metaR DM ethamp r
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaM ahcys m
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00939
is: C00021
is: CHEBI:16680
type: Species
has only substance units: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
name: S-Adenosyl-L-homocysteine
initial amount: NaN
constant: false

metaR NACHEX25ly
fast: false
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110009#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
type: Reaction
modifier: MODEL1310110009#
name: beta-N-acetylhexosaminidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110009#_ba8f3b3d_fc17_47fc_ab0e_086319196d73
initial amount: NaN
boundary condition: true
name: ATP5B
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is: P06576
is encoded by: hsa:506

http://identifiers.org/biomodels.db/MODEL1310110009#_35242242_148a_4bb1_8d37_86212f5ccede
type: Species
is: SBO:0000252
is: P22234
constant: false
initial concentration: NaN
is encoded by: hsa:10606
has only substance units: false
boundary condition: true
initial amount: NaN
name: PAICS

http://identifiers.org/biomodels.db/MODEL1310110009#_dfe3942a_ceb6_4ced_8e2a_d20a7f080b19
type: Species
is encoded by: hsa:7355
boundary condition: true
has only substance units: false
initial concentration: NaN
name: SLC35A2
constant: false
is: P78381
is: SBO:0000252
initial amount: NaN

metaM 2mcit e
is: HMDB00379
has only substance units: false
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
name: 2-methylcitrate(3-)
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: CHEBI:15598
initial amount: NaN

metaR r0570
reactant: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
fast: false
reversible: true
product: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
is described by: ECO:0000000
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/6.3.3.2

metaR r1717
name: Y+LAT2 Utilized transport
reversible: false
is described by: ECO:0000000
fast: false
modifier: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR r0784
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.38
is: SBO:0000176
fast: false
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
is described by: ECO:0000000
product: MODEL1310110009#
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_79f7d8c3_bcb1_4e1a_ba68_281816915648
initial concentration: NaN
boundary condition: true
is: P24666
initial amount: NaN
name: ACP1
is: SBO:0000252
type: Species
is encoded by: hsa:52
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_a9b1a62e_6c0e_481f_aa4b_dfe5b7b05672
is: Q9H3H5
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1798
initial concentration: NaN
has only substance units: false
constant: false
name: DPAGT1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_4ccc22b7_fcc6_4527_b122_981b429e9c02
boundary condition: true
initial amount: NaN
name: BCKDHB
initial concentration: NaN
is: SBO:0000252
is: P21953
type: Species
has only substance units: false
is encoded by: hsa:594
constant: false

metaR NMNATr
product: MODEL1310110009#
name: nicotinamide-nucleotide adenylyltransferase
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.1
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
modifier: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#

metaR G14T4g
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
product: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000000
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_bddfde46_df7c_44d7_b28e_638209a96d90
type: Species
initial concentration: NaN
has only substance units: false
is: P00568
is encoded by: hsa:203
is: SBO:0000252
initial amount: NaN
constant: false
name: AK1
boundary condition: true

metaR PI4PLCn
kinetic law: MODEL1310110009#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110009#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.11
name: phosphatidylinositol 4-phosphate phospholipase C, nucleus
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_ae815151_c4d1_4f6c_9fe4_e3fc9766ef25
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5281
is: Q07326
is: SBO:0000252
type: Species
name: PIGF
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_ffc430ec_21cd_4eb1_b7dc_d5f6f3b74104
is encoded by: hsa:1716
type: Species
has only substance units: false
constant: false
name: DGUOK
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR THRGLYexR
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000304
name: L-threonine/glycine reversible exchange
reactant: MODEL1310110009#

metaM CE2420 m
is: SBO:0000247
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
is: HMDB11123
constant: false
boundary condition: false
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
type: Species
has only substance units: false
is: CHEBI:28387
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_63af8b7f_119d_4bd7_811b_48d256fc4b70
is: SBO:0000252
name: SLC46A1
boundary condition: true
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:113235
is: Q96NT5

http://identifiers.org/biomodels.db/MODEL1310110009#_7c8d3e5c_cd67_4f37_95ec_b9b84ae562df
is: Q9NVS9
is encoded by: hsa:55163
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
name: PNPO
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_547da4b3_d194_4764_82c8_73af2dbac5e9
name: ADCY3
is encoded by: hsa:109
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: B3KT86

metaR PPAt
product: MODEL1310110009#
fast: false
reversible: false
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000000
name: Propionate transport, diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
type: Reaction

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaR r1090
reactant: MODEL1310110009#
product: MODEL1310110009#
reversible: false
fast: false
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaR XOLDIOLONEt
fast: false
is: SBO:0000185
kinetic law: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110009#
name: lipid, flip-flop intracellular transport
reversible: true
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_83b8860a_4f58_4a1b_a4be_f75f340e6aed
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: SLC5A9
is: E9PAK4
is encoded by: hsa:200010
type: Species
constant: false
boundary condition: true

metaR r1650
fast: false
is described by: ECO:0000000
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
product: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaR AGTim
is: SBO:0000176
kinetic law: MODEL1310110009#
type: Reaction
is described by: ECO:0000269
fast: false
product: MODEL1310110009#
modifier: MODEL1310110009#
reactant: MODEL1310110009#
reversible: false
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
is version of: http://identifiers.org/ec-code/2.6.1.44

metaR r0497
reversible: true
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
kinetic law: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
type: Reaction
modifier: MODEL1310110009#
fast: false
is version of: http://identifiers.org/ec-code/1.2.4.2
is described by: ECO:0000000
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39

http://identifiers.org/biomodels.db/MODEL1310110009#_b2757208_f56f_470d_af0a_e7521b4a828e
initial concentration: NaN
name: BPNT1
is encoded by: hsa:10380
constant: false
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: O95861
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_9d90a1a2_7cf6_4a45_a56c_5b2e22979a9d
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:293
is: Q6I9V5
name: SLC25A6
initial amount: NaN
is: SBO:0000252

metaM 2mcit c
has only substance units: false
initial amount: NaN
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
is: HMDB00379
name: 2-methylcitrate(3-)
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:15598
constant: false
is: SBO:0000247

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaM nadh m
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/3306
name: Nicotinamide adenine dinucleotide - reduced
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57945
is: HMDB01487
is: C00004
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_ff806385_87e8_4d4f_a17c_c61d449616b1
is: A8K5J1
name: UMPS
is encoded by: hsa:7372
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM 13dampp c
initial concentration: 1.0
name: trimethylenediaminium
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
initial amount: NaN
is: HMDB00002
type: Species
constant: false
is: CHEBI:57484
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR RE3001M
kinetic law: MODEL1310110009#
reversible: true
is described by: ECO:0000000
name: RE3001
fast: false
is: SBO:0000176
product: MODEL1310110009#
reactant: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.34

metaR GTHP
reversible: true
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
fast: false
name: glutathione peroxidase
is version of: http://identifiers.org/ec-code/1.11.1.12
is version of: http://identifiers.org/ec-code/1.11.1.15
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000176
modifier: MODEL1310110009#
is described by: ECO:0000134
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.9

metaM biliverd c
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB01008
is: CHEBI:57991
has only substance units: false
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
constant: false
name: biliverdin(2-)

metaM hxcoa c
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
is: SBO:0000247
is: HMDB13130
type: Species
initial amount: NaN
name: Hexanoyl-CoA (n-C6:0CoA)
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_2d91fbde_3050_42c9_9584_e76735347302
type: Species
initial concentration: NaN
is encoded by: hsa:10476
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: A0PJH2
name: ATP5H
constant: false
has only substance units: false

metaR RE2954C
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
is described by: ECO:0000000
product: MODEL1310110009#
is: SBO:0000176
reactant: MODEL1310110009#
name: RE2954
is version of: http://identifiers.org/ec-code/2.7.1.40
reversible: true
modifier: MODEL1310110009#
fast: false

metaM Ssq23epx r
name: (S)-2,3-epoxysqualene
is: CHEBI:15441
type: Species
is: HMDB01188
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054

metaM sucsal m
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
constant: false
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57706
name: Succinic semialdehyde
is: SBO:0000247
is: HMDB01259

http://identifiers.org/biomodels.db/MODEL1310110009#_79003948_77d0_459b_b15e_8b555c0a5147
is encoded by: hsa:50484
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
constant: false
name: RRM2B
is: SBO:0000252
has only substance units: false
is: Q7LG56

metaM ksi deg8 l
name: keratan sulfate I, degradation product 8
initial amount: NaN
is: HMDB00143
constant: false
is: CHEBI:12936
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C194H311N13O171S10 CHARGE: -10

metaR VALtec
type: Reaction
fast: false
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reversible: true
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110009#
name: L-valine transport via diffusion (extracellular to cytosol)

metaR NDPK5n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false
reversible: true
modifier: MODEL1310110009#
is: SBO:0000176
reactant: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
kinetic law: MODEL1310110009#

metaR RE1903R
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110009#
fast: false
name: RE1903
reactant: MODEL1310110009#
reversible: true
product: MODEL1310110009#
is: SBO:0000176

metaM dmhptcrn c
type: Species
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: 2,6 dimethylheptanoyl carnitine
has only substance units: false
is: HMDB06320

metaM gal l
is: HMDB00143
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:12936
name: D-galactose
constant: false
has only substance units: false

metaR r0787
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
modifier: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.1
kinetic law: MODEL1310110009#

metaR TYR3MO2
fast: false
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.14.16.2
type: Reaction
modifier: MODEL1310110009#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7054.1) or (7054.3) or (7054.2) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.16.2 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9920892 NOTES:SAB unlumped form based on PMID 10727395
is: SBO:0000176
product: MODEL1310110009#
reversible: false
name: tyrosine 3-monooxygenase

http://identifiers.org/biomodels.db/MODEL1310110009#_7bcad980_6e82_4cee_bc09_261ec2398054
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
name: _H45672_1_m
is encoded by: hsa:H45672
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_9875c1d8_44f4_4deb_ae34_87998220af86
is encoded by: hsa:AU149534
name: _AU149534_1_e
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false

metaM ksi deg29 l
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
has only substance units: false
name: keratan sulfate I, degradation product 29
is: HMDB00143
is: CHEBI:12936

metaR MGCHrm
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
reversible: true
is: SBO:0000176
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/4.2.1.18
reactant: MODEL1310110009#
fast: false
is described by: ECO:0000269
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110009#_ead785b7_a20f_4dd8_9b9a_4b86a6e97d5e
boundary condition: true
initial amount: NaN
is encoded by: hsa:43
type: Species
name: ACHE
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

metaM hs deg12 l
initial amount: NaN
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: heparan sulfate, degradation product 12
is: HMDB01352
is: CHEBI:17180
constant: false
is: SBO:0000247
type: Species

metaR RE0830C
is described by: ECO:0000000
name: RE0830
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction

metaR PHYTt
fast: false
type: Reaction
reversible: true
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
product: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000185
kinetic law: MODEL1310110009#
is described by: ECO:0000000

metaR EX malt LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltose exchange
type: Reaction

metaR CRNtx
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
type: Reaction
product: MODEL1310110009#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110009#
fast: false
name: carnitine transport peroxisome to mitochondria
reactant: MODEL1310110009#

metaR r1652
reversible: true
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000185
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_946b6b87_f11d_4985_b235_e47126216f32
is encoded by: hsa:5150
name: PDE7A
initial amount: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR r0788
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110009#
is: SBO:0000176
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is described by: ECO:0000000
product: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110009#_f4ac36a7_d3cd_4f94_af95_1bf8053f185c
has only substance units: false
name: ST3GAL4
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:6484
is: Q6IBE6
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_e9bf375b_9972_42d8_a337_80dfcab52de5
name: EHHADH
constant: false
has only substance units: false
is: Q9NY65
is encoded by: hsa:1962
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM C02470 c
name: Xanthurenic acid
is: HMDB00881
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
initial concentration: 1.0
constant: false
is: C02470
type: Species
is: http://identifiers.org/pubchem.compound/5485
has only substance units: false

metaM ha deg1 l
is: CHEBI:16336
initial amount: NaN
constant: false
has only substance units: false
type: Species
name: hyaluronan degradation product 1
boundary condition: false
notes: FORMULA: C22H33N2O16 CHARGE: -1
initial concentration: 1.0
is: SBO:0000247

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

metaM ksi deg13 l
is: CHEBI:57455
is: SBO:0000247
name: keratan sulfate I, degradation product 13
notes: FORMULA: C174H280N12O150S8 CHARGE: -8
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: HMDB01354
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_8400e686_b25c_420a_97a8_b6d7af34d1d2
initial amount: NaN
boundary condition: true
name: MTMR3
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:8897
has only substance units: false

metaM HC02213 c
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
is: SBO:0000247
is: CHEBI:28031
constant: false
name: prostaglandin-e3
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_0736dcaf_a926_4943_a47b_ac127fb5cd79
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:4247
is: Q10469
type: Species
initial concentration: NaN
name: MGAT2
initial amount: NaN
boundary condition: true

metaR r1651
product: MODEL1310110009#
modifier: MODEL1310110009#
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_d273950c_463e_4625_878c_adcf1bf7b7ef
is: SBO:0000252
has only substance units: false
constant: false
name: SLC27A2
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: O14975
is encoded by: hsa:11001

metaR r0789
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: true
modifier: MODEL1310110009#
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
kinetic law: MODEL1310110009#
type: Reaction
fast: false

metaM dem2emgacpail prot hs r
is: HMDB06219
name: deacylated-(phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
is: D00348
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C37H70N3O34P3FULLRCO2FULLR2CO2X CHARGE: 0
is: http://identifiers.org/pubchem.compound/7847414
initial concentration: 1.0
initial amount: NaN
constant: false

metaM csn c
is: SBO:0000247
name: cytosine
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00630
constant: false
is: CHEBI:16040
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)

http://identifiers.org/biomodels.db/MODEL1310110009#_b16119b0_ad98_4d84_ace2_4307a601d4ed
boundary condition: true
has only substance units: false
initial amount: NaN
name: MTMR1
is: Q13613
constant: false
is: SBO:0000252
is encoded by: hsa:8776
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_89b82b8d_6abf_4301_b19a_7302e2db6cb8
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:4695
initial concentration: NaN
is: O43678
name: NDUFA2
type: Species
has only substance units: false

metaR r0575
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000176
reactant: MODEL1310110009#
reversible: true
fast: false
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.1.48

metaM thcholstoic c
initial amount: NaN
boundary condition: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
has only substance units: false
is: CHEBI:18402
is: SBO:0000247
is: HMDB03873
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_4c680055_6d22_4e49_850e_a3bdb3288ca7
boundary condition: true
name: GUCY2C
constant: false
initial amount: NaN
is encoded by: hsa:2984
has only substance units: false
initial concentration: NaN
is: P25092
type: Species
is: SBO:0000252

metaR SPHK21c
is version of: http://identifiers.org/ec-code/2.7.1.91
fast: false
name: sphingosine kinase 2
type: Reaction
is described by: ECO:0000269
reversible: false
product: MODEL1310110009#
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
reactant: MODEL1310110009#

metaM HC01434 x
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:58931
initial concentration: 1.0
name: oxalatosuccinate(3-)
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379

metaR r1654
product: MODEL1310110009#
is: SBO:0000185
kinetic law: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaR S6T2g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110009#
reversible: false
kinetic law: MODEL1310110009#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110009#
fast: false
type: Reaction
reactant: MODEL1310110009#

metaM dutp c
is: HMDB01191
type: Species
is: CHEBI:17625
is: SBO:0000247
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: C00460
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: dUTP
constant: false
initial amount: NaN

metaR FAOXC143C123x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_d05276da_316b_4f42_b1d9_a4d20bd31338
type: Species
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: RHAG
is: Q96E98
is encoded by: hsa:6005

metaM hs deg16 l
is: HMDB02704
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
constant: false
boundary condition: false
is: CHEBI:21338
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: heparan sulfate, degradation product 16
has only substance units: false
type: Species

metaR RE3568C
reactant: MODEL1310110009#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is: SBO:0000176
name: RE3568
product: MODEL1310110009#

metaR CO2tm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
product: MODEL1310110009#
is: SBO:0000185
kinetic law: MODEL1310110009#
name: CO2 transport (diffusion), mitochondrial
fast: false
reversible: true
reactant: MODEL1310110009#
is described by: ECO:0000000
type: Reaction

metaR BUTt2r
fast: false
name: Butyrate transport via proton symport, reversible
reversible: true
type: Reaction
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
reactant: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000269

metaM ahcys r
notes: FORMULA: C14H20N6O5S CHARGE: 0 INCHI: InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
initial concentration: 1.0
constant: false
is: HMDB00939
name: S-adenosyl-L-homocysteine
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:16680
initial amount: NaN
has only substance units: false

metaM csn e
has only substance units: false
is: SBO:0000247
is: CHEBI:16040
initial amount: NaN
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
type: Species
initial concentration: 1.0
boundary condition: false
name: cytosine
is: HMDB00630
constant: false

metaM creat c
is: CHEBI:16919
initial concentration: 1.0
is: HMDB00064
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
constant: false
name: creatine
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR r1653
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110009#_0105e579_e104_4c4a_b381_5339782cc7ce
is: SBO:0000252
name: OGDHL
is: Q9ULD0
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:55753
has only substance units: false
constant: false
initial amount: NaN

metaM HC02213 e
is: SBO:0000247
is: CHEBI:28031
constant: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
name: prostaglandin-e3
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_3bc33471_9df8_4e0d_9083_fb69d455ad24
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:642502
initial concentration: NaN
name: _642502_1_c
has only substance units: false
type: Species

metaR FAOXC184C163x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_044391f2_e87c_4913_ae63_55b0ee228397
is: SBO:0000252
has only substance units: false
name: CHAT
initial concentration: NaN
is: Q6LEN6
initial amount: NaN
is encoded by: hsa:1103
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_19a3a379_8081_47bf_acce_e336019b3ac2
constant: false
boundary condition: true
is encoded by: hsa:53
name: ACP2
is: E9PCI1
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM xol7ah2 m
boundary condition: false
initial concentration: 1.0
name: 5beta-cholestane-3alpha,7alpha-diol
is: CHEBI:28047
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
initial amount: NaN
type: Species
is: HMDB06893
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_b19ccb7b_498c_4d72_9250_25a65c1c9d42
name: _U37519_1_e
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:U37519
type: Species

metaR r0683
type: Reaction
reversible: false
kinetic law: MODEL1310110009#
is described by: ECO:0000000
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM sphgn c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: sphinganine(1+)
constant: false
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
is: CHEBI:57817
is: HMDB00269

metaM dolmanp U r
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
type: Species
is: CHEBI:15809
is: SBO:0000247
constant: false
has only substance units: false
name: Dolichyl phosphate D-mannose, human uterine homolog
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR r1959
reversible: false
modifier: MODEL1310110009#
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110009#
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#

metaM nadh c
is: HMDB01487
has only substance units: false
is: C00004
type: Species
is: http://identifiers.org/pubchem.compound/3306
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide - reduced
initial amount: NaN
is: CHEBI:57945
is: SBO:0000247
constant: false
boundary condition: false

metaM c12dc c
name: dodecanedioyl carnitine
initial amount: NaN
initial concentration: 1.0
is: HMDB00623
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C19H34NO6 CHARGE: -1
type: Species

metaR TRIOK
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.28 Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reversible: false
product: MODEL1310110009#
name: triokinase
type: Reaction
reactant: MODEL1310110009#
is: SBO:0000176
fast: false

metaR FAOXC184C163m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C18:4-->C16:3)m
type: Reaction

metaM c8crn e
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
is: C02838
is: HMDB00791
name: octanoyl carnitine
constant: false
notes: FORMULA: C15H29NO4 CHARGE: 0
initial concentration: 1.0

metaR DM atp c
reversible: false
name: DM_atp(c)
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
kinetic law: MODEL1310110009#
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110009#
is described by: ECO:0000134

metaR KSII CORE4tly
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110009#
name: keratan sulfate II (core 4) transport, extracellular to lysosome
reactant: MODEL1310110009#
fast: false
type: Reaction
reversible: false
product: MODEL1310110009#

metaR DMHPTCRNt
type: Reaction
kinetic law: MODEL1310110009#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES:dmhptcoa is 'special' because its biochemical fat isn't known NJ
product: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
is described by: ECO:0000000
name: 2,6 dimethylheptanoyl crn transport

metaR CSNATer
modifier: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
is: SBO:0000176
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.7
notes: GENE_ASSOCIATION: (1384.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:11257506,PMID:3759988 NOTES:mm
product: MODEL1310110009#
type: Reaction
is described by: ECO:0000254
reversible: true
name: carnitine O-acetyltransferase, endolasmic reticulum

metaR NACHEXA22ly
product: MODEL1310110009#
reactant: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
kinetic law: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
name: beta-N-acetylhexosaminidase A, lysosomal

metaM creat e
initial amount: NaN
boundary condition: false
is: HMDB00064
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
type: Species
constant: false
is: CHEBI:16919
has only substance units: false
initial concentration: 1.0
name: creatine
is: SBO:0000247

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaM vacccrn c
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
name: Vaccenyl carnitine
initial concentration: 1.0
boundary condition: false
is: HMDB06351
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false

metaM gal c
type: Species
is: C00124
is: CHEBI:0
constant: false
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0
boundary condition: false
name: D-Galactose
initial amount: NaN
is: HMDB00143
is: SBO:0000247
initial concentration: 1.0

metaR HEXDICOAACBP
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioyl coa
type: Reaction

metaR r0899
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
is described by: ECO:0000000
name: Amino acid transporter ATB0+ Facilitated diffusion
reactant: MODEL1310110009#
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110009#
fast: false
product: MODEL1310110009#

metaR BAAT3x
reversible: false
is described by: ECO:0000304
name: bile acid Coenzyme A: amino acid N-acyltransferase
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:third version analog added as per KEGG NJ
product: MODEL1310110009#
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_94fb89d4_5db5_44ce_a0db_5fbc727f3f86
constant: false
name: SLC16A2
boundary condition: true
is: P36021
initial amount: NaN
has only substance units: false
is encoded by: hsa:6567
type: Species
initial concentration: NaN
is: SBO:0000252

metaR AG13T5g
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110009#
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110009#
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110009#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_6cbfea0e_927f_4fd6_9187_552853e681f7
type: Species
initial amount: NaN
is: Q99519
has only substance units: false
name: NEU1
boundary condition: true
constant: false
is encoded by: hsa:4758
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_36db3587_9c70_4473_8161_733907baafaf
initial amount: NaN
is: H7C5B8
boundary condition: true
constant: false
name: NDUFB2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4708
is: SBO:0000252
type: Species

metaM c8crn c
notes: FORMULA: C15H29NO4 CHARGE: 0
is: C02838
is: HMDB00791
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
name: octanoyl carnitine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_4b246d1f_2e6c_4db1_9d21_0046ca1189d5
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: PYCR1
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:5831
boundary condition: true
is: A6NFM2

metaM m7masnB g
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
constant: false
is: SBO:0000247
is: C05881
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C64H107N2O50X CHARGE: 0

metaR r0686
type: Reaction
fast: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.2.2
reactant: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
reversible: true
modifier: MODEL1310110009#

metaR MECOAS1m
reversible: true
type: Reaction
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/6.2.1.4
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
product: MODEL1310110009#
fast: false
name: mesaconate--CoA ligase (GDP-forming)
is: SBO:0000176
kinetic law: MODEL1310110009#

metaM HC01434 m
type: Species
initial concentration: 1.0
name: oxalatosuccinate(3-)
has only substance units: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
boundary condition: false
is: SBO:0000247
is: CHEBI:58931
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_b995b6c2_3fcf_4a6a_b595_712c09780af1
is encoded by: hsa:4706
has only substance units: false
is: O14561
is: SBO:0000252
type: Species
boundary condition: true
name: NDUFAB1
initial amount: NaN
initial concentration: NaN
constant: false

metaR TAUBETAtc
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by beta transport system
type: Reaction

metaR DOPAt4 2 r
modifier: MODEL1310110009#
reactant: MODEL1310110009#
product: MODEL1310110009#
name: Dopamine reversible transport in via sodium symport (1:2)
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
reversible: true
kinetic law: MODEL1310110009#

metaR r0345
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110009#
fast: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.3.99.13
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110009#_d6aa35cd_c18d_4d8e_9d06_c106ae79a4da
has only substance units: false
is encoded by: hsa:27068
name: PPA2
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_658adcc2_3b1b_4669_90d1_d3d236078bcf
boundary condition: true
initial amount: NaN
is encoded by: hsa:3156
type: Species
name: HMGCR
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
is: P04035

metaR r1955
product: MODEL1310110009#
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
modifier: MODEL1310110009#
is described by: ECO:0000000
kinetic law: MODEL1310110009#
is: SBO:0000185
fast: false
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_85d306ea_6b76_4426_b38e_cc41d187b802
is encoded by: hsa:3155
type: Species
initial amount: NaN
constant: false
boundary condition: true
name: HMGCL
is: Q6IBC0
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM gal e
is: CHEBI:0
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
name: D-Galactose
is: C00124
initial amount: NaN
constant: false
is: HMDB00143
notes: FORMULA: C6H12O6 CHARGE: 0

metaR NAGLCAly
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
name: N-acetylglucosaminidase, lysosomal
type: Reaction
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
reversible: false
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_a58e7d03_5d33_4e1a_9bdc_960f7489c138
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
name: SMPD3
is encoded by: hsa:55512
constant: false
is: SBO:0000252
is: A8K0T6

metaR PMTCOAtx
type: Reaction
reactant: MODEL1310110009#
fast: false
is: SBO:0000185
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
reversible: true

metaR APRGSTRNte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
reactant: MODEL1310110009#
product: MODEL1310110009#
kinetic law: MODEL1310110009#
name: hydroxyprogesterone transport
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110009#_3f7f32e1_80b2_4af6_9b09_7aeb47eb27c8
initial concentration: NaN
constant: false
initial amount: NaN
is: B7Z7I0
name: TKTL1
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:8277
boundary condition: true

metaR ADRNCOAtx
reactant: MODEL1310110009#
name: fatty acid intracellular transport
kinetic law: MODEL1310110009#
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110009#

metaM gumtchol e
type: Species
name: guar gum-taurocholic acid complex
initial concentration: 1.0
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/93131
notes: FORMULA: C2760026H5060045NO2530007S CHARGE: 0
boundary condition: false
initial amount: NaN
has only substance units: false

metaR FAOXC143C123m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

metaM 10fthf7glu e
is: CHEBI:58190
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C50H57N13O25 CHARGE: -8
constant: false
is: HMDB00224
initial concentration: 1.0
name: 10-formyltetrahydrofolate-[Glu](7)

http://identifiers.org/biomodels.db/MODEL1310110009#_c2747cef_aacb_46cb_ba6c_d85a71ae0e52
is encoded by: hsa:89869
initial amount: NaN
is: SBO:0000252
name: PLCZ1
has only substance units: false
boundary condition: true
type: Species
is: Q86YW0
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_67f3a51e_ed32_47e9_b00c_048beeda0f5b
boundary condition: true
type: Species
is: Q16842
constant: false
is: SBO:0000252
has only substance units: false
name: ST3GAL2
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6483

metaR RE3520E
reversible: true
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.9
name: RE3520
fast: false
is: SBO:0000176
product: MODEL1310110009#
is described by: ECO:0000000

metaM ksi pre3 g
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:58053
type: Species
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 3
notes: FORMULA: C93H152N6O67X CHARGE: -1
initial amount: NaN
is: HMDB00175
is: C00130
constant: false

metaM pram c
is: HMDB01128
is: CHEBI:58681
initial concentration: 1.0
is: C03090
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
name: 5-Phospho-beta-D-ribosylamine
has only substance units: false
boundary condition: false

metaM dmhptcrn e
name: 2,6 dimethylheptanoyl carnitine
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
is: HMDB06320

metaR GLUDxm
fast: false
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.1.3
is: SBO:0000176
reversible: true
name: glutamate dehydrogenase (NAD) (mitochondrial)
product: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_776eef88_c751_4cbd_8d47_3b258ac0a988
is encoded by: hsa:1738
initial amount: NaN
name: DLD
constant: false
is: SBO:0000252
is: P09622
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true

metaR r0680
product: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
type: Reaction
kinetic law: MODEL1310110009#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.137
is described by: ECO:0000000
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000176
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33

http://identifiers.org/biomodels.db/MODEL1310110009#_a5216b01_269e_45a8_b1d0_20471dfbdc82
type: Species
is encoded by: hsa:U37519
name: _U37519_1_m
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN

metaM ksi pre33 g
is: CHEBI:58053
constant: false
initial amount: NaN
is: C00130
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 33
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB00175

metaR r1421
reversible: true
is described by: ECO:0000000
product: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is: SBO:0000185
type: Reaction
name: Free diffusion

http://identifiers.org/biomodels.db/MODEL1310110009#_0c0cfdb0_a246_4c0f_8d99_2fd52e51bd3b
is: P04746
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: AMY2A
type: Species
boundary condition: true
constant: false
is encoded by: hsa:279
initial concentration: NaN

metaR MM8Ber
notes: GENE_ASSOCIATION: (11253.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10409699,PMID:9592125 NOTES:NCD
fast: false
product: MODEL1310110009#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.113
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, endoplasmic reticulum
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_fb240baa_e18c_4dfe_8358_c3d3af11ac29
constant: false
type: Species
is: O95470
initial amount: NaN
is encoded by: hsa:8879
boundary condition: true
initial concentration: NaN
name: SGPL1
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_c58b45c4_9dad_49df_a421_0caad2b06efd
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
name: LDHB
initial concentration: NaN
is: P07195
has only substance units: false
is encoded by: hsa:3945
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_fe67c796_3b69_4cef_952f_7d3d924447e6
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:FLJ44968
initial concentration: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
name: _FLJ44968_1_m

metaM 7thf e
is: SBO:0000247
is: HMDB06559
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
name: heptaglutamyl folate (THF)
has only substance units: false
notes: FORMULA: C49H57N13O24 CHARGE: -8

metaR FPGS6m
type: Reaction
kinetic law: MODEL1310110009#
product: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
name: folylpolyglutamate synthetase (DHF), mitochondrial
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
reversible: false
is version of: http://identifiers.org/ec-code/6.3.2.17

metaR S6T18g
is version of: http://identifiers.org/ec-code/2.8.2.21
is described by: ECO:0000000
product: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.17
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
reversible: false
is: SBO:0000176
reactant: MODEL1310110009#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaM Lkynr c
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:16946
is: HMDB00684
name: L-kynurenine
is: SBO:0000247
constant: false
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328

http://identifiers.org/biomodels.db/MODEL1310110009#_dfebeaf7_1591_4489_befe_dda0f369a986
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
name: LIPC
initial concentration: NaN
is: SBO:0000252
is: A6H8L5
is encoded by: hsa:3990
type: Species

metaR RE0830N
is version of: http://identifiers.org/ec-code/4.2.1.96
name: RE0830
reactant: MODEL1310110009#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
product: MODEL1310110009#
type: Reaction
modifier: MODEL1310110009#
reversible: true
kinetic law: MODEL1310110009#
is described by: ECO:0000000

metaM CE5162 r
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162
name: trans,cis-2,9-octadecadienoyl-CoA
is: CHEBI:57923
initial concentration: 1.0
type: Species
boundary condition: false

metaR r0340
modifier: MODEL1310110009#
product: MODEL1310110009#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is described by: ECO:0000000
kinetic law: MODEL1310110009#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.38
reactant: MODEL1310110009#
reversible: false
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is: SBO:0000176

metaM h2o2 x
initial concentration: 1.0
has only substance units: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
constant: false
name: Hydrogen peroxide
is: CHEBI:16240
is: C00027
is: SBO:0000247
type: Species
is: HMDB03125
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_7c860928_3dd6_4f19_9608_9ff6dff8a8fd
has only substance units: false
initial concentration: NaN
type: Species
constant: false
name: NME1:NME2
initial amount: NaN
is encoded by: hsa:4830
boundary condition: true
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110009#_5ffe0059_63eb_4234_b789_7fa89f7365c9
type: Species
is: P40879
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1811
name: SLC26A3

metaR r0119
type: Reaction
reactant: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/5.1.3.14
kinetic law: MODEL1310110009#
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19

metaM HC01415 m
type: Species
boundary condition: false
name: (2E)-Octenoyl-CoA
is: CHEBI:27537
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276

metaR r0494
kinetic law: MODEL1310110009#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
is described by: ECO:0000000
fast: false
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5

metaR RE2445E
fast: false
reactant: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1636.1) or (59272.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.15.1 Confidence Level: 0 AUTHORS: PMID:11244003 NOTES:
is described by: ECO:0000000
name: RE2445
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.4.15.1
reversible: true
is version of: http://identifiers.org/ec-code/3.4.17.23
product: MODEL1310110009#
type: Reaction

metaR EHGLAT2m
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.1
modifier: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
is: SBO:0000176
product: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
is described by: ECO:0000304
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial

metaR r1423
name: Facilitated diffusion
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is: SBO:0000185
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
fast: false

metaM thp2c c
initial concentration: 1.0
is: HMDB12130
name: 1-piperideine-6-carboxylate
type: Species
has only substance units: false
is: CHEBI:16987
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_29ef65bf_2df8_4b8b_91ad_e5835a8c561c
constant: false
initial concentration: NaN
has only substance units: false
name: PANK3
is encoded by: hsa:79646
initial amount: NaN
is: Q9H999
is: SBO:0000252
boundary condition: true
type: Species

metaR EX 3ddcrn
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

metaR GLCter
reversible: true
is: SBO:0000185
reactant: MODEL1310110009#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
kinetic law: MODEL1310110009#
type: Reaction
name: glucose transport, endoplasmic reticulum
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_80e09902_5593_4ece_bf4f_81d27facb48e
is encoded by: hsa:6482
boundary condition: true
constant: false
name: ST3GAL1
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN

metaR r0129
is described by: ECO:0000000
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
product: MODEL1310110009#
modifier: MODEL1310110009#
fast: false
type: Reaction
kinetic law: MODEL1310110009#
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110009#_51c74062_43ed_4725_b818_03614a7384ec
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:5831
type: Species
name: PYCR1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: A6NFM2

metaM h2o2 n
constant: false
initial amount: NaN
type: Species
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125
has only substance units: false
boundary condition: false
name: hydrogen peroxide
is: SBO:0000247
is: CHEBI:16240
initial concentration: 1.0

metaM mi3p D c
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m0/s1
constant: false
is: HMDB06814
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:58401
is: SBO:0000247
initial amount: NaN
name: 1D-myo-inositol 3-phosphate(2-)
boundary condition: false

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

metaM glu L c
type: Species
initial concentration: 1.0
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
has only substance units: false
constant: false
name: L-glutamate(1-)
is: SBO:0000247
boundary condition: false
is: CHEBI:29985
initial amount: NaN
is: HMDB00148

metaM hs deg20 l
name: heparan sulfate, degradation product 20
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:16126
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
type: Species

metaM lnlnca r
is: HMDB01388
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
is: CHEBI:32387
boundary condition: false
is: SBO:0000247
name: alpha-linolenate
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
has only substance units: false

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_54f8538b_e040_48d9_a961_a5a5e5548a24
initial concentration: NaN
is: B2RDZ2
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
name: RFK
is: SBO:0000252
constant: false
is encoded by: hsa:55312

metaR 13DAMPPOX
reversible: false
is described by: ECO:0000212
fast: false
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
kinetic law: MODEL1310110009#
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
product: MODEL1310110009#
type: Reaction
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.4.3.21
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.22
reactant: MODEL1310110009#

metaM clpnd c
is: HMDB06528
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: CHEBI:53488
name: clupanodonic acid

metaM thcholstoic x
type: Species
boundary condition: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: HMDB03873
has only substance units: false
is: CHEBI:18402
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
constant: false

metaR DHAAt1r
kinetic law: MODEL1310110009#
reversible: true
type: Reaction
name: dehydroascorbate transport (uniport)
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
modifier: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000269
fast: false
reactant: MODEL1310110009#
product: MODEL1310110009#

metaR C16DCc
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexadecanedioylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_03330df2_3acf_41b8_beef_84966dfdbd0f
initial amount: NaN
name: PPAP2B
has only substance units: false
is: O14495
is encoded by: hsa:8613
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial concentration: NaN

metaR GALNTg
product: MODEL1310110009#
reversible: false
modifier: MODEL1310110009#
name: GalNAc transferase, Golgi apparatus
reactant: MODEL1310110009#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.41
kinetic law: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176

metaM ksii core4 pre10 g
has only substance units: false
constant: false
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 10
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:28067
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
is: SBO:0000247

metaR DOLMANP Lter
product: MODEL1310110009#
name: dolichol-phosphate mannose flippase (liver)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is: SBO:0000185
reversible: false
reactant: MODEL1310110009#
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110009#

metaM vacccrn m
name: Vaccenyl carnitine
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
is: HMDB06351
has only substance units: false
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1

metaR r0679
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
kinetic law: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
fast: false
modifier: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110009#_18ca9b3e_0d80_4919_8843_444f81266024
is: B4DR31
type: Species
is encoded by: hsa:1808
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: DPYSL2
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_d322b6b5_7c57_4c0e_9ce8_51391bf7154a
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8034
initial amount: NaN
is: SBO:0000252
name: SLC25A16
is: P16260
has only substance units: false

metaM HC10852 r
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
name: palmitoleyl-CoA(4-)
has only substance units: false
is: CHEBI:61540

metaM cs e deg1 l
initial concentration: 1.0
constant: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
is: SBO:0000247
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
is: HMDB00868
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:57737

metaR SERGLNNaEx
type: Reaction
modifier: MODEL1310110009#
is: SBO:0000185
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110009#
reversible: false
is described by: ECO:0000269
fast: false
name: L-serine/L-glutamine Na-dependent exchange (Ser-L in)
product: MODEL1310110009#

metaM thp2c x
initial concentration: 1.0
is: CHEBI:16987
is: HMDB12130
is: SBO:0000247
name: 1-piperideine-6-carboxylate
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
constant: false
has only substance units: false

metaM mev R c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:36464
name: (R)-mevalonate
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
type: Species
is: HMDB00227
boundary condition: false

metaM n2m2nmasn l
boundary condition: false
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
initial concentration: 1.0
constant: false
notes: FORMULA: C58H96N5O40X CHARGE: 0
type: Species
is: SBO:0000247
initial amount: NaN
is: C04946
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_5e33c2a3_302b_48b4_a746_aa0d2da8a438
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: GGT3P
is encoded by: hsa:2679
constant: false
type: Species
has only substance units: false
is: SBO:0000252

metaR ICDHxm
is described by: ECO:0000134
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.41
name: Isocitrate dehydrogenase (NAD+)
product: MODEL1310110009#
reversible: false
kinetic law: MODEL1310110009#
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (3421.2 and 3420.3 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.3 and 3421.1 and 3419.1) or (3421.1 and 3419.1 and 3420.2) or (3421.2 and 3419.1 and 3420.2) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.41 Confidence Level: 0 AUTHORS: PMID:10601238,PMID:14555658 NOTES:The reaction may be reversible. Strathern shows the reactions as irreversible. IF. Biochemical, Genetic
reactant: MODEL1310110009#

metaR MI1345PP
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.56
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.1.3.86
product: MODEL1310110009#
reversible: false
is: SBO:0000176
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.36

metaM hdca r
is: HMDB00220
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
boundary condition: false
is: SBO:0000247
has only substance units: false
is: C00249
name: Hexadecanoate (n-C16:0)
initial concentration: 1.0
is: CHEBI:7896
type: Species
constant: false
initial amount: NaN

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaM h2o2 m
is: HMDB03125
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: C00027
name: Hydrogen peroxide
constant: false
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16240

metaR DGSNtm
reversible: true
product: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
name: deoyguanosine transport in mitochondria
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:3696164 NOTES:
fast: false
kinetic law: MODEL1310110009#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110009#_b4bccca1_fa26_4038_ac92_c927707a65a5
constant: false
is encoded by: hsa:3158
is: SBO:0000252
initial amount: NaN
is: P54868
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
name: HMGCS2

metaM na1 e
is: CHEBI:4541
constant: false
type: Species
is: HMDB00588
initial concentration: 1.0
notes: FORMULA: Na CHARGE: 1
boundary condition: false
has only substance units: false
name: Sodium
is: C01330
initial amount: NaN
is: SBO:0000247

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

metaM clpnd e
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
boundary condition: false
initial amount: NaN
type: Species
is: HMDB06528
has only substance units: false
constant: false
is: SBO:0000247
name: clupanodonic acid
initial concentration: 1.0
is: CHEBI:53488

http://identifiers.org/biomodels.db/MODEL1310110009#_ad6179e9_c5b0_4805_8830_17c74905c838
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
name: SULT1A1
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:6817

http://identifiers.org/biomodels.db/MODEL1310110009#_c2b28a1a_ef8d_4036_a5de_f1c529218dba
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:8654
name: PDE5A
boundary condition: true
has only substance units: false
is: G5E9C5
constant: false
initial concentration: NaN

metaR URATEt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: false
name: urate export from cytosol
product: MODEL1310110009#
is: SBO:0000185
kinetic law: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
is described by: ECO:0000000
type: Reaction

metaR r0339
fast: false
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176
modifier: MODEL1310110009#
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.1.2.22
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110009#
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:

metaM cs b deg3 l
is: CHEBI:21338
is: HMDB02704
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C37H55NO38S2 CHARGE: -4
boundary condition: false
is: SBO:0000247
type: Species
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 3

http://identifiers.org/biomodels.db/MODEL1310110009#_8851c72d_2dce_4d72_a904_26bcbba199cc
is: SBO:0000252
has only substance units: false
constant: false
name: SLC35C1
is encoded by: hsa:55343
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is: B3KQH0

metaM oh1 e
boundary condition: false
is: C01328
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB01039
has only substance units: false
initial concentration: 1.0
name: hydroxide ion
notes: FORMULA: HO CHARGE: -1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_5955453e_f12d_4cec_bd2d_17f9dbf7977a
is: P00326
is encoded by: hsa:126
initial concentration: NaN
name: ADH1C
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false

metaR AKR1C42
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.225
is described by: ECO:0000269
kinetic law: MODEL1310110009#
is: SBO:0000176
modifier: MODEL1310110009#
fast: false
type: Reaction
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110009#
product: MODEL1310110009#

metaM 3mop m
is: SBO:0000247
type: Species
name: 3-methyl-2-oxopentanoate
is: HMDB00491
is: CHEBI:28654
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN

metaR CRNCARtp
is described by: ECO:0000000
product: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
name: carnitine-acetylcarnitine carrier, peroxisomal
kinetic law: MODEL1310110009#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_7e5b42c6_05b5_4603_b046_556b99196aaf
boundary condition: true
is: Q14032
name: BAAT
is encoded by: hsa:570
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_17dd8a6f_5a09_439b_adf2_aad30fa9a914
is encoded by: hsa:23428
type: Species
has part: Q9UHI5
initial amount: NaN
is: SBO:0000297
has only substance units: false
name: SLC7A8:SLC3A2
constant: false
initial concentration: NaN
boundary condition: true

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_f794e575_1a4b_4bd4_8b96_d879ba2f376f
initial amount: NaN
is encoded by: hsa:3550
boundary condition: true
is: Q13123
initial concentration: NaN
name: IK
type: Species
constant: false
is: SBO:0000252
has only substance units: false

metaR FADtru
reactant: MODEL1310110009#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
kinetic law: MODEL1310110009#
is: SBO:0000185
reversible: false
type: Reaction
product: MODEL1310110009#
name: FAD transporter, endoplasmic reticulum

metaR STRDNCCOAtxc
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of stearidonylcoa into peroxisomes.
type: Reaction

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaR r1418
reversible: true
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
kinetic law: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reactant: MODEL1310110009#
fast: false
is described by: ECO:0000000
product: MODEL1310110009#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110009#_5eaad482_0b09_482a_a4d2_c800fd0cb6da
type: Species
is: F8WDN9
constant: false
is: SBO:0000252
has only substance units: false
name: PPA2
initial amount: NaN
boundary condition: true
is encoded by: hsa:27068
initial concentration: NaN

metaR PPCOAOm
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110009#
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
reactant: MODEL1310110009#
reversible: false
type: Reaction
kinetic law: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110009#_23f2cd45_9be8_4cb7_b7f8_40400e5c052d
is encoded by: hsa:AI620219
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
name: _AI620219_1_e
initial concentration: NaN
type: Species
has only substance units: false

metaR THRGLNNaEx
fast: false
modifier: MODEL1310110009#
product: MODEL1310110009#
reversible: false
type: Reaction
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000185
name: L-threonine/L-glutamine Na-dependent exchange (Thr-L in)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

http://identifiers.org/biomodels.db/MODEL1310110009#_e882a459_48ee_4c5a_a04c_ddb77c7d0989
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:10587
is: Q9NNW7
name: TXNRD2
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_bcc6b484_b6e9_4c40_b87a_64553bf11444
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
name: HSD11B1
is: SBO:0000252
is encoded by: hsa:3290
constant: false

metaR 4HPRO LTte
type: Reaction
fast: false
reversible: true
is: SBO:0000185
name: Transport of trans-4-hydroxy-L-proline
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110009#
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000134

metaM cs a deg3 l
initial amount: NaN
initial concentration: 1.0
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
is: HMDB00127
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:15748
constant: false
notes: FORMULA: C31H48NO32S2 CHARGE: -3
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_13450b71_f3b7_4308_8d02_284367ef3db5
is: E9PB82
boundary condition: true
name: HSD17B4
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:3295
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_e0d73c39_a836_4acf_829b_70b35635caab
name: FUT8
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2530
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
constant: false
is: Q9BYC5

metaM core4 g
is: CHEBI:16478
notes: FORMULA: C24H40N3O15X CHARGE: 0
initial concentration: 1.0
name: Core 4
type: Species
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_f3f2ca70_47d2_43e8_949a_9b39aea2b99e
name: DGKH
is: A8K0I1
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:160851
type: Species
constant: false
initial amount: NaN

metaR C101CPT1
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decenoylcarnitine
type: Reaction

metaR FOAXC122C101x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_73152c50_fb08_4dd8_9559_dcb3244d92ac
boundary condition: true
is encoded by: hsa:6470
initial concentration: NaN
name: SHMT1
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false

metaR 3AIB Dtm
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000134
name: transport of 3aib_D into mitochondria
type: Reaction
product: MODEL1310110009#

metaR INSTt2r
fast: false
product: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110009#
is: SBO:0000185
name: inositol transport in via proton symport
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:

metaR r2338
kinetic law: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
type: Reaction
reversible: true
product: MODEL1310110009#

metaR r0122
is: SBO:0000176
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110009#
name: GTP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
product: MODEL1310110009#
type: Reaction
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_f68097f0_346e_40cb_91bc_cac2a9fcc5f1
has only substance units: false
name: INPP4B
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:8821
boundary condition: true
initial concentration: NaN
type: Species
is: O15327

metaR SRTNt6 2 r
is: SBO:0000185
reversible: true
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
reactant: MODEL1310110009#
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
product: MODEL1310110009#
is described by: ECO:0000269
type: Reaction

metaM dd3coa x
name: 3-dodecenoylcoa
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
initial amount: NaN
is: HMDB04257
constant: false
is: SBO:0000247

metaR AKR1C41
is: SBO:0000176
reversible: false
type: Reaction
modifier: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.225
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
kinetic law: MODEL1310110009#
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)

metaR FORMCOAtx
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism see Verhoeven 11591435 and clayton 11356171 - added for peroxisomal oxidation of fatty acids NJ
name: formyl coa transport
product: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_3944c076_d328_45dd_ae6e_d315f4030ffa
name: SLC20A1
constant: false
has only substance units: false
type: Species
is encoded by: hsa:6574
initial amount: NaN
is: Q8WUM9
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_27e23842_9370_4ca9_9952_9bb6a0a1008b
boundary condition: true
is: O43772
type: Species
has only substance units: false
name: SLC25A20
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:788

metaM ksi pre6 g
initial concentration: 1.0
type: Species
is: HMDB00175
is: C00130
notes: FORMULA: C107H174N7O80SX CHARGE: -2
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 6
is: SBO:0000247

metaR 1PPDCRp
is described by: ECO:0000000
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
name: delta1-piperideine-2-carboxylate reductase, perixosomal
fast: false
reversible: false
is: SBO:0000176
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM

metaR DOLASNT Uer
modifier: MODEL1310110009#
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (uterus)
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: PMID:8413235,PMID:9367678 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.119
reversible: false

metaR CO2tp
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110009#
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
name: CO2 peroxisomal transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
fast: false

metaM xol7ah c
has only substance units: false
is: HMDB06892
boundary condition: false
type: Species
initial amount: NaN
name: 7alpha-hydroxy-5beta-cholestan-3-one
is: CHEBI:2290
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451

http://identifiers.org/biomodels.db/MODEL1310110009#_cf65f35d_2062_463f_8b06_1a5244fcb52a
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is: B1AK53
initial amount: NaN
constant: false
is encoded by: hsa:83715
name: ESPN

metaR TCYNTtm
product: MODEL1310110009#
fast: false
reversible: false
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110009#
name: Thiocyanate transport via diffusion (mitochondrial)

metaR ORNt4m
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#
name: ornithine mitochondrial transport exchange with citruline
is: SBO:0000185
is described by: ECO:0000269
fast: false
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
type: Reaction

metaR AMETtd
is: SBO:0000185
reversible: true
product: MODEL1310110009#
is described by: ECO:0000134
type: Reaction
name: diffusion of S-Adenosyl-L-methionine
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110009#
fast: false

metaR ASNtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
product: MODEL1310110009#
reversible: false
reactant: MODEL1310110009#
is: SBO:0000185
name: L-asparagine transport, mitochondrial
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110009#

metaR r1643
product: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
modifier: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r2333
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110009#
is: SBO:0000185
type: Reaction
product: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#

metaM ksii core2 deg8 l
constant: false
notes: FORMULA: C36H60N3O25X CHARGE: 0
is: HMDB00143
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:12936
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 8

metaM ins c
name: Inosine
boundary condition: false
has only substance units: false
is: HMDB00195
initial amount: NaN
is: CHEBI:17596
type: Species
initial concentration: 1.0
constant: false
is: C00294
is: SBO:0000247
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294

http://identifiers.org/biomodels.db/MODEL1310110009#_4775e61f_3334_4666_8da6_81915b05e977
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:47
name: ACLY
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false

metaM ins e
is: HMDB00195
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: Inosine
constant: false
is: C00294
is: CHEBI:17596
boundary condition: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_32e0948e_881b_48a8_b35d_f6cd8d10c414
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:271
is: E9PNG0
initial concentration: NaN
initial amount: NaN
type: Species
name: AMPD2

metaR FAOXC180
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
product: MODEL1310110009#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110009#
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110009#
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110009#_9373912c_f87e_4a34_a49b_6132adb4ec07
has only substance units: false
constant: false
is encoded by: hsa:53354
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
name: PANK1
is: Q8TE04

metaM for c
initial concentration: 1.0
is: HMDB00142
has only substance units: false
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
name: Formate
boundary condition: false
initial amount: NaN
type: Species
is: C00058
is: SBO:0000247
constant: false
is: CHEBI:15740

metaM glu L l
is: CHEBI:29985
name: L-glutamate(1-)
boundary condition: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00148

metaM pydx5p e
initial amount: NaN
boundary condition: false
notes: FORMULA: C8H8NO6P CHARGE: -2 INCHI: InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)/p-2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
name: pyridoxal 5'-phosphate(2-)
type: Species
is: HMDB01491
is: SBO:0000247
constant: false
is: CHEBI:597326
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_910530ad_75ad_4ef8_b0c5_8f4698af8787
name: LYZL1
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q6UWQ5
is encoded by: hsa:84569

metaM cholate c
initial concentration: 1.0
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
constant: false
is: HMDB00619
name: Cholate
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:29747
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_ffb2eeb4_78ad_41ad_aa43_5ff5b8acb0bb
boundary condition: true
is: Q8N5Z0
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:51166
has only substance units: false
name: AADAT
constant: false
type: Species

metaM lgnc e
name: lignocerate
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:31014
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
initial concentration: 1.0
is: HMDB02003
constant: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_2a2b4499_d2dc_45ca_a4f7_460b02aa275e
name: PIP4K2B
boundary condition: true
initial amount: NaN
constant: false
is: P78356
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:8396

metaR PPAm
is described by: ECO:0000269
reversible: false
product: MODEL1310110009#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.6.1.1
fast: false
kinetic law: MODEL1310110009#
name: inorganic diphosphatase
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF

metaR r2332
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110009#
fast: false

metaR ME1m
reversible: false
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110009#
type: Reaction
name: malic enzyme (NAD), mitochondrial
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.38
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
product: MODEL1310110009#
fast: false

metaR r2099
type: Reaction
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
reversible: true
fast: false
product: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r1644
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110009#
is: SBO:0000185
modifier: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
reversible: true

metaR GALASE11ly
reversible: false
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110009#
reactant: MODEL1310110009#

metaR r0791
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
product: MODEL1310110009#
is: SBO:0000176
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
kinetic law: MODEL1310110009#

metaR CYOOm3
fast: false
reactant: MODEL1310110009#
reversible: false
product: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.9.3.1
type: Reaction
name: cytochrome c oxidase, mitochondrial Complex IV
kinetic law: MODEL1310110009#

metaR FACOAL150
product: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110009#
name: fatty-acid--CoA ligase
fast: false
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110009#_54172505_5555_449b_a92c_366309ffd2c8
name: PDXK
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:8566
is: O00764
initial amount: NaN
has only substance units: false
constant: false

metaR r2098
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110009#
reversible: true
product: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction

metaR r1645
modifier: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110009#
reversible: true
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM pydx5p c
constant: false
boundary condition: false
notes: FORMULA: C8H8NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
initial amount: NaN
is: C00018
type: Species
name: Pyridoxal 5'-phosphate
has only substance units: false
is: HMDB01491
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:597326

metaM for e
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
name: formate
is: CHEBI:15740
is: HMDB00142
initial amount: NaN
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058

metaR r2096
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR ARACHDtr
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
type: Reaction
product: MODEL1310110009#
fast: false
name: intracellular transport
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110009#_35e38bdf_052f_4824_a9e4_f27b84ca111c
is encoded by: hsa:6579
name: SLCO1A2
has only substance units: false
initial amount: NaN
is: P46721
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true

metaM CE1935 e
constant: false
is: HMDB02329
name: spermine monoaldehyde
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H26N3O CHARGE: 3 INCHI: InChI=1/C10H23N3O/c11-5-3-8-12-6-1-2-7-13-9-4-10-14/h10,12-13H,1-9,11H2/p+3 EHMN_ABBREVIATION: CE1935
is: CHEBI:30623
has only substance units: false
boundary condition: false

metaM cholate e
initial concentration: 1.0
constant: false
is: HMDB00619
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: SBO:0000247
initial amount: NaN
name: Cholate
boundary condition: false
has only substance units: false
is: CHEBI:29747
type: Species

metaM prist x
is: HMDB00795
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
initial amount: NaN
has only substance units: false
is: CHEBI:51340
type: Species
boundary condition: false
name: pristanic acid
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_78702801_6122_4c19_9479_a54a08775175
is: Q99944
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:80864
name: EGFL8
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN

metaM lgnc c
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
is: CHEBI:31014
initial concentration: 1.0
is: HMDB02003
boundary condition: false
constant: false
name: lignocerate
has only substance units: false

metaM thcholstoic r
initial concentration: 1.0
constant: false
is: HMDB03873
has only substance units: false
type: Species
is: CHEBI:18402
is: SBO:0000247
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
boundary condition: false
initial amount: NaN

metaM h2o2 e
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
constant: false
is: CHEBI:16240
name: hydrogen peroxide
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB03125
has only substance units: false
boundary condition: false

metaR r2097
kinetic law: MODEL1310110009#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110009#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110009#
fast: false
modifier: MODEL1310110009#

metaR r1646
fast: false
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000185

metaR r2334
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110009#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
fast: false
product: MODEL1310110009#
kinetic law: MODEL1310110009#

metaR FBA
product: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: true
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
fast: false
name: fructose-bisphosphate aldolase
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.2.13
is described by: ECO:0000134

metaR MTHFD2
name: methylenetetrahydrofolate dehydrogenase (NAD)
is described by: ECO:0000134
reversible: true
modifier: MODEL1310110009#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
fast: false
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.5.4.9
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaR NTP3e
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110009#
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.6.1.6
fast: false
name: nucleoside-triphosphatase (GTP)
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_01440b22_446b_4af8_a1d5_9f49373c26d3
has only substance units: false
type: Species
is: B4DG68
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4842
boundary condition: true
initial concentration: NaN
name: NOS1

metaR ATPS4m
reactant: MODEL1310110009#
name: ATP synthase (four protons for one ATP)
is version of: http://identifiers.org/ec-code/3.6.3.14
is: SBO:0000185
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000134
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.14
type: Reaction
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (513.1 and 498.2 and 506.1 and 509.2 and 514.1 or 498.2 and 513.2 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 514.2 and 506.1 or 498.2 and 513.2 and 506.1 and 509.2 and 514.1 or 513.2 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 498.1 and 506.1 and 509.2 and 514.1 or 513.1 and 498.2 and 514.2 and 506.1 and 509.2 or 513.1 and 498.2 and 509.1 and 506.1 and 514.1 or 498.2 and 509.1 and 513.2 and 506.1 and 514.1 or 513.2 and 498.1 and 506.1 and 509.2 and 514.1 or 513.2 and 514.2 and 506.1 and 509.2 and 498.3 or 513.2 and 506.1 and 509.2 and 498.3 and 514.1 or 513.1 and 509.1 and 506.1 and 498.3 and 514.1 or 509.1 and 513.2 and 514.2 and 506.1 and 498.3 or 513.1 and 498.2 and 509.1 and 514.2 and 506.1 or 513.1 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 506.1 and 514.1 or 513.1 and 506.1 and 509.2 and 498.3 and 514.1 or 509.1 and 513.2 and 506.1 and 498.3 and 514.1 or 513.1 and 514.2 and 506.1 and 509.2 and 498.3 or 509.1 and 513.2 and 498.1 and 506.1 and 514.1 or 513.1 and 509.1 and 514.2 and 506.1 and 498.3 or 498.2 and 509.1 and 513.2 and 514.2 and 506.1 or 509.1 and 513.2 and 498.1 and 514.2 and 506.1) and (10632.1 and 4905.1 and 10476.1 and 9551.3 and 522.5 and 516.2 and 521.1 and 515.1 or 518.3 and 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 9551.3 and 522.3 or 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 517.2 and 9551.2 and 522.3 or 10632.1 and 4905.1 and 10476.1 and 522.5 and 9551.2 and 518.2 and 521.1 and 515.1 or 4905.1 and 515.2 and 10476.2 and 516.2 and 521.1 and 10632.1 and 9551.3 and 522.5 or 518.3 and 4905.1 and 9551.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 522.4 or 10632.1 and 4905.1 and 10476.1 and 9551.1 and 522.2 and 515.2 and 518.2 and 521.1 or 518.3 and 10632.1 and 4905.1 and 10476.1 and 515.3 and 9551.2 and 522.4 and 521.1 or 10632.1 and 4905.1 and 10476.1 and 515.3 and 522.2 and 9551.3 and 518.2 and 521.1 or 4905.1 and 9551.1 and 10476.2 and 522…
is version of: http://identifiers.org/ec-code/3.6.4.6
fast: false

metaR EX mag hs LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Monoacylglycerol 2 (homo sapiens) exchange
type: Reaction

metaR r2095
modifier: MODEL1310110009#
is: SBO:0000185
kinetic law: MODEL1310110009#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
fast: false

metaR r1647
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110009#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reversible: true
product: MODEL1310110009#

metaM 3hibutcoa m
is: CHEBI:28259
name: (S)-3-Hydroxyisobutyryl-CoA
constant: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01052
type: Species
is: SBO:0000247

metaM dutp n
type: Species
name: dUTP
initial amount: NaN
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB01191
boundary condition: false
is: CHEBI:17625

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaR G14T18g
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110009#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110009#
reversible: false
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reactant: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false

metaR RE3074X
is described by: ECO:0000000
name: RE3074
notes: GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:11060359,PMID:11356164 NOTES:IT - fixed proton
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: true
is: SBO:0000176
fast: false
modifier: MODEL1310110009#
type: Reaction

metaR FALDtm
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: formaldehyde transport via diffusion (mitochondrial)
fast: false
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
reversible: true
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM

metaR RE3000M
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110009#
product: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
reversible: true
name: RE3000
reactant: MODEL1310110009#
fast: false

metaM ksi deg32 l
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00143
boundary condition: false
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
name: keratan sulfate I, degradation product 32
constant: false
initial amount: NaN
is: CHEBI:12936

metaM n2m2nmasn e
has only substance units: false
is: C04946
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C58H96N5O40X CHARGE: 0
initial amount: NaN

metaR r2094
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
product: MODEL1310110009#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110009#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110009#_e46cca66_e903_4568_9904_a23d7f6bcb09
is: SBO:0000252
is encoded by: hsa:6532
is: P31645
initial amount: NaN
initial concentration: NaN
name: SLC6A4
boundary condition: true
constant: false
type: Species
has only substance units: false

metaR r0792
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
type: Reaction
reactant: MODEL1310110009#
product: MODEL1310110009#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
fast: false

metaM dutp m
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17625
name: dUTP
has only substance units: false
constant: false
is: HMDB01191

metaR GLYSNAT5tc
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR r1648
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reversible: true
product: MODEL1310110009#
is: SBO:0000185
modifier: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_64119413_f0f5_4226_8231_7edc583b5c27
is: A6NED0
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: GSTZ1
has only substance units: false
is encoded by: hsa:2954
initial concentration: NaN
type: Species
constant: false

metaM na1 c
has only substance units: false
name: Sodium
initial amount: NaN
is: CHEBI:4541
is: C01330
is: HMDB00588
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: Na CHARGE: 1

metaR GTHO
reactant: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.8.1.7
reversible: false
is: SBO:0000176
name: glutathione oxidoreductase
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
modifier: MODEL1310110009#
type: Reaction
fast: false
kinetic law: MODEL1310110009#

metaR NACHEX14ly
modifier: MODEL1310110009#
fast: false
is: SBO:0000176
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110009#
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_20d5d4ee_9d64_4b7b_abf4_e47deac83ad0
has only substance units: false
is: Q969K7
is encoded by: hsa:113452
boundary condition: true
initial amount: NaN
constant: false
name: TMEM54
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_13c4c2ed_d8c2_4f34_929c_2dfd7e558960
boundary condition: true
name: ITPKA
has only substance units: false
is: P23677
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:3706
initial concentration: NaN
type: Species

metaM thcholstoic m
has only substance units: false
is: HMDB03873
is: CHEBI:18402
type: Species
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
boundary condition: false
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_ad9c2949_867f_4873_b0b0_22d3f4382df3
has only substance units: false
name: ARSB
constant: false
is encoded by: hsa:411
initial amount: NaN
is: P15848
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_d4cbf1c2_a243_44d1_84fd_5cba27344758
type: Species
is encoded by: hsa:594
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: BCKDHB
is: P21953
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_63098188_b92f_480c_9812_7de2577ffa58
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1351
boundary condition: true
name: COX8A
is: Q53XN1
initial concentration: NaN
type: Species

metaR DHORD9
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000269
reversible: false
name: dihydoorotic acid dehydrogenase (quinone10)
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.3.5.2
fast: false
reactant: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )

metaR 4HGLSDm
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/1.5.1.12
modifier: MODEL1310110009#
fast: false
is: SBO:0000176
reactant: MODEL1310110009#
product: MODEL1310110009#
reversible: true
kinetic law: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial

metaR DTMPK
fast: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.4.9
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110009#
reversible: true
is: SBO:0000176
modifier: MODEL1310110009#
name: dTMP kinase
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_fef164af_0ed7_4ad9_a506_bb5ef909f697
is: P49448
is: SBO:0000252
is encoded by: hsa:2747
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
name: GLUD2
type: Species

metaM glu L e
constant: false
initial amount: NaN
name: L-glutamate(1-)
is: HMDB00148
type: Species
initial concentration: 1.0
is: CHEBI:29985
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025

metaM HC01496 m
constant: false
is: SBO:0000247
name: 2-Amino-3-oxoadipate
is: CHEBI:28095
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
initial concentration: 1.0
boundary condition: false
type: Species

metaR r0795
reactant: MODEL1310110009#
fast: false
name: Spontaneous reaction
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Unassigned EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
is described by: ECO:0000000
product: MODEL1310110009#
is: SBO:0000176
modifier: MODEL1310110009#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.225
kinetic law: MODEL1310110009#
type: Reaction

metaR r2093
type: Reaction
kinetic law: MODEL1310110009#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110009#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110009#
modifier: MODEL1310110009#
fast: false

metaR CYTK1n
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110009#
fast: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110009#
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000176

metaR r2331
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110009#
is: SBO:0000185
product: MODEL1310110009#
fast: false
reactant: MODEL1310110009#

metaR r1649
product: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110009#
reversible: true

metaR G14T3g
is described by: ECO:0000000
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
reactant: MODEL1310110009#
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90

http://identifiers.org/biomodels.db/MODEL1310110009#_0d055983_ec6d_4b78_b0b1_c81a3d5c6bbd
constant: false
is: F8W682
has only substance units: false
type: Species
is encoded by: hsa:6522
boundary condition: true
initial concentration: NaN
name: SLC4A2
initial amount: NaN
is: SBO:0000252

metaR SUCCOAPET
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaR S6TASE14ly
modifier: MODEL1310110009#
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
type: Reaction
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000000

metaR r2092
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000185
fast: false
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR CTPtn
is: SBO:0000185
fast: false
reactant: MODEL1310110009#
type: Reaction
reversible: true
name: CTP diffusion in nucleus
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
kinetic law: MODEL1310110009#

metaR SMS
fast: false
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.8.27
kinetic law: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
name: Sphingomyelin synthase (homo sapiens)
modifier: MODEL1310110009#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
product: MODEL1310110009#

metaR r2330
product: MODEL1310110009#
reactant: MODEL1310110009#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR FAOXC200180m
type: Reaction
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110009#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110009#
reactant: MODEL1310110009#

metaR RAtn3
is: SBO:0000185
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
reversible: true
name: 13-cis-retinoic acid transport, nuclear
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_3e0c462c_85ff_439b_8fd0_0815a0c01513
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI640625
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: _AI640625_1_c

metaM CE5118 m
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:57923
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species

metaM lnlncgcoa c
boundary condition: false
name: gamma-linolenoyl-CoA(4-)
is: HMDB06368
constant: false
type: Species
has only substance units: false
is: CHEBI:57363
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
initial concentration: 1.0
is: SBO:0000247

metaM man r
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16024
boundary condition: false
is: HMDB00169
type: Species
has only substance units: false
name: D-mannose
constant: false
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159

http://identifiers.org/biomodels.db/MODEL1310110009#_ee7b1406_5607_45a3_9d9c_13f83a22425f
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: GSR
type: Species
is: SBO:0000252
constant: false
is: P00390
is encoded by: hsa:2936

http://identifiers.org/biomodels.db/MODEL1310110009#_f51fd17f_0c8d_4c38_bdb0_f96a800034e4
type: Species
is: E7EML0
initial amount: NaN
is: SBO:0000252
name: SLC4A8
is encoded by: hsa:9498
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true

metaR r0584
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
modifier: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
reactant: MODEL1310110009#
reversible: true
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110009#_504bf61d_6f97_44a5_b3a5_22be72407579
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:84720
is: SBO:0000252
constant: false
name: PIGO
boundary condition: true
is: Q8TEQ8

metaR FAOXC225C226x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_7c1ce5c4_3fd1_445d_8dd7_ec21be266b70
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: P22413
is: SBO:0000252
name: ENPP1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5167

metaR CITt4 2
name: citrate transport via sodium symport
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
fast: false
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
product: MODEL1310110009#
modifier: MODEL1310110009#

metaM dgtp e
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: HMDB01440
type: Species
name: dGTP
is: CHEBI:16497
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaM pchol hs c
constant: false
is: CHEBI:16110
has only substance units: false
initial amount: NaN
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
name: Phosphatidylcholine
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_7252c1ac_020b_4d7c_9df3_58c0cb8a5e5c
type: Species
is: SBO:0000252
is encoded by: hsa:AI620219
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
name: _AI620219_1_c
initial concentration: NaN

metaR r1940
product: MODEL1310110009#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false
is: SBO:0000185

metaM ala B e
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00056
boundary condition: false
is: CHEBI:16958
type: Species
name: beta-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_d3e03f12_74ea_4d45_8ad7_57606fa71c9a
is encoded by: hsa:5213
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P08237
boundary condition: true
constant: false
name: PFKM
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_701f5969_fad2_4cea_8f36_982a29bbe9b8
is: SBO:0000252
name: NPR2
initial concentration: NaN
is encoded by: hsa:4882
has only substance units: false
is: P20594
type: Species
initial amount: NaN
boundary condition: true
constant: false

metaM hdca c
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
name: palmitate
has only substance units: false
is: CHEBI:7896
is: SBO:0000247
is: HMDB00220
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_a83758fc_4dc4_4389_95ae_c4cc9514559c
initial amount: NaN
name: ETFA:ETFB
is encoded by: hsa:2109
constant: false
has part: P13804
is: SBO:0000297
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2108

metaM na1 x
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: HMDB00588
has only substance units: false
is: CHEBI:29101
name: sodium(1+)
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330

metaR FADH2tru
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
name: FADH2 transporter, endoplasmic reticulum
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
is: SBO:0000185
fast: false

metaM acgal c
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
is: HMDB00212
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28037
type: Species
constant: false
boundary condition: false
name: N-acetyl-D-galactosamine
has only substance units: false
is: SBO:0000247

metaR GLNtm
reversible: false
reactant: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
name: L-glutamine transport via electroneutral transporter

metaM 3otdcoa m
is: HMDB03935
has only substance units: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
constant: false
initial amount: NaN
type: Species
name: 3-Oxotetradecanoyl-CoA
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:28726

http://identifiers.org/biomodels.db/MODEL1310110009#_aa99bf28_fb43_4e5c_be5b_8f2988c40b8e
is: SBO:0000297
has part: P31040
has part: O14521
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6392
constant: false
is encoded by: hsa:6389
has part: Q99643
type: Species
has part: P21912
name: SDHA:SDHB:SDHC:SDHD
initial amount: NaN
is encoded by: hsa:6390
is encoded by: hsa:6391

metaR MACOXO
name: 3-Methylimidazole acetaldehyde:NAD+ oxidoreductase
reactant: MODEL1310110009#
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110009#
reversible: false
fast: false
is described by: ECO:0000269
product: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (218.1) or (221.1) or (4129.1) or (222.1) or (220.1) SUBSYSTEM: Histidine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10344773 NOTES:SAB added 2 h to balance--not certain
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.4

metaR r0796
reversible: true
kinetic law: MODEL1310110009#
fast: false
type: Reaction
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
product: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM strdnc e
is: HMDB06547
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205608
initial amount: NaN
constant: false
has only substance units: false
is: C16300
name: stearidonic acid C18:4, n-3
boundary condition: false
type: Species
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
initial concentration: 1.0

metaR NDPK6m
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000254
kinetic law: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reversible: true
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110009#
fast: false

metaR r2090
fast: false
reversible: true
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
product: MODEL1310110009#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110009#_047e6ea5_2689_47f8_ac81_998276666f3e
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:3795
name: KHK
is: Q6IBK2

http://identifiers.org/biomodels.db/MODEL1310110009#_64466a3f_3431_4acd_997b_978afc5003e5
constant: false
is encoded by: hsa:205
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
name: AK4
initial concentration: NaN
initial amount: NaN

metaM f1a g
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: F1alpha
initial concentration: 1.0
is: HMDB02917
constant: false
is: CHEBI:17151
notes: FORMULA: C22H37N2O15X CHARGE: 0
type: Species

metaR CYTK2n
reactant: MODEL1310110009#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110009#
is described by: ECO:0000269
product: MODEL1310110009#
name: cytidylate kinase (dCMP),nuclear

metaR r0488
product: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110009#
is: SBO:0000176

metaM for m
type: Species
is: HMDB00142
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
name: formate
initial concentration: 1.0
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: SBO:0000247
is: CHEBI:15740

metaR GALASE18ly
product: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
name: beta-galactosidase, lysosomal
modifier: MODEL1310110009#

metaM lnlccrn m
initial concentration: 1.0
type: Species
initial amount: NaN
name: Linoleyl carnitine
is: SBO:0000247
is: HMDB06469
has only substance units: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
constant: false
boundary condition: false

metaM pchol hs e
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
is: SBO:0000247
type: Species
name: Phosphatidylcholine
initial concentration: 1.0
is: CHEBI:16110
constant: false

metaR AG13T18g
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_01b864e2_b267_463a_9e76_ad297fc8afd7
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q8TF08
has only substance units: false
is encoded by: hsa:170712
name: COX7B2
constant: false
initial amount: NaN
boundary condition: true

metaR r0797
type: Reaction
product: MODEL1310110009#
name: glycine N-choloyltransferase EC:2.3.1.65
is described by: ECO:0000000
reactant: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#

metaM hedepecoa m
initial amount: NaN
is: SBO:0000247
is: HMDB02288
initial concentration: 1.0
name: 2,4,7,10,13-hexadecapentenoylcoa
boundary condition: false
has only substance units: false
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
type: Species
constant: false

metaR NDPK6n
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
fast: false
reversible: true
modifier: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000176
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110009#_7b48ccfb_69dd_471b_96f6_a96a3549ed56
is: P20933
name: AGA
is encoded by: hsa:175
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_cd10ca0a_15b0_4fa4_b692_8a70f3efc5a2
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:3420
has only substance units: false
name: IDH3B
initial amount: NaN
is: SBO:0000252

metaR ALAR
is: SBO:0000176
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
name: alanine racemase
modifier: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000212
fast: false
type: Reaction
reversible: true

metaR r2091
is: SBO:0000185
reversible: true
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110009#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110009#
type: Reaction

metaM glc D r
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
type: Species
has only substance units: false
is: CHEBI:4167
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00122
is: SBO:0000247

metaM ksii core2 pre5 g
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 5
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: HMDB00175
has only substance units: false
type: Species
is: C00130
constant: false
is: CHEBI:58053
initial amount: NaN

metaR r1642
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110009#
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000185
product: MODEL1310110009#

metaM ksi deg14 l
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
is: HMDB00143
initial concentration: 1.0
boundary condition: false
is: CHEBI:12936
name: keratan sulfate I, degradation product 14

metaM hs deg14 l
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16126
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
has only substance units: false
name: heparan sulfate, degradation product 14
is: SBO:0000247
type: Species
boundary condition: false
constant: false

metaM 4nph e
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: 4-nitrophenolate
is: SBO:0000247
is: CHEBI:57917
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
is: HMDB01232
has only substance units: false
type: Species

metaM for r
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:15740
boundary condition: false
is: HMDB00142
is: C00058
initial amount: NaN
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
has only substance units: false
is: SBO:0000247
name: Formate

metaR ORETNF
type: Reaction
product: MODEL1310110009#
name: 4-oxo-retinoic acid formation (oxidation)
is: SBO:0000176
reactant: MODEL1310110009#
fast: false
reversible: false
kinetic law: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

metaM c226coa x
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
has only substance units: false
is: SBO:0000247
is: C16169
is: http://identifiers.org/pubchem.compound/47205479
boundary condition: false
name: cervonyl coenzyme A
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_37e54a6f_da87_4d53_bc38_f7785384947f
initial amount: NaN
is: SBO:0000297
boundary condition: true
is encoded by: hsa:8803
name: SUCLG1:SUCLA2
initial concentration: NaN
type: Species
has part: E5KS60
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_118d81ba_0793_4adc_898a_7dc3353ee965
initial concentration: NaN
has only substance units: false
name: SLC2A10
initial amount: NaN
type: Species
is encoded by: hsa:81031
boundary condition: true
constant: false
is: SBO:0000252
is: O95528

metaM fe3 e
name: Fe3+
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:29034
type: Species
is: HMDB12943
is: SBO:0000247
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_4129fc0f_1c0a_4353_ac75_1c2abd3418a9
is: A8K5Z0
has only substance units: false
boundary condition: true
initial concentration: NaN
name: B4GALT3
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:8703
constant: false

metaM strdnc c
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205608
initial amount: NaN
constant: false
boundary condition: false
name: stearidonic acid C18:4, n-3
initial concentration: 1.0
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: HMDB06547
is: SBO:0000247
is: C16300

metaR r1641
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110009#
fast: false
type: Reaction
modifier: MODEL1310110009#
is: SBO:0000185
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110009#

metaR MI14Ptn
name: inositol 1,4-bisphosphate nuclear transport (diffusion)
type: Reaction
product: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
is: SBO:0000185
reactant: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true

metaR GLYCLTtp
fast: false
is described by: ECO:0000000
product: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
type: Reaction
reactant: MODEL1310110009#
reversible: false
is: SBO:0000185
name: glycolate transport into peroxisome

metaM 2docopencoa x
boundary condition: false
initial amount: NaN
constant: false
name: 2,7,10,13,16-docosapentenoylcoa
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892790
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM hs deg15 l
name: heparan sulfate, degradation product 15
type: Species
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16126

http://identifiers.org/biomodels.db/MODEL1310110009#_3ecc7347_3671_433f_8c1c_b1fe2d6bb26f
type: Species
is: O00746
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4833
initial concentration: NaN
has only substance units: false
name: NME4
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_d118604c_28fc_4bcb_8102_e62e93d11b24
is: Q5HYI4
initial amount: NaN
boundary condition: true
constant: false
type: Species
name: SQLE
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6713
has only substance units: false

metaM apoC c
has only substance units: false
initial amount: NaN
is: HMDB11111
name: Apocarboxlase (no lys residue)
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:33190
type: Species
is: SBO:0000247
notes: FORMULA: XH CHARGE: 0

metaR CYStec
reactant: MODEL1310110009#
is: SBO:0000185
product: MODEL1310110009#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110009#
type: Reaction
reversible: true
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14624363,PMID:15659399 NOTES:SAB
name: L-cysteine transport via diffusion (extracellular to cytosol)

metaM HC01672 c
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C12H15N5O8P CHARGE: -1 INCHI: InChI=1S/C12H16N5O8P/c1-5(18)25-26(21,22)23-2-6-8(19)9(20)12(24-6)17-4-16-7-10(13)14-3-15-11(7)17/h3-4,6,8-9,12,19-20H,2H2,1H3,(H,21,22)(H2,13,14,15)/t6-,8-,9-,12-/m1/s1 EHMN_ABBREVIATION: C05993
is: SBO:0000247
is: CHEBI:37666
type: Species
initial concentration: 1.0
name: Acetyl adenylate

metaR r1640
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110009#
reversible: true
modifier: MODEL1310110009#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_f0d4a5db_2ab3_46f6_a67b_1bb4ee6673a0
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: ST3GAL3
has only substance units: false
is encoded by: hsa:6487
is: Q11203
type: Species
boundary condition: true

metaM HC01602 c
is: C00234
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: 10-Formyltetrahydrofolate

metaR S6T3g
reactant: MODEL1310110009#
fast: false
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.2.21
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.8.2.17
reversible: false
modifier: MODEL1310110009#
is: SBO:0000176

metaM 4nph c
has only substance units: false
is: CHEBI:57917
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
is: SBO:0000247
initial concentration: 1.0
name: 4-nitrophenolate
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: HMDB01232

http://identifiers.org/biomodels.db/MODEL1310110009#_ab31e870_dce0_4152_963f_336e04972257
constant: false
has only substance units: false
name: STS
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P08842
is encoded by: hsa:412
initial concentration: NaN

metaR RE3567C
is: SBO:0000176
name: RE3567
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110009#

metaR DM oretn n
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: 4-oxo-retonoic acid demand
type: Reaction

metaM doldp U r
is: CHEBI:15750
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C1025H1670O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
name: Dolichol diphosphate, human uterine homolog
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN

metaM dece3coa x
boundary condition: false
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
has only substance units: false
name: 3-decenoylcoa
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966

metaM c12dc x
type: Species
name: dodecanedioyl carnitine
is: HMDB11123
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: C05279
is: SBO:0000247
notes: FORMULA: C19H34NO6 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110009#_6dbe4d63_8f5a_4ae8_bacