine
constant: false
is: HMDB06202
notes: FORMULA: C18H37NO4 CHARGE: 0
boundary condition: false
initial concentration: 1.0

metaM C04849 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
boundary condition: false
is: CHEBI:57449
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_09cb6a87_5529_41d6_b198_1dc79f266cb4
name: GLDC
has only substance units: false
boundary condition: true
is encoded by: hsa:2731
initial amount: NaN
type: Species
is: P23378
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_0fe25a6a_36db_4a72_8f74_5cd298abdce4
has only substance units: false
constant: false
is: SBO:0000252
name: NPR2
initial amount: NaN
type: Species
initial concentration: NaN
is: P20594
boundary condition: true
is encoded by: hsa:4882

metaR RE1517M
reactant: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
kinetic law: MODEL1310110011#
is: SBO:0000176
reversible: true
name: RE1517
is version of: http://identifiers.org/ec-code/1.3.99.13
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
product: MODEL1310110011#

metaR r2021
reactant: MODEL1310110011#
reversible: false
product: MODEL1310110011#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110011#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110011#_c3d9b0ff_bd0e_4a31_998e_792ffbac3bcc
is: P49915
boundary condition: true
name: GMPS
is encoded by: hsa:8833
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_88edb204_0010_4d98_90a7_c420a93c1f75
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q5DSZ6
initial concentration: NaN
is encoded by: hsa:54576
constant: false
is: SBO:0000252
name: UGT1A8
type: Species

metaR DNDPt22m
fast: false
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000269
name: dTDP transport via dUDP antiport
type: Reaction
reversible: false
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
modifier: MODEL1310110011#

metaR r0917
reversible: true
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_c1fd31f2_026d_4433_9e58_cdd8be32a5fd
is: SBO:0000252
is encoded by: hsa:5052
name: PRDX1
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false

metaR r1147
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110011#
fast: false

metaR r1605
reversible: true
kinetic law: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110011#

metaM abt c
name: L-arabinitol
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:18403
is: HMDB01851
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaM decdicoa c
boundary condition: false
is: HMDB01168
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
name: decadienoylcoa

metaM dtdp e
has only substance units: false
is: HMDB01274
type: Species
boundary condition: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
initial concentration: 1.0
is: CHEBI:58369
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363

http://identifiers.org/biomodels.db/MODEL1310110011#_341f0576_f026_4fe6_a950_8b981308d07d
initial concentration: NaN
initial amount: NaN
name: SLC2A8
is encoded by: hsa:29988
type: Species
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q9NY64

metaM adp c
has only substance units: false
boundary condition: false
is: C00008
is: CHEBI:16761
name: ADP
type: Species
is: HMDB01341
is: http://identifiers.org/pubchem.compound/3310
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0

metaM 4mop c
has only substance units: false
name: 4-methyl-2-oxopentanoate
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
is: SBO:0000247
is: HMDB00695
type: Species
constant: false
initial amount: NaN
is: CHEBI:17865
boundary condition: false

metaM HC02187 e
is: SBO:0000247
initial concentration: 1.0
name: reverse-triiodthyronine
is: CHEBI:28774
type: Species
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
initial amount: NaN

metaM ile L c
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: CHEBI:17191
is: HMDB00172
has only substance units: false
name: L-isoleucine

metaM psylchol e
is: SBO:0000247
initial amount: NaN
is: HMDB03402
notes: FORMULA: C9642032H15428743NO8667420 CHARGE: 0
constant: false
name: psillium-glycocholic acid complex
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0

metaM pristcoa x
initial concentration: 1.0
type: Species
name: pristanoyl coa
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
is: SBO:0000247
has only substance units: false
is: CHEBI:51341

metaR r1602
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110011#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_d301843a_b478_42aa_9d1d_89c6410f73c3
has only substance units: false
type: Species
constant: false
name: _AA278423_1_c
initial amount: NaN
boundary condition: true
is encoded by: hsa:AA278423
initial concentration: NaN
is: SBO:0000252

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_1c9920a3_d37f_4fd6_8df9_d91b06e96ec7
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:223
has only substance units: false
type: Species
name: ALDH9A1
constant: false
boundary condition: true
is: P49189

metaM octa e
notes: FORMULA: C8H15O2 CHARGE: -1
initial amount: NaN
is: C06423
is: CHEBI:25646
name: octanoate (n-C8:0)
boundary condition: false
initial concentration: 1.0
is: HMDB00482
constant: false
is: SBO:0000247
has only substance units: false
type: Species

metaR ACACtx
reversible: true
name: acetoacetate intracellular transport unknown mechanism
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
reactant: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#
is: SBO:0000185
fast: false
product: MODEL1310110011#

metaR RE0453M
kinetic law: MODEL1310110011#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: true
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
name: RE0453

metaR SEBCOAPET
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

metaM idp n
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
boundary condition: false
initial concentration: 1.0
is: HMDB03335
type: Species
is: CHEBI:58280
name: IDP(3-)
is: SBO:0000247

metaR NDP7ex
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
reversible: false
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.6
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110011#
name: nucleoside-diphosphatase (UDP), extracellular

http://identifiers.org/biomodels.db/MODEL1310110011#_4bb2ade9_d4a0_4bda_87df_1254af455af1
is: SBO:0000252
name: _AA977580_1_c
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:AA977580

metaM mmcoa R m
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
is: CHEBI:57326
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB01269
is: SBO:0000247
initial concentration: 1.0
type: Species
name: (R)-methylmalonyl-CoA(5-)

metaR r2516
product: MODEL1310110011#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
reactant: MODEL1310110011#
reversible: true
kinetic law: MODEL1310110011#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM abt e
type: Species
is: CHEBI:18403
initial concentration: 1.0
initial amount: NaN
name: L-arabinitol
has only substance units: false
constant: false
is: HMDB01851
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532

metaR r1603
reversible: true
product: MODEL1310110011#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110011#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110011#

metaR C16DCe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexadecanedioic acid mono-L-carnitine ester into extra cellular space
type: Reaction

metaR FADH2ETC
is described by: ECO:0000134
reversible: false
name: Complex II reaction for respiratory chain
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
product: MODEL1310110011#
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_87ba1304_88ea_43cc_9076_10122f5750c1
initial amount: NaN
is: Q9BY32
is encoded by: hsa:3704
is: SBO:0000252
type: Species
constant: false
boundary condition: true
has only substance units: false
name: ITPA
initial concentration: NaN

metaR EX 34hpp
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_053b114e_8c57_4779_822d_6261a71df443
is encoded by: hsa:7001
constant: false
name: PRDX2
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P32119
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_dd0a647c_c9a5_4ebc_bc49_74f7047d0ea2
is: P11168
boundary condition: true
constant: false
initial amount: NaN
name: SLC2A2
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6514
has only substance units: false
type: Species

metaM ptdcacrn m
type: Species
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
initial concentration: 1.0
is: HMDB01721
name: pendtadenoyl carnitine
is: SBO:0000247
is: CHEBI:15811
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

metaM ile L e
name: L-isoleucine
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:17191
is: HMDB00172
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaR O2ter
reactant: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
name: O2 transport, endoplasmic reticulum
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110011#
fast: false

metaR r1600
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110011#
reversible: true
type: Reaction
product: MODEL1310110011#

metaR r0651
modifier: MODEL1310110011#
reactant: MODEL1310110011#
product: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
kinetic law: MODEL1310110011#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is version of: http://identifiers.org/ec-code/1.5.1.2
reversible: true
fast: false

metaR r1464
fast: false
name: Active transport
reactant: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000185
product: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#
reversible: true

metaR EICOSTETCPT2
name: carnitine transferase
is described by: ECO:0000000
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110011#
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: false
is: SBO:0000176
type: Reaction
fast: false

metaM octa c
type: Species
is: SBO:0000247
initial amount: NaN
is: C06423
name: octanoate (n-C8:0)
is: CHEBI:25646
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C8H15O2 CHARGE: -1
is: HMDB00482
constant: false

metaM 3hdececrn e
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C23H43NO5 CHARGE: 0
boundary condition: false
name: 3-hydroxyhexadecenoylcarnitine
type: Species
constant: false
is: HMDB13325
initial concentration: 1.0

metaM dmnoncrn m
name: 4,8 dimethylnonanoyl carnitine
initial concentration: 1.0
type: Species
constant: false
is: HMDB06202
is: SBO:0000247
has only substance units: false
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
initial amount: NaN
boundary condition: false

metaM 1pyr5c c
initial concentration: 1.0
initial amount: NaN
is: C03912
is: SBO:0000247
is: HMDB01301
name: 1-Pyrroline-5-carboxylate
boundary condition: false
has only substance units: false
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: CHEBI:15893
constant: false
type: Species

metaM 3aib D m
is: SBO:0000247
name: D-3-Amino-isobutanoate
initial amount: NaN
is: C03265
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
has only substance units: false
is: HMDB02299

metaM tettet6 c
is: SBO:0000247
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB06246
constant: false
initial amount: NaN
name: tetracosatetraenoic acid n-6

metaR r1078
type: Reaction
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110011#
reversible: false
name: Vesicular transport
kinetic law: MODEL1310110011#

metaR r0650
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
reversible: true
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.36
reactant: MODEL1310110011#
product: MODEL1310110011#

metaR EICOSTETCPT1
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine O-palmitoyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110011#
reversible: false

metaM dodecanac c
is: HMDB00623
boundary condition: false
name: Dodecanedioic acid
type: Species
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C12H20O4 CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110011#_a8e0b8c5_d2ce_4a72_9e64_4a8070da8023
is: SBO:0000252
is encoded by: hsa:3418
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: true
name: IDH2
is: P48735

http://identifiers.org/biomodels.db/MODEL1310110011#_5dd9d114_a50c_4835_a491_1603ddcff04e
is encoded by: hsa:10400
name: PEMT
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252

metaR r2519
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
name: Utilized transport
product: MODEL1310110011#

metaR CSND
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
type: Reaction
name: Cytosine deaminase
product: MODEL1310110011#
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110011#_0ce6fc08_7e5f_4bcf_8f2e_88ff041b5969
is: SBO:0000252
is encoded by: hsa:6519
boundary condition: true
initial amount: NaN
is: Q07837
name: SLC3A1
constant: false
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_2f9a7b58_f5c6_4ced_a1cc_f30356758b03
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: Q9BV10
initial amount: NaN
is encoded by: hsa:79087
name: ALG12

metaM pmtcoa m
is: C00154
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: Palmitoyl-CoA (n-C16:0CoA)
has only substance units: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
initial concentration: 1.0
constant: false
is: HMDB01338
is: CHEBI:57379
type: Species

metaR URAt
modifier: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000269
type: Reaction
name: uracil transport via facilated diffusion
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_adaf0361_a255_4eca_a7ee_82f62da6ee6e
is: SBO:0000252
is encoded by: hsa:AI971036
type: Species
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
name: _AI971036_1_x
initial amount: NaN

metaR BMTer L
name: B mannosyltransferase, endoplasmic reticulum
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110011#
reversible: false
product: MODEL1310110011#
reactant: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_ffa2184c_5009_4098_bc18_f6f5629d3f6d
is: Q96CD2
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:60490
name: PPCDC

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_21bd98a1_a218_4743_b962_6af189aea705
initial amount: NaN
has part: O94777
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:54344
has part: Q86TM7
has part: O60762
is encoded by: hsa:8813
is: SBO:0000297
constant: false
has only substance units: false
is encoded by: hsa:8818
name: DPM3:DPM1:DPM2

http://identifiers.org/biomodels.db/MODEL1310110011#_b5ae3739_55d1_45ef_b7b3_f2772a45aa21
is encoded by: hsa:AI285872
name: _AI285872_1_c
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
initial concentration: NaN

metaR RE0453N
modifier: MODEL1310110011#
fast: false
name: RE0453
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110011#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:

metaM ipdp c
name: Isopentenyl diphosphate
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
constant: false
type: Species
is: C00129
is: SBO:0000247
is: CHEBI:128769
is: HMDB01347
initial concentration: 1.0

metaM HC02187 c
name: reverse-triiodthyronine
initial amount: NaN
has only substance units: false
is: CHEBI:28774
boundary condition: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_4e300659_4501_4002_b2b4_223cd8344297
is: Q8IZH9
type: Species
has only substance units: false
name: GCH1
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:2643

metaM glygn5 e
constant: false
is: SBO:0000247
is: HMDB06372
type: Species
is: CHEBI:33871
name: glycogen, structure 5 (glycogenin-2[1,4-Glc])
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C12H21O11X CHARGE: 0

metaR r2308
product: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110011#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

http://identifiers.org/biomodels.db/MODEL1310110011#_21e86332_8570_42ac_91cb_330ea4034685
name: ST3GAL3
is: SBO:0000252
type: Species
is encoded by: hsa:6487
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM tridcoa m
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C34H56N7O17P3S CHARGE: -4
is: SBO:0000247
is: HMDB13109
boundary condition: false
constant: false
name: tridecanoylcoa

metaR HDECEACBP
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecenoylcoa from mitochondria into the cytosol
type: Reaction

metaM glyb m
is: HMDB00043
constant: false
initial amount: NaN
name: glycine betaine
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: CHEBI:17750
has only substance units: false

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaR PROSTGH2t
fast: false
kinetic law: MODEL1310110011#
name: Prostaglandin H2 transport
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110011#
reversible: true
product: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110011#_5db1b226_8664_4d97_8062_d4cf1e852098
has only substance units: false
type: Species
name: MAN1C1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:57134
is: Q9NR34
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_9693e656_eec0_4f20_9643_75c4488e481c
name: PIGX
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:54965
is: Q8TBF5
constant: false
type: Species
initial concentration: NaN

metaR CITtbm
product: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
name: citrate transport, mitochondrial
modifier: MODEL1310110011#
reversible: true

metaR LEUTA
is version of: http://identifiers.org/ec-code/2.6.1.42
type: Reaction
is: SBO:0000176
product: MODEL1310110011#
name: leucine transaminase
reversible: true
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
reactant: MODEL1310110011#
is described by: ECO:0000269
kinetic law: MODEL1310110011#
fast: false

metaR r0812
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
kinetic law: MODEL1310110011#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.41
is: SBO:0000185
fast: false

metaR MALSO4tm
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000269
name: Malate:sulfate antiport, mitochondrial
product: MODEL1310110011#
type: Reaction
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110011#_beba032a_bb3d_4907_9535_6123d9eccf6d
has only substance units: false
initial concentration: NaN
name: HGD
type: Species
constant: false
is: Q93099
is encoded by: hsa:3081
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR GLYSARPEPT1tc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Glycylsarcosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine, renal cells and brain.
type: Reaction

metaM h2o2 e
type: Species
is: HMDB03125
boundary condition: false
is: SBO:0000247
is: CHEBI:16240
has only substance units: false
name: hydrogen peroxide
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
constant: false

metaM HC00342 m
constant: false
initial amount: NaN
is: CHEBI:16383
name: cis-aconitate(3-)
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
is: SBO:0000247
type: Species

metaR r2534
is: SBO:0000185
product: MODEL1310110011#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#

metaR PCHOL HSter
product: MODEL1310110011#
name: phosphatidylcholine scramblase
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
reactant: MODEL1310110011#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000

metaR O2tm
type: Reaction
reactant: MODEL1310110011#
name: O2 transport (diffusion)
is described by: ECO:0000000
product: MODEL1310110011#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF

metaM nad r
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00902
initial concentration: 1.0
has only substance units: false
name: NAD(1-)
is: SBO:0000247
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
is: CHEBI:57540

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaM akg c
is: HMDB00208
name: 2-Oxoglutarate
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: C00026
is: SBO:0000247
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: CHEBI:16810

http://identifiers.org/biomodels.db/MODEL1310110011#_75766e7c_44d5_4495_bfff_ed2ac5422efc
name: _H53099_1_m
has only substance units: false
is encoded by: hsa:H53099
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_40d1976f_8f10_44a4_8742_21ea6f0440f0
initial concentration: NaN
has only substance units: false
type: Species
is: P31939
is encoded by: hsa:471
constant: false
boundary condition: true
name: ATIC
is: SBO:0000252
initial amount: NaN

metaM glyc3p c
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C00093
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
type: Species
is: HMDB00126
initial concentration: 1.0
name: Glycerol 3-phosphate
is: CHEBI:57597

metaR O2tp
is: SBO:0000185
reversible: true
reactant: MODEL1310110011#
type: Reaction
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false
name: O2 transport, peroxisomal
kinetic law: MODEL1310110011#

metaR r0365
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.1.72
modifier: MODEL1310110011#
reactant: MODEL1310110011#
reversible: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110011#_3d92679e_a576_4ff0_95dc_ff89192bb22d
name: BDH1
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:622
constant: false
is: Q02338
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_3a5c77da_3096_4bdc_8a6d_ac8e1cee3deb
is encoded by: hsa:4830
is: P15531
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
name: NME1
boundary condition: true
initial amount: NaN

metaM h2o2 c
type: Species
constant: false
boundary condition: false
is: C00027
has only substance units: false
is: HMDB03125
is: SBO:0000247
is: CHEBI:16240
name: Hydrogen peroxide
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial amount: NaN

metaM 13 cis retn r
type: Species
name: 13-cis-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
is: D00348
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/7847414
initial amount: NaN
boundary condition: false
is: HMDB06219
initial concentration: 1.0
constant: false

metaM 5aop m
has only substance units: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
boundary condition: false
is: SBO:0000247
is: C00430
initial concentration: 1.0
is: HMDB01149
is: CHEBI:17549
initial amount: NaN
type: Species
constant: false
name: 5-Amino-4-oxopentanoate

metaR r2532
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
reactant: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
product: MODEL1310110011#
kinetic law: MODEL1310110011#

metaR r0656
reversible: false
type: Reaction
reactant: MODEL1310110011#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110011#
is: SBO:0000176
name: 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:

metaR ACGAMPM
is: SBO:0000176
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
reactant: MODEL1310110011#
is described by: ECO:0000269
modifier: MODEL1310110011#
type: Reaction
reversible: true
product: MODEL1310110011#
name: phosphoacetylglucosamine mutase
is version of: http://identifiers.org/ec-code/5.4.2.3
fast: false
kinetic law: MODEL1310110011#

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaR CHOLt4
modifier: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
reversible: true
type: Reaction
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
is described by: ECO:0000269
name: choline, sodium cotransport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_118aaacd_8672_48a1_84bb_ec2f4eec8874
is encoded by: hsa:8875
is: SBO:0000252
is: O95498
has only substance units: false
name: VNN2
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_7b95500c_1e16_4360_9311_6307e42202c0
is: Q9UMR5
name: PPT2
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:9374
initial concentration: NaN
is: SBO:0000252

metaM 3ttetddcoacrn c
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C21H37NO5 CHARGE: 0
initial amount: NaN
is: HMDB02014
boundary condition: false
is: SBO:0000247
constant: false

metaR FAOXC102m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

metaM akg e
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial concentration: 1.0
name: 2-oxoglutarate(2-)
type: Species
constant: false
is: HMDB00208
is: CHEBI:16810

metaR SUCOAS1m
is described by: ECO:0000000
reversible: true
name: Succinate--CoA ligase (GDP-forming)
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
fast: false
type: Reaction
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176

metaR MGSA
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:Previously EC 4.2.99.11 this rxn represents the enzymatic conversion or non-enzymatic fragmentation of dhap to mthgxl - NCD
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: false
fast: false
is described by: ECO:0000000
name: methylglyoxal synthase
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_83168984_dae5_49eb_9cb6_d932d91e1adf
constant: false
is: Q9BW60
type: Species
is encoded by: hsa:64834
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ELOVL1

http://identifiers.org/biomodels.db/MODEL1310110011#_e7f14c18_f654_4e76_9136_612b451ceb5f
name: LDHB
constant: false
is: SBO:0000252
boundary condition: true
is: P07195
initial amount: NaN
has only substance units: false
is encoded by: hsa:3945
type: Species
initial concentration: NaN

metaR RE1533M
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110011#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000000
name: RE1533
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_5217be47_49f2_4b0d_a29a_a655f73bd7ed
is: D3DWC4
constant: false
type: Species
is encoded by: hsa:259230
boundary condition: true
name: SGMS1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM hdd2coa c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: SBO:0000247
is: CHEBI:61526
has only substance units: false
is: C05272
name: trans-Hexadec-2-enoyl-CoA
type: Species
initial amount: NaN
is: HMDB03945
constant: false

metaR r2538
reactant: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#
name: Utilized transport
fast: false
type: Reaction
is: SBO:0000185

metaM c4crn c
initial amount: NaN
name: butyryl carnitine
is: http://identifiers.org/pubchem.compound/213144
notes: FORMULA: C11H21NO4 CHARGE: 0
is: SBO:0000247
is: C02862
constant: false
is: HMDB02013
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species

metaR ESTRADIOLtr
kinetic law: MODEL1310110011#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
name: estradiol intracellular transport
is: SBO:0000185
product: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR ALAt2r
name: L-alanine reversible transport via proton symport
modifier: MODEL1310110011#
is described by: ECO:0000304
product: MODEL1310110011#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is: SBO:0000185

metaM 5mthf e
name: 5-Methyltetrahydrofolate
is: CHEBI:3729
constant: false
boundary condition: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: C00440
is: HMDB01396
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_f3b7d5ce_a9e4_4860_ad79_8f55a9e95552
initial amount: NaN
is encoded by: hsa:8803
has only substance units: false
constant: false
is: SBO:0000252
name: SUCLA2
initial concentration: NaN
boundary condition: true
type: Species
is: E5KS60

metaM dodecanac x
name: Dodecanedioic acid
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00623
notes: FORMULA: C12H20O4 CHARGE: -2
is: SBO:0000247
type: Species

metaR r0655
is described by: ECO:0000000
kinetic law: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
reactant: MODEL1310110011#
is: SBO:0000176
fast: false
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
type: Reaction
modifier: MODEL1310110011#
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.5.1.2

metaR r2537
kinetic law: MODEL1310110011#
name: Utilized transport
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110011#
type: Reaction
product: MODEL1310110011#

metaR SUBERICACT
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of suberic acid for formation of suberyl carnitine
type: Reaction

metaR NDPK8n
reactant: MODEL1310110011#
is described by: ECO:0000304
modifier: MODEL1310110011#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110011#
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
reversible: true
product: MODEL1310110011#

metaM pmtcoa c
type: Species
has only substance units: false
is: C00154
initial amount: NaN
boundary condition: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: HMDB01338
initial concentration: 1.0
is: CHEBI:3454
name: Palmitoyl-CoA (n-C16:0CoA)
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_c2864faf_5e72_466a_97c9_5432efbfb23f
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: Q6AI14
initial concentration: NaN
is encoded by: hsa:389015
name: SLC9A4

http://identifiers.org/biomodels.db/MODEL1310110011#_a94ab0cc_c8ce_4693_bb66_9c5e57e1798f
is encoded by: hsa:222
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
name: ALDH3B2
is: P48448
is: SBO:0000252
type: Species

metaM tchola c
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
is: SBO:0000247
is: CHEBI:36257
type: Species
is: HMDB00036
name: taurocholic acid
initial concentration: 1.0

metaM 6hoxmelatn c
is: HMDB04081
type: Species
name: 6-Hydroxymelatonin
initial amount: NaN
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/7954
is: SBO:0000247
has only substance units: false
notes: FORMULA: C13H16N2O3 CHARGE: 0 INCHI: InChI=1/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C05643
boundary condition: false
is: C05643

metaR LNLCCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: false
modifier: MODEL1310110011#
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
reactant: MODEL1310110011#
name: carnitine transferase

http://identifiers.org/biomodels.db/MODEL1310110011#_0bc3dfc2_4e2d_4c72_8f58_1a34a4fa2887
type: Species
has only substance units: false
is: A6NN98
boundary condition: true
constant: false
is encoded by: hsa:8898
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: MTMR2

metaM 2mb2coa c
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
name: 2-methylcrotonoyl-CoA(4-)
constant: false
is: HMDB02054
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1
initial concentration: 1.0
is: SBO:0000247

metaM r5p c
is: HMDB00618
initial concentration: 1.0
is: C00117
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
has only substance units: false
is: CHEBI:18189
is: SBO:0000247
boundary condition: false
type: Species
name: alpha-D-Ribose 5-phosphate
constant: false

metaR LYSOXp
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110011#
product: MODEL1310110011#
name: L-lysine oxidase, peroxisomal

metaM c4crn e
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/213144
is: C02862
name: butyryl carnitine
notes: FORMULA: C11H21NO4 CHARGE: 0
is: HMDB02013
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaR r0652
modifier: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.2
reactant: MODEL1310110011#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110011#
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
product: MODEL1310110011#
is: SBO:0000176

metaR GLCt1r
reactant: MODEL1310110011#
fast: false
modifier: MODEL1310110011#
is described by: ECO:0000269
kinetic law: MODEL1310110011#
is: SBO:0000185
product: MODEL1310110011#
name: glucose transport (uniport)
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

metaM 5mthf c
boundary condition: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
initial amount: NaN
is: C00440
is: CHEBI:3729
constant: false
is: HMDB01396
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: 5-Methyltetrahydrofolate

metaR PPAm
fast: false
reversible: false
modifier: MODEL1310110011#
type: Reaction
is described by: ECO:0000269
name: inorganic diphosphatase
kinetic law: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.6.1.1
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110011#_edb8818c_4800_48ea_bc5e_354307b2e1d1
initial amount: NaN
type: Species
has only substance units: false
is: B7Z4Y6
is encoded by: hsa:249
initial concentration: NaN
name: ALPL
constant: false
is: SBO:0000252
boundary condition: true

metaR LNLCCPT1
name: carnitine O-palmitoyltransferase
is: SBO:0000176
type: Reaction
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110011#
modifier: MODEL1310110011#
is described by: ECO:0000269
reversible: false

metaR r2535
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true
product: MODEL1310110011#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_8fc510d0_bdc2_421f_b0e8_bafcf4955635
boundary condition: true
initial concentration: NaN
name: _AI972237_1_c
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:AI972237
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_84395671_b017_4f60_a48b_574b90870d85
initial amount: NaN
initial concentration: NaN
is: P49448
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
name: GLUD2
is encoded by: hsa:2747
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_f23d69f4_86ef_4294_ad40_4bf387896663
boundary condition: true
is encoded by: hsa:5336
name: PLCG2
is: P16885
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR DNDPt27m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
is described by: ECO:0000269
name: dCDP transport via dTDP antiport
modifier: MODEL1310110011#
type: Reaction
product: MODEL1310110011#
fast: false
reversible: false
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#

metaM odecrn c
name: octadecenoyl carnitine
boundary condition: false
type: Species
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
is: CHEBI:57394
is: C00412
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB01114
is: SBO:0000247

metaM estradiol e
is: HMDB00151
initial concentration: 1.0
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
constant: false
is: CHEBI:16469
is: SBO:0000247
boundary condition: false
name: estradiol
type: Species
has only substance units: false
initial amount: NaN

metaR DAG HSter
reactant: MODEL1310110011#
name: diacylglycerol ER export
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000185
reversible: false
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110011#_1fec46cf_9041_4667_8dc7_3cde9b899b9a
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:AA177072
name: _AA177072_1_c
type: Species
has only substance units: false
is: SBO:0000252

metaR ICDHy
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42
reactant: MODEL1310110011#
name: isocitrate dehydrogenase (NADP)
notes: GENE_ASSOCIATION: (3417.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES:Two reactions (ICDH1 and ICDH2) for isocitrate dehydrogenase
fast: false
modifier: MODEL1310110011#
is described by: ECO:0000269
reversible: false
product: MODEL1310110011#
is: SBO:0000176
kinetic law: MODEL1310110011#

metaM tchola e
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C26H45NO7S CHARGE: 0
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
name: taurocholic acid
is: HMDB00036

metaR CYSSERNaEx
is: SBO:0000185
modifier: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
is described by: ECO:0000269
name: L-serine/L-cysteine Na-dependent exchange (Cys-L in)
product: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

http://identifiers.org/biomodels.db/MODEL1310110011#_9562d5c0_fb45_4a68_9387_38ad6bd020f6
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:4694
type: Species
constant: false
is: Q6IBB5
name: NDUFA1
initial concentration: NaN

metaM HC00695 m
initial amount: NaN
type: Species
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
constant: false
is: SBO:0000247
initial concentration: 1.0
name: S-Succinyldihydrolipoamide
boundary condition: false
is: CHEBI:17432
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_ba260854_b44a_42b6_8c5d_dbcb0b90d419
is: SBO:0000252
constant: false
name: HADHB
boundary condition: true
is encoded by: hsa:3032
has only substance units: false
type: Species
is: P55084
initial concentration: NaN
initial amount: NaN

metaR r0381
is: SBO:0000176
kinetic law: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
reactant: MODEL1310110011#
fast: false
type: Reaction
is described by: ECO:0000000
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_cd144740_1fd4_427a_aee5_5ac2d4655afc
initial concentration: NaN
is: P43155
type: Species
is encoded by: hsa:1384
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: CRAT
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_94d779c5_96b8_41bc_88a0_dbe24ae5aaf6
is: SBO:0000252
is: O60503
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:115
type: Species
initial concentration: NaN
name: ADCY9
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_ff99a4dd_6698_4f82_b5c8_5f5c56865e88
initial concentration: NaN
type: Species
boundary condition: true
is: B7Z6M3
constant: false
initial amount: NaN
name: DGKZ
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8525

metaM 2oxoadp m
is: HMDB00225
is: SBO:0000247
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
initial amount: NaN
boundary condition: false
name: 2-oxoadipate(2-)
initial concentration: 1.0
constant: false
is: CHEBI:57499
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_fed25c9a_02e3_4014_b6d1_0c97549f7781
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: B7Z1R0
is encoded by: hsa:57282
constant: false
initial concentration: NaN
type: Species
name: SLC4A10
boundary condition: true

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_a589685e_82a7_4da6_be5f_b5f0968ef43b
name: COX7A1
is encoded by: hsa:1346
constant: false
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P24310

metaR r0360
reactant: MODEL1310110011#
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
modifier: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is version of: http://identifiers.org/ec-code/6.2.1.16
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_b69efa9d_0d24_4e7c_9c35_3871d8e49e80
constant: false
name: CYP27A1
is encoded by: hsa:1593
is: Q02318
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaR O16G1e
modifier: MODEL1310110011#
is: SBO:0000176
is described by: ECO:0000000
name: oligo-1,6-glucosidase (glygn4 -> glygn5), extracellular
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.2.1.10
reversible: false
fast: false
type: Reaction

metaR FACOAL200
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true
product: MODEL1310110011#
name: fatty-acid--CoA ligase
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110011#
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_83477a3e_c93b_468a_90ce_80d960687c46
initial concentration: NaN
constant: false
initial amount: NaN
name: SLC7A8
is encoded by: hsa:23428
boundary condition: true
is: Q86U05
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_6d70e2b8_bef3_47a7_95b9_359e8bacb46b
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:50808
is: E7ET30
has only substance units: false
name: AK3
constant: false
boundary condition: true
initial concentration: NaN

metaM HC00342 c
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:16383
has only substance units: false
initial amount: NaN
name: cis-aconitate(3-)
is: SBO:0000247
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
boundary condition: false

metaR HTDCACBP
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxytetradecanoyl-CoA from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_566c161f_90d2_4e5b_8305_e271de06a679
is: Q9NWU1
is encoded by: hsa:54995
constant: false
type: Species
name: OXSM
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM utp n
constant: false
is: CHEBI:46398
initial amount: NaN
is: HMDB00285
name: UTP(4-)
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075

metaR LEUKTRD4tr
reactant: MODEL1310110011#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
is: SBO:0000185
type: Reaction
name: leukotriene intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110011#_32677ea4_1316_4f71_9f8f_275ed151b8c4
constant: false
has only substance units: false
is: Q7GXZ8
type: Species
name: COX2
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4513
is: SBO:0000252

metaR AMACR2p
is described by: ECO:0000304
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/5.1.99.4
modifier: MODEL1310110011#
name: alpha-methylacyl-CoA racemase (reductase)
type: Reaction
product: MODEL1310110011#
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23600.1) or (23600.2) SUBSYSTEM: Bile acid synthesis EC Number: 5.1.99.4 Confidence Level: 2 AUTHORS: NOTES:should be analogous to AMACRp as per KEGG - in this case: reductase not a racemase NJ

http://identifiers.org/biomodels.db/MODEL1310110011#_479fe718_10ff_476b_80af_d53b02df4202
is: SBO:0000252
is encoded by: hsa:2181
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: ACSL3
is: O95573
has only substance units: false
type: Species

metaR O2St
kinetic law: MODEL1310110011#
product: MODEL1310110011#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is: SBO:0000185
name: superoxide anion transport via diffusion (extracellular)
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_72ad2057_3824_43c2_8d14_4cb02eb1d1f3
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:D87002
type: Species
initial amount: NaN
constant: false
boundary condition: true
name: _D87002_1_e
has only substance units: false

metaR FAOXC226205m
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
reactant: MODEL1310110011#
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of long chain fatty acid
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110011#
reversible: false
kinetic law: MODEL1310110011#

metaM HC00250 c
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:29919
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
name: hydrosulfide

metaR BILIRUBtr
fast: false
is: SBO:0000185
reactant: MODEL1310110011#
product: MODEL1310110011#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
name: lipid, flip-flop intracellular transport

metaR r0384
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
reactant: MODEL1310110011#
reversible: false
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
kinetic law: MODEL1310110011#
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110011#

metaM leuktrD4 r
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: HMDB03080
name: Leukotriene D4
type: Species
initial concentration: 1.0
is: CHEBI:28666

metaM lnlncacrn m
has only substance units: false
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
type: Species
name: alpha-linolenyl carnitine
initial amount: NaN
is: SBO:0000247
is: HMDB06319
boundary condition: false
constant: false
initial concentration: 1.0

metaR r0385
kinetic law: MODEL1310110011#
fast: false
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
reversible: false
reactant: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaR SPH1Pte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
is described by: ECO:0000000
product: MODEL1310110011#
is: SBO:0000185
reactant: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
name: sph1p transport
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_60321999_6325_40c3_b4c3_2d67b5e94ba2
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
constant: false
is encoded by: hsa:151531
is: O95045
initial amount: NaN
name: UPP2
has only substance units: false

metaM nad m
initial amount: NaN
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/3305
has only substance units: false
is: SBO:0000247
type: Species
is: C00003
is: CHEBI:57540
boundary condition: false
is: HMDB00902
name: Nicotinamide adenine dinucleotide

metaR MM8Cg
modifier: MODEL1310110011#
type: Reaction
reversible: false
fast: false
product: MODEL1310110011#
reactant: MODEL1310110011#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is: SBO:0000176
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.113
kinetic law: MODEL1310110011#

metaR FACOAL203
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
is described by: ECO:0000000
product: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
reactant: MODEL1310110011#

metaM dece4coa m
constant: false
name: 4-decenoylcoa
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB02145
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4

metaR r0363
reversible: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_d489a03e_e2ec_46d9_84e4_610d1ecf886c
boundary condition: true
is: Q8WUM9
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6574
type: Species
name: SLC20A1
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_9bac4e99_657c_4902_b92d_395b70195d8b
is: SBO:0000252
constant: false
initial concentration: NaN
is: P18405
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:6715
has only substance units: false
name: SRD5A1

metaR ACGAMK
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
fast: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.1.59
is described by: ECO:0000269
product: MODEL1310110011#
is: SBO:0000176
reversible: false
modifier: MODEL1310110011#
name: N-acetylglucosamine kinase
type: Reaction

metaR FACOAL205
fast: false
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
name: fatty-acid--CoA ligase
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaR PRPNCOAHYDm
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.18
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110011#
modifier: MODEL1310110011#
reversible: false
is: SBO:0000176
name: Propenoyl-CoA hydrolase (m)
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR FAOXC14C14OHm
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C14OH)m
type: Reaction

metaR CAATPS
is version of: http://identifiers.org/ec-code/3.6.3.8
fast: false
reversible: false
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
product: MODEL1310110011#
name: Ca ATPase
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#

metaR r0386
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
reactant: MODEL1310110011#
reversible: false
fast: false
name: 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110011#
product: MODEL1310110011#

metaR FACOAL204
reactant: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
modifier: MODEL1310110011#
fast: false
name: fatty-acid--CoA ligase
is: SBO:0000176
product: MODEL1310110011#
is described by: ECO:0000269
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true

metaM HC00250 e
initial concentration: 1.0
is: CHEBI:29919
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
type: Species
name: hydrosulfide
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN

metaM 3ttetddcoacrn e
is: HMDB02014
boundary condition: false
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C21H37NO5 CHARGE: 0
type: Species
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_432a9112_6cab_4f27_b6ba_c061abdf3b14
is: E9PB82
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3295
constant: false
name: HSD17B4
initial concentration: NaN
type: Species
boundary condition: true

metaM CE2424 m
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
initial amount: NaN
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
is: HMDB11123
is: CHEBI:28387
has only substance units: false
boundary condition: false

metaM pchol hs c
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
is: CHEBI:16110
initial amount: NaN
name: Phosphatidylcholine
has only substance units: false
boundary condition: false

metaM melatn c
initial concentration: 1.0
has only substance units: false
is: HMDB01389
is: SBO:0000247
is: CHEBI:16796
notes: FORMULA: C13H16N2O2 CHARGE: 0 INCHI: InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C01598
constant: false
type: Species
name: melatonin
initial amount: NaN
boundary condition: false

metaR PPAt
is: SBO:0000185
type: Reaction
product: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
kinetic law: MODEL1310110011#
reversible: false
reactant: MODEL1310110011#
name: Propionate transport, diffusion
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110011#_c91d4903_bc98_4c6d_a7ac_14b5a517ecf0
boundary condition: true
constant: false
type: Species
is: A8K596
initial concentration: NaN
is: SBO:0000252
name: SARDH
is encoded by: hsa:1757
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_f9b98db6_9e34_4784_8a6d_06face9abf85
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:5150
is: SBO:0000252
name: PDE7A
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_69456cc3_5f5a_40a2_82fb_26bb535ba722
has only substance units: false
is encoded by: hsa:80724
is: G3XAJ0
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
name: ACAD10
type: Species
is: SBO:0000252

metaM estradiol c
type: Species
initial amount: NaN
is: HMDB00151
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
boundary condition: false
is: SBO:0000247
name: estradiol
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:16469

http://identifiers.org/biomodels.db/MODEL1310110011#_858aef35_a5d1_463f_8e6b_d500d72ca1b0
is: SBO:0000252
is: P31937
is encoded by: hsa:11112
has only substance units: false
initial amount: NaN
name: HIBADH
boundary condition: true
constant: false
type: Species
initial concentration: NaN

metaR S6T9g
is: SBO:0000176
fast: false
modifier: MODEL1310110011#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
reversible: false
kinetic law: MODEL1310110011#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110011#_0f16f289_dd91_4b49_b027_c039c533c6ff
name: COX4I2
type: Species
is: Q96KJ9
initial concentration: NaN
constant: false
is encoded by: hsa:84701
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM mescoa m
is: CHEBI:27969
has only substance units: false
boundary condition: false
name: Mesaconyl-CoA
is: C06028
type: Species
is: SBO:0000247
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_684a5854_9be7_47ee_bffa_ae50692bd415
initial amount: NaN
is encoded by: hsa:51095
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: TRNT1
boundary condition: true
is: Q96Q11
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_0ee22755_cf84_46ff_b306_137df167b9f8
has only substance units: false
initial amount: NaN
name: PLCB1
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:23236
type: Species

metaR GLNyLATthc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glutamine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_98b4209d_1dd3_4450_ac9c_f7d1d3143cc8
type: Species
name: ALDH6A1
is: Q02252
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4329

metaM lneldccoa c
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/9543677
boundary condition: false
is: HMDB06521
has only substance units: false
constant: false
name: linoelaidyl coenzyme A
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN

metaR r1154
kinetic law: MODEL1310110011#
fast: false
name: EC:1.2.7.2
type: Reaction
is described by: ECO:0000000
product: MODEL1310110011#
is: SBO:0000176
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
reversible: true

metaR CYTK9n
fast: false
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#
is: SBO:0000176
name: cytidylate kinase (CMP,dCTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110011#
reactant: MODEL1310110011#

metaR THMP
type: Reaction
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD
is described by: ECO:0000000
product: MODEL1310110011#
name: thiamin phosphatase
reactant: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#

metaM pristcoa c
is: CHEBI:51341
type: Species
name: pristanoyl coa
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
initial amount: NaN

metaR r2014
product: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR GLYt2r
fast: false
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000185
reactant: MODEL1310110011#
name: glycine reversible transport via proton symport
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is described by: ECO:0000304
reversible: true
modifier: MODEL1310110011#

metaR FRDPtcr
fast: false
type: Reaction
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
kinetic law: MODEL1310110011#
reversible: true
is: SBO:0000185
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
reactant: MODEL1310110011#
is described by: ECO:0000134

metaR r1156
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
fast: false
product: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
reversible: true

metaM retinal cis 13 r
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
name: 13-cis-retinal
constant: false
is: HMDB06220
boundary condition: false
has only substance units: false
is: CHEBI:45487

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

metaR r0926
name: Postulated transport reaction
reversible: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
product: MODEL1310110011#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#

metaR 3MOPt2im
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
product: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#

metaM HC01603 c
is: C00234
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
name: 10-Formyltetrahydrofolate
has only substance units: false
is: CHEBI:57454
is: SBO:0000247
constant: false

metaR GALU
is described by: ECO:0000134
is: SBO:0000176
product: MODEL1310110011#
type: Reaction
reversible: true
modifier: MODEL1310110011#
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.7.9
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
fast: false
name: UTP-glucose-1-phosphate uridylyltransferase

metaM utp e
type: Species
is: HMDB00285
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
name: UTP(4-)
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:46398

metaR 13DAMPPOX
type: Reaction
kinetic law: MODEL1310110011#
is: SBO:0000176
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.4.3.21
fast: false
product: MODEL1310110011#
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.22
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
is described by: ECO:0000212
modifier: MODEL1310110011#
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)

metaR NADPHtru
is described by: ECO:0000000
type: Reaction
reversible: false
reactant: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
name: NADPH transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
kinetic law: MODEL1310110011#
fast: false

metaM q10 e
type: Species
is: HMDB01072
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
name: ubiquinone-10
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:46245
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_eb3a12ce_daa3_4056_b25d_3fac95ecf736
has only substance units: false
name: HAO2
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:51179
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q9NYQ3

metaR r2013
type: Reaction
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110011#
reversible: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110011#
product: MODEL1310110011#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_f7ba3c29_2f19_4794_aae1_eea99d8a8953
is encoded by: hsa:4830
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000297
name: NME1:NME2
constant: false

metaR CSNt
is described by: ECO:0000269
fast: false
modifier: MODEL1310110011#
name: cytosine transport via facilated diffusion
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
reactant: MODEL1310110011#

metaR FAOXC16OHC16r
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_d72fbac1_f7ee_48b7_9741_d00705d24633
is encoded by: hsa:171425
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
name: CLYBL
is: SBO:0000252
constant: false

metaR PAIL HStn
product: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: phosphatidylinositol nuclear transport (diffusion)
reversible: true
kinetic law: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110011#

metaM malthx e
boundary condition: false
name: Maltohexaose
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
initial concentration: 1.0
is: C01936

metaM cmpacna c
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial concentration: 1.0
has only substance units: false
constant: false
name: CMP-N-acetyl-beta-neuraminate(2-)
is: HMDB01176
is: SBO:0000247
is: CHEBI:57812

http://identifiers.org/biomodels.db/MODEL1310110011#_1ed1a68b_29a0_4d55_8c68_7b64ad835149
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:8654
boundary condition: true
has only substance units: false
type: Species
is: O76074
name: PDE5A

metaR GALT
is: SBO:0000176
reactant: MODEL1310110011#
reversible: true
modifier: MODEL1310110011#
fast: false
type: Reaction
product: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
is version of: http://identifiers.org/ec-code/2.7.7.12
name: galactose-1-phosphate uridylyltransferase

http://identifiers.org/biomodels.db/MODEL1310110011#_b922acb8_297c_4378_bced_bc1763f229c0
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3284
is: SBO:0000252
constant: false
name: HSD3B2
is: P26439
type: Species

metaM cys L c
initial concentration: 1.0
name: L-cysteine
is: HMDB00574
is: SBO:0000247
initial amount: NaN
is: CHEBI:17561
constant: false
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099

metaR PSP L
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.3
reactant: MODEL1310110011#
name: phosphoserine phosphatase (L-serine)
fast: false
reversible: false

metaR GCC2cm
reactant: MODEL1310110011#
is described by: ECO:0000269
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.10
reversible: true
product: MODEL1310110011#
name: glycine-cleavage complex (lipoamide), mitochondrial
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_d282c018_94e7_4a91_968c_fd64a09605cf
type: Species
initial amount: NaN
is: E9PB82
initial concentration: NaN
name: HSD17B4
constant: false
is: SBO:0000252
is encoded by: hsa:3295
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_b9fd212c_d88d_4643_9efe_0fcefd7850df
boundary condition: true
is encoded by: hsa:83549
has only substance units: false
is: Q5JT09
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
name: UCK1
type: Species

metaR HOCDACBP
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxyoctadecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR FAOXC1811603m
reactant: MODEL1310110011#
reversible: false
type: Reaction
kinetic law: MODEL1310110011#
is: SBO:0000176
name: Beta oxidation fatty acid
product: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269

metaM prostgd2 e
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:57406
initial amount: NaN
name: prostaglandin D2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: SBO:0000247
is: HMDB01403
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_584fc203_6550_4c41_9f8c_d4955848b956
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:1723
has only substance units: false
is: Q02127
initial concentration: NaN
constant: false
name: DHODH

metaR FAOXC61C4m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

metaM gdp g
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial amount: NaN
type: Species
is: HMDB01201
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:58189
name: GDP(3-)
is: SBO:0000247
boundary condition: false

metaR SERTHRNaEx
is described by: ECO:0000269
reactant: MODEL1310110011#
product: MODEL1310110011#
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000185
fast: false
name: L-serine/L-threonine Na-dependent exchange (Ser-L in)

http://identifiers.org/biomodels.db/MODEL1310110011#_fcda15a1_50f6_45dd_a280_332ec233b906
boundary condition: true
is encoded by: hsa:3158
initial concentration: NaN
type: Species
is: P54868
name: HMGCS2
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN

metaM mi145p c
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
is: HMDB01498
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:203600
initial concentration: 1.0

metaR FAOXC5C3x
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C3)m
type: Reaction

metaR ELAIDCRNt
is described by: ECO:0000000
modifier: MODEL1310110011#
reversible: false
kinetic law: MODEL1310110011#
name: transport into the mitochondria (carnitine)
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_48ff5eb1_48ca_4411_8cfd_4d870a567a50
is: G5E960
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:5331
name: PLCB3
has only substance units: false
initial amount: NaN

metaR r2011
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
reactant: MODEL1310110011#
is described by: ECO:0000000
product: MODEL1310110011#
reversible: false

metaM fprica c
initial concentration: 1.0
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
is: C04734
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: CHEBI:58467
has only substance units: false
is: HMDB01439
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_86e64839_a18c_466e_9402_648b9aefeed2
has only substance units: false
constant: false
is encoded by: hsa:54963
is: SBO:0000252
name: UCKL1
is: Q53HM1
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR EX gthox LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxidized glutathione exchange
type: Reaction

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaR r1459
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110011#
reversible: true
is: SBO:0000185
reactant: MODEL1310110011#
name: Transport reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_e9d7dace_9838_4a17_ab7c_30d7528478a1
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
name: ADO
is: B3KXN9
is encoded by: hsa:84890
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_b3ac81b8_89c0_4f5f_8af8_b7c917e84ae3
constant: false
is: SBO:0000252
is encoded by: hsa:79646
initial amount: NaN
type: Species
is: Q9H999
boundary condition: true
has only substance units: false
name: PANK3
initial concentration: NaN

metaM hdd2coa m
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
has only substance units: false
name: trans-Hexadec-2-enoyl-CoA
is: CHEBI:61526
type: Species
is: C05272
is: HMDB03945
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_690a39f1_63a3_4400_887d_73e188214c24
boundary condition: true
is: SBO:0000252
name: AACS
constant: false
is: Q86V21
initial amount: NaN
is encoded by: hsa:65985
initial concentration: NaN
has only substance units: false
type: Species

metaR r0208
reversible: true
kinetic law: MODEL1310110011#
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
is: SBO:0000176
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
fast: false
type: Reaction
product: MODEL1310110011#
is described by: ECO:0000000
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/4.4.1.1

http://identifiers.org/biomodels.db/MODEL1310110011#_2729dad8_d101_4a94_8ba5_10b6a4361a5a
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:6487
name: ST3GAL3
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN

metaR HDECAACBP
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecanoylcoa from mitochondria into the cytosol
type: Reaction

metaM coa m
is: CHEBI:57287
is: C00010
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: Coenzyme A
constant: false
is: HMDB01423

metaR r2311
is: SBO:0000185
kinetic law: MODEL1310110011#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110011#
reversible: true
product: MODEL1310110011#

metaM gdp e
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
name: GDP(3-)
is: SBO:0000247
is: HMDB01201
has only substance units: false
is: CHEBI:58189

metaM 2mbcoa m
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
constant: false
name: 2-methylbutanoyl-CoA(4-)
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB01041
is: CHEBI:57336
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_8e099fb9_19ba_4c08_bf0e_3c9560076f0c
boundary condition: true
name: NME7
type: Species
is encoded by: hsa:29922
constant: false
is: Q9Y5B8
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_aa129af9_9b1f_4eae_93a8_2d327be97d2c
initial concentration: NaN
is: Q9UBX3
type: Species
name: SLC25A10
is encoded by: hsa:1468
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR r1616
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
modifier: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110011#

metaR r0502
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
is: SBO:0000176
product: MODEL1310110011#
modifier: MODEL1310110011#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.113
reactant: MODEL1310110011#
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4

metaM pro L e
boundary condition: false
name: L-proline
is: CHEBI:17203
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
type: Species
initial amount: NaN
is: HMDB00162

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaR r2312
type: Reaction
product: MODEL1310110011#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
kinetic law: MODEL1310110011#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reactant: MODEL1310110011#

metaM CE5586 c
boundary condition: false
constant: false
is: CHEBI:58732
type: Species
has only substance units: false
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium

metaR FAOXC102C101m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaM grdp x
boundary condition: false
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
is: SBO:0000247
constant: false
is: HMDB01285
name: geranyl diphosphate(3-)
is: CHEBI:58057
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species

metaM 3otdcoa m
constant: false
has only substance units: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
is: CHEBI:28726
initial concentration: 1.0
name: 3-Oxotetradecanoyl-CoA
initial amount: NaN
is: SBO:0000247
is: HMDB03935
boundary condition: false
type: Species

metaM cmpacna g
boundary condition: false
has only substance units: false
is: CHEBI:57812
type: Species
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB01176
name: CMP-N-acetyl-beta-neuraminate(2-)
is: SBO:0000247

metaM 5tedtricoa m
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
constant: false
type: Species
name: 5,8,11-tetradecatrienoylcoa
has only substance units: false
is: HMDB02288
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR r1617
reversible: true
kinetic law: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110011#
reactant: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaR FAOXC12C12OHm
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->OHC12)m
type: Reaction

metaM mercppyr c
is: SBO:0000247
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: 3-mercaptopyruvate
is: CHEBI:57678
type: Species
is: HMDB01368

http://identifiers.org/biomodels.db/MODEL1310110011#_f21c9a02_d8be_46ee_94d2_7498d892be45
constant: false
boundary condition: true
name: SYNJ1
is: SBO:0000252
is encoded by: hsa:8867
has only substance units: false
initial concentration: NaN
is: C9JFZ1
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_5f488d34_1a57_425f_91df_f1005cec8f4b
has only substance units: false
name: GCSH
is encoded by: hsa:2653
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is: P23434
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_7100c70e_74b9_4101_9472_e32b4bdbd182
initial amount: NaN
name: CPT1B
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1375
constant: false
has only substance units: false
is: Q53FV7
boundary condition: true
type: Species

metaR URCN
kinetic law: MODEL1310110011#
product: MODEL1310110011#
modifier: MODEL1310110011#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: URCN
is version of: http://identifiers.org/ec-code/4.2.1.49
is: SBO:0000176
reactant: MODEL1310110011#
is described by: ECO:0000269
reversible: false

metaR G14T10g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110011#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reactant: MODEL1310110011#
is: SBO:0000176
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#

metaM imp c
is: C00130
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: SBO:0000247
name: IMP
initial concentration: 1.0
is: HMDB00175
initial amount: NaN
type: Species
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:58053

metaR r1454
kinetic law: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
product: MODEL1310110011#
is: SBO:0000185
fast: false
reactant: MODEL1310110011#
reversible: false

metaM mi14p c
initial concentration: 1.0
is: SBO:0000247
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
is: CHEBI:58282
has only substance units: false
is: HMDB00968
type: Species
initial amount: NaN
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
constant: false
boundary condition: false

metaM gdp c
type: Species
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
boundary condition: false
is: C00035
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB01201
has only substance units: false
name: GDP
initial concentration: 1.0
is: CHEBI:58189

metaM malthp e
boundary condition: false
type: Species
is: C01936
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247
name: maltoheptaose
constant: false
has only substance units: false
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
initial concentration: 1.0
initial amount: NaN

metaR 4MOPt2im
fast: false
kinetic law: MODEL1310110011#
reversible: false
product: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
reactant: MODEL1310110011#
type: Reaction
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport

metaR r1618
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110011#
modifier: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
reactant: MODEL1310110011#
is: SBO:0000185

metaR FATP3t
kinetic law: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
fast: false
name: fatty acid electroneutral transport
modifier: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185

metaM pro L c
is: HMDB00162
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:17203
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
constant: false
is: SBO:0000247
type: Species
boundary condition: false
name: L-proline

metaR GDPFUCtg
name: GDPFuc Golgi transport via CMP antiport
is described by: ECO:0000269
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: true
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
fast: false
product: MODEL1310110011#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_b38994aa_fcc8_4d51_9ba1_69737362ed11
is encoded by: hsa:8704
has only substance units: false
initial concentration: NaN
name: B4GALT2
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial amount: NaN

metaR r2310
reactant: MODEL1310110011#
product: MODEL1310110011#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110011#
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110011#_0fb06546_90fc_4ff5_a594_a7f1b30c56d6
has only substance units: false
type: Species
is encoded by: hsa:3098
name: HK1
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is: Q59FD4

metaR RE1516M
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reactant: MODEL1310110011#
name: RE1516
fast: false
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.99.13
type: Reaction
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110011#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110011#_ac901d91_b9a9_4a6c_9635_65f8e21882fb
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:7915
has only substance units: false
boundary condition: true
is: Q546H9
initial concentration: NaN
name: ALDH5A1
type: Species

metaR r1619
reversible: true
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM vacccoa m
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
name: vaccenyl coenzyme A
is: http://identifiers.org/pubchem.compound/9543677
is: HMDB06521
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
boundary condition: false
constant: false

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_559f53c6_bf47_4423_879f_2d2291c69350
is encoded by: hsa:28232
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is: Q9UIG8
name: SLCO3A1
boundary condition: true

metaM cys L e
is: HMDB00574
initial amount: NaN
constant: false
name: L-cysteine
type: Species
is: SBO:0000247
is: CHEBI:17561
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
boundary condition: false

metaM nad c
is: CHEBI:57540
is: http://identifiers.org/pubchem.compound/3305
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C00003
initial amount: NaN
constant: false
type: Species
is: HMDB00902
name: Nicotinamide adenine dinucleotide
has only substance units: false

metaR DGCHOLtx
is described by: ECO:0000000
kinetic law: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
is: SBO:0000185
reversible: true
name: bile acid intracellular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_a0cfd204_4b85_4750_9363_3d0d9aeb1e8b
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5169
initial amount: NaN
name: ENPP3
is: Q308M7
type: Species
boundary condition: true

metaR P4508B13r
fast: false
modifier: MODEL1310110011#
name: sterol 12-alpha-hydroxylase (nadh)
is described by: ECO:0000269
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.14.13.95
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
type: Reaction
reactant: MODEL1310110011#

metaR r2315
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110011#
fast: false
product: MODEL1310110011#
reactant: MODEL1310110011#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r1612
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110011#
modifier: MODEL1310110011#
reversible: true
type: Reaction
product: MODEL1310110011#
is described by: ECO:0000000

metaM lneldccoa m
initial amount: NaN
constant: false
is: HMDB01064
initial concentration: 1.0
name: linoelaidyl coenzyme A
type: Species
is: http://identifiers.org/pubchem.compound/5462164
has only substance units: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
boundary condition: false
is: SBO:0000247

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_bfbbfe45_f261_417c_9bd5_a3ceaeff7afa
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:3417
is: O75874
name: IDH1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_31e9aeaf_73b3_41c4_b402_199d0ae6a72a
initial concentration: NaN
is: Q9Y2C5
has only substance units: false
boundary condition: true
name: SLC17A4
is encoded by: hsa:10050
initial amount: NaN
constant: false
is: SBO:0000252
type: Species

metaR G12MT2 L
reactant: MODEL1310110011#
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110011#
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_11faa989_65cb_415f_a4ea_ee83e1637961
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI971023
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: _AI971023_1_c

http://identifiers.org/biomodels.db/MODEL1310110011#_97e94454_a022_4520_b338_ffb8ceae80ad
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1962
initial amount: NaN
name: EHHADH
boundary condition: true
constant: false
is: SBO:0000252
is: Q9NY65

metaR HEXDICOAACBP
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioyl coa
type: Reaction

metaM pchol hs r
name: Phosphatidylcholine
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
initial amount: NaN
has only substance units: false
is: CHEBI:16110
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR DNDPt10m
kinetic law: MODEL1310110011#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110011#
name: dADP transport via dCDP antiport
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
product: MODEL1310110011#
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_c828d7a0_5045_43cb_9744_b7aa6cbe274d
is encoded by: hsa:11041
constant: false
type: Species
is: SBO:0000252
name: B3GNT1
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is: O43505

http://identifiers.org/biomodels.db/MODEL1310110011#_d632e72a_47ba_4ad0_b1ef_53753541383e
constant: false
is: SBO:0000252
boundary condition: true
type: Species
is: P22303
initial concentration: NaN
name: ACHE
is encoded by: hsa:43
has only substance units: false
initial amount: NaN

metaR r1613
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110011#
is: SBO:0000185
product: MODEL1310110011#
modifier: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110011#
type: Reaction

metaR r2316
product: MODEL1310110011#
reactant: MODEL1310110011#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110011#
fast: false

metaR SEBACIDTD
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacic acid into cytosol (diffusion)
type: Reaction

metaM q10 m
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: SBO:0000247
constant: false
boundary condition: false
name: ubiquinone-10
is: HMDB01072
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:46245

metaM hestratriol r
has only substance units: false
constant: false
name: 4,17 dihydroxy estradiol
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB05896

http://identifiers.org/biomodels.db/MODEL1310110011#_127bc8ed_06c6_40d4_ab2a_10575c131dcd
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: O95861
constant: false
is encoded by: hsa:10380
name: BPNT1
has only substance units: false
is: SBO:0000252

metaR r1453
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
kinetic law: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
reactant: MODEL1310110011#
reversible: true
product: MODEL1310110011#

metaR NADtx
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
product: MODEL1310110011#
kinetic law: MODEL1310110011#
name: transport of NAD into peroxisome
reversible: true
is: SBO:0000185

metaM sebcoa c
name: sebacoylcoa
initial amount: NaN
type: Species
boundary condition: false
is: HMDB13325
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR GALK
is version of: http://identifiers.org/ec-code/2.7.1.157
is version of: http://identifiers.org/ec-code/2.7.1.6
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110011#
fast: false
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
reversible: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#
name: galactokinase

metaR r0504
kinetic law: MODEL1310110011#
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
reversible: true
fast: false
is described by: ECO:0000000
modifier: MODEL1310110011#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.3.10
type: Reaction
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
product: MODEL1310110011#

metaR r2313
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110011#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
product: MODEL1310110011#
fast: false
reactant: MODEL1310110011#

metaR NDPK9n
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
product: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
is: SBO:0000176
fast: false
is described by: ECO:0000269
modifier: MODEL1310110011#
reversible: true
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
kinetic law: MODEL1310110011#

metaR r1614
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110011#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110011#
is: SBO:0000185
product: MODEL1310110011#

metaM sphs1p c
is: CHEBI:60119
is: HMDB00277
type: Species
is: SBO:0000247
boundary condition: false
name: sphingosine 1-phosphate(1-)
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_70392ff4_bf3e_43ea_85c7_a7adf1287dbd
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2974
name: GUCY1B2
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_061d5752_0451_4a75_bc97_aec1b2e3921e
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:W74642
initial amount: NaN
name: _W74642_1_c
type: Species
boundary condition: true
initial concentration: NaN

metaR r2314
product: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110011#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_35e889c5_53ac_40ea_9d27_ff5fc6315142
initial concentration: NaN
is encoded by: hsa:3613
initial amount: NaN
is: O14732
constant: false
is: SBO:0000252
type: Species
boundary condition: true
name: IMPA2
has only substance units: false

metaM akg m
constant: false
type: Species
is: C00026
boundary condition: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16810
is: HMDB00208
name: 2-Oxoglutarate

metaR r1615
modifier: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110011#
is described by: ECO:0000000

metaR TETTET6t
reactant: MODEL1310110011#
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
type: Reaction
name: fatty acid transport via diffusion

metaM gdp n
initial amount: NaN
name: GDP(3-)
type: Species
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB01201
boundary condition: false
initial concentration: 1.0
is: CHEBI:58189

metaR 34HPPte
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
name: Transport of 3-(4-hydroxyphenyl)pyruvate
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_7c8ed658_ba40_426a_91a9_222a4b8a7f4a
is: SBO:0000252
is: P43353
name: ALDH3B1
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:221
constant: false
has only substance units: false

metaR RE2655R
name: RE2655
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
product: MODEL1310110011#
is: SBO:0000176
reactant: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#

metaM tchola x
initial amount: NaN
name: taurocholate
initial concentration: 1.0
is: HMDB00036
constant: false
boundary condition: false
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
type: Species
is: CHEBI:36257
is: SBO:0000247
has only substance units: false

metaR ACt2r
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
is: SBO:0000185
type: Reaction
name: acetate reversible transport via proton symport
product: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
is described by: ECO:0000000
reversible: true

metaM imp e
is: SBO:0000247
boundary condition: false
is: HMDB00175
type: Species
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
has only substance units: false
name: IMP(2-)
is: CHEBI:58053
constant: false
initial concentration: 1.0
initial amount: NaN

metaR BDHm
fast: false
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.30
modifier: MODEL1310110011#
is: SBO:0000176
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110011#_d998e343_fad5_487a_801e_af03851dfd58
initial concentration: NaN
initial amount: NaN
constant: false
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has only substance units: false
boundary condition: true
is encoded by: hsa:51227
is: SBO:0000297
type: Species

metaR r0660
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
is described by: ECO:0000000
fast: false
type: Reaction
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.5.1.2
reversible: true
reactant: MODEL1310110011#

metaR r0818
is described by: ECO:0000000
reactant: MODEL1310110011#
name: Transport reaction
product: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110011#_48f135a7_fe28_4c17_8577_7c1e3461e9c7
initial concentration: NaN
is encoded by: hsa:J03866
has only substance units: false
is: SBO:0000252
constant: false
name: _J03866_1_m
boundary condition: true
initial amount: NaN
type: Species

metaM sphs1p e
is: HMDB00277
constant: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:60119
is: SBO:0000247
initial concentration: 1.0
name: sphingosine 1-phosphate(1-)

metaM pro L m
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00162
name: L-proline
is: CHEBI:17203
initial concentration: 1.0
has only substance units: false

metaR VALTA
product: MODEL1310110011#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.6.1.42
fast: false
name: valine transaminase
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
is described by: ECO:0000269

metaM gdp m
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial amount: NaN
is: HMDB01201
boundary condition: false
has only substance units: false
is: SBO:0000247
name: GDP
type: Species
constant: false
is: CHEBI:58189
is: C00035
initial concentration: 1.0

metaM L2aadp6sa c
has only substance units: false
is: CHEBI:17917
is: SBO:0000247
type: Species
name: L-allysine
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB01263

metaM prostgd2 c
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
type: Species
has only substance units: false
constant: false
is: HMDB01403
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: prostaglandin D2(1-)
is: CHEBI:57406

metaR r2319
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110011#
reactant: MODEL1310110011#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction

metaR C180CPT1
reactant: MODEL1310110011#
modifier: MODEL1310110011#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
notes: GENE_ASSOCIATION: (1375.4) or (1375.2) or (126129.1) or (1375.1) or (1374.1) or (1375.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TV (see C160CRN)
type: Reaction
product: MODEL1310110011#
is: SBO:0000176
name: production of stearoylcarnitine

http://identifiers.org/biomodels.db/MODEL1310110011#_a5de7ad5_ef07_4557_a031_17a55533ae76
initial concentration: NaN
boundary condition: true
name: SLC35A2
type: Species
initial amount: NaN
is: P78381
is encoded by: hsa:7355
constant: false
is: SBO:0000252
has only substance units: false

metaM xoltetrol m
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
has only substance units: false
is: HMDB01231
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
initial amount: NaN
is: CHEBI:17278
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446

metaR r0817
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000185
type: Reaction
reversible: true
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.41
is described by: ECO:0000000
product: MODEL1310110011#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2

metaR RE0452M
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110011#
kinetic law: MODEL1310110011#
name: RE0452
reactant: MODEL1310110011#

metaM ethamp c
initial concentration: 1.0
is: HMDB00224
is: SBO:0000247
is: CHEBI:58190
name: ethamp[c]
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
boundary condition: false
constant: false

metaR r0509
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110011#
product: MODEL1310110011#
type: Reaction
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
is described by: ECO:0000000
fast: false
reversible: false

metaM HC01104 e
constant: false
initial concentration: 1.0
has only substance units: false
name: 4-nitrophenyl phosphate(2-)
is: SBO:0000247
is: CHEBI:61146
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
type: Species

metaM 2mb2coa m
has only substance units: false
constant: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
name: 2-methylcrotonoyl-CoA(4-)
is: HMDB02054
initial concentration: 1.0
boundary condition: false
is: CHEBI:57337
initial amount: NaN
is: SBO:0000247
type: Species

metaM estradiol r
initial amount: NaN
type: Species
is: HMDB00151
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
name: estradiol
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:16469
constant: false

metaM vacccoa c
is: SBO:0000247
has only substance units: false
is: HMDB06521
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
constant: false
name: vaccenyl coenzyme A
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/9543677

http://identifiers.org/biomodels.db/MODEL1310110011#_311d3f1b_7ac6_4dfe_a9a1_ec8644ecf981
is: SBO:0000252
has only substance units: false
is encoded by: hsa:7378
boundary condition: true
constant: false
type: Species
is: Q16831
initial concentration: NaN
initial amount: NaN
name: UPP1

metaR FADDPle
name: FAD diphosphatase
reversible: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (5167.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000176
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
modifier: MODEL1310110011#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.1
product: MODEL1310110011#

metaR ACt2m
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110011#
name: acetate mitochondrial transport via proton symport
reactant: MODEL1310110011#
reversible: true
kinetic law: MODEL1310110011#
type: Reaction

metaM coa c
constant: false
initial amount: NaN
is: SBO:0000247
name: Coenzyme A
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
is: HMDB01423
boundary condition: false
is: C00010
is: CHEBI:3312

metaM utp c
name: UTP
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00285
is: C00075
is: CHEBI:46398
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075

metaM maltpt e
initial amount: NaN
has only substance units: false
boundary condition: false
name: maltopentaose
type: Species
initial concentration: 1.0
is: C02052
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5141
is: HMDB01296
constant: false

metaR r1610
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110011#
is: SBO:0000185
reversible: true
reactant: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110011#

metaM mn l
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
initial concentration: 1.0
boundary condition: false
name: beta-1,4-mannose-N-acetylglucosamine
is: SBO:0000247
type: Species
is: HMDB06535
has only substance units: false
initial amount: NaN
constant: false

metaM dha e
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
is: HMDB01882
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:16016
name: glycerone

http://identifiers.org/biomodels.db/MODEL1310110011#_d08c7c5c_7e01_4752_b8ad_5684b556ceb0
is encoded by: hsa:55350
is encoded by: hsa:8875
has part: O95497
is: SBO:0000297
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
is encoded by: hsa:8876
initial concentration: NaN
name: VNN3:VNN2:VNN1
has part: A8K7W0

http://identifiers.org/biomodels.db/MODEL1310110011#_8f18d6de_ec83_4674_9d2d_e3046e1a2887
type: Species
initial concentration: NaN
is: O14880
is encoded by: hsa:4259
has only substance units: false
constant: false
name: MGST3
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR r2317
reactant: MODEL1310110011#
fast: false
type: Reaction
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110011#
is: SBO:0000185

metaR GMAND
is: SBO:0000176
notes: GENE_ASSOCIATION: (2762.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.2.1.47 Confidence Level: 0 AUTHORS: NOTES:JLR
fast: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000000
name: GDP-D-mannose dehydratase
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.47
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110011#_f0af7eab_176d_4b62_8931_84918f56399c
initial amount: NaN
constant: false
is: Q9H903
name: MTHFD2L
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:441024

http://identifiers.org/biomodels.db/MODEL1310110011#_ded160a2_ff68_4f84_b331_d2c9c30f3396
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
name: DLD
is: SBO:0000252
is encoded by: hsa:1738
constant: false
boundary condition: true
is: P09622

metaM cmpacna n
is: SBO:0000247
is: CHEBI:57812
has only substance units: false
type: Species
name: CMP-N-acetyl-beta-neuraminate(2-)
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial concentration: 1.0
is: HMDB01176
initial amount: NaN
constant: false
boundary condition: false

metaR r1611
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110011#
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaR r2318
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110011#
fast: false
reversible: true
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction

metaR C180CPT2
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110011#
name: carnitine O-stearoyl transferase
modifier: MODEL1310110011#
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110011#
is: SBO:0000176

metaR r1088
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
name: Active transport
product: MODEL1310110011#
is: SBO:0000185
reversible: true
fast: false

metaR GLCt4
reversible: true
is: SBO:0000185
name: glucose transport via sodium symport
fast: false
type: Reaction
product: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
modifier: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000269

metaR HPYRR2x
notes: GENE_ASSOCIATION: (3948.1) or (197257.1) or (3945.1) or (160287.1) or (3945.1 and 3939.1) or (92483.1) or (3939.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:14635115,PMID:5635456 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.27
fast: false
type: Reaction
modifier: MODEL1310110011#
name: hydroxypyruvate reductase (NADH)
reactant: MODEL1310110011#
is described by: ECO:0000304
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.2.4
kinetic law: MODEL1310110011#
product: MODEL1310110011#

metaR r1595
product: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110011#
reversible: true
kinetic law: MODEL1310110011#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_a724a8ab_9c26_42d4_9393_8576217340e4
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: ALG3
initial concentration: NaN
is encoded by: hsa:10195

metaR FAOXC226C205m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

metaR r0730
modifier: MODEL1310110011#
reversible: false
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110011#
is described by: ECO:0000000
reactant: MODEL1310110011#
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110011#

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_677a2ebb_c01d_485a_b5f9_ca1f92226277
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: B2RAT6
name: GALT
is encoded by: hsa:2592
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_ca0dfe9b_1cd7_478f_9503_26a7af652ae4
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false
is: O94777
name: DPM2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8818

metaR ACALDt
product: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
name: acetaldehyde reversible transport
type: Reaction

metaM pyr c
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:15361
name: pyruvate
has only substance units: false
constant: false
is: C00022
is: HMDB00243
initial amount: NaN
notes: FORMULA: C3H3O3 CHARGE: -1
boundary condition: false
is: http://identifiers.org/pubchem.compound/3324

metaR MI1345PP
is version of: http://identifiers.org/ec-code/3.1.3.86
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
reactant: MODEL1310110011#
fast: false
modifier: MODEL1310110011#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.36
kinetic law: MODEL1310110011#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.56
product: MODEL1310110011#

metaM retinal r
type: Species
is: CHEBI:15035
boundary condition: false
name: retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
is: HMDB01358
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR q10h2tc
is described by: ECO:0000134
type: Reaction
fast: false
reactant: MODEL1310110011#
reversible: true
is: SBO:0000185
name: transport of ubiquinol into cytosol
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110011#
product: MODEL1310110011#

metaR r1596
product: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaM taur c
notes: FORMULA: C2H7NO3S CHARGE: 0
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: C00245
has only substance units: false
name: Taurine
is: CHEBI:3544
is: HMDB00251

http://identifiers.org/biomodels.db/MODEL1310110011#_ed581b7e_7d7f_4ae8_8fe4_d36aeb96e450
name: GALT
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: B2RAT6
type: Species
boundary condition: true
is encoded by: hsa:2592
is: SBO:0000252
constant: false

metaM gltcho e
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C1200026H2200045NO1100007S CHARGE: 0
name: beta glucan-taurocholic acid complex
has only substance units: false
is: HMDB00893
constant: false
type: Species

metaR ASCBt4
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
type: Reaction
is described by: ECO:0000269
fast: false
product: MODEL1310110011#
name: L-ascorbate transport via proton symport
is: SBO:0000185
reactant: MODEL1310110011#
reversible: true

metaM clpnd e
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
name: clupanodonic acid
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:53488
has only substance units: false
is: HMDB06528

http://identifiers.org/biomodels.db/MODEL1310110011#_d94f975a_b056_4e61_b9b0_c34b2d8b3a9d
name: CA12
type: Species
boundary condition: true
is: O43570
is encoded by: hsa:771
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR G14Tg
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
type: Reaction
is: SBO:0000176
reversible: false
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR HMGCOASim
is described by: ECO:0000269
type: Reaction
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
modifier: MODEL1310110011#
name: Hydroxymethylglutaryl CoA synthase (ir)
fast: false
is version of: http://identifiers.org/ec-code/2.3.3.10
reversible: false
kinetic law: MODEL1310110011#
is: SBO:0000176
reactant: MODEL1310110011#

metaM 5dpmev x
initial concentration: 1.0
has only substance units: false
is: CHEBI:15899
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00685 EHMN_ABBREVIATION: C01143
is: HMDB01090
name: (R)-5-Diphosphomevalonate
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
constant: false

metaR r1597
product: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaR RE1523M
is: SBO:0000176
name: RE1523
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110011#
type: Reaction

metaR RETI2
is: SBO:0000176
name: retinol isomerase (9-cis)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110011#
product: MODEL1310110011#
fast: false
reversible: true
reactant: MODEL1310110011#

metaR r0732
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110011#
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110011#
is: SBO:0000176
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
product: MODEL1310110011#

metaR r1019
is: SBO:0000185
fast: false
name: Postulated transport reaction
reactant: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
product: MODEL1310110011#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_99b96789_69e8_475b_9eb0_7fe3c5128d3f
boundary condition: true
initial amount: NaN
is: Q9UHW9
name: SLC12A6
is: SBO:0000252
is encoded by: hsa:9990
type: Species
constant: false
has only substance units: false
initial concentration: NaN

metaR r0627
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
reversible: true
product: MODEL1310110011#
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
kinetic law: MODEL1310110011#
is described by: ECO:0000000
reactant: MODEL1310110011#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_e673d7df_6722_405b_a739_ebe28474fe64
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: GLRX2
constant: false
type: Species
has only substance units: false
is encoded by: hsa:51022

http://identifiers.org/biomodels.db/MODEL1310110011#_31d8aadc_af26_4e80_bc6c_78b0255d5830
is: P19404
initial amount: NaN
is encoded by: hsa:4729
boundary condition: true
type: Species
name: NDUFV2
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252

metaR MAN6PI
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
fast: false
name: mannose-6-phosphate isomerase
modifier: MODEL1310110011#
is: SBO:0000176
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000304
type: Reaction
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/5.3.1.8
reversible: true

metaM pyr e
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
name: pyruvate
has only substance units: false
is: CHEBI:15361
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: HMDB00243

metaR EX tetpent6 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-6 exchange
type: Reaction

metaM taur e
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
name: Taurine
constant: false
initial amount: NaN
notes: FORMULA: C2H7NO3S CHARGE: 0
is: HMDB00251
is: C00245
is: CHEBI:3544
boundary condition: false

metaR C80CPT1
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of octanoylcarnitine
type: Reaction

metaM nh4 m
boundary condition: false
has only substance units: false
is: SBO:0000247
name: Ammonium
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00051
is: CHEBI:28938
is: C01342
constant: false

metaM glu L m
is: SBO:0000247
is: HMDB00148
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial amount: NaN
type: Species
is: CHEBI:29985
boundary condition: false
name: L-glutamate(1-)

http://identifiers.org/biomodels.db/MODEL1310110011#_64a2dfdd_641e_4868_bd9f_32e0d54fd682
is encoded by: hsa:55293
constant: false
type: Species
name: UEVLD
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q8IX04

metaR ASNGLNNaEx
modifier: MODEL1310110011#
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110011#
is: SBO:0000185
kinetic law: MODEL1310110011#
product: MODEL1310110011#

metaR r1018
reversible: true
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is: SBO:0000185
name: Transport reaction
type: Reaction
product: MODEL1310110011#
fast: false

metaR r0731
is: SBO:0000176
reactant: MODEL1310110011#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000000
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction

metaR r1598
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110011#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r1591
product: MODEL1310110011#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185

metaR SERLYSNaex
is described by: ECO:0000212
reactant: MODEL1310110011#
name: Serine/Lysine Na-dependent exchange (Ser in)
type: Reaction
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9056.1 and 6519.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
reversible: false
modifier: MODEL1310110011#

metaM mgacpail hs r
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
is: HMDB00220
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C00249
type: Species
is: CHEBI:7896
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
constant: false

metaR FACOAL2252
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
name: fatty-acid--CoA ligase
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

metaM arab L c
initial amount: NaN
initial concentration: 1.0
name: L-arabinose
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0
is: HMDB00646
type: Species
has only substance units: false
is: CHEBI:30849
constant: false

metaR r0629
type: Reaction
modifier: MODEL1310110011#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.22
fast: false
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
reversible: true
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.1.4.1
reactant: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#

metaM val L c
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16414
has only substance units: false
is: HMDB00883
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
name: L-valine

metaR r1592
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
product: MODEL1310110011#
fast: false
reactant: MODEL1310110011#

metaM ttdcrn c
boundary condition: false
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
constant: false
is: SBO:0000247
type: Species
name: tetradecanoyl carnitine
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB05066
is: http://identifiers.org/pubchem.compound/3413344

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaM gpail hs c
initial concentration: 1.0
is: SBO:0000247
type: Species
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
has only substance units: false
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
constant: false
boundary condition: false
is: CHEBI:17049
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_7dd22699_3f6b_41cf_8849_5825df0bd67c
name: LDHC
type: Species
initial concentration: NaN
is encoded by: hsa:3948
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false

metaR FACOAL2251
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110011#
fast: false
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110011#_0aac977d_a72b_4a70_b0e3_160de77ecf27
name: _AI620219_1_e
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:AI620219
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252

metaM phytcoa x
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:57391
name: phytanoyl-CoA(4-)
boundary condition: false
has only substance units: false
is: HMDB01359
constant: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1

metaR NDP7g
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.6.1.6
name: nucleoside-diphosphatase (UDP), Golgi apparatus
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
reversible: false
is: SBO:0000176
type: Reaction
product: MODEL1310110011#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_377d7d42_f9ec_4606_b931_a49731bf7898
type: Species
name: CA4
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:762
is: Q6FHI7
constant: false
initial concentration: NaN

metaR ILEt5m
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: true
name: Isoleucine mitochondrial transport
is described by: ECO:0000000
product: MODEL1310110011#
is: SBO:0000185
type: Reaction

metaR M8MASNterg
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11007802 NOTES:NCD
kinetic law: MODEL1310110011#
reversible: false
product: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000185
name: m8masn transport from ER to Golgi apparatus
type: Reaction

metaR DASCBR
modifier: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.8.4.1
is described by: ECO:0000269
name: dehydroascorbate reductase
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
kinetic law: MODEL1310110011#
product: MODEL1310110011#

metaM HC01712 m
initial concentration: 1.0
name: S-Glutaryldihydrolipoamide
type: Species
is: CHEBI:28391
notes: FORMULA: C13H22NO4S2 CHARGE: -1 INCHI: InChI=1S/C13H23NO4S2/c14-11(15)5-2-1-4-10(19)8-9-20-13(18)7-3-6-12(16)17/h10,19H,1-9H2,(H2,14,15)(H,16,17) EHMN_ABBREVIATION: C06157
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM e4p c
initial amount: NaN
is: C00279
is: CHEBI:16897
initial concentration: 1.0
is: HMDB01321
name: D-Erythrose 4-phosphate
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
is: SBO:0000247
constant: false
type: Species
boundary condition: false
has only substance units: false

metaR r1593
product: MODEL1310110011#
is described by: ECO:0000000
reactant: MODEL1310110011#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110011#
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR SUCD1m
is: SBO:0000176
name: succinate dehydrogenase
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/1.3.5.1
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction
product: MODEL1310110011#
modifier: MODEL1310110011#
reversible: true

metaM glu L r
name: L-glutamate(1-)
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:29985
is: SBO:0000247
boundary condition: false
constant: false
type: Species
is: HMDB00148

http://identifiers.org/biomodels.db/MODEL1310110011#_15ede5d1_0741_4b83_87d8_ba16b812ae7c
initial amount: NaN
name: AKR1C1
type: Species
is encoded by: hsa:1645
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: Q04828
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_b0966648_505f_44d3_8a2b_b3ed42e46e75
initial amount: NaN
constant: false
is: P11310
is encoded by: hsa:34
name: ACADM
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaR NDPK1
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110011#
is described by: ECO:0000134
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: nucleoside-diphosphate kinase (ATP:GDP)
modifier: MODEL1310110011#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR BTNt4i
name: Biotin uptake (antiport)
reactant: MODEL1310110011#
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
reversible: false
type: Reaction
is described by: ECO:0000269
fast: false
is: SBO:0000185
kinetic law: MODEL1310110011#
product: MODEL1310110011#

metaM arab L e
initial amount: NaN
type: Species
boundary condition: false
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0
is: HMDB00646
initial concentration: 1.0
has only substance units: false
name: L-arabinose
is: CHEBI:30849
is: SBO:0000247

metaM glu5sa m
is: C01165
has only substance units: false
is: HMDB02104
is: CHEBI:17232
type: Species
name: L-Glutamate 5-semialdehyde
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM 3octpencoa m
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
boundary condition: false
constant: false
name: 3,6,9,12,15-octadecapentenoylcoa
initial amount: NaN
type: Species
is: HMDB06294
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_86023737_af91_4e06_b360_0c2dc540e949
is: Q9BV79
boundary condition: true
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:51102
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: MECR

metaM val L e
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:16414
initial concentration: 1.0
is: HMDB00883
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
constant: false
name: L-valine

metaR FAOXC10DCC8DCx
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10DC-->C8DC)
type: Reaction

metaR r1594
is described by: ECO:0000000
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110011#

metaR CYTDK1
kinetic law: MODEL1310110011#
is described by: ECO:0000254
reversible: false
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.1.48
modifier: MODEL1310110011#
name: ATPcytidine 5-phosphotransferase
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
fast: false
reactant: MODEL1310110011#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_f85dea5e_b94e_46f2_8e10_22d4d3aa7f63
boundary condition: true
constant: false
is: Q549M5
is encoded by: hsa:4718
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: NDUFC2

metaR RE3568C
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
name: RE3568
product: MODEL1310110011#
fast: false
is: SBO:0000176
type: Reaction

metaR r0202
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
reversible: true
type: Reaction
is: SBO:0000176
product: MODEL1310110011#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_dbb96446_a598_4ad5_87b3_c7e87fde4fce
is: C9JZ62
has only substance units: false
is encoded by: hsa:641649
type: Species
constant: false
boundary condition: true
initial concentration: NaN
name: TMEM91
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_ffc6297f_5179_475b_923c_0cfff574b46c
name: GPX2
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is: P18283
is encoded by: hsa:2877
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_dff155c2_60c4_4962_926e_bab124a0e2be
name: PANK1
initial amount: NaN
constant: false
is: Q8TE04
is encoded by: hsa:53354
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_1586db69_111b_4ba5_b985_2530bcaa5591
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
name: ODC1
is: P11926
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4953

metaM xylu L c
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
name: L-xylulose
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00751
is: CHEBI:17399
type: Species
constant: false

metaM thbpt c
initial amount: NaN
is: CHEBI:15372
is: HMDB00027
boundary condition: false
initial concentration: 1.0
constant: false
name: 5,6,7,8-tetrahydrobiopterin
type: Species
has only substance units: false
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
is: SBO:0000247

metaR FAOXC204184m
fast: false
name: Beta oxidation fatty acid
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110011#
reactant: MODEL1310110011#
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 rounds of beta ox c20:4 -> c18:4 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110011#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110011#_29dd6144_03b0_4a8b_8fcb_b296f9dad1e7
name: NDUFA9
boundary condition: true
type: Species
is: Q16795
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:4704

metaR EX 4pyrdx LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Pyridoxate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_98b1c9c7_4693_41ad_98e3_c46989c7c3f3
type: Species
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
name: _728637_1_c
initial concentration: NaN
is encoded by: hsa:728637

metaM dhap x
has only substance units: false
is: HMDB01473
is: CHEBI:57642
is: http://identifiers.org/pubchem.compound/3411
constant: false
initial concentration: 1.0
is: SBO:0000247
is: C00111
name: Dihydroxyacetone phosphate
type: Species
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_d56cf7ac_2f0a_4dc9_8cdd_6a1d05f5accb
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: P07195
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3945
boundary condition: true
name: LDHB

http://identifiers.org/biomodels.db/MODEL1310110011#_ed14f147_2148_419f_ba3b_915e8e9b3950
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:220
is: P47895
boundary condition: true
constant: false
name: ALDH1A3
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_3a6e1b4d_7cbe_427f_b603_f31b56deb905
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaR RE3009C
product: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110011#
name: RE3009
is: SBO:0000176
kinetic law: MODEL1310110011#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_a8acf29f_8e51_4ab4_b198_8a99ecfed376
is encoded by: hsa:377677
is: SBO:0000252
is: Q8N1Q1
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
name: CA13

metaR RE1534M
is: SBO:0000176
is described by: ECO:0000000
name: RE1534
fast: false
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
type: Reaction

metaR NODe
fast: false
is described by: ECO:0000134
product: MODEL1310110011#
is: SBO:0000185
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
name: NODe
kinetic law: MODEL1310110011#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110011#_e8230d2c_7ef4_4fa5_a4e9_96373eac3fc4
name: NDUFS4
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:4724
is: SBO:0000252
is: O43181
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_869028f2_9fd3_4b4e_83f7_f521735eea9b
is: SBO:0000252
is: Q99807
has only substance units: false
initial amount: NaN
is encoded by: hsa:10229
name: COQ7
initial concentration: NaN
type: Species
constant: false
boundary condition: true

metaR GALt4
is: SBO:0000185
kinetic law: MODEL1310110011#
type: Reaction
is described by: ECO:0000269
name: galactose transport via sodium symport
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
modifier: MODEL1310110011#
reversible: true
reactant: MODEL1310110011#
product: MODEL1310110011#
fast: false

metaM hLkynr c
name: 3-hydroxy-L-kynurenine
has only substance units: false
is: HMDB11631
initial concentration: 1.0
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:17380
type: Species
is: SBO:0000247

metaR MANtly
type: Reaction
kinetic law: MODEL1310110011#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110011#
fast: false
name: mannose efflux from lysosome
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_6af7b919_b352_42ce_96cf_8f28f48dcd50
constant: false
is encoded by: hsa:53
has only substance units: false
initial concentration: NaN
type: Species
name: ACP2
is: E9PCI1
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM 2mp2coa m
constant: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
is: HMDB01011
boundary condition: false
type: Species
name: 2-Methylprop-2-enoyl-CoA
is: CHEBI:27754
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

metaM tetd7ecoa m
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB13109
constant: false
name: 7-tetradecenoylcoa
type: Species
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
has only substance units: false

metaR 4HGLSDm
is version of: http://identifiers.org/ec-code/1.5.1.12
reactant: MODEL1310110011#
fast: false
type: Reaction
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
kinetic law: MODEL1310110011#
is described by: ECO:0000212
is: SBO:0000176
reversible: true
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
product: MODEL1310110011#

metaR r0974
product: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110011#
reversible: true
type: Reaction
is: SBO:0000185
name: Active transport

metaM hestratriol e
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: HMDB05896
initial concentration: 1.0
type: Species
name: 4,17 dihydroxy estradiol
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1

metaM xtsn c
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
constant: false
is: CHEBI:18107
is: SBO:0000247
is: HMDB00299
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: xanthosine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_e8772402_298f_4bc0_bcfd_b02b13dfa7b1
has only substance units: false
boundary condition: true
is encoded by: hsa:22305
constant: false
type: Species
initial amount: NaN
name: _22305_1_c
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_45933f6b_b266_4631_aa16_e1d4852374e0
initial amount: NaN
initial concentration: NaN
is: Q5MY95
name: ENTPD8
has only substance units: false
constant: false
is encoded by: hsa:377841
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_425e68ca_2a37_418f_a6d6_38bd1f2e4058
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5139
constant: false
type: Species
initial amount: NaN
boundary condition: true
name: PDE3A
is: Q14432
has only substance units: false

metaR r0311
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.9
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110011#
product: MODEL1310110011#
fast: false
reversible: false
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110011#
is described by: ECO:0000000

metaM ala L e
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:16977
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial concentration: 1.0
name: L-alanine
is: HMDB00161

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

metaR FACOAL1813
is: SBO:0000176
modifier: MODEL1310110011#
is described by: ECO:0000269
kinetic law: MODEL1310110011#
reversible: true
product: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
name: fatty-acid--CoA ligase

metaM arachcoa c
initial amount: NaN
is: HMDB04258
type: Species
boundary condition: false
is: CHEBI:15527
name: arachidyl coenzyme A
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041

metaR r0973
fast: false
name: Facilitated diffusion
kinetic law: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_30d73296_9f4a_4cee_8dbc_692f8a35c875
is encoded by: hsa:4830
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: NaN
has part: P22392
boundary condition: true
name: NME1:NME2
has part: P15531
is: SBO:0000297
is encoded by: hsa:4831

metaM nh4 e
name: ammonium
type: Species
constant: false
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
has only substance units: false
is: CHEBI:28938
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM pyr m
is: HMDB00243
initial amount: NaN
type: Species
name: pyruvate
constant: false
is: CHEBI:15361
boundary condition: false
is: SBO:0000247
is: C00022
is: http://identifiers.org/pubchem.compound/3324
has only substance units: false
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
initial concentration: 1.0

metaR r1010
product: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
type: Reaction
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110011#
reversible: true

metaM lnlncg e
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
type: Species
boundary condition: false
is: CHEBI:32391
is: SBO:0000247
initial concentration: 1.0
is: HMDB03073
initial amount: NaN
name: gamma-linolenate
has only substance units: false

metaR FAOXC14DCC12DCx
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14DC-->C12DC)x
type: Reaction

metaM dctp c
type: Species
initial amount: NaN
is: CHEBI:16311
has only substance units: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: SBO:0000247
boundary condition: false
is: HMDB00998
constant: false
name: dCTP
initial concentration: 1.0
is: C00458

metaR FAOXC204C184m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_c8803db3_f45c_4386_bda6_5025d62b2da3
is: SBO:0000297
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:4830
type: Species
boundary condition: true
initial concentration: NaN
name: NME1:NME2

metaR r0734
fast: false
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110011#
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110011#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110011#

metaR r1017
name: Vesicular transport
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12663868,PMID:14716480,PMID:15209530,PMID:15297262,PMID:1599411,PMID:17416343,PMID:9068608 NOTES:
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
reversible: false

metaR r1599
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110011#
is: SBO:0000185
reversible: true
product: MODEL1310110011#
kinetic law: MODEL1310110011#

metaM CE5161 r
constant: false
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:12947
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110011#_4fb18fac_099f_4bfd_98a0_d7438b20f9f5
is encoded by: hsa:5148
is: P18545
initial concentration: NaN
name: PDE6G
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true

metaM hestratriol c
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB05896
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
constant: false
name: 4,17 dihydroxy estradiol
boundary condition: false
is: SBO:0000247

metaR ACACt2m
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
fast: false
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
modifier: MODEL1310110011#
reactant: MODEL1310110011#
name: Acetoacetate mitochondrial transport via H+ symport

http://identifiers.org/biomodels.db/MODEL1310110011#_059cbc46_2c18_4be2_a889_4da3d4d76a90
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10678
has only substance units: false
boundary condition: true
name: B3GNT2

http://identifiers.org/biomodels.db/MODEL1310110011#_07a1b200_3c81_46ce_9304_0440db096fb3
has only substance units: false
is: O60547
initial concentration: NaN
is encoded by: hsa:2762
type: Species
is: SBO:0000252
name: GMDS
constant: false
initial amount: NaN
boundary condition: true

metaR FACOAL1812
fast: false
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
product: MODEL1310110011#
is: SBO:0000176
modifier: MODEL1310110011#
is described by: ECO:0000000
reversible: true
name: fatty-acid--CoA ligase

http://identifiers.org/biomodels.db/MODEL1310110011#_51233bc3_f8d5_4c39_8bc3_e26cf8cf43cd
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
has only substance units: false
name: SDHA
initial concentration: NaN
is: P31040
is encoded by: hsa:6389

metaM ala L c
has only substance units: false
is: HMDB00161
is: CHEBI:16977
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
boundary condition: false
name: L-alanine

metaM 2hb c
is: HMDB00008
name: 2-Hydroxybutyrate
type: Species
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
initial concentration: 1.0
is: CHEBI:1148
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false

metaM 2mop m
has only substance units: false
is: HMDB01172
boundary condition: false
initial concentration: 1.0
name: 2-methyl-3-oxopropanoate
is: SBO:0000247
constant: false
is: CHEBI:57700
initial amount: NaN
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349

metaM hdcea r
name: palmitoleate
is: HMDB03229
is: CHEBI:32372
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
type: Species
constant: false

metaR r0733
is: SBO:0000176
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: false
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
modifier: MODEL1310110011#
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.12
type: Reaction

metaM gly c
type: Species
name: Glycine
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0
is: SBO:0000247
is: HMDB00123
is: C00037
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:3339

http://identifiers.org/biomodels.db/MODEL1310110011#_7338fb4f_8427_44e0_a57e_0085389cd338
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: ALDH1A2
initial amount: NaN
is encoded by: hsa:8854
type: Species
boundary condition: true
constant: false
is: B4DZR2

metaM ddece1crn e
constant: false
type: Species
is: C02838
has only substance units: false
is: HMDB00791
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: dodecenoyl carnitine
notes: FORMULA: C19H35NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110011#_53fc5398_c4c8_49e0_8713_b9eb454ea399
initial amount: NaN
name: SLCO1B1
is: SBO:0000252
has only substance units: false
is: Q9Y6L6
initial concentration: NaN
constant: false
is encoded by: hsa:10599
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_00be964d_c36b_4751_adc4_0751bf2db28a
is: P14672
initial concentration: NaN
name: SLC2A4
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:6517
type: Species
is: SBO:0000252

metaM lnlncg c
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
initial concentration: 1.0
is: CHEBI:32391
is: SBO:0000247
constant: false
is: HMDB03073
type: Species
initial amount: NaN
has only substance units: false
name: gamma-linolenate

metaM HC02179 c
is: CHEBI:34306
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: 20-hydroxy-arachidonate
constant: false
type: Species
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial amount: NaN
has only substance units: false

metaM nh4 c
is: C01342
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00051
boundary condition: false
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
is: SBO:0000247
name: Ammonium

http://identifiers.org/biomodels.db/MODEL1310110011#_6338c32d_62d1_4aaa_bb46_c2442b21f01f
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
is: B7Z2M9
is encoded by: hsa:8525
has only substance units: false
boundary condition: true
initial concentration: NaN
name: DGKZ

http://identifiers.org/biomodels.db/MODEL1310110011#_5cf6ad62_c91c_4dc9_9251_3d2ea7d48d9b
is encoded by: hsa:2530
boundary condition: true
is: Q9BYC5
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
constant: false
name: FUT8

http://identifiers.org/biomodels.db/MODEL1310110011#_c927f57b_3aac_4bdb_a024_9961229ec725
initial amount: NaN
is encoded by: hsa:2348
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial concentration: NaN
boundary condition: true
name: FOLR1

metaR PDE1
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.1.4.17
fast: false
kinetic law: MODEL1310110011#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.4.35
type: Reaction
reactant: MODEL1310110011#
reversible: false
name: 3',5'-cyclic-nucleotide phosphodiesterase
product: MODEL1310110011#

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_68b73a7f_7243_4fb9_9960_af7bc0ecb449
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:23600
initial amount: NaN
initial concentration: NaN
is: Q9UHK6
name: AMACR
is: SBO:0000252

metaR TMDS
kinetic law: MODEL1310110011#
name: thymidylate synthase
fast: false
notes: GENE_ASSOCIATION: (7298.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.1.1.45 Confidence Level: 4 AUTHORS: PMID:14967037,PMID:2243092 NOTES:
is version of: http://identifiers.org/ec-code/2.1.1.45
is: SBO:0000176
type: Reaction
product: MODEL1310110011#
is described by: ECO:0000269
reactant: MODEL1310110011#
reversible: false
modifier: MODEL1310110011#

metaR G14T9g
reversible: false
fast: false
kinetic law: MODEL1310110011#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.4.1.38

metaM itp c
is: SBO:0000247
constant: false
boundary condition: false
name: ITP(3-)
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: HMDB00189
type: Species
is: CHEBI:57614

metaM aps c
is: CHEBI:58243
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
constant: false
type: Species
boundary condition: false
name: 5'-adenylyl sulfate(2-)
initial amount: NaN
is: HMDB01003
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_0cb6540a_a662_47bc_9abd_437a4f74a668
boundary condition: true
is encoded by: hsa:5832
is: SBO:0000252
name: ALDH18A1
initial concentration: NaN
type: Species
is: P54886
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_072ac9a6_bb8c_4834_a38a_5d4a5ef3e715
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
name: DLAT
is encoded by: hsa:1737
initial concentration: NaN
is: Q86YI5
boundary condition: true
type: Species

metaR PTCRTD
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
type: Reaction
name: diffusion of putriscine into the endothelial cells
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110011#
fast: false

metaM malttr e
initial amount: NaN
is: C01835
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
has only substance units: false
is: HMDB01262
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
boundary condition: false
name: maltotriose
is: CHEBI:27931

metaR HBZOPT10m
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (27235.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:15153069,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.5.1.- IT
fast: false
product: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
name: Hydroxybenzoate Decaprenyltransferase
reversible: false
kinetic law: MODEL1310110011#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.5.1.39
is: SBO:0000176

metaM itp e
is: SBO:0000247
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial concentration: 1.0
is: HMDB00189
initial amount: NaN
is: CHEBI:57614
has only substance units: false
boundary condition: false
type: Species
constant: false
name: ITP(3-)

metaM memgacpail hs r
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
is: CHEBI:15809
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_4a1f67bf_b83b_4e8a_8590_b438ac311a24
has only substance units: false
constant: false
is encoded by: hsa:1962
initial concentration: NaN
boundary condition: true
name: EHHADH
is: Q9NY65
type: Species
initial amount: NaN
is: SBO:0000252

metaM 2hb e
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:1148
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
is: HMDB00008
name: 2-Hydroxybutyrate
is: SBO:0000247

metaR r0735
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
product: MODEL1310110011#
reactant: MODEL1310110011#
modifier: MODEL1310110011#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110011#
is: SBO:0000176

metaM val L m
is: HMDB00883
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:16414
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial amount: NaN
name: L-valine
type: Species

metaM gly e
name: Glycine
boundary condition: false
notes: FORMULA: C2H5NO2 CHARGE: 0
initial concentration: 1.0
has only substance units: false
type: Species
is: C00037
is: HMDB00123
constant: false
initial amount: NaN
is: CHEBI:3339
is: SBO:0000247

metaM HC02179 e
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: 20-hydroxy-arachidonate
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: CHEBI:34306
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_d720d641_f995_4371_a6ac_504b87d87b31
boundary condition: true
name: FOLR3
type: Species
is encoded by: hsa:2352
constant: false
initial amount: NaN
is: Q05C14
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_1ae5161c_3fb1_4ef1_ae45_14f893e8f3d4
type: Species
boundary condition: true
initial amount: NaN
is: Q8TF08
is: SBO:0000252
has only substance units: false
is encoded by: hsa:170712
constant: false
initial concentration: NaN
name: COX7B2

metaR C162OHc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxy hexadecadienoyl carnitine
type: Reaction

metaR S6T1g
fast: false
product: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
modifier: MODEL1310110011#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaM orot e
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
type: Species
constant: false
is: CHEBI:30839
has only substance units: false
name: orotate
is: HMDB00226
boundary condition: false

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_0373f362_5271_4630_b0bb_010e9df7fbb1
is encoded by: hsa:2879
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: P36969
has only substance units: false
constant: false
name: GPX4
initial amount: NaN
type: Species

metaM 3thexddcoa c
notes: FORMULA: C37H58N7O18P3S CHARGE: -4
initial concentration: 1.0
is: HMDB02014
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
type: Species
name: 3-hydroxy trans7,10-hexadecadienoylcoa
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_c5101b3a_8a03_424e_b464_2c7d90243186
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:23396
is: O60331
name: PIP5K1C
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaR AMETtd
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: diffusion of S-Adenosyl-L-methionine
is described by: ECO:0000134
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110011#
type: Reaction
fast: false
product: MODEL1310110011#

metaM dgmp c
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB01044
boundary condition: false
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: CHEBI:57673
initial amount: NaN
is: C00362
initial concentration: 1.0
name: dGMP

http://identifiers.org/biomodels.db/MODEL1310110011#_f7583a69_8c7f_4d11_b774_a1e8cc82cf46
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: ACOX1
is encoded by: hsa:51
constant: false
is: B4DK61
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_b689a827_d1c6_4365_b4c7_000ad1675b3f
is encoded by: hsa:2954
boundary condition: true
is: O43708
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
constant: false
name: GSTZ1
initial amount: NaN

metaM 6a2ohxnt x
initial amount: NaN
is: CHEBI:17534
boundary condition: false
constant: false
name: 6-amino-2-oxohexanoic acid
initial concentration: 1.0
is: HMDB12151
is: SBO:0000247
type: Species
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
has only substance units: false

metaM 34dhmald m
is: C05577
type: Species
has only substance units: false
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: HMDB06242
name: 3,4-Dihydroxymandelaldehyde
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7903
boundary condition: false
initial amount: NaN
constant: false

metaR DOPAt4 2 r
fast: false
name: Dopamine reversible transport in via sodium symport (1:2)
reactant: MODEL1310110011#
product: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
kinetic law: MODEL1310110011#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110011#

metaR KCC2t
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
is described by: ECO:0000269
name: K+-Cl- cotransporter (NH4+)
is: SBO:0000185
product: MODEL1310110011#
reversible: true
modifier: MODEL1310110011#

metaM retinal c
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB01358
initial concentration: 1.0
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
initial amount: NaN
name: retinal
is: CHEBI:15035

metaM dlnlcg c
name: dihomo-gamma-linolenic acid (n-6)
is: CHEBI:53486
is: HMDB02925
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR THRGLNexR
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
reversible: true
fast: false
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110011#
name: L-threonine/glycine reversible exchange
type: Reaction
is: SBO:0000185
is described by: ECO:0000304

metaR C162OHe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C16:2OH
type: Reaction

metaM ddece1crn c
initial amount: NaN
notes: FORMULA: C19H35NO4 CHARGE: 0
initial concentration: 1.0
is: HMDB03712
type: Species
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
name: dodecenoyl carnitine

metaM orot c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
has only substance units: false
type: Species
name: Orotate
constant: false
boundary condition: false
is: CHEBI:30839
is: HMDB00226
is: C00295

metaR DOLGLCP Lter
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110011#
reversible: false
fast: false
reactant: MODEL1310110011#
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)
is described by: ECO:0000000
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110011#_ff9e0d36_98cd_4b0d_83d5_920f8bb83521
name: PANK1
is: SBO:0000252
type: Species
is encoded by: hsa:53354
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false

metaM dadp c
is: CHEBI:57667
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial amount: NaN
is: C00206
is: HMDB01508
name: dADP
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false

metaR TMNDNCCPT1
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
name: carnitine O-palmitoyltransferase
product: MODEL1310110011#
is: SBO:0000176
fast: false
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction

metaM nicrnt c
constant: false
name: Nicotinate D-ribonucleotide
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
boundary condition: false
is: CHEBI:57502
is: HMDB01132
type: Species
is: C01185
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR PI45P5P
fast: false
is: SBO:0000176
reactant: MODEL1310110011#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.36
product: MODEL1310110011#
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
type: Reaction

metaR r0400
is version of: http://identifiers.org/ec-code/1.2.4.4
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
reactant: MODEL1310110011#
reversible: true
modifier: MODEL1310110011#

metaM ttdcrn m
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
is: HMDB05066
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3413344
boundary condition: false
type: Species
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: tetradecanoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110011#_83e706ca_2b8e_4776_aab4_75addc739c63
boundary condition: true
is encoded by: hsa:80347
initial amount: NaN
name: COASY
is: Q13057
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false

metaM adpcoa x
initial amount: NaN
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C14143
name: adipoylcoa
type: Species
is: HMDB04047
has only substance units: false

metaR PDE4
is described by: ECO:0000269
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.1.4.17
fast: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
name: 3',5'-cyclic-nucleotide phosphodiesterase
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.35
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_fb3060e7_0db0_48d0_a92e_2c7c77cc2a2c
has only substance units: false
is: SBO:0000252
is: O75355
initial amount: NaN
boundary condition: true
type: Species
name: ENTPD3
constant: false
is encoded by: hsa:956
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_f9a18985_b1a6_499c_8f77_ec7cf880b95e
is encoded by: hsa:4830
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
name: NME1

http://identifiers.org/biomodels.db/MODEL1310110011#_4bdcb839_e0b9_420f_9693_bc74f0a3db6d
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is encoded by: hsa:10841
initial concentration: NaN
boundary condition: true
name: FTCD
initial amount: NaN

metaR DMATTx
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.1
is: SBO:0000176
is described by: ECO:0000134
name: dimethylallyltranstransferase
kinetic law: MODEL1310110011#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
product: MODEL1310110011#
reactant: MODEL1310110011#
modifier: MODEL1310110011#

metaR r0829
reactant: MODEL1310110011#
reversible: true
fast: false
modifier: MODEL1310110011#
is: SBO:0000185
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
product: MODEL1310110011#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/4.1.1.37
is described by: ECO:0000000

metaR TMNDNCCPT2
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
is described by: ECO:0000000
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
name: carnitine transferase
reversible: false
modifier: MODEL1310110011#

metaR r0308
type: Reaction
is: SBO:0000176
modifier: MODEL1310110011#
product: MODEL1310110011#
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
kinetic law: MODEL1310110011#
is described by: ECO:0000000
reactant: MODEL1310110011#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:

metaR ECOAH12m
is described by: ECO:0000304
modifier: MODEL1310110011#
type: Reaction
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is: SBO:0000176
kinetic law: MODEL1310110011#
fast: false

metaM lac L x
is: SBO:0000247
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
type: Species
initial concentration: 1.0
is: HMDB00190
initial amount: NaN
name: (S)-lactate
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:16651

http://identifiers.org/biomodels.db/MODEL1310110011#_fefceb5d_9e60_49f9_8b5b_98394e7b1c48
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
name: CPT1C
is encoded by: hsa:126129
boundary condition: true
is: Q8TCG5
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_2f94a071_1150_45c6_91c5_6cfc963f2b60
name: CPT1A
is: Q8WZ48
constant: false
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1374
is: SBO:0000252

metaM HC01115 c
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
name: NeuNGc
type: Species
initial amount: NaN
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
is: CHEBI:29025
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_4ecc0c02_f2e4_44b7_a992_a9df75e441f8
type: Species
name: ENPP3
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q308M7
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:5169

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaM 3hibutcoa m
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
type: Species
is: HMDB01052
name: (S)-3-Hydroxyisobutyryl-CoA
is: CHEBI:28259
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_43a5782e_5539_46ad_8b7f_48d53dff4e7c
initial concentration: NaN
is encoded by: hsa:1891
is: SBO:0000252
type: Species
is: Q13011
initial amount: NaN
name: ECH1
constant: false
boundary condition: true
has only substance units: false

metaM dc2coa m
type: Species
constant: false
is: CHEBI:61406
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
boundary condition: false
initial amount: NaN
name: trans-Dec-2-enoyl-CoA

metaM leuktrD4 c
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: HMDB03080
initial amount: NaN
has only substance units: false
boundary condition: false
name: Leukotriene D4
type: Species
is: CHEBI:28666
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM taur x
is: SBO:0000247
has only substance units: false
is: HMDB00251
name: taurine
is: CHEBI:15891
initial concentration: 1.0
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
type: Species
boundary condition: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_a3462195_a174_442a_a46f_5eb28355bd13
is encoded by: hsa:6390
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P21912
initial amount: NaN
type: Species
name: SDHB
initial concentration: NaN
constant: false

metaM udpg c
initial amount: NaN
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: HMDB00286
is: CHEBI:58367
is: C00029
initial concentration: 1.0
is: SBO:0000247
constant: false
name: UDPglucose
type: Species
boundary condition: false
has only substance units: false

metaR RE1709N
product: MODEL1310110011#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.96
is: SBO:0000176
name: RE1709
type: Reaction
modifier: MODEL1310110011#
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
fast: false

metaM pro D e
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
boundary condition: false
name: D-proline
is: CHEBI:16313
constant: false
is: HMDB03411
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR RE3628M
modifier: MODEL1310110011#
name: RE3628
fast: false
is version of: http://identifiers.org/ec-code/5.3.3.8
product: MODEL1310110011#
is: SBO:0000176
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_2b692a2a_9b53_4bd2_9086_23548e325e68
is encoded by: hsa:56606
is: Q9NRM0
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
name: SLC2A9
has only substance units: false

metaR C81CPT1
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of ocetenoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_63359a44_3f49_423b_a596_e21570a59678
has only substance units: false
constant: false
is encoded by: hsa:6240
initial amount: NaN
initial concentration: NaN
name: RRM1
type: Species
boundary condition: true
is: SBO:0000252
is: P23921

metaM glu L c
name: L-glutamate(1-)
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:29985
is: HMDB00148
type: Species

metaM itp n
name: ITP(3-)
is: HMDB00189
is: SBO:0000247
initial amount: NaN
is: CHEBI:57614
type: Species
has only substance units: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial concentration: 1.0
boundary condition: false
constant: false

metaM pyr x
type: Species
is: HMDB00243
is: SBO:0000247
boundary condition: false
name: pyruvate
has only substance units: false
constant: false
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: http://identifiers.org/pubchem.compound/3324
is: C00022
is: CHEBI:15361
initial amount: NaN
initial concentration: 1.0

metaR r0403
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
is version of: http://identifiers.org/ec-code/1.2.4.4
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
fast: false
is described by: ECO:0000000
product: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110011#_1ad4b303_2fa9_42c8_bae7_58258f889503
is encoded by: hsa:107
has only substance units: false
initial amount: NaN
boundary condition: true
name: ADCY1
type: Species
is: SBO:0000252
is: Q08828
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_5b754c73_1e5d_4978_adda_71b7d24b5b63
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5315
is: P14618
initial amount: NaN
name: PKM2
boundary condition: true
has only substance units: false
type: Species

metaR PEPCKm
kinetic law: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110011#
reversible: false
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
name: Phosphoenolpyruvate carboxykinase (GTP)
fast: false
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/4.1.1.32
type: Reaction

metaR r0517
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110011#
modifier: MODEL1310110011#
is described by: ECO:0000000
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
reversible: true
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
reactant: MODEL1310110011#
type: Reaction
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110011#_ec6caf2e_f4a6_4879_8257_e7504ba08706
boundary condition: true
constant: false
is: P05091
initial amount: NaN
initial concentration: NaN
name: ALDH2
has only substance units: false
is encoded by: hsa:217
type: Species
is: SBO:0000252

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

metaM leuktrD4 e
initial concentration: 1.0
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
has only substance units: false
boundary condition: false
type: Species
name: Leukotriene D4
is: CHEBI:28666
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB03080

metaR L LACt4r
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110011#
fast: false
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110011#
name: L-lactate reversible transport via sodium symport
product: MODEL1310110011#

metaM tethex3 e
has only substance units: false
name: tetracosahexaenoic acid, n-3
initial amount: NaN
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB02007
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_9e4ce578_4bd2_4446_95e5_6d4c980dad53
is: SBO:0000252
initial amount: NaN
constant: false
is: O95436
has only substance units: false
name: SLC34A2
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:10568

metaM docosahexcoa m
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
has only substance units: false
constant: false
is: HMDB06294
type: Species
name: 3,7,10,13,16,19-docosahexenoylcoa
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM m1mpdol L c
constant: false
has only substance units: false
type: Species
notes: FORMULA: C1360H2228N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
is: CHEBI:28067
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN

metaR C101CPT1
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decenoylcarnitine
type: Reaction

metaM pro D c
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
boundary condition: false
is: SBO:0000247
name: D-proline
has only substance units: false
is: CHEBI:16313
constant: false
type: Species
is: HMDB03411
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_2ec0ecf1_0e0a_4b2a_9562_6a02a7d6448c
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q9P2X0
type: Species
initial amount: NaN
name: DPM3
is encoded by: hsa:54344

metaM 3tetd7ecoa c
type: Species
name: 3-hydroxy tetradecenoyl-7-coa
initial concentration: 1.0
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
is: HMDB05066
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR PIter
fast: false
is described by: ECO:0000212
reversible: true
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
is: SBO:0000185
product: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
name: phosphate transport, endoplasmic reticulum
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#

metaM gdpmann c
initial amount: NaN
boundary condition: false
type: Species
name: GDP-alpha-D-mannose(2-)
is: CHEBI:57527
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
constant: false
is: HMDB01163
is: SBO:0000247

metaM 3mb2coa m
is: CHEBI:57344
is: SBO:0000247
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
initial concentration: 1.0
type: Species
is: HMDB01493
has only substance units: false
boundary condition: false
name: 3-methylbut-2-enoyl-CoA(4-)
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_45fb333c_f117_4689_b15b_5d9008e839fa
initial concentration: NaN
name: SLC6A5
type: Species
is encoded by: hsa:9152
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is: Q9Y345
has only substance units: false

metaR C181OHc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecenoylcarnitinec
type: Reaction

metaM tethex3 c
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB02007
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
type: Species
name: tetracosahexaenoic acid, n-3
boundary condition: false
initial amount: NaN
has only substance units: false

metaR r1378
product: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
is: SBO:0000176
is described by: ECO:0000000

metaR LNLNCACRNt
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110011#
type: Reaction
fast: false
name: transport into the mitochondria (carnitine)
reactant: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110011#

metaR ASCBOX
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110011#
is: SBO:0000176
is described by: ECO:0000000
fast: false
product: MODEL1310110011#
name: ascorbic acid oxidase
reactant: MODEL1310110011#

metaR TIGCRNe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tiglyl carnitine into the extra cellular fluid
type: Reaction

metaM nh4 x
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: C01342
initial amount: NaN
has only substance units: false
is: CHEBI:28938
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
name: Ammonium
is: HMDB00051

http://identifiers.org/biomodels.db/MODEL1310110011#_51f55fe4_da8e_457b_991d_6592a814d0bc
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3162
constant: false
is: Q6FH11
name: HMOX1
has only substance units: false
initial amount: NaN
type: Species

metaR LEUt5m
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reactant: MODEL1310110011#
product: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
reversible: true
name: leucine mitochondrial transport
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaM n2m2nm l
is: CHEBI:30825
type: Species
initial concentration: 1.0
is: HMDB00573
name: n2m2nmasn (w/o peptide linkage)
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C58H97N5O41 CHARGE: 0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_b1c13209_15f8_44eb_a67b_92cc07acfbe3
is: SBO:0000252
boundary condition: true
is: P11310
constant: false
is encoded by: hsa:34
initial amount: NaN
initial concentration: NaN
type: Species
name: ACADM
has only substance units: false

metaM hdcea e
initial concentration: 1.0
is: CHEBI:32372
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
name: Hexadecenoate (n-C16:1)
type: Species
constant: false
has only substance units: false
boundary condition: false
is: HMDB03229

metaM dctp n
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: SBO:0000247
is: C00458
name: dCTP
is: CHEBI:16311
type: Species
boundary condition: false
is: HMDB00998
initial concentration: 1.0

metaR CDIPTr
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.8.11
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
name: phosphatidylinositol synthase (Homo sapiens)

http://identifiers.org/biomodels.db/MODEL1310110011#_5c115b13_5d13_4d6a_8eff_b823ae16098e
boundary condition: true
is encoded by: hsa:10768
constant: false
name: AHCYL1
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: O43865
initial amount: NaN

metaR r0512
reversible: true
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110011#
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
product: MODEL1310110011#
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:

metaR CYSGLYexR
name: L-cysteine/glycine reversible exchanger
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
type: Reaction
fast: false
modifier: MODEL1310110011#
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reversible: true
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_fe4b0b2b_695f_4943_97d1_d26922fc0d04
is: SBO:0000252
type: Species
is: Q6LEN5
boundary condition: true
initial concentration: NaN
name: CHAT
is encoded by: hsa:1103
has only substance units: false
constant: false
initial amount: NaN

metaR FAOXC181C181OHm
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C18:1OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_10f2fc9e_0faa_4d36_b0f1_c8ce7068aa88
is encoded by: hsa:6476
initial concentration: NaN
name: SI
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is: P14410

metaR r0407
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.5
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
type: Reaction
is: SBO:0000176
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
product: MODEL1310110011#
modifier: MODEL1310110011#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_8317bda6_8a3c_4ddc_910b_f0b99e966c5a
constant: false
name: GUCY1B2:GUCY1A3
initial concentration: NaN
is encoded by: hsa:2982
has part: D6RDW3
initial amount: NaN
has only substance units: false
is encoded by: hsa:2974
is: SBO:0000297
type: Species
boundary condition: true

metaM hexdectecoa m
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
name: 2,4,7,10-hexadecatetraenoylcoa
type: Species
initial amount: NaN
boundary condition: false
is: HMDB02288

metaR r1377
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
product: MODEL1310110011#
fast: false
type: Reaction
reactant: MODEL1310110011#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:

metaR HPDCAt
reactant: MODEL1310110011#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: fatty acid transport via diffusion
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110011#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_0135a0d0_971d_4dcd_a0a7_8e848bb947c5
initial concentration: NaN
constant: false
is encoded by: hsa:R14373
is: SBO:0000252
name: _R14373_1_x
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_23b3c032_229b_4b40_b99e_83770e9e079e
is encoded by: hsa:230
is: P09972
has only substance units: false
name: ALDOC
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN

metaM lnlncgcoa m
name: gamma-linolenoyl-CoA(4-)
boundary condition: false
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: SBO:0000247
is: CHEBI:57363
initial concentration: 1.0
type: Species
constant: false
is: HMDB06368
initial amount: NaN

metaR r0408
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
reactant: MODEL1310110011#
modifier: MODEL1310110011#
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.4.3.5
type: Reaction
is: SBO:0000176

metaR IPDPtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
name: Isopentenyl diphosphate transport (peroxisome)
reactant: MODEL1310110011#
reversible: true
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110011#
product: MODEL1310110011#
fast: false
is: SBO:0000185

metaR GLXtp
reactant: MODEL1310110011#
reversible: true
name: glyoxylate transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
fast: false
is: SBO:0000185
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000000
type: Reaction

metaR DNDPt41m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110011#
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110011#
is described by: ECO:0000269
reactant: MODEL1310110011#
reversible: false
name: dUTP transport via dCDP antiport
kinetic law: MODEL1310110011#

metaR r1590
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110011#
is described by: ECO:0000000
product: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110011#

metaR PNTK
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110011#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.1.33
fast: false
modifier: MODEL1310110011#
name: pantothenate kinase

metaM 3thexddcoa m
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: 3-hydroxy trans7,10-hexadecadienoylcoa
initial amount: NaN
is: HMDB02014
constant: false
type: Species
notes: FORMULA: C37H58N7O18P3S CHARGE: -4
has only substance units: false

metaR r0514
modifier: MODEL1310110011#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:
kinetic law: MODEL1310110011#
name: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110011#
reactant: MODEL1310110011#

metaM glu L e
constant: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: CHEBI:29985
type: Species
is: SBO:0000247
is: HMDB00148
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: L-glutamate(1-)

http://identifiers.org/biomodels.db/MODEL1310110011#_4eacf646_6f37_4c6a_b337_95591fdc80ee
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:4967
name: OGDH
is: Q02218
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252

metaR DGK2m
name: deoxyguanylate kinase (dGMP:dATP) (mitochondrial)
reactant: MODEL1310110011#
reversible: true
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.8 Confidence Level: 2 AUTHORS: NOTES:Added EC- JLR IT
product: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#

metaR r0409
type: Reaction
is: SBO:0000176
product: MODEL1310110011#
is described by: ECO:0000000
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.2.1.10
name: UTP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
reversible: true
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275 NOTES:
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_732060a6_e979_4b4c_98e3_99ac5ebd2b8e
is: SBO:0000252
name: ALDH4A1
is: P30038
is encoded by: hsa:8659
type: Species
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_d8bbae8a_d940_4cea_885d_fc275e002d60
is: Q9NX14
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:54539
name: NDUFB11

metaR TMDPK
reversible: false
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.6.2
is: SBO:0000176
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
reactant: MODEL1310110011#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#

metaR CGLYt3 2
is described by: ECO:0000304
fast: false
name: Cys-Gly transport in via proton symport
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000185
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_8ed5b6a6_a47b_4c67_9ce2_5c0a7c64ada9
is encoded by: hsa:137872
has only substance units: false
initial amount: NaN
name: ADHFE1
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q8IWW8

metaR GLYCt
fast: false
kinetic law: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
is described by: ECO:0000000
name: glycerol transport via channel
product: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
is: SBO:0000185

metaR BHBtm
reversible: true
fast: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000000
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
type: Reaction
product: MODEL1310110011#

metaM adpac c
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
is: HMDB00448
notes: FORMULA: C6H8O4 CHARGE: -2
initial amount: NaN
name: adipic acid

metaR r1374
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
name: EC:3.2.1.14
product: MODEL1310110011#

metaM core2 g
boundary condition: false
name: Core 2
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:15876
initial concentration: 1.0
notes: FORMULA: C22H37N2O15X CHARGE: 0
initial amount: NaN
type: Species

metaM man6p c
is: HMDB01078
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
name: D-Mannose 6-phosphate
is: SBO:0000247
is: CHEBI:17369
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275

http://identifiers.org/biomodels.db/MODEL1310110011#_8b6173de_4c54_4b15_a99e_e13d5f083cb6
is encoded by: hsa:377841
name: ENTPD8
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: Q5MY95
has only substance units: false
initial concentration: NaN

metaM dtmp m
has only substance units: false
is: CHEBI:26999
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB01227
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial concentration: 1.0
name: dTMP
constant: false
boundary condition: false
is: C00364

http://identifiers.org/biomodels.db/MODEL1310110011#_87f323f3_1717_4d3e_be92_1dda3a50d8ab
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:27068
name: PPA2
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_de0b0caa_c947_4456_b3cc_733381013d2d
is encoded by: hsa:10948
is: B4DUY1
is: SBO:0000252
constant: false
name: STARD3
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_ad09c261_6fc4_4f9f_a1a5_78c35e73697a
is: SBO:0000297
has part: E9KL44
is encoded by: hsa:3032
constant: false
boundary condition: true
name: HADHA:HADHB
has only substance units: false
is encoded by: hsa:3030
type: Species
initial concentration: NaN
has part: P55084
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_2a4fa41e_9122_4334_ac1c_8ae7417311a0
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
name: CYP1A1
is: A0N0X8
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:1543

metaM 2oxoadp c
is: CHEBI:57499
is: SBO:0000247
is: HMDB00225
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
name: 2-oxoadipate(2-)
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322

metaM 3tdcrn c
name: 3-hydroxy-tetradecanoyl carnitine
is: HMDB02014
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C21H41NO5 CHARGE: 0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_239218ae_86d6_41f4_aa71_5275df5ad72c
is: F6VPY9
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:6546
name: SLC8A1
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_b1b96a94_cf6e_44ec_ac72_4fe7d9af7321
constant: false
is encoded by: hsa:93034
type: Species
is: Q96P26
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: NT5C1B
initial amount: NaN

metaM 2dodtricoa m
type: Species
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
name: 2,6,9-dodecatrienoylcoa
constant: false
has only substance units: false
is: HMDB03952
boundary condition: false
is: C05280
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaM chsterol r
name: cholesterol
is: HMDB00067
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial concentration: 1.0
is: CHEBI:16113
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
constant: false

metaM acgam1p c
name: N-Acetyl-D-glucosamine 1-phosphate
is: HMDB01367
constant: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:7125
is: SBO:0000247
type: Species
boundary condition: false

metaM hdcea c
is: SBO:0000247
is: CHEBI:32372
has only substance units: false
initial amount: NaN
name: Hexadecenoate (n-C16:1)
boundary condition: false
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
constant: false
type: Species
initial concentration: 1.0
is: HMDB03229

http://identifiers.org/biomodels.db/MODEL1310110011#_78f86149_9492_4bbb_99a3_48093e7973d7
initial concentration: NaN
constant: false
name: MDH2
is: P40926
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:4191
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_463c68d7_32f8_4594_b997_78879b115f92
constant: false
is encoded by: hsa:51
initial concentration: NaN
is: SBO:0000297
has part: B4DK61
is encoded by: hsa:1962
has part: Q9NY65
initial amount: NaN
type: Species
has only substance units: false
name: EHHADH:ACAA1:ACOX1
boundary condition: true

metaR PNTOte
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reactant: MODEL1310110011#
type: Reaction
name: Transport of (R)-Pantothenate

metaR RE1709C
reactant: MODEL1310110011#
name: RE1709
product: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:

metaM lnlncgcoa r
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
initial concentration: 1.0
is: HMDB06368
name: gamma-linolenoyl-CoA(4-)
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:57363
constant: false
boundary condition: false

metaM dlnlcg e
has only substance units: false
name: dihomo-gamma-linolenic acid (n-6)
constant: false
is: CHEBI:53486
is: HMDB02925
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
type: Species
initial amount: NaN

metaR SERtN1
product: MODEL1310110011#
fast: false
name: Serine transport (Na, H coupled)
modifier: MODEL1310110011#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
kinetic law: MODEL1310110011#
is described by: ECO:0000269
reactant: MODEL1310110011#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_918d3326_bc7d_42e4_af00_9009b64fae11
constant: false
is encoded by: hsa:2530
type: Species
name: FUT8
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: B4DFS7
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_e6111c4a_be6b_4144_a813_46a1e4c634bc
is: A1L4Q0
initial amount: NaN
is encoded by: hsa:8526
has only substance units: false
name: DGKE
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
constant: false

metaR r1375
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
is: SBO:0000185
fast: false
type: Reaction
name: Transport reaction
reversible: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000000

metaM 3tdcrn e
has only substance units: false
name: 3-hydroxy-tetradecanoyl carnitine
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C21H41NO5 CHARGE: 0
is: HMDB13336
constant: false
type: Species

metaM odecrn m
name: octadecenoyl carnitine
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: C00412
is: HMDB01114
is: CHEBI:57394
has only substance units: false

metaM dgmp e
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: SBO:0000247
is: CHEBI:57673
is: HMDB01044
type: Species
name: dGMP(2-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_c9d7ae27_aa11_4291_a1df_b9241a9b13d9
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:7360
type: Species
constant: false
name: UGP2
is: Q16851

http://identifiers.org/biomodels.db/MODEL1310110011#_41fa918a_3400_4177_a18d_528d403cfe0d
is: SBO:0000252
constant: false
is encoded by: hsa:6487
boundary condition: true
is: B4DX62
initial concentration: NaN
has only substance units: false
type: Species
name: ST3GAL3
initial amount: NaN

metaR r1585
is described by: ECO:0000000
product: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r0639
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reversible: false
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000000
reactant: MODEL1310110011#
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110011#_82696f26_5152_47de_95cb_c4d301ac0014
initial amount: NaN
is: P17516
boundary condition: true
type: Species
constant: false
is: SBO:0000252
name: AKR1C4
initial concentration: NaN
is encoded by: hsa:1109
has only substance units: false

metaM h2o r
name: H2O
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB02111
type: Species
is: C00001
is: CHEBI:15377
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_d60ad252_2923_4fc5_b106_3e34973a6cfe
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: ACP1
type: Species
is encoded by: hsa:52
initial amount: NaN
boundary condition: true
is: Q59EH3

metaM arachd e
constant: false
is: CHEBI:32395
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: arachidonate
is: SBO:0000247
is: HMDB01043
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
has only substance units: false

metaM ser L c
constant: false
has only substance units: false
is: HMDB00187
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: CHEBI:17115
initial amount: NaN
type: Species
name: L-serine
is: SBO:0000247

metaR RE3241R
fast: false
modifier: MODEL1310110011#
product: MODEL1310110011#
kinetic law: MODEL1310110011#
name: RE3241
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110011#
reversible: false

metaR TETHEX3t
type: Reaction
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
name: fatty acid transport via diffusion
reactant: MODEL1310110011#

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaR r1586
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_59b01557_2ade_4a52_94ce_5952eb5742b3
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:85365
name: ALG2
initial amount: NaN

metaM dtdp m
boundary condition: false
has only substance units: false
name: dTDP
type: Species
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C00363
constant: false

metaR EX ivcrn
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for isovaleryl carnitine
type: Reaction

metaR 5MTHFt
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
is described by: ECO:0000269
modifier: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction
is: SBO:0000185
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
kinetic law: MODEL1310110011#
reversible: true
product: MODEL1310110011#
fast: false

metaM fe3 c
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB12943
has only substance units: false
initial concentration: 1.0
notes: FORMULA: Fe CHARGE: 3
type: Species
boundary condition: false
name: Fe3+

metaR r0638
is version of: http://identifiers.org/ec-code/2.8.1.2
modifier: MODEL1310110011#
product: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
is: SBO:0000176
reversible: true
reactant: MODEL1310110011#
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_ee8c227e_0a78_4877_b980_877ddd2d3d09
initial concentration: NaN
name: FDFT1
is: P37268
is: SBO:0000252
is encoded by: hsa:2222
type: Species
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_e314b4e8_f228_43c0_af02_f1b3f41c4dac
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1351
is: Q53XN1
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: COX8A

metaR C226CRNt
name: C226 transport into the mitochondria
fast: false
is: SBO:0000185
kinetic law: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110011#
product: MODEL1310110011#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV

metaR r1583
product: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110011#
reversible: true
kinetic law: MODEL1310110011#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaM 34hpp m
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:36242
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
has only substance units: false
constant: false
name: 3-(4-hydroxyphenyl)pyruvate
type: Species
is: HMDB00707

metaR FACOAL226
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110011#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000176
name: fatty-acid--CoA ligase
reactant: MODEL1310110011#
type: Reaction

metaM lac L e
initial concentration: 1.0
constant: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
name: (S)-lactate
is: SBO:0000247
is: CHEBI:16651
is: HMDB00190
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN

metaR GCALDD
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
modifier: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
is described by: ECO:0000304
name: Glycolaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.36
reactant: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000176

metaR SMS
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.27
fast: false
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
reversible: false
modifier: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000176
name: Sphingomyelin synthase (homo sapiens)
is described by: ECO:0000269
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_1b4f9494_0d72_4a3e_a98a_605c1005eeee
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:4832
is: Q13232
initial amount: NaN
name: NME3
has only substance units: false

metaM dtdp n
type: Species
boundary condition: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: SBO:0000247
initial amount: NaN
is: HMDB01274
is: CHEBI:58369
constant: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
initial concentration: 1.0
has only substance units: false

metaR EX estradiol LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: estradiol exchange
type: Reaction

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

metaM arachd c
initial concentration: 1.0
is: CHEBI:32395
has only substance units: false
name: arachidonate
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB01043
constant: false
type: Species
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-

metaR DUMPtn
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110011#
name: dUMP nuclear transport
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
type: Reaction
kinetic law: MODEL1310110011#

metaM gacpail hs r
has only substance units: false
name: glucosaminyl-acylphosphatidylinositol
is: HMDB01401
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: C00092
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:61548
initial concentration: 1.0
is: SBO:0000247

metaM HC02213 c
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
type: Species
has only substance units: false
constant: false
name: prostaglandin-e3
initial concentration: 1.0
is: CHEBI:28031

metaM ser L e
type: Species
name: L-serine
is: HMDB00187
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
has only substance units: false
is: CHEBI:17115
boundary condition: false

metaM 2docopencoa m
boundary condition: false
is: SBO:0000247
name: 2,7,10,13,16-docosapentenoylcoa
constant: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB06294

http://identifiers.org/biomodels.db/MODEL1310110011#_1f23e439_d737_40b7_8fb4_924613b1d2c5
has only substance units: false
boundary condition: true
name: CHKB
constant: false
is: SBO:0000252
is encoded by: hsa:1120
initial concentration: NaN
initial amount: NaN
type: Species
is: Q9Y259

metaR r1584
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110011#
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM dmnoncrn c
initial amount: NaN
type: Species
notes: FORMULA: C18H37NO4 CHARGE: 0
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB06202
is: SBO:0000247
has only substance units: false
name: 4,8-dimethylnonanoyl carnitine

metaM octdececrn c
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C25H47NO4 CHARGE: 0
has only substance units: false
is: HMDB06351
initial concentration: 1.0
type: Species
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)

metaM ppi x
name: Diphosphate
has only substance units: false
is: HMDB00250
boundary condition: false
initial amount: NaN
is: C00013
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:33019
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013

metaR PPDOy
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
modifier: MODEL1310110011#
is described by: ECO:0000269
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
fast: false
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
product: MODEL1310110011#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.21
reactant: MODEL1310110011#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110011#_957e55ab_0eb3_496d_87f9_2f359c7d75b2
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6241
boundary condition: true
name: RRM2
type: Species
is: P31350

http://identifiers.org/biomodels.db/MODEL1310110011#_c1c073af_202a_430a_a9fb_7a2040229bde
has only substance units: false
name: CPT2
type: Species
initial concentration: NaN
is: P23786
is: SBO:0000252
is encoded by: hsa:1376
boundary condition: true
constant: false
initial amount: NaN

metaR C4DCe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of succinyl carnitine into the extra cellular space
type: Reaction

metaM CE2705 n
initial amount: NaN
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
is: CHEBI:15374
has only substance units: false
type: Species
name: quinonoid dihydrobiopterin
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB02281

http://identifiers.org/biomodels.db/MODEL1310110011#_2e5653da_a594_42dc_bdb6_c9fd6c0572cd
constant: false
initial concentration: NaN
name: PIGU
type: Species
is: Q9H490
initial amount: NaN
is encoded by: hsa:128869
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR SERGLYexR
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000304
modifier: MODEL1310110011#
product: MODEL1310110011#
name: L-Serine/Glycine reversible exchange
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110011#_0781db65_b77c_4732_b295_e043bb882317
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
name: CPT1B
constant: false
is: E9PCP2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1375

metaR RE1845X
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
reactant: MODEL1310110011#
is described by: ECO:0000000
product: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
name: RE1845
fast: false

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaR ALDD2x
is described by: ECO:0000000
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110011#
reversible: false
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
name: aldehyde dehydrogenase (acetaldehyde, NAD)
is version of: http://identifiers.org/ec-code/1.2.1.36
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176

metaR VACCCRNt
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: false
is: SBO:0000185
name: transport into the mitochondria (carnitine)
type: Reaction
product: MODEL1310110011#
reactant: MODEL1310110011#

metaM ksi pre13 g
constant: false
is: CHEBI:58053
type: Species
name: keratan sulfate I biosynthesis, precursor 13
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C00130
is: HMDB00175
initial concentration: 1.0
boundary condition: false

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaM csn c
is: SBO:0000247
is: HMDB00630
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
boundary condition: false
is: CHEBI:16040
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
name: cytosine
initial amount: NaN

metaM dgmp m
is: C00362
constant: false
type: Species
boundary condition: false
name: dGMP
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: SBO:0000247
is: CHEBI:57673
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB01044

metaR r1581
reactant: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110011#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110011#

metaM lac L c
initial concentration: 1.0
is: CHEBI:16651
initial amount: NaN
type: Species
name: (S)-lactate
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00190

http://identifiers.org/biomodels.db/MODEL1310110011#_7ae54502_0134_4657_8d07_201efcff0f2f
name: AHCY
type: Species
is encoded by: hsa:191
is: B3KUN3
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR FACOAL224
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
kinetic law: MODEL1310110011#
name: fatty-acid--CoA ligase
product: MODEL1310110011#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110011#
reversible: true

metaR BILIRUBt2
type: Reaction
name: bilirubin transport via bicarbonate countertransport
fast: false
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
modifier: MODEL1310110011#
product: MODEL1310110011#
reversible: true
reactant: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000269

metaR RE2999M
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110011#
product: MODEL1310110011#
name: RE2999
fast: false
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_b0205242_b67f_46f2_a291_73657ab0b861
has only substance units: false
constant: false
name: NNT
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:23530
type: Species

metaM 4ppcys c
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
is: C04352
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
type: Species
is: CHEBI:59458
is: SBO:0000247
has only substance units: false
is: HMDB01117
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false

metaM ksi pre6 g
initial amount: NaN
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 6
is: C00130
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:58053
notes: FORMULA: C107H174N7O80SX CHARGE: -2
is: SBO:0000247
constant: false
is: HMDB00175

metaR GLUTCOAACBP
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of glutaryl-CoA(5-) from mitochondria into cytosol
type: Reaction

metaM dudp c
initial concentration: 1.0
boundary condition: false
is: CHEBI:60471
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
name: dUDP
has only substance units: false
is: C01346
is: HMDB01000

metaR SGPL12r
is: SBO:0000176
type: Reaction
modifier: MODEL1310110011#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
reversible: false
reactant: MODEL1310110011#
fast: false
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/4.1.2.27
name: Sphingosine-1-phosphate lyase
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_54027c1e_1575_43d8_992c_9a3752a1ffd9
is encoded by: hsa:80025
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: PANK2
boundary condition: true
constant: false
type: Species

metaM ppi r
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
is: CHEBI:33019
initial concentration: 1.0
name: Diphosphate
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false
boundary condition: false
is: HMDB00250
is: C00013

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaR UGLCNACtg
name: UDP-GlcNAc Golgi transport via CMP antiport
reactant: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
reversible: true
product: MODEL1310110011#
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110011#_e6cadd13_b59a_4d8e_a52c_cb28ff5cab17
is encoded by: hsa:23556
name: PIGN
type: Species
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_762eccbd_e896_4748_9776_786c93dc539a
initial amount: NaN
has only substance units: false
is: O00400
name: SLC33A1
is encoded by: hsa:9197
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_bbb1bad4_6ea1_41e9_bbef_815ecffdc61a
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:586
initial concentration: NaN
name: BCAT1
initial amount: NaN
type: Species
is: P54687

metaR DHFR
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
is described by: ECO:0000254
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
name: dihydrofolate reductase
product: MODEL1310110011#
type: Reaction
reversible: true
is: SBO:0000176

metaR KSII CORE2t
type: Reaction
fast: false
reactant: MODEL1310110011#
name: keratan sulfate II (core2) transport, golgi to extracellular
kinetic law: MODEL1310110011#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110011#

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_1c8cdeda_cb31_44f3_8ece_0cf248d1ed21
is: SBO:0000252
name: _U37519_1_m
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:U37519

metaM dhap e
is: CHEBI:57642
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
name: glycerone phosphate(2-)
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
type: Species
initial amount: NaN
is: HMDB01473
initial concentration: 1.0

metaM CE5786 e
is: HMDB02710
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
name: kinetensin
boundary condition: false
type: Species
constant: false
is: CHEBI:27485

metaM h2o x
type: Species
initial concentration: 1.0
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: C00001
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
name: H2O
is: CHEBI:15377
initial amount: NaN

metaM 3hpp m
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
constant: false
has only substance units: false
type: Species
is: CHEBI:16510
is: HMDB00700
is: SBO:0000247
initial concentration: 1.0
name: 3-hydroxypropionate

http://identifiers.org/biomodels.db/MODEL1310110011#_6056304b_a999_4ab7_b72c_1d95ba784ad0
is encoded by: hsa:H77542
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
constant: false
name: _H77542_1_c
is: SBO:0000252

metaM csn e
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:16040
has only substance units: false
boundary condition: false
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
initial amount: NaN
name: cytosine
is: SBO:0000247
is: HMDB00630

metaR PI34P5K
is described by: ECO:0000000
type: Reaction
product: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
is: SBO:0000176
reversible: false
modifier: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
is version of: http://identifiers.org/ec-code/2.7.1.68

http://identifiers.org/biomodels.db/MODEL1310110011#_236658ed_3b64_4694_bc78_eeeb4b2bb03c
is encoded by: hsa:1103
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: Q6LEN6
initial amount: NaN
name: CHAT
type: Species

metaR EICOSTETt
fast: false
is described by: ECO:0000000
name: fatty acid transport via diffusion
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true

metaM bilirub e
type: Species
is: SBO:0000247
is: CHEBI:57977
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00054
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
has only substance units: false
name: bilirubin(2-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_abf1970a_c78c_47b2_a5b7_f11b35bc85b0
name: GUCY2D
is: SBO:0000252
type: Species
is encoded by: hsa:3000
is: Q02846
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false

metaM dtmp c
initial concentration: 1.0
constant: false
name: dTMP
has only substance units: false
is: HMDB01227
is: SBO:0000247
is: CHEBI:26999
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial amount: NaN
is: C00364
type: Species
boundary condition: false

metaM 3octdece1coa c
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB13336
initial concentration: 1.0
constant: false
name: 3-hydroxyoctadecenoylcoa
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_71e4c01f_124e_499e_88c4_1274dab42070
boundary condition: true
initial concentration: NaN
is: P04843
is: SBO:0000252
has only substance units: false
name: RPN1
initial amount: NaN
is encoded by: hsa:6184
constant: false
type: Species

metaM dtmp e
is: HMDB01227
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
boundary condition: false
initial amount: NaN
type: Species
constant: false
name: dTMP(2-)
is: CHEBI:26999
initial concentration: 1.0

metaR r0987
type: Reaction
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Vesicular transport

metaR EX sucr LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sucrose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_176114ed_8b59_4578_8e77_426d0bbf414f
name: _NOS2A_1_e
is encoded by: hsa:NOS2A
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true

metaR FACOAL180i
type: Reaction
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
is described by: ECO:0000269
is: SBO:0000176
name: C180 fatty acid activation
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110011#
fast: false
modifier: MODEL1310110011#
reversible: false

metaR r1580
kinetic law: MODEL1310110011#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110011#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_f189cc9d_8487_4904_ad15_c4248f2d60d5
boundary condition: true
has only substance units: false
is: P12235
constant: false
initial amount: NaN
type: Species
name: SLC25A4
is encoded by: hsa:291
is: SBO:0000252
initial concentration: NaN

metaR RE3567C
kinetic law: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
fast: false
reactant: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000176
name: RE3567
type: Reaction
reversible: true

metaR ELAIDt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
product: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110011#_60115fa9_2c14_4bea_a9fc_6c5074cf6b43
boundary condition: true
is: P27987
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
name: ITPKB
is encoded by: hsa:3707
has only substance units: false
initial concentration: NaN

metaM dhap c
is: C00111
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:57642
is: http://identifiers.org/pubchem.compound/3411
initial amount: NaN
is: HMDB01473
name: Dihydroxyacetone phosphate
type: Species
boundary condition: false
initial concentration: 1.0

metaM fe3 e
has only substance units: false
initial amount: NaN
name: Fe3+
boundary condition: false
constant: false
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
is: HMDB12943
is: CHEBI:29034
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR RE3627M
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
modifier: MODEL1310110011#
name: RE3627
is: SBO:0000176
reversible: true
product: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110011#

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_3e0d69b1_1b4e_49d5_a8f5_b981de8adbcb
initial concentration: NaN
is: Q9UPR5
initial amount: NaN
boundary condition: true
type: Species
constant: false
name: SLC8A2
has only substance units: false
is encoded by: hsa:6543
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_670ff64f_061a_4386_924e_5a27db16f0d4
is encoded by: hsa:9498
is: E7EML0
name: SLC4A8
type: Species
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_31d0d16b_7c06_4e3e_b6be_019bbb78406d
has only substance units: false
initial amount: NaN
name: COX6A1
is: P12074
is: SBO:0000252
constant: false
type: Species
boundary condition: true
is encoded by: hsa:1337
initial concentration: NaN

metaM sphgn c
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB00269
name: sphinganine(1+)
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
is: CHEBI:57817
constant: false
is: SBO:0000247
boundary condition: false

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaR r0986
name: Vesicular transport
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110011#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110011#
is described by: ECO:0000000
product: MODEL1310110011#

metaM 34hpp c
constant: false
is: CHEBI:36242
type: Species
is: SBO:0000247
initial concentration: 1.0
name: 3-(4-hydroxyphenyl)pyruvate
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
is: HMDB00707
boundary condition: false

metaR CORE2GTg
is version of: http://identifiers.org/ec-code/2.4.1.102
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110011#
fast: false
product: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000176
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus

metaM ppi n
is: CHEBI:33019
name: diphosphate(3-)
is: SBO:0000247
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false

metaR D3AIBTm
reactant: MODEL1310110011#
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110011#
kinetic law: MODEL1310110011#
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_b23a01be_451e_4375_8936_cc29cb2a2717
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q9HBH5
initial concentration: NaN
type: Species
has only substance units: false
name: RDH14
is encoded by: hsa:57665
constant: false

metaR r0630
modifier: MODEL1310110011#
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.1.3.1
type: Reaction
is: SBO:0000176
product: MODEL1310110011#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.1.3.2

metaM octdececrn m
is: HMDB06351
initial amount: NaN
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
notes: FORMULA: C25H47NO4 CHARGE: 0
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false

metaM ptdcacoa m
is: HMDB06499
has only substance units: false
type: Species
name: pentadecanoyl Coenzyme A
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM paf hs c
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
type: Species
has only substance units: false
is: CHEBI:36707
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
initial amount: NaN

metaM pail34p hs c
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
initial amount: NaN
is: CHEBI:57658
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_6a807cb7_584e_417c_877a_beaa73129c7d
type: Species
initial concentration: NaN
constant: false
is: P08195
boundary condition: true
is encoded by: hsa:6520
has only substance units: false
name: SLC3A2
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_6ff6f31a_298e_4076_b49a_4daa1e7c1232
is: SBO:0000252
is: P46721
is encoded by: hsa:6579
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
name: SLCO1A2
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_330966ac_3c48_46e6_a88b_c575aedda140
type: Species
is encoded by: hsa:11238
has only substance units: false
constant: false
initial concentration: NaN
name: CA5B
boundary condition: true
is: SBO:0000252
is: Q9Y2D0
initial amount: NaN

metaR THMPPtm
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:12014993 NOTES:IT
kinetic law: MODEL1310110011#
product: MODEL1310110011#
name: Thiamine diphosphate transport in via anion antiport, mitochondria
reactant: MODEL1310110011#

metaR CYSGLUexR
name: L-cysteine/L-glutamine reversible exchanger
kinetic law: MODEL1310110011#
is described by: ECO:0000304
is: SBO:0000185
reactant: MODEL1310110011#
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
product: MODEL1310110011#
type: Reaction
reversible: true

metaM h2o l
is: CHEBI:15377
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
name: water
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR IZPN
reactant: MODEL1310110011#
fast: false
is: SBO:0000176
name: Imidazolonepropionase
kinetic law: MODEL1310110011#
reversible: false
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction

metaM cysam c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:58029
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
type: Species
has only substance units: false
is: HMDB02991
constant: false
initial amount: NaN
name: cysteaminium

metaR FAOXC12DCC10DCx
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12DC-->C10DC)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_5a69a2a4_fa09_4f0d_ba89_eb6d364fcb79
initial amount: NaN
constant: false
name: ECHS1
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is: P30084
initial concentration: NaN
is encoded by: hsa:1892

http://identifiers.org/biomodels.db/MODEL1310110011#_9c1815c6_a068_43bd_b484_49dfa70d056a
boundary condition: true
initial concentration: NaN
name: _AI935189_1_m
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is encoded by: hsa:AI935189
initial amount: NaN

metaM bilirub r
name: bilirubin(2-)
type: Species
is: CHEBI:57977
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
boundary condition: false
constant: false
is: HMDB00054
has only substance units: false
is: SBO:0000247

metaM adpac x
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00448
notes: FORMULA: C6H8O4 CHARGE: -2
name: adipic acid
has only substance units: false
type: Species
constant: false

metaM 34hpp e
has only substance units: false
is: CHEBI:36242
is: SBO:0000247
type: Species
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
initial amount: NaN
initial concentration: 1.0
name: 3-(4-hydroxyphenyl)pyruvate
is: HMDB00707
constant: false
boundary condition: false

metaR EX hestratriol LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4,17 dihydroxy estradiol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_d483dd38_5298_4297_8708_3b510764fce4
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2746
is: E9KL48
name: GLUD1
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_76a088ec_5686_4e01_ad88_13fe923214a3
is encoded by: hsa:4830
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
name: NME1
boundary condition: true

metaM h2o m
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
name: H2O
is: C00001
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false

metaM dadp n
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: HMDB01508
boundary condition: false
is: CHEBI:57667
constant: false
name: dADP(3-)
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaM zymstnl r
name: 5alpha-cholest-8-en-3beta-ol
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:16608
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB06841
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845

http://identifiers.org/biomodels.db/MODEL1310110011#_d1c8eaf6_6fed_42aa_9f57_8b041734ee32
is encoded by: hsa:2582
initial concentration: NaN
boundary condition: true
is: Q14376
type: Species
constant: false
name: GALE
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM phe L e
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
name: L-phenylalanine
is: CHEBI:17295
has only substance units: false
boundary condition: false
is: HMDB00159
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_93fd8830_d82e_4135_adf3_e8d4f1d4a667
initial amount: NaN
is encoded by: hsa:3945
constant: false
type: Species
has part: P00338
has only substance units: false
has part: P07195
is encoded by: hsa:3939
is: SBO:0000297
boundary condition: true
initial concentration: NaN
name: LDHA:LDHB

metaM ksi pre21 g
is: C00130
is: CHEBI:58053
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00175
type: Species
initial concentration: 1.0
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 21
initial amount: NaN

metaM paf hs e
type: Species
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
is: CHEBI:36707
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: 1-alkyl 2-acteylglycerol 3-phosphocholine

http://identifiers.org/biomodels.db/MODEL1310110011#_3cbd2725_561f_4ec7_ae24_9d9feda9f75b
is encoded by: hsa:10993
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: SDS
has only substance units: false
is: P20132

metaM dadp m
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: dADP(3-)
is: HMDB01508
constant: false
is: CHEBI:57667
type: Species

metaR r0830
kinetic law: MODEL1310110011#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
type: Reaction
modifier: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.5.4.16

http://identifiers.org/biomodels.db/MODEL1310110011#_957bc5db_74af_4c45_9f9a_c335a98ab755
is: P51160
constant: false
type: Species
is encoded by: hsa:5146
initial concentration: NaN
name: PDE6C
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_af300c77_b06d_42c0_9b90_692a82cd98dc
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2878
type: Species
is: P22352
initial concentration: NaN
constant: false
initial amount: NaN
name: GPX3
has only substance units: false

metaR r1589
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
product: MODEL1310110011#
reversible: true
is described by: ECO:0000000

metaM 3octdece1coa m
is: SBO:0000247
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
name: 3-hydroxyoctadecenoylcoa
is: HMDB06294

http://identifiers.org/biomodels.db/MODEL1310110011#_60a20985_d65a_4e9c_9eff_2a97e44a2fdb
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
name: HSD17B10
is: Q99714
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3028

metaR ALDD2y
is described by: ECO:0000000
type: Reaction
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.36
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
name: aldehyde dehydrogenase (acetaldehyde, NADP)
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
is: SBO:0000176

metaM arachdcrn r
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
initial amount: NaN
is: SBO:0000247
type: Species
name: C20:4 carnitine
initial concentration: 1.0
is: CHEBI:57368
boundary condition: false
has only substance units: false
constant: false
is: HMDB06523

http://identifiers.org/biomodels.db/MODEL1310110011#_cb7f8115_e48a_4deb_9326_17db9d292c59
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:29929
is: SBO:0000252
boundary condition: true
type: Species
name: ALG6
initial amount: NaN
is: Q9Y672

metaM h2o n
is: CHEBI:15377
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB02111
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
name: water
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_f40e1181_00e9_4a40_a1fe_3156ca6d7cc3
initial amount: NaN
name: PRDX1
boundary condition: true
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5052

metaM m8mpdol L r
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:59093
notes: FORMULA: C1780H2928N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1 EHMN_ABBREVIATION: C05868
type: Species
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog

metaR FACOAL1822
type: Reaction
modifier: MODEL1310110011#
is described by: ECO:0000269
product: MODEL1310110011#
is: SBO:0000176
fast: false
reversible: true
name: fatty-acid--CoA ligase
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110011#_d7314ec8_0df2_4b12_834d_bf7d6694a083
constant: false
is: O14734
type: Species
initial concentration: NaN
name: ACOT8
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10005
has only substance units: false
boundary condition: true

metaR r2141
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
product: MODEL1310110011#
type: Reaction

metaR DLNLCGCPT2
reversible: false
reactant: MODEL1310110011#
is described by: ECO:0000000
fast: false
name: carnitine transferase
type: Reaction
kinetic law: MODEL1310110011#
product: MODEL1310110011#
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176

metaM 2decdicoa m
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
type: Species
name: 2,7-decadienoylcoa

http://identifiers.org/biomodels.db/MODEL1310110011#_f716d62f_4911_4040_bedd_5be07009de5d
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is: P78382
name: SLC35A1
is encoded by: hsa:10559
constant: false

metaR GRTTx
product: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
name: geranyltranstransferase
modifier: MODEL1310110011#
type: Reaction
is version of: http://identifiers.org/ec-code/2.5.1.1
reactant: MODEL1310110011#
is described by: ECO:0000134
kinetic law: MODEL1310110011#
is: SBO:0000176
reversible: false

metaM ahcys e
name: S-Adenosyl-L-homocysteine
is: HMDB00939
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16680
notes: FORMULA: C14H20N6O5S CHARGE: 0
type: Species
is: C00021
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_ee164c11_03a5_4baf_9785_af5711dbb2bc
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6519
boundary condition: true
initial amount: NaN
is encoded by: hsa:9056
name: SLC3A1:SLC7A7
type: Species
has part: Q9UM01
has part: Q07837
is: SBO:0000297

metaM focytC m
initial amount: NaN
constant: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:16928
name: Ferrocytochrome C

metaR r0634
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.1.4.1
type: Reaction
fast: false
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is: SBO:0000176
product: MODEL1310110011#
kinetic law: MODEL1310110011#
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: true
is described by: ECO:0000000

metaM CE2705 c
boundary condition: false
has only substance units: false
is: CHEBI:36781
is: SBO:0000247
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial amount: NaN
type: Species
initial concentration: 1.0
name: quinonoid dihydrobiopterin
constant: false

metaR GDPtg
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
type: Reaction
name: GDP intracellular transport
is: SBO:0000185
product: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000000

metaM sql r
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:15440
name: squalene
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00256

metaR C8CRNe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octanoyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_8213a329_2d6d_4b1a_8c83_13f70e98f08d
constant: false
has only substance units: false
is: SBO:0000252
is: Q96M32
name: AK7
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:122481
type: Species

metaR r2142
type: Reaction
modifier: MODEL1310110011#
fast: false
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true

metaR FACOAL1821
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110011#
fast: false
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE1514C
reversible: true
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110011#
name: fatty-acid--CoA ligase

metaR r0836
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000185

metaR DLNLCGCPT1
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
name: carnitine O-palmitoyltransferase
is: SBO:0000176
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_5e34871a_17c1_451a_b1ad_c03ff061183a
is encoded by: hsa:56606
initial concentration: NaN
constant: false
name: SLC2A9
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM biliverd c
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:57991
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
has only substance units: false
initial concentration: 1.0
is: HMDB01008
name: biliverdin(2-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_64b8d485_a738_48ef_b3a0_da2b1579af25
has only substance units: false
initial amount: NaN
is encoded by: hsa:1109
type: Species
name: AKR1C4
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is: P17516

metaR r0633
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.7.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110011#
product: MODEL1310110011#
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reversible: true

metaR r1587
kinetic law: MODEL1310110011#
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110011#
is: SBO:0000185
product: MODEL1310110011#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaM 4ppcys m
initial amount: NaN
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:59458
initial concentration: 1.0
is: HMDB01117
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
type: Species

metaM ppi m
is: CHEBI:33019
name: Diphosphate
has only substance units: false
is: C00013
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
boundary condition: false
initial amount: NaN
is: HMDB00250
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR r0835
product: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.16
is described by: ECO:0000000
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110011#
type: Reaction

metaM dudp m
is: CHEBI:60471
initial concentration: 1.0
type: Species
is: HMDB01000
boundary condition: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial amount: NaN
is: SBO:0000247
name: dUDP(3-)
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_3c702556_1990_4ebe_9a9e_fb2d45d807de
initial concentration: NaN
constant: false
is: P54750
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5136
type: Species
has only substance units: false
name: PDE1A

http://identifiers.org/biomodels.db/MODEL1310110011#_d294a8c1_7de6_40c9_8bf7_b207926df9ca
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:113
name: ADCY7
is: P51828

metaM ksi pre36 g
boundary condition: false
constant: false
is: CHEBI:28067
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 36

http://identifiers.org/biomodels.db/MODEL1310110011#_66c1d78b_2aee_48cc_875a_85a9b388c2f5
name: HMGCL
is: Q6IBC0
type: Species
is encoded by: hsa:3155
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false

metaR EX c6crn
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hexanoyl carnitine
type: Reaction

metaM ahcys c
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
initial amount: NaN
is: HMDB00939
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:16680
type: Species
has only substance units: false
boundary condition: false
is: C00021
name: S-Adenosyl-L-homocysteine

metaR r1588
is: SBO:0000185
product: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110011#
is described by: ECO:0000000

metaM dolmanp L r
type: Species
name: Dolichyl phosphate D-mannose, human liver homolog
constant: false
is: CHEBI:15809
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1

metaM HC01377 m
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: S-(3-Methylbutanoyl)-dihydrolipoamide
is: CHEBI:27462
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-10(2)9-13(16)18-8-7-11(17)5-3-4-6-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05119
initial amount: NaN

metaM dudp n
is: SBO:0000247
is: HMDB01000
name: dUDP(3-)
initial amount: NaN
constant: false
type: Species
has only substance units: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: CHEBI:60471
boundary condition: false
initial concentration: 1.0

metaR r2140
reactant: MODEL1310110011#
modifier: MODEL1310110011#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
kinetic law: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true

metaR S6T3g
product: MODEL1310110011#
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110011#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.8.2.17
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.21
is described by: ECO:0000000

metaR MTHFD2m
is described by: ECO:0000254
modifier: MODEL1310110011#
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.9
product: MODEL1310110011#
reactant: MODEL1310110011#
reversible: true
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD

metaR CYSSNAT5tc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR S6T2g
fast: false
reactant: MODEL1310110011#
is: SBO:0000176
product: MODEL1310110011#
reversible: false
modifier: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaR GLYCK2
name: glycerate kinase
reactant: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.31 Confidence Level: 2 AUTHORS: PMID:9038835 NOTES:JLR
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110011#
type: Reaction

metaR C16OHc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecanoylcarnitinec
type: Reaction

metaR GGH 5THFe
reactant: MODEL1310110011#
reversible: false
kinetic law: MODEL1310110011#
fast: false
product: MODEL1310110011#
is: SBO:0000176
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
name: Gamma-glutamyl hydrolase (5THF), extracellular

metaM arachdcrn m
constant: false
is: HMDB01322
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
initial amount: NaN
name: C20:4 carnitine
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:57387

metaM cholcoads x
initial concentration: 1.0
constant: false
is: CHEBI:27505
is: SBO:0000247
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
is: HMDB06889
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false

metaR P45027A11m
reversible: false
fast: false
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.14.13.15
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
is: SBO:0000176
kinetic law: MODEL1310110011#
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
modifier: MODEL1310110011#
is described by: ECO:0000269
reactant: MODEL1310110011#
type: Reaction

metaM ahcys r
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
name: S-adenosyl-L-homocysteine
is: SBO:0000247
notes: FORMULA: C14H20N6O5S CHARGE: 0 INCHI: InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
initial concentration: 1.0
is: HMDB00939
is: CHEBI:16680
constant: false

metaR r0990
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
kinetic law: MODEL1310110011#
fast: false
is: SBO:0000185
type: Reaction
name: Postulated transport reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110011#
reactant: MODEL1310110011#

metaR r1705
type: Reaction
product: MODEL1310110011#
name: Y+LAT2 Utilized transport
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#

metaR MTHFD2
is version of: http://identifiers.org/ec-code/3.5.4.9
name: methylenetetrahydrofolate dehydrogenase (NAD)
is described by: ECO:0000134
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
reversible: true
modifier: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#

metaR ACNAMtn
reversible: false
name: N-acetylneuraminate nuclear import
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110011#

metaR EX psylchol LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium-glycocholic acid complex
type: Reaction

metaR r0838
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.4
type: Reaction
name: Free diffusion
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110011#
fast: false
product: MODEL1310110011#
reactant: MODEL1310110011#
modifier: MODEL1310110011#
reversible: true

metaM phytcoa c
initial concentration: 1.0
is: SBO:0000247
constant: false
name: phytanoyl-CoA(4-)
boundary condition: false
has only substance units: false
is: HMDB01359
is: CHEBI:57391
type: Species
initial amount: NaN
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_2c0b2e43_9fc8_4120_9fa2_c22ba83ca2ec
name: ISYNA1
boundary condition: true
initial concentration: NaN
constant: false
is: B3KRT1
type: Species
initial amount: NaN
is encoded by: hsa:51477
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_b6bca2f5_fb6c_449f_b265_44042138679b
initial concentration: NaN
type: Species
is encoded by: hsa:HG2846-HT2983
name: _HG2846_HT2983_1_c
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_9d186d7e_2b78_49a7_b0e7_9f79ffefd514
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:412
has only substance units: false
is: SBO:0000252
boundary condition: true
name: STS
is: P08842

http://identifiers.org/biomodels.db/MODEL1310110011#_ada7c4ea_9706_4c4e_a4b7_d1bc4294d374
is: SBO:0000252
has only substance units: false
boundary condition: true
name: DGKZ
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:8525
is: G3V0F6
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_caf3f284_fa66_47a1_9762_da5b83af7951
constant: false
type: Species
is encoded by: hsa:AI345944
has only substance units: false
initial concentration: NaN
name: _AI345944_1_m
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM ptdcacoa c
is: SBO:0000247
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
name: pentadecanoyl Coenzyme A
constant: false
has only substance units: false
boundary condition: false
is: HMDB06499
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_a5d2a180_31c8_4574_90c6_c96b1974171a
is: SBO:0000252
is encoded by: hsa:43
constant: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
name: ACHE
has only substance units: false

metaR FAOXC9C7m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C9-->C7)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_66f67ef1_5f63_4786_ac2a_5ef7c10efbbd
constant: false
name: DPM3
initial concentration: NaN
is encoded by: hsa:54344
is: SBO:0000252
is: Q86TM7
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN

metaR r0410
kinetic law: MODEL1310110011#
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reversible: true
product: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000

metaM h2o e
has only substance units: false
is: CHEBI:15377
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: C00001
name: H2O
is: SBO:0000247
is: HMDB02111
boundary condition: false
constant: false

metaR r0839
is described by: ECO:0000000
modifier: MODEL1310110011#
reversible: true
name: Postulated transport reaction
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.3.1.70
kinetic law: MODEL1310110011#
fast: false
product: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:

metaM h2o c
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:3303
name: H2O
type: Species
initial concentration: 1.0
is: HMDB02111
is: C00001
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110011#_0ba9d83a_0fd8_446e_acdb_f4e4f203af73
is: SBO:0000252
is: P33316
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:1854
boundary condition: true
name: DUT

metaM hpyr c
name: 3-hydroxypyruvate
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01352
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
is: CHEBI:17180

metaR MDHm
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
name: malate dehydrogenase, mitochondrial
reversible: true
is: SBO:0000176
product: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
is described by: ECO:0000134
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.37
modifier: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_14edf3de_f9d7_46e7_ab2d_4cf460503234
constant: false
name: ENTPD1
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is: Q86VV3
has only substance units: false
initial concentration: NaN
is encoded by: hsa:953

metaM tetdec2crn c
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB02014
type: Species
is: SBO:0000247
initial amount: NaN
name: tetradecadienoyl carnitine
notes: FORMULA: C21H37NO4 CHARGE: 0

metaR ASCBt
name: L-ascorbate transport via facilitated diffusion
is: SBO:0000185
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
fast: false
reactant: MODEL1310110011#
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_c2495a6d_e5d7_4ac1_8495_196e121f08ae
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:11254
initial concentration: NaN
name: SLC6A14
is: Q9UN76
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_81336af4_8d70_4ca5_b604_4f06b810122d
initial concentration: NaN
initial amount: NaN
name: LDHD
is encoded by: hsa:197257
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q86WU2
constant: false

metaR ALACYSNaEx
is: SBO:0000185
reversible: false
is described by: ECO:0000269
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)
modifier: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
product: MODEL1310110011#

metaR XOL27OHtm
is: SBO:0000185
reactant: MODEL1310110011#
fast: false
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110011#
reversible: true
name: 27 hydroxy cholesterol transport

http://identifiers.org/biomodels.db/MODEL1310110011#_552261b9_c198_49dd_a086_82c1bdc98be5
name: DGUOK
boundary condition: true
initial concentration: NaN
has only substance units: false
is: E5KSL6
constant: false
type: Species
is encoded by: hsa:1716
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_38896e9d_7fa9_4f67_98c0_81e8234a6171
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:8560
name: DEGS1
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species

metaM cholp c
type: Species
initial concentration: 1.0
is: CHEBI:295975
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
constant: false
name: choline phosphate(1-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_88b0729e_6fda_43ed_ac60_f66d1a902977
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:219
initial amount: NaN
constant: false
name: ALDH1B1
boundary condition: true
is: P30837

metaR r1702
kinetic law: MODEL1310110011#
name: Y+LAT2 Utilized transport
reversible: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110011#
modifier: MODEL1310110011#

metaM h2o g
initial amount: NaN
is: CHEBI:15377
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
is: HMDB02111
constant: false
name: water
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_42cddcaa_7a64_4822_b051_e2ed27a7bdbc
boundary condition: true
is: SBO:0000252
is: Q16348
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
name: SLC15A2
is encoded by: hsa:6565
constant: false

metaR PTDCACRNCPT1
modifier: MODEL1310110011#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110011#
reversible: false
product: MODEL1310110011#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine fatty-acyl transferase
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ

metaM phe L c
has only substance units: false
is: HMDB00159
name: L-phenylalanine
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:17295
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079

metaM ahcys m
boundary condition: false
constant: false
name: S-Adenosyl-L-homocysteine
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:16680
initial concentration: 1.0
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: C00021
is: HMDB00939

http://identifiers.org/biomodels.db/MODEL1310110011#_e3cb95c1_5776_463b_9d44_63b31ea5a797
name: SLC1A4
constant: false
is: SBO:0000252
is: P43007
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:6509
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_1a161285_5842_41b2_aa4b_a172075d0a9a
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: NANS
initial concentration: NaN
is encoded by: hsa:54187
is: Q9NR45
has only substance units: false

metaM arachd r
constant: false
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
name: arachidonate
is: HMDB01043
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
initial concentration: 1.0
is: CHEBI:32395

metaM arg L e
boundary condition: false
type: Species
name: L-argininium(1+)
is: SBO:0000247
is: HMDB00517
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:32682
initial amount: NaN
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065

metaR r1701
is: SBO:0000185
product: MODEL1310110011#
fast: false
type: Reaction
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: false

metaM ppi c
initial concentration: 1.0
initial amount: NaN
is: HMDB00250
is: C00013
name: Diphosphate
is: SBO:0000247
is: CHEBI:0
constant: false
notes: FORMULA: HO7P2 CHARGE: -3
type: Species
boundary condition: false
has only substance units: false

metaM tetdec2crn e
name: tetradecadienoyl carnitine
notes: FORMULA: C21H37NO4 CHARGE: 0
type: Species
constant: false
is: HMDB05066
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaM tdcrn c
is: HMDB05066
constant: false
boundary condition: false
name: myristoyl carnitine
has only substance units: false
is: SBO:0000247
notes: FORMULA: C21H41NO4 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
type: Species

metaM Rtotal e
constant: false
is: C00255
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: CO2FULLR CHARGE: -1
is: SBO:0000247
name: R total
type: Species
is: CHEBI:3554
initial amount: NaN
is: HMDB00244

metaM zymst r
is: SBO:0000247
is: CHEBI:18252
initial amount: NaN
boundary condition: false
is: HMDB06271
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
has only substance units: false
type: Species
initial concentration: 1.0
name: zymosterol
constant: false

metaR FACOAL245 2
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
type: Reaction
is: SBO:0000176
reversible: true
product: MODEL1310110011#
is described by: ECO:0000269
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaM ksi pre16 g
initial concentration: 1.0
is: HMDB00175
boundary condition: false
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
has only substance units: false
is: SBO:0000247
type: Species
constant: false
is: C00130
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 16
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110011#_9032f6bf_95ef_4107_b4f7_a19a8077bf7d
constant: false
name: ALG8
is encoded by: hsa:79053
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR CRNrtx
name: reversible transport of L-Carnitine in peroxisome
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
kinetic law: MODEL1310110011#
product: MODEL1310110011#
fast: false
reactant: MODEL1310110011#

metaM arg L c
name: L-argininium(1+)
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00517
constant: false
is: CHEBI:32682
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
boundary condition: false

metaM cdpdag hs c
constant: false
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
name: CDP-diacylglycerol(2-)
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
is: CHEBI:58332
initial concentration: 1.0

metaM 2dr1p c
is: CHEBI:58576
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
name: 2-Deoxy-D-ribose 1-phosphate
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB01351
is: C00672
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR FACOAL245 1
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110011#
name: fatty-acid--CoA ligase
modifier: MODEL1310110011#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#
is: SBO:0000176
reversible: true

metaM ppi e
type: Species
initial concentration: 1.0
boundary condition: false
is: C00013
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: CHEBI:33019
name: Diphosphate
is: HMDB00250
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_c3361189_4e3d_4f98_b574_d334d18df9a1
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: PLCD1
initial amount: NaN
has only substance units: false
is: P51178
is encoded by: hsa:5333

metaR EX dchac LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for deoxycholic acid
type: Reaction

metaM tdcrn e
is: HMDB05066
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: myristoyl carnitine
notes: FORMULA: C21H41NO4 CHARGE: 0
has only substance units: false
type: Species
initial concentration: 1.0

metaM xol7ah2al c
initial amount: NaN
has only substance units: false
type: Species
is: HMDB06894
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: CHEBI:27428
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_53859fd6_e2f1_483a_aa0e_e433ff112c33
boundary condition: true
type: Species
is encoded by: hsa:AD000092
has only substance units: false
name: _AD000092_1_c
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN

metaR ACNAM9PL
type: Reaction
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD
is: SBO:0000176
fast: false
is described by: ECO:0000269
reversible: false
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
reactant: MODEL1310110011#
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.5.1.56
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_1a2edffd_7066_4064_981d_a107b629c337
boundary condition: true
is encoded by: hsa:1633
is: P27707
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
name: DCK

metaM Sfglutth c
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:57688
is: HMDB01550
is: SBO:0000247
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
name: S-formylglutathionate(1-)
has only substance units: false

metaM sucsal m
type: Species
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
initial concentration: 1.0
has only substance units: false
is: CHEBI:57706
name: Succinic semialdehyde
is: HMDB01259
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaM 2mop c
initial concentration: 1.0
type: Species
name: 2-methyl-3-oxopropanoate
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
constant: false
is: CHEBI:57700
is: SBO:0000247
is: HMDB01172

http://identifiers.org/biomodels.db/MODEL1310110011#_71b2d15d_51fa_4705_bf10_c0b02fb8db51
initial amount: NaN
boundary condition: true
is: P08319
is: SBO:0000252
is encoded by: hsa:127
initial concentration: NaN
constant: false
type: Species
has only substance units: false
name: ADH4

metaM Rtotal c
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: R total
is: HMDB00904
notes: FORMULA: CO2FULLR CHARGE: -1
is: SBO:0000247
is: CHEBI:16349
constant: false

metaR r1921
reactant: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110011#
fast: false
name: Y+LAT2 Utilized transport
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110011#
reversible: false

metaM bilirub c
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57977
name: bilirubin(2-)
has only substance units: false
is: HMDB00054
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_b141b508_3c1e_4db0_868f_210ca93ed26d
name: SLC22A5
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: O76082
initial concentration: NaN
is encoded by: hsa:6584
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_0b018383_484c_4db7_a2b0_8fa80b37a96d
is encoded by: hsa:4258
initial amount: NaN
constant: false
name: MGST2
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is: D6RBB5
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_4ce9fab0_c908_4724_8822_bf6c5a860a40
is: Q96C36
is encoded by: hsa:29920
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
name: PYCR2
is: SBO:0000252
type: Species

metaR G13MT L
is version of: http://identifiers.org/ec-code/2.4.1.132
product: MODEL1310110011#
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110011#
modifier: MODEL1310110011#
name: Glycolipid 1,3-alpha-D-mannosyltransferase (liver)
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_1635cda9_8721_4ca0_8c21_618472c80d31
is: SBO:0000252
is: B2RD24
type: Species
boundary condition: true
is encoded by: hsa:25902
name: MTHFD1L
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_15b7a590_7aae_4d20_9732_2862c3422627
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:257068
is: Q0VAA5
initial concentration: NaN
name: PLCXD2
constant: false

metaR GLYSNAT5tc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

metaR r1700
is: SBO:0000185
fast: false
modifier: MODEL1310110011#
reversible: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_b95a891b_b4fa_41d3_a189_f371876ee1e6
name: _AV717590_1_c
constant: false
is encoded by: hsa:AV717590
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaR r0523
fast: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
modifier: MODEL1310110011#
type: Reaction
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110011#
is described by: ECO:0000000
reactant: MODEL1310110011#
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.17.4.1
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2

metaR AG13T1g
product: MODEL1310110011#
reactant: MODEL1310110011#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
is described by: ECO:0000000
modifier: MODEL1310110011#

metaM HC00229 e
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
is: SBO:0000247
has only substance units: false
name: Isomaltose
initial concentration: 1.0
type: Species
is: CHEBI:28189
initial amount: NaN
constant: false

metaM 4izp c
is: HMDB01014
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
constant: false
initial amount: NaN
is: CHEBI:57255
type: Species
has only substance units: false
name: 4-Imidazolone-5-propanoate
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_2f7de0bd_79ba_4615_91a5_3ca68c4ff451
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: P42765
is encoded by: hsa:10449
constant: false
name: ACAA2

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_73c36490_0ed0_48d8_8864_30d2d3e5a86c
is: Q16822
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5106
type: Species
name: PCK2

metaR UGT1A2r
fast: false
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
reversible: false
notes: GENE_ASSOCIATION: (54575.1) or (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 4 AUTHORS: PMID:15117964,PMID:9295054 NOTES:NJ
reactant: MODEL1310110011#
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.17
product: MODEL1310110011#
is: SBO:0000176

metaM 2octpencoa m
is: HMDB06294
name: 2,6,9,12,15-octadecapentenoylcoa
initial concentration: 1.0
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false

metaR EX glyb LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycine betaine exchange
type: Reaction

metaM arachd l
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
boundary condition: false
name: arachidonate
has only substance units: false
initial concentration: 1.0
is: HMDB01043
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:32395
type: Species

metaM clpnd c
is: HMDB06528
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial amount: NaN
name: clupanodonic acid
constant: false
type: Species
is: SBO:0000247
is: CHEBI:53488
boundary condition: false

metaM c6crn c
is: HMDB00705
type: Species
is: SBO:0000247
name: hexanoyl carnitine
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C13H25NO4 CHARGE: 0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_a3c2c471_d8b1_43b9_9c87_20263461a0ba
has only substance units: false
initial concentration: NaN
is: Q9ULC5
name: ACSL5
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:51703
is: SBO:0000252
type: Species

metaR GACPAILter
name: glucosaminyl-acylphosphatidylinositol ER flippase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
reactant: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
kinetic law: MODEL1310110011#
fast: false
reversible: false
type: Reaction

metaR PHCDm
is: SBO:0000176
is described by: ECO:0000304
fast: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
product: MODEL1310110011#
reversible: false
is version of: http://identifiers.org/ec-code/1.5.1.12
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
type: Reaction
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase

metaM HC02023 r
is: SBO:0000247
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
name: Cholesterol-ester-ol
initial amount: NaN
is: CHEBI:46898
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_405918b9_6bfa_4bf6_811b_6214497a6c65
constant: false
name: _728226_1_m
initial concentration: NaN
is encoded by: hsa:728226
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM adpcoa c
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
boundary condition: false
name: adipoylcoa
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: HMDB04047
is: SBO:0000247
initial concentration: 1.0
is: C14143

http://identifiers.org/biomodels.db/MODEL1310110011#_79dbaa35_7d36_4c74_9864_161672112d1e
boundary condition: true
is: B7Z9T9
initial amount: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:5158
initial concentration: NaN
is: SBO:0000252
name: PDE6B

http://identifiers.org/biomodels.db/MODEL1310110011#_5f67d8a7_6565_45d8_8588_65e615548caf
initial concentration: NaN
is encoded by: hsa:1582
initial amount: NaN
constant: false
is: Q9UNU6
is: SBO:0000252
type: Species
has only substance units: false
name: CYP8B1
boundary condition: true

metaM dhbpt c
initial amount: NaN
boundary condition: false
name: 6,7-dihydrobiopterin
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
constant: false
type: Species
initial concentration: 1.0
is: HMDB00038
is: CHEBI:20680

metaM noncoa m
type: Species
is: HMDB13028
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: nonanoylcoa
notes: FORMULA: C30H48N7O17P3S CHARGE: -4
is: C01942

http://identifiers.org/biomodels.db/MODEL1310110011#_93b79877_c826_456a_840f_ec7b48308065
name: ATP2B2
has only substance units: false
type: Species
is: Q4J699
constant: false
boundary condition: true
is encoded by: hsa:491
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaM dolmanp L c
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: SBO:0000247
name: Dolichyl phosphate D-mannose, human liver homolog
is: CHEBI:15809

metaR r0522
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
kinetic law: MODEL1310110011#
reversible: false
type: Reaction
reactant: MODEL1310110011#
is: SBO:0000176
modifier: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:

metaR RE1254C
reversible: true
is: SBO:0000176
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
type: Reaction
fast: false
name: RE1254
is described by: ECO:0000000

metaR C141CPT1
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecenoylcarnitine
type: Reaction

metaR r2404
modifier: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
is: SBO:0000185
kinetic law: MODEL1310110011#
reversible: false
product: MODEL1310110011#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaR ACOAD1fm
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
kinetic law: MODEL1310110011#
fast: false
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
reactant: MODEL1310110011#
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
product: MODEL1310110011#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM dttp c
constant: false
is: HMDB01342
is: C00459
has only substance units: false
name: dTTP
is: CHEBI:37568
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459

http://identifiers.org/biomodels.db/MODEL1310110011#_c505e309_3319_4caf_8256_d40cdee278a1
initial concentration: NaN
name: CA6
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is: Q5FC00
has only substance units: false
is encoded by: hsa:765

http://identifiers.org/biomodels.db/MODEL1310110011#_0e5bafe1_7529_4174_a241_adcaecd03177
initial amount: NaN
boundary condition: true
is encoded by: hsa:3295
type: Species
is: E9PB82
name: HSD17B4
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR ACALDtm
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110011#
product: MODEL1310110011#
name: acetaldehyde mitochondrial diffusion
fast: false
reactant: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000185

metaM CE4792 m
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
boundary condition: false
is: CHEBI:12947
name: 3-oxo-cis-8-tetradecenoyl-CoA
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_4e5e19b2_bf2d_479b_854d_64e2be2101d9
is: SBO:0000252
is encoded by: hsa:8776
name: MTMR1
initial amount: NaN
constant: false
initial concentration: NaN
is: Q13613
boundary condition: true
type: Species
has only substance units: false

metaR GMPtg
is described by: ECO:0000269
name: GMP transport (Golgi)
fast: false
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction

metaR FAOXC8DCC6DCx
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8DC-->C6DC)x
type: Reaction

metaM arg L m
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: HMDB00517
type: Species
boundary condition: false
has only substance units: false
name: L-argininium(1+)
constant: false
initial amount: NaN
is: CHEBI:32682

metaM arachcoa m
is: SBO:0000247
is: CHEBI:15527
boundary condition: false
is: HMDB04258
name: arachidyl coenzyme A
has only substance units: false
initial amount: NaN
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
constant: false
initial concentration: 1.0
type: Species

metaR GTHRDtr
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110011#
name: glutathione transport via diffusion
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - NJ
reversible: true
kinetic law: MODEL1310110011#
type: Reaction

metaM c6crn e
notes: FORMULA: C13H25NO4 CHARGE: 0
has only substance units: false
initial concentration: 1.0
name: hexanoyl carnitine
is: SBO:0000247
type: Species
constant: false
is: HMDB00705
initial amount: NaN
boundary condition: false

metaR r1924
reversible: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110011#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000000

metaR FAOXC102C81m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

metaR OCT11EFATP
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of vaccenic acid by cells
type: Reaction

metaR ALDD2xm
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110011#
modifier: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
is: SBO:0000176
is described by: ECO:0000134
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD

metaM arachdcrn c
type: Species
is: CHEBI:57387
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
constant: false
is: HMDB01322
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
name: C20:4 carnitine
is: SBO:0000247

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaR XYLTD Dr
product: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction
name: xylitol dehydrogenase (D-xyulose-forming)
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110011#

metaR r2402
is described by: ECO:0000000
kinetic law: MODEL1310110011#
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110011#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

metaM ksi pre1 g
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 1
is: HMDB00175
notes: FORMULA: C79H129N5O57X CHARGE: -1
is: C00130
is: CHEBI:58053
is: SBO:0000247

metaM dttp e
name: dTTP(4-)
initial amount: NaN
is: CHEBI:37568
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
constant: false
is: HMDB01342

metaR FAOXC184m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_1f99280d_1d6b_43bd_a9ac_7d2e6ef984d2
initial concentration: NaN
is: O15357
boundary condition: true
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:3636
name: INPPL1

http://identifiers.org/biomodels.db/MODEL1310110011#_486fb2b4_932d_45b7_bc91_a5a39a154e6e
is: O43292
initial concentration: NaN
has only substance units: false
name: GPAA1
type: Species
is encoded by: hsa:8733
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_a68b1a88_d9db_4902_8927_763e48e47fbe
name: _N63787_1_c
is: SBO:0000252
boundary condition: true
is encoded by: hsa:N63787
initial concentration: NaN
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaR MI13PP
reactant: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
reversible: false
product: MODEL1310110011#
type: Reaction
name: inositol-1,3-bisphosphate 3-phosphatase
kinetic law: MODEL1310110011#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110011#_bd4a62b1_08aa_4832_a894_526565665443
constant: false
has only substance units: false
name: RPE
is: SBO:0000252
initial concentration: NaN
is: Q53TV9
initial amount: NaN
is encoded by: hsa:6120
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_a8c93c15_e419_41d1_a9ed_dd7ad76e33b2
has only substance units: false
name: NDUFA12
initial amount: NaN
is: F8VQS7
constant: false
boundary condition: true
is encoded by: hsa:55967
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_d942e270_2160_4784_8b2f_9ec8dde9c583
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: COX7A2L
is encoded by: hsa:9167
is: Q6FGA0
constant: false
type: Species
boundary condition: true
has only substance units: false

metaR RE2814R
name: RE2814
product: MODEL1310110011#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
reversible: true
fast: false
type: Reaction

metaM dump c
name: dUMP
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: C00365
is: HMDB01409
is: CHEBI:246422
initial concentration: 1.0
constant: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365

metaR CTPtn
is described by: ECO:0000000
product: MODEL1310110011#
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
name: CTP diffusion in nucleus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
fast: false
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_e698afbe_a0d1_45c3_bd52_10b2e8446478
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
name: ECHS1
is: P30084
initial amount: NaN
constant: false
is encoded by: hsa:1892
initial concentration: NaN

metaR BAAT4x
is: SBO:0000176
kinetic law: MODEL1310110011#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false
name: bile acid Coenzyme A: amino acid N-acyltransferase
product: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:fourth version analog added in similarity to BAAT1x, BAAT2x NJ
modifier: MODEL1310110011#
reversible: false
type: Reaction

metaR PRGSTRNt
product: MODEL1310110011#
type: Reaction
name: Progesterone transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000185
fast: false
reversible: true

metaM dttp n
initial amount: NaN
is: CHEBI:37568
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: C00459
type: Species
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: HMDB01342
name: dTTP

metaM spc hs c
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
name: sphingosylphosphorylcholine
is: http://identifiers.org/pubchem.compound/5311445

metaR r0604
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
modifier: MODEL1310110011#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110011#
is: SBO:0000176
product: MODEL1310110011#
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_93dcd99a_a9ac_418b_bd50_15134bdecfef
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
name: PLCZ1
is encoded by: hsa:89869
is: SBO:0000252
is: Q86YW0
type: Species
has only substance units: false

metaR GLNSERNaEx
kinetic law: MODEL1310110011#
name: L-serine/L-glutamine Na-dependent exchange (Gln-L in)
reversible: false
product: MODEL1310110011#
is: SBO:0000185
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110011#
fast: false
is described by: ECO:0000269
type: Reaction

metaR FAOXC2031836m
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:3 -> c18:3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
kinetic law: MODEL1310110011#
is: SBO:0000176
reactant: MODEL1310110011#
name: Beta oxidation of fatty acid
modifier: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_ed0cf8cb_48c3_47d2_8246_71f76fb332da
has only substance units: false
is encoded by: hsa:3098
initial amount: NaN
boundary condition: true
is: B3KXY9
constant: false
is: SBO:0000252
type: Species
name: HK1
initial concentration: NaN

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

metaR XOLDIOLONEt
product: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#

metaR r0752
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
kinetic law: MODEL1310110011#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110011#
modifier: MODEL1310110011#
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5

metaM dd2coa m
name: trans-dodec-2-enoyl-CoA(4-)
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:57330
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
initial amount: NaN
is: HMDB03712
is: SBO:0000247

metaM m6mpdol L r
boundary condition: false
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
notes: FORMULA: C1660H2728N20O520P20 CHARGE: -20
type: Species
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:37635
initial amount: NaN
initial concentration: 1.0

metaR FAOXC164GC163m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

metaR RE1521M
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
reversible: true
name: RE1521
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110011#
is: SBO:0000176
is described by: ECO:0000000

metaM trdrd m
name: Reduced thioredoxin
boundary condition: false
initial amount: NaN
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
is: CHEBI:15967
has only substance units: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR 34HPPOR
reversible: false
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
is described by: ECO:0000269
fast: false
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110011#
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.27

metaR r0841
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.1.271
reactant: MODEL1310110011#
reversible: true
type: Reaction
name: Free diffusion
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000185

metaM na1 r
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:29101
has only substance units: false
is: HMDB00588
name: sodium(1+)
initial concentration: 1.0

metaR r0954
is described by: ECO:0000000
kinetic law: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17180682 NOTES:
name: MCT 1 Transport reaction
is: SBO:0000185
reactant: MODEL1310110011#
product: MODEL1310110011#
reversible: true
type: Reaction

metaR EX c4dc
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for succinyl carnitine
type: Reaction

metaM spc hs e
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
name: sphingosylphosphorylcholine
initial amount: NaN
type: Species
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5311445

metaM trdox c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:18191
type: Species
name: Oxidized thioredoxin
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
is: C00343

metaM fru e
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: HMDB00660
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
name: D-Fructose
constant: false
is: C00095
is: CHEBI:15824

metaM mi1345p c
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
constant: false
initial amount: NaN
type: Species
is: CHEBI:57895
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB01059
is: SBO:0000247

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaR FACOAL181i
modifier: MODEL1310110011#
name: C181 fatty acid activation
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
is described by: ECO:0000269

metaM dhlam m
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:17694
name: dihydrolipoamide
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00985

metaR r0840
reversible: true
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.70
name: Free diffusion
is: SBO:0000185
product: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110011#
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_43b7ab2c_98a1_439a_8b72_3899027c2fa4
initial amount: NaN
is: Q9BWD1
has only substance units: false
is encoded by: hsa:39
initial concentration: NaN
name: ACAT2
boundary condition: true
constant: false
type: Species
is: SBO:0000252

metaM dttp m
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: C00459
is: HMDB01342
is: SBO:0000247
has only substance units: false
name: dTTP
constant: false
is: CHEBI:37568
type: Species
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459

metaR R group phosphotase 1
is described by: ECO:0000000
kinetic law: MODEL1310110011#
is: SBO:0000176
name: R group phosphotase 1
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110011#
product: MODEL1310110011#

metaR C161CPT1
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
is: SBO:0000176
product: MODEL1310110011#
fast: false
name: production of palmitoleoylcarnitine
kinetic law: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:TDV
reactant: MODEL1310110011#
modifier: MODEL1310110011#

metaR r0754
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
reactant: MODEL1310110011#
reversible: true
fast: false
kinetic law: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
is described by: ECO:0000000

metaM 4pyrdx e
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00017
notes: FORMULA: C8H9NO4 CHARGE: 0 INCHI: InChI=1S/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)/p-1 EHMN_ABBREVIATION: C00847
is: CHEBI:30959
name: 4-pyridoxate
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species

metaM tetpent6coa c
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: tetracosapentaenoyl coenzyme A, n-6
type: Species
is: C16172
constant: false

metaR FACOAL1832
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
fast: false
modifier: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE3114C
kinetic law: MODEL1310110011#
reversible: true
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase

metaM asn L e
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00168
name: L-asparagine
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
constant: false
type: Species
is: CHEBI:17196
boundary condition: false

metaM prostge1 c
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: prostaglandin E1(1-)
is: CHEBI:57397
is: HMDB01442
type: Species
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
boundary condition: false

metaM xol7aone m
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
name: 7alpha-hydroxycholest-4-en-3-one
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:17899
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: HMDB01993

metaM mthgxl c
type: Species
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
is: HMDB01167
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:17158
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: methylglyoxal

metaM 3hdeccoa m
is: SBO:0000247
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: HMDB02288
initial amount: NaN
name: 3-hydroxyhexadecenoylcoa

metaM fru c
is: CHEBI:15824
is: HMDB00660
name: D-Fructose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: C00095

metaR C161CPT2
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
is: SBO:0000176
reactant: MODEL1310110011#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110011#
product: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
name: transport of Hexadecenoyl-CoA into mitochondrial matrix

http://identifiers.org/biomodels.db/MODEL1310110011#_0bdef226_6c60_498b_b82b_eb3836ab5c94
boundary condition: true
is encoded by: hsa:4698
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q16718
has only substance units: false
name: NDUFA5

metaR r0753
kinetic law: MODEL1310110011#
is described by: ECO:0000000
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is: SBO:0000176
product: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110011#
modifier: MODEL1310110011#
fast: false

metaR FAOXC16C16OHm
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C16OH)m
type: Reaction

metaR FACOAL1831
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110011#
is: SBO:0000176
kinetic law: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
product: MODEL1310110011#
name: fatty-acid--CoA ligase
is described by: ECO:0000269
fast: false

metaR C12OHc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdodecanoylcarnitinec
type: Reaction

metaR r0603
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
fast: false
kinetic law: MODEL1310110011#
reversible: true
type: Reaction
modifier: MODEL1310110011#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.12
product: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
is: SBO:0000176

metaR r2408
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is: SBO:0000185
reactant: MODEL1310110011#
reversible: false
product: MODEL1310110011#
modifier: MODEL1310110011#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110011#

metaR P450SCC1m
is described by: ECO:0000134
type: Reaction
name: cholesterol monooxygenase
kinetic law: MODEL1310110011#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
product: MODEL1310110011#
is: SBO:0000176
reactant: MODEL1310110011#

metaR CRNCARtp
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110011#
product: MODEL1310110011#
fast: false
name: carnitine-acetylcarnitine carrier, peroxisomal
is: SBO:0000185
type: Reaction

metaR EX glyphe LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylphenylalaine
type: Reaction

metaM 4pyrdx c
initial concentration: 1.0
notes: FORMULA: C8H9NO4 CHARGE: 0 INCHI: InChI=1S/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)/p-1 EHMN_ABBREVIATION: C00847
is: SBO:0000247
constant: false
is: HMDB00017
has only substance units: false
name: 4-pyridoxate
boundary condition: false
is: CHEBI:30959
initial amount: NaN
type: Species

metaR It
fast: false
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
is: SBO:0000185
product: MODEL1310110011#
name: Iodide uniport
reactant: MODEL1310110011#
type: Reaction
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110011#

metaM asn L c
is: CHEBI:17196
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
type: Species
name: L-asparagine
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: SBO:0000247
is: HMDB00168

metaM eicostetcoa m
is: C16164
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
constant: false
name: eicosatetranoyl coenzyme A

metaM dcacoa m
name: Decanoyl-CoA (n-C10:0CoA)
is: CHEBI:61430
constant: false
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: C05274
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: SBO:0000247
is: HMDB06404
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_a60550db_7be7_4893_900f_bc5a16cc2214
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q6ZWP6
type: Species
is encoded by: hsa:27034
name: ACAD8
is: SBO:0000252
has only substance units: false

metaR r0755
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
modifier: MODEL1310110011#
reversible: true
reactant: MODEL1310110011#
is: SBO:0000176
fast: false
product: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
kinetic law: MODEL1310110011#
is described by: ECO:0000000

metaM f1p c
is: SBO:0000247
initial amount: NaN
is: CHEBI:18105
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00662 EHMN_ABBREVIATION: C01094
has only substance units: false
is: C01094
is: HMDB01076
constant: false
boundary condition: false
name: D-Fructose 1-phosphate
initial concentration: 1.0

metaM glyc R m
type: Species
is: SBO:0000247
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
initial amount: NaN
name: D-glycerate
has only substance units: false
is: CHEBI:16659
boundary condition: false
is: HMDB00139
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_8d114afb_f2ea_44ef_ab08_0622bd2a8590
constant: false
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: HAO2
is encoded by: hsa:51179
is: SBO:0000252

metaR EX psyl LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium
type: Reaction

metaR r0541
type: Reaction
reactant: MODEL1310110011#
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
product: MODEL1310110011#
reversible: true
is: SBO:0000176
modifier: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:

metaR EX lgnc LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lignoceric acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_daf88161_a8c8_4d97_8754_2c46ffaa947e
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P41222
has only substance units: false
is encoded by: hsa:5730
type: Species
name: PTGDS

http://identifiers.org/biomodels.db/MODEL1310110011#_ec42b1d3_cf87_4ea3_a3f5_d4dfcc5d41a9
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:160287
type: Species
name: LDHAL6A
constant: false
is: Q6ZMR3

metaR r0330
fast: false
is: SBO:0000176
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
is described by: ECO:0000000
product: MODEL1310110011#
modifier: MODEL1310110011#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#

metaM trdrd c
is: CHEBI:15967
boundary condition: false
initial concentration: 1.0
is: C00342
name: Reduced thioredoxin
is: SBO:0000247
constant: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
type: Species
initial amount: NaN
has only substance units: false

metaM xol7aone r
boundary condition: false
is: SBO:0000247
has only substance units: false
name: 7alpha-hydroxycholest-4-en-3-one
constant: false
is: HMDB01993
initial concentration: 1.0
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
initial amount: NaN
is: CHEBI:17899
type: Species

metaM g1p c
is: CHEBI:58601
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB01586
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
initial concentration: 1.0
constant: false
name: D-Glucose 1-phosphate
is: C00103
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_7df01bc7_4045_4563_8a4a_90adc94fb350
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is: E9KL44
name: HADHA
is encoded by: hsa:3030
type: Species
initial amount: NaN
has only substance units: false

metaR RE3242R
reactant: MODEL1310110011#
is: SBO:0000176
modifier: MODEL1310110011#
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
name: RE3242

metaR r0758
is: SBO:0000176
name: 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase Tryptophan metabolism EC:1.2.1.3
is version of: http://identifiers.org/ec-code/3.5.4.16
product: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:8155713,PMID:8605195 NOTES:
modifier: MODEL1310110011#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110011#
reversible: true

metaM ser D e
is: CHEBI:16523
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB03406
name: D-serine
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_ab930912_1ae0_4c79_a55e_df777be0d7ef
has only substance units: false
name: KL
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9365
boundary condition: true
is: SBO:0000252
type: Species
is: Q9UEF7

http://identifiers.org/biomodels.db/MODEL1310110011#_06cd6316_c4c2_48dd_b670_6e45b0fc23d4
type: Species
boundary condition: true
constant: false
name: HSD3B7
is encoded by: hsa:80270
initial amount: NaN
has only substance units: false
is: Q9H2F3
is: SBO:0000252
initial concentration: NaN

metaM tsul m
type: Species
is: HMDB00257
initial concentration: 1.0
name: thiosulfate(2-)
is: CHEBI:16094
initial amount: NaN
has only substance units: false
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
constant: false
boundary condition: false
is: SBO:0000247

metaM sphings c
type: Species
is: CHEBI:57756
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00252
constant: false
name: sphingosine(1+)
initial amount: NaN
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319

http://identifiers.org/biomodels.db/MODEL1310110011#_283e8899_a6a8_4327_a01d_0b06ed3239be
type: Species
initial concentration: NaN
is encoded by: hsa:3283
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: HSD3B1
is: P14060

metaM ser D c
type: Species
is: SBO:0000247
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: HMDB03406
constant: false
has only substance units: false
initial amount: NaN
name: D-serine
initial concentration: 1.0
is: CHEBI:16523
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_af446637_3011_47b9_add3_d15d3e5dc3ab
type: Species
initial concentration: NaN
name: PRDX3
is: P30048
boundary condition: true
is encoded by: hsa:10935
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false

metaM glyc R c
constant: false
name: D-glycerate
type: Species
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
has only substance units: false
is: SBO:0000247
is: HMDB00139
is: CHEBI:16659
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR BAMPPALDOX
type: Reaction
modifier: MODEL1310110011#
reversible: false
fast: false
reactant: MODEL1310110011#
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/1.2.1.36
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.2.1.3
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
is: SBO:0000176
kinetic law: MODEL1310110011#
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_9eb1d6f8_01f8_40a6_9446_dcebcf5919bd
type: Species
is encoded by: hsa:10195
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: ALG3

metaM succ x
name: Succinate
is: CHEBI:30031
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: HMDB00254
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: C00042
type: Species
has only substance units: false
is: SBO:0000247

metaR PSFLIPm
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: false
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
modifier: MODEL1310110011#
name: phosphatidylserine flippase
is described by: ECO:0000269
product: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/3.6.3.1
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_b6452926_0850_40ed_95a0_a94cf57f914d
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q9Y6M9
initial amount: NaN
type: Species
name: NDUFB9
constant: false
has only substance units: false
is encoded by: hsa:4715

metaR EICOSTETCRNt
product: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
modifier: MODEL1310110011#
reactant: MODEL1310110011#
name: transport into the mitochondria (carnitine)
is: SBO:0000185
reversible: false
is described by: ECO:0000000
fast: false

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaM pydx c
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
initial amount: NaN
type: Species
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
is: C00250
initial concentration: 1.0
name: Pyridoxal
is: CHEBI:17310
is: HMDB01545

metaR S6T4g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
modifier: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reversible: false
fast: false
type: Reaction
is described by: ECO:0000000

metaR RE2799C
fast: false
kinetic law: MODEL1310110011#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
name: RE2799
product: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction

metaM retinol 9 cis c
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
is: HMDB06217
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:17336
constant: false
is: SBO:0000247
name: 9-cis-retinol
has only substance units: false
initial amount: NaN

metaM cbasp e
is: HMDB00828
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:32814
is: C00438
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H6N2O5 CHARGE: -2
type: Species
name: N-Carbamoyl-L-aspartate
has only substance units: false

metaR IMPC
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.3
fast: false
product: MODEL1310110011#
reactant: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000176
reversible: true
is described by: ECO:0000269
name: IMP cyclohydrolase

metaR r2130
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110011#
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#

metaR RE2814M
kinetic law: MODEL1310110011#
fast: false
name: RE2814
type: Reaction
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
product: MODEL1310110011#
reversible: true
is: SBO:0000176
is described by: ECO:0000000

metaR TDCRNe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of myristoyl carnitine into extra cellular space
type: Reaction

metaR KHK2
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110011#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.3 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.3
modifier: MODEL1310110011#
name: ketohexokinase (D-xylulose)

http://identifiers.org/biomodels.db/MODEL1310110011#_6ae9add2_82f1_4e8b_b820_63dd142a8651
name: SLC6A12
initial amount: NaN
constant: false
is encoded by: hsa:6539
is: SBO:0000252
is: P48065
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species

metaR XOLTRIOLtm
name: lipid, flip-flop intracellular transport
reversible: true
type: Reaction
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ

metaM hexdicoa c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
boundary condition: false
constant: false
is: HMDB02014
name: hexadecanedioylcoa
is: SBO:0000247
type: Species
initial amount: NaN

metaR r2131
modifier: MODEL1310110011#
fast: false
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
kinetic law: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_297fb17b_69b1_4e72_b681_e8ca2df0a074
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:2882
name: GPX7
constant: false
boundary condition: true
is: Q96SL4

http://identifiers.org/biomodels.db/MODEL1310110011#_aafd268c_40b6_4073_9383_d8131e22249d
boundary condition: true
type: Species
is: P51570
is encoded by: hsa:2584
initial concentration: NaN
name: GALK1
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_e5f60e46_696d_40ea_acc3_c89a0f13b0c7
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:AI761708
name: _AI761708_1_m

metaR PTDCACRNCPT2
product: MODEL1310110011#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
modifier: MODEL1310110011#
name: pentadecanoate transport into the mitochondria
type: Reaction
reactant: MODEL1310110011#
fast: false
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110011#

metaM eicostetcoa c
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: eicosatetranoyl coenzyme A
type: Species
boundary condition: false
is: C16164
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_6cc6739b_0cce_4ac3_a1bc_f278e372cc2c
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:10861
initial concentration: NaN
is: SBO:0000252
is: Q9H2B4
initial amount: NaN
constant: false
name: SLC26A1

metaR FAOXC16DCC14DCx
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16DC-->C14DC)x
type: Reaction

metaR 3DPHBH1
type: Reaction
name: Hydroxylation of 3-Decaprenyl-4-hydroxybenzoate (NADH)
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212 NOTES:Used to make Ubiquinone-10 enzyme has not been identified yet. IT
reversible: false
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaM c226crn m
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
initial concentration: 1.0
constant: false
type: Species
name: cervonyl carnitine
is: HMDB06510
has only substance units: false
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/127055
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_c029760b_1323_4dc6_a8b9_2fde7733e94e
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
name: _AI640625_1_c
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:AI640625

http://identifiers.org/biomodels.db/MODEL1310110011#_ead1e711_c4d9_4f50_a627_15e6dfba4b05
name: NDUFB5
constant: false
is: O43674
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4711
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN

metaR RE0583C
reversible: true
is described by: ECO:0000000
name: RE0583
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
type: Reaction
product: MODEL1310110011#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110011#

metaR r0842
modifier: MODEL1310110011#
reversible: true
name: Postulated transport reaction
is version of: http://identifiers.org/ec-code/1.3.1.72
type: Reaction
kinetic law: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110011#
fast: false
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:

metaR r2132
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_b10d1a2a_f19f_4020_9930_aacd1e72f62f
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: E9KL42
constant: false
name: ACOT1
has only substance units: false
is encoded by: hsa:641371

http://identifiers.org/biomodels.db/MODEL1310110011#_bd7a1c23_314b_439f_94ad_f53fbcaff390
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q7LGC8
is encoded by: hsa:9469
constant: false
type: Species
name: CHST3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_1634bb7a_a9b9_41d3_9b97_c244d29b4d34
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:5152
name: PDE9A
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_124e5dd8_2fb1_412f_b02b_54c61d6a8dee
initial concentration: NaN
has only substance units: false
is: A5JJ20
initial amount: NaN
type: Species
is encoded by: hsa:8671
name: SLC4A4
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_ebd04ead_008e_4c3b_9e95_b5c1068e87eb
name: SUCLG2:SUCLG1
constant: false
has part: Q96I99
has only substance units: false
is encoded by: hsa:8802
boundary condition: true
initial amount: NaN
is encoded by: hsa:8801
is: SBO:0000297
initial concentration: NaN
has part: P53597
type: Species

metaR r0950
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110011#
is: SBO:0000185
name: Facilitated diffusion
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
reversible: false

metaM 3hdeccoa c
is: SBO:0000247
initial amount: NaN
is: HMDB02014
has only substance units: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
initial concentration: 1.0
name: 3-hydroxyhexadecenoylcoa
type: Species
constant: false
boundary condition: false

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaR r2133
reactant: MODEL1310110011#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
kinetic law: MODEL1310110011#
is: SBO:0000185
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false
product: MODEL1310110011#

metaR CO2ter
kinetic law: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: CO2 endoplasmic reticular transport via diffusion
product: MODEL1310110011#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_49b10ce3_fd7d_4f80_a555_52cc28338956
type: Species
is encoded by: hsa:5464
name: PPA1
initial concentration: NaN
has only substance units: false
is: Q15181
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR MMSAD3m
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.27
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
product: MODEL1310110011#
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#

metaR RBFK
modifier: MODEL1310110011#
fast: false
type: Reaction
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.26
is: SBO:0000176
name: riboflavin kinase
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110011#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110011#_980cc757_9905_4fdb_be7f_7e01e1bb0ae4
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: DPYD
constant: false
type: Species
has only substance units: false
is: Q12882
boundary condition: true
is encoded by: hsa:1806

metaR HESTRATRIOLte
reactant: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be exported NJ
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: true
type: Reaction
name: hydroxylated estrogen derivative transport
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_e374ba70_e3fd_4d59_9410_2097a776bfd7
name: PDE1B
is: SBO:0000252
is encoded by: hsa:5153
type: Species
is: Q7Z364
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false

metaR PYDXDH
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.2.3.1
reversible: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.2.3.1 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:IT
product: MODEL1310110011#
name: pyridoxal dehydrogenase
modifier: MODEL1310110011#
is: SBO:0000176

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaR RE3566C
reversible: true
type: Reaction
name: RE3566
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
fast: false
is: SBO:0000176
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000000

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

metaM n2m2nmasn l
has only substance units: false
is: C04946
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C58H96N5O40X CHARGE: 0
type: Species
initial amount: NaN
constant: false
boundary condition: false
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R

metaR r0539
reversible: true
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
kinetic law: MODEL1310110011#
is: SBO:0000176
modifier: MODEL1310110011#
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.1.34
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_8268ef5d_27b4_4849_97a0_fe9d84214192
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
name: ACADSB
constant: false
is encoded by: hsa:36
initial amount: NaN
is: P45954

metaR FAOXC2251836m
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of fatty acid
kinetic law: MODEL1310110011#
type: Reaction
fast: false
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110011#
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
is described by: ECO:0000000

metaR HIBDm
reactant: MODEL1310110011#
fast: false
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
is described by: ECO:0000269
type: Reaction
reversible: true
modifier: MODEL1310110011#
is: SBO:0000176
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.1.31
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
kinetic law: MODEL1310110011#

metaR r2136
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
kinetic law: MODEL1310110011#
reversible: false
type: Reaction
product: MODEL1310110011#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
modifier: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_c979865e_dd14_4121_98ff_217e29f85a37
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: P30837
type: Species
is encoded by: hsa:219
name: ALDH1B1

metaR DURAD2
reversible: true
product: MODEL1310110011#
modifier: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.1.2
name: dihydrothymin dehydrogenase (NADP)
kinetic law: MODEL1310110011#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
type: Reaction

metaR C161CRNt
type: Reaction
product: MODEL1310110011#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
reversible: false
is: SBO:0000185
reactant: MODEL1310110011#
name: C161 transport into the mitochondria

metaM cytd c
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
boundary condition: false
has only substance units: false
is: HMDB00089
type: Species
initial amount: NaN
name: Cytidine
is: CHEBI:17562
is: C00475

http://identifiers.org/biomodels.db/MODEL1310110011#_072bd7cc_4d5f_40de_9366_0078b1fac0a8
type: Species
initial concentration: NaN
is encoded by: hsa:2348
has only substance units: false
boundary condition: true
initial amount: NaN
name: FOLR1
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_6a08ab7a_6e79_40c3_95b5_a712dbaf3200
initial concentration: NaN
has only substance units: false
is: Q9H845
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: ACAD9
is encoded by: hsa:28976
type: Species

metaR AICART
modifier: MODEL1310110011#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.3
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
type: Reaction
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
reversible: true
kinetic law: MODEL1310110011#

metaM 4aphdob c
is: CHEBI:58147
type: Species
boundary condition: false
initial concentration: 1.0
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
is: SBO:0000247
is: HMDB00978
has only substance units: false
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_7afb1417_d446_4b46_8752_93e3c8cc8ea3
is encoded by: hsa:29920
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
name: PYCR2
has only substance units: false
type: Species
is: Q96C36

metaM fn2m2masn g
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
is: CHEBI:32984
is: SBO:0000247
type: Species
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaM ddcacoa m
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: HMDB03571
is: CHEBI:57375
name: Dodecanoyl-CoA (n-C12:0CoA)
is: SBO:0000247
is: C01832

http://identifiers.org/biomodels.db/MODEL1310110011#_44d9123d_65ea_46c5_a6b4_9514384ad0f1
is: SBO:0000252
boundary condition: true
name: DHFR
has only substance units: false
is: P00374
type: Species
initial amount: NaN
is encoded by: hsa:1719
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_f01b9341_b9ca_41f0_b642_8c36e0f6b66b
initial concentration: NaN
type: Species
is encoded by: hsa:AI090874
initial amount: NaN
constant: false
name: _AI090874_1_c
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR r2137
reactant: MODEL1310110011#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110011#
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
kinetic law: MODEL1310110011#
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_0ae389f7_415b_4e64_a2dd_9e3770842512
constant: false
has only substance units: false
name: PIGC
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q92535
boundary condition: true
is encoded by: hsa:5279

http://identifiers.org/biomodels.db/MODEL1310110011#_57a5f7c3_4d15_428a_9f00_e6adc05b999a
type: Species
constant: false
initial concentration: NaN
boundary condition: true
name: GCK
is encoded by: hsa:2645
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM mpdol L c
type: Species
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C1300H2128N20O220P20 CHARGE: -20 INCHI: InChI=1S/C47H82N2O22P2/c1-26(2)13-9-14-27(3)15-10-16-28(4)17-11-18-29(5)19-12-20-30(6)21-22-64-72(60,61)71-73(62,63)70-46-37(49-32(8)54)40(57)43(35(25-52)67-46)68-45-36(48-31(7)53)39(56)44(34(24-51)66-45)69-47-42(59)41(58)38(55)33(23-50)65-47/h13,15,17,19,30,33-47,50-52,55-59H,9-12,14,16,18,20-25H2,1-8H3,(H,48,53)(H,49,54)(H,60,61)(H,62,63)/b27-15+,28-17+,29-19+/t30?,33-,34-,35-,36-,37-,38-,39-,40-,41+,42+,43-,44-,45+,46-,47+/m1/s1
is: CHEBI:18396

metaM sarcs m
type: Species
is: HMDB00271
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
is: SBO:0000247
is: C00213
name: Sarcosine
is: CHEBI:15611
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_77432ed6_19b9_4731_9a66_dfb6f6866758
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: P54868
name: HMGCS2
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3158

metaM succ c
is: HMDB00254
is: CHEBI:30031
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
name: Succinate
boundary condition: false
is: C00042
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042

http://identifiers.org/biomodels.db/MODEL1310110011#_4ceecf39_4a3d_4989_9235_2e04a217a6ea
is: P54819
constant: false
has only substance units: false
type: Species
initial concentration: NaN
name: AK2
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:204

metaM rbt e
initial concentration: 1.0
is: HMDB00508
initial amount: NaN
name: D-ribitol
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
type: Species
is: CHEBI:15963
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_8df6d96b_4e35_49fa_b568_066192de9ff5
is encoded by: hsa:55163
is: Q9NVS9
is: SBO:0000252
initial amount: NaN
name: PNPO
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species

metaR r2139
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110011#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
product: MODEL1310110011#

metaR HDCACBP
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM sebacid x
initial concentration: 1.0
type: Species
notes: FORMULA: C10H16O4 CHARGE: -2
is: HMDB00792
constant: false
boundary condition: false
initial amount: NaN
name: sebacicacid
is: C08277
is: SBO:0000247
has only substance units: false

metaM rbt c
boundary condition: false
initial concentration: 1.0
is: CHEBI:15963
constant: false
is: HMDB00508
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: SBO:0000247
type: Species
name: D-ribitol

metaM dd2coa c
constant: false
initial concentration: 1.0
name: trans-Dodec-2-enoyl-CoA
is: HMDB03712
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C33H52N7O17P3S CHARGE: -4

metaR FAOXC18480m
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
fast: false
reversible: false
modifier: MODEL1310110011#
reactant: MODEL1310110011#
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM octd11ecoa c
is: C08277
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: HMDB00792
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
name: 11-octadecenoylcoa
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_cc435af0_78ff_4cca_be28_21b9d7824584
initial concentration: NaN
type: Species
name: _X63359_1_c
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:X63359
is: SBO:0000252
constant: false

metaR HISSNAT5tc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR L LACt2r
modifier: MODEL1310110011#
is: SBO:0000185
type: Reaction
reversible: true
fast: false
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000269
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
name: L-lactate reversible transport via proton symport

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

metaR MI1PS
fast: false
reactant: MODEL1310110011#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.5.1.4
is described by: ECO:0000269
kinetic law: MODEL1310110011#
product: MODEL1310110011#
modifier: MODEL1310110011#
name: myo-Inositol-1-phosphate synthase
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (51477.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 5.5.1.4 Confidence Level: 4 AUTHORS: PMID:12941308 NOTES:NCD

metaR RE2658R
type: Reaction
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
product: MODEL1310110011#
is: SBO:0000176
is described by: ECO:0000000
name: RE2658
fast: false
reversible: true
kinetic law: MODEL1310110011#

metaR FACOAL160i
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
fast: false
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
kinetic law: MODEL1310110011#
product: MODEL1310110011#
modifier: MODEL1310110011#
name: C160 fatty acid activation
type: Reaction

metaR UMPK6n
kinetic law: MODEL1310110011#
reversible: true
product: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (dCTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110011#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110011#_6884495d_7006_435f_8e43_5e602321eb12
constant: false
is encoded by: hsa:1603
initial concentration: NaN
is: Q53G02
name: DAD1
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaM CE5121 m
constant: false
name: trans-3-decenoyl-CoA
is: CHEBI:57449
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR NAIt
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
product: MODEL1310110011#
type: Reaction
fast: false
modifier: MODEL1310110011#
is: SBO:0000185
name: Na+ / iodide cotransport
reversible: true
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_00d0f6ae_de80_4971_8286_05787a2e8f46
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1595
name: CYP51A1
is: Q16850
type: Species
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_31f08fa5_4b39_46cb_8550_107d1a2271c8
type: Species
initial amount: NaN
boundary condition: true
is: Q6ZWP6
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: ACAD8
is encoded by: hsa:27034

metaM n2m2nmasn e
has only substance units: false
type: Species
is: C04946
notes: FORMULA: C58H96N5O40X CHARGE: 0
constant: false
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_306291bd_51f8_4b32_bd18_dbe8f6c1f2d0
boundary condition: true
is: Q9Y6T7
is encoded by: hsa:1607
type: Species
name: DGKB
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_064ae836_ed87_453f_a2dc_3773517c1f0c
is: P55084
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3032
type: Species
constant: false
name: HADHB
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_da7ec430_6ebb_42bd_ae65_03424589e24f
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
name: COX1
constant: false
initial concentration: NaN
is: Q7GXY8
is: SBO:0000252
is encoded by: hsa:4512

metaR AK2LGCHOLt
name: 1-alkyl 2-acylglycerol 3-phosphocholine transport
is described by: ECO:0000269
product: MODEL1310110011#
is: SBO:0000185
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.1.1.21 Confidence Level: 2 AUTHORS: PMID:2004782,PMID:2253271,PMID:8106516 NOTES:

metaM gacpail hs c
name: glucosaminyl-acylphosphatidylinositol
constant: false
is: C00092
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:61548
is: HMDB01401
type: Species
has only substance units: false

metaM oh1 e
has only substance units: false
is: SBO:0000247
is: HMDB01039
name: hydroxide ion
is: C01328
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: HO CHARGE: -1

metaR RE2069C
reactant: MODEL1310110011#
name: RE2069
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
is: SBO:0000176
reversible: true
product: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#

metaM didp c
initial concentration: 1.0
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
type: Species
is: CHEBI:28823
constant: false
is: HMDB03536
initial amount: NaN
name: dIDP
has only substance units: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_d9883686_cff0_4519_8e43_68365c3b3481
is: Q4W5N8
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:51166
initial concentration: NaN
constant: false
name: AADAT

http://identifiers.org/biomodels.db/MODEL1310110011#_355daab5_9236_471f_8e4d_48465a208485
type: Species
name: AK2
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:204

metaM ivcoa c
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
boundary condition: false
type: Species
is: SBO:0000247
name: Isovaleryl-CoA
is: HMDB01113

metaR EX dhdascb LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dehydroascorbide(1-)
type: Reaction

metaR HEXCCOAtx
kinetic law: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
is: SBO:0000185
reactant: MODEL1310110011#
type: Reaction
product: MODEL1310110011#
reversible: true
name: fatty acid intracellular transport

metaM trdox m
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
name: Oxidized thioredoxin
is: CHEBI:18191
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
has only substance units: false
boundary condition: false
constant: false

metaM c10dc c
is: SBO:0000247
boundary condition: false
name: sebacoyl carnitine
is: HMDB13325
notes: FORMULA: C17H30NO6 CHARGE: -1
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false

metaR RE3272N
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
is: SBO:0000176
reactant: MODEL1310110011#
name: RE3272
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110011#
fast: false
type: Reaction
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_b26f1ac1_bdac_48cc_a05e_899e0e8d7067
name: PEMT
initial amount: NaN
type: Species
is encoded by: hsa:10400
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false

metaM dhcholoylcoa x
type: Species
is: SBO:0000247
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
initial amount: NaN
is: HMDB06895
constant: false
initial concentration: 1.0
is: CHEBI:27393
boundary condition: false
has only substance units: false

metaR r0531
kinetic law: MODEL1310110011#
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
product: MODEL1310110011#
modifier: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.34

metaM 2maacoa m
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:57335
constant: false
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
boundary condition: false
type: Species
initial concentration: 1.0
name: 2-methylacetoacetyl-CoA(4-)
is: HMDB01157

http://identifiers.org/biomodels.db/MODEL1310110011#_43d66ca9_34d8_4335_b094_6fad1481296c
initial amount: NaN
name: PLCB1
is encoded by: hsa:23236
is: SBO:0000252
is: Q9NQ66
type: Species
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_ef54c405_81bf_4acf_95c5_d9572836abeb
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is: P30613
is encoded by: hsa:5313
initial concentration: NaN
name: PKLR

metaM 3dphb m
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C57H85O3 CHARGE: -1 INCHI: InChI=1/C57H86O3/c1-44(2)21-12-22-45(3)23-13-24-46(4)25-14-26-47(5)27-15-28-48(6)29-16-30-49(7)31-17-32-50(8)33-18-34-51(9)35-19-36-52(10)37-20-38-53(11)39-40-54-43-55(57(59)60)41-42-56(54)58/h21,23,25,27,29,31,33,35,37,39,41-43,58H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,59,60)/b45-23+,46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+
type: Species
name: 3-Decaprenyl-4-hydroxybenzoate
is: HMDB06251
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_88f58574_c899_4008_8b03_0b9db3567615
name: B4GALT1
type: Species
constant: false
is encoded by: hsa:2683
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: P15291
has only substance units: false
boundary condition: true

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaR C12DCACOT
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of dodecanedioyl coa for release into cytosol
type: Reaction

metaR ARACHCRNt
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110011#
modifier: MODEL1310110011#
fast: false
type: Reaction
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110011#
reversible: false
kinetic law: MODEL1310110011#

metaM ptth m
initial concentration: 1.0
name: pantetheine
is: SBO:0000247
constant: false
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:16753
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: HMDB03426

metaM HC00900 c
boundary condition: false
initial concentration: 1.0
is: CHEBI:30860
is: SBO:0000247
name: Methylmalonate
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaR GLYt7 311 r
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000006
modifier: MODEL1310110011#
name: glycine reversible transport via sodium and chloride symport (3:1:1)
fast: false
reactant: MODEL1310110011#

metaM c10dc e
notes: FORMULA: C17H30NO6 CHARGE: -1
constant: false
is: HMDB13325
is: SBO:0000247
name: sebacoyl carnitine
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species

metaM pac c
name: phenylacetate
is: CHEBI:18401
initial amount: NaN
is: SBO:0000247
is: HMDB00209
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
constant: false
type: Species
boundary condition: false

metaM damp c
is: HMDB00905
name: dAMP(2-)
is: SBO:0000247
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58245
type: Species

metaM 7dhf e
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB06559
boundary condition: false
name: heptaglutamyl folate (DHF)
constant: false

metaM c226crn c
is: HMDB06510
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
boundary condition: false
has only substance units: false
name: cervonyl carnitine
is: http://identifiers.org/pubchem.compound/127055
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species

metaM CE2838 e
boundary condition: false
type: Species
name: maltononaose
initial concentration: 1.0
constant: false
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
initial amount: NaN
is: SBO:0000247
is: C01936
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false

metaM g3p c
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
is: C00661
type: Species
is: HMDB01112
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3930
initial concentration: 1.0
is: CHEBI:58027
boundary condition: false
name: Glyceraldehyde 3-phosphate

metaM prostge1 e
name: prostaglandin E1(1-)
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
constant: false
initial concentration: 1.0
is: HMDB01442
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:57397

metaR FAOXC185m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

metaM HC02213 e
is: SBO:0000247
is: CHEBI:28031
initial amount: NaN
initial concentration: 1.0
name: prostaglandin-e3
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
constant: false
boundary condition: false
type: Species
has only substance units: false

metaR EX fmn LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for FMN
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_5e684610_57fa_4828_a772_ea103bcffeee
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI697028
has only substance units: false
initial amount: NaN
name: _AI697028_1_m

metaR NCNt
reversible: true
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
product: MODEL1310110011#
is: SBO:0000185
modifier: MODEL1310110011#
is described by: ECO:0000269
kinetic law: MODEL1310110011#
type: Reaction
name: Na+/Ca2+-NH4+ exchange
reactant: MODEL1310110011#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_3da5700f_1a1e_4328_b12b_7da50bdea325
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: DGKI
is: O75912
is: SBO:0000252
is encoded by: hsa:9162
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_6ee44b13_641d_4e2d_b8a9_a3e4fd3771b3
has only substance units: false
constant: false
is encoded by: hsa:H45672
initial amount: NaN
name: _H45672_1_m
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN

metaR r2411
is described by: ECO:0000000
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is: SBO:0000185
product: MODEL1310110011#
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_f58d1e10_719b_4394_8c8c_3031f21628d5
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q16842
name: ST3GAL2
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:6483

metaR DOLPGT2 Ler
is: SBO:0000176
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
product: MODEL1310110011#
reversible: false
type: Reaction
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.4.1.265

metaM gal1p c
is: HMDB00645
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:58336
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_e12b79ae_2a1a_45a2_a447_0099b31f92d0
has only substance units: false
type: Species
constant: false
boundary condition: true
initial concentration: NaN
name: FOLR1
is encoded by: hsa:2348
initial amount: NaN
is: SBO:0000252

metaR NH4tp
name: ammonia peroxisomal transport
product: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110011#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_a25c6c65_8b6a_48ec_b54b_1b57ba3cb6f7
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:55229
is: SBO:0000252
is: Q9NVE7
name: PANK4
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_1ee828b6_a9f6_4acc_a3e5_34c863c6e7e3
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1718
initial amount: NaN
has only substance units: false
name: DHCR24
is: Q15392
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_b8d18ee3_1684_476a_89d9_6a3c5899ac47
name: COX5A
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:9377
is: P20674
is: SBO:0000252

metaM didp n
is: SBO:0000247
name: dIDP
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
boundary condition: false
constant: false
type: Species
is: HMDB03536
is: CHEBI:28823
has only substance units: false

metaR DCYTt
product: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
fast: false
reactant: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reversible: true
name: deoxycytidine transport via diffusion

metaR EX c16dc
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecanedioic acid mono-L-carnitine ester
type: Reaction

metaM sarcs c
notes: FORMULA: C3H7NO2 CHARGE: 0
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
is: C00213
boundary condition: false
is: HMDB00271
name: Sarcosine
is: CHEBI:3513

metaR LPS3
name: lipase
is described by: ECO:0000000
product: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.23
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (11343.1) or (11343.2) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.23 Confidence Level: 4 AUTHORS: PMID:9495531 NOTES:NJ

metaM pan4p m
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB01416
is: CHEBI:47942
type: Species
name: pantetheine 4'-phosphate(2-)
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial amount: NaN

metaM tsul c
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: CHEBI:16094
initial amount: NaN
type: Species
name: thiosulfate(2-)
is: SBO:0000247
is: HMDB00257

metaM pe hs r
initial amount: NaN
type: Species
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
name: phosphatidylethanolamine
boundary condition: false
is: CHEBI:16038
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM succ m
is: C00042
name: Succinate
is: CHEBI:30031
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00254
initial amount: NaN
is: SBO:0000247

metaM HC01406 m
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
boundary condition: false
is: CHEBI:28264
constant: false
initial concentration: 1.0
name: 3-Oxooctanoyl-CoA

metaR GUAt
name: Guanine transport
is described by: ECO:0000269
reactant: MODEL1310110011#
reversible: true
product: MODEL1310110011#
fast: false
type: Reaction
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
modifier: MODEL1310110011#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_595f7494_f36e_4ee2_bdee_25a58198d344
is: Q9BRC7
has only substance units: false
type: Species
constant: false
initial concentration: NaN
name: PLCD4
is encoded by: hsa:84812
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_0bbd6ad0_9b71_4ac4_8b72_27afc273408d
is encoded by: hsa:10166
name: SLC25A15
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: Q9Y619
boundary condition: true

metaR AG13T2g
modifier: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
is: SBO:0000176
product: MODEL1310110011#
reactant: MODEL1310110011#

metaM hexdicoa r
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
is: SBO:0000247
name: hexadecanedioylcoa
boundary condition: false
type: Species
initial concentration: 1.0
is: C08260
has only substance units: false
is: HMDB00672
initial amount: NaN
constant: false

metaM dlnlcgcrn m
has only substance units: false
name: dihomo-gamma-linolenyl carnitine
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
boundary condition: false
is: CHEBI:16004
type: Species
is: HMDB01311

http://identifiers.org/biomodels.db/MODEL1310110011#_eb04f9ff_1476_433b_8f48_4cfe5eef9739
type: Species
initial amount: NaN
is encoded by: hsa:10327
name: AKR1A1
is: SBO:0000252
is: P14550
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN

metaM cytd e
has only substance units: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
name: Cytidine
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:17562
boundary condition: false
is: HMDB00089
constant: false
is: C00475
initial amount: NaN

metaM g1m8mpdol L r
is: C05870
has only substance units: false
initial amount: NaN
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
notes: FORMULA: C1840H3028N20O670P20 CHARGE: -20
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR G6PDH2rer
is version of: http://identifiers.org/ec-code/1.1.1.47
is described by: ECO:0000269
modifier: MODEL1310110011#
product: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
fast: false
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum

metaR AG13T14g
kinetic law: MODEL1310110011#
fast: false
product: MODEL1310110011#
is: SBO:0000176
modifier: MODEL1310110011#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110011#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149

metaR EX c101crn
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_3fb2510e_f926_40cc_ac8d_d29755596571
is encoded by: hsa:587
has only substance units: false
name: BCAT2
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: O15382

metaR FAOXC141C141OHm
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C14:1OH)m
type: Reaction

metaR DOLPGT1 Ler
fast: false
modifier: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
kinetic law: MODEL1310110011#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.267
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)

metaR r0853
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
reversible: false
product: MODEL1310110011#
name: Facilitated diffusion
is described by: ECO:0000000
fast: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_c4a41a90_c61f_495f_a2d7_ee48a6752300
type: Species
is encoded by: hsa:51205
is: Q9NPH0
is: SBO:0000252
boundary condition: true
name: ACP6
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

metaM acetol c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: hydroxyacetone
type: Species
is: HMDB06961
is: CHEBI:27957
constant: false
boundary condition: false
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
has only substance units: false

metaR DMNONCOACRNCPT1
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110011#
name: DMNONCOACRNCPT1
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#

metaM rib D e
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
name: D-ribose
initial amount: NaN
is: CHEBI:16988
is: HMDB00283

metaR r0618
is: SBO:0000176
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
is described by: ECO:0000000
product: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2

metaM octdececoa m
has only substance units: false
is: SBO:0000247
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
is: HMDB06294
constant: false
type: Species
initial amount: NaN
name: octadecenoylcoa

metaM udpglcur r
initial amount: NaN
name: UDP-D-glucuronate
constant: false
type: Species
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: CHEBI:58052
initial concentration: 1.0
is: SBO:0000247
is: C00167
boundary condition: false
has only substance units: false
is: HMDB00935

metaR r1380
is described by: ECO:0000000
product: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
reversible: true
kinetic law: MODEL1310110011#
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
type: Reaction
is: SBO:0000176

metaM acnam n
is: CHEBI:35418
name: N-acetylneuraminate
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: HMDB00230

http://identifiers.org/biomodels.db/MODEL1310110011#_e17a550e_b46a_4ffb_8e8e_facfa9ab2c68
initial concentration: NaN
is encoded by: hsa:374291
boundary condition: true
type: Species
is: O75251
constant: false
initial amount: NaN
is: SBO:0000252
name: NDUFS7
has only substance units: false

metaM gpi prot hs r
constant: false
initial concentration: 1.0
name: {[(Prot-PE-Man),(PE)-Man],[PE]}-Man-GlcN-acylPI
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00220
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2X CHARGE: 0
is: C00249
has only substance units: false
is: CHEBI:7896
type: Species

metaR r1907
reversible: false
type: Reaction
product: MODEL1310110011#
is: SBO:0000185
reactant: MODEL1310110011#
fast: false
modifier: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM HC01434 x
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
constant: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
is: CHEBI:58931
initial amount: NaN
name: oxalatosuccinate(3-)
initial concentration: 1.0

metaM ivcoa m
initial amount: NaN
name: Isovaleryl-CoA
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
constant: false
is: HMDB01113
is: CHEBI:57345
type: Species
is: SBO:0000247

metaR RE1522M
reactant: MODEL1310110011#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
modifier: MODEL1310110011#
name: RE1522
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
kinetic law: MODEL1310110011#

metaR PI45P5Pn
reactant: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000176
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase, nuclear
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:NCD
reversible: false
type: Reaction

metaR ACNMLr
product: MODEL1310110011#
is: SBO:0000176
type: Reaction
reversible: true
kinetic law: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 4.1.3.3 Confidence Level: 2 AUTHORS: NOTES:JLR
reactant: MODEL1310110011#
fast: false
name: N-Acetylneuraminate lyase (reversible)

metaM hexdicoa x
name: hexadecanedioylcoa
is: HMDB03932
constant: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
has only substance units: false
type: Species
initial concentration: 1.0
is: C05258
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR PHEMEt
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
type: Reaction
fast: false
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
name: heme transport

metaR r0616
reversible: true
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110011#
modifier: MODEL1310110011#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2

http://identifiers.org/biomodels.db/MODEL1310110011#_7da5193b_e523_4992_a3ea_6dc16d0592f9
name: PIGB
is encoded by: hsa:9488
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is: Q92521
constant: false

metaR HISD
name: histidase
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/4.3.1.3
type: Reaction
reactant: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000176
fast: false

metaM ptth c
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: HMDB03426
has only substance units: false
constant: false
name: pantetheine
is: CHEBI:16753
type: Species

metaR G12MT1 L
is: SBO:0000176
is described by: ECO:0000000
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
kinetic law: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110011#
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_a283a22e_1eee_4444_ba8c_3a9ff4d7122a
name: RPE
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is: Q96AT9
is encoded by: hsa:6120

metaR PE HSter
reversible: true
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
name: phosphatidylethanolamine scramblase
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:

metaR DMNONCRNt
type: Reaction
reversible: true
kinetic law: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: 4,8 dimethylnonanoyl carnitine transport (mitochondria)
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
product: MODEL1310110011#

metaR DOLPH Ler
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
product: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
reversible: false
name: Dolichol-phosphate phosphohydrolase, human (liver)
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110011#

metaM udpg r
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:58367
initial concentration: 1.0
is: HMDB00286

metaM 2mcit e
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:15598
constant: false
initial concentration: 1.0
name: 2-methylcitrate(3-)
is: HMDB00379
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3

metaM fad c
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: SBO:0000247
is: HMDB01248
is: CHEBI:16238
is: C00016
constant: false
boundary condition: false
has only substance units: false
name: Flavin adenine dinucleotide oxidized

metaR BAAT3x
is: SBO:0000176
is described by: ECO:0000304
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:third version analog added as per KEGG NJ
fast: false
kinetic law: MODEL1310110011#
name: bile acid Coenzyme A: amino acid N-acyltransferase
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: false
modifier: MODEL1310110011#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_6dc3984c_501b_4a66_a9ff_76d988893973
is: SBO:0000252
initial amount: NaN
type: Species
is: Q6IB80
constant: false
is encoded by: hsa:4709
initial concentration: NaN
has only substance units: false
name: NDUFB3
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_15748e34_2681_4b49_bc4b_df1e28c4fb9b
name: GNPNAT1
initial concentration: NaN
is: Q96EK6
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:64841
constant: false
is: SBO:0000252
boundary condition: true

metaM uacgam c
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
has only substance units: false
constant: false
is: HMDB00290
is: SBO:0000247
is: CHEBI:57705
initial amount: NaN
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
type: Species
boundary condition: false
initial concentration: 1.0

metaR HTDCRNe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-tetradecanoyl carnitine into extra cellular space
type: Reaction

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaR r0553
is described by: ECO:0000000
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
fast: false
reversible: true
type: Reaction
product: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is: SBO:0000176
reactant: MODEL1310110011#

metaR r0614
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
product: MODEL1310110011#
reversible: true
reactant: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
fast: false
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
kinetic law: MODEL1310110011#

metaM HC02175 c
boundary condition: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: caprate
is: CHEBI:27689
initial concentration: 1.0
constant: false

metaR PRO1xm
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.99.8
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD
product: MODEL1310110011#
reactant: MODEL1310110011#
name: proline oxidase (NAD), mitochondrial
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
reversible: false
is described by: ECO:0000254

metaR MCLACCYSR
is: SBO:0000176
name: 3-mercaptolactate:cysteine reductase
product: MODEL1310110011#
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
reversible: false

metaR GPIAT
product: MODEL1310110011#
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
name: glucosaminylphosphatidyl inositol acetyltransferase
reactant: MODEL1310110011#
reversible: false

metaM ala B e
is: HMDB00056
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
name: beta-alanine
is: CHEBI:16958

metaR r1384
reversible: true
product: MODEL1310110011#
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
fast: false
is described by: ECO:0000000
name: Guanosine aminohydrolase EC:3.5.4.15

metaM HC02180 e
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
name: thromboxane-b2
initial amount: NaN
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
constant: false
initial concentration: 1.0
is: CHEBI:28728

metaM glyc e
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17754
name: Glycerol
is: SBO:0000247
is: HMDB00131
is: C00116
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_9b61002a_8be0_4fa8_8b4b_b0c1f460081a
is: SBO:0000252
constant: false
initial concentration: NaN
name: PMVK
is encoded by: hsa:10654
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q6FGV9

http://identifiers.org/biomodels.db/MODEL1310110011#_977e73c0_eca4_463b_82c1_3f9ff613adea
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: ACAA2
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:10449
is: P42765

metaM 2mcit c
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15598
initial amount: NaN
name: 2-methylcitrate(3-)
constant: false
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
is: HMDB00379

metaR GGT6
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
product: MODEL1310110011#
reversible: true
reactant: MODEL1310110011#
fast: false
name: Gamma-glutamyltransferase

metaM CE2417 m
boundary condition: false
is: CHEBI:28387
constant: false
type: Species
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
is: HMDB11123
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
initial concentration: 1.0

metaM fad e
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16238
boundary condition: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
type: Species
is: SBO:0000247
is: HMDB01248
has only substance units: false
is: C00016
constant: false
name: Flavin adenine dinucleotide oxidized

http://identifiers.org/biomodels.db/MODEL1310110011#_ccbfb2d8_b2ce_45d6_a14f_fe2895a7acf5
is encoded by: hsa:BG035985
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
name: _BG035985_1_c
type: Species

metaM CE5788 e
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB02710
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:27485
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
name: kinetensin 1-7
constant: false

metaR r1381
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
reactant: MODEL1310110011#
is described by: ECO:0000000
reversible: true
fast: false

metaR r0552
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.5.1
product: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
reversible: true
is: SBO:0000176
modifier: MODEL1310110011#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110011#_1c4b06cb_1c56_4cae_b860_8a0edba2f1bd
constant: false
is: SBO:0000252
initial amount: NaN
name: _AI348006_1_c
is encoded by: hsa:AI348006
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR RE1898C
name: RE1898
product: MODEL1310110011#
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110011#_b639f589_575a_4092_bb8d_618bf0fb61ef
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:3033
is: Q16836
name: HADH
boundary condition: true
initial concentration: NaN

metaM HC02175 e
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
is: CHEBI:27689
has only substance units: false
name: caprate
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_a119da7c_36eb_42fa_8aee_1ba0d7d0d27d
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: Q9Y666
type: Species
name: SLC12A7
has only substance units: false
is encoded by: hsa:10723

metaM HC02180 c
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
type: Species
constant: false
is: CHEBI:28728
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: thromboxane-b2

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaM ala B c
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: SBO:0000247
is: CHEBI:16958
initial amount: NaN
name: beta-alanine
initial concentration: 1.0
is: HMDB00056
constant: false
boundary condition: false
has only substance units: false

metaR 5ADTSTSTERONEte
reactant: MODEL1310110011#
product: MODEL1310110011#
name: 5 alpha dihydrotesterone transport
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
kinetic law: MODEL1310110011#
type: Reaction
reversible: true

metaM glyc c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17754
has only substance units: false
name: Glycerol
is: HMDB00131
boundary condition: false
type: Species
constant: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: C00116

metaM lnlccrn m
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
name: Linoleyl carnitine
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB06469
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_899c0bfc_e266_4fe9_a78b_673f3341a94b
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: P06865
is encoded by: hsa:3073
constant: false
boundary condition: true
name: HEXA

metaM HC01434 m
initial amount: NaN
constant: false
is: CHEBI:58931
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: oxalatosuccinate(3-)
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_020c4f61_8c4a_4f26_a44c_a23078f8e0c9
name: PDE5A
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:8654
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR r1492
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
name: Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaR O2Stm
name: superoxide anion transport via diffusion (mitochondria)
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110011#
fast: false
type: Reaction
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
product: MODEL1310110011#
reversible: true

metaR r0611
product: MODEL1310110011#
is described by: ECO:0000000
name: ITP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.2.3.1
modifier: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251 NOTES:

metaR RE3243R
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
kinetic law: MODEL1310110011#
type: Reaction
product: MODEL1310110011#
name: RE3243
reactant: MODEL1310110011#
modifier: MODEL1310110011#
fast: false
is: SBO:0000176
reversible: true
is described by: ECO:0000000

metaM octdececoa c
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
has only substance units: false
name: octadecenoylcoa
boundary condition: false
is: HMDB06351
initial amount: NaN
initial concentration: 1.0

metaM tdcoa m
initial amount: NaN
type: Species
is: SBO:0000247
is: C02593
name: Tetradecanoyl-CoA (n-C14:0CoA)
initial concentration: 1.0
is: CHEBI:57385
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: HMDB01521

metaM nrvnc c
is: SBO:0000247
constant: false
is: HMDB02368
name: nervonate
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
is: CHEBI:32392
boundary condition: false

metaR TETDEC2CRNe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of tetradecadienoyl carnitine into extra cellular space
type: Reaction

metaR ECOAH1m
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
kinetic law: MODEL1310110011#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
is version of: http://identifiers.org/ec-code/4.2.1.18
product: MODEL1310110011#
modifier: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is described by: ECO:0000304

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_a98efd2c_20c6_4b09_9768_1c28456a46a1
boundary condition: true
type: Species
is: SBO:0000252
name: SUOX
initial amount: NaN
is encoded by: hsa:6821
has only substance units: false
initial concentration: NaN
constant: false
is: P51687

http://identifiers.org/biomodels.db/MODEL1310110011#_ba0ad0bb_ce64_421c_ac88_a374b0f2ada7
name: NDUFA13
has only substance units: false
is encoded by: hsa:51079
type: Species
is: Q9P0J0
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_47b77b1f_405d_44d7_945c_fc9353742c60
boundary condition: true
is encoded by: hsa:AL038231
initial amount: NaN
constant: false
initial concentration: NaN
name: _AL038231_1_c
type: Species
has only substance units: false
is: SBO:0000252

metaR r1493
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
name: Utilized transport
fast: false
type: Reaction
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15845416 NOTES:
is described by: ECO:0000000
product: MODEL1310110011#

metaR r0610
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251,PMID:193556,PMID:2987258,PMID:6091737 NOTES:
fast: false
reactant: MODEL1310110011#
name: CTP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
kinetic law: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110011#

metaR EBP1r
type: Reaction
modifier: MODEL1310110011#
reversible: false
is version of: http://identifiers.org/ec-code/5.3.3.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (10682.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 4 AUTHORS: PMID:10391219 NOTES:involved in lanosterol -> cholesterol pathway NJ
kinetic law: MODEL1310110011#
is described by: ECO:0000134
fast: false
reactant: MODEL1310110011#
name: 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase
product: MODEL1310110011#

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaR GLCter
is: SBO:0000185
kinetic law: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
reversible: true
is described by: ECO:0000000
fast: false
name: glucose transport, endoplasmic reticulum
type: Reaction
reactant: MODEL1310110011#

metaM ksi pre9 g
is: C00130
boundary condition: false
is: HMDB00175
constant: false
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 9
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
is: SBO:0000247
initial concentration: 1.0

metaM uacgam g
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: HMDB00290
initial amount: NaN
constant: false
is: CHEBI:57705
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043

http://identifiers.org/biomodels.db/MODEL1310110011#_3c0df97e_24e2_4bdc_9085_9a552d16e4cd
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:4124
is: Q16706
initial amount: NaN
initial concentration: NaN
name: MAN2A1
has only substance units: false
boundary condition: true

metaM ksi pre24 g
is: HMDB00175
has only substance units: false
is: C00130
name: keratan sulfate I biosynthesis, precursor 24
initial amount: NaN
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:58053
type: Species
boundary condition: false

metaM c12dccoa c
is: HMDB00623
boundary condition: false
name: dodecanedioylcoa
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_3f96e332_1586_407f_9543_402e5af939c7
name: ENPP1
type: Species
is: SBO:0000252
is encoded by: hsa:5167
initial amount: NaN
boundary condition: true
is: P22413
constant: false
has only substance units: false
initial concentration: NaN

metaR MI145PK
is version of: http://identifiers.org/ec-code/2.7.1.127
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
name: inositol-1,4,5-trisphosphate 3-kinase
modifier: MODEL1310110011#
reversible: false

metaM ksii core2 pre5 g
is: HMDB00175
boundary condition: false
type: Species
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 5
initial amount: NaN
constant: false
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: SBO:0000247
initial concentration: 1.0
is: C00130
is: CHEBI:58053

metaM oh1 c
initial amount: NaN
constant: false
type: Species
boundary condition: false
is: C01328
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: HO CHARGE: -1
is: HMDB01039
name: hydroxide ion

http://identifiers.org/biomodels.db/MODEL1310110011#_5a3d98ce_222d_42c0_85c8_b8d3ef3faacb
type: Species
is encoded by: hsa:1103
is: SBO:0000252
name: CHAT
boundary condition: true
is: Q6LEN5
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN

metaR 5ADTSTSTERONEtr
is described by: ECO:0000000
name: 5 alpha dihydrotesterone intracellular transport
product: MODEL1310110011#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
reversible: true
fast: false

metaR MI1PP
type: Reaction
is described by: ECO:0000269
reversible: false
is: SBO:0000176
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.1.3.25
kinetic law: MODEL1310110011#
name: myo-inositol 1-phosphatase
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
reactant: MODEL1310110011#
fast: false

metaM C05279 m
name: trans,cis-Lauro-2,6-dienoyl-CoA
has only substance units: false
is: CHEBI:28387
initial amount: NaN
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
initial concentration: 1.0
is: SBO:0000247
is: HMDB11123
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_2e674d9c_86dc_4647_9d27_8afe29b3db3a
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:111
constant: false
has only substance units: false
initial amount: NaN
name: ADCY5
boundary condition: true
is: O95622
type: Species

metaM dmnoncoa x
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: 4,8 dimethylnonanoyl-CoA
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
is: SBO:0000247
is: HMDB11604
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_2a8cd416_d73e_4dcb_a0d7_83f76441bf54
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: Q14032
type: Species
is encoded by: hsa:570
name: BAAT

metaM glutcoa c
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1
initial amount: NaN
constant: false
is: HMDB01339
is: SBO:0000247
has only substance units: false
name: glutaryl-CoA(5-)
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_cfd1986e_0b40_496b_8d0d_203bc8dd7144
name: SLC22A2
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6582
type: Species
constant: false

metaM dlnlcgcrn c
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: dihomo-gamma-linolenyl carnitine
is: CHEBI:16004
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
type: Species
has only substance units: false
is: HMDB01311
constant: false
initial concentration: 1.0

metaR HDDACBP
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM 3hbcoa m
constant: false
name: (S)-3-hydroxybutanoyl-CoA(4-)
initial concentration: 1.0
initial amount: NaN
is: HMDB01166
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:57316

metaM nrvnc e
initial amount: NaN
name: nervonate
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:32392
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB02368

metaM lnlncgcoa c
is: HMDB06368
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
constant: false
initial amount: NaN
is: CHEBI:57363
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
name: gamma-linolenoyl-CoA(4-)
boundary condition: false

metaM cmp g
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: CHEBI:60377
initial concentration: 1.0
name: CMP(2-)
is: HMDB00095

metaM 3tetd7ecoa m
initial concentration: 1.0
is: HMDB05066
has only substance units: false
name: 3-hydroxy tetradecenoyl-7-coa
initial amount: NaN
constant: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_83e86d77_60b1_44b5_93eb_cc827a96892f
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
constant: false
name: PDE8A
has only substance units: false
is encoded by: hsa:5151

http://identifiers.org/biomodels.db/MODEL1310110011#_8a3caa0a_3a0e_422e_ad5e_fb43a4b06a0d
has only substance units: false
type: Species
constant: false
is: SBO:0000252
name: _AA081045_1_e
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:AA081045

http://identifiers.org/biomodels.db/MODEL1310110011#_e31183eb_d377_44c6_93e5_96771da559f6
constant: false
has only substance units: false
is: SBO:0000297
is encoded by: hsa:5048
type: Species
has part: P43034
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: PAFAH1B1:PAFAH1B2:PAFAH1B3

metaM c5dc e
type: Species
is: SBO:0000247
name: glutaryl carnitine
initial amount: NaN
notes: FORMULA: C12H21NO6 CHARGE: 0
is: HMDB13130
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM HC02208 c
boundary condition: false
constant: false
initial concentration: 1.0
name: prostaglandin-d1
is: CHEBI:27696
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
is: SBO:0000247
initial amount: NaN
type: Species

metaR EX decdicrn
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decadienoyl carnitine
type: Reaction

metaR r2121
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110011#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110011#

metaR r0962
fast: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110011#

metaR VALTAm
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
modifier: MODEL1310110011#
is: SBO:0000176
reactant: MODEL1310110011#
name: valine transaminase, mitochondiral
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110011#
product: MODEL1310110011#

metaR FAOXC164m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_f214a986_dc95_4917_b41f_19491d1c628e
boundary condition: true
name: ST20
type: Species
is: Q9HBF5
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:400410
is: SBO:0000252
initial amount: NaN

metaR C18OHc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecanoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_fbccee10_76e6_4642_bdf3_ea1c3d5a9d37
has only substance units: false
initial amount: NaN
name: SLC25A2
is encoded by: hsa:83884
type: Species
is: SBO:0000252
is: Q9BXI2
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_2fe2eb59_b755_4480_b69d_424f645db8f3
is encoded by: hsa:759
has only substance units: false
type: Species
is: P00915
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: CA1
boundary condition: true

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaR 2OXOADPTm
reactant: MODEL1310110011#
is: SBO:0000185
kinetic law: MODEL1310110011#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
fast: false
product: MODEL1310110011#
modifier: MODEL1310110011#
name: 2-oxoadipate shuttle (cytosol/mitochondria)
is described by: ECO:0000269

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaM ttdca e
is: CHEBI:30807
is: HMDB00806
has only substance units: false
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
initial amount: NaN
type: Species
name: tetradecanoate (n-C14:0)
is: C06424
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR r2122
reversible: true
product: MODEL1310110011#
modifier: MODEL1310110011#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110011#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM c5dc c
is: SBO:0000247
name: glutaryl carnitine
notes: FORMULA: C12H21NO6 CHARGE: 0
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB13130
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_b8bf3003_0582_4437_8319_e3399f27535f
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6560
constant: false
is: SBO:0000252
is: F5H066
boundary condition: true
name: SLC12A4
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_d65e3611_d937_405e_8ccc_29bf25243527
is: Q16720
initial amount: NaN
has only substance units: false
type: Species
name: ATP2B3
constant: false
initial concentration: NaN
is encoded by: hsa:492
is: SBO:0000252
boundary condition: true

metaM 10fthf6glu e
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
is: CHEBI:57454
has only substance units: false
initial concentration: 1.0
is: HMDB00972
boundary condition: false
name: 10-formyltetrahydrofolate-[Glu](6)
type: Species

metaR DECDPtm
is described by: ECO:0000000
type: Reaction
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
product: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:ubiquinone precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is: SBO:0000185
reversible: true

metaM cmp e
name: CMP(2-)
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:60377
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial amount: NaN
is: HMDB00095

metaM co2 e
type: Species
constant: false
name: CO2
initial concentration: 1.0
is: HMDB01967
has only substance units: false
is: CHEBI:16526
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
boundary condition: false
is: SBO:0000247
is: C00011
initial amount: NaN

metaM ksi pre34 g
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
is: C00130
is: HMDB00175
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 34
constant: false
is: CHEBI:58053
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_fc4b60b5_00dd_4b34_bb80_8c168075f5bf
initial concentration: NaN
name: ATP2B1
type: Species
is: P20020
is encoded by: hsa:490
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true

metaM HC02208 e
boundary condition: false
type: Species
name: prostaglandin-d1
is: CHEBI:27696
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false

metaM hexdiac c
name: hexadecanediocacid
constant: false
boundary condition: false
is: HMDB00672
is: C08260
has only substance units: false
initial amount: NaN
notes: FORMULA: C16H28O4 CHARGE: -2
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR r0960
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
reactant: MODEL1310110011#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000185

metaR PRODt2r
reversible: true
name: D-proline reversible transport via proton symport
reactant: MODEL1310110011#
is: SBO:0000185
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
is described by: ECO:0000304
type: Reaction
fast: false

metaM fad m
type: Species
is: CHEBI:16238
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: HMDB01248
has only substance units: false
is: C00016
name: Flavin adenine dinucleotide oxidized
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR S6T5g
modifier: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: false
product: MODEL1310110011#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110011#

metaR GLUTCOADHm
kinetic law: MODEL1310110011#
is described by: ECO:0000304
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.7
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
reversible: false
product: MODEL1310110011#
fast: false
name: glutaryl-CoA dehydrogenase (mitochondria)
reactant: MODEL1310110011#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_b7416037_7cf0_4215_a2bb_bb8ef483c662
is: P25092
name: GUCY2C
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2984
constant: false
is: SBO:0000252

metaM nicrnt n
is: CHEBI:57502
has only substance units: false
notes: FORMULA: C11H12NO9P CHARGE: -2 INCHI: InChI=1S/C11H14NO9P/c13-8-7(5-20-22(17,18)19)21-10(9(8)14)12-3-1-2-6(4-12)11(15)16/h1-4,7-10,13-14H,5H2,(H2-,15,16,17,18,19)/p-2/t7-,8-,9-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB01132
type: Species
initial concentration: 1.0
name: nicotinate D-ribonucleotide(2-)

http://identifiers.org/biomodels.db/MODEL1310110011#_fcbb1f82_6116_4b68_a584_0b4d708fd5b7
is encoded by: hsa:766
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P43166
name: CA7

http://identifiers.org/biomodels.db/MODEL1310110011#_814ab1ca_5fa8_4061_8c8c_24538e2cb2a4
has only substance units: false
is: SBO:0000252
name: COX7C
is: P15954
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1350
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_22e53509_9ff2_4932_aef6_654616441bea
is encoded by: hsa:54872
initial concentration: NaN
is: SBO:0000297
name: PIGF:PIGG
boundary condition: true
constant: false
type: Species
has only substance units: false
has part: Q8NCI4
initial amount: NaN

metaR r2120
modifier: MODEL1310110011#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false

metaM ttdca c
has only substance units: false
name: myristate
is: CHEBI:30807
is: HMDB00806
type: Species
initial amount: NaN
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247

metaR r0321
is described by: ECO:0000000
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
type: Reaction
product: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.5.2
reactant: MODEL1310110011#
reversible: false

metaM c226coa x
boundary condition: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
has only substance units: false
initial amount: NaN
is: C16169
initial concentration: 1.0
name: cervonyl coenzyme A
constant: false
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205479

http://identifiers.org/biomodels.db/MODEL1310110011#_af51b5db_4ff2_4825_9df8_3c90d515b582
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:51
is: SBO:0000252
boundary condition: true
has only substance units: false
is: B4DK61
name: ACOX1
initial amount: NaN

metaR RE3565C
type: Reaction
kinetic law: MODEL1310110011#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
product: MODEL1310110011#
reversible: true
reactant: MODEL1310110011#
fast: false
is described by: ECO:0000000
name: RE3565

metaR PI4PP
reactant: MODEL1310110011#
reversible: false
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110011#
type: Reaction
name: phosphatidylinositol-4-phosphate 4-phosphatase
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2425833 NOTES:NCD
is: SBO:0000176

metaR ACACt2
product: MODEL1310110011#
is described by: ECO:0000269
modifier: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
reversible: true
is: SBO:0000185
reactant: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#
name: acetoacetate transport via proton symport

metaR MI145PP
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.86
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.56
product: MODEL1310110011#
is: SBO:0000176
name: inositol-1,4,5-trisphosphate 5-phosphatase
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.36
reversible: false
type: Reaction
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
reactant: MODEL1310110011#

metaM co2 c
is: CHEBI:3313
name: CO2
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: HMDB01967
notes: FORMULA: CO2 CHARGE: 0
is: C00011
is: SBO:0000247
initial amount: NaN

metaM cmp c
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:60377
boundary condition: false
is: SBO:0000247
is: C00055
initial amount: NaN
is: HMDB00095
name: CMP

http://identifiers.org/biomodels.db/MODEL1310110011#_1556ae8d_af9d_4e18_935b_b57efed74f58
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:R39999
name: _R39999_1_c
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_bc511c64_3fb5_4c5d_b92b_fd3391fe3ddf
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AA854479
name: _AA854479_1_m
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_326036d6_d3d6_461d_998b_8dc666c72606
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:761
initial amount: NaN
is: P07451
boundary condition: true
name: CA3
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_abe15591_ffd1_433c_9567_35f50dde8a33
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:2639
constant: false
name: GCDH
is: Q92947

metaR r2126
modifier: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110011#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185

metaM 4nph e
is: SBO:0000247
type: Species
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
is: CHEBI:57917
has only substance units: false
is: HMDB01232
boundary condition: false
initial amount: NaN
name: 4-nitrophenolate
constant: false
initial concentration: 1.0

metaM HC01522 c
constant: false
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
type: Species
is: CHEBI:28508
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: Gentisate aldehyde
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_f32f0c78_52b7_4456_994a_dd6e70a93a40
is encoded by: hsa:2027
is: P13929
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
name: ENO3

metaM 42A3HP24DB c
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
is: C05645
is: HMDB04083
type: Species
constant: false
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/7956
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaR SPODMe
is version of: http://identifiers.org/ec-code/1.15.1.1
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (6649.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:12126755,PMID:3476950,PMID:9228011 NOTES:JLR
name: superoxide dismutase, extracellular
product: MODEL1310110011#
is: SBO:0000176
fast: false
reversible: false

metaM udpglcur c
is: CHEBI:58052
boundary condition: false
is: SBO:0000247
name: UDP-D-glucuronate
is: C00167
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
initial amount: NaN
is: HMDB00935
initial concentration: 1.0
has only substance units: false
constant: false
type: Species

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaM lnlncacoa c
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
boundary condition: false
is: CHEBI:51985
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
name: alpha-Linolenoyl-CoA
is: HMDB06290

metaR r2125
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110011#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110011#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110011#_6b671020_18f0_471a_89f8_1eb09263b4f3
constant: false
is encoded by: hsa:2026
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: ENO2
type: Species
is: P09104

metaR r2420
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
kinetic law: MODEL1310110011#
fast: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
product: MODEL1310110011#
is: SBO:0000185
reversible: true
reactant: MODEL1310110011#

metaR AG13T3g
is described by: ECO:0000000
type: Reaction
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110011#
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
fast: false
kinetic law: MODEL1310110011#

metaR DECCRNe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydecanoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_884cd433_cd4f_4310_9281_884848f36032
is encoded by: hsa:79369
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is: Q9C0J1
name: B3GNT4

metaR PMTCOAtx
kinetic law: MODEL1310110011#
is: SBO:0000185
name: fatty acid intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110011#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110011#_a5043ab7_9be1_4150_b416_959c7eeb4fd9
is: Q8N9L9
constant: false
name: ACOT4
has only substance units: false
is encoded by: hsa:122970
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

metaR r2124
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110011#
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
product: MODEL1310110011#
modifier: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_29498505_e7e0_4f36_8555_26a06d9c51ba
initial amount: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6240
name: RRM1
is: P23921
is: SBO:0000252

metaM ksi pre27 g
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
initial concentration: 1.0
boundary condition: false
is: CHEBI:58053
initial amount: NaN
is: HMDB00175
constant: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 27
type: Species
is: C00130
has only substance units: false

metaR GLYSARCNc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Hydrolysis of glycylsarcosine for uptake
type: Reaction

metaM ocdececrn m
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C25H47NO4 CHARGE: 0
name: 11-octadecenoyl carnitine
type: Species
initial concentration: 1.0
is: HMDB06351

http://identifiers.org/biomodels.db/MODEL1310110011#_a1df4aab_c556_4735_bfb2_95167d60e5bd
name: ACAA1
is: SBO:0000252
constant: false
has only substance units: false
type: Species
boundary condition: true
is: Q96CA6
is encoded by: hsa:30
initial concentration: NaN
initial amount: NaN

metaM cmp n
is: HMDB00095
has only substance units: false
initial amount: NaN
boundary condition: false
name: CMP(2-)
is: CHEBI:60377
initial concentration: 1.0
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_56647c41_975c_422f_8cac_76d345947c47
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:PRO1933
is: SBO:0000252
constant: false
name: _PRO1933_1_m

http://identifiers.org/biomodels.db/MODEL1310110011#_d84b3321_85d4_4e97_8ef2_1e4327f9a56e
has only substance units: false
name: UCK1
is encoded by: hsa:83549
boundary condition: true
initial amount: NaN
is: Q5JT09
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species

metaR r2123
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110011#
is: SBO:0000185
fast: false
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110011#
reversible: true

metaM lnlccrn c
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: Linoleyl carnitine
constant: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB06469

http://identifiers.org/biomodels.db/MODEL1310110011#_650b31f2_2b08_46b5_bd87_806794365653
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:230
type: Species
is: SBO:0000252
constant: false
name: ALDOC
has only substance units: false
boundary condition: true
is: P09972

http://identifiers.org/biomodels.db/MODEL1310110011#_43e46d70_8eab_4f9d_b9d2_03e25bee5f61
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:5831
is: A6NFM2
name: PYCR1
type: Species
is: SBO:0000252

metaM 4hpro LT m
is: CHEBI:18095
boundary condition: false
name: trans-4-hydroxy-L-proline
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00725
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690

metaM glutcoa m
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
boundary condition: false
type: Species
is: HMDB01339
name: glutaryl-CoA(5-)
is: CHEBI:57378

metaM co2 m
type: Species
initial concentration: 1.0
is: HMDB01967
name: CO2
is: CHEBI:16526
constant: false
has only substance units: false
initial amount: NaN
is: C00011
is: SBO:0000247
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
boundary condition: false

metaM hdd2crn c
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
initial concentration: 1.0
initial amount: NaN
is: HMDB06317
boundary condition: false
name: trans-Hexadec-2-enoyl carnitine
constant: false
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_cd276fe4_a125_4dfa_a5ce_a7637f0baa9d
is: Q9Y4C5
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:9435
has only substance units: false
constant: false
name: CHST2
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_9d95934c_a335_4f8f_be3a_487aef9c2a85
has only substance units: false
constant: false
is: Q9H6Y6
initial concentration: NaN
name: MYO5B
boundary condition: true
is encoded by: hsa:4645
type: Species
is: SBO:0000252
initial amount: NaN

metaR RE0944E
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110011#
name: RE0944
is version of: http://identifiers.org/ec-code/3.2.1.17
reactant: MODEL1310110011#
reversible: true
fast: false
product: MODEL1310110011#
modifier: MODEL1310110011#

metaR RE3381E
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290,PMID:10690708,PMID:11087858,PMID:11818531 NOTES:
product: MODEL1310110011#
type: Reaction
fast: false
modifier: MODEL1310110011#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110011#
name: RE3381
is version of: http://identifiers.org/ec-code/3.2.1.31
kinetic law: MODEL1310110011#
is: SBO:0000176

metaR r2129
modifier: MODEL1310110011#
product: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_7e172a5c_2e75_4776_aa01_75a164eeb271
is encoded by: hsa:4723
constant: false
is: E5KNH5
has only substance units: false
initial concentration: NaN
name: NDUFV1
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN

metaM hdcoa c
type: Species
is: HMDB06532
constant: false
initial concentration: 1.0
initial amount: NaN
name: Hexadecenoyl-CoA (n-C16:1CoA)
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C37H60N7O17P3S CHARGE: -4

metaM ksi pre3 g
constant: false
is: CHEBI:58053
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 3
notes: FORMULA: C93H152N6O67X CHARGE: -1
initial concentration: 1.0
is: HMDB00175
type: Species
is: C00130

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaR EX glygn4 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaR r0317
reactant: MODEL1310110011#
fast: false
modifier: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
kinetic law: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.1.2.10
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4

metaR r2128
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110011#
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_b4548b2c_c839_4982_866c_8dfec5bd4f8b
is encoded by: hsa:55753
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: Q9ULD0
name: OGDHL
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_555c5fe8_097d_4fdb_ba57_9599a2fbb5da
is: Q9BRB3
is encoded by: hsa:9091
name: PIGQ
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
constant: false

metaR TPI
name: triose-phosphate isomerase
is: SBO:0000176
product: MODEL1310110011#
is described by: ECO:0000134
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/5.3.1.1
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
reversible: true
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_7f25c219_9f0d_4e8f_a950_e933c3f4851a
has only substance units: false
boundary condition: true
constant: false
is: Q59F77
type: Species
initial concentration: NaN
name: PLCB2
is encoded by: hsa:5330
initial amount: NaN
is: SBO:0000252

metaM cbasp c
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
initial amount: NaN
boundary condition: false
name: N-Carbamoyl-L-aspartate
is: CHEBI:32814
is: HMDB00828
has only substance units: false
type: Species
is: C00438
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM 5oxpro e
name: 5-oxoprolinate
is: SBO:0000247
boundary condition: false
type: Species
constant: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
is: CHEBI:57606
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00267

metaR C181CPT2
fast: false
is: SBO:0000176
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV
reversible: false
name: transport of Octadecenoyl-CoA into mitochondrial matrix

http://identifiers.org/biomodels.db/MODEL1310110011#_92e2642d_b849_49a1_8123_0af23ec67a01
initial amount: NaN
constant: false
has only substance units: false
name: _AV727634_1_c
is: SBO:0000252
is encoded by: hsa:AV727634
type: Species
boundary condition: true
initial concentration: NaN

metaR RE0691C
product: MODEL1310110011#
name: RE0691
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
fast: false
kinetic law: MODEL1310110011#
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110011#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110011#_2d1839e8_3d26_4e02_ab82_2f70e94f9c3d
is: Q9H310
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:57127
is: SBO:0000252
type: Species
name: RHBG
initial amount: NaN
boundary condition: true

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

metaR r2127
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110011#

metaR CRNtx
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
reactant: MODEL1310110011#
name: carnitine transport peroxisome to mitochondria
is: SBO:0000185
product: MODEL1310110011#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110011#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_9af84cba_bba1_4916_8e7b_bcbee5d706c9
constant: false
name: CHAT
is encoded by: hsa:1103
is: SBO:0000252
type: Species
initial amount: NaN
is: D3DX95
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM CE1617 r
is: HMDB01358
is: CHEBI:17898
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
name: 9-cis-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8-,16-14+ EHMN_ABBREVIATION: CE1617
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_8755d9af_068f_4b13_8fb5_32263698aee4
has only substance units: false
name: CA12
constant: false
is encoded by: hsa:771
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM dcsptn1crn c
constant: false
is: SBO:0000247
is: HMDB06321
type: Species
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoyl carnitine
initial amount: NaN

metaM 2octdectecoa m
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 2,6,9,12-octadecatetraenoylcoa
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
has only substance units: false
is: HMDB06294
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_b51e8fd5_6aec_4091_a870_df47ef7af9c8
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:645
has only substance units: false
type: Species
boundary condition: true
is: P30043
name: BLVRB
constant: false
initial concentration: NaN

metaR C181CPT1
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
name: transport of Octadecenoyl-CoA into mitochondrial matrix
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110011#
is: SBO:0000176
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110011#

metaM c101crn c
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: decenoyl carnitine
initial concentration: 1.0
constant: false
notes: FORMULA: C17H31NO4 CHARGE: 0
is: HMDB13205
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_7b2d43d2_ab25_4796_ba92_41162cee7c9a
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: B3KUK6
boundary condition: true
is encoded by: hsa:93034
constant: false
name: NT5C1B
has only substance units: false
type: Species

metaM CE5853 e
initial concentration: 1.0
has only substance units: false
name: alpha-CEHC-glucuronide
type: Species
constant: false
is: CHEBI:12947
initial amount: NaN
notes: FORMULA: C22H29O10 CHARGE: -1 INCHI: InChI=1/C22H30O10/c1-9-10(2)18-12(11(3)14(9)24)5-7-22(4,32-18)8-6-13(23)30-21-17(27)15(25)16(26)19(31-21)20(28)29/h15-17,19,21,24-27H,5-8H2,1-4H3,(H,28,29)/p-1/t15-,16+,17-,19-,21+,22?/m1/s1 EHMN_ABBREVIATION: CE5853
is: SBO:0000247
boundary condition: false

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_c1aeab89_8531_472b_b3d5_08078a9fd5e0
constant: false
is: SBO:0000252
initial amount: NaN
name: CROT
boundary condition: true
is: E7EQF2
initial concentration: NaN
type: Species
is encoded by: hsa:54677
has only substance units: false

metaR PAIL45P HStn
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110011#
fast: false
reversible: true
reactant: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)

metaM 5oxpro c
has only substance units: false
boundary condition: false
is: SBO:0000247
name: 5-oxoprolinate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
is: HMDB00267
is: CHEBI:57606
constant: false
type: Species

metaR r0545
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000176
modifier: MODEL1310110011#
is described by: ECO:0000000
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
type: Reaction
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39

http://identifiers.org/biomodels.db/MODEL1310110011#_896da32d_2b12_47fe_b31a_83d793e55639
has only substance units: false
type: Species
is: G3XA95
name: PPAP2A
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8611

metaR DCSPTN1CRNt
is described by: ECO:0000269
kinetic law: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110011#
type: Reaction
reversible: false
modifier: MODEL1310110011#
product: MODEL1310110011#
name: transport into the mitochondria (carnitine)
fast: false

metaM dump n
is: CHEBI:246422
constant: false
name: dUMP(2-)
is: HMDB01409
initial amount: NaN
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0

metaR NDPK9
type: Reaction
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:IDP)
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
reactant: MODEL1310110011#
is: SBO:0000176
product: MODEL1310110011#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_8de3d5ac_839b_4b15_96e9_eaf2344084f0
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:83715
initial amount: NaN
is: B1AK53
constant: false
is: SBO:0000252
name: ESPN

http://identifiers.org/biomodels.db/MODEL1310110011#_d9d26a2d_8979_4acc_89c4_5d743fa73787
is encoded by: hsa:386757
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
name: SLC6A10P
boundary condition: true
initial amount: NaN

metaM ksii core2 pre8 g
constant: false
is: C00130
name: keratan sulfate II biosynthesis, precursor 8
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00175
type: Species
is: SBO:0000247
is: CHEBI:58053
notes: FORMULA: C75H121N6O56SX CHARGE: -2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_9a4eca66_8cd2_4688_802b_c26efdb68f0b
name: PLCE1
is: Q9P212
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:51196
initial amount: NaN

metaR FACOAL240
fast: false
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110011#
type: Reaction
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
is: SBO:0000176
kinetic law: MODEL1310110011#

metaM co2 x
boundary condition: false
is: SBO:0000247
is: HMDB01967
initial concentration: 1.0
has only substance units: false
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
type: Species
constant: false
name: carbon dioxide
is: CHEBI:16526
initial amount: NaN

metaM forglu c
initial concentration: 1.0
name: N-Formimidoyl-L-glutamate
is: HMDB00854
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
boundary condition: false
initial amount: NaN
constant: false
is: C00439
is: SBO:0000247
is: CHEBI:18327
type: Species
has only substance units: false

metaM 3dpdhb me m
initial amount: NaN
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C58H87O4 CHARGE: -1 INCHI: InChI=1S/C58H88O4/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58(60)61)43-56(62-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43,59H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3,(H,60,61)/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
is: SBO:0000247
constant: false
is: CHEBI:50776
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_62bae357_9c7b_4349_a023_192250f776ef
name: SI
is: P14410
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:6476
has only substance units: false
boundary condition: true

metaR THRSERNaEx
reactant: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
is: SBO:0000185
name: L-serine/L-threonine Na-dependent exchange (Thr-L in)
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110011#
product: MODEL1310110011#
fast: false

metaM c101crn e
has only substance units: false
constant: false
name: decenoyl carnitine
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB13205
notes: FORMULA: C17H31NO4 CHARGE: 0

metaR HESTRATRIOLtr
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be transported out of the cell NJ
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
product: MODEL1310110011#
reversible: true
name: hydroxylated estrogen derivative transport
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaM dump m
is: SBO:0000247
has only substance units: false
type: Species
name: dUMP(2-)
is: CHEBI:246422
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB01409
initial amount: NaN

metaR INSTt4
modifier: MODEL1310110011#
name: inositol transport via sodium symport
kinetic law: MODEL1310110011#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000185
fast: false
product: MODEL1310110011#
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_193ba864_a2aa_49a6_beb7_6bc7716917c2
is: SBO:0000252
is encoded by: hsa:8574
name: AKR7A2
initial concentration: NaN
is: O43488
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true

metaM sebacid c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00792
notes: FORMULA: C10H16O4 CHARGE: -2
constant: false
initial amount: NaN
name: sebacicacid
is: C08277
type: Species
has only substance units: false

metaR EX thf LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange
type: Reaction

metaM hdd2crn m
has only substance units: false
name: trans-Hexadec-2-enoyl carnitine
initial concentration: 1.0
boundary condition: false
is: HMDB06317
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+

http://identifiers.org/biomodels.db/MODEL1310110011#_8e074088_49d3_4954_b8ee_a22bf1dc72b1
is: SBO:0000252
has only substance units: false
type: Species
constant: false
boundary condition: true
is encoded by: hsa:AI191472
name: _AI191472_1_c
initial amount: NaN
initial concentration: NaN

metaR UMPK7n
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110011#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110011#
fast: false
is: SBO:0000176
type: Reaction
name: UMP kinase (dGTP),nuclear
modifier: MODEL1310110011#
product: MODEL1310110011#

metaR 10FTHFtm
product: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110011#_4e8bd03b_d985_480b_b41f_7ed1ff7e13ef
constant: false
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:65263
is: SBO:0000252
initial concentration: NaN
name: PYCRL
boundary condition: true
is: Q53H96

metaR RE2659R
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reversible: true
name: RE2659
product: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110011#
is: SBO:0000176
reactant: MODEL1310110011#
fast: false

metaR SQLSr
reversible: false
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.5.1.21
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
is described by: ECO:0000134
product: MODEL1310110011#
modifier: MODEL1310110011#
fast: false
is: SBO:0000176
type: Reaction
name: Squalene synthase

metaR NDPK7
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dCDP)
reversible: true
kinetic law: MODEL1310110011#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110011#_457f3c50_5fd2_4b2b_bcf7_3e15c8cb5e65
initial amount: NaN
is encoded by: hsa:501
type: Species
is: SBO:0000252
name: ALDH7A1
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is: E7EPT3

metaM tetpent6coa x
has only substance units: false
is: C16172
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
name: tetracosapentaenoyl coenzyme A, n-6
initial concentration: 1.0
boundary condition: false

metaR PPNCL3
is described by: ECO:0000269
kinetic law: MODEL1310110011#
type: Reaction
fast: false
modifier: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000176
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/6.3.2.5
name: phosphopantothenate-cysteine ligase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110011#_25221421_7459_4f27_9278_8887b8895544
is encoded by: hsa:7498
name: XDH
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
is: P47989

metaM elaidcrn m
has only substance units: false
constant: false
is: HMDB06464
initial concentration: 1.0
is: SBO:0000247
name: Elaidic carnitine
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+

http://identifiers.org/biomodels.db/MODEL1310110011#_f944817a_8ad2_4ef0_b583_f8f258bf4a4c
initial concentration: NaN
has only substance units: false
is: P35219
constant: false
is: SBO:0000252
name: CA8
is encoded by: hsa:767
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_6d961141_1330_4378_929e_3561ee744fc7
boundary condition: true
has only substance units: false
name: _AI684467_1_m
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI684467

metaM CE5118 m
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
is: SBO:0000247
has only substance units: false
is: CHEBI:12947
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA

metaM hdcoa m
has only substance units: false
name: Hexadecenoyl-CoA (n-C16:1CoA)
is: HMDB06532
constant: false
initial concentration: 1.0
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN

metaR NDPK8
name: Nucleoside-diphosphate kinase (ATP:dADP)
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
type: Reaction
product: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110011#_0e7a5798_6a23_473a_ac51_1354996666ce
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:154091
constant: false
is: Q8TD20
initial concentration: NaN
name: SLC2A12

http://identifiers.org/biomodels.db/MODEL1310110011#_9b31c61a_604d_4e5d_8491_574d46ab1d66
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: true
name: LYZL1
is: SBO:0000252
initial concentration: NaN
is: Q6UWQ5
is encoded by: hsa:84569

metaR NDPK4
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110011#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
product: MODEL1310110011#
modifier: MODEL1310110011#
reversible: true
name: nucleoside-diphosphate kinase (ATP:dTDP)
kinetic law: MODEL1310110011#

metaR r0549
is version of: http://identifiers.org/ec-code/6.1.1.17
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
reversible: true
reactant: MODEL1310110011#
is: SBO:0000176
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.6.5.3
type: Reaction
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.6.99.3
fast: false
kinetic law: MODEL1310110011#

metaR SUCCACT
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of succinate
type: Reaction

metaR r2425
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: false
reactant: MODEL1310110011#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.16.1

metaM lald L c
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
initial amount: NaN
name: (S)-lactaldehyde
type: Species
is: HMDB03052
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:18041

http://identifiers.org/biomodels.db/MODEL1310110011#_64891ed5_893a_4cd9_b8bb_68ae8d19cc06
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
name: PIGN
constant: false
is: O95427
is encoded by: hsa:23556
initial concentration: NaN
initial amount: NaN

metaR NDPK5
type: Reaction
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110011#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
fast: false
product: MODEL1310110011#
name: Nucleoside-diphosphate kinase (ATP:dGDP)

metaR NDPK6
kinetic law: MODEL1310110011#
name: Nucleoside-diphosphate kinase (ATP:dUDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110011#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110011#
is: SBO:0000176

metaM ocdececrn c
boundary condition: false
has only substance units: false
name: 11-octadecenoyl carnitine
constant: false
is: HMDB06351
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C25H47NO4 CHARGE: 0

metaM dcsptn1crn m
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB06321
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: docosa-4,7,10,13,16-pentaenoyl carnitine
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
constant: false

metaM em2emgacpail hs r
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:16038
has only substance units: false
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
initial amount: NaN

metaR RDH2a
is version of: http://identifiers.org/ec-code/1.1.1.300
type: Reaction
is: SBO:0000176
product: MODEL1310110011#
reversible: true
name: retinol dehydrogenase (9-cis,NADPH)
is version of: http://identifiers.org/ec-code/1.1.1.105
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is described by: ECO:0000269
reactant: MODEL1310110011#
fast: false

metaR MTHFR3
is: SBO:0000176
is described by: ECO:0000134
reversible: false
type: Reaction
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (4524.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 2 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 350. NOTES:absorbed folate undergoes conversion to 5-methyl-THF within the enterocytes.
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.20
name: 5,10-methylenetetrahydrofolatereductase (NADPH)
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_f6bd1efd_5b7c_495e_894a_8aa40af38588
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q11201
constant: false
is encoded by: hsa:6482
has only substance units: false
name: ST3GAL1

metaR FACOAL241
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
is: SBO:0000176
fast: false
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110011#
type: Reaction
reversible: true

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaM HC01403 m
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:28325
name: (S)-Hydroxydecanoyl-CoA

metaR NDPK2
name: nucleoside-diphosphate kinase (ATP:UDP)
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
reactant: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
product: MODEL1310110011#
fast: false
reversible: true
kinetic law: MODEL1310110011#

metaR FUMSO4tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: true
product: MODEL1310110011#
modifier: MODEL1310110011#
fast: false
type: Reaction
name: Fumarate:sulfate antiport, mitochondrial
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_c5b1a8d1_1a51_432c_a5e6_d8568fbcf87e
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: VNN1
is encoded by: hsa:8876
is: SBO:0000252
has only substance units: false
constant: false
is: O95497
type: Species

metaR ENO
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/4.2.1.11
fast: false
reactant: MODEL1310110011#
reversible: true
kinetic law: MODEL1310110011#
name: enolase
notes: GENE_ASSOCIATION: (2023.1) or (2027.2) or (2027.1) or (2026.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.2.1.11 Confidence Level: 0 AUTHORS: PMID:5939,PMID:6626557 NOTES:SMP
is: SBO:0000176
modifier: MODEL1310110011#
is described by: ECO:0000134
type: Reaction

metaM rib D c
is: CHEBI:16988
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00283
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
has only substance units: false
type: Species
constant: false
name: D-ribose
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_ea9f6c22_a092_4db5_85c2_8ab85afd77a3
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:28231
boundary condition: true
is: Q96BD0
constant: false
name: SLCO4A1
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_1bf7a6c8_a0bf_4068_a19a_059b357ce01a
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
name: _R51273_1_c
initial concentration: NaN
constant: false
is encoded by: hsa:R51273
type: Species

metaR SO4t4 2
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
reversible: true
name: sulfate transport via sodium symport
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000269

metaR FUMTSULtm
is: SBO:0000185
modifier: MODEL1310110011#
name: Fumarate:thiosulfate antiport, mitochondrial
type: Reaction
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reactant: MODEL1310110011#
is described by: ECO:0000269

metaR r0547
fast: false
name: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
reversible: true
product: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000176
modifier: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.1.4

metaM acnam c
name: N-acetylneuraminate
is: CHEBI:35418
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
constant: false
type: Species
is: HMDB00230
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_1d9d6424_0b34_4e65_99de_8d69fd02a613
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:158
is: SBO:0000252
boundary condition: true
name: ADSL

metaM lnlncacoa m
name: alpha-Linolenoyl-CoA
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
is: CHEBI:51985
is: HMDB06290
type: Species
has only substance units: false

metaR NDPK3
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110011#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
reactant: MODEL1310110011#
product: MODEL1310110011#
fast: false
name: nucleoside-diphosphate kinase (ATP:CDP)
is: SBO:0000176
kinetic law: MODEL1310110011#

metaM c12dccoa x
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
initial concentration: 1.0
boundary condition: false
type: Species
name: dodecanedioylcoa
is: HMDB03712
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_bddec997_2efd_4daa_b2fc_df396fc366d7
boundary condition: true
name: PSAT1
constant: false
is encoded by: hsa:29968
type: Species
is: Q9Y617
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM glyc m
type: Species
is: HMDB00131
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:17754
boundary condition: false
has only substance units: false
name: Glycerol
initial concentration: 1.0
is: C00116
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116

metaR H2CO3D
fast: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reversible: true
modifier: MODEL1310110011#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
type: Reaction
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/4.2.1.1
name: carboxylic acid dissociation

http://identifiers.org/biomodels.db/MODEL1310110011#_e262599e_47d8_43bb_9002_37ce66cfe118
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: INPP5D
is encoded by: hsa:3635
is: Q92835
type: Species
constant: false
has only substance units: false

metaM co2 r
has only substance units: false
type: Species
is: C00011
initial amount: NaN
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: HMDB01967
is: CHEBI:16526
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: CO2

metaM n2m2masn g
initial concentration: 1.0
boundary condition: false
is: C11530
type: Species
notes: FORMULA: C50H83N4O35X CHARGE: 0
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)

http://identifiers.org/biomodels.db/MODEL1310110011#_5485a728_7d68_4fe7_ab25_76772741dff7
is: SBO:0000252
is encoded by: hsa:7296
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
name: TXNRD1
initial concentration: NaN

metaM bglc e
constant: false
notes: FORMULA: C1200000H2200000O1100000 CHARGE: 0
initial concentration: 1.0
type: Species
is: HMDB00893
is: SBO:0000247
name: beta-glucans
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_98d5cf28_ebb5_4f6d_87ca_83a2bde0d8d5
name: FOLR1
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2348
is: P15328
initial concentration: NaN

metaR AG13T15g
modifier: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110011#_dea2c396_e9a1_4bfc_bc5b_b8cc3d1b3f2c
initial concentration: NaN
name: _AI539321_1_c
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI539321

metaM arach c
boundary condition: false
is: CHEBI:32360
type: Species
name: arachidate
initial concentration: 1.0
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
has only substance units: false
is: HMDB02212
constant: false
is: SBO:0000247
initial amount: NaN

metaR RE1527M
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
product: MODEL1310110011#
name: RE1527
reversible: true
reactant: MODEL1310110011#
modifier: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_f5b9f58d_af6d_4fef_827d_9e30abf34ac5
initial amount: NaN
is encoded by: hsa:23305
has only substance units: false
constant: false
type: Species
is: B2RB13
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: ACSL6

http://identifiers.org/biomodels.db/MODEL1310110011#_b10aa16f_4bfc_42bb_894e_33ced0572940
type: Species
is encoded by: hsa:FLJ44968
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: _FLJ44968_1_m
constant: false

metaM c101coa c
is: C14143
is: HMDB04047
constant: false
has only substance units: false
boundary condition: false
name: decenoylcoa
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4

metaM amet c
is: HMDB01185
initial concentration: 1.0
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: CHEBI:15414
boundary condition: false
constant: false
is: SBO:0000247
is: C00019
name: S-Adenosyl-L-methionine
initial amount: NaN
type: Species
has only substance units: false

metaM arachcrn m
boundary condition: false
initial amount: NaN
name: arachidyl carnitine
is: HMDB06460
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
type: Species
constant: false
is: SBO:0000247

metaM nm4masn g
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: C05882
is: SBO:0000247
type: Species
notes: FORMULA: C54H90N3O40X CHARGE: 0

metaR GLYCTO1p
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.3.15
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
name: Glycolate oxidase, peroxisome
modifier: MODEL1310110011#
type: Reaction
is: SBO:0000176
fast: false
reversible: false
is described by: ECO:0000269

metaR P45027A1m
fast: false
kinetic law: MODEL1310110011#
reversible: false
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000269
name: Cytochrome P450 27
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110011#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_dc71253c_af22_4efd_9b1f_c6568e11cd83
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
name: _AI824319_1_r
type: Species
is encoded by: hsa:AI824319
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_90f54d95_2cff_442c_87ba_cde3275ec712
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
constant: false
is: Q6FGQ4
is encoded by: hsa:5538
has only substance units: false
initial amount: NaN
name: PPT1

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_594f2411_9ea6_4302_845a_4e6f7dc17f9f
has only substance units: false
boundary condition: true
name: _AV717590_1_m
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:AV717590
initial amount: NaN
is: SBO:0000252

metaM hco3 e
name: Bicarbonate
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:17544
is: HMDB00595
type: Species
has only substance units: false
is: C00288
constant: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288

metaR MALTe
reversible: false
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (8972.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:3143729 NOTES:IF
fast: false
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction
is described by: ECO:0000269
name: alpha-glucosidase, extracellular
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.2.1.20
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110011#_5c7c0ad8_5d07_44ee_af71_35d16611498c
is: Q02218
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4967
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species
name: OGDH

metaR EX c3dc
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for malonyl carnitine
type: Reaction

metaR RE1901R
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799,PMID:11279029 NOTES:
name: RE1901
is: SBO:0000176
reactant: MODEL1310110011#
fast: false
reversible: true
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000000

metaR ALAtN1
kinetic law: MODEL1310110011#
name: Alanine transport (Na, H coupled)
is: SBO:0000185
reactant: MODEL1310110011#
is described by: ECO:0000269
type: Reaction
reversible: true
modifier: MODEL1310110011#
product: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827

metaR EX gltcho LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for beta glucan-taurocholic acid complex
type: Reaction

metaM arach e
constant: false
is: SBO:0000247
is: CHEBI:32360
has only substance units: false
is: HMDB02212
boundary condition: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
type: Species
initial amount: NaN
initial concentration: 1.0
name: arachidate

metaR r0559
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
kinetic law: MODEL1310110011#
type: Reaction
is: SBO:0000176
product: MODEL1310110011#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110011#
modifier: MODEL1310110011#
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false

metaR G16MT L
reversible: false
is: SBO:0000176
name: Glycolipid 1,6-alpha-D-mannosyltransferase (liver)
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:

metaR M16NTg
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.4.1.143
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
type: Reaction
reversible: false
reactant: MODEL1310110011#
modifier: MODEL1310110011#

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaM o2 e
has only substance units: false
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
is: C00007
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
name: O2
is: CHEBI:15379
is: HMDB01377

http://identifiers.org/biomodels.db/MODEL1310110011#_432b84f1_8404_46e9_9eb6_82bc6bb3bfa7
name: CHAT
has only substance units: false
is encoded by: hsa:1103
constant: false
initial concentration: NaN
type: Species
is: P28329
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

metaM retinal cis 9 c
is: CHEBI:17898
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
has only substance units: false
type: Species
name: all-trans-retinal
is: HMDB01358

metaM adrncrn c
has only substance units: false
type: Species
is: C00318
is: HMDB00062
initial amount: NaN
name: Adrenyl carnitine
initial concentration: 1.0
is: CHEBI:16347
notes: FORMULA: C29H49NO4 CHARGE: 0
constant: false
is: SBO:0000247
boundary condition: false

metaM CE5162 r
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: trans,cis-2,9-octadecadienoyl-CoA
boundary condition: false
is: SBO:0000247
is: CHEBI:12947
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_14bce732_0d00_4848_8630_9de878ac4ab8
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
is: B2RBR4
has only substance units: false
name: SLC20A2
initial amount: NaN
is encoded by: hsa:6575

http://identifiers.org/biomodels.db/MODEL1310110011#_a7526786_09e7_41a3_b73c_1b9e7db94920
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is: P00374
boundary condition: true
name: DHFR
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1719

http://identifiers.org/biomodels.db/MODEL1310110011#_1ac54250_ea2f_45b6_bd11_99245c57f9a8
is: SBO:0000252
is: Q8NFW8
is encoded by: hsa:55907
constant: false
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: CMAS
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_751ea4d4_f0f5_44b3_b96e_460235460500
boundary condition: true
is: SBO:0000252
is encoded by: hsa:MBOAT5
type: Species
constant: false
initial concentration: NaN
name: _MBOAT5_1_c
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_92a4fdce_2464_41c2_83dc_75c6cdba7159
boundary condition: true
initial concentration: NaN
constant: false
name: ALDOA
has only substance units: false
is encoded by: hsa:226
type: Species
is: SBO:0000252
initial amount: NaN

metaR r0558
is: SBO:0000176
reactant: MODEL1310110011#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.5.1.3
product: MODEL1310110011#
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
type: Reaction

metaR KYNATESYN
type: Reaction
kinetic law: MODEL1310110011#
reversible: false
reactant: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
is described by: ECO:0000000
product: MODEL1310110011#
is: SBO:0000176
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase

metaR PRISTCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
fast: false
kinetic law: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110011#
reversible: true
reactant: MODEL1310110011#
is: SBO:0000185
name: pristcoa peroxisomal transport

metaM ppcoa m
is: HMDB01275
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:57392
is: C00100
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
type: Species
initial concentration: 1.0
constant: false
name: Propanoyl-CoA

metaR URATEt
fast: false
name: urate export from cytosol
type: Reaction
reactant: MODEL1310110011#
is: SBO:0000185
product: MODEL1310110011#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaR GLYPHEPEPT1tc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycylphenylalanine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR r1968
reactant: MODEL1310110011#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000185
reversible: false
fast: false
modifier: MODEL1310110011#
type: Reaction

metaR C226CPT2
modifier: MODEL1310110011#
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110011#
name: C226 transport into the mitochondria
product: MODEL1310110011#
is: SBO:0000176
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction

metaR UMPK3n
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000176
name: UMP kinase (UTP),nuclear
is described by: ECO:0000269
reactant: MODEL1310110011#
modifier: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction

metaR PItg
kinetic law: MODEL1310110011#
name: phosphate transport, Golgi apparatus
is described by: ECO:0000000
product: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
is: SBO:0000185
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110011#_1bc77d44_c3e8_4b8b_a045_ec8949e870fb
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:6568
is: Q14916
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: SLC17A1

http://identifiers.org/biomodels.db/MODEL1310110011#_05f144e0_0514_42d6_a699_f4683f0a8e98
has only substance units: false
is: SBO:0000252
boundary condition: true
name: PIGL
initial amount: NaN
is: Q9Y2B2
is encoded by: hsa:9487
constant: false
type: Species
initial concentration: NaN

metaR r0557
fast: false
kinetic law: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:9620315 NOTES:
name: Glutaryl-CoA:dihydrolipoamide S-succinyltransferase Lysine degradation EC:2.3.1.61
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110011#
modifier: MODEL1310110011#
reversible: false
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_dcfe00df_2035_413c_9029_0cf9a33cf31b
boundary condition: true
type: Species
initial concentration: NaN
is: Q9P109
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: GCNT4
is encoded by: hsa:51301

http://identifiers.org/biomodels.db/MODEL1310110011#_5a34feed_2a83_44cb_ab21_c9d23b0737c7
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q9NUB1
constant: false
is encoded by: hsa:84532
has only substance units: false
name: ACSS1

metaR GLYtm
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110011#
reactant: MODEL1310110011#
reversible: true
type: Reaction
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
name: glycine passive transport to mitochondria

http://identifiers.org/biomodels.db/MODEL1310110011#_58253f80_0b1b_47a1_80e1_e519a4b049c5
initial amount: NaN
name: RRM2B
initial concentration: NaN
boundary condition: true
type: Species
is: Q7LG56
has only substance units: false
is encoded by: hsa:50484
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_3574ed03_a224_4a75_aaab_0c42113eb67a
name: FUT8
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2530
type: Species
initial amount: NaN
is: G3V5N0
constant: false
has only substance units: false
is: SBO:0000252

metaM o2 c
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:15379
boundary condition: false
name: O2
is: HMDB01377
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_f6258394_1392_4df6_bc8f_da52f5834668
name: GOT1
initial amount: NaN
has only substance units: false
is: P17174
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:2805
boundary condition: true
initial concentration: NaN

metaR r2079
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110011#
is: SBO:0000185
kinetic law: MODEL1310110011#
product: MODEL1310110011#
modifier: MODEL1310110011#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaR C226CPT1
modifier: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
product: MODEL1310110011#
name: carnitine C22:6 transferase
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
reversible: false
is: SBO:0000176

metaR EX 3deccrn
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydecanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_313af913_0fdd_432a_be3e_bc085cd6d0c7
boundary condition: true
has only substance units: false
name: MTHFR
initial concentration: NaN
is encoded by: hsa:4524
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is: Q59GJ6

metaM dcsptn1coa m
is: C16173
initial concentration: 1.0
constant: false
initial amount: NaN
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB06513
is: http://identifiers.org/pubchem.compound/47205483

metaM C05965 e
boundary condition: false
has only substance units: false
initial amount: NaN
name: 12(S)-HPETE(1-)
is: SBO:0000247
is: CHEBI:57444
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
is: HMDB04243
initial concentration: 1.0
constant: false

metaR r0556
modifier: MODEL1310110011#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
reversible: true
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.14.19.1
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
reactant: MODEL1310110011#
fast: false

metaR RE2269E
kinetic law: MODEL1310110011#
type: Reaction
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
name: RE2269
reactant: MODEL1310110011#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
modifier: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/3.4.21.39

metaR GLYtp
type: Reaction
reversible: true
kinetic law: MODEL1310110011#
fast: false
is: SBO:0000185
reactant: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
name: glycine passive transport to peroxisome

http://identifiers.org/biomodels.db/MODEL1310110011#_4526faeb_fccd_460b_b92d_f30d81f0841a
name: _AV713053_1_m
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
is encoded by: hsa:AV713053
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_208038d2_287f_43d1_a767_699223791e0c
has only substance units: false
is: Q14542
boundary condition: true
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:3177
is: SBO:0000252
name: SLC29A2

http://identifiers.org/biomodels.db/MODEL1310110011#_13a5dcd3_efa6_47a2_b7a3_ea0f16b1b0fc
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5238
is: B4DX94
boundary condition: true
type: Species
initial concentration: NaN
name: PGM3

metaR ACGAMtly
reactant: MODEL1310110011#
name: N-acetyl-glucosamine lysosomal efflux
product: MODEL1310110011#
is: SBO:0000185
kinetic law: MODEL1310110011#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_878ffdec_e5b5_4ef3_926f_6a6b9f2d8140
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: SLC8A3
is encoded by: hsa:6547
type: Species

metaR METS
type: Reaction
name: methionine synthase
is version of: http://identifiers.org/ec-code/2.1.1.13
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (4548.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.1.1.13 Confidence Level: 4 AUTHORS: PMID:8968736,PMID:9013615 NOTES:Human Y/N: Y
product: MODEL1310110011#
is described by: ECO:0000134
modifier: MODEL1310110011#
fast: false
is: SBO:0000176
reversible: false

metaR PHCHGSm
fast: false
kinetic law: MODEL1310110011#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
is described by: ECO:0000000
type: Reaction
product: MODEL1310110011#
reactant: MODEL1310110011#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD

metaR r0295
modifier: MODEL1310110011#
type: Reaction
product: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
is described by: ECO:0000000
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
reversible: false
is: SBO:0000176

metaR NAHCO3 HCLt
name: bicarbonate transport (HCl/NaHCO3 exchange)
reactant: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
modifier: MODEL1310110011#
reversible: true

metaM 3thexddcoacrn e
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C23H41NO5 CHARGE: 0
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
is: HMDB02014

http://identifiers.org/biomodels.db/MODEL1310110011#_407f5505_987a_456d_897a_ec3bdedf343b
type: Species
constant: false
initial amount: NaN
name: PAPSS2
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: O95340
is encoded by: hsa:9060
boundary condition: true

metaR RE3005M
modifier: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reversible: true
name: RE3005
is described by: ECO:0000000
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110011#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
fast: false

metaR ASNCYSNaEx
modifier: MODEL1310110011#
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
fast: false
type: Reaction
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110011#
reversible: false
is described by: ECO:0000269

metaM HC02210 c
constant: false
name: prostaglandin-d3
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
is: CHEBI:34939
initial amount: NaN
boundary condition: false

metaM hexdiac r
initial amount: NaN
is: HMDB00672
is: C08260
initial concentration: 1.0
name: hexadecanediocacid
is: SBO:0000247
notes: FORMULA: C16H28O4 CHARGE: -2
constant: false
boundary condition: false
type: Species
has only substance units: false

metaM 5pmev x
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
is: HMDB01343
initial concentration: 1.0
is: CHEBI:58146
initial amount: NaN
constant: false
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00670 EHMN_ABBREVIATION: C01107
name: (R)-5-phosphonatomevalonate(3-)

metaM 3thexddcoacrn c
type: Species
constant: false
notes: FORMULA: C23H41NO5 CHARGE: 0
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB02014
is: SBO:0000247
initial amount: NaN
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine

metaR GPIMTer L
product: MODEL1310110011#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
reversible: false
modifier: MODEL1310110011#
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#

metaR FAOXC163C143m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:3)m
type: Reaction

metaR COAtp
reversible: true
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110011#
fast: false
type: Reaction
name: coenzyme A transport, peroxisomal
kinetic law: MODEL1310110011#

metaR r1668
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110011#
type: Reaction
is: SBO:0000185
product: MODEL1310110011#
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
reversible: true
fast: false
name: Y+LAT2 Utilized transport

metaM btcoa m
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB01088
is: CHEBI:57371
type: Species
has only substance units: false
initial concentration: 1.0
is: C00136
name: Butanoyl-CoA
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136

metaR r0706
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.99.10
fast: false
reversible: false
is described by: ECO:0000000
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
type: Reaction

metaR r1810
type: Reaction
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110011#
name: Y+LAT2 Utilized transport
fast: false
reversible: false
reactant: MODEL1310110011#
is: SBO:0000185
product: MODEL1310110011#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110011#_6b249e3a_1843_4651_ab96_73e2d50a0539
name: SCD
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6319
is: O00767
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false

metaR ACOAD8m
notes: GENE_ASSOCIATION: (3712.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 4 AUTHORS: PMID:9214289 NOTES:MM
product: MODEL1310110011#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110011#
reversible: false
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.10
modifier: MODEL1310110011#
is: SBO:0000176
kinetic law: MODEL1310110011#

metaR r1669
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110011#
reversible: true
name: Y+LAT2 Utilized transport
reactant: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110011#
kinetic law: MODEL1310110011#

metaR RE1807C
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reversible: true
name: RE1807
type: Reaction

metaM HC02210 e
name: prostaglandin-d3
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
constant: false
is: SBO:0000247
is: CHEBI:34939
boundary condition: false

metaR CYTK12n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110011#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110011#
type: Reaction
name: cytidylate kinase (dCMP,dCTP),nuclear
reversible: true
kinetic law: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR TTDCAFATPc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaM thr L e
type: Species
boundary condition: false
is: CHEBI:16857
is: SBO:0000247
name: L-threonine
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00167
constant: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179

metaR RE0915E
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.17
kinetic law: MODEL1310110011#
type: Reaction
reversible: true
is described by: ECO:0000000
name: RE0915
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.2.1.1
product: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:

metaR S23T3g
reactant: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.6
product: MODEL1310110011#
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110011#
is described by: ECO:0000000
fast: false

metaM hco3 m
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
constant: false
is: HMDB00595
is: SBO:0000247
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: C00288
name: Bicarbonate
is: CHEBI:17544

metaR r0186
kinetic law: MODEL1310110011#
fast: false
is: SBO:0000176
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
type: Reaction
reactant: MODEL1310110011#
modifier: MODEL1310110011#
reversible: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
product: MODEL1310110011#

metaR DECDICRNe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of decadienoyl carnitine into the extra cellular space
type: Reaction

metaR COAtr
is: SBO:0000185
name: COA transporter, endoplasmic reticulum
reversible: true
kinetic law: MODEL1310110011#
product: MODEL1310110011#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110011#
is described by: ECO:0000000

metaR EX hpdca LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptadecanoate exchange
type: Reaction

metaR CYTK1n
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
kinetic law: MODEL1310110011#
is described by: ECO:0000269
modifier: MODEL1310110011#
is: SBO:0000176
reactant: MODEL1310110011#
type: Reaction
name: cytidylate kinase (CMP),nuclear

metaM acgam r
is: SBO:0000247
boundary condition: false
is: HMDB00215
constant: false
name: N-acetyl-D-glucosamine
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: CHEBI:17411

metaM ppcoa c
is: CHEBI:57392
has only substance units: false
boundary condition: false
name: Propanoyl-CoA
is: HMDB01275
is: C00100
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial concentration: 1.0
constant: false
type: Species

metaM CE2431 m
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
constant: false
name: cis-deca-4-enoyl-CoA
boundary condition: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
is: C01936

http://identifiers.org/biomodels.db/MODEL1310110011#_98db1eba_6f28_4fb6_b2b3_34f8a3e97f40
constant: false
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:23761
is: Q9UG56
is: SBO:0000252
initial amount: NaN
name: PISD

http://identifiers.org/biomodels.db/MODEL1310110011#_0efc3127_da16_44e9_9a1d_d171c73689fa
is: SBO:0000252
type: Species
is encoded by: hsa:1384
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
name: CRAT

http://identifiers.org/biomodels.db/MODEL1310110011#_3fd59635_59b9_4d1e_9aee_e26268cf7fc6
is: B3KMA6
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:2181
boundary condition: true
name: ACSL3
initial amount: NaN

metaR r1812
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110011#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110011#
product: MODEL1310110011#
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110011#

metaM gthox m
constant: false
is: CHEBI:58297
initial concentration: 1.0
is: HMDB03337
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN

metaM CE0713 m
is: SBO:0000247
type: Species
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
constant: false
boundary condition: false
is: HMDB02329
has only substance units: false
name: 3-oxolinoleoyl-CoA
initial concentration: 1.0
initial amount: NaN
is: CHEBI:30623

metaM ru5p D c
constant: false
name: D-ribulose 5-phosphate(2-)
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
type: Species
initial concentration: 1.0
is: HMDB00618
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:58121
is: SBO:0000247

metaM hpdcacoa c
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
name: heptadecanoyl coa
constant: false
is: HMDB06497
initial concentration: 1.0
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
is: SBO:0000247

metaM tetdece1crn e
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: tetradecenoyl carnitine
has only substance units: false
constant: false
type: Species
notes: FORMULA: C21H39NO4 CHARGE: 0
is: SBO:0000247
is: HMDB02014

metaM g3m8masn r
initial concentration: 1.0
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false
type: Species
constant: false
boundary condition: false
is: SBO:0000247
is: C05873
notes: FORMULA: C88H147N2O70X CHARGE: 0
initial amount: NaN

metaR FAOXC164C165m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

metaM CE2418 m
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
constant: false
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
is: CHEBI:28387
is: SBO:0000247
is: HMDB11123

metaM hdca r
type: Species
name: Hexadecanoate (n-C16:0)
initial concentration: 1.0
constant: false
is: HMDB00220
boundary condition: false
is: C00249
initial amount: NaN
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
has only substance units: false
is: CHEBI:7896
is: SBO:0000247

metaR ALAGLNexR
fast: false
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
reversible: true
modifier: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000304
name: L-alanine/glutamine reversible exchange
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_c68e05b3_6988_4a75_beec_2bd6a8fd2d34
is: Q6IRT1
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:128
constant: false
initial amount: NaN
boundary condition: true
type: Species
name: ADH5
has only substance units: false

metaM acgam l
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:17411
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
name: N-acetyl-D-glucosamine
type: Species
is: HMDB00215
is: SBO:0000247
has only substance units: false

metaR HDCEAtr
reversible: true
fast: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#
name: fatty acid transport via diffusion
is: SBO:0000185
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
type: Reaction

metaR GK1
fast: false
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.4.8
is: SBO:0000176
kinetic law: MODEL1310110011#
name: guanylate kinase (GMP:ATP)
product: MODEL1310110011#
modifier: MODEL1310110011#
reversible: true
is described by: ECO:0000269
type: Reaction

metaR G14T5g
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110011#
reversible: false
modifier: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90

metaR COAtm
reversible: true
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
name: CoA transporter
type: Reaction
fast: false
product: MODEL1310110011#
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only

http://identifiers.org/biomodels.db/MODEL1310110011#_2d72f250_0aae_402e_ad72_dd9ef200db26
is: SBO:0000252
type: Species
is: Q8N142
name: ADSSL1
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:122622

http://identifiers.org/biomodels.db/MODEL1310110011#_c48860ff_3f69_4bd3_bcc7_d7576b464b1d
is: Q9NQU1
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: SLC26A6
type: Species
has only substance units: false
is encoded by: hsa:65010

metaR SEBACACT
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of sebacic acidd
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_57ec9776_7654_4b74_b969_d88aae1cb5e3
is encoded by: hsa:AA081045
type: Species
is: SBO:0000252
initial concentration: NaN
name: _AA081045_1_m
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_70d14e68_6876_40b6_9c86_3a3e6d5a57a3
is encoded by: hsa:4846
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is: A0S0A7
is: SBO:0000252
type: Species
name: NOS3
initial amount: NaN

metaR r2071
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
modifier: MODEL1310110011#
is: SBO:0000185
product: MODEL1310110011#

metaR C3DCe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of malonyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_363cb318_c6e7_4a63_bc80_e393fc951151
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:10768
constant: false
boundary condition: true
name: AHCYL1
has only substance units: false
is: SBO:0000252

metaR r1960
fast: false
is described by: ECO:0000000
product: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110011#
is: SBO:0000185
name: Y+LAT2 Utilized transport
reactant: MODEL1310110011#
reversible: false
kinetic law: MODEL1310110011#

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaM dcsptn1coa x
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: HMDB06513
type: Species
is: http://identifiers.org/pubchem.compound/47205483
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
initial amount: NaN
is: SBO:0000247
constant: false
is: C16173
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_05e7cd5a_4431_410f_a6b5_900c1847e65f
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: TALDO1
has only substance units: false
is: P37837
is encoded by: hsa:6888
initial amount: NaN

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

metaR AG13T4g
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110011#
product: MODEL1310110011#
modifier: MODEL1310110011#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110011#
type: Reaction
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110011#_af99488f_2e1c_4b5b_b56d_772b10f71563
boundary condition: true
is encoded by: hsa:5142
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
is: Q5TEK5
has only substance units: false
name: PDE4B

metaM tetdece1crn c
notes: FORMULA: C21H39NO4 CHARGE: 0
name: tetradecenoyl carnitine
is: HMDB02014
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM 3hexdcoa c
initial concentration: 1.0
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB03932
constant: false
type: Species
is: C05258
boundary condition: false
name: 3-hydroxyhexadecanoylcoa

http://identifiers.org/biomodels.db/MODEL1310110011#_24dada28_2947_4c5c_ae07_05029a63be50
constant: false
boundary condition: true
initial concentration: NaN
name: NPR2
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4882

metaM camp c
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
name: 3',5'-cyclic AMP(1-)
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00058
type: Species
is: CHEBI:58165
constant: false
is: SBO:0000247

metaR COAtn
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
reversible: true
type: Reaction
name: coenzyme A transport, nuclear
reactant: MODEL1310110011#

metaR PItn
is: SBO:0000185
product: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110011#
name: phosphate transport, nuclear

http://identifiers.org/biomodels.db/MODEL1310110011#_5df531fc_8827_427e_ab66_736a17672100
type: Species
name: _7359_1_c
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:7359
boundary condition: true
has only substance units: false
constant: false

metaM ksi pre26 g
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 26
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
is: CHEBI:28067
initial amount: NaN
has only substance units: false
type: Species

metaM amet m
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01185
initial amount: NaN
constant: false
name: S-Adenosyl-L-methionine
is: C00019
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
type: Species
is: CHEBI:15414

metaR r1961
is: SBO:0000185
modifier: MODEL1310110011#
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110011#
kinetic law: MODEL1310110011#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM octe5coa m
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
has only substance units: false
name: 5-octenoylcoa
type: Species
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
constant: false

metaR KYNAKGAT
is version of: http://identifiers.org/ec-code/2.6.1.7
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.64
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
kinetic law: MODEL1310110011#
is: SBO:0000176
name: L-Kynurenine:2-oxoglutarate aminotransferase
type: Reaction
product: MODEL1310110011#
modifier: MODEL1310110011#
reversible: false
fast: false
reactant: MODEL1310110011#

metaR ALADGLNexR
modifier: MODEL1310110011#
name: L-alanine/glutamine reversible exchange
reversible: true
reactant: MODEL1310110011#
is described by: ECO:0000304
kinetic law: MODEL1310110011#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110011#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_81a76b88_fffc_4697_bc47_38e25335bac8
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
name: _AA526438_1_c
is encoded by: hsa:AA526438

metaR r0181
reversible: true
is: SBO:0000176
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110011#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110011#
product: MODEL1310110011#

metaM glyald c
boundary condition: false
constant: false
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
name: D-Glyceraldehyde
is: HMDB01051
is: C00577
initial concentration: 1.0
is: CHEBI:17378
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN

metaM thr L c
constant: false
initial concentration: 1.0
is: SBO:0000247
name: L-threonine
has only substance units: false
type: Species
is: CHEBI:16857
is: HMDB00167
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_2b056679_f983_40f5_8e19_9bc50927f0dd
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:5831
boundary condition: true
constant: false
name: PYCR1
has only substance units: false
is: P32322

metaR THFtm
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
fast: false
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
is: SBO:0000185
product: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#

metaR EX bildglcur LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin beta-diglucuronide exchange
type: Reaction

metaR ADPCOAPTE
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of adipoyl coA for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_af1127b5_bbd4_40df_872a_5b5417ca6ca3
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: PDE9A
is encoded by: hsa:5152
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_1d55fa3f_642a_4db6_9199_4d3e251da9d3
initial concentration: NaN
is: P09923
name: ALPI
type: Species
initial amount: NaN
is encoded by: hsa:248
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false

metaM ptdca e
is: http://identifiers.org/pubchem.compound/22169126
boundary condition: false
type: Species
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
is: HMDB00826
initial concentration: 1.0
name: pentadecanoate
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false

metaR EX CE5853 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-CEHC-glucuronide exchange
type: Reaction

metaR DDCRNe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydodecanoyl carnitine into extra cellular space
type: Reaction

metaM glyald m
type: Species
initial amount: NaN
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial concentration: 1.0
boundary condition: false
is: CHEBI:17378
has only substance units: false
is: HMDB01051
constant: false
name: D-glyceraldehyde
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_e869b200_478b_48e0_a2bd_927a140f747e
is: Q9HC21
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:60386
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
name: SLC25A19

metaR H2O2tp
reversible: true
fast: false
reactant: MODEL1310110011#
is described by: ECO:0000000
name: hydrogen peroxide peroxisomal transport via diffusion
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
product: MODEL1310110011#

metaM 3hpcoa m
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
constant: false
type: Species
is: SBO:0000247
is: CHEBI:58528
initial amount: NaN
boundary condition: false
is: HMDB06807
name: 3-hydroxypropanoyl-CoA(4-)

metaR DUTPDP
name: dUTP diphosphatase
is described by: ECO:0000134
kinetic law: MODEL1310110011#
reversible: false
type: Reaction
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: Confidence Level: 3 AUTHORS: NOTES:
reactant: MODEL1310110011#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110011#_0dbcbd89_37fa_4ceb_a2aa_6a862118c8a8
name: _AA576959_1_c
constant: false
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AA576959
has only substance units: false

metaM trp L c
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
boundary condition: false
is: HMDB00929
is: SBO:0000247
type: Species
name: L-tryptophan
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:16828
initial concentration: 1.0

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaM 5forthf c
boundary condition: false
constant: false
name: 5-Formiminotetrahydrofolate
has only substance units: false
initial amount: NaN
type: Species
is: C00664
initial concentration: 1.0
is: CHEBI:57456
is: HMDB01534
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_dd9edb4f_f977_443f_b344_aeea0f676601
boundary condition: true
type: Species
constant: false
name: SLC9A1
initial amount: NaN
is: P19634
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6548

metaM ppa c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: HMDB00237
has only substance units: false
name: propionate
is: CHEBI:17272
initial concentration: 1.0
constant: false
boundary condition: false
type: Species

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_e4ce3799_6dd7_477a_8d78_bbb8f11c5115
is encoded by: hsa:R06874
has only substance units: false
name: _R06874_1_r
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false

metaR SR5ARr
kinetic law: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.99.5
fast: false
is described by: ECO:0000134
reactant: MODEL1310110011#
reversible: false
type: Reaction
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110011#_00b7f2db_3760_43d7_8253_9430eb06f08c
boundary condition: true
is encoded by: hsa:222
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ALDH3B2
constant: false
initial concentration: NaN
is: P48448

metaR r1672
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR C162ACBP
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxy trans7,10-hexadecadienoylcoa from mitochondria into cytosol
type: Reaction

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaM dcholcoa c
constant: false
has only substance units: false
is: HMDB06292
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: chenodeoxycholoyl coenzyme a
is: CHEBI:28701
boundary condition: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
type: Species

metaR C140CPT1
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of myristoylcarnitine
type: Reaction

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaM chsterol e
constant: false
initial concentration: 1.0
boundary condition: false
name: cholesterol
initial amount: NaN
has only substance units: false
is: CHEBI:16113
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: HMDB00067
type: Species
is: SBO:0000247

metaM ptdca c
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/22169126
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
type: Species
name: pentadecanoate
is: HMDB00826
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false

metaM lneldc e
type: Species
name: linoelaidic acid (all trans C18:2)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
initial amount: NaN
constant: false
has only substance units: false
is: HMDB06270

metaR C141OHe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:1-OH
type: Reaction

metaM cl e
is: C00115
constant: false
is: HMDB00492
is: CHEBI:3966
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: Cl CHARGE: -1
name: Chloride
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false

metaR GPIDAer
type: Reaction
product: MODEL1310110011#
is described by: ECO:0000000
modifier: MODEL1310110011#
is: SBO:0000176
reversible: false
reactant: MODEL1310110011#
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
kinetic law: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD

metaR GLYt7 211 r
product: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: glycine reversible transport via sodium and chloride symport (2:1:1)
type: Reaction
reversible: true
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
is described by: ECO:0000269
is: SBO:0000185

metaR r0450
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/4.2.1.3
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: true
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:

metaR r2081
kinetic law: MODEL1310110011#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_a2f3484a_55f9_450f_88ad_12e0606e68db
is: Q8NB10
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
name: PDE1C
is encoded by: hsa:5137
initial concentration: NaN
constant: false

metaM trp L e
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00929
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
type: Species
boundary condition: false
name: L-tryptophan
constant: false
has only substance units: false
is: CHEBI:16828

metaM HC02217 e
name: prostaglandin-g2
initial concentration: 1.0
is: CHEBI:27647
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_7e67bdb2_75d6_4e6c_ac17_2a032516c0bb
is: D3DTL2
initial amount: NaN
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: ENO3
has only substance units: false
is encoded by: hsa:2027

http://identifiers.org/biomodels.db/MODEL1310110011#_421acfee_f69a_4b84_8eac_054892531484
initial amount: NaN
is: Q6P1K9
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
name: PANK2
is encoded by: hsa:80025

metaM 12ppd S c
constant: false
initial amount: NaN
initial concentration: 1.0
name: (S)-propane-1,2-diol
boundary condition: false
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
is: CHEBI:29002
type: Species
has only substance units: false
is: HMDB06213
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_e7c113d5_872f_4bb8_8026_6ec5a8e99d59
type: Species
name: _AA203143_1_c
initial amount: NaN
is encoded by: hsa:AA203143
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true

metaR r2080
product: MODEL1310110011#
is: SBO:0000185
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110011#_c416690f_a52f_42a2_98c5_dc2f036c22f4
is encoded by: hsa:80025
constant: false
initial amount: NaN
type: Species
boundary condition: true
name: PANK2
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM prostgh2 e
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial amount: NaN
constant: false
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:57405
is: HMDB01381
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin H2(1-)

metaR r0451
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
reversible: false
fast: false
product: MODEL1310110011#
is described by: ECO:0000000
reactant: MODEL1310110011#
is: SBO:0000176
kinetic law: MODEL1310110011#
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) Lysine degradation EC:1.2.4.2

http://identifiers.org/biomodels.db/MODEL1310110011#_4377bb00_4615_493c_a53f_81bd065c24a9
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: AMPD3
initial amount: NaN
is: B7Z763
type: Species
constant: false
is encoded by: hsa:272
has only substance units: false

metaM 3pg c
has only substance units: false
is: C00197
is: CHEBI:58272
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3497
type: Species
is: HMDB00807
name: 3-Phospho-D-glycerate
is: SBO:0000247
constant: false

metaM lneldc c
is: HMDB06270
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
has only substance units: false
initial amount: NaN
constant: false
name: linoelaidic acid (all trans C18:2)
initial concentration: 1.0

metaR C141OHc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecenoyl carnitine
type: Reaction

metaM gam c
constant: false
name: D-Glucosamine
is: C00329
initial amount: NaN
boundary condition: false
is: HMDB01514
has only substance units: false
type: Species
is: CHEBI:17315
is: SBO:0000247
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
initial concentration: 1.0

metaR DURIK1
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:
name: deoxyuridine kinase (ATP:Deoxyuridine)
is version of: http://identifiers.org/ec-code/2.7.1.21
fast: false
reactant: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
reversible: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000254
is: SBO:0000176

metaM tyr L e
is: HMDB00158
is: CHEBI:17895
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial concentration: 1.0
initial amount: NaN
name: L-tyrosine
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_258020b6_3577_4011_8db5_ebd4f57a65b8
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:79717
is: Q9HAB8
name: PPCS
initial amount: NaN
is: SBO:0000252

metaR r0456
is version of: http://identifiers.org/ec-code/2.3.1.21
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
modifier: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
reversible: false
product: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.32
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110011#_44c9926e_7c8b_4946_91cc_f0bd6d233830
is encoded by: hsa:5277
constant: false
initial concentration: NaN
is encoded by: hsa:5283
initial amount: NaN
is encoded by: hsa:5279
is encoded by: hsa:9091
has part: Q9BRB3
has part: Q14442
type: Species
is: SBO:0000297
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:51227
boundary condition: true
has part: B3KUV7
is encoded by: hsa:8818
has part: O94777
has part: Q92535
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_174a7aaa_d6e1_4327_9907_59f0805dc8c9
initial amount: NaN
is encoded by: hsa:AI620219
initial concentration: NaN
name: _AI620219_1_c
constant: false
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR ADK3
reversible: true
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
reactant: MODEL1310110011#
is: SBO:0000176
type: Reaction
product: MODEL1310110011#
name: adentylate kinase (GTP)
is described by: ECO:0000269
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
modifier: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_ba5f8c27_0a5a_417b_86f3_c2fb28b89edb
is encoded by: hsa:3706
constant: false
name: ITPKA
is: P23677
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

metaM chsterol l
initial amount: NaN
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: HMDB00067
is: CHEBI:16113
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: cholesterol
boundary condition: false

metaR EX elaid LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: elaidic acid exchange
type: Reaction

metaM cholcoa x
is: CHEBI:57373
has only substance units: false
name: choloyl-CoA(4-)
is: SBO:0000247
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB01374
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_13fe3ad9_7530_41dc_8878_4890f235d4ba
is encoded by: hsa:1650
initial amount: NaN
initial concentration: NaN
has part: P39656
is encoded by: hsa:1603
boundary condition: true
name: DAD1:DDOST:RPN1:RPN2
is: SBO:0000297
has part: Q53G02
type: Species
is encoded by: hsa:6184
has part: P04844
has part: P04843
is encoded by: hsa:6185
has only substance units: false
constant: false

metaM HC02217 c
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: CHEBI:27647
is: SBO:0000247
boundary condition: false
name: prostaglandin-g2
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_dd37196c_9b6b_4836_b28f_8cb078c2d9b9
type: Species
boundary condition: true
initial concentration: NaN
is: O15245
has only substance units: false
name: SLC22A1
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6580

http://identifiers.org/biomodels.db/MODEL1310110011#_cd003c3b_3d67_4697_b0a7_174f67cb4417
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:10588
is: P49914
type: Species
initial amount: NaN
is: SBO:0000252
name: MTHFS
boundary condition: true

metaR EX c5dc
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glutaryl carnitine
type: Reaction

metaM glyc S e
is: CHEBI:33871
name: (S)-Glycerate
boundary condition: false
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB06372
notes: FORMULA: C3H5O4 CHARGE: 0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_4df02798_7d9d_4750_a523_ea2bf6e12b48
is encoded by: hsa:217
is: P05091
boundary condition: true
type: Species
constant: false
has only substance units: false
initial concentration: NaN
name: ALDH2
initial amount: NaN
is: SBO:0000252

metaR ARACHDtr
is: SBO:0000185
kinetic law: MODEL1310110011#
reversible: true
product: MODEL1310110011#
is described by: ECO:0000000
reactant: MODEL1310110011#
type: Reaction
name: intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
fast: false

metaM chsterol m
is: CHEBI:16113
initial amount: NaN
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial concentration: 1.0
has only substance units: false
constant: false
name: cholesterol
type: Species
is: HMDB00067
boundary condition: false
is: SBO:0000247

metaM tyr L c
initial amount: NaN
is: HMDB00158
is: CHEBI:17895
has only substance units: false
name: L-tyrosine
constant: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species

metaM gam e
is: C00329
initial amount: NaN
name: D-Glucosamine
is: HMDB01514
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:17315
has only substance units: false
constant: false
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_eda618e9_43c9_491f_9b0e_bd2193fe6955
type: Species
boundary condition: true
name: B3GNT2
initial amount: NaN
is encoded by: hsa:10678
is: Q9NY97
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false

metaR TRPHYDRO2
reversible: false
product: MODEL1310110011#
is: SBO:0000176
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.14.16.4
is described by: ECO:0000269
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
fast: false
type: Reaction
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
modifier: MODEL1310110011#

metaM 3php c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: 3-phosphonatooxypyruvate(3-)
boundary condition: false
is: HMDB01024
type: Species
constant: false
is: CHEBI:18110
notes: FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232

metaM hexdtrcoa m
is: HMDB02288
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
name: 7,10,13-hexadecatrienoylcoa
type: Species
initial amount: NaN
boundary condition: false

metaR DCSPTN1t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110011#
is: SBO:0000185
reactant: MODEL1310110011#
fast: false
reversible: true
name: fatty acid transport via diffusion
product: MODEL1310110011#
is described by: ECO:0000000
type: Reaction

metaM 3ivcoa c
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
initial amount: NaN
type: Species
is: HMDB06870
initial concentration: 1.0
boundary condition: false
is: C05998
has only substance units: false
name: 3-hydroxyisovalerylcoa
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/11966188

http://identifiers.org/biomodels.db/MODEL1310110011#_9c64ffc8_6f4e_4df3_b6ea_20fb72bcdbed
boundary condition: true
is encoded by: hsa:292
constant: false
has only substance units: false
initial amount: NaN
is: Q6NVC0
name: SLC25A5
type: Species
initial concentration: NaN
is: SBO:0000252

metaR PGDI
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.5.1.18
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
name: Prostaglandin-H2 D-isomerase [Precursor]
kinetic law: MODEL1310110011#
reversible: true
product: MODEL1310110011#
modifier: MODEL1310110011#
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/5.3.99.2

metaR SRTNt6 2 r
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
product: MODEL1310110011#
reversible: true
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110011#
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_caadfd97_990c_4608_9bb8_ea52a859a7c1
is: SBO:0000297
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: SLC7A8:SLC3A2
constant: false
has part: Q86U05
is encoded by: hsa:23428

metaR RE3218C
type: Reaction
fast: false
product: MODEL1310110011#
kinetic law: MODEL1310110011#
name: RE3218
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
modifier: MODEL1310110011#
reactant: MODEL1310110011#

metaM co e
name: carbon monoxide
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
is: CHEBI:17245
is: SBO:0000247
constant: false
is: HMDB01361

http://identifiers.org/biomodels.db/MODEL1310110011#_e5e77afb_445a_4254_b81a_491b0122aa2f
is encoded by: hsa:57786
is: SBO:0000252
boundary condition: true
constant: false
is: Q9NYW8
type: Species
initial amount: NaN
name: RBAK
has only substance units: false
initial concentration: NaN

metaM dlnlcgcoa r
is: C03595
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
name: dihomo-gamma-linolenyl coenzyme A
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:27979
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102

metaM glyc S c
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C3H5O4 CHARGE: 0
is: CHEBI:33871
is: SBO:0000247
name: (S)-Glycerate
is: HMDB06372
initial amount: NaN
boundary condition: false

metaR DNDPt18m
is: SBO:0000185
kinetic law: MODEL1310110011#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110011#
reactant: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
name: dUDP transport via ADP antiport
fast: false

metaM HC10852 r
initial amount: NaN
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
boundary condition: false
is: SBO:0000247
constant: false
type: Species
name: palmitoleyl-CoA(4-)
is: CHEBI:61540
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_893d48b1_81bb_4cbe_8cfc_1e840c939e52
type: Species
is encoded by: hsa:159963
has only substance units: false
initial concentration: NaN
is: Q1EHB4
initial amount: NaN
boundary condition: true
constant: false
name: SLC5A12
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_7492ac10_d617_4230_a31c_21e64b3b7d68
is encoded by: hsa:AI934540
type: Species
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: _AI934540_1_c
initial amount: NaN

metaM ppa e
constant: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: CHEBI:17272
type: Species
has only substance units: false
is: HMDB00237
is: SBO:0000247
name: propionate
boundary condition: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_e5b7fcc6_89ab_41ab_a053_515959c8152f
name: _AW277253_1_c
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AW277253
boundary condition: true
is: SBO:0000252
type: Species

metaR G3PD1
is described by: ECO:0000269
modifier: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.1.8
name: glycerol-3-phosphate dehydrogenase (NAD)
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
is: SBO:0000176
reversible: true
fast: false
product: MODEL1310110011#
reactant: MODEL1310110011#

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR FAOXC161C141m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:1-->C14:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_63f5632b_d2ad_4b9b_bf70_18e9e8899873
initial amount: NaN
is: P11166
name: SLC2A1
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6513

metaM pan4p c
name: Pantetheine 4'-phosphate
type: Species
is: HMDB01416
is: CHEBI:47942
has only substance units: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
boundary condition: false
is: C01134
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaR SUCCt2m
product: MODEL1310110011#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
kinetic law: MODEL1310110011#
is: SBO:0000185
modifier: MODEL1310110011#
type: Reaction
name: succinate transport, mitochondrial
fast: false
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_91fd9cba_c16e_419d_ab6b_84f109ec7c36
constant: false
initial amount: NaN
is encoded by: hsa:112724
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: RDH13
type: Species
is: B3KVA3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_2b42e14d_5806_4b22_80ee_bfd7e3979e4a
is: P04075
initial concentration: NaN
name: ALDOA
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:226
is: SBO:0000252
type: Species

metaR RE1897C
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
kinetic law: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110011#
fast: false
name: RE1897
is: SBO:0000176
reactant: MODEL1310110011#
reversible: true

metaM 3pg m
initial concentration: 1.0
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
is: HMDB00807
is: CHEBI:58272
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species

metaR RE1447N
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110011#
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
name: RE1447
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
reversible: true
fast: false

metaM HC01409 m
boundary condition: false
constant: false
name: Hexanoyl-CoA
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:27540
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_4b9b4905_f4b9_497c_8ba7_3cc840c868da
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1608
is: SBO:0000252
is: P49619
has only substance units: false
name: DGKG
boundary condition: true
type: Species

metaR FUMAC
reactant: MODEL1310110011#
reversible: false
kinetic law: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.7.1.2
is: SBO:0000176
modifier: MODEL1310110011#
name: fumarylacetoacetase
product: MODEL1310110011#
fast: false

metaR EX 3thexddcoacrn
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy trans7,10-hexadecadienoyl carnitine
type: Reaction

metaM ru5p D r
is: CHEBI:58121
is: HMDB00618
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
name: D-ribulose 5-phosphate(2-)
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_503bda69_19da_49b0_9077_61d44f6a46ea
name: AK4
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:205
is: P27144
constant: false
initial amount: NaN

metaR CYSALANaEx
name: L-alanine/L-cysteine Na-dependent exchange (Cys-L in)
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000185
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
product: MODEL1310110011#
type: Reaction

metaM acgam c
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00215
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
name: N-acetyl-D-glucosamine
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:17411
boundary condition: false

metaM dlnlcgcoa m
is: CHEBI:27979
is: SBO:0000247
initial amount: NaN
type: Species
name: dihomo-gamma-linolenyl coenzyme A
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_7c18c2d0_c58d_4068_9254_2d2786942655
constant: false
initial concentration: NaN
name: NDUFA3
boundary condition: true
type: Species
is: SBO:0000252
is: O95167
has only substance units: false
is encoded by: hsa:4696
initial amount: NaN

metaR S6T10g
reversible: false
kinetic law: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
reactant: MODEL1310110011#
product: MODEL1310110011#
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaR RE0512M
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110011#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE0512
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM ala D e
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
name: D-alanine
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB01310
type: Species
constant: false
is: CHEBI:15570
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_3c496816_b9cb_427e_978a_dd03eef7644f
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:33
boundary condition: true
is: P28330
name: ACADL

metaR DM atp c
type: Reaction
reactant: MODEL1310110011#
is: SBO:0000176
kinetic law: MODEL1310110011#
product: MODEL1310110011#
fast: false
is described by: ECO:0000134
name: DM_atp(c)
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110011#_4705a878_3bfe_4381_a1c2_3339fa73e7b4
type: Species
name: ALG3
is encoded by: hsa:10195
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_8680ce2b_560f_42dc_b19c_f3f12da05f4c
is: SBO:0000252
type: Species
initial concentration: NaN
name: _AA664770_1_m
is encoded by: hsa:AA664770
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false

metaR HMGCOAtm
reversible: true
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
fast: false
product: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_2d198b1c_4153_4451_bc50_944e89e69cbb
initial amount: NaN
has only substance units: false
is: Q96CA6
is encoded by: hsa:30
constant: false
boundary condition: true
is: SBO:0000252
name: ACAA1
initial concentration: NaN
type: Species

metaM mev R c
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:36464
is: HMDB00227
is: SBO:0000247
name: (R)-mevalonate
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_fc4679b9_28b6_480e_9c51_b2551efb7c58
type: Species
initial concentration: NaN
boundary condition: true
is: P19801
constant: false
is encoded by: hsa:26
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ABP1

metaM 3ttetddcoa m
type: Species
is: HMDB02014
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
name: 3-hydroxy trans5,8tetradecadienoyl coa
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C35H54N7O18P3S CHARGE: -4

metaR EX 3octdece1crn
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-octadecenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_1d1f4e16_38dd_41c5_882b_8c90d48f41dd
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:91373
constant: false
is: Q3KQV9
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: UAP1L1

metaR EX CE1925 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3'-carboxy-alpha-chromanol exchange
type: Reaction

metaM hdca c
name: palmitate
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:7896
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: HMDB00220
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species

metaR DHORTS
kinetic law: MODEL1310110011#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
is: SBO:0000176
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.1.3.2
modifier: MODEL1310110011#
reversible: true
is described by: ECO:0000269
name: dihydroorotase
product: MODEL1310110011#

metaR BAAT2x
is: SBO:0000176
modifier: MODEL1310110011#
is described by: ECO:0000269
name: bile acid Coenzyme A: amino acid N-acyltransferase
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
product: MODEL1310110011#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.65

metaR MCITS
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 2.3.3.5 Confidence Level: 2 AUTHORS: PMID:426765,PMID:4507604 NOTES:NCD new EC is 2.3.3.5 - NCD
type: Reaction
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: 2-methylcitrate synthase

metaR EX 2mcit LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Methylcitrate exchange
type: Reaction

metaR UAG2EMAi
is described by: ECO:0000269
product: MODEL1310110011#
type: Reaction
is: SBO:0000176
fast: false
name: UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:
reversible: false
reactant: MODEL1310110011#
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/5.1.3.14
kinetic law: MODEL1310110011#

metaR FAOXC184C164m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)m
type: Reaction

metaM ala D c
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
has only substance units: false
is: HMDB01310
is: SBO:0000247
type: Species
constant: false
is: CHEBI:15570
name: D-alanine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_5aec56cf_b4be_4d8c_b11e_03430616d280
boundary condition: true
initial amount: NaN
name: ALAS1
is: P13196
has only substance units: false
constant: false
is encoded by: hsa:211
is: SBO:0000252
type: Species
initial concentration: NaN

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_bbf1fa4d_06ce_4f4c_9128_a10e67d7c9c1
boundary condition: true
is encoded by: hsa:AI971036
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: _AI971036_1_c
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_0db653f7_f5f4_4e59_859c_bb2a7621a219
is: O76062
initial amount: NaN
is encoded by: hsa:7108
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
name: TM7SF2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_9ff86ec9_6115_4c44_9402_d8871a7a45aa
has only substance units: false
boundary condition: true
name: SLC23A1
is encoded by: hsa:9963
type: Species
is: Q9UHI7
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN

metaM cl c
is: SBO:0000247
name: Chloride
initial concentration: 1.0
initial amount: NaN
is: C00115
is: HMDB00492
is: CHEBI:3966
type: Species
notes: FORMULA: Cl CHARGE: -1
has only substance units: false
constant: false
boundary condition: false

metaR ALASERNaEx
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
type: Reaction
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000269
name: L-alanine/L-serine Na-dependent exchange (Ala-L in)
is: SBO:0000185
modifier: MODEL1310110011#
fast: false
product: MODEL1310110011#

metaM chsterol c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB00067
boundary condition: false
type: Species
name: cholesterol
is: CHEBI:16113
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

metaR r0870
is version of: http://identifiers.org/ec-code/3.6.1.1
type: Reaction
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.6.4.13
is version of: http://identifiers.org/ec-code/2.7.7.72
reversible: true
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
fast: false
product: MODEL1310110011#
name: Facilitated diffusion
modifier: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.1.3.4

http://identifiers.org/biomodels.db/MODEL1310110011#_03e468af_94ca_47ea_91cf_94abdc08e4ee
initial concentration: NaN
is: Q9GZS9
type: Species
initial amount: NaN
is encoded by: hsa:23563
is: SBO:0000252
name: CHST5
has only substance units: false
constant: false
boundary condition: true

metaR DLNLCGt
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110011#
reversible: true
fast: false
name: fatty acid transport via diffusion
type: Reaction
product: MODEL1310110011#

metaM malt e
constant: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
initial concentration: 1.0
initial amount: NaN
name: Maltose
is: CHEBI:17306
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
is: C00208
is: HMDB00163

metaM tyr L m
name: L-tyrosine
boundary condition: false
constant: false
has only substance units: false
is: HMDB00158
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17895
type: Species
is: SBO:0000247
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085

metaR r1512
name: Utilized transport
is described by: ECO:0000000
type: Reaction
product: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110011#
is: SBO:0000185
reactant: MODEL1310110011#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110011#_d17fba84_884f_4168_9afa_55ebb20ca8ad
constant: false
boundary condition: true
is: Q06278
initial concentration: NaN
is encoded by: hsa:316
initial amount: NaN
type: Species
is: SBO:0000252
name: AOX1
has only substance units: false

metaR H2Otly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110011#
name: H2O transport, lysosomal
fast: false
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction

metaR SUBEACTD
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberic acid into cytosol (diffusion)
type: Reaction

metaM hdca e
name: Hexadecanoate (n-C16:0)
type: Species
is: SBO:0000247
is: C00249
has only substance units: false
constant: false
is: HMDB00220
notes: FORMULA: C16H31O2 CHARGE: -1
is: CHEBI:0
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR r0871
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
product: MODEL1310110011#
name: Diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409 NOTES:

metaR FAOXC101C102m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

metaM hco3 c
is: C00288
is: HMDB00595
name: Bicarbonate
constant: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: CHEBI:17544
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0

metaR DM fol
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

metaR AG13T12g
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000176
reactant: MODEL1310110011#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
reversible: false
type: Reaction
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_fdadb2b3_2e87_406c_88ac_b88119f9a303
has only substance units: false
is encoded by: hsa:8659
boundary condition: true
is: SBO:0000252
constant: false
type: Species
name: ALDH4A1
initial concentration: NaN
initial amount: NaN

metaR ODECOAtx
is described by: ECO:0000000
fast: false
type: Reaction
name: fatty acid intracellular transport
reversible: true
reactant: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaM prostgh2 c
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: HMDB01381
name: prostaglandin H2(1-)
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:57405
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR r1671
reactant: MODEL1310110011#
product: MODEL1310110011#
type: Reaction
reversible: true
is: SBO:0000185
modifier: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#
fast: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR AICARte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110011#
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
reversible: true
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
type: Reaction
is described by: ECO:0000134
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_dd818ca2_f105_4acd_bb4e_3516f62207d7
boundary condition: true
is: O95470
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:8879
name: SGPL1

metaM pan4p e
has only substance units: false
initial concentration: 1.0
name: Pantetheine 4'-phosphate
is: CHEBI:47942
boundary condition: false
type: Species
is: HMDB01416
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C11H21N2O7PS CHARGE: -2
constant: false
is: C01134

metaR FACOAL184
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110011#
product: MODEL1310110011#
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110011#
name: fatty-acid--CoA ligase
is described by: ECO:0000000
kinetic law: MODEL1310110011#
fast: false

metaR OCTAt
reactant: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
is: SBO:0000185
type: Reaction
name: Octanoate transport via diffusion
is described by: ECO:0000000
product: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false

metaR ASPPROASCT1
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
name: aspartate intake by system ASCT-1 transporter
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110011#
is described by: ECO:0000134
product: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000185

metaM 2dr5p c
boundary condition: false
name: 2-deoxy-D-ribose 5-phosphate(2-)
is: CHEBI:57651
initial concentration: 1.0
is: HMDB01031
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673

metaR EX 3ttetddcoacrn
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy trans5,8tetradecadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_3e4dfafc_f9a2_4bec_a72d_cc11f614a7eb
has only substance units: false
is encoded by: hsa:55650
is: SBO:0000252
name: PIGV
initial concentration: NaN
is: Q9NUD9
boundary condition: true
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_23c0ef63_afc4_4777_98e3_90f2e1a8f02f
constant: false
is: SBO:0000297
has only substance units: false
is encoded by: hsa:84720
name: PIGF:PIGO
initial amount: NaN
is encoded by: hsa:5281
has part: Q6IB04
type: Species
boundary condition: true
initial concentration: NaN

metaR r0560
type: Reaction
product: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
kinetic law: MODEL1310110011#
reversible: false
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
is described by: ECO:0000000
is: SBO:0000176
fast: false

metaR r1670
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110011#
is described by: ECO:0000000
product: MODEL1310110011#
reversible: true
is: SBO:0000185
fast: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110011#
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_518aa8a6_b480_4b8a_8075_e91794786f89
has only substance units: false
initial amount: NaN
is encoded by: hsa:8560
type: Species
is: O15121
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: DEGS1

metaR C161OHc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecenoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_5da463c0_af4d_493d_b308_278004a27768
type: Species
initial concentration: NaN
boundary condition: true
name: ALDOB
initial amount: NaN
is: P05062
has only substance units: false
is encoded by: hsa:229
is: SBO:0000252
constant: false

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_8a90c6e1_d6b8_4416_a516_d04e7ec970ab
boundary condition: true
constant: false
is: P04746
type: Species
has only substance units: false
is encoded by: hsa:279
is: SBO:0000252
name: AMY2A
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_84f6ebb0_7b90_42d5_b1e2_14ebbda4b77f
constant: false
initial amount: NaN
name: GPX1
is encoded by: hsa:2876
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM dcholcoa r
is: HMDB06292
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:28701
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: SBO:0000247
name: chenodeoxycholoyl coenzyme a
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_f9a237c8_4fca_4ad3_bb8f_09b6c845b7e3
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:51227
name: PIGP

metaM xoltriol c
boundary condition: false
is: HMDB01457
type: Species
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
is: CHEBI:16496
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM chtn e
notes: FORMULA: C24H41N3O16 CHARGE: 0 INCHI: InChI=1S/C24H41N3O16/c1-7(31)25-13-18(36)20(11(5-29)39-22(13)38)42-24-15(27-9(3)33)19(37)21(12(6-30)41-24)43-23-14(26-8(2)32)17(35)16(34)10(4-28)40-23/h10-24,28-30,34-38H,4-6H2,1-3H3,(H,25,31)(H,26,32)(H,27,33)/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+,24+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02118
constant: false
name: chitin
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB03362
is: SBO:0000247
is: CHEBI:17029
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_1e5f7b03_c86d_4fb2_937d_790ce2695e0f
boundary condition: true
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is: O00754
initial amount: NaN
name: MAN2B1
is encoded by: hsa:4125

metaR TETPENT6t
name: fatty acid transport via diffusion
is described by: ECO:0000000
reactant: MODEL1310110011#
type: Reaction
is: SBO:0000185
product: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true

metaR P5CDm
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reversible: false
is version of: http://identifiers.org/ec-code/1.5.1.12
reactant: MODEL1310110011#
fast: false
type: Reaction
modifier: MODEL1310110011#
is: SBO:0000176

metaR RE3520E
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
name: RE3520
product: MODEL1310110011#
reversible: true
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000176
reactant: MODEL1310110011#
type: Reaction
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.11.1.9

http://identifiers.org/biomodels.db/MODEL1310110011#_4a996181_63a7_4635_990f_3f6cc6ecdfdb
has part: Q02153
is encoded by: hsa:2977
name: GUCY1A2:GUCY1B3
initial concentration: NaN
has part: P33402
is encoded by: hsa:2983
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000297
boundary condition: true

metaM 3docopencoa m
name: 3,7,10,13,16-docosapentenoylcoa
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB06294
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false

metaR FAOXC160
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
kinetic law: MODEL1310110011#
is described by: ECO:0000269
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
reactant: MODEL1310110011#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110011#_2bebaa2a_e04b_49a4_aebd_f732d34ffca0
type: Species
is encoded by: hsa:7083
initial concentration: NaN
initial amount: NaN
name: TK1
constant: false
is: P04183
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM ctp e
is: CHEBI:37563
has only substance units: false
is: HMDB00082
constant: false
boundary condition: false
name: CTP(4-)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial concentration: 1.0
type: Species

metaM c16dc c
initial concentration: 1.0
is: SBO:0000247
is: HMDB00712
constant: false
type: Species
boundary condition: false
notes: FORMULA: C23H42NO6 CHARGE: -1
name: Hexadecanedioic acid mono-L-carnitine ester
initial amount: NaN
has only substance units: false

metaM HC02207 c
boundary condition: false
initial amount: NaN
name: prostaglandin-c2
is: SBO:0000247
is: CHEBI:27555
has only substance units: false
constant: false
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
initial concentration: 1.0

metaM CE1944 c
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
name: 1-pyrrolinium
is: CHEBI:36781
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_dfbf55aa_68c9_46fe_9f6d_8b3b4bb2d121
initial amount: NaN
name: NDUFB6
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:4712
type: Species
constant: false
initial concentration: NaN
is: O95139

metaM thmmp m
type: Species
is: CHEBI:37575
boundary condition: false
is: HMDB02666
initial concentration: 1.0
name: thiamine(1+) monophosphate(2-)
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C12H16N4O4PS CHARGE: -1 INCHI: InChI=1S/C12H17N4O4PS/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19)/p-1 EHMN_ABBREVIATION: C01081

metaR HMGCOAtx
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110011#
is: SBO:0000185
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport

metaM gtp e
has only substance units: false
is: CHEBI:37565
is: HMDB01273
constant: false
name: GTP(4-)
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_f919a22b_9f47_43f9_a3f0_45409bb07cf2
constant: false
is encoded by: hsa:2348
name: FOLR1
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_06796026_d203_414b_b104_a505eceef46d
is: SBO:0000252
constant: false
is: P00918
is encoded by: hsa:760
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: CA2
initial concentration: NaN

metaR TRPt
reactant: MODEL1310110011#
name: L-tryptophan transport
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110011#
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
fast: false
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_4dd50815_b74d_47eb_a16e_47fff0b35707
is encoded by: hsa:10786
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: O00476
initial concentration: NaN
name: SLC17A3

http://identifiers.org/biomodels.db/MODEL1310110011#_e98236b2_5d2c_4257_bd7a_6110eca1b676
has only substance units: false
boundary condition: true
is: P28330
name: ACADL
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:33

metaM dlnlcgcoa c
constant: false
is: SBO:0000247
boundary condition: false
name: dihomo-gamma-linolenyl coenzyme A
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:27979
type: Species

metaM leu L e
initial concentration: 1.0
constant: false
is: HMDB00687
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:15603
name: L-leucine

http://identifiers.org/biomodels.db/MODEL1310110011#_78edde6b_e1ed_4f34_948f_e36264a4b2d2
is encoded by: hsa:285973
type: Species
is: Q674R7
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
name: ATG9B

metaM tmndnccoa c
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
name: timnodonyl coenzyme A
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
is: HMDB06514
constant: false

metaR ACOAD9m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial
reactant: MODEL1310110011#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
fast: false
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
type: Reaction

metaM gtp c
is: CHEBI:37565
boundary condition: false
is: HMDB01273
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
constant: false
initial concentration: 1.0
is: C00044
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
name: GTP

metaR AHCYStr
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
fast: false
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
name: S-Adenosyl-L-homocysteine intracellular diffusion
is described by: ECO:0000000

metaR GLUtr
product: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, needed to transport glu-L out of ER in conversion of leuktrC4-> leuktrD4 NJ
reactant: MODEL1310110011#
type: Reaction
reversible: true
name: intracellular transport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_3313ccba_c7ae_407f_9edf_9d94a31575c4
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is: Q8N3E9
initial amount: NaN
has only substance units: false
boundary condition: true
name: PLCD3
is encoded by: hsa:113026

metaM adrn e
constant: false
has only substance units: false
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
is: CHEBI:53487
initial amount: NaN
type: Species
is: SBO:0000247
name: adrenic acid
initial concentration: 1.0
is: HMDB02226
boundary condition: false

metaR CYTK13n
type: Reaction
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
product: MODEL1310110011#
reactant: MODEL1310110011#
modifier: MODEL1310110011#
name: cytidylate kinase (dCMP,dATP),nuclear
kinetic law: MODEL1310110011#
is: SBO:0000176

metaM ksi pre7 g
type: Species
is: SBO:0000247
is: C00130
initial amount: NaN
initial concentration: 1.0
constant: false
name: keratan sulfate I biosynthesis, precursor 7
is: HMDB00175
has only substance units: false
is: CHEBI:58053
notes: FORMULA: C115H187N8O85SX CHARGE: -2
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_80577c26_e192_4113_924e_13c8533c3622
constant: false
name: AK5
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q9Y6K8
is encoded by: hsa:26289
initial concentration: NaN

metaR EX 3hdececrn
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecenoyl carnitine
type: Reaction

metaM leu L c
is: HMDB00687
name: L-leucine
is: CHEBI:15603
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_fc260172_ad23_46ca_ad05_027164ea4333
boundary condition: true
name: SLC25A21
constant: false
type: Species
is encoded by: hsa:89874
initial concentration: NaN
is: SBO:0000252
is: G3V4L5
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_1790ff47_cfc4_49ed_afe5_65875758c8f1
is: Q92947
is encoded by: hsa:2639
constant: false
has only substance units: false
initial amount: NaN
name: GCDH
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN

metaM adrn c
constant: false
is: HMDB02226
is: CHEBI:53487
boundary condition: false
type: Species
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
is: SBO:0000247
has only substance units: false
name: adrenic acid
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_a2faa054_38af_482c_a83c_22258e521c1d
has only substance units: false
is: Q8NFW8
boundary condition: true
is encoded by: hsa:55907
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: CMAS
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_ebf50e23_e711_4079_9141_a82aa059438e
is encoded by: hsa:51227
name: PIGP
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false

metaR CYTK2n
name: cytidylate kinase (dCMP),nuclear
is: SBO:0000176
type: Reaction
product: MODEL1310110011#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
modifier: MODEL1310110011#
reversible: true

metaM ksii core2 pre7 g
notes: FORMULA: C67H108N5O51SX CHARGE: -2
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 7
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:58053
type: Species
is: C00130
is: HMDB00175

metaR EX c6dc
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for adipoyl carnitine
type: Reaction

metaR GLYPHEHYc
kinetic law: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
fast: false
name: hydrolysis of glycylphenylalanine
reactant: MODEL1310110011#
reversible: true
product: MODEL1310110011#
is: SBO:0000176
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110011#_5b7bf9f7_31b2_4214_b143_ac5528aa1489
is: P52824
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: DGKQ
is encoded by: hsa:1609
initial concentration: NaN
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_dfc1cb71_110b_47f7_bb7b_73084f657215
name: SLC5A9
initial concentration: NaN
has only substance units: false
boundary condition: true
is: E9PAK4
is encoded by: hsa:200010
initial amount: NaN
constant: false
is: SBO:0000252
type: Species

metaM HC02121 c
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
initial concentration: 1.0
constant: false
is: CHEBI:58758
name: S-(hydroxymethyl)glutathione(1-)

metaM xu1p D c
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h3,5-7,9H,1-2H2,(H2,10,11,12)/t3-,5-/m1/s1
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
name: D-Xylulose 1-phosphate
constant: false
initial amount: NaN
type: Species
is: HMDB06534

metaM c16dc e
is: HMDB00712
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C23H42NO6 CHARGE: -1
name: Hexadecanedioic acid mono-L-carnitine ester

metaR RDH3a
name: retinol dehydrogenase (11-cis,NADPH)
is described by: ECO:0000269
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.300
modifier: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.1.105
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110011#_43edab61_bdff_425b_a9c1_40eddd21caa6
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AF080579
boundary condition: true
type: Species
name: _AF080579_1_c
initial concentration: NaN
constant: false

metaM mescon m
is: CHEBI:36986
constant: false
name: Mesaconate
is: HMDB00749
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+

http://identifiers.org/biomodels.db/MODEL1310110011#_87ef6c98_5e4c_43e3_9f8d_83e90436cc78
boundary condition: true
is encoded by: hsa:57171
has only substance units: false
is: SBO:0000252
is: Q86YN1
name: DOLPP1
constant: false
type: Species
initial concentration: NaN
initial amount: NaN

metaR VACCCPT2
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
is described by: ECO:0000000
product: MODEL1310110011#
kinetic law: MODEL1310110011#
name: carnitine transferase
type: Reaction
modifier: MODEL1310110011#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110011#

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaR r2088
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110011#
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
product: MODEL1310110011#
is: SBO:0000185
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_09dc2648_0ec5_426e_bc40_212563ccb6b4
has only substance units: false
name: PDE9A
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5152
constant: false
is: SBO:0000252
type: Species
boundary condition: true

metaR r1953
reactant: MODEL1310110011#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
reversible: false
modifier: MODEL1310110011#
product: MODEL1310110011#
fast: false
is described by: ECO:0000000

metaM ksi pre28 g
is: HMDB00175
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 28
has only substance units: false
constant: false
is: C00130
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:58053
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_f8b6a710_df74_4b27_bbf1_867727fe3909
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:9056
has only substance units: false
name: SLC7A7
is: Q9UM01
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM chito2pdol L c
constant: false
type: Species
initial amount: NaN
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human liver homolog
is: HMDB01196
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C1240H2028N20O170P20 CHARGE: -20 INCHI: InChI=1S/C41H72N2O17P2/c1-25(2)13-9-14-26(3)15-10-16-27(4)17-11-18-28(5)19-12-20-29(6)21-22-55-61(51,52)60-62(53,54)59-41-35(43-31(8)47)38(50)39(33(24-45)57-41)58-40-34(42-30(7)46)37(49)36(48)32(23-44)56-40/h13,15,17,19,29,32-41,44-45,48-50H,9-12,14,16,18,20-24H2,1-8H3,(H,42,46)(H,43,47)(H,51,52)(H,53,54)/b26-15+,27-17+,28-19-/t29?,32-,33-,34-,35-,36-,37-,38-,39-,40+,41-/m1/s1
is: CHEBI:12427
boundary condition: false

metaM omhpal r
type: Species
notes: FORMULA: C16H30O3 CHARGE: -1
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
name: w-hydroxypalmiticacid
boundary condition: false
initial amount: NaN
is: HMDB06294

metaR VACCCPT1
product: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110011#
is described by: ECO:0000000
reversible: false
type: Reaction
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110011#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false

metaM ade e
has only substance units: false
constant: false
is: CHEBI:16708
initial concentration: 1.0
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
name: adenine
is: HMDB00034

metaR r2089
reactant: MODEL1310110011#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
type: Reaction
product: MODEL1310110011#
modifier: MODEL1310110011#

metaR ADK1
kinetic law: MODEL1310110011#
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110011#
reversible: true
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110011#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.3
name: adenylate kinase

metaR C6CRNe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexanoyl carnitine into the extra cellular fluid
type: Reaction

metaR NOt
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
reactant: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110011#
reversible: true
name: NO transport (diffusion)

metaR AG13T5g
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110011#
product: MODEL1310110011#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaR EX prgstrn LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Progesterone exchange
type: Reaction

metaM ctp n
boundary condition: false
is: CHEBI:37563
constant: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
name: CTP(4-)
is: HMDB00082
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247

metaM thmmp c
has only substance units: false
initial amount: NaN
constant: false
is: HMDB02666
is: CHEBI:37575
type: Species
boundary condition: false
name: Thiamin monophosphate
is: SBO:0000247
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
is: C01081
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_f9145712_bc0c_455b_b132_301ccf940ba6
is encoded by: hsa:27115
is: Q9NP56
boundary condition: true
name: PDE7B
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
initial amount: NaN

metaR LNLNCACPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
modifier: MODEL1310110011#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110011#
reversible: false
type: Reaction
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine O-palmitoyltransferase
product: MODEL1310110011#

metaR FACOAL260
product: MODEL1310110011#
reversible: true
type: Reaction
kinetic law: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:cytoplasmic version -NJ
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase (n-C26:0)
is: SBO:0000176
reactant: MODEL1310110011#
fast: false

metaR r2086
reactant: MODEL1310110011#
modifier: MODEL1310110011#
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
kinetic law: MODEL1310110011#
type: Reaction
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

metaR r0196
product: MODEL1310110011#
reversible: true
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110011#
is: SBO:0000176
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
type: Reaction
fast: false
is described by: ECO:0000000

metaM 4abut n
notes: FORMULA: C4H9NO2 CHARGE: 0
is: C00334
initial amount: NaN
type: Species
name: 4-Aminobutanoate
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00112

http://identifiers.org/biomodels.db/MODEL1310110011#_bd8affe5_bde4_42e0_bc50_5f14dc7484e6
has only substance units: false
type: Species
is: SBO:0000252
name: _AA021081_1_r
boundary condition: true
constant: false
is encoded by: hsa:AA021081
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_b6f5e929_d74f_47a1_a4e2_66f3f5bdd902
boundary condition: true
name: PRDX3
is: E9PH29
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:10935

metaM gtp n
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
type: Species
initial amount: NaN
name: GTP(4-)
is: HMDB01273
is: CHEBI:37565

metaR LNELDCCRNt
reactant: MODEL1310110011#
reversible: false
product: MODEL1310110011#
modifier: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: transport into the mitochondria (carnitine)
fast: false
is: SBO:0000185

metaM leu L m
constant: false
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
type: Species
initial amount: NaN
is: CHEBI:15603
is: HMDB00687
name: L-leucine
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_dbef9b13_482c_4c30_b014_64268d99a933
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: PLCB4
initial concentration: NaN
is: Q15147
constant: false
is encoded by: hsa:5332

metaR r0002
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110011#
is described by: ECO:0000000
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
name: Active transport
fast: false

metaM xoltriol m
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
has only substance units: false
is: HMDB01457
is: CHEBI:16496
boundary condition: false
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
type: Species

metaR Htg
kinetic law: MODEL1310110011#
type: Reaction
product: MODEL1310110011#
name: proton diffusion (Golgi)
reactant: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR FACOAL80i
name: fatty-acid--CoA ligase (octanoate)
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
modifier: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000269
reversible: false

metaR r2087
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110011#
type: Reaction
reversible: true

metaM 3ivcoa m
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
boundary condition: false
is: SBO:0000247
is: C05998
initial concentration: 1.0
type: Species
name: 3-hydroxyisovalerylcoa
constant: false
initial amount: NaN
has only substance units: false
is: HMDB06870
is: http://identifiers.org/pubchem.compound/11966188

metaM 4abut m
constant: false
name: 4-Aminobutanoate
boundary condition: false
initial concentration: 1.0
is: CHEBI:16865
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
is: HMDB00112
initial amount: NaN
type: Species
is: C00334
is: SBO:0000247
has only substance units: false

metaR FAOXC80
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110011#
is described by: ECO:0000269
name: Beta oxidation of med/long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
modifier: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
product: MODEL1310110011#

metaR LNLNCACPT2
product: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110011#
modifier: MODEL1310110011#
reversible: false
is described by: ECO:0000000

metaR LNLNCAt
reversible: true
is: SBO:0000185
name: fatty acid transport via diffusion
fast: false
type: Reaction
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110011#
reactant: MODEL1310110011#

metaR RE3004M
kinetic law: MODEL1310110011#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE3004
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110011#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM 4hbzcoa m
is: HMDB06467
initial concentration: 1.0
notes: FORMULA: C28H36N7O18P3S CHARGE: -4 INCHI: InChI=1/C28H40N7O18P3S/c1-28(2,22(39)25(40)31-8-7-18(37)30-9-10-57-27(41)15-3-5-16(36)6-4-15)12-50-56(47,48)53-55(45,46)49-11-17-21(52-54(42,43)44)20(38)26(51-17)35-14-34-19-23(29)32-13-33-24(19)35/h3-6,13-14,17,20-22,26,36,38-39H,7-12H2,1-2H3,(H,30,37)(H,31,40)(H,45,46)(H,47,48)(H2,29,32,33)(H2,42,43,44)/t17-,20?,21-,22+,26-/m1/s1
name: 4-hydroxybenoyl-CoA
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_71e2918c_9e2e_4897_b9a3_12fe6ee44a53
is encoded by: hsa:1808
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is: B4DR31
has only substance units: false
boundary condition: true
name: DPYSL2
constant: false

metaR r2084
modifier: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
product: MODEL1310110011#
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_7e99e1cf_aa10_4a23_87ad_7b548343d302
name: IDH1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3417
is: O75874
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true

metaR HIVCRNe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-isovaleryl carnitine into extra cellular space
type: Reaction

metaR G14T6g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110011#
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176

metaM leuktrC4 c
type: Species
initial amount: NaN
is: HMDB01198
has only substance units: false
is: SBO:0000247
name: leukotriene C4(2-)
initial concentration: 1.0
boundary condition: false
is: CHEBI:57973
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
constant: false

metaR NCKt
modifier: MODEL1310110011#
is described by: ECO:0000269
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
is: SBO:0000185
type: Reaction
reversible: true
fast: false
name: Na+/Ca2+-K+ exchange
kinetic law: MODEL1310110011#
product: MODEL1310110011#

metaM tetpent6 e
is: SBO:0000247
constant: false
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
boundary condition: false
initial concentration: 1.0
name: tetracosapentaenoic acid, n-6
initial amount: NaN
has only substance units: false
is: HMDB06322
type: Species

metaR r0009
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
kinetic law: MODEL1310110011#
is described by: ECO:0000000
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.1
reactant: MODEL1310110011#
product: MODEL1310110011#
modifier: MODEL1310110011#
type: Reaction
is: SBO:0000176

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaR r2085
fast: false
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110011#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110011#

metaR r0193
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110011#
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
fast: false
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_2043421c_e3af_49f8_95ab_838c9bfdc873
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q15735
constant: false
type: Species
name: INPP5J
is encoded by: hsa:27124
initial concentration: NaN
is: SBO:0000252

metaR GLYCtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
product: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
is described by: ECO:0000000
name: glycerol transport
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110011#_9903d16d_9611_4475_8574_fc1f0035bb82
boundary condition: true
has only substance units: false
constant: false
name: PIGO
is encoded by: hsa:84720
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_70c2cc48_36aa_4c8c_aee1_74e6e1edbe46
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:4710
name: NDUFB4
is: SBO:0000252
boundary condition: true
is: O95168
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_2d128b70_c333_47ad_927f_099e73326f93
initial concentration: NaN
type: Species
constant: false
name: ACOX3
is encoded by: hsa:8310
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: O15254

metaM mev R x
name: (R)-mevalonate
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
is: HMDB00227
constant: false
is: SBO:0000247
is: CHEBI:36464
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species

metaM dgchol c
constant: false
initial amount: NaN
name: glycochenodeoxycholate
boundary condition: false
is: HMDB00637
type: Species
initial concentration: 1.0
is: CHEBI:36252
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
has only substance units: false
is: SBO:0000247

metaM gtp m
initial concentration: 1.0
is: CHEBI:37565
has only substance units: false
name: GTP
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: C00044
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: HMDB01273
type: Species

metaM 1p3h5c m
has only substance units: false
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
is: CHEBI:6151
initial concentration: 1.0
is: HMDB01369
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
boundary condition: false
is: SBO:0000247

metaR G5SADrm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
product: MODEL1310110011#
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaM pail hs n
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
name: 1-phosphatidyl-1D-myo-inositol(1-)
initial concentration: 1.0
is: CHEBI:57880
type: Species
boundary condition: false

metaR SUCCtp
name: succinate transporter, peroxisome
reactant: MODEL1310110011#
product: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_01afd7d0_999a_4f54_b95f_74eb455c892e
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5152
is: SBO:0000252
boundary condition: true
type: Species
name: PDE9A

metaR r2082
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110011#
kinetic law: MODEL1310110011#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110011#
reversible: true
fast: false
reactant: MODEL1310110011#

metaM leuktrC4 e
name: leukotriene C4(2-)
constant: false
initial concentration: 1.0
is: HMDB01198
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: CHEBI:57973
boundary condition: false

metaM tetpent6 c
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
boundary condition: false
name: tetracosapentaenoic acid, n-6
has only substance units: false
initial concentration: 1.0
is: HMDB06322

metaR FRDPtc
reactant: MODEL1310110011#
is described by: ECO:0000000
product: MODEL1310110011#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110011#
name: lipid, flip-flop intracellular transport
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ

http://identifiers.org/biomodels.db/MODEL1310110011#_a3d246e8_1678_41b9_98af_46009fd80a1d
name: COX6B1
is encoded by: hsa:1340
boundary condition: true
initial concentration: NaN
constant: false
is: P14854
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species

metaR SCPx
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
type: Reaction
name: peroxisomal thiolase 2
product: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.176
reversible: false
is described by: ECO:0000269

metaM ade c
type: Species
is: C00147
constant: false
name: Adenine
is: CHEBI:16708
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: HMDB00034
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR PROSTGD2t
fast: false
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
modifier: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction
product: MODEL1310110011#
name: prostaglandin transport via bicarbonate countertransport
reversible: true

metaR 4ABUTtcn
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: Jane D. Carver, W. Allan Walkera , The Journal of Nutritional Biochemistry, Volume 6, Issue 2, February 1995, Pages 58?72. NOTES:added during gap-filling, required for GABA role in cell proliferation.
name: transport of GABA
reversible: false
type: Reaction
product: MODEL1310110011#
fast: false
is described by: ECO:0000134
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_210bc57a_c4d1_4cf7_a9a0_a31539c30ca8
is: SBO:0000252
is: P11169
initial amount: NaN
name: SLC2A3
initial concentration: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:6515

metaM CE0849 m
has only substance units: false
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5041
name: cis,cis-palmito-7,10-dienoyl-CoA
is: SBO:0000247
type: Species
is: C01936

metaR r0191
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
type: Reaction
fast: false
reversible: false
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
is described by: ECO:0000000
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.2.1.24
product: MODEL1310110011#
is: SBO:0000176

metaR r2083
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110011#
reversible: true
product: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_b3f3b0ce_d318_44be_be56_ece376d7da02
name: PDE8A
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:5151
initial amount: NaN
has only substance units: false
is: O60658
boundary condition: true

metaM tethex3coa c
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
constant: false
name: tetracosahexaenoyl coenzyme A
is: HMDB06243
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
initial amount: NaN
is: C16168
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205478

http://identifiers.org/biomodels.db/MODEL1310110011#_25459bd9_7a54_4c73_8e8d_67867bc85656
name: _AI222095_1_e
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI222095
type: Species
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_08a72b03_6394_48a3_9854_7d9ff71e8f1b
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is: P49902
constant: false
name: NT5C2
is: SBO:0000252
is encoded by: hsa:22978
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_5289c3e2_a8e4_4f91_b13f_aac7f458bd9e
boundary condition: true
type: Species
is: SBO:0000252
name: ACAT1
is: P24752
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:38
constant: false
has only substance units: false

metaR GGH 5DHFe
modifier: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (5DHF), extracellular
reversible: false
fast: false
product: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110011#_8f3f5437_83ca_45bc_b825_2f6409d622be
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: _F23536_1_m
is encoded by: hsa:F23536
constant: false
is: SBO:0000252

metaM amet r
notes: FORMULA: C15H23N6O5S CHARGE: 1 INCHI: InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: SBO:0000247
constant: false
type: Species
is: CHEBI:15414
name: S-adenosyl-L-methionine
initial concentration: 1.0
has only substance units: false
is: HMDB01185
boundary condition: false
initial amount: NaN

metaR sink tetdec2coa LPAREN c RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDEC2COASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_a068919a_52c1_49c2_90cd_66f7134f6a47
initial concentration: NaN
is: SBO:0000252
name: LDHAL6B
boundary condition: true
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:92483
is: Q9BYZ2
has only substance units: false

metaR URIt5le
fast: false
type: Reaction
reactant: MODEL1310110011#
is: SBO:0000185
name: uridine transport in via sodium symport (1:2)
is described by: ECO:0000134
reversible: false
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110011#
product: MODEL1310110011#
modifier: MODEL1310110011#

metaR GLNCYSNaEx
type: Reaction
is: SBO:0000185
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)
reactant: MODEL1310110011#
fast: false
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#

metaR AHCYSte
name: Transport of S-adenosyl-L-homocysteine
reactant: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110011#
type: Reaction
product: MODEL1310110011#
fast: false

metaM leuktrF4 e
has only substance units: false
initial amount: NaN
is: CHEBI:27491
is: HMDB06465
name: leukotriene F4
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
constant: false
is: SBO:0000247
type: Species

metaM gthox c
type: Species
is: C00127
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
name: Oxidized glutathione
is: HMDB03337
is: CHEBI:58297

metaR r2093
product: MODEL1310110011#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#

metaM ksi pre32 g
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
has only substance units: false
initial amount: NaN
is: CHEBI:28067
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 32
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_e6ae0560_2cbf_441c_9a89_60923223913c
initial concentration: NaN
name: SLC24A4
is encoded by: hsa:123041
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false

metaM dhf c
is: CHEBI:57451
boundary condition: false
is: C00415
name: 7,8-Dihydrofolate
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: HMDB01056

metaM pe hs c
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
name: phosphatidylethanolamine
initial amount: NaN
is: CHEBI:16038
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_59006018_0885_4cb1_b969_a8eb89c3d0b0
boundary condition: true
initial concentration: NaN
constant: false
is: Q86YU0
type: Species
name: CA7
is encoded by: hsa:766
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM gthox e
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB03337
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:58297

http://identifiers.org/biomodels.db/MODEL1310110011#_4f442eb7_184e_4610_acba_b84938f6d698
is: O75438
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4707
name: NDUFB1
constant: false

metaM q10h2 e
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/6504740
has only substance units: false
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
name: Ubiquinol-10
initial amount: NaN
is: HMDB13111
is: SBO:0000247
type: Species
constant: false

metaR PMEVKx
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.4.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
type: Reaction
product: MODEL1310110011#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.4.2
kinetic law: MODEL1310110011#
name: phosphomevalonate kinase
is described by: ECO:0000134
reactant: MODEL1310110011#
fast: false
is: SBO:0000176

metaR r2092
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000000
product: MODEL1310110011#
modifier: MODEL1310110011#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110011#_5ee2a0ce_bdc5_4654_b29d_bddf9d81f60f
type: Species
is: P13686
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:54
boundary condition: true
name: ACP5
has only substance units: false
initial amount: NaN

metaR C160CPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110011#
fast: false
name: C160 transport into the mitochondria
kinetic law: MODEL1310110011#
reversible: false
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
product: MODEL1310110011#
is: SBO:0000176

metaR OXAHCOtex
is described by: ECO:0000304
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (1836.1) or (10861.1) or (10861.3) or (10861.2) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reversible: false
fast: false
type: Reaction
is: SBO:0000185
name: oxalate transport via bicarbonate countertransport
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
modifier: MODEL1310110011#

metaR EX 3tdcrn
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-tetradecanoyl carnitine
type: Reaction

metaM hpdcacoa m
boundary condition: false
is: SBO:0000247
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
is: HMDB06497
type: Species
name: heptadecanoyl coa
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaM m2emgacpail hs r
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
boundary condition: false
initial amount: NaN
is: C00080
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:24636
type: Species
constant: false

metaR CLFORtex
kinetic law: MODEL1310110011#
is described by: ECO:0000304
reactant: MODEL1310110011#
type: Reaction
reversible: false
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
modifier: MODEL1310110011#
is: SBO:0000185
fast: false
name: chloride transport via formate countertransport

metaM HC01223 m
boundary condition: false
has only substance units: false
is: CHEBI:57340
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_58972e66_9449_4d81_90b5_278137dc92bf
name: PDE3B
type: Species
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5140
is: Q13370
is: SBO:0000252

metaR r0464
type: Reaction
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
reactant: MODEL1310110011#
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000176

metaM 4abut e
constant: false
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0
name: 4-Aminobutanoate
is: C00334
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:3628
boundary condition: false
initial amount: NaN
is: HMDB00112
type: Species

metaM HC01408 m
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
type: Species
name: 3-Oxohexanoyl-CoA
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:27648

http://identifiers.org/biomodels.db/MODEL1310110011#_6832c521_e40f_413c_b038_a2b76ae56d4e
is: B3KT86
has only substance units: false
is: SBO:0000252
name: ADCY3
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:109
initial concentration: NaN
constant: false

metaR r2091
type: Reaction
kinetic law: MODEL1310110011#
fast: false
modifier: MODEL1310110011#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110011#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110011#

metaM dhf e
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: dihydrofolate(2-)
constant: false
type: Species
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial concentration: 1.0
has only substance units: false
is: HMDB01056
is: CHEBI:57451

metaM leuktrF4 c
is: HMDB06465
boundary condition: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
initial amount: NaN
name: leukotriene F4
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:27491

metaR C160CPT1
name: production of Palmitoylcarnitine
product: MODEL1310110011#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:
modifier: MODEL1310110011#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110011#
is: SBO:0000176
kinetic law: MODEL1310110011#
reversible: false

metaM btcoa c
initial concentration: 1.0
constant: false
is: CHEBI:57371
has only substance units: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
initial amount: NaN
is: HMDB01088
type: Species
is: SBO:0000247
name: Butanoyl-CoA
is: C00136
boundary condition: false

metaR GGH 10FTHF7GLUe
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
modifier: MODEL1310110011#
reactant: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110011#_6a8c3cf7_0f40_4bba_84e4_7246589d1b9c
is encoded by: hsa:2954
initial amount: NaN
type: Species
initial concentration: NaN
name: GSTZ1
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false

metaR RE2349C
kinetic law: MODEL1310110011#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.64
is described by: ECO:0000000
reactant: MODEL1310110011#
modifier: MODEL1310110011#
name: RE2349
product: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_87677848_a7ac_4ae8_b147_3adc5c500236
has only substance units: false
is: Q7Z7B1
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:284098
type: Species
boundary condition: true
name: PIGW

metaR AHCYStd
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
fast: false
type: Reaction
name: diffusion of S-Adenosyl-L-homocysteine
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000134
reversible: true

metaR r0570
type: Reaction
reversible: true
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.3.2
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
is: SBO:0000176
product: MODEL1310110011#
modifier: MODEL1310110011#

metaR FAOXC12DCc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: formation of dodecanedioyl carnitine
type: Reaction

metaR SERGLNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
fast: false
reversible: false
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
name: L-serine/L-glutamine Na-dependent exchange (Ser-L in)
reactant: MODEL1310110011#
is: SBO:0000185
product: MODEL1310110011#
type: Reaction

metaM tmndnccoa m
name: timnodonyl coenzyme A
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
initial concentration: 1.0
is: HMDB06514

metaR r2090
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110011#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110011#
modifier: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#
reversible: true

metaM q10h2 c
constant: false
boundary condition: false
has only substance units: false
name: Ubiquinol-10
is: http://identifiers.org/pubchem.compound/6504740
initial amount: NaN
is: HMDB13111
is: SBO:0000247
type: Species
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
initial concentration: 1.0

metaM tetdecdicoa m
name: 5,8-tetradecadienoylcoa
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB02288
type: Species
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_9753b2d0_7ebd_45d5_8de6_64f33db0887b
constant: false
name: PHGDH
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is: O43175
is encoded by: hsa:26227
initial concentration: NaN

metaM ac m
name: acetate
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: HMDB00042
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:30089
initial amount: NaN

metaR r2199
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110011#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
kinetic law: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
is described by: ECO:0000000
type: Reaction

metaR sink dd2coa LPAREN c RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: DD2COASINK
type: Reaction

metaR DESAT20 2
is: SBO:0000176
reactant: MODEL1310110011#
fast: false
product: MODEL1310110011#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110011#
name: fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)
modifier: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_a53158e0_62a2_4aee_ad4a_b87f6b66ee94
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:5152
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
name: PDE9A

metaR SCP22x
reactant: MODEL1310110011#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.176
is: SBO:0000185
product: MODEL1310110011#
name: Sterol carrier protein 2
is described by: ECO:0000000
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#

metaR DESAT20 1
fast: false
product: MODEL1310110011#
reversible: false
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#

metaM met L e
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00696
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:16643
name: L-methionine
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075

http://identifiers.org/biomodels.db/MODEL1310110011#_91aabb39_67a1_46b9_859f_7e3316bec1de
constant: false
has only substance units: false
is encoded by: hsa:286016
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: TPI1P2
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_6d7fa1a9_0ec3_4dfa_ae10_1c0d060cb850
boundary condition: true
is: Q9Y2Z9
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:51004
constant: false
initial amount: NaN
name: COQ6

metaR NRVNCt
name: fatty acid transport via diffusion
product: MODEL1310110011#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
type: Reaction
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000000

metaM his L c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
type: Species
boundary condition: false
constant: false
is: CHEBI:15971
initial amount: NaN
is: HMDB00177
is: SBO:0000247
name: L-histidine

metaM glysar c
boundary condition: false
is: http://identifiers.org/pubchem.compound/93131
has only substance units: false
notes: FORMULA: C5H10N2O3 CHARGE: 0
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
name: Glycylsarcosine

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaM 35cgmp c
is: HMDB01314
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
name: 3',5'-cyclic GMP(1-)
is: CHEBI:57746
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_798587f2_6bd7_4f4a_b851_18c413c3393b
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: B7Z3W8
name: SLC6A9
type: Species
is encoded by: hsa:6536
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_e5c7a4cd_3654_43a1_b3cd_221be333c557
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9023
name: CH25H
initial amount: NaN
type: Species
is: O95992
has only substance units: false

metaR HACD9m
modifier: MODEL1310110011#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110011#
is described by: ECO:0000134
kinetic law: MODEL1310110011#
product: MODEL1310110011#
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
reversible: true
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110011#_15b10f05_3cb1_4819_97c8_7f1413a04cf7
has only substance units: false
is: P32321
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:1635
initial amount: NaN
name: DCTD
initial concentration: NaN

metaR PItx
is described by: ECO:0000000
name: Phosphate transporter, peroxisome
reactant: MODEL1310110011#
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false

metaR THRALANaEx
is described by: ECO:0000269
product: MODEL1310110011#
is: SBO:0000185
reactant: MODEL1310110011#
reversible: false
modifier: MODEL1310110011#
type: Reaction
name: L-alanine/L-threonine Na-dependent exchange (Thr-L in)
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_4a3a604c_e674_4df6_8aea_c005b024702d
type: Species
is encoded by: hsa:48
name: ACO1
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is: P21399

metaM retinal cis 9 r
type: Species
is: HMDB01358
is: CHEBI:17898
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
name: all-trans-retinal
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_c3db3384_bac6_47d6_a58a_c25404d7cefa
name: PLCB4
boundary condition: true
constant: false
is encoded by: hsa:5332
has only substance units: false
type: Species
is: E2QRH8
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM ksi pre10 g
initial amount: NaN
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
constant: false
boundary condition: false
type: Species
name: keratan sulfate I biosynthesis, precursor 10
is: C00130
is: CHEBI:58053
is: HMDB00175
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_1cfe9a35_0fd1_42bf_8313_7fa195b8bec0
has only substance units: false
is encoded by: hsa:1347
type: Species
name: COX7A2
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is: H0UI06

http://identifiers.org/biomodels.db/MODEL1310110011#_1e06bc6a_2c88_4f4b_ab9a_8984644f55e0
has only substance units: false
name: PNP
is: P00491
boundary condition: true
is encoded by: hsa:4860
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_b7b6ff16_aeaa_4632_a1fc_46b5571a19fc
initial concentration: NaN
is: O14521
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:6392
boundary condition: true
name: SDHD

http://identifiers.org/biomodels.db/MODEL1310110011#_47bfd19f_be6f_4942_a03b_4f92ae453540
type: Species
initial concentration: NaN
is: SBO:0000252
name: DGKD
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:8527
has only substance units: false
is: Q16760

http://identifiers.org/biomodels.db/MODEL1310110011#_af3ffd2d_1a90_4b96_ac79_b6d4e3b107e7
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:5152
type: Species
name: PDE9A
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_b67c0225_d521_4d54_b586_601f2e55a327
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:10846
name: PDE10A
is: Q9Y233
initial concentration: NaN

metaR BAAT1x
is: SBO:0000176
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.65
name: bile acid Coenzyme A: amino acid N-acyltransferase
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
reversible: false
fast: false

metaR EX c4crn
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for butyryl carnitine
type: Reaction

metaR FAOXC184C163m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C18:4-->C16:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_e8dd9733_dd0c_41e6_a310_460516efdfb5
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
name: _83530_1_c
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:83530

metaM met L c
initial concentration: 1.0
has only substance units: false
is: HMDB00696
constant: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
name: L-methionine
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:16643

metaM pe hs e
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16038
constant: false
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_dc7ce569_de3f_48a0_85fb_068f73dd38e8
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: PDE9A
has only substance units: false
initial amount: NaN
is encoded by: hsa:5152

http://identifiers.org/biomodels.db/MODEL1310110011#_8107e871_8a1a_4e0a_825e_a34e531fa5a1
constant: false
is: P00439
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5053
initial amount: NaN
type: Species
name: PAH
is: SBO:0000252

metaR SARCStm
is described by: ECO:0000000
name: Sarcosine transport (mitochondrial)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
product: MODEL1310110011#
type: Reaction
reversible: false
fast: false
is: SBO:0000185
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#

metaM docohexcoa m
boundary condition: false
has only substance units: false
type: Species
name: 2,4,7,10,13,16-docosahexenoylcoa
is: HMDB06294
is: SBO:0000247
constant: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0

metaM glysar e
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C5H10N2O3 CHARGE: 0
type: Species
initial concentration: 1.0
name: Glycylsarcosine
is: http://identifiers.org/pubchem.compound/93131

metaR HOXG
reversible: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
fast: false
product: MODEL1310110011#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.99.3
type: Reaction
modifier: MODEL1310110011#
reactant: MODEL1310110011#
name: Heme oxygenase 1
kinetic law: MODEL1310110011#

metaR r2194
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110011#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#

metaR DHORD9
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000269
reversible: false
fast: false
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
name: dihydoorotic acid dehydrogenase (quinone10)
is version of: http://identifiers.org/ec-code/1.3.5.2
reactant: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
is: SBO:0000185

metaR UMPK2n
reactant: MODEL1310110011#
is described by: ECO:0000269
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
name: UMP kinase (CTP),nuclear
product: MODEL1310110011#
reversible: true
fast: false
kinetic law: MODEL1310110011#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_a62b5a5c_36b1_433c_a6fb_badede7f2561
is: Q53H96
constant: false
initial concentration: NaN
is encoded by: hsa:65263
type: Species
is: SBO:0000252
name: PYCRL
boundary condition: true
initial amount: NaN
has only substance units: false

metaR r0575
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
kinetic law: MODEL1310110011#
fast: false
is: SBO:0000176
modifier: MODEL1310110011#
reactant: MODEL1310110011#
reversible: true
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.48
type: Reaction

metaR FAOXC150m
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110011#
modifier: MODEL1310110011#
product: MODEL1310110011#
reversible: false
name: Beta oxidation of long chain fatty acid (odd chain)
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110011#

metaM ksi pre5 g
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 5
is: CHEBI:28067
notes: FORMULA: C101H164N7O75SX CHARGE: -2
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_f44017bc_7db4_4dda_8045_c7a5a7a92aff
is: SBO:0000297
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:8803
has part: E5KS60
initial concentration: NaN
type: Species
initial amount: NaN
name: SUCLG1:SUCLA2

metaR r2193
modifier: MODEL1310110011#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction

MODEL1310110011
species: metaM retinol cis 11 c
species: metaM hestratriol e
reaction: metaR HDCAter
reaction: metaR TAURCHAe
reaction: metaR DM T antigen g
reaction: metaR FAOXC226205m
reaction: metaR TPI
reaction: metaR r2096
reaction: metaR EX c8crn
species: metaM dcdp n
reaction: metaR AKR1C42
species: metaM 4izp c
reaction: metaR r2364
species: metaM adpcoa c
species: metaM oaa c
reaction: metaR DM gpi sig er
reaction: metaR r1106
species: metaM didp n
reaction: metaR RE3346C
species: metaM 56dthm c
reaction: metaR r2319
species: metaM CE2418 m
reaction: metaR r2007
species: metaM udp r
species: metaM HC02208 e
species: metaM zymstnl r
reaction: metaR ALADGLNexR
reaction: metaR C161CPT1
species: metaM lthstrl r
species: metaM HC02208 c
species: metaM ala L m
species: metaM 3tetd7ecoacrn e
species: metaM cmpacna g
species: metaM xol7ah2al c
reaction: metaR r1433
reaction: metaR GLNyLATthc
reaction: metaR CYTK12
reaction: metaR HGNTOR
species: metaM homoval m
reaction: metaR EX lac D LPAREN e RPAREN
reaction: metaR r0276
species: metaM 3tetd7ecoacrn c
reaction: metaR C162OHc
species: metaM ura c
reaction: metaR r2113
reaction: metaR MALSO3tm
reaction: metaR r1590
reaction: metaR EX lnlnca LPAREN e RPAREN
species: metaM arg L e
reaction: metaR OCTAt
reaction: metaR NNATn
species: metaM ksi pre15 g
reaction: metaR ADSK
species: metaM 44mzym r
species: metaM msa m
species: metaM xol27oh r
reaction: metaR DGCHOLtx
reaction: metaR PI34P5K
reaction: metaR r0830
species: metaM hdcecrn m
species: metaM ps hs m
reaction: metaR r2534
reaction: metaR GPIDAer
species: metaM dchac e
reaction: metaR DM dgpi prot hs r
reaction: metaR r2511
reaction: metaR SPODMe
reaction: metaR CHSTEROLt3
reaction: metaR GTMLTe
reaction: metaR FAOXC14C14OHm
species: metaM fprica c
reaction: metaR G14T10g
reaction: metaR r1557
species: metaM 3otdcoa m
reaction: metaR ACOAD9m
species: metaM ahcys r
reaction: metaR r1377
reaction: metaR PROD2
reaction: metaR r1656
reaction: metaR CDS

http://identifiers.org/biomodels.db/MODEL1310110011#_2989f4ca_c2bd_41cc_b0c8_b44c46b82693
has only substance units: false
initial amount: NaN
name: PSPH
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P78330
is encoded by: hsa:5723
type: Species

metaM q10h2 m
is: http://identifiers.org/pubchem.compound/6504740
initial amount: NaN
is: HMDB13111
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: Ubiquinol-10
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
has only substance units: false

metaR RE1448N
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110011#
product: MODEL1310110011#
fast: false
reversible: true
kinetic law: MODEL1310110011#
type: Reaction
is: SBO:0000176
name: RE1448

metaR HEXDCRNe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecanoyl carnitine into extra cellular space
type: Reaction

metaR S6T11g
modifier: MODEL1310110011#
product: MODEL1310110011#
fast: false
type: Reaction
reactant: MODEL1310110011#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_6bfd420c_a077_4cc5_b1e1_22e05439d170
type: Species
initial concentration: NaN
is encoded by: hsa:56922
is: SBO:0000252
is: Q96RQ3
has only substance units: false
constant: false
initial amount: NaN
name: MCCC1
boundary condition: true

metaM ksi pre25 g
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 25
initial amount: NaN
constant: false
is: CHEBI:58053
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
is: HMDB00175
type: Species
is: C00130
has only substance units: false

metaR C4CRNCPT2
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of butyryl carnitine in the mitochondrial matrix for final hydrolysis
type: Reaction

metaM pail hs c
type: Species
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
name: 1-phosphatidyl-1D-myo-inositol(1-)
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:57880
is: SBO:0000247

metaR ASNtN1
kinetic law: MODEL1310110011#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is: SBO:0000185
reversible: true
reactant: MODEL1310110011#
name: Asparagine transport (Na, H coupled)
product: MODEL1310110011#
modifier: MODEL1310110011#
is described by: ECO:0000269

metaM arachcrn c
is: HMDB06460
type: Species
constant: false
boundary condition: false
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
initial amount: NaN
name: arachidyl carnitine
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_17c23d77_b719_414b_a45d_b69f56b2f64c
is: SBO:0000252
boundary condition: true
is: Q9UBM1
has only substance units: false
type: Species
is encoded by: hsa:10400
constant: false
name: PEMT
initial amount: NaN
initial concentration: NaN

metaM his L e
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
initial amount: NaN
name: L-histidine
boundary condition: false
has only substance units: false
is: CHEBI:15971
initial concentration: 1.0
is: HMDB00177
is: SBO:0000247
type: Species
constant: false

metaM ac e
is: HMDB00042
initial concentration: 1.0
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: acetate
is: CHEBI:30089
type: Species
has only substance units: false
constant: false

metaR DM gpi sig er
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaM dgtp c
is: SBO:0000247
type: Species
is: C00286
initial amount: NaN
is: HMDB01440
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
name: dGTP
is: CHEBI:16497
has only substance units: false

metaM dhf m
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
name: dihydrofolate(2-)
initial amount: NaN
boundary condition: false
is: HMDB01056
constant: false
type: Species
has only substance units: false
is: CHEBI:57451
initial concentration: 1.0
is: SBO:0000247

metaR r1527
is: SBO:0000185
reversible: false
is described by: ECO:0000000
product: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
modifier: MODEL1310110011#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/4.2.1.1

http://identifiers.org/biomodels.db/MODEL1310110011#_f23f9b02_2a7d_4bd4_a1c0_2bd4d5e428ac
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: Q9BZX2
is encoded by: hsa:7371
initial amount: NaN
constant: false
name: UCK2
is: SBO:0000252

metaM mag hs c
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB12130
constant: false
is: CHEBI:16987
has only substance units: false
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
name: monoacylglycerol 2

metaR OCTDECCACT
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaM cholcoa c
has only substance units: false
name: choloyl-CoA(4-)
initial concentration: 1.0
is: HMDB01374
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
initial amount: NaN
constant: false
is: CHEBI:57373
is: SBO:0000247
type: Species
boundary condition: false

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaR r0578
reversible: true
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
modifier: MODEL1310110011#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.2.27
product: MODEL1310110011#

metaM leuktrC4 r
initial concentration: 1.0
constant: false
is: HMDB01198
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: CHEBI:57973
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
name: leukotriene C4(2-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_2f296142_d0a6_4f7a_b3d5_eba2ad6decb1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI926493
constant: false
boundary condition: true
initial amount: NaN
type: Species
name: _AI926493_1_m
initial concentration: NaN

metaR r2198
modifier: MODEL1310110011#
is: SBO:0000185
product: MODEL1310110011#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#

metaM CE2434 m
initial concentration: 1.0
boundary condition: false
constant: false
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
is: C01936
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5041
type: Species
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434

metaR FAOXC183C163Gm
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

metaR RE2649C
reactant: MODEL1310110011#
product: MODEL1310110011#
type: Reaction
name: RE2649
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.2
reversible: true
kinetic law: MODEL1310110011#

metaM 4hglusa m
initial amount: NaN
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
name: L-4-hydroxyglutamic semialdehyde
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:27809
is: HMDB06556

metaM but e
has only substance units: false
initial amount: NaN
is: CHEBI:17968
initial concentration: 1.0
name: butyrate
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
constant: false
is: SBO:0000247
is: HMDB00039
boundary condition: false
type: Species

metaM 4abut c
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00112
is: CHEBI:3628
constant: false
has only substance units: false
is: C00334
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0
boundary condition: false
name: 4-Aminobutanoate

http://identifiers.org/biomodels.db/MODEL1310110011#_cd0a12e4_5e63_4b26_80a1_d6e61d6bba06
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:9057
has only substance units: false
name: SLC7A6
is: Q92536

metaM his L m
name: L-histidine
has only substance units: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
initial amount: NaN
boundary condition: false
is: CHEBI:15971
initial concentration: 1.0
is: HMDB00177

http://identifiers.org/biomodels.db/MODEL1310110011#_d79ef2a8_f7e8_4258_a019_5d048ab48a2a
boundary condition: true
name: SLC24A4
is: Q8NFF2
type: Species
initial concentration: NaN
is encoded by: hsa:123041
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM eicostetcrn m
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
name: Eicosatetranoyl carnitine
type: Species
is: HMDB01356
boundary condition: false
initial amount: NaN
is: CHEBI:57312

metaR r0860
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
fast: false
modifier: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Utilized transport
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/4.1.2.27
product: MODEL1310110011#
reversible: true

metaM g1m8masn r
initial concentration: 1.0
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C76H127N2O60X CHARGE: 0
constant: false
type: Species
is: C05875
boundary condition: false

metaM dgtp e
is: HMDB01440
initial concentration: 1.0
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: CHEBI:16497
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
name: dGTP

metaR r2197
modifier: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110011#
reversible: true
is: SBO:0000185
product: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r1682
kinetic law: MODEL1310110011#
name: Y+LAT2 Utilized transport
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110011#
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_a7b0f9f9_fce9_4450_a66e_72e5b1f3af5c
initial concentration: NaN
name: HIBCH
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q6NVY1
type: Species
initial amount: NaN
is encoded by: hsa:26275

metaR GLYBtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8443213 NOTES:MM
fast: false
is described by: ECO:0000000
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reversible: true
is: SBO:0000185
type: Reaction
name: Glycine betaine transport via diffusion (mitochondria to cytosol)

metaM mag hs e
initial concentration: 1.0
name: monoacylglycerol 2
boundary condition: false
type: Species
is: HMDB03073
is: CHEBI:32391
has only substance units: false
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
is: SBO:0000247
constant: false
initial amount: NaN

metaM HC02207 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
initial concentration: 1.0
is: CHEBI:27555
has only substance units: false
name: prostaglandin-c2
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
constant: false

metaM ac c
is: CHEBI:30089
has only substance units: false
initial amount: NaN
is: HMDB00042
name: acetate
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033

metaR AG13T13g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
is: SBO:0000176
reversible: false
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#

metaR CYSTA
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
reversible: true
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110011#
fast: false
name: cysteine transaminase
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_7c4146a5_bb83_42c8_9541_485990326eba
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:80025
type: Species
name: PANK2
constant: false
is: Q6P1K9
is: SBO:0000252
initial concentration: NaN

metaM ppcoa x
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: Propanoyl-CoA
is: C00100
is: CHEBI:57392
type: Species
constant: false
boundary condition: false
has only substance units: false
is: HMDB01275
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100

metaR r2196
reactant: MODEL1310110011#
product: MODEL1310110011#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110011#

metaM betald m
is: HMDB01252
constant: false
name: betaine aldehyde
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
is: CHEBI:15710

metaM ctp c
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:37563
is: HMDB00082
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
name: CTP
is: C00063
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063

metaM but c
is: CHEBI:17968
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: HMDB00039
name: butyrate

metaR ABUTD
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
fast: false
reversible: false
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
reactant: MODEL1310110011#
is: SBO:0000176
name: Aminobutyraldehyde dehydrogenase
is described by: ECO:0000269
kinetic law: MODEL1310110011#
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_e4f6bcff_585e_4bb6_9388_6d5cfd5dfd1d
initial concentration: NaN
type: Species
is encoded by: hsa:4716
initial amount: NaN
boundary condition: true
is: A8K761
name: NDUFB10
has only substance units: false
constant: false
is: SBO:0000252

metaR FAOXC226
product: MODEL1310110011#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211

metaR r2195
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
reversible: true
reactant: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185

metaM dcholcoa x
constant: false
is: HMDB06292
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
name: chenodeoxycholoyl coenzyme a
is: CHEBI:28701

metaM omhpal c
is: HMDB06294
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C16H30O3 CHARGE: -1
name: w-hydroxypalmiticacid
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN

metaR DGK1
type: Reaction
name: deoxyguanylate kinase (dGMP:ATP)
is version of: http://identifiers.org/ec-code/2.7.4.8
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000176
reactant: MODEL1310110011#
modifier: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM pe hs m
initial amount: NaN
initial concentration: 1.0
name: phosphatidylethanolamine
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
type: Species
is: CHEBI:16038
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_b4cdb892_4514_4f21_bf4e_3c519cc92a5f
is encoded by: hsa:224
initial amount: NaN
has only substance units: false
name: ALDH3A2
boundary condition: true
is: SBO:0000252
constant: false
type: Species
is: P51648
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_32e5ba01_b4d8_4056_a8ac_cffa2419a7a7
is: SBO:0000252
name: NDUFS3
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:4722
type: Species
is: O75489

metaM dmnoncoa c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: 4,8 dimethylnonanoyl-CoA
has only substance units: false
is: HMDB11604
type: Species
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_d628449c_2ee6_469f_8102_17ed29e0ba9d
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:81031
is: SBO:0000252
initial concentration: NaN
name: SLC2A10
has only substance units: false
constant: false
is: O95528

metaR CH25H
fast: false
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110011#
name: cholesterol 25-hydroxylase
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.14.99.38

metaR ABTD
reactant: MODEL1310110011#
is: SBO:0000176
name: L-arabinitol 4-dehydrogenase
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110011#
fast: false
product: MODEL1310110011#

metaM m3mpdol L c
notes: FORMULA: C1480H2428N20O370P20 CHARGE: -20
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
constant: false
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human liver homolog
is: CHEBI:37632
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_37315f88_b3fe_4e6b_82d0_b287bda4b772
is encoded by: hsa:6898
has only substance units: false
initial concentration: NaN
name: TAT
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
constant: false
is: P17735

metaR UGLT
reactant: MODEL1310110011#
name: UDPglucose--hexose-1-phosphate uridylyltransferase
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110011#
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.7.12
fast: false

metaR FACOAL2042
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110011#
reactant: MODEL1310110011#
product: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
name: fatty-acid--CoA ligase

metaM prostgf2 c
name: prostaglandin F2alpha(1-)
is: CHEBI:57404
is: HMDB01139
boundary condition: false
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_54a4ec97_9c13_475a_89d6_10eca19c29d4
has only substance units: false
initial amount: NaN
name: LDHC
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:3948
is: SBO:0000252
boundary condition: true
is: P07864

metaR SERALANaEx
type: Reaction
product: MODEL1310110011#
reversible: false
name: L-alanine/L-serine Na-dependent exchange (Ser-L in)
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
reactant: MODEL1310110011#

metaM xol25oh r
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
name: 25-hydroxycholesterol
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: HMDB06247
is: CHEBI:42977

metaM hpdca c
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:32366
name: margarate
type: Species
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
is: HMDB02259
initial amount: NaN
boundary condition: false

metaR C50CPT1
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of isovalerylcarnitine
type: Reaction

metaM dopa c
is: HMDB00073
has only substance units: false
name: dopaminium(1+)
is: SBO:0000247
initial amount: NaN
is: CHEBI:59905
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758

metaM chol c
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: CHEBI:15354
initial amount: NaN
constant: false
name: Choline
boundary condition: false
is: HMDB00097
has only substance units: false
initial concentration: 1.0
is: C00114
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_6a447a49_91fb_4772_8fe4_48862e130296
is encoded by: hsa:2639
initial concentration: NaN
boundary condition: true
type: Species
name: GCDH
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN

metaR RE1525M
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
name: RE1525
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110011#
fast: false
type: Reaction
modifier: MODEL1310110011#
reactant: MODEL1310110011#
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR ALAASNNaEx
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110011#
reversible: false
product: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
type: Reaction
kinetic law: MODEL1310110011#
is: SBO:0000185

metaR CSNAT2m
fast: false
kinetic law: MODEL1310110011#
is described by: ECO:0000000
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.7
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
name: carnitine O-aceyltransferase, mitochondrial
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_dbc88ab0_8118_44d6_8256_e4822bf59054
is: SBO:0000252
is: Q9NST1
boundary condition: true
is encoded by: hsa:80339
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
constant: false
name: PNPLA3

metaR B MANNASEly
is: SBO:0000176
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.25
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
name: beta-mannosidase, lysosomal
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_6591e20a_523a_4c6b_b5b0_7a8dcd7374ca
is: Q9H2X9
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: SLC12A5
type: Species
is encoded by: hsa:57468
has only substance units: false

metaR C102CPT1
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decadienoylcarnitine
type: Reaction

metaM 5adtststerones e
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB06278
name: 5alpha-Dihydrotestosterone sulfate
constant: false
is: SBO:0000247

metaM 4hexdtricoa m
initial amount: NaN
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: HMDB02288
has only substance units: false
boundary condition: false
name: 4,7,10-hexadecatrienoylcoa
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false

metaM dgtp n
initial concentration: 1.0
is: SBO:0000247
is: HMDB01440
constant: false
initial amount: NaN
type: Species
name: dGTP
is: CHEBI:16497
boundary condition: false
has only substance units: false
is: C00286
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286

metaR FAOXC16180m
modifier: MODEL1310110011#
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110011#
name: Beta oxidation fatty acid
product: MODEL1310110011#
type: Reaction
fast: false
reactant: MODEL1310110011#
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110011#_bcc66ea6_c8f9_4429_b4e6_c7d02c6e89d9
is: Q99808
initial amount: NaN
name: SLC29A1
is encoded by: hsa:2030
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

metaM 4hexdtetcoa m
constant: false
has only substance units: false
is: SBO:0000247
name: 4,7,10,13-hexadecatetraenoylcoa
is: HMDB02288
initial concentration: 1.0
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_39eda9dd_9602_41d1_b0fe_5dd1a970be03
constant: false
has only substance units: false
is encoded by: hsa:27068
name: PPA2
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM HC01407 m
is: SBO:0000247
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:28276
initial amount: NaN
name: (S)-Hydroxyhexanoyl-CoA

metaM nadph x
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: C00005
has only substance units: false
boundary condition: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: HMDB00221
is: CHEBI:57783
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR r2389
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
is: SBO:0000185
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_5aede36b_3f84_478a_88e3_8d2c37e83050
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q13946
initial concentration: NaN
is encoded by: hsa:5150
name: PDE7A
type: Species

metaM 3ddcrn e
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: 3-hydroxydodecanoylcarnitine
boundary condition: false
constant: false
type: Species
is: HMDB00791
notes: FORMULA: C19H37NO5 CHARGE: 0
initial amount: NaN
is: C02838

metaR r0013
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.52 Confidence Level: 0 AUTHORS: PMID:10481922,PMID:2423070,PMID:6219664,PMID:758959 NOTES:
name: beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52
is described by: ECO:0000000
reactant: MODEL1310110011#
product: MODEL1310110011#
reversible: false
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR BPNT
product: MODEL1310110011#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.7
is: SBO:0000176
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
type: Reaction
reversible: false
reactant: MODEL1310110011#
fast: false
name: 3',5'-bisphosphate nucleotidase
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:

metaM hpdca e
is: CHEBI:32366
initial concentration: 1.0
has only substance units: false
name: margarate
type: Species
is: HMDB02259
initial amount: NaN
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
is: SBO:0000247
constant: false
boundary condition: false

metaR r1945
reactant: MODEL1310110011#
product: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110011#
fast: false
is described by: ECO:0000000
reversible: false

metaR FAOXC2051843m
kinetic law: MODEL1310110011#
name: Beta oxidation of fatty acid
is described by: ECO:0000000
reversible: false
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
type: Reaction
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110011#_cea60cbd_081a_4c8a_9630_29ecc06b4733
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
has part: Q9UHI5
constant: false
is encoded by: hsa:23428
initial concentration: NaN
name: SLC7A8:SLC3A2
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110011#_f7cbf4b6_295c_45bd_9323_caef2fa441a5
name: ACOX1
boundary condition: true
is encoded by: hsa:51
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q15067

metaM hxcoa m
constant: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
has only substance units: false
type: Species
is: HMDB06522
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: Hexanoyl-CoA (n-C6:0CoA)

metaM prostge2 e
constant: false
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
type: Species
is: CHEBI:606564
initial amount: NaN
initial concentration: 1.0
is: HMDB01220
is: SBO:0000247
name: prostaglandin E2(1-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_9238dad9_29bb_4889_a52d_ea45fffdd7e6
constant: false
type: Species
has only substance units: false
name: PDE6D
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: O43924
initial concentration: NaN
is encoded by: hsa:5147

metaR THRASNNaEx
fast: false
is: SBO:0000185
name: L-threonine/L-asparagine Na-dependent exchange (Thr-L in)
product: MODEL1310110011#
reversible: false
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_5ee27164_44d5_41b1_81e1_82999921428f
is encoded by: hsa:D29675
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
name: _D29675_1_c
type: Species

metaR EX c8dc
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for suberyl carnitine
type: Reaction

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaM HC02214 e
is: CHEBI:28852
boundary condition: false
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin-f1alpha
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
has only substance units: false

metaR r0579
is version of: http://identifiers.org/ec-code/1.13.11.19
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
product: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_da025200_4bdf_46ef_8897_7fd7b77dc7b6
has only substance units: false
name: ALDH3B2
is encoded by: hsa:222
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: P48448
is: SBO:0000252

metaR HDCAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110011#
name: fatty acid transport via diffusion
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110011#

metaR EX mag hs LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Monoacylglycerol 2 (homo sapiens) exchange
type: Reaction

metaM lnlc c
is: CHEBI:30245
constant: false
boundary condition: false
type: Species
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: linoleate
is: HMDB00673
is: SBO:0000247

metaM g2m8masn r
has only substance units: false
boundary condition: false
initial amount: NaN
is: C05874
constant: false
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C82H137N2O65X CHARGE: 0
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM dcyt e
constant: false
boundary condition: false
is: C00881
is: HMDB00014
is: SBO:0000247
type: Species
name: Deoxycytidine
is: CHEBI:15698
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaM 3mgcoa m
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB01057
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
initial amount: NaN
initial concentration: 1.0
constant: false
name: trans-3-methylglutaconyl-CoA(5-)
is: CHEBI:57346
type: Species

metaR LNELDCCPT1
type: Reaction
modifier: MODEL1310110011#
is described by: ECO:0000269
reactant: MODEL1310110011#
fast: false
reversible: false
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
name: carnitine O-palmitoyltransferase
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110011#_843036ed_477e_46d7_9013_8fa0bf17636d
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:9563
is: O95479
type: Species
name: H6PD

http://identifiers.org/biomodels.db/MODEL1310110011#_41f51744_b7ba_40b0_a9ce_80835605bd99
is: E7EPT3
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
name: ALDH7A1
type: Species
is encoded by: hsa:501

metaR r2511
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
name: Utilized transport
is described by: ECO:0000000
is: SBO:0000185

metaR THYOXt2
reactant: MODEL1310110011#
is described by: ECO:0000269
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000185
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
product: MODEL1310110011#
name: T4 transport via facilitated diffusion

metaR C14OHc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecanoylcarnitine
type: Reaction

metaR UMPK5n
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (dATP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
product: MODEL1310110011#
is: SBO:0000176
modifier: MODEL1310110011#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110011#

metaR LNELDCCPT2
reactant: MODEL1310110011#
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110011#
reversible: false
kinetic law: MODEL1310110011#
name: carnitine transferase
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176

metaM prostge2 c
is: HMDB01220
name: prostaglandin E2(1-)
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
initial amount: NaN
constant: false
is: CHEBI:606564

metaM mercplac c
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
is: HMDB02127
constant: false
initial concentration: 1.0
is: C05823
type: Species
name: 3-Mercaptolactate
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/8118

metaR ARGtm
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110011#
modifier: MODEL1310110011#
name: arginine mitochondrial transport via ornithine carrier
reversible: true
fast: false
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV

metaM HC02214 c
constant: false
is: SBO:0000247
name: prostaglandin-f1alpha
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
boundary condition: false
initial amount: NaN
is: CHEBI:28852

metaM c8dc e
constant: false
is: C02838
boundary condition: false
notes: FORMULA: C15H26NO6 CHARGE: -1
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
name: suberyl carnitine
is: HMDB00791

http://identifiers.org/biomodels.db/MODEL1310110011#_a4a9b133_b4f3_4624_9fe7_6106ddf6faf5
constant: false
name: PDE1A
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q9Y633
is encoded by: hsa:5136
type: Species
has only substance units: false

metaM atp e
initial amount: NaN
is: CHEBI:57299
has only substance units: false
is: HMDB00538
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: C00002
name: ATP(4-)

metaR MG3er
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
fast: false
is: SBO:0000176
product: MODEL1310110011#
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110011#_b66a99b0_a6e7_424e_bf4a_60dac01dc510
initial amount: NaN
boundary condition: true
name: _AI631997_1_m
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI631997
type: Species
constant: false

metaM HC00319 c
name: Malonate
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial concentration: 1.0
is: CHEBI:30794
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_2438bb50_aff9_47c4_8243_ee61f4e41b85
constant: false
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:8639
name: AOC3
initial concentration: NaN
is: SBO:0000252
is: Q16853
initial amount: NaN

metaM nadh c
initial concentration: 1.0
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/3306
is: C00004
name: Nicotinamide adenine dinucleotide - reduced
has only substance units: false
is: CHEBI:57945
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB01487

metaR AMPDA
is version of: http://identifiers.org/ec-code/3.5.4.6
product: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
modifier: MODEL1310110011#
reversible: false
fast: false
name: Adenosine monophosphate deaminase

metaR RE2660N
fast: false
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
modifier: MODEL1310110011#
name: RE2660
is version of: http://identifiers.org/ec-code/4.2.1.96

metaR DITPtn
kinetic law: MODEL1310110011#
fast: false
product: MODEL1310110011#
name: dITP nuclear transport
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000185

metaR SERDGLYexR
is: SBO:0000185
type: Reaction
is described by: ECO:0000304
reversible: true
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
name: D-Serine/Glycine reversible exchange
product: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false

metaR PIACGT
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.4.1.198
is version of: http://identifiers.org/ec-code/2.4.1.83
type: Reaction
reactant: MODEL1310110011#
fast: false
is described by: ECO:0000000
name: phosphatidylinositol N-acetylglucosaminyltransferase
reversible: false
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
is: SBO:0000176
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_1c174e94_3445_488e_bcdd_603064cf87ed
is: SBO:0000252
constant: false
type: Species
is: B3KQH0
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:55343
name: SLC35C1
initial amount: NaN

metaR CHOLD2m
name: choline dehydrogenase (FAD acceptor), mitochondrial
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110011#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (55349.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.99.1 Confidence Level: 4 AUTHORS: PMID:15321791 NOTES:
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.99.1
product: MODEL1310110011#
is: SBO:0000176
kinetic law: MODEL1310110011#

metaM 13dampp c
boundary condition: false
has only substance units: false
is: CHEBI:57484
name: trimethylenediaminium
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
is: HMDB00002
initial concentration: 1.0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_e59b30ef_f731_4289_9e19_5019427ffdc6
has only substance units: false
initial amount: NaN
type: Species
name: ST3GAL3
is encoded by: hsa:6487
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_8f6ec37a_e150_4bf5_a998_29b6da4c3ccf
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:AI694761
name: _AI694761_1_c
initial amount: NaN

metaM atp c
is: C00002
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: ATP(4-)
initial concentration: 1.0
is: CHEBI:30616
is: HMDB00538

metaR r2514
is: SBO:0000185
name: Utilized transport
is described by: ECO:0000000
type: Reaction
product: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
kinetic law: MODEL1310110011#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_caafa838_6d3e_46de_8ed5_258a28bf18c6
name: ST3GAL3
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6487
boundary condition: true
initial concentration: NaN
type: Species
constant: false
initial amount: NaN

metaM c8dc c
has only substance units: false
is: HMDB00791
boundary condition: false
constant: false
notes: FORMULA: C15H26NO6 CHARGE: -1
is: C02838
initial concentration: 1.0
name: suberyl carnitine
type: Species
is: SBO:0000247
initial amount: NaN

metaM datp c
name: dATP
is: C00131
has only substance units: false
constant: false
type: Species
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: HMDB01532
initial concentration: 1.0
boundary condition: false
is: CHEBI:61404
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_1aa4e3a5_4dbe_44b5_b985_1264820a4731
has only substance units: false
type: Species
is encoded by: hsa:2645
constant: false
is: SBO:0000252
boundary condition: true
name: GCK
is: P35557
initial amount: NaN
initial concentration: NaN

metaM 2obut m
is: CHEBI:16763
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00005
initial amount: NaN
name: 2-oxobutanoate

metaM ttetddcoa m
has only substance units: false
type: Species
boundary condition: false
is: HMDB02288
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
name: trans5,8tetradecadienoylcoa
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_45806448_70d1_4575_8778_178057c2be7d
has only substance units: false
name: ATP2B4
is: P23634
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:493

http://identifiers.org/biomodels.db/MODEL1310110011#_815c6904_61bc_480a_9c1c_c6799944a54c
is: Q9NRZ7
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: AGPAT3
is encoded by: hsa:56894
has only substance units: false

metaR EX gsn LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Guanosine
type: Reaction

metaR RE1342C
name: RE1342
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
type: Reaction
product: MODEL1310110011#
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_1c653f26_8cbd_4432_9c86_016c715c0af2
initial concentration: NaN
is: D6RDW3
name: GUCY1A3
type: Species
boundary condition: true
is encoded by: hsa:2982
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM lald D c
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:17167
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB06458
name: (R)-lactaldehyde
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_11f9834b_4742_4e9b_a10f_e970d0aa224f
type: Species
is encoded by: hsa:8836
constant: false
is: Q92820
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: GGH
has only substance units: false

metaR CYTK12
fast: false
reactant: MODEL1310110011#
is: SBO:0000176
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
name: cytidylate kinase (dCMP,dCTP)
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR SCP2x
is described by: ECO:0000269
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.176
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways version 2 analog added as per KEGG NJ
product: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
reversible: false
reactant: MODEL1310110011#
name: peroxisomal thiolase 2

metaR r2094
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110011#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110011#
reversible: true
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaR SCP21cx
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of phytanoylcoa from cytosol to peroxisomes.
type: Reaction

metaM tetdec2coa c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
boundary condition: false
constant: false
name: tetradecadienoylcoa
is: HMDB02014
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_de8b5310_c712_4207_9a5a_d6ea65922522
initial concentration: NaN
type: Species
name: _AI926493_1_c
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:AI926493
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_74a1fae2_758d_43bb_8fb2_cf0f9fa26619
is: O75414
is encoded by: hsa:10201
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
type: Species
name: NME6
has only substance units: false

metaR ITPtn
product: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110011#
name: ITP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110011#

metaM nadph r
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: SBO:0000247
is: C00005
constant: false
is: HMDB00221
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: CHEBI:57783
type: Species

metaR C204CPT1
reactant: MODEL1310110011#
modifier: MODEL1310110011#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (1374.1) or (1375.4) or (1375.1) or (1375.3) or (1375.2) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
fast: false
is described by: ECO:0000000
name: carnitine C20:4 transferase
reversible: false
kinetic law: MODEL1310110011#

metaR GLYOp
fast: false
product: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9038835 NOTES:
kinetic law: MODEL1310110011#
type: Reaction
name: glycine oxidase, perixosomal
is: SBO:0000176
reactant: MODEL1310110011#
reversible: false

metaR FAOXC7C5m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C7-->C5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_83783678_d2a7_4883_9844_d422c843fed1
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:55825
name: PECR
is: SBO:0000252
is: Q9BY49
initial concentration: NaN
constant: false

metaM prgstrn e
is: HMDB01830
initial concentration: 1.0
constant: false
name: progesterone
type: Species
is: CHEBI:17026
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410

metaR CYTK11
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110011#
name: cytidylate kinase (dCMP,dGTP)
is: SBO:0000176
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
fast: false
reactant: MODEL1310110011#
is described by: ECO:0000269
type: Reaction

metaR r2095
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110011#
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
modifier: MODEL1310110011#

metaR 4HBZCOAFm
fast: false
is: SBO:0000176
name: 4-hydroxybenzoyl-CoA formation
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
product: MODEL1310110011#
type: Reaction
reversible: false
reactant: MODEL1310110011#
is described by: ECO:0000000

metaR EX 4nph LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenol exchange
type: Reaction

metaM m5mpdol L r
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C1600H2628N20O470P20 CHARGE: -20
type: Species
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false
has only substance units: false
is: CHEBI:37634
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_d66e5968_85f5_4c7f_9e52_576989406c8b
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
name: _728226_1_e
boundary condition: true
is encoded by: hsa:728226

http://identifiers.org/biomodels.db/MODEL1310110011#_0f4959bb_84ef_4d81_aa5f_284d3597e23b
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q9NP59
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: SLC40A1
is encoded by: hsa:30061

metaR CYTK10
kinetic law: MODEL1310110011#
reversible: true
type: Reaction
name: cytidylate kinase (CMP,dGTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110011#
is: SBO:0000176
fast: false
modifier: MODEL1310110011#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110011#

metaR r2096
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110011#_7a5b61f9_eafa_4571_8ad6_5c8120eb5ce3
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:204
has only substance units: false
initial amount: NaN
name: AK2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_850499f4_503d_4c9b_92f7_ca6b9df599d6
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q96G03
type: Species
initial concentration: NaN
constant: false
name: PGM2
is: SBO:0000252
is encoded by: hsa:55276

metaR FAOXC260240x
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: false
is described by: ECO:0000000
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c26:0 -> c24:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 -> into pmtcoa NJ
fast: false
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_bacc9b0f_6a26_4252_b4dc_e05079c81128
has only substance units: false
boundary condition: true
is: O43252
is encoded by: hsa:9061
initial amount: NaN
constant: false
is: SBO:0000252
name: PAPSS1
type: Species
initial concentration: NaN

metaR r0426
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.34
reactant: MODEL1310110011#
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#

metaM prgstrn c
initial amount: NaN
name: progesterone
is: HMDB01830
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
is: CHEBI:17026
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_88bf1410_faea_4f61_93a8_6f0a065ac387
boundary condition: true
initial amount: NaN
name: PLCG1
is: Q9UFY1
type: Species
initial concentration: NaN
is encoded by: hsa:5335
constant: false
has only substance units: false
is: SBO:0000252

metaR FAOXC2252053m
kinetic law: MODEL1310110011#
reversible: false
reactant: MODEL1310110011#
is described by: ECO:0000000
name: Beta oxidation of long chain fatty acid
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176

metaR FAOXC241181x
product: MODEL1310110011#
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:1 -> c18:1 - 3 rounds beta-ox 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000269
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110011#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: false

metaR AMPtp
product: MODEL1310110011#
is: SBO:0000185
name: AMP transporter, peroxisome
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
is described by: ECO:0000000

metaR MELATNOX
reversible: false
notes: GENE_ASSOCIATION: (1557.1) or (1543.1) or (1545.1) or (1544.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15616152 NOTES:SAB made up name
product: MODEL1310110011#
fast: false
is: SBO:0000176
modifier: MODEL1310110011#
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.48
reactant: MODEL1310110011#
name: Melatonin:NADP oxidoreductase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.14.1
kinetic law: MODEL1310110011#

metaM thcholstoic c
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB03873
has only substance units: false
is: CHEBI:18402
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
type: Species

metaR r2097
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110011#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
reversible: true
type: Reaction

metaR FAOXC142C142OHm
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C14:2OH)m
type: Reaction

metaM sphmyln hs c
initial concentration: 1.0
is: CHEBI:58216
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
name: sphingomyelin betaine
initial amount: NaN
is: SBO:0000247
constant: false

metaR MI134P4P
kinetic law: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
name: inositol-1,3,4-trisphosphate 4-phosphatase
fast: false
reactant: MODEL1310110011#
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

metaR G14T7g
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110011#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reactant: MODEL1310110011#
is described by: ECO:0000000
modifier: MODEL1310110011#
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_3a16fa59_8162_490e_8bc3_457664ac0348
initial amount: NaN
is: Q15102
name: PAFAH1B3
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5050
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_5ba05bb9_c6cb_43cb_acb0_760eb5b070de
name: AK4
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P27144
type: Species
has only substance units: false
is encoded by: hsa:205
initial amount: NaN

metaR ORNt4m
kinetic law: MODEL1310110011#
is: SBO:0000185
type: Reaction
product: MODEL1310110011#
name: ornithine mitochondrial transport exchange with citruline
fast: false
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
reactant: MODEL1310110011#
modifier: MODEL1310110011#

metaR r2098
reversible: true
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110011#
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r0160
type: Reaction
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.1.3.2
product: MODEL1310110011#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110011#
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
reversible: false
reactant: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:

metaM ala L m
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00161
initial concentration: 1.0
name: L-alanine
has only substance units: false
is: CHEBI:16977
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
constant: false

metaR C10DCe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of sebacoyl carnitine into extra cellular space
type: Reaction

metaM eicostetcrn c
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01356
is: SBO:0000247
name: Eicosatetranoyl carnitine
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
type: Species
has only substance units: false
is: CHEBI:57312

metaR COUCOAFm
kinetic law: MODEL1310110011#
type: Reaction
fast: false
name: p-coumaroyl-CoA formation
reversible: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: 6.2.1.12 Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine. (EC 6.2.1.12) .
product: MODEL1310110011#

metaR PECDCHe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of pectins with deoxycholic acid in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaM 2obut c
is: HMDB00005
initial amount: NaN
is: C00109
name: 2-Oxobutanoate
is: SBO:0000247
is: CHEBI:16763
has only substance units: false
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
boundary condition: false
constant: false
initial concentration: 1.0

metaM k e
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: HMDB00586
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
is: C00238
name: potassium
initial amount: NaN
is: CHEBI:29103

metaR r0424
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000176
reactant: MODEL1310110011#
reversible: true
is described by: ECO:0000000
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is version of: http://identifiers.org/ec-code/1.17.1.4
fast: false
type: Reaction
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_f22aa608_8a09_407c_96d0_2dd7f0a99dc0
name: PDE4A
is: SBO:0000252
is: P27815
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5141
initial amount: NaN
boundary condition: true

metaM lnlc e
initial amount: NaN
is: CHEBI:30245
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
boundary condition: false
is: HMDB00673
constant: false
is: SBO:0000247
type: Species
name: linoleate
has only substance units: false
initial concentration: 1.0

metaR AG13T6g
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110011#
type: Reaction
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110011#
reversible: false

metaR CYOOm3
product: MODEL1310110011#
is described by: ECO:0000134
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.9.3.1
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
kinetic law: MODEL1310110011#
is: SBO:0000185
name: cytochrome c oxidase, mitochondrial Complex IV
fast: false
type: Reaction
reversible: false
modifier: MODEL1310110011#

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaR r2099
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110011#
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: true
reactant: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM atp n
initial concentration: 1.0
type: Species
is: HMDB00538
is: CHEBI:57299
initial amount: NaN
name: ATP(3-)
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002

metaR MALTSULtm
type: Reaction
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false
modifier: MODEL1310110011#
name: Malate:thiosulfate antiport, mitochondrial
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185

metaM m7mpdol L r
type: Species
is: CHEBI:37636
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C1720H2828N20O570P20 CHARGE: -20
initial concentration: 1.0
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false

metaR r0423
fast: false
modifier: MODEL1310110011#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is: SBO:0000176
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
type: Reaction

metaM dopa e
initial concentration: 1.0
is: CHEBI:59905
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
constant: false
is: SBO:0000247
name: dopaminium(1+)
is: HMDB00073

http://identifiers.org/biomodels.db/MODEL1310110011#_f4e7cb28_ed03_41e6_a46f_bd537b58d47c
initial amount: NaN
is: Q8N5Z0
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
name: AADAT
is encoded by: hsa:51166
constant: false
has only substance units: false

metaR C204CPT2
type: Reaction
is: SBO:0000176
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
fast: false
name: arachidonic acid transport into the mitochondria
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
modifier: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_2c0d76b6_7c10_4632_8175_a1c386ff3e93
initial amount: NaN
constant: false
is encoded by: hsa:8875
is encoded by: hsa:55350
boundary condition: true
has part: O95498
is: SBO:0000297
has only substance units: false
name: VNN3:VNN2:VNN1
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_286a7ee0_5d4d_4441_ba89_186bb1c5e06b
is: Q01433
type: Species
name: AMPD2
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:271
is: SBO:0000252

metaM 56dura c
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00076
is: CHEBI:15901
is: SBO:0000247
name: 5,6-dihydrouracil
type: Species
constant: false

metaM dcamp c
is: C03794
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
initial concentration: 1.0
has only substance units: false
name: N6-(1,2-Dicarboxyethyl)-AMP
constant: false
is: CHEBI:57567
type: Species
is: SBO:0000247
is: HMDB00536
boundary condition: false
initial amount: NaN

metaM atp m
boundary condition: false
is: HMDB00538
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: C00002
is: CHEBI:57299
name: ATP(4-)
constant: false
type: Species

metaM ach c
is: CHEBI:15355
is: SBO:0000247
boundary condition: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial amount: NaN
name: acetylcholine
type: Species
is: HMDB00895
has only substance units: false
constant: false
initial concentration: 1.0

metaM gluala e
type: Species
initial concentration: 1.0
has only substance units: false
name: 5-L-Glutamyl-L-alanine
is: http://identifiers.org/pubchem.compound/6503
boundary condition: false
initial amount: NaN
is: C03740
is: HMDB06248
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_14982d98_b41e_49d6_8fe0_656d6539c1cc
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110011#_2620fed0_92cd_4ff7_8acb_2f29bacd5a0b
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaM k c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00586
constant: false
boundary condition: false
is: SBO:0000247
name: potassium
type: Species
is: C00238
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: CHEBI:29103

metaM dcyt n
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: CHEBI:15698
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: 2'-deoxycytidine
constant: false
boundary condition: false
type: Species
is: HMDB00014
initial concentration: 1.0

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_88268630_0c58_41ef_9c3c_82797a646c26
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:112
has only substance units: false
name: ADCY6

metaM 5adtststerones c
is: HMDB06278
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: 5alpha-Dihydrotestosterone sulfate
constant: false
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
initial concentration: 1.0
has only substance units: false

metaR SUCCTD
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaM HC00319 m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
boundary condition: false
is: CHEBI:30794
name: Malonate
type: Species
initial amount: NaN

metaM gly m
initial concentration: 1.0
has only substance units: false
is: CHEBI:15428
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: SBO:0000247
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: C00037
name: Glycine
is: HMDB00123

metaM acrn c
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
has only substance units: false
name: O-acetylcarnitine
is: CHEBI:57589
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB00201

metaR GLYBt4 2 r
product: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000185
modifier: MODEL1310110011#
is described by: ECO:0000269
name: Betaine transport (sodium symport) (2:1)
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6539.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

metaM betald c
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB01252
initial amount: NaN
type: Species
is: CHEBI:15710
boundary condition: false
has only substance units: false
name: betaine aldehyde

http://identifiers.org/biomodels.db/MODEL1310110011#_16ba387f_3a4b_4ce2_98a4_01277b53f526
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:100128062
is: SBO:0000252
constant: false
type: Species
name: _100128062_1_m

metaM nadh x
name: Nicotinamide adenine dinucleotide - reduced
is: CHEBI:57945
type: Species
initial amount: NaN
is: C00004
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB01487
is: http://identifiers.org/pubchem.compound/3306
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_dc95b151_30d8_4d35_83fa_1f10705f6fd9
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:125
constant: false
is: P00325
boundary condition: true
name: ADH1B

metaR MEVK1x
reactant: MODEL1310110011#
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.1.36
kinetic law: MODEL1310110011#
is described by: ECO:0000134
product: MODEL1310110011#
fast: false
name: mevalonate kinase (atp)
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.1.36 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version NJ

http://identifiers.org/biomodels.db/MODEL1310110011#_74041997_fe8c_49fe_bb70_363accc37dff
boundary condition: true
initial amount: NaN
name: SGPP1
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q9BX95
has only substance units: false
constant: false
is encoded by: hsa:81537

http://identifiers.org/biomodels.db/MODEL1310110011#_36c7d438_8a5a_44c2_ad6b_575a3367910a
is encoded by: hsa:8875
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: A8K7W0
name: VNN2
boundary condition: true
constant: false
type: Species
is: SBO:0000252

metaM ps hs m
type: Species
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
constant: false
is: SBO:0000247
name: ps_hs[m]
initial amount: NaN
is: CHEBI:18303
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM 3mop e
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
has only substance units: false
boundary condition: false
name: 3-methyl-2-oxopentanoate
is: SBO:0000247
is: CHEBI:28654
is: HMDB00491
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN

metaM atp r
boundary condition: false
initial concentration: 1.0
is: C00002
is: SBO:0000247
initial amount: NaN
is: CHEBI:57299
constant: false
name: ATP(4-)
type: Species
has only substance units: false
is: HMDB00538

http://identifiers.org/biomodels.db/MODEL1310110011#_ed30ee1f_911b_466e_a15f_8574fe0e3abd
type: Species
is encoded by: hsa:7296
initial amount: NaN
constant: false
has only substance units: false
name: TXNRD1
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR C6DCe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of adipoyl carnitine into the extra cellular fluid
type: Reaction

metaM pydx5p e
is: SBO:0000247
is: HMDB01491
has only substance units: false
constant: false
type: Species
notes: FORMULA: C8H8NO6P CHARGE: -2 INCHI: InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)/p-2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
boundary condition: false
is: CHEBI:597326
name: pyridoxal 5'-phosphate(2-)
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_53d99c56_2bed_4961_a4d5_f796d76926f0
name: MBOAT7
boundary condition: true
type: Species
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q96N66
is encoded by: hsa:79143
is: SBO:0000252

metaM C05280 m
initial amount: NaN
is: CHEBI:28002
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
initial concentration: 1.0
name: cis,cis-3,6-Dodecadienoyl-CoA
has only substance units: false
constant: false
type: Species
is: HMDB03952
is: SBO:0000247
boundary condition: false

metaR ORNDC
notes: GENE_ASSOCIATION: (4953.1) SUBSYSTEM: Urea cycle EC Number: 4.1.1.17 Confidence Level: 4 AUTHORS: PMID:2317811 NOTES:JLR- added proton to balance
type: Reaction
reversible: false
reactant: MODEL1310110011#
name: Ornithine Decarboxylase
kinetic law: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.17
modifier: MODEL1310110011#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110011#

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_246ba881_27a8_4b10_a355_670b1564c953
type: Species
is: SBO:0000252
name: PCBD1
constant: false
initial concentration: NaN
is: P61457
is encoded by: hsa:5092
initial amount: NaN
boundary condition: true
has only substance units: false

metaR INSTt4 2
fast: false
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
product: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
modifier: MODEL1310110011#
reversible: true
name: inositol transport via sodium symport
is described by: ECO:0000006
is: SBO:0000185
kinetic law: MODEL1310110011#

metaM ach e
name: acetylcholine
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
type: Species
initial amount: NaN
is: HMDB00895
is: CHEBI:15355
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_f5dee7f8_97e6_4937_a277_ee01cddda024
name: _NOS2A_1_c
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:NOS2A
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR HYXNt
kinetic law: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
is: SBO:0000185
is described by: ECO:0000269
reversible: true
product: MODEL1310110011#
modifier: MODEL1310110011#
name: Hypoxanthine transport

http://identifiers.org/biomodels.db/MODEL1310110011#_b585871d_83b3_4427_9d6a_5852ef960226
constant: false
boundary condition: true
type: Species
is: SBO:0000252
name: _H17063_1_c
has only substance units: false
initial amount: NaN
is encoded by: hsa:H17063
initial concentration: NaN

metaR r0726
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
kinetic law: MODEL1310110011#
is: SBO:0000176
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
product: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.33

metaR ADPtx
type: Reaction
name: ADP transporter, peroxisomal
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
fast: false
is: SBO:0000185

metaR RIBt
is described by: ECO:0000000
product: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110011#
type: Reaction
is: SBO:0000185
name: ribose transport via diffusion

metaR GLYCTDle
product: MODEL1310110011#
is described by: ECO:0000134
kinetic law: MODEL1310110011#
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: difussion of glycerol accross the brush border membrane

http://identifiers.org/biomodels.db/MODEL1310110011#_bd400556_0e36_4785_932e_079b010a140d
boundary condition: true
constant: false
is encoded by: hsa:80704
is: Q9BZV2
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
name: SLC19A3
initial concentration: NaN

metaR LGNCCOAtx
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
fast: false
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110011#
is described by: ECO:0000000

metaM itacon m
initial amount: NaN
is: HMDB02092
has only substance units: false
constant: false
is: CHEBI:17240
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
is: SBO:0000247
boundary condition: false
type: Species
name: itaconate(2-)
initial concentration: 1.0

metaM so4 c
name: sulfate
has only substance units: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
is: HMDB01448
initial amount: NaN
is: CHEBI:16189
boundary condition: false

metaM dutp c
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB01191
name: dUTP
is: C00460
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: CHEBI:17625

http://identifiers.org/biomodels.db/MODEL1310110011#_678b75c1_fdc6_4fd6_b2f4_1ab04efd346a
constant: false
initial concentration: NaN
is encoded by: hsa:4720
has only substance units: false
is: B7Z792
is: SBO:0000252
type: Species
name: NDUFS2
initial amount: NaN
boundary condition: true

metaR C6DCc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoylcarnitine
type: Reaction

metaM 2dp6mobq m
type: Species
name: 2-decaprenyl-6-methoxy-1,4-benzoquinone
is: CHEBI:50773
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C57H86O3 CHARGE: 0 INCHI: InChI=1S/C57H86O3/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58)43-56(60-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
initial concentration: 1.0
has only substance units: false

metaM strdnccoa m
has only substance units: false
is: SBO:0000247
is: C16163
name: stearidonyl coenzyme A
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: HMDB06519
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205473
initial amount: NaN
initial concentration: 1.0

metaM 3mop c
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
is: SBO:0000247
initial amount: NaN
is: CHEBI:28654
constant: false
type: Species
has only substance units: false
name: 3-methyl-2-oxopentanoate
boundary condition: false
is: HMDB00491
initial concentration: 1.0

metaR r0165
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110011#
name: UTP:pyruvate O2-phosphotransferase EC:2.7.1.40
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110011#
reactant: MODEL1310110011#
product: MODEL1310110011#

metaR THD1m
product: MODEL1310110011#
name: NAD(P) transhydrogenase
is: SBO:0000185
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES:TDV (2-6-2003)
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110011#
type: Reaction
is version of: http://identifiers.org/ec-code/1.6.1.2
fast: false
modifier: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_52ac929b_2f40_4b07_ad97_b8b340d811d7
name: PIGH
is encoded by: hsa:5283
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: Q14442
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_07f024ad_99fa_4c02_b6f4_dc66951181a2
has only substance units: false
is: P48067
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:6536
name: SLC6A9
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM HC02203 c
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: CHEBI:27820
has only substance units: false
name: prostaglandin-a2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
is: SBO:0000247

metaR MTHFDm
type: Reaction
is: SBO:0000176
reactant: MODEL1310110011#
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
product: MODEL1310110011#
fast: false
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.5.4.9
is version of: http://identifiers.org/ec-code/6.3.4.3
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial

metaM m8masn r
type: Species
initial amount: NaN
notes: FORMULA: C70H117N2O55X CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
is: C05876
boundary condition: false
constant: false
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false

metaR EX 3ddcrn
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

metaM 34dhoxmand m
initial concentration: 1.0
type: Species
name: 3,4-Dihydroxymandelate
is: CHEBI:27637
is: SBO:0000247
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
initial amount: NaN
has only substance units: false
is: HMDB01866
boundary condition: false
constant: false

metaM lnlc r
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00673
boundary condition: false
is: SBO:0000247
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
initial amount: NaN
name: linoleate
is: CHEBI:30245
constant: false

metaM lys L m
initial concentration: 1.0
name: L-lysinium(1+)
is: HMDB00182
has only substance units: false
constant: false
is: CHEBI:32551
type: Species
is: SBO:0000247
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
boundary condition: false
initial amount: NaN

metaR FUMtm
name: fumarate transport, mitochondrial
kinetic law: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
is: SBO:0000185
fast: false
is described by: ECO:0000269
product: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
reactant: MODEL1310110011#

metaR C10DCc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoylcarnitine
type: Reaction

metaR r0166
kinetic law: MODEL1310110011#
is: SBO:0000176
is described by: ECO:0000000
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
reactant: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110011#
type: Reaction
reversible: false

metaR DURIt
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
name: deoxyuridine transport via diffusion

metaR ARACHDt2
fast: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
reactant: MODEL1310110011#
type: Reaction
name: fatty acid transport via diffusion
reversible: true
is described by: ECO:0000000

metaM galside hs e
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
name: D-galactosyl-N-acylsphingosine
is: CHEBI:12947
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_d529c2e4_2217_40c6_9dbc_3f7e3d27f752
is encoded by: hsa:8034
name: SLC25A16
is: SBO:0000252
is: P16260
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
constant: false

metaR HIVCACBP
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyisovalerylcoa from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_7f165ceb_7da0_435b_8f4a_e4445c2d7f6a
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: E9KL44
name: HADHA
constant: false
is encoded by: hsa:3030

metaR r0728
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110011#
type: Reaction
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reversible: true
is described by: ECO:0000000

metaR PCRNtm
fast: false
product: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
kinetic law: MODEL1310110011#
is: SBO:0000185
name: transport into the mitochondria from cytosol (carnitine)
reactant: MODEL1310110011#

metaR SCP21x
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.176
modifier: MODEL1310110011#
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
name: Sterol carrier protein 2
is: SBO:0000185
fast: false
product: MODEL1310110011#
is described by: ECO:0000269

metaR r2380
reversible: true
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110011#
type: Reaction
fast: false
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_0205e47b_b3b1_4c40_8d8a_13a1f215bc7d
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:6582
type: Species
is: O15244
is: SBO:0000252
boundary condition: true
name: SLC22A2

metaR PMANM
modifier: MODEL1310110011#
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/5.4.2.8
kinetic law: MODEL1310110011#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110011#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/5.4.2.2
name: phosphomannomutase
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:

metaM m6masnC g
is: CHEBI:30825
type: Species
initial amount: NaN
is: HMDB00573
notes: FORMULA: C58H97N2O45X CHARGE: 0
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

metaR PPCOAOm
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110011#
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
product: MODEL1310110011#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110011#
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial

metaM HC02203 e
has only substance units: false
type: Species
initial concentration: 1.0
name: prostaglandin-a2
is: SBO:0000247
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
is: CHEBI:27820
boundary condition: false
initial amount: NaN

metaR HGNTOR
modifier: MODEL1310110011#
reversible: false
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.13.11.5
product: MODEL1310110011#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_da761b95_130d_4998_85e6_8615fac3c239
name: SLC4A5
is: Q9BY07
constant: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:57835
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_f7cc3bdd_75de_448c_af7d_f41f0aeca3f5
type: Species
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q9H008
is encoded by: hsa:64077
name: LHPP

http://identifiers.org/biomodels.db/MODEL1310110011#_e9ec09b4_041f_492e_9413_34204df49cba
has part: Q15102
is encoded by: hsa:5049
initial concentration: NaN
type: Species
is encoded by: hsa:5050
boundary condition: true
initial amount: NaN
is: SBO:0000297
has part: A8DPS7
constant: false
name: PAFAH1B2:PAFAH1B3
has only substance units: false

metaR GLNTHRNaEx
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
product: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-threonine/L-glutamine Na-dependent exchange (Gln-L in)
kinetic law: MODEL1310110011#
reversible: false

metaM 4fumacac c
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
initial concentration: 1.0
type: Species
name: 4-fumarylacetoacetate(2-)
is: CHEBI:18034
has only substance units: false
constant: false
is: HMDB01268
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR URIt
product: MODEL1310110011#
is: SBO:0000185
modifier: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
reversible: true
is described by: ECO:0000269
name: uridine facilated transport in cytosol

metaR r0722
product: MODEL1310110011#
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.3.12
fast: false
modifier: MODEL1310110011#
reversible: true
is described by: ECO:0000000

metaM crvnc e
initial concentration: 1.0
is: HMDB02183
is: SBO:0000247
type: Species
has only substance units: false
constant: false
notes: FORMULA: C22H31O2 CHARGE: -1
boundary condition: false
initial amount: NaN
is: CHEBI:36005
name: cervonic acid, C22:6 n-3

metaM lnlc l
initial amount: NaN
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
boundary condition: false
is: CHEBI:30245
initial concentration: 1.0
name: linoleate
type: Species
is: HMDB00673
constant: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_d6316fa3_78ed_4813_9bba_d14c52fef37d
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
name: _NM_013421_1_m
initial amount: NaN
boundary condition: true
is encoded by: hsa:NM 013421

metaM pydx5p c
name: Pyridoxal 5'-phosphate
has only substance units: false
boundary condition: false
is: HMDB01491
is: C00018
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C8H8NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
is: CHEBI:597326
initial amount: NaN
is: SBO:0000247

metaM chol n
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:15354
name: choline
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
has only substance units: false
is: SBO:0000247
is: HMDB00097
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_29c60e51_141a_45a8_8646_40a237f66cf4
is: SBO:0000252
is encoded by: hsa:57665
constant: false
type: Species
boundary condition: true
initial concentration: NaN
name: RDH14
has only substance units: false
initial amount: NaN
is: Q9HBH5

metaM nadh r
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01487
is: CHEBI:57945
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
type: Species
name: NADH(2-)
constant: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_1750fbf1_e2ac_401a_aef7_c383a5b709de
is: Q92903
initial amount: NaN
initial concentration: NaN
name: CDS1
type: Species
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1040

metaR LTC4CP
is described by: ECO:0000000
product: MODEL1310110011#
is: SBO:0000176
name: Leukotriene C4 carboxypeptidase
fast: false
type: Reaction
kinetic law: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
reactant: MODEL1310110011#

metaR AMETr
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
fast: false
type: Reaction
reactant: MODEL1310110011#
reversible: true
kinetic law: MODEL1310110011#
name: S-Adenosyl-L-methionine intracellular diffusion
product: MODEL1310110011#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_5b61ac79_ae60_424a_bd48_17935d760f9c
has only substance units: false
name: AFMID
is: Q63HM1
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:125061
initial amount: NaN
constant: false
type: Species

metaM mi13p c
is: CHEBI:18225
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: HMDB06234
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
name: 1D-myo-Inositol 1,3-bisphosphate
has only substance units: false
is: SBO:0000247

metaR CYTK13
product: MODEL1310110011#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110011#
name: cytidylate kinase (dCMP,dATP)
reactant: MODEL1310110011#
is: SBO:0000176
modifier: MODEL1310110011#
reversible: true
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM CE5236 c
boundary condition: false
type: Species
is: HMDB03952
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
name: O2'-4a-cyclic-tetrahydrobiopterin
initial concentration: 1.0
is: CHEBI:28002

metaR Htr
product: MODEL1310110011#
reactant: MODEL1310110011#
reversible: true
kinetic law: MODEL1310110011#
name: H transporter, endoplasmic reticulum
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
is described by: ECO:0000000
type: Reaction

metaR NICRNTtn
is: SBO:0000185
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
name: NICRNT transport, nuclear trhough pore
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110011#
fast: false
type: Reaction
kinetic law: MODEL1310110011#

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaM chol m
is: CHEBI:15354
has only substance units: false
is: SBO:0000247
is: HMDB00097
name: choline
initial amount: NaN
type: Species
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
boundary condition: false
initial concentration: 1.0

metaR EX dgsn LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyguanosine
type: Reaction

metaR r0580
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
product: MODEL1310110011#
reversible: true
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
type: Reaction
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.99.7

http://identifiers.org/biomodels.db/MODEL1310110011#_55ffa6a2_eb3b_417e_97cc_1a9744b725d9
initial concentration: NaN
is encoded by: hsa:7296
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
name: TXNRD1
is: SBO:0000252
is: Q16881
type: Species

metaR r0724
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reactant: MODEL1310110011#
is: SBO:0000176
product: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.33
kinetic law: MODEL1310110011#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110011#
reversible: true

metaR RE3347C
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
reversible: true
name: RE3347
reactant: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110011#
fast: false

metaR CYTK14
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110011#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
reversible: true
name: cytidylate kinase (dCMP,UTP)
reactant: MODEL1310110011#
type: Reaction

metaM crvnc c
notes: FORMULA: C22H31O2 CHARGE: -1
is: HMDB02183
name: cervonic acid, C22:6 n-3
has only substance units: false
initial amount: NaN
is: CHEBI:36005
boundary condition: false
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0

metaR FAOXC122m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaR HISTAtu
type: Reaction
fast: false
name: Histamine uniport
reactant: MODEL1310110011#
product: MODEL1310110011#
reversible: true
modifier: MODEL1310110011#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

metaM gly x
name: glycine
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00123
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: CHEBI:15428
type: Species
initial amount: NaN

metaM m7masnC g
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform C (protein)
is: CHEBI:58282
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C64H107N2O50X CHARGE: 0
is: HMDB00968

metaM dutp n
type: Species
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: CHEBI:17625
is: SBO:0000247
is: HMDB01191
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
name: dUTP

metaM 3mop m
constant: false
boundary condition: false
name: 3-methyl-2-oxopentanoate
type: Species
is: SBO:0000247
is: CHEBI:28654
is: HMDB00491
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
initial amount: NaN

metaR r2384
product: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110011#
fast: false
is: SBO:0000185
reactant: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR MM5ag
is version of: http://identifiers.org/ec-code/3.2.1.113
reactant: MODEL1310110011#
is: SBO:0000176
product: MODEL1310110011#
fast: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD

metaR CITL
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
kinetic law: MODEL1310110011#
name: Citrate lyase
is: SBO:0000176
product: MODEL1310110011#
modifier: MODEL1310110011#

metaR LYStip
fast: false
kinetic law: MODEL1310110011#
is: SBO:0000185
reversible: false
product: MODEL1310110011#
is described by: ECO:0000000
name: L-lysine transport, peroxisomal (irreversible)
reactant: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110011#_27eea4c4_da5c_421a_8716_11906bac6ed0
is: SBO:0000252
initial concentration: NaN
name: PDE9A
has only substance units: false
boundary condition: true
is encoded by: hsa:5152
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_831c6348_add7_44d6_b90e_e145fe14b086
name: ALG3
type: Species
initial concentration: NaN
is encoded by: hsa:10195
has only substance units: false
boundary condition: true
constant: false
is: Q92685
is: SBO:0000252
initial amount: NaN

metaM ps hs e
is: SBO:0000247
name: phosphatidylserine
type: Species
constant: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
boundary condition: false
initial amount: NaN
is: CHEBI:18303
has only substance units: false
initial concentration: 1.0

metaR H6ET3er
type: Reaction
reversible: false
product: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.8.1
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
is described by: ECO:0000000
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
kinetic law: MODEL1310110011#

metaM srtn e
has only substance units: false
is: HMDB00259
boundary condition: false
initial concentration: 1.0
is: CHEBI:350546
constant: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
initial amount: NaN
type: Species
name: serotonin(1+)
is: SBO:0000247

metaM dutp m
name: dUTP
is: CHEBI:17625
constant: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
boundary condition: false
is: HMDB01191
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_c9c89393_15b5_4f51_b906_962699724472
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:AI915649
name: _AI915649_1_c
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_901d2fa1_364f_4780_b311_e0911aa20efe
is encoded by: hsa:10797
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: P13995
name: MTHFD2
type: Species
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_b895e5e3_4095_450e_bd72_fca772dc4a3a
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is: Q709F0
name: ACAD11
boundary condition: true
is encoded by: hsa:84129
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_f037694d_1384_4c2c_9061_f5b087df5486
is encoded by: hsa:2678
boundary condition: true
initial amount: NaN
name: GGT1
is: P19440
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252

metaM dgdp c
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: CHEBI:58595
constant: false
has only substance units: false
name: dGDP
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: C00361
is: HMDB00960
type: Species

metaR RE3326M
modifier: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
product: MODEL1310110011#
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
name: RE3326
is version of: http://identifiers.org/ec-code/1.2.4.4

metaM 6thf e
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
has only substance units: false
is: http://identifiers.org/pubchem.compound/169691
type: Species
initial amount: NaN
name: hexaglutamyl folate (THF)
constant: false

metaR ALR3
fast: false
is: SBO:0000176
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110011#
reversible: false
modifier: MODEL1310110011#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.21
name: aldose reductase (acetol)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
kinetic law: MODEL1310110011#

metaR URIK1
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110011#
name: uridine kinase (ATP:Uridine)
product: MODEL1310110011#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.48
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
fast: false

metaR GluForTx
kinetic law: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
is: SBO:0000176
reversible: false
product: MODEL1310110011#
name: Glutamate formimidoyltransferase
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
is version of: http://identifiers.org/ec-code/2.1.2.5
is described by: ECO:0000269

metaR r2506
fast: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110011#_97045705_c5a6_4eab_95f1_9c7c401f0bae
initial amount: NaN
name: PRODH2
is: SBO:0000252
is encoded by: hsa:58510
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: Q9UF12
has only substance units: false

metaR LEUKTRA4t
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
is described by: ECO:0000269
name: leukotriene A4 transport
product: MODEL1310110011#
fast: false

metaM atp x
name: ATP(4-)
is: CHEBI:57299
is: HMDB00538
has only substance units: false
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: C00002
is: SBO:0000247
initial concentration: 1.0

metaR LGNCt
is: SBO:0000185
product: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110011#
name: fatty acid transport via diffusion
reversible: true

metaR r2382
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110011#
modifier: MODEL1310110011#
reversible: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_a48ea043_0870_47bc_8fa8_d33c0d83c1a4
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: _BE042354_1_m
type: Species
is encoded by: hsa:BE042354
has only substance units: false
boundary condition: true

metaM ach n
initial amount: NaN
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:15355
is: HMDB00895
name: acetylcholine
initial concentration: 1.0

metaM thmpp c
is: SBO:0000247
constant: false
initial concentration: 1.0
is: C00068
type: Species
boundary condition: false
is: CHEBI:45931
name: Thiamine diphosphate
is: HMDB01372
has only substance units: false
initial amount: NaN
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068

metaM lys L e
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: L-lysinium(1+)
type: Species
constant: false
is: CHEBI:32551
is: SBO:0000247
boundary condition: false
is: HMDB00182
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047

metaR ALR2
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.21
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.1.2
name: aldose reductase (methylglyoxal)
type: Reaction
product: MODEL1310110011#

metaR HMGCOARc
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
product: MODEL1310110011#
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.34
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
kinetic law: MODEL1310110011#
reversible: false
modifier: MODEL1310110011#
reactant: MODEL1310110011#
fast: false

metaM hxcoa c
name: Hexanoyl-CoA (n-C6:0CoA)
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
type: Species
is: HMDB13130
initial amount: NaN

metaR EX aprgstrn LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 20alpha-Hydroxyprogesterone exchange
type: Reaction

metaR r0720
kinetic law: MODEL1310110011#
fast: false
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
product: MODEL1310110011#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_67985792_d900_4df7_a8d7_e5abc30ab956
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
name: PC
is encoded by: hsa:5091
has only substance units: false
constant: false
is: P11498
boundary condition: true

metaR C60CPT1
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexanoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_f973ce20_e8fe_4b48_a2b0_1292575292a0
type: Species
initial amount: NaN
constant: false
name: TPI1
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:7167
is: SBO:0000252
is: Q53HE2

http://identifiers.org/biomodels.db/MODEL1310110011#_b86d5238_c154_4fc7_9969_6c17ab3a7ef3
is: Q9HAW8
has only substance units: false
constant: false
type: Species
boundary condition: true
name: UGT1A10
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:54575
initial concentration: NaN

metaR r0584
is: SBO:0000176
product: MODEL1310110011#
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
reversible: true
kinetic law: MODEL1310110011#
fast: false
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_508c28c1_6d9c_4b01_91d5_1d60c329fc33
is: SBO:0000252
is: Q8NE62
is encoded by: hsa:55349
constant: false
type: Species
initial amount: NaN
has only substance units: false
name: CHDH
initial concentration: NaN
boundary condition: true

metaR FACOAL161
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase (hexadecenoate)
type: Reaction
kinetic law: MODEL1310110011#
reversible: true
fast: false
product: MODEL1310110011#
modifier: MODEL1310110011#
is: SBO:0000176
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_746f9dc0_59f0_4aea_bf8f_aaa228d3b2b6
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5959
is: Q92781
is: SBO:0000252
name: RDH5
boundary condition: true
constant: false

metaR Htx
reactant: MODEL1310110011#
fast: false
name: H transporter, peroxisome
is: SBO:0000185
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
reversible: true

metaR r2508
reversible: true
reactant: MODEL1310110011#
name: Utilized transport
product: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
kinetic law: MODEL1310110011#
is: SBO:0000185

metaM gchola x
has only substance units: false
notes: FORMULA: C26H43NO6 CHARGE: 0 INCHI: InChI=1S/C26H43NO6/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33)/p-1/t14-,15+,16-,17-,18+,19+,20-,21+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
is: SBO:0000247
is: CHEBI:58235
boundary condition: false
name: glycocholate
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: HMDB00138

http://identifiers.org/biomodels.db/MODEL1310110011#_138eb24d_a6bc_4f0a_bcf3_1a22162d7607
is encoded by: hsa:50
initial concentration: NaN
is: Q99798
has only substance units: false
name: ACO2
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false

metaM thcholstoic m
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:18402
boundary condition: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
type: Species
is: HMDB03873
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_92ccddb4_f489_477f_b6f4_3f33b21952b4
is: SBO:0000252
name: _AF116616_1_m
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AF116616
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_fba85876_207a_4cb6_a91f_d29a56db4d29
constant: false
name: PDE9A
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:5152

metaR r2388
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110011#
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_204ca900_80e4_4ac1_831b_10ea27b2c0aa
name: ELOVL5
boundary condition: true
initial amount: NaN
is encoded by: hsa:60481
is: F6SH78
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR AG13T10g
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110011#
fast: false
is: SBO:0000176
product: MODEL1310110011#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
kinetic law: MODEL1310110011#
is described by: ECO:0000000
reactant: MODEL1310110011#

metaR r2507
reversible: true
is described by: ECO:0000000
name: Utilized transport
product: MODEL1310110011#
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110011#

metaM glx c
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
name: glyoxylate
initial concentration: 1.0
is: CHEBI:36655
is: HMDB00119
has only substance units: false

metaM lys L c
name: L-lysinium(1+)
initial amount: NaN
is: CHEBI:32551
constant: false
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
has only substance units: false
is: HMDB00182

metaM nadh m
name: Nicotinamide adenine dinucleotide - reduced
is: SBO:0000247
type: Species
is: CHEBI:57945
constant: false
initial amount: NaN
is: HMDB01487
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3306
is: C00004

metaR STRDNCt
name: fatty acid transport via diffusion
fast: false
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000185
reversible: true
type: Reaction

metaR TTDCAtr
reactant: MODEL1310110011#
product: MODEL1310110011#
type: Reaction
reversible: true
kinetic law: MODEL1310110011#
is described by: ECO:0000269
fast: false
is: SBO:0000185
name: tetradecanoate (transport)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:

metaR r0899
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
name: Amino acid transporter ATB0+ Facilitated diffusion
is described by: ECO:0000000
reactant: MODEL1310110011#
is: SBO:0000185
kinetic law: MODEL1310110011#
product: MODEL1310110011#

metaR LPCOXp
is described by: ECO:0000269
name: L-pipecolate oxidase, peroxisomal
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.5.3.1
type: Reaction
product: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
is: SBO:0000176
modifier: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_d34095f3_b112_4023_8a3c_5a5cdf3a6b9c
name: LDHC
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:3948
initial concentration: NaN
constant: false
is: SBO:0000252
is: P07864
type: Species

metaR r2387
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110011#
kinetic law: MODEL1310110011#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
type: Reaction
reversible: false
modifier: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000000
fast: false

metaR DUDPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110011#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000185
name: dUDP nuclear transport

metaR r0587
modifier: MODEL1310110011#
type: Reaction
reversible: true
kinetic law: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000176
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1

http://identifiers.org/biomodels.db/MODEL1310110011#_b062928e_85e2_4192_a9b0_2b30233adfa6
name: SDR16C5
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:195814
initial amount: NaN
type: Species
is: B3KT84
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_51d00580_5204_45bd_9482_e114fc60612b
initial amount: NaN
is: Q96P26
initial concentration: NaN
constant: false
has only substance units: false
name: NT5C1B
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:93034

http://identifiers.org/biomodels.db/MODEL1310110011#_1a35ee56_371b_4558_ba2e_eb137ca10457
type: Species
is encoded by: hsa:204
name: AK2
initial amount: NaN
is: P54819
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaM dgchol x
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
name: glycochenodeoxycholate
is: CHEBI:36252
initial amount: NaN
is: SBO:0000247
is: HMDB00637
constant: false
type: Species

metaM ficytC m
constant: false
initial concentration: 1.0
initial amount: NaN
name: Ferricytochrome c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
type: Species
has only substance units: false
is: CHEBI:15991

metaR r2386
product: MODEL1310110011#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reactant: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR FRDPtr
is: SBO:0000185
product: MODEL1310110011#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110011#
fast: false
type: Reaction
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_afa4a365_1bab_484e_a022_c63aeba12d2e
name: _T83654_1_m
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:T83654

metaR DNDPt16m
name: dUDP transport via dADP antiport
reactant: MODEL1310110011#
product: MODEL1310110011#
reversible: false
type: Reaction
modifier: MODEL1310110011#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185

metaR HOCTDECCRNe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyoctadecanoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_4f0056c6_4267_4745_85f3_d4fc9c1bdaab
name: SLC6A2
type: Species
initial amount: NaN
is: Q96KH8
is encoded by: hsa:6530
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM srtn c
type: Species
initial concentration: 1.0
is: HMDB00259
is: CHEBI:350546
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
constant: false
is: SBO:0000247
initial amount: NaN
name: serotonin(1+)
has only substance units: false
boundary condition: false

metaR r2509
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction
name: Utilized transport
product: MODEL1310110011#
reversible: true
fast: false

metaM prostgf2 e
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
constant: false
type: Species
is: HMDB01139
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: prostaglandin F2alpha(1-)
is: CHEBI:57404

http://identifiers.org/biomodels.db/MODEL1310110011#_08f43933_2c00_4159_97e2_a7877fa6ebe9
name: _M68895_1_c
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:M68895
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true

metaM chol e
is: C00114
name: Choline
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00097
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial amount: NaN
is: CHEBI:15354
type: Species
constant: false
is: SBO:0000247

metaR F6Tg
is described by: ECO:0000000
product: MODEL1310110011#
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.4.1.68
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
fast: false
reversible: false
is: SBO:0000176
reactant: MODEL1310110011#
type: Reaction
name: glycoprotein 6-alpha-L-fucosyltransferase

metaR r2385
product: MODEL1310110011#
is: SBO:0000185
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110011#
modifier: MODEL1310110011#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
is described by: ECO:0000000

metaR PROSTGE2t
fast: false
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
name: prostaglandin transport via bicarbonate countertransport
modifier: MODEL1310110011#
product: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#
reversible: true
is: SBO:0000185
is described by: ECO:0000269

metaM CE5236 n
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: O2'-4a-cyclic-tetrahydrobiopterin
is: CHEBI:28002
boundary condition: false
constant: false
is: HMDB03952

metaR FAOXC2442246x
reversible: false
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c24:4,n-6 -> c22:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
product: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107

metaM gdpfuc g
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
constant: false
boundary condition: false
initial concentration: 1.0
name: GDP-L-fucose(2-)
is: CHEBI:57984
initial amount: NaN
is: HMDB01095
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_d826e551_67ff_4b4e_b5fa_fde0a9b0c7d4
is encoded by: hsa:2678
is: P19440
boundary condition: true
constant: false
type: Species
has only substance units: false
name: GGT1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR RE1526M
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110011#
is described by: ECO:0000000
name: RE1526
reversible: true
kinetic law: MODEL1310110011#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
modifier: MODEL1310110011#
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_856d3ba5_b0f7_4b93_9ed8_61895009e765
type: Species
is: SBO:0000252
initial amount: NaN
name: ABCA1
constant: false
has only substance units: false
is: O95477
boundary condition: true
is encoded by: hsa:19
initial concentration: NaN

metaR r1820
fast: false
is described by: ECO:0000000
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
modifier: MODEL1310110011#
product: MODEL1310110011#

metaR r1933
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110011#
is: SBO:0000185
reversible: false
reactant: MODEL1310110011#
product: MODEL1310110011#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_b0d44465_bb41_4071_aa4f_fb0badbe2415
initial amount: NaN
is encoded by: hsa:AL525798
name: _AL525798_1_c
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_de5b6455_f818_4374_a887_c42ac5785af5
has part: Q8NBL9
is encoded by: hsa:10026
has only substance units: false
constant: false
boundary condition: true
has part: Q969N2
has part: O43292
name: PIGK:PIGU:PIGT:GPAA1:PIGS
has part: Q9H490
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:94005
is: SBO:0000297
is encoded by: hsa:51604
is encoded by: hsa:8733
is encoded by: hsa:128869
has part: Q92643
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_c289fa77_77d3_43a1_b58e_8486fdde0d6d
constant: false
is: Q02153
name: GUCY1B3
type: Species
boundary condition: true
is encoded by: hsa:2983
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR FAOXC180
is described by: ECO:0000269
product: MODEL1310110011#
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
modifier: MODEL1310110011#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR MECOALm
modifier: MODEL1310110011#
type: Reaction
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176
fast: false
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/6.2.1.5
is described by: ECO:0000212
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#

metaM leuktrA4 r
type: Species
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
has only substance units: false
initial concentration: 1.0
name: leukotriene A4(1-)
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:57463
constant: false
is: HMDB01337

metaR MG1er
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
kinetic law: MODEL1310110011#
reversible: false
modifier: MODEL1310110011#
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.2.1.106
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110011#

metaR r1934
is: SBO:0000185
type: Reaction
reactant: MODEL1310110011#
fast: false
reversible: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110011#
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000000

metaR PAPtg
is described by: ECO:0000000
kinetic law: MODEL1310110011#
fast: false
name: adenosine 3',5'-bisphosphate Golgi transport
reversible: false
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000185
reactant: MODEL1310110011#

metaM hdcecrn c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
has only substance units: false
boundary condition: false
constant: false
name: Hexadecenoyl carnitine
type: Species
is: SBO:0000247
is: HMDB00222

metaR UMPK4n
reactant: MODEL1310110011#
name: UMP kinase (GTP),nuclear
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is: SBO:0000176
modifier: MODEL1310110011#
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000269

metaR DNDPt33m
is described by: ECO:0000269
is: SBO:0000185
fast: false
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
product: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
name: dGDP transport via dUDP antiport

metaM bildglcur c
is: HMDB03325
is: CHEBI:58471
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
name: bis(beta-glucosyluronate)bilirubin
initial amount: NaN

metaR NDPK10
modifier: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
is: SBO:0000176
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dIDP)

metaR LPS2e
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.1.1.3
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.3 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:carbonyl and extra H accounted for in R group NJ
fast: false
is: SBO:0000176
modifier: MODEL1310110011#
is described by: ECO:0000000
product: MODEL1310110011#
reversible: false
reactant: MODEL1310110011#
type: Reaction
name: lipase, extracellular

metaM thmpp m
initial concentration: 1.0
name: Thiamine diphosphate
has only substance units: false
is: CHEBI:45931
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 INCHI: InChI=1S/C12H18N4O7P2S/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21) HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01372

metaR ACCOAtn
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110011#
is: SBO:0000185
kinetic law: MODEL1310110011#
fast: false
name: acetyl-CoA transport, nuclear
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110011#

metaM clpn hs c
is: SBO:0000247
boundary condition: false
is: CHEBI:15589
has only substance units: false
initial amount: NaN
notes: FORMULA: CHARGE: 0
name: clpn_hs[c]
is: HMDB00156
initial concentration: 1.0
type: Species
constant: false

metaR CRNt
reactant: MODEL1310110011#
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
name: L-carnitine reversible transport
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
reversible: true
fast: false

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaR VLCSp
modifier: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
fast: false
reversible: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
name: Very-long-chain-fatty-acid-CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
is described by: ECO:0000269

metaR r0022
is version of: http://identifiers.org/ec-code/1.8.1.7
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
modifier: MODEL1310110011#
is: SBO:0000176
reversible: true
reactant: MODEL1310110011#
product: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_93bd6c4f_ae53_4b6f_8abf_62b81a7ec6d0
has only substance units: false
constant: false
is encoded by: hsa:171425
name: CLYBL
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is: Q8N0X4

http://identifiers.org/biomodels.db/MODEL1310110011#_e8faa100_9bf2_4130_a02f_acebd3afd730
boundary condition: true
is: F5H123
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: DYLX2
type: Species
initial concentration: NaN
is encoded by: hsa:9856
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_b3cd8fb3_83c6_40d7_a1d8_d9058ce13b23
is: SBO:0000252
name: B4GALT2
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:8704
has only substance units: false
is: O60909
initial concentration: NaN

metaM L2aadp c
name: L-2-aminoadipate(1-)
initial amount: NaN
boundary condition: false
is: HMDB00510
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:58672
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956

metaM CE2839 e
has only substance units: false
is: C01936
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
constant: false
initial amount: NaN
name: maltodecaose
type: Species
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
initial concentration: 1.0
boundary condition: false

metaR DM dgpi prot hs r
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dgpi prot hs(r)
type: Reaction

metaR RE3006M
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE3006
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110011#
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true

metaR ADKd
modifier: MODEL1310110011#
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.7.4.3
name: adenylate kinase (d form)
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
is: SBO:0000176
type: Reaction
fast: false

metaM 5adtststerone r
constant: false
is: HMDB02961
type: Species
is: CHEBI:16330
is: SBO:0000247
name: 17beta-hydroxy-5alpha-androstan-3-one
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false

metaM bildglcur e
has only substance units: false
constant: false
is: CHEBI:58471
boundary condition: false
name: bis(beta-glucosyluronate)bilirubin
initial amount: NaN
is: HMDB03325
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787

http://identifiers.org/biomodels.db/MODEL1310110011#_26ad2fc9_8cc9_418b_912f_fd9aa462db06
initial amount: NaN
is: SBO:0000252
is: Q99707
is encoded by: hsa:4548
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
name: MTR
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_7aa7c21c_8cc3_4428_a8cc_9bc3c0884c29
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5091
is: SBO:0000252
initial amount: NaN
constant: false
name: PC

metaR EX tetdece1crn
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecenoyl carnitine
type: Reaction

metaR ACACT10m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
name: acetyl-CoA C-acetyltransferase, mitochondrial
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.9
modifier: MODEL1310110011#
fast: false
type: Reaction
reversible: true
is described by: ECO:0000134
is: SBO:0000176

metaR DSAT
product: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
name: dihydrosphingosine N-acyltransferase
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110011#

metaR r0021
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
is version of: http://identifiers.org/ec-code/3.6.1.5
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is: SBO:0000176
modifier: MODEL1310110011#
reversible: true
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_b0e4ecd1_52c1_4c4a_ae68_0d4c79bd8786
type: Species
is: P30613
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:5313
boundary condition: true
name: PKLR

metaR ILETAm
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
name: isoleucine transaminase, mitochondrial
kinetic law: MODEL1310110011#
reversible: true
is: SBO:0000176
modifier: MODEL1310110011#
type: Reaction
fast: false
is described by: ECO:0000269

metaR GLCNACT L
is described by: ECO:0000000
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (liver)
product: MODEL1310110011#

metaM gdpfuc c
has only substance units: false
constant: false
is: CHEBI:57984
is: HMDB01095
name: GDP-L-fucose(2-)
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
type: Species

metaM thcholstoic x
type: Species
is: CHEBI:18402
initial concentration: 1.0
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
has only substance units: false
is: HMDB03873
is: SBO:0000247
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_5aa16ebd_5060_44df_8414_b5924d0611b7
has only substance units: false
initial concentration: NaN
name: _AI091231_1_c
is encoded by: hsa:AI091231
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_4d85feee_bc8f_4cbc_8307_f325ebc5f65a
boundary condition: true
name: _BE966236_1_m
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:BE966236
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR FAOXC2242046m
is: SBO:0000176
modifier: MODEL1310110011#
product: MODEL1310110011#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
reactant: MODEL1310110011#
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110011#
type: Reaction

metaM aprgstrn e
type: Species
initial concentration: 1.0
is: HMDB03069
initial amount: NaN
name: (20S)-20-hydroxypregn-4-en-3-one
is: SBO:0000247
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042
has only substance units: false
is: CHEBI:28453
constant: false
boundary condition: false

metaM ps hs c
constant: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial amount: NaN
type: Species
name: ps_hs[c]
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:18303

metaR CHSTEROLt3
reactant: MODEL1310110011#
product: MODEL1310110011#
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
name: cholesterol intracellular transport

metaM 3octdectecoa m
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB06294
has only substance units: false
name: 3,6,9,12-octadecatetraenoylcoa
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
boundary condition: false
type: Species

metaR PTPAT
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.3
kinetic law: MODEL1310110011#
is described by: ECO:0000269
name: Phosphopantetheine adenylyltransferase (EC 2.7.7.3)
fast: false
reversible: true
reactant: MODEL1310110011#
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110011#

metaR r0892
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.27
modifier: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
reactant: MODEL1310110011#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
name: Facilitated diffusion

metaR GLCNACPT L
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: false
product: MODEL1310110011#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.8.15
is described by: ECO:0000000
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (liver)
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
fast: false
reactant: MODEL1310110011#

metaM m8masn g
is: C05876
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C70H117N2O55X CHARGE: 0
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false
is: SBO:0000247
constant: false

metaM mal L m
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB00156
type: Species
constant: false
is: CHEBI:15589
is: SBO:0000247
name: (S)-malate(2-)
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
boundary condition: false

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaR CHSTEROLt2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
name: cholesterol intracellular transport
is: SBO:0000185
reactant: MODEL1310110011#
is described by: ECO:0000000
product: MODEL1310110011#
type: Reaction
fast: false
kinetic law: MODEL1310110011#

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaM hmgcoa x
name: Hydroxymethylglutaryl-CoA
is: CHEBI:15467
boundary condition: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
type: Species
constant: false
is: HMDB01375
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR r1935
kinetic law: MODEL1310110011#
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110011#
modifier: MODEL1310110011#
reversible: false
fast: false
product: MODEL1310110011#
is described by: ECO:0000000

metaM acrn x
type: Species
initial amount: NaN
is: HMDB00201
name: O-acetylcarnitine
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57589
initial concentration: 1.0

metaR ACNAMPH
product: MODEL1310110011#
is: SBO:0000176
name: N-Acetylneuraminate 9-phosphate phosphohydrolase
type: Reaction
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110011#
fast: false
is described by: ECO:0000000
reversible: false

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaR CO2t
fast: false
product: MODEL1310110011#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
name: CO2 transporter via diffusion
is: SBO:0000185
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#

metaM 6dhf e
name: hexaglutamyl folate (DHF)
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
boundary condition: false
is: HMDB06563
type: Species
constant: false
initial amount: NaN

metaR CHSTEROLt1
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
is: SBO:0000185
reactant: MODEL1310110011#
modifier: MODEL1310110011#
product: MODEL1310110011#
reversible: true
fast: false
kinetic law: MODEL1310110011#
is described by: ECO:0000304
name: cholesterol intracellular transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_57607eb3_f9c5_41aa_86dd_28354f1861f2
boundary condition: true
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is: O94788
name: ALDH1A2
initial amount: NaN
is encoded by: hsa:8854

http://identifiers.org/biomodels.db/MODEL1310110011#_3559c184_86a7_447b_b42e_4249ec0dea76
initial amount: NaN
initial concentration: NaN
name: TK2
type: Species
boundary condition: true
is encoded by: hsa:7084
is: SBO:0000252
has only substance units: false
constant: false
is: O00142

metaR GLXO1
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (3939.1) or (55293.1) or (3945.1 and 3939.1) or (197257.1) or (92483.1) or (3945.1) or (160287.1) or (3948.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.3.5 Confidence Level: 4 AUTHORS: PMID:12768081,PMID:9038835,PMID:9604807,PMID:9783918 NOTES:NCD
product: MODEL1310110011#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.27
fast: false
is: SBO:0000176
name: glyoxylate oxidase
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.2.4
reactant: MODEL1310110011#

metaM 3ttetddcoa c
initial amount: NaN
name: 3-hydroxy trans5,8tetradecadienoyl coa
boundary condition: false
is: SBO:0000247
type: Species
constant: false
has only substance units: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
initial concentration: 1.0
is: HMDB02014

metaR r1936
type: Reaction
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
modifier: MODEL1310110011#
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport

metaM gdpddman c
is: CHEBI:57964
initial concentration: 1.0
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
initial amount: NaN
is: HMDB01346
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222
has only substance units: false
boundary condition: false

metaR r1400
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
reactant: MODEL1310110011#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
name: Active transport
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: false

metaR M13N2Tg
is: SBO:0000176
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
product: MODEL1310110011#
modifier: MODEL1310110011#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.101
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110011#
reversible: false
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
reactant: MODEL1310110011#

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_5df34baa_5f6e_4b99_b049_f2ac713d51b7
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
name: _AI469183_1_x
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI469183

http://identifiers.org/biomodels.db/MODEL1310110011#_6bde475b_f795_491d_b286_d3b00f4ba862
constant: false
is: SBO:0000252
is encoded by: hsa:6576
boundary condition: true
is: D9HTE9
name: SLC25A1
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_748b3c06_a3c3_4598_9e41_ae733b730a8b
name: MBOAT2
boundary condition: true
type: Species
is encoded by: hsa:129642
has only substance units: false
is: Q6ZWT7
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN

metaR r0170
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.40
product: MODEL1310110011#
is: SBO:0000176
reactant: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#
fast: false
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
reversible: true

metaM ribflv c
is: CHEBI:3554
name: Riboflavin
is: C00255
constant: false
type: Species
initial amount: NaN
is: HMDB00244
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
boundary condition: false
is: SBO:0000247

metaR FAOXC163C164Gm
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

metaR r1401
type: Reaction
is described by: ECO:0000000
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.10.1
is version of: http://identifiers.org/ec-code/2.3.1.41
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.51
modifier: MODEL1310110011#
is: SBO:0000185
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.3
is version of: http://identifiers.org/ec-code/3.2.1.35
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
name: Facilitated diffusion

http://identifiers.org/biomodels.db/MODEL1310110011#_22f9d78c_c661_43ed_b699_2fc97dde3f7a
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3612
initial concentration: NaN
is: B7Z6Q4
name: IMPA1
constant: false
type: Species
has only substance units: false

metaR GGT5r
name: Gamma-glutamyltransferase 5
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.2.2
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (2687.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:18357468,PMID:18357469,PMID:6120203 NOTES:Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). NJ
product: MODEL1310110011#
fast: false
is: SBO:0000176
type: Reaction
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110011#

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaR GGH 10FTHF6GLUe
reversible: false
kinetic law: MODEL1310110011#
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
fast: false
reactant: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110011#_98aaa48d_a538_4930_a0b6_5430bf76c9cb
constant: false
is encoded by: hsa:BC005314
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: _BC005314_1_x
has only substance units: false

metaR RE1836X
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.176
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000176
name: RE1836
reversible: true
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
is described by: ECO:0000000
product: MODEL1310110011#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_6e0ed650_1923_4a9d_a17f_62a434c77915
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: _AA081045_1_c
is encoded by: hsa:AA081045
constant: false
boundary condition: true
type: Species
has only substance units: false

metaM lys L x
is: CHEBI:32551
is: HMDB00182
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
name: L-lysinium(1+)
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_228aa4e5_cb02_4623_bd43_badf299612ba
is: P52789
constant: false
name: HK2
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3099
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_8464f606_bc2c_4647_b05b_67212bb62978
constant: false
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: SLC17A2
is encoded by: hsa:10246
is: O00624
initial concentration: NaN

metaM L2aadp m
is: HMDB00510
type: Species
is: SBO:0000247
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: CHEBI:58672
initial amount: NaN
constant: false
name: L-2-aminoadipate(1-)
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaM h g
type: Species
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
boundary condition: false
is: CHEBI:24636
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN

metaM glx x
has only substance units: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
constant: false
type: Species
initial concentration: 1.0
name: glyoxylate
is: HMDB00119
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:36655

http://identifiers.org/biomodels.db/MODEL1310110011#_e911d000_f22c_4c8a_a003_44b6e66a6951
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
type: Species
is: Q5SYN6
has only substance units: false
name: SLC22A3
is encoded by: hsa:6581

metaM ribflv e
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: CHEBI:3554
is: C00255
constant: false
name: Riboflavin
type: Species
initial amount: NaN
is: HMDB00244
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_f7d8982d_585f_4875_a8b4_ecd7ae594af2
constant: false
is: Q06830
boundary condition: true
has only substance units: false
initial amount: NaN
name: PRDX1
is encoded by: hsa:5052
is: SBO:0000252
initial concentration: NaN
type: Species

metaM lac D c
initial concentration: 1.0
is: CHEBI:16004
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB01311
initial amount: NaN
name: (R)-lactate

metaM 2pg c
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: 1/C3H7O7P/c4-1-2(3(5)6)10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/t2-/m1/s1/f/h5,7-8H HEPATONET_1.0_ABBREVIATION: HC00463 EHMN_ABBREVIATION: C00631
name: D-Glycerate 2-phosphate
initial amount: NaN
constant: false
is: HMDB03391
boundary condition: false
is: C00631
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3904
is: CHEBI:58289

http://identifiers.org/biomodels.db/MODEL1310110011#_a42b3ff1_c595_41a3_8b91_b8edf4cd466f
initial concentration: NaN
is encoded by: hsa:7371
boundary condition: true
type: Species
has only substance units: false
name: UCK2
is: Q9BZX2
initial amount: NaN
is: SBO:0000252
constant: false

metaM hmgcoa m
is: SBO:0000247
name: Hydroxymethylglutaryl-CoA
initial amount: NaN
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: CHEBI:15467
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB01375
constant: false
has only substance units: false

metaR MG2er
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
is: SBO:0000176
fast: false
reversible: false
is described by: ECO:0000000
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_0b089b9d_429b_4b72_8242_94749445b57e
type: Species
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:AA419122
initial concentration: NaN
initial amount: NaN
name: _AA419122_1_c
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_47e3bf88_f077_47e6_ba5f_7f5a125dddfa
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000297
boundary condition: true
name: ADH1B:ADH1C
constant: false
is encoded by: hsa:126
initial concentration: NaN
has part: P00326

metaM ksi pre23 g
name: keratan sulfate I biosynthesis, precursor 23
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:28067
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_63d18213_fd4d_444a_9aca_5aef200ee1e8
initial amount: NaN
boundary condition: true
is: P30519
is encoded by: hsa:3163
has only substance units: false
name: HMOX2
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false

metaR ORNt3m
modifier: MODEL1310110011#
type: Reaction
name: ornithine mitochondrial transport via proton antiport
is described by: ECO:0000269
kinetic law: MODEL1310110011#
product: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_241e6b00_66ce_43e3_ab8c_61ca58a5003b
has only substance units: false
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: O43286
is encoded by: hsa:9334
name: B4GALT5

metaM h e
notes: FORMULA: H CHARGE: 1 INCHI: "
is: C00080
constant: false
initial amount: NaN
boundary condition: false
name: proton
is: http://identifiers.org/pubchem.compound/3380
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:24636

metaM bilglcur r
type: Species
constant: false
name: mono(glucosyluronic acid)bilirubin(2-)
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57767
boundary condition: false
has only substance units: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374

metaR G14T8g
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
reactant: MODEL1310110011#
reversible: false
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22

http://identifiers.org/biomodels.db/MODEL1310110011#_a58565e3_55ab_42a9_bacf_5bb5b92816ca
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: SGPP2
is encoded by: hsa:130367
has only substance units: false
boundary condition: true
is: Q8IWX5

metaR PE HStm
is described by: ECO:0000000
is: SBO:0000185
name: phosphatidylethanolamine scramblase
kinetic law: MODEL1310110011#
product: MODEL1310110011#
fast: false
type: Reaction
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true

metaM lgnc c
type: Species
is: SBO:0000247
constant: false
is: HMDB02003
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:31014
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
name: lignocerate

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaR DOLPMT1 Ler
type: Reaction
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
modifier: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.258
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000176
is described by: ECO:0000000

metaR COQ3m
name: methyltransferase COQ3
kinetic law: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.1.1.114
fast: false
is described by: ECO:0000269
reactant: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10777520,PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_2.1.1.114 IT
reversible: false

metaR PGCD
is: SBO:0000176
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.1.1.95
kinetic law: MODEL1310110011#
name: phosphoglycerate dehydrogenase
product: MODEL1310110011#
is described by: ECO:0000269
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (26227.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
reversible: false
modifier: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_a05a5db0_c093_44ed_9281_23534a2889de
is encoded by: hsa:51227
is: SBO:0000297
is encoded by: hsa:5279
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:5277
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has part: B2RAU6
initial amount: NaN
initial concentration: NaN
has part: P57054
constant: false
is encoded by: hsa:9091

metaM HC00460 c
has only substance units: false
is: CHEBI:58044
name: 2,5-dihydroxybenzoate
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_dcd51604_272b_425d_8b44_f80af1e40776
initial concentration: NaN
has only substance units: false
constant: false
is: Q4KWH8
type: Species
is encoded by: hsa:23007
initial amount: NaN
boundary condition: true
name: PLCH1
is: SBO:0000252

metaM lac D e
type: Species
is: CHEBI:16004
name: (R)-lactate
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB01311

metaR CYTK11n
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reactant: MODEL1310110011#
product: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
name: cytidylate kinase (dCMP,dGTP),nuclear
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269

metaR r0434
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
type: Reaction
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110011#
fast: false
is: SBO:0000176
reactant: MODEL1310110011#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110011#_aef7b6a8_10e9_4bfd_bce4_33d969fb1c84
is encoded by: hsa:622
boundary condition: true
constant: false
name: BDH1
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM urate e
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
constant: false
is: SBO:0000247
is: HMDB00289
is: CHEBI:17775
has only substance units: false
boundary condition: false
is: C00366
name: Urate
type: Species
initial concentration: 1.0
initial amount: NaN

metaR r0173
product: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000176
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.6.1.19
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (3704.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:12042361,PMID:17045662,PMID:7449128,PMID:9927705 NOTES:
name: (S)-Lactate:NAD+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.1.1.27
fast: false

metaM ksi pre12 g
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
is: CHEBI:58053
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 12
constant: false
initial amount: NaN
is: C00130
boundary condition: false

metaM 3hmp m
is: HMDB00023
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
boundary condition: false
name: 3-hydroxy-2-methylpropanoate
type: Species
has only substance units: false
is: CHEBI:11805

metaM h c
is: C00080
is: SBO:0000247
initial amount: NaN
is: CHEBI:24636
name: proton
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: "
is: http://identifiers.org/pubchem.compound/3380
type: Species

metaR OCDCEAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
reversible: true
name: fatty acid transport via diffusion
reactant: MODEL1310110011#
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110011#
product: MODEL1310110011#

metaM co c
has only substance units: false
initial concentration: 1.0
is: CHEBI:17245
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
name: carbon monoxide
is: HMDB01361

metaR r0718
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
modifier: MODEL1310110011#
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.181
is: SBO:0000176
fast: false
type: Reaction
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211

metaR r0027
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.39
reactant: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
fast: false
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
kinetic law: MODEL1310110011#

metaM clpndcoa x
type: Species
name: clupanodonyl CoA
is: HMDB06267
constant: false
initial amount: NaN
is: SBO:0000247
is: C16166
is: http://identifiers.org/pubchem.compound/47205476
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
has only substance units: false
boundary condition: false

metaM lgnc e
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
name: lignocerate
is: SBO:0000247
is: HMDB02003
constant: false
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:31014

metaM hepcoa m
name: heptanoylcoa
is: SBO:0000247
is: HMDB12969
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C28H44N7O17P3S CHARGE: -4
boundary condition: false
type: Species
constant: false

metaR r0437
is described by: ECO:0000000
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is: SBO:0000176
reactant: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/4.1.2.13
product: MODEL1310110011#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110011#_83840739_2e9a_4f81_b1c9_020b2a699433
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
name: MECR
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:51102
is: Q9BV79

http://identifiers.org/biomodels.db/MODEL1310110011#_e106c7ca_0159_41f2_86d1_b59202f6a0a4
constant: false
name: CDIPT
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: A8K3L7
type: Species
is encoded by: hsa:10423
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_5f7777a6_a533_4f74_862d_dadaf8bf78d0
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P37287
name: PIGA
is encoded by: hsa:5277

metaR FAOXC163GC142m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_d6a7458a_a58d_49ed_a57c_d2444e66ccf2
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:5625
boundary condition: true
name: PRODH
has only substance units: false
initial amount: NaN
is: O43272

http://identifiers.org/biomodels.db/MODEL1310110011#_fbed948e_52fc_4230_a260_5dd122bdd295
boundary condition: true
name: SGPL1
initial concentration: NaN
is: O95470
initial amount: NaN
has only substance units: false
is encoded by: hsa:8879
constant: false
is: SBO:0000252
type: Species

metaM mal L e
is: SBO:0000247
name: (S)-malate(2-)
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
is: CHEBI:15589
constant: false
is: HMDB00156
type: Species

metaM urate c
is: SBO:0000247
constant: false
is: HMDB00289
is: C00366
boundary condition: false
type: Species
initial concentration: 1.0
name: Urate
is: CHEBI:17775
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366

metaM mal L c
is: CHEBI:15589
is: HMDB00156
initial amount: NaN
is: SBO:0000247
name: (S)-malate(2-)
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
type: Species
boundary condition: false
constant: false

metaR FAOXC15C13m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C15-->C13)m
type: Reaction

metaR MTHFCm
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.9
is described by: ECO:0000269
kinetic law: MODEL1310110011#
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.3
reversible: true
modifier: MODEL1310110011#
reactant: MODEL1310110011#
product: MODEL1310110011#

metaM h r
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
name: proton
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: C00080
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species

metaM retinal 11 cis c
is: HMDB02152
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
constant: false
is: CHEBI:16066
initial concentration: 1.0
name: 11-cis-retinal
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_cd094848_6101_4373_9c25_484bdf3f392c
initial amount: NaN
type: Species
constant: false
name: VNN3:VNN2:VNN1
is: SBO:0000297
has only substance units: false
boundary condition: true
is encoded by: hsa:55350
initial concentration: NaN

metaR FAOXC225C204m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaR MALtm
kinetic law: MODEL1310110011#
name: malate transport, mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
is: SBO:0000185
fast: false
product: MODEL1310110011#
is described by: ECO:0000269
reactant: MODEL1310110011#
modifier: MODEL1310110011#
reversible: true

metaM hom L c
constant: false
name: L-homoserine
initial amount: NaN
is: SBO:0000247
is: HMDB00719
is: CHEBI:15699
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial concentration: 1.0

metaM thyox L c
constant: false
is: CHEBI:18332
is: SBO:0000247
boundary condition: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
name: L-thyroxine
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00248

metaR ACGPID
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/3.5.1.89
kinetic law: MODEL1310110011#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110011#
name: N-acetylglucosaminylphosphatidylinositol deacetylase
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
reversible: false
fast: false
reactant: MODEL1310110011#
type: Reaction

metaR AG13T7g
is: SBO:0000176
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110011#
product: MODEL1310110011#
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110011#
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaM ura e
name: uracil
initial amount: NaN
is: CHEBI:17568
has only substance units: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB00300
constant: false
initial concentration: 1.0

metaM pentcoa m
name: pentanoylcoa
type: Species
constant: false
is: HMDB13037
is: C00888
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C26H40N7O17P3S CHARGE: -4

metaR r0998
is described by: ECO:0000000
kinetic law: MODEL1310110011#
reversible: true
type: Reaction
is: SBO:0000185
fast: false
name: Facilitated diffusion
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110011#

metaR MMMm
name: methylmalonyl-CoA mutase
is described by: ECO:0000269
fast: false
reactant: MODEL1310110011#
is: SBO:0000176
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/5.4.99.2
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#

metaR r0178
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
modifier: MODEL1310110011#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.21
reversible: true
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
is described by: ECO:0000000
fast: false
reactant: MODEL1310110011#
product: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_3b6ce1d0_c5b0_4244_89f0_b59df54a1aca
name: _AI480132_1_c
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:AI480132
initial concentration: NaN
constant: false
boundary condition: true

metaM datp n
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
initial concentration: 1.0
is: HMDB01532
is: C00131
constant: false
is: CHEBI:61404
type: Species
name: dATP
boundary condition: false

metaR DESAT18 6
fast: false
name: fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000176
type: Reaction

metaR CITt4 4
product: MODEL1310110011#
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000185
name: citrate transport via sodium symport
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
reversible: true
is described by: ECO:0000006

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaM bildglcur r
has only substance units: false
boundary condition: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
name: bis(beta-glucosyluronate)bilirubin
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB03325
is: CHEBI:58471
is: SBO:0000247

metaM o2 r
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
has only substance units: false
type: Species
name: O2
initial amount: NaN
is: HMDB01377
constant: false
initial concentration: 1.0
is: SBO:0000247
is: C00007
boundary condition: false
is: CHEBI:15379

metaM leuktrA4 c
constant: false
initial amount: NaN
is: HMDB01337
type: Species
is: CHEBI:57463
name: leukotriene A4(1-)
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR CSNATp
type: Reaction
fast: false
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
product: MODEL1310110011#
reversible: true
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.7
modifier: MODEL1310110011#
is described by: ECO:0000304

metaM for c
name: Formate
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00142
has only substance units: false
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: SBO:0000247
is: C00058
constant: false
is: CHEBI:15740

metaR DOLPMT2 Ler
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110011#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110011#
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110011#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)

metaM pcrn m
constant: false
name: propionyl-carnitine
initial concentration: 1.0
is: HMDB00824
has only substance units: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/107738
is: SBO:0000247
initial amount: NaN

metaM hom L e
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00719
is: CHEBI:15699
name: L-homoserine
type: Species
boundary condition: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
constant: false
has only substance units: false

metaR C10OHc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdecanoylcarnitinec
type: Reaction

metaM glyphe c
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: Glycylphenylalanine
type: Species
is: http://identifiers.org/pubchem.compound/97415
initial concentration: 1.0
notes: FORMULA: C11H14N2O3 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110011#_ee8758c9_36e6_4861_8406_b6d35c68dd89
constant: false
has only substance units: false
boundary condition: true
name: _AI990637_1_x
initial amount: NaN
is encoded by: hsa:AI990637
type: Species
initial concentration: NaN
is: SBO:0000252

metaR DM ethamp r
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_80d16c3d_09b2_4bb5_a9d9_9c71c092697f
name: ACSS2
has only substance units: false
constant: false
boundary condition: true
is: Q5QPH3
is encoded by: hsa:55902
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_d2c75d7f_f8d8_4bcd_8ce4_9294a10b4782
is encoded by: hsa:341947
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: Q7Z4L0
boundary condition: true
initial amount: NaN
constant: false
name: COX8C

http://identifiers.org/biomodels.db/MODEL1310110011#_983958d9_5ebd_44a1_a679_a3f4fc8b3312
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110011#_bec98525_d8fa_4c9c_af40_9fc1b2daf3a4
is: Q07326
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: PIGF
is: SBO:0000252
constant: false
is encoded by: hsa:5281
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_9f8b5974_2481_4a40_ba87_dca626cf5452
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: P49189
boundary condition: true
type: Species
name: ALDH9A1
initial amount: NaN
is encoded by: hsa:223
constant: false

metaR r0590
modifier: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
reversible: false
is described by: ECO:0000000

metaM adrncrn m
has only substance units: false
boundary condition: false
is: HMDB00062
is: C00318
type: Species
constant: false
notes: FORMULA: C29H49NO4 CHARGE: 0
is: CHEBI:16347
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: Adrenyl carnitine

metaM hmgcoa c
type: Species
is: HMDB01375
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
constant: false
initial amount: NaN
name: Hydroxymethylglutaryl-CoA
is: CHEBI:15467
boundary condition: false

metaM sucr e
type: Species
is: HMDB00258
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00091 EHMN_ABBREVIATION: C00089
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
name: Sucrose
is: C00089
is: CHEBI:17992

metaM leuktrA4 e
has only substance units: false
is: HMDB01337
type: Species
is: CHEBI:57463
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
name: leukotriene A4(1-)
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN

metaR ARACHt
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110011#
product: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
name: fatty acid transport via diffusion

metaR FAOXC123m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

metaR CSNATr
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
product: MODEL1310110011#
fast: false
name: carnitine O-acetyltransferase
reactant: MODEL1310110011#
is described by: ECO:0000000
kinetic law: MODEL1310110011#
is: SBO:0000176

metaR r0591
type: Reaction
is described by: ECO:0000000
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
modifier: MODEL1310110011#
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
fast: false

metaR DESAT22 1p
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110011#
reversible: false
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
fast: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_e81a623d_a428_45f3_bd0f_ba7390dce538
initial amount: NaN
type: Species
is: Q14117
constant: false
is encoded by: hsa:1807
has only substance units: false
boundary condition: true
name: DPYS
is: SBO:0000252
initial concentration: NaN

metaM 10fthf7glu e
type: Species
initial concentration: 1.0
name: 10-formyltetrahydrofolate-[Glu](7)
is: HMDB00972
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C50H57N13O25 CHARGE: -8
is: SBO:0000247
boundary condition: false
is: CHEBI:57454

metaM CE5854 e
initial concentration: 1.0
is: HMDB02710
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
is: CHEBI:27485
initial amount: NaN
type: Species
name: gama-CEHC-glucuronide

metaM 5adtststerone c
is: CHEBI:16330
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: HMDB02961
name: 17beta-hydroxy-5alpha-androstan-3-one
has only substance units: false
constant: false
type: Species
boundary condition: false
initial amount: NaN

metaR DRPA
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
reversible: false
is: SBO:0000176
type: Reaction
name: deoxyribose-phosphate aldolase
is described by: ECO:0000000
fast: false
reactant: MODEL1310110011#
product: MODEL1310110011#
kinetic law: MODEL1310110011#

metaR FAOXC16C14m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C14)m
type: Reaction

metaM urcan c
constant: false
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
type: Species
initial amount: NaN
is: SBO:0000247
name: Urocanate
is: C00785
is: CHEBI:17771
is: HMDB00301
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaM h n
name: proton
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:24636
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_5c3a65e7_eb4e_4b92_853f_fd6d30f5c965
is: O14986
type: Species
is encoded by: hsa:8395
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: PIP5K1B
constant: false

metaR PRO Dtde
is described by: ECO:0000134
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
name: D-proline transport, extracellular
reactant: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
kinetic law: MODEL1310110011#

metaR UDPGALtg
type: Reaction
kinetic law: MODEL1310110011#
product: MODEL1310110011#
modifier: MODEL1310110011#
name: UDP-Gal Golgi transport via CMP antiport
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
reversible: true
is: SBO:0000185
is described by: ECO:0000269
fast: false

metaR FAOXC11C9m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C11-->C9)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_60c359b1_44f4_40d5_a6c3_1d09a4512e8e
type: Species
boundary condition: true
has only substance units: false
name: CHST6
is: Q9GZX3
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4166
initial amount: NaN
constant: false

metaR r0994
fast: false
name: Facilitated diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
type: Reaction
reactant: MODEL1310110011#
reversible: true
is: SBO:0000185
product: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_282a6561_923b_44ea_914d_b2680320972a
initial amount: NaN
is encoded by: hsa:6534
has only substance units: false
name: SLC6A7
type: Species
initial concentration: NaN
is: Q99884
is: SBO:0000252
constant: false
boundary condition: true

metaM h m
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
has only substance units: false
initial concentration: 1.0
name: proton
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:24636
is: C00080
constant: false

metaR RE0830C
is: SBO:0000176
fast: false
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
name: RE0830
type: Reaction
product: MODEL1310110011#
reversible: true

metaM o2 x
initial amount: NaN
has only substance units: false
name: O2
type: Species
is: CHEBI:15379
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
is: C00007
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_aa543ecb_2d78_4729_8207_a69c218eeb1b
has only substance units: false
is encoded by: hsa:376497
boundary condition: true
type: Species
name: SLC27A1
is: Q6PCB7
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN

metaR FACOAL140i
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
reactant: MODEL1310110011#
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110011#
fast: false
is: SBO:0000176
type: Reaction
name: fatty-acid--CoA ligase (tetradecanoate)

metaM 5adtststerone e
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB02961
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
constant: false
initial amount: NaN
name: 17beta-hydroxy-5alpha-androstan-3-one
has only substance units: false
type: Species
is: CHEBI:16330

http://identifiers.org/biomodels.db/MODEL1310110011#_8a22a99f_7275_481c_ba5f_d10b0a9835e3
is: O43280
name: TREH
initial concentration: NaN
boundary condition: true
is encoded by: hsa:11181
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_e8904142_83e8_4630_ad9a_5607afcc54c6
is encoded by: hsa:5281
name: PIGF:PIGO
constant: false
initial concentration: NaN
initial amount: NaN
has part: Q8TEQ8
is: SBO:0000297
has only substance units: false
is encoded by: hsa:84720
has part: Q07326
boundary condition: true
type: Species

metaR r0179
is version of: http://identifiers.org/ec-code/1.1.1.27
kinetic law: MODEL1310110011#
is: SBO:0000176
modifier: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
fast: false
reversible: true
product: MODEL1310110011#
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_9f8332a6_1cf7_4557_90eb_4621278a16e2
is: Q15274
initial amount: NaN
is encoded by: hsa:23475
is: SBO:0000252
initial concentration: NaN
name: QPRT
has only substance units: false
type: Species
boundary condition: true
constant: false

metaM thyox L e
constant: false
is: CHEBI:18332
is: SBO:0000247
type: Species
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
name: L-thyroxine
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00248

http://identifiers.org/biomodels.db/MODEL1310110011#_731fb24a_3882_446a_bebe_9a6d99b3d2dd
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: true
is: P00352
is: SBO:0000252
name: ALDH1A1
is encoded by: hsa:216

metaM 3odcoa m
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
boundary condition: false
is: HMDB03939
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
name: 3-Oxodecanoyl-CoA
initial concentration: 1.0
is: CHEBI:28528
type: Species

metaR r0594
reversible: true
is: SBO:0000176
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
type: Reaction
product: MODEL1310110011#
is described by: ECO:0000000
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31

metaR r0441
modifier: MODEL1310110011#
reactant: MODEL1310110011#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
product: MODEL1310110011#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.40
is: SBO:0000176
fast: false

metaM dcmp c
is: SBO:0000247
is: CHEBI:57566
constant: false
name: dCMP
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: C00239
initial amount: NaN
is: HMDB01202
type: Species

metaM ura c
has only substance units: false
initial amount: NaN
is: CHEBI:17568
is: SBO:0000247
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: HMDB00300
type: Species
name: Uracil
initial concentration: 1.0
boundary condition: false
is: C00106
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_2fb652e8_4738_4a09_8ebc_2b4b5c537001
is: P22413
initial concentration: NaN
is encoded by: hsa:5167
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: ENPP1
boundary condition: true

metaM 3hddcoa c
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB00623
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
boundary condition: false
initial amount: NaN
name: (S)-3-Hydroxydodecanoyl-CoA
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_e6aa706a_0ce4_481d_8664_eb1c069f8770
is: A6NFM2
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:5831
has only substance units: false
name: PYCR1

http://identifiers.org/biomodels.db/MODEL1310110011#_f3f2e363_1b01_47f3_9689_842f914bad9a
initial amount: NaN
type: Species
boundary condition: true
is: B3KU59
is: SBO:0000252
name: SLC8A3
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6547
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_d2026835_73cd_4f58_bd41_a4a283863e9b
has only substance units: false
name: GNE
initial amount: NaN
constant: false
is: B7Z428
is encoded by: hsa:10020
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM dhor S c
has only substance units: false
initial amount: NaN
name: (S)-dihydroorotate
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:30864
is: HMDB03349
is: SBO:0000247
constant: false
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285

http://identifiers.org/biomodels.db/MODEL1310110011#_ecd53db7_387f_4ea6_b6b8_0d75d75be1d9
name: SLC35D1
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:23169
constant: false
boundary condition: true
initial amount: NaN
is: Q9NTN3
is: SBO:0000252

metaR BILIRED
is: SBO:0000176
reactant: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.1.24
type: Reaction
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
reversible: false
name: Nad(p)h biliverdin reductase
product: MODEL1310110011#
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110011#_f4b97abf_f54e_426f_b363_00319eb768de
is encoded by: hsa:5051
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is: Q99487
name: PAFAH2
boundary condition: true
has only substance units: false
initial amount: NaN

metaR RE0830N
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
product: MODEL1310110011#
type: Reaction
name: RE0830
reversible: true
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
is described by: ECO:0000000
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_f7f9e54b_0d43_42a3_9208_2757b2e6c78e
type: Species
is encoded by: hsa:93183
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000297
name: PIGX:PIGM
has part: Q9H3S5
initial amount: NaN
has part: Q8TBF5
constant: false
is encoded by: hsa:54965

http://identifiers.org/biomodels.db/MODEL1310110011#_ff600a0b_7dee_486e_b192_1afc5040ddae
name: PPA2
boundary condition: true
has only substance units: false
is: Q9H2U2
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:27068
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_fa15d88c_29e8_4a27_84ea_5ec247eb8050
initial amount: NaN
is encoded by: hsa:55902
is: Q5QPH3
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
name: ACSS2

http://identifiers.org/biomodels.db/MODEL1310110011#_2205a2bc_ee80_4cfc_acbd_f83de21d4fe6
is: Q9UJM8
constant: false
name: HAO1
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:54363

metaM 34hpl m
is: CHEBI:36659
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8,10-11H,5H2,(H,12,13)/p-1
name: 3-(4-hydroxyphenyl)lactate
type: Species
has only substance units: false
constant: false
is: HMDB00755
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM HC02205 c
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
is: SBO:0000247
has only substance units: false
name: prostaglandin-b2
is: CHEBI:28099
constant: false

metaM ksii core2 pre9 g
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 9
has only substance units: false
constant: false
is: CHEBI:28067
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_f4037d16_ebfb_40dd_b987_a2b2d1f74886
constant: false
boundary condition: true
type: Species
is encoded by: hsa:AI291895
name: _AI291895_1_c
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_934cd11b_864a_4c50_9989_bdbad35abcf9
type: Species
is: Q9P0Z9
has only substance units: false
name: PIPOX
boundary condition: true
initial concentration: NaN
is encoded by: hsa:51268
is: SBO:0000252
initial amount: NaN
constant: false

metaR r0885
is: SBO:0000185
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.38
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
product: MODEL1310110011#
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110011#

metaR EX c51crn
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

metaM dcyt c
constant: false
is: C00881
is: SBO:0000247
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial amount: NaN
is: HMDB00014
name: Deoxycytidine
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:15698
has only substance units: false

metaR r0596
reactant: MODEL1310110011#
is: SBO:0000176
product: MODEL1310110011#
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
kinetic law: MODEL1310110011#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4

metaR TTDCPT1
fast: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1374.1) or (1375.2) or (126129.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction
product: MODEL1310110011#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.21

metaM dcmp n
is: CHEBI:57566
initial amount: NaN
is: SBO:0000247
type: Species
name: dCMP(2-)
has only substance units: false
constant: false
is: HMDB01202
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_853d75bc_6dec_42d5_a1b9_227801211aeb
initial amount: NaN
boundary condition: true
is encoded by: hsa:3034
is: SBO:0000252
is: B4E0V8
type: Species
constant: false
name: HAL
has only substance units: false
initial concentration: NaN

metaM clpndcoa c
name: clupanodonyl CoA
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: C16166
is: http://identifiers.org/pubchem.compound/47205476
type: Species
is: HMDB06267
constant: false
has only substance units: false

metaM aprgstrn c
boundary condition: false
is: CHEBI:28453
has only substance units: false
is: HMDB03069
constant: false
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042
name: (20S)-20-hydroxypregn-4-en-3-one
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaM bilglcur e
type: Species
name: mono(glucosyluronic acid)bilirubin(2-)
is: CHEBI:57767
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM h x
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: C00080
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: SBO:0000247
has only substance units: false
name: proton
initial concentration: 1.0
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380

metaM CE5117 m
has only substance units: false
initial amount: NaN
is: CHEBI:12947
type: Species
is: SBO:0000247
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
boundary condition: false
constant: false
initial concentration: 1.0

metaM HC02205 e
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28099
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
constant: false
name: prostaglandin-b2

http://identifiers.org/biomodels.db/MODEL1310110011#_53fdd46b_cfff_47a2_899e_86df252564ef
type: Species
name: _2544_1_c
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:2544
initial concentration: NaN
initial amount: NaN

metaR AKGMALtm
reactant: MODEL1310110011#
name: alpha-ketoglutarate/malate transporter
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
reversible: true
fast: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
modifier: MODEL1310110011#
type: Reaction

metaM pcrn c
initial amount: NaN
is: HMDB00824
type: Species
name: propionyl-carnitine
is: http://identifiers.org/pubchem.compound/107738
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR ABTti
is described by: ECO:0000000
reversible: false
type: Reaction
name: L-arabinitol transport via passive diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
product: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_6e4871ab_87b7_4604_9656_4276f7959535
constant: false
initial amount: NaN
is encoded by: hsa:T83654
name: _T83654_1_c
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR 2MCITt
kinetic law: MODEL1310110011#
fast: false
reversible: true
reactant: MODEL1310110011#
is: SBO:0000185
type: Reaction
name: 2-methylcitrate transport via diffusion
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:426765 NOTES:MM
is described by: ECO:0000000

metaM acgam6p c
has only substance units: false
boundary condition: false
is: SBO:0000247
name: N-acetyl-D-glucosamine 6-phosphate(2-)
type: Species
is: CHEBI:57513
is: HMDB01062
initial amount: NaN
constant: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
initial concentration: 1.0

metaM thm c
initial concentration: 1.0
is: HMDB00235
type: Species
is: SBO:0000247
is: C00378
initial amount: NaN
name: Thiamin
boundary condition: false
is: CHEBI:0
notes: FORMULA: C12H17N4OS CHARGE: 1
has only substance units: false
constant: false

metaM o2 m
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: CHEBI:15379
is: C00007
has only substance units: false
is: HMDB01377
name: O2
constant: false

metaR PIt8
reversible: true
modifier: MODEL1310110011#
is described by: ECO:0000006
fast: false
reactant: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
kinetic law: MODEL1310110011#
name: phosphate transport in/out via Na+ symporter
type: Reaction
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM

metaR C204CRNt
name: arachidonic acid transport into the mitochondria
type: Reaction
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
fast: false
reversible: false
is: SBO:0000185
reactant: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000000

metaM aacoa m
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:57286
type: Species
name: acetoacetyl-CoA(4-)
has only substance units: false
is: HMDB01484
is: SBO:0000247
constant: false

metaR BETALDHxm
type: Reaction
reversible: false
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 2 AUTHORS: PMID:15321791 NOTES:MM
name: betaine-aldehyde dehydrogenase, mitochondrial
reactant: MODEL1310110011#
is described by: ECO:0000000
fast: false

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_5dae55f1_f736_458b_8efe_5a1e8589f2f8
name: SLC26A2
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1836
is: SBO:0000252
type: Species
has only substance units: false
is: P50443
initial amount: NaN

metaM for e
name: formate
has only substance units: false
constant: false
is: CHEBI:15740
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00142
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
type: Species

metaM bilglcur c
constant: false
name: mono(glucosyluronic acid)bilirubin(2-)
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:57767
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374

metaR PIt7
is: SBO:0000185
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
modifier: MODEL1310110011#
is described by: ECO:0000269
reactant: MODEL1310110011#
type: Reaction
fast: false
kinetic law: MODEL1310110011#
reversible: true
product: MODEL1310110011#
name: phosphate transport in/out via three Na+ symporter

metaM ksii core2 g
is: CHEBI:17140
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
name: keratan sulfate II (core 2-linked)
initial amount: NaN
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: SBO:0000247
type: Species
is: HMDB01644

http://identifiers.org/biomodels.db/MODEL1310110011#_4f2a0fbd_9728_457e_bbe9_ddffeb99f38d
name: FASN
is: SBO:0000252
initial amount: NaN
type: Species
is: P49327
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2194

metaR TTDCPT2
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
modifier: MODEL1310110011#
name: carnitine transferase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_1588ddc3_cb9d_4ab2_a300_4a61b89289ab
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
name: EARS2
is encoded by: hsa:124454
is: Q5JPH6
type: Species
initial concentration: NaN
initial amount: NaN

metaR AG13T11g
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110011#
fast: false
modifier: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
reversible: false
product: MODEL1310110011#
type: Reaction

metaR r2397
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110011#
is: SBO:0000185
product: MODEL1310110011#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110011#_cba0742c_d136_4b87_84fd_462162ebdae8
is: Q8NCI4
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:54872
boundary condition: true
type: Species
has only substance units: false
constant: false
name: PIGG
initial amount: NaN

metaR RE2677E
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
kinetic law: MODEL1310110011#
fast: false
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110011#
name: RE2677
reactant: MODEL1310110011#

metaM glyphe e
is: SBO:0000247
name: Glycylphenylalanine
is: http://identifiers.org/pubchem.compound/97415
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C11H14N2O3 CHARGE: 0
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_2f4c5d4a_dbc8_4c10_906c_10203750190b
is: SBO:0000252
constant: false
boundary condition: true
is: B2R6S5
initial amount: NaN
name: CMPK1
is encoded by: hsa:51727
initial concentration: NaN
type: Species
has only substance units: false

metaM datp m
boundary condition: false
has only substance units: false
name: dATP
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
initial concentration: 1.0
is: HMDB01532
is: C00131
is: CHEBI:61404
initial amount: NaN
is: SBO:0000247
constant: false
type: Species

metaM 5eipencoa m
is: SBO:0000247
name: 5,8,11,14,17-eicosapentenoylcoa
type: Species
is: HMDB06294
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_a72e9c43_60f3_47a5_847d_c2e87431bfd4
initial amount: NaN
constant: false
is encoded by: hsa:9926
name: LPGAT1
has only substance units: false
type: Species
is: SBO:0000252
is: Q92604
boundary condition: true
initial concentration: NaN

metaM ksii core2 e
is: CHEBI:17268
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
constant: false
initial concentration: 1.0
type: Species
is: HMDB00211
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
name: keratan sulfate II (core 2-linked)

metaR FACOAL170
reversible: true
is: SBO:0000176
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110011#
is described by: ECO:0000000
reactant: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
modifier: MODEL1310110011#

metaR r0999
fast: false
product: MODEL1310110011#
reactant: MODEL1310110011#
is: SBO:0000185
name: Facilitated diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
kinetic law: MODEL1310110011#
reversible: true
type: Reaction

metaM 3hddcoa m
initial concentration: 1.0
is: C05280
has only substance units: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
is: SBO:0000247
boundary condition: false
name: (S)-3-Hydroxydodecanoyl-CoA
type: Species
initial amount: NaN
is: HMDB03952
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_2676fe60_4740_4b94_a5b3_a4cf5332b0b2
boundary condition: true
has only substance units: false
type: Species
constant: false
name: HEPH
is: E9PHN8
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:9843
initial amount: NaN

metaR r1007
reversible: true
name: Facilitated diffusion
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
product: MODEL1310110011#
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_f1417b0a_2874_4d3a_9ef4_82d409f21501
is encoded by: hsa:AI971036
constant: false
name: _AI971036_1_m
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_f61a641d_d393_47b9_9d70_d71dea72c2cd
initial amount: NaN
initial concentration: NaN
constant: false
is: D3DX95
has only substance units: false
name: CHAT
is encoded by: hsa:1103
type: Species
is: SBO:0000252
boundary condition: true

metaR DESAT18 4
fast: false
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.19.1
is: SBO:0000176
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
reversible: false
reactant: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#

metaM hdcecrn m
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
name: Hexadecenoyl carnitine
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00222

http://identifiers.org/biomodels.db/MODEL1310110011#_428c8ffb_2060_4e91_9f95_bf5b47d0a8ab
boundary condition: true
is: SBO:0000252
has only substance units: false
is: B3KVI7
initial amount: NaN
constant: false
is encoded by: hsa:3712
type: Species
initial concentration: NaN
name: IVD

http://identifiers.org/biomodels.db/MODEL1310110011#_078f82fd_8676_4d0a_8509_1ab4a32fd972
is: SBO:0000252
name: SLC27A2
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: O14975
is encoded by: hsa:11001

metaM dcsptn1coa c
is: HMDB06513
is: http://identifiers.org/pubchem.compound/47205483
has only substance units: false
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: SBO:0000247
is: C16173

http://identifiers.org/biomodels.db/MODEL1310110011#_631e3abd_3df3_4235_9dcf_d5702a384065
is: Q9Y217
initial amount: NaN
constant: false
initial concentration: NaN
name: MTMR6
is encoded by: hsa:9107
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR GGLUCT
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110011#
reversible: false
name: gamma-glutamylcyclotransferase
is described by: ECO:0000269
reactant: MODEL1310110011#
modifier: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/2.3.2.4
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB

metaR r1560
kinetic law: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110011#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaR 2AMADPTm
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
is: SBO:0000185
kinetic law: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
is described by: ECO:0000269
reversible: true
fast: false
modifier: MODEL1310110011#

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_6f79c353_7870_4bbf_8579_14d2fe646364
is: SBO:0000252
is: Q6LEN6
has only substance units: false
is encoded by: hsa:1103
constant: false
name: CHAT
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN

metaR r1621
product: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_59ae76a9_0932_4a21_8ae2_b75867e4deec
boundary condition: true
has only substance units: false
is: O00462
initial concentration: NaN
initial amount: NaN
name: MANBA
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:4126

http://identifiers.org/biomodels.db/MODEL1310110011#_bb97fdcf_74f6_47c7_9bb1_4f044c59da84
constant: false
initial concentration: NaN
is encoded by: hsa:6342
is: SBO:0000252
is: C9JC79
initial amount: NaN
has only substance units: false
name: SCP2
type: Species
boundary condition: true

metaR FAOXC161802m
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000176
reactant: MODEL1310110011#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation fatty acid
modifier: MODEL1310110011#
type: Reaction

metaR TYRt
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
type: Reaction
reactant: MODEL1310110011#
is described by: ECO:0000269
modifier: MODEL1310110011#
product: MODEL1310110011#
kinetic law: MODEL1310110011#
fast: false
name: L-tyrosine transport
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110011#_c64d87e6_a17f_4a90_920d_5b060f0adf02
is encoded by: hsa:4056
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: LTC4S
constant: false
initial amount: NaN
has only substance units: false
is: Q16873
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_1fbd2e9c_3eae_4310_8988_3e07847422f9
initial concentration: NaN
is encoded by: hsa:5149
constant: false
initial amount: NaN
type: Species
name: PDE6H
is: SBO:0000252
is: Q13956
boundary condition: true
has only substance units: false

metaM CE2433 m
boundary condition: false
initial amount: NaN
type: Species
is: C01936
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
constant: false
is: SBO:0000247
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
initial concentration: 1.0

metaR SPHK21c
reversible: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.7.1.91
modifier: MODEL1310110011#
fast: false
product: MODEL1310110011#
name: sphingosine kinase 2
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_6b190d52_c283_4e14_a77e_d329c29e4f12
initial amount: NaN
is encoded by: hsa:79053
initial concentration: NaN
is: A6NDW6
constant: false
boundary condition: true
name: ALG8
is: SBO:0000252
type: Species
has only substance units: false

metaR FAOXC8C6m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)m
type: Reaction

metaR TRIODTHYt2
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
name: T3 transport via facilitated diffusion
reactant: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
reversible: true
is: SBO:0000185
type: Reaction

metaR r1620
fast: false
is: SBO:0000185
modifier: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
product: MODEL1310110011#
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_95787dbe_7531_4d5b_a09e_4570f9524539
has only substance units: false
name: LHPP
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:64077
boundary condition: true
type: Species
constant: false
is: Q9H008

http://identifiers.org/biomodels.db/MODEL1310110011#_fec895b4_41c9_4f11_9f3b_0ef3654253f9
has only substance units: false
is: Q5T4Y1
is encoded by: hsa:6487
initial amount: NaN
name: ST3GAL3
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_2fa07d84_2e46_405c_9979_fcf559c4cbaf
initial amount: NaN
has only substance units: false
name: _AA629629_1_m
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:AA629629
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110011#_7e9a179f_a13b_4322_9cb7_9f4a543e6f7d
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110011#_16849f36_ddcb_4233_89b8_c028a1cebaf0
name: SLC35D2
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:11046
is: Q76EJ3

http://identifiers.org/biomodels.db/MODEL1310110011#_3fd3dbf1_5305_44c0_9a94_2d8fb968c000
is: SBO:0000252
is encoded by: hsa:LOC374569
has only substance units: false
type: Species
name: _LOC374569_1_e
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

metaR r1562
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110011#
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
product: MODEL1310110011#
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_432f7f3b_1c76_4b9b_a5c5_57b2b1c4fe51
is: P00326
is encoded by: hsa:126
constant: false
name: ADH1C
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR r1623
type: Reaction
reactant: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110011#

metaR UMPKn
is described by: ECO:0000269
product: MODEL1310110011#
fast: false
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase, nuclear
kinetic law: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
reversible: true

metaR BILDGLCURt
product: MODEL1310110011#
modifier: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110011#
is described by: ECO:0000269
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_bdd35030_7210_47b8_b117_bcf48237a485
is encoded by: hsa:2180
initial amount: NaN
constant: false
is: SBO:0000252
is: P33121
initial concentration: NaN
type: Species
name: ACSL1
has only substance units: false
boundary condition: true

metaR G14T16g
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
type: Reaction
modifier: MODEL1310110011#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110011#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110011#_cc91e9e2_8276_4afc_991f_fc4b5c16f079
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:8818
has only substance units: false
name: DPM2

http://identifiers.org/biomodels.db/MODEL1310110011#_416582eb_25a7_481c_bdfa_be34dbe04e61
initial amount: NaN
boundary condition: true
name: ADCY8
type: Species
initial concentration: NaN
is encoded by: hsa:114
has only substance units: false
is: SBO:0000252
constant: false
is: Q4F7X0

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_0582af80_306d_4f1b_9675_cf80ebd7a7f5
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
constant: false
name: PPAP2B
initial concentration: NaN
is encoded by: hsa:8613
is: O14495
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_91ca65e5_63f2_429e_9dd6_d89795341244
constant: false
type: Species
is: SBO:0000252
name: CPT1B
is encoded by: hsa:1375
is: B7Z5T8
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR r1561
type: Reaction
reactant: MODEL1310110011#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110011#
kinetic law: MODEL1310110011#
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaR r1622
is: SBO:0000185
fast: false
type: Reaction
modifier: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110011#

metaM 4abutn e
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: SBO:0000247
name: 4-ammoniobutanal
is: CHEBI:58264
type: Species
has only substance units: false
is: HMDB01080
initial concentration: 1.0
constant: false

metaR C142ACBP
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradeca dienoyl coa from mitochondria into cytosol
type: Reaction

metaR RTOTAL2t
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
fast: false
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000000
reactant: MODEL1310110011#
name: RTOTAL2 transport
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_c22af3f0_5bca_4b7d_b46e_bc59e76255a3
initial concentration: NaN
is: P21912
initial amount: NaN
constant: false
boundary condition: true
name: SDHB
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6390
type: Species

metaM HC01609 e
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
type: Species
constant: false
name: UroporphyrinogenI
boundary condition: false
is: CHEBI:28766
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM dnad c
is: C00857
is: SBO:0000247
has only substance units: false
name: Deamino-NAD+
is: CHEBI:18304
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB01179
initial amount: NaN
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
constant: false

metaM 3hodcoa c
type: Species
initial concentration: 1.0
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
name: (S)-3-Hydroxyoctadecanoyl-CoA
boundary condition: false
is: HMDB13336

http://identifiers.org/biomodels.db/MODEL1310110011#_893d2e5d_bd0c_46ca_9e9e_d75569a47397
is: SBO:0000252
boundary condition: true
is encoded by: hsa:220
is: P47895
name: ALDH1A3
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_146a462c_6a5d_43d8_8c48_d227830c2a66
is encoded by: hsa:80308
name: FLAD1
has only substance units: false
initial amount: NaN
is: Q8NFF5
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_1c9a31aa_0368_4dd3_bb16_9f4a77b75a77
name: PDE4C
boundary condition: true
is: Q7KYS4
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:5143
has only substance units: false

metaR ALAR
name: alanine racemase
is described by: ECO:0000212
modifier: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
is: SBO:0000176
reversible: true
fast: false

metaR ALADGLYexR
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
name: D-alanine/glycine reversible exchange
is described by: ECO:0000304
reversible: true
product: MODEL1310110011#
modifier: MODEL1310110011#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110011#_962096a5_e15e_4684_b260_60a58f640671
is: SBO:0000252
constant: false
is encoded by: hsa:AA278423
name: _AA278423_1_m
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR DCSPTN1COAtx
fast: false
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110011#
name: fatty acid intracellular transport
kinetic law: MODEL1310110011#

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_36ed8816_b733_4255_b175_5fcfeba47c76
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:84532
name: ACSS1
boundary condition: true
initial concentration: NaN
is: Q9NUB1

metaR DM Lcystin
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for L-cystine
type: Reaction

metaR DHCRD2
reactant: MODEL1310110011#
is: SBO:0000176
kinetic law: MODEL1310110011#
type: Reaction
reversible: false
modifier: MODEL1310110011#
name: dihydroceramide desaturase
is described by: ECO:0000269
fast: false
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ

metaR r1625
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110011#
modifier: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110011#_52208ffd_8e21_42b5_878f_db0c130b854f
constant: false
name: PRDX2
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:7001

http://identifiers.org/biomodels.db/MODEL1310110011#_92127ada_0cd9_4b5c_bd06_a296c08f7446
has only substance units: false
name: SLC16A10
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:117247
constant: false
initial amount: NaN
is: Q8TF71

metaM 3mob m
type: Species
name: 3-methyl-2-oxobutanoate
constant: false
initial amount: NaN
is: HMDB00019
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: CHEBI:11851
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_f080c59f_28ed_4e70_93af_0471eb0b9e72
name: AUH
is: Q13825
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:549
initial concentration: NaN
has only substance units: false

metaR H2Otp
reactant: MODEL1310110011#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110011#
fast: false
is described by: ECO:0000000
product: MODEL1310110011#
name: H2O transport, peroxisomal
reversible: true

metaM ksi pre8 g
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
name: keratan sulfate I biosynthesis, precursor 8
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28067
has only substance units: false
type: Species

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaR r1624
reactant: MODEL1310110011#
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110011#

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

metaR PEt
kinetic law: MODEL1310110011#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
is: SBO:0000185
product: MODEL1310110011#
reversible: true
name: phosphatidylethanolamine transport

http://identifiers.org/biomodels.db/MODEL1310110011#_234d308f_66c2_4fb4_92c1_47368b533317
is encoded by: hsa:6675
initial concentration: NaN
constant: false
is: Q16222
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
name: UAP1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_f1648715_6636_4a89_a518_913d8f12fbe1
constant: false
is: SBO:0000252
is encoded by: hsa:219
is: P30837
name: ALDH1B1
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR CHATn
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110011#
name: Choline O-acetyltransferase
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/2.3.1.6
reactant: MODEL1310110011#

metaR PROSTGF2t
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
type: Reaction
reversible: true
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110011#
name: prostaglandin uniport
is: SBO:0000185
reactant: MODEL1310110011#
product: MODEL1310110011#
modifier: MODEL1310110011#

metaM nrvnccoa x
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
initial amount: NaN
is: SBO:0000247
is: C16532
name: nervonyl coenzyme A
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
constant: false

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaM dhcrm hs c
is: CHEBI:31488
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: dihydroceramide

metaR HPDCACRNt
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
fast: false
product: MODEL1310110011#
is described by: ECO:0000269
reversible: false
name: heptadecanoate transport into the mitochondria
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
is: SBO:0000185

metaM nad x
initial concentration: 1.0
is: C00003
type: Species
name: Nicotinamide adenine dinucleotide
is: CHEBI:57540
constant: false
is: HMDB00902
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3305
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_034161b4_c57f_4b84_8c3d_163d4d88227f
type: Species
is: P05187
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:250
name: ALPP
has only substance units: false

metaR RE3001M
name: RE3001
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.34
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
type: Reaction
reversible: true
modifier: MODEL1310110011#
fast: false

metaR ETOHt
reversible: true
fast: false
product: MODEL1310110011#
is: SBO:0000185
type: Reaction
name: ethanol reversible transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#

metaM HC01602 c
is: C00234
name: 10-Formyltetrahydrofolate
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
boundary condition: false
is: CHEBI:57454
is: SBO:0000247
initial amount: NaN

metaR H3ETer
reversible: false
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
product: MODEL1310110011#
name: H3 phosphoethanolaminyl transferase, endoplasmic reticulum
is described by: ECO:0000304
kinetic law: MODEL1310110011#
fast: false
is: SBO:0000176
modifier: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#

metaR r1627
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110011#
reversible: true
is described by: ECO:0000000
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110011#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110011#_cab52ac7_daef_484e_896f_80d28645ad45
initial amount: NaN
type: Species
constant: false
is: P53597
has only substance units: false
is: SBO:0000252
boundary condition: true
name: SUCLG1
is encoded by: hsa:8802
initial concentration: NaN

metaR EX 3hexdcrn
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecanoyl carnitine
type: Reaction

metaM nrpphr e
name: Norepinephrine
has only substance units: false
is: CHEBI:33569
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
initial amount: NaN
is: HMDB00216
type: Species

http://identifiers.org/biomodels.db/MODEL1310110011#_37c2917d_daea_413e_971b_5e678852be27
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4952
name: OCRL
is: SBO:0000252
type: Species
boundary condition: true

metaR TETPENT6COAtx
fast: false
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110011#
reversible: true
is described by: ECO:0000000
name: fatty acid intracellular transport
type: Reaction

metaR SERDGLNexR
modifier: MODEL1310110011#
is: SBO:0000185
is described by: ECO:0000304
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: D-Serine/Glutamine reversible exchange
reversible: true
type: Reaction
fast: false
product: MODEL1310110011#

metaR H2Otn
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: H2O transport, nuclear
type: Reaction
is: SBO:0000185
reactant: MODEL1310110011#
product: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000000

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaM cala c
name: N-carbamoyl-beta-alaninate
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
is: SBO:0000247
has only substance units: false
is: CHEBI:11892
constant: false
initial concentration: 1.0
is: HMDB00026

http://identifiers.org/biomodels.db/MODEL1310110011#_7d7e7c16_7566_4fa9_bf35_cf49694edc6f
is: Q9H0P0
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:51251
constant: false
name: NT5C3
initial concentration: NaN
type: Species

metaR r1626
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110011#
is: SBO:0000185
modifier: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110011#
product: MODEL1310110011#

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaR r1568
is: SBO:0000185
reactant: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110011#
is described by: ECO:0000000
product: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR ADPACTD
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport into cytosol (diffusion)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_20483e3a_103c_4220_a665_90d3661bbe31
initial amount: NaN
is encoded by: hsa:80025
boundary condition: true
is: SBO:0000252
is: Q9BZ23
has only substance units: false
initial concentration: NaN
name: PANK2
constant: false
type: Species

metaR r1629
is: SBO:0000185
fast: false
kinetic law: MODEL1310110011#
is described by: ECO:0000000
reactant: MODEL1310110011#
product: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_644661fa_9e87_4eca_98ca_3bdebca93fe9
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:6390
is encoded by: hsa:6389
type: Species
has part: O14521
is: SBO:0000297
is encoded by: hsa:6392
is encoded by: hsa:6391
has part: P31040
has part: Q99643
has part: P21912
name: SDHA:SDHB:SDHC:SDHD
constant: false

metaR LEUGLYPEPT1tc
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_cc9efbaa_1642_44f9_ac53_32a15c02692f
type: Species
is encoded by: hsa:1215
initial concentration: NaN
name: CMA1
is: SBO:0000252
has only substance units: false
constant: false
is: Q4FEB3
boundary condition: true
initial amount: NaN

metaM fmn c
name: FMN
is: C00061
is: HMDB01520
constant: false
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
is: CHEBI:58210
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_1b0bf067_d2c4_4809_b5dc_7a70e3f38dd4
name: _22305_2_c
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:22305
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM o2s e
is: CHEBI:18421
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB02168
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247
name: superoxide
type: Species

metaM xylt e
has only substance units: false
is: CHEBI:17151
is: HMDB02917
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
name: xylitol

metaM HC01401 m
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
is: CHEBI:27668
name: (S)-3-Hydroxydodecanoyl-CoA
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110011#_28c633f3_37ab_4491_aa72_e2c4902371ef
name: SLC16A2
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:6567
is: P36021

metaR r1567
reactant: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110011#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaR NAt3 1
fast: false
name: sodium proton antiporter (H:NA is 1:1)
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
type: Reaction
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
is: SBO:0000185

metaM tetpent3 e
name: tetracosapentaenoic acid, n-3
is: HMDB06323
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: false

metaR LEUKTRA4tr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110011#
is: SBO:0000185
product: MODEL1310110011#
name: leukotriene intracellular transport
reactant: MODEL1310110011#
type: Reaction

metaR r1628
reversible: true
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110011#

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR OCD11CRNCPT2
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaM dmpp x
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: prenyl diphosphate(3-)
is: CHEBI:57623
boundary condition: false
type: Species
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
is: HMDB01120

metaR FAOXC18280m
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:2, transe -> c8:0 - 5 rounds of beta ox, lose 2 degrees of unsat - only 3 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110011#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
product: MODEL1310110011#
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
name: Beta oxidation of fatty acid

metaM glyc3p x
name: Glycerol 3-phosphate
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: C00093
is: CHEBI:57597
type: Species
is: HMDB00126
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM nrpphr c
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
name: Norepinephrine
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00216
initial amount: NaN
has only substance units: false
is: CHEBI:33569
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_051cb82d_2d36_4fbf_9ddc_9c89d19c71b6
boundary condition: true
name: _T83654_1_e
initial amount: NaN
is encoded by: hsa:T83654
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR INSTt2r
type: Reaction
is described by: ECO:0000269
name: inositol transport in via proton symport
reactant: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
modifier: MODEL1310110011#
reversible: true
is: SBO:0000185
product: MODEL1310110011#
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_9b3d5b09_3411_4d5f_aed9_67c95d78bd56
has only substance units: false
is encoded by: hsa:2687
boundary condition: true
initial concentration: NaN
constant: false
name: GGT5
is: P36269
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_dab7a08d_70a5_481e_a82b_7459c809afbb
is encoded by: hsa:158
constant: false
initial concentration: NaN
name: ADSL
type: Species
has only substance units: false
initial amount: NaN
is: P30566
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_f0257863_f0b8_41cc_b626_e84da3b971a9
boundary condition: true
name: GPX1
is: P07203
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:2876
has only substance units: false
type: Species

metaR DOLPMT3 Ler
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.260
type: Reaction
reversible: false
reactant: MODEL1310110011#
is described by: ECO:0000000
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
product: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_c5f43b27_0386_4e67_9718_7c4849f1f4f2
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: NDUFS8
has only substance units: false
constant: false
is encoded by: hsa:4728
is: O00217
initial concentration: NaN
type: Species

metaR r2037
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
modifier: MODEL1310110011#
reversible: false
reactant: MODEL1310110011#
product: MODEL1310110011#
type: Reaction

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaM o2s c
name: superoxide
is: CHEBI:18421
is: HMDB02168
initial concentration: 1.0
has only substance units: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
constant: false

metaR FAOXC102C103m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaM xylt c
is: CHEBI:17151
is: HMDB02917
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
name: xylitol
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR r1569
fast: false
reactant: MODEL1310110011#
product: MODEL1310110011#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_e0288b05_c31a_4a6d_92ce_8fdb4359a582
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:10637
is: O75610
name: LEFTY1
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR r2369
reactant: MODEL1310110011#
product: MODEL1310110011#
name: Organic anion transporter 5 Utilized transport
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_6ceb48d2_89ac_452f_8809_258b1774b1fe
initial amount: NaN
is encoded by: hsa:55312
is: B2RDZ2
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
name: RFK
is: SBO:0000252
constant: false

metaM tetpent3 c
is: HMDB06323
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
name: tetracosapentaenoic acid, n-3
type: Species

metaM maltttr e
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
has only substance units: false
is: HMDB01296
boundary condition: false
constant: false
type: Species
is: SBO:0000247
name: Maltotetraose
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5141
is: C02052
initial amount: NaN

metaR r2036
kinetic law: MODEL1310110011#
type: Reaction
is: SBO:0000185
fast: false
reversible: false
reactant: MODEL1310110011#
product: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110011#

metaM so3 m
is: HMDB00240
initial concentration: 1.0
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: hydrogensulfite
has only substance units: false
constant: false
is: CHEBI:17137
type: Species

metaR r0033
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
reactant: MODEL1310110011#
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
kinetic law: MODEL1310110011#
is described by: ECO:0000000
product: MODEL1310110011#
reversible: false
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110011#

metaR DHDPBMTm
product: MODEL1310110011#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.1.114
reversible: false
name: dihydroxydecaprenylbenzoate methyltransferase
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: 2.1.1.114 Confidence Level: 4 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.1.1.114 IT
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110011#

metaM 4abutn m
initial amount: NaN
is: HMDB01080
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
type: Species
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:58264
initial concentration: 1.0
name: 4-ammoniobutanal

metaR CYTK5n
is: SBO:0000176
modifier: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
type: Reaction
product: MODEL1310110011#
reversible: true
kinetic law: MODEL1310110011#
fast: false
name: cytidylate kinase (CMP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269

metaM tdchola c
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: CHEBI:9407
initial concentration: 1.0
type: Species
constant: false
name: taurochenodeoxycholate
is: SBO:0000247
is: HMDB00951
boundary condition: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_3c302779_a890_4451_abb3_7f9f0420129e
name: _U37519_1_c
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:U37519

metaR r2368
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110011#
reversible: true
is: SBO:0000185
reactant: MODEL1310110011#
product: MODEL1310110011#

metaM adrncoa x
is: C16170
is: http://identifiers.org/pubchem.compound/47205480
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
boundary condition: false
name: adrenyl coenzyme A
initial amount: NaN

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaM gsn e
constant: false
has only substance units: false
name: Guanosine
initial concentration: 1.0
is: HMDB00133
type: Species
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: CHEBI:16750
is: C00387
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR r1564
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110011#
product: MODEL1310110011#
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110011#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_8fa5e96f_fcec_4f7b_b30d_5f914edc4728
name: HPD
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: B3KQ63
is encoded by: hsa:3242
is: SBO:0000252
boundary condition: true
constant: false

metaM occoa c
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
has only substance units: false
type: Species
boundary condition: false
is: HMDB01070
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: C01944
is: CHEBI:57386
name: Octanoyl-CoA (n-C8:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110011#_3434a3aa_eae5_4aaa_afad_04bac39ee5e2
is: P32929
is encoded by: hsa:1491
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
name: CTH
has only substance units: false
type: Species
initial amount: NaN

metaR 5HOXINDACTO2OX
is version of: http://identifiers.org/ec-code/1.2.3.1
product: MODEL1310110011#
reversible: false
modifier: MODEL1310110011#
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.3.1 Confidence Level: 2 AUTHORS: PMID:11306106 NOTES:SAB questionable--balanced, but h2o2 production is based on an obscure comment in entrez
is described by: ECO:0000304
name: 5-Hydroxyindoleacetaldehyde:oxygen oxidoreductase
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_cf7b792c_5cc9_4ee4_bc0a_d36857b7ca7c
is: SBO:0000252
name: ACSL4
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:2182
has only substance units: false
is: Q5JWV8
initial amount: NaN

metaM CE4794 m
has only substance units: false
is: CHEBI:12947
name: cis-6-dodecenoyl-CoA
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
type: Species
initial amount: NaN

metaR r2367
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110011#
is described by: ECO:0000000
product: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
name: Organic anion transporter 5 Utilized transport

metaM ksi pre22 g
is: HMDB00175
constant: false
name: keratan sulfate I biosynthesis, precursor 22
is: SBO:0000247
boundary condition: false
is: CHEBI:58053
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
initial amount: NaN
has only substance units: false
type: Species
is: C00130
initial concentration: 1.0

metaM retinol c
is: SBO:0000247
name: retinol
constant: false
is: HMDB00305
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
type: Species
is: CHEBI:50211
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM ksi pre31 g
initial concentration: 1.0
type: Species
is: SBO:0000247
is: C00130
constant: false
is: HMDB00175
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 31
initial amount: NaN
is: CHEBI:58053
boundary condition: false
notes: FORMULA: C227H363N16O189S9X CHARGE: -10

metaR r1563
reactant: MODEL1310110011#
is described by: ECO:0000000
product: MODEL1310110011#
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaR FAOXC183C163m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)m
type: Reaction

metaR ACHtn
kinetic law: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
name: Acetylcholin transport, nuclear trhough pores
reactant: MODEL1310110011#
is: SBO:0000185
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it

metaR r2030
fast: false
kinetic law: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110011#
type: Reaction
modifier: MODEL1310110011#
reactant: MODEL1310110011#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaR SBCOAACOTx
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of suberyl coa for release into cytosol
type: Reaction

metaR PROSTGE1t
product: MODEL1310110011#
reversible: true
modifier: MODEL1310110011#
type: Reaction
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
fast: false
kinetic law: MODEL1310110011#
is described by: ECO:0000269
is: SBO:0000185
name: prostaglandin transport via bicarbonate countertransport
reactant: MODEL1310110011#

metaM dhcholestancoa x
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
initial amount: NaN
is: HMDB02159
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15494
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA

metaM tdchola e
boundary condition: false
has only substance units: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
constant: false
is: CHEBI:9407
is: SBO:0000247
type: Species
initial concentration: 1.0
name: taurochenodeoxycholate
is: HMDB00951
initial amount: NaN

metaM f6p c
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00124
boundary condition: false
is: http://identifiers.org/pubchem.compound/3385
initial amount: NaN
is: SBO:0000247
name: D-Fructose 6-phosphate
constant: false
is: C00085
is: CHEBI:57579

metaR CMPSASn
modifier: MODEL1310110011#
name: CMP sialic acid synthase, nuclear
is described by: ECO:0000304
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.43
reversible: false
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
kinetic law: MODEL1310110011#
product: MODEL1310110011#
type: Reaction

metaR ADK3m
kinetic law: MODEL1310110011#
product: MODEL1310110011#
type: Reaction
name: adentylate kinase (GTP)
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
modifier: MODEL1310110011#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.10
reversible: true
fast: false
reactant: MODEL1310110011#

metaR r1566
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110011#
type: Reaction
reactant: MODEL1310110011#
is described by: ECO:0000000
product: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110011#_11418469_f5a7_4487_af14_3fbd716d0fbf
type: Species
initial amount: NaN
name: FASN
constant: false
initial concentration: NaN
is: SBO:0000252
is: P49327
has only substance units: false
boundary condition: true
is encoded by: hsa:2194

metaM gsn c
name: Guanosine
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
type: Species
is: HMDB00133
is: CHEBI:16750
is: C00387
has only substance units: false
boundary condition: false

metaR CYSASNNaEx
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
reversible: false
modifier: MODEL1310110011#
product: MODEL1310110011#
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)

metaM fmn e
is: HMDB01520
constant: false
is: C00061
name: FMN
type: Species
is: CHEBI:58210
has only substance units: false
notes: FORMULA: C17H19N4O9P CHARGE: -2
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR r2366
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
product: MODEL1310110011#
reactant: MODEL1310110011#
name: Organic anion transporter 5 Utilized transport
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110011#

metaM ascb L e
is: HMDB00044
initial amount: NaN
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: CHEBI:38290
name: L-ascorbate
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0

metaM acmana c
is: CHEBI:17122
boundary condition: false
name: N-acetyl-D-mannosamine
is: HMDB01129
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_7c5c397e_21cc_43ee_b9fb_039c209ebfc3
name: SLC26A6
initial amount: NaN
is: Q9Y3Y1
is encoded by: hsa:65010
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110011#_61838b0f_a0db_42a0_bd05_c067b029b78f
boundary condition: true
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial concentration: NaN
name: _AI656480_1_m
is encoded by: hsa:AI656480
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_c62c8f9f_a0c8_40b5_bbb4_37549e8cc187
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:5152
constant: false
name: PDE9A
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110011#_97e8d303_321c_4591_a83d_cfb883bc9571
initial amount: NaN
type: Species
name: SLC8A3
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:6547
constant: false

metaM cdp n
boundary condition: false
name: CDP(3-)
initial concentration: 1.0
is: CHEBI:58069
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
type: Species
is: HMDB01546
has only substance units: false
constant: false

metaR BILGLCURtr
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
name: glucuronidated compound transport
fast: false
is described by: ECO:0000000
reactant: MODEL1310110011#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110011#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110011#_1356502d_cee3_4e4b_929a_7dbd3a94acad
constant: false
is encoded by: hsa:10637
is: SBO:0000252
initial concentration: NaN
name: LEFTY1
type: Species
has only substance units: false
boundary condition: true
is: O75610
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_fe28e565_0c40_4e83_b86f_19a99e2b913b
name: ALG1
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: Q9BT22
is encoded by: hsa:56052
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110011#_d9041202_3970_46a6_9bf9_3de8fb805529
constant: false
is encoded by: hsa:AI653169
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: _AI653169_1_c
has only substance units: false
type: Species

metaR r1565
kinetic law: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110011#
product: MODEL1310110011#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r1779
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: false
name: Y+LAT2 Utilized transport
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000000
modifier: MODEL1310110011#
fast: false
kinetic law: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_e928ed22_927d_44b3_9fdc_93e20b9681cf
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:6482
initial amount: NaN
name: ST3GAL1

metaR r2365
reversible: true
kinetic law: MODEL1310110011#
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110011#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reactant: MODEL1310110011#

metaM CE4790 m
initial concentration: 1.0
initial amount: NaN
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
has only substance units: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:12947
constant: false

http://identifiers.org/biomodels.db/MODEL1310110011#_7711e57f_e7e9_425a_8f62_da949df951c4
is encoded by: hsa:622
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species
name: BDH1

metaM ksii core2 pre3 g
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 3
has only substance units: false
is: SBO:0000247
notes: FORMULA: C47H76N4O33X CHARGE: -1
is: CHEBI:58053
type: Species
is: HMDB00175
is: C00130

metaM dag hs r
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: diglyceride
boundary condition: false
is: CHEBI:18035
initial concentration: 1.0
type: Species
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055

metaM 3decdicoa m
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
name: 3,7-decadienoylcoa

metaR r2363
is: SBO:0000185
product: MODEL1310110011#
reversible: true
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110011#
type: Reaction
kinetic law: MODEL1310110011#

metaR KHte
product: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110011#
is: SBO:0000185
name: KHte
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110011#

http://identifiers.org/biomodels.db/MODEL1310110011#_51331783_db59_4123_8de2_68f005789cc1
is: SBO:0000252
name: AKR1A1
boundary condition: true
is encoded by: hsa:10327
type: Species
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN

metaR DM anth
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR ADEt
reactant: MODEL1310110011#
reversible: true
type: Reaction
fast: false
name: adenine reversible transport, cytosol
is: SBO:0000185
modifier: MODEL1310110011#
product: MODEL1310110011#
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
is described by: ECO:0000269

metaR RE3421R
product: MODEL1310110011#
name: RE3421
reactant: MODEL1310110011#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110011#

metaM adrncoa c
name: adrenyl coenzyme A
type: Species
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205480
is: C16170
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_f5238040_7236_4777_9892_815e0c057f1d
is: SBO:0000252
initial amount: NaN
name: SLC13A4
is: Q9UKG4
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:26266
boundary condition: true

metaM dgsn c
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
has only substance units: false
is: HMDB00085
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17172
type: Species
initial amount: NaN
name: Deoxyguanosine
is: C00330

metaR r2364
product: MODEL1310110011#
name: Organic anion transporter 5 Utilized transport
reversible: true
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110011#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_033f85d6_efcb_4980_b6eb_af7b348ad2d8
is: O43511
is encoded by: hsa:5172
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: SLC26A4

http://identifiers.org/biomodels.db/MODEL1310110011#_62b8fe8b_65ec_4f20_8bcb_e964feb8ba7d
constant: false
is: Q3I5F7
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
name: ACOT6
is encoded by: hsa:641372
is: SBO:0000252

metaM cit m
boundary condition: false
is: CHEBI:16947
initial concentration: 1.0
is: C00158
is: HMDB00094
initial amount: NaN
has only substance units: false
name: Citrate
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
constant: false
is: SBO:0000247
type: Species

metaM prostgd2 r
name: prostaglandin D2(1-)
constant: false
is: CHEBI:57406
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: HMDB01403
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species

metaR EX ascb L LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Ascorbate exchange
type: Reaction

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_65631ca0_7c07_4f10_b660_10bc626ac6ca
is encoded by: hsa:37
has only substance units: false
name: ACADVL
is: SBO:0000252
boundary condition: true
is: P49748
constant: false
initial amount: NaN
initial concentration: NaN
type: Species

metaR PAFt
reactant: MODEL1310110011#
fast: false
product: MODEL1310110011#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110011#
name: 1-alkyl 2-acteylglycerol 3-phosphocholine transport
is: SBO:0000185

metaM tetpent3coa c
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1
has only substance units: false
is: SBO:0000247
constant: false
is: C16167
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: tetracosapentaenoyl coenzyme A, n-3
type: Species

metaR RE3524R
name: RE3524
reactant: MODEL1310110011#
reversible: true
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:

metaR NDPK2n
product: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110011#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is described by: ECO:0000269
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
modifier: MODEL1310110011#
reactant: MODEL1310110011#
type: Reaction
reversible: true

metaR r2361
product: MODEL1310110011#
is: SBO:0000185
reversible: true
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
kinetic law: MODEL1310110011#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110011#

metaR C4CRNe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of butyryl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110011#_37b9f29a_cdc0_4362_8caf_ace5ca3cbbba
is: SBO:0000252
boundary condition: true
is: Q8TCD5
name: NT5C
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:30833
initial amount: NaN

metaR DESAT24 1
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
fast: false
product: MODEL1310110011#
reversible: false
type: Reaction
reactant: MODEL1310110011#
kinetic law: MODEL1310110011#
name: fatty acyl-CoA desaturase (n-C24:5CoA -> n-C24:6CoA)
modifier: MODEL1310110011#
is: SBO:0000176
is described by: ECO:0000269

metaR RE0926E
is version of: http://identifiers.org/ec-code/3.2.1.1
modifier: MODEL1310110011#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.17
is described by: ECO:0000000
reactant: MODEL1310110011#
name: RE0926
kinetic law: MODEL1310110011#
reversible: true
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110011#_851d2f6a_78d6_447b_aff6_a4333a9242e9
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6576
initial amount: NaN
name: SLC25A1
initial concentration: NaN
is: D9HTE9
boundary condition: true

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaR PAIL4P HStn
reactant: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110011#
reversible: true
is described by: ECO:0000000
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
type: Reaction

metaR C81CRNe
kinetic law: MODEL1310110011#
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octenoyl carnitine into the extra cellular space
type: Reaction

metaM m5masnC g
is: HMDB00968
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C52H87N2O40X CHARGE: 0
boundary condition: false
constant: false
is: CHEBI:58282
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
is: SBO:0000247

metaM psyl e
constant: false
initial amount: NaN
notes: FORMULA: C9642006H15428700O8667414 CHARGE: 0
boundary condition: false
is: HMDB03402
initial concentration: 1.0
type: Species
has only substance units: false
name: psyllium
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110011#_6ec01269_35a1_4f74_a189_3ad4c26f2f19
type: Species
constant: false
is: P22413
initial amount: NaN
boundary condition: true
is encoded by: hsa:5167
name: ENPP1
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM hexe3coa m
initial concentration: 1.0
boundary condition: false
constant: false
name: 3-hexenoylcoa
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: HMDB06522

metaM e4hglu m
constant: false
is: CHEBI:6331
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
initial concentration: 1.0
is: HMDB02273
type: Species
has only substance units: false
is: SBO:0000247
name: erythro-4-hydroxy-L-glutamate(1-)
boundary condition: false
initial amount: NaN

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaR r2362
type: Reaction
name: Organic anion transporter 5 Utilized transport
fast: false
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110011#

metaR 3HKYNAKGAT
reactant: MODEL1310110011#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.6.1.64
is version of: http://identifiers.org/ec-code/2.6.1.7
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
fast: false
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
is: SBO:0000176
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110011#_f26ddb9a_940e_4cd7_a6d5_6fedf5185e3d
name: ADCY10
has only substance units: false
is: F5GWS5
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:55811
constant: false
initial amount: NaN

metaM dgsn e
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
type: Species
is: CHEBI:17172
initial concentration: 1.0
name: Deoxyguanosine
constant: false
is: HMDB00085
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
is: C00330

http://identifiers.org/biomodels.db/MODEL1310110011#_38679d17_ffac_4d99_8e48_b38a3c9a8dee
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:2819
initial amount: NaN
initial concentration: NaN
name: GPD1
constant: false
has only substance units: false
is: F8W1L5

metaR UDPDOLPT L
is described by: ECO:0000000
reactant: MODEL1310110011#
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
kinetic law: MODEL1310110011#
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
product: MODEL1310110011#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.117
reversible: false
modifier: MODEL1310110011#
fast: false

metaM nrvnccoa c
boundary condition: false
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: nervonyl coenzyme A
is: SBO:0000247
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
is: C16532

http://identifiers.org/biomodels.db/MODEL1310110011#_c8dbf384_7e5e_4c86_b1bb_29d0b5a42cc6
boundary condition: true
type: Species
constant: false
initial concentration: NaN
name: GCK
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q53Y25
is encoded by: hsa:2645

metaM asp L e
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: CHEBI:29991
is: SBO:0000247
has only substance units: false
name: L-aspartate(1-)
is: HMDB00191
initial concentration: 1.0
boundary condition: false

metaM C05957 r
has only substance units: false
boundary condition: false
is: HMDB02710
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:27485
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
name: Prostaglandin J2
constant: false

metaR RPI
type: Reaction
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
product: MODEL1310110011#
kinetic law: MODEL1310110011#
modifier: MODEL1310110011#
fast: false
name: ribose-5-phosphate isomerase
reactant: MODEL1310110011#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.1.6
is described by: ECO:0000000

metaR r0497
reactant: MODEL1310110011#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
modifier: MODEL1310110011#
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
kinetic law: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/1.2.4.2
is: SBO:0000176
reversible: true
product: MODEL1310110011#

metaR CYTK6n
modifier: MODEL1310110011#
kinetic law: MODEL1310110011#
product: MODEL1310110011#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
type: Reaction
name: cytidylate kinase (CMP,CTP),nuclear
is described by: ECO:0000269
reactant: MODEL1310110011#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110011#_d45c78ad_9ad7_4948_9ddf_35bf9bf08191
is: P00533
name: EGFR
constant: false
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:1956
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM CE1925 e
type: Species
name: 3'-carboxy-alpha-chromanol
is: SBO:0000247
is: CHEBI:12947
notes: FORMULA: C16H21O4 CHARGE: -1 INCHI: InChI=1/C16H22O4/c1-9-10(2)15-12(11(3)14(9)19)5-7-16(4,20-15)8-6-13(17)18/h19H,5-8H2,1-4H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1925
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110011#_5f108210_0b3c_4ef5_bb42_1fb7802679bf
is: P27707
name: DCK
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:1633
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true

metaM stcoa c
initial amount: NaN
boundary condition: false
is: C00412
is: SBO:0000247
has only substance units: false
type: Species
name: Stearoyl-CoA (n-C18:0CoA)
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: HMDB01114
initial concentration: 1.0
constant: false
is: CHEBI:57394

metaR MERCPLACCYSt
reversible: false
product: MODEL1310110011#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110011#
reactant: MODEL1310110011#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
name: 3-mercaptolactate-cysteine disulfide transport, extracellular

metaM dnad n
initial amount: NaN
type: Species
has only substance units: false
name: Deamino-NAD+
is: CHEBI:18304
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 INCHI: InChI=1S/C21H26N6O15P2/c22-17-12-18(24-7-23-17)27(8-25-12)20-16(31)14(29)11(41-20)6-39-44(36,37)42-43(34,35)38-5-10-13(28)15(30)19(40-10)26-3-1-2-9(4-26)21(32)33/h1-4,7-8,10-11,13-16,19-20,28-31H,5-6H2,(H4-,22,23,24,32,33,34,35,36,37)/p+1/t10-,11-,13-,14-,15-,16-,19-,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
is: HMDB01179
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR VALt5m
reversible: true
kinetic law: MODEL1310110011#
type: Reaction
name: Valine reversible mitochondrial transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
fast: false
product: MODEL1310110011#
reactant: MODEL1310110011#
is described by: ECO:0000000

metaM 3hodcoa m
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB06294
is: SBO:0000247
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
has only substance units: false
initial amount: NaN
constant: false
name: (S)-3-Hydroxyoctadecanoyl-CoA

metaR r1559
kinetic law: MODEL1310110011#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110011#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110011#

metaM glcur e
boundary condition: false
name: D-glucuronate
is: HMDB00127
initial concentration: 1.0
type: Species
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
constant: false
initial amount: NaN
is: CHEBI:15748
is: SBO:0000247
has only substance units: false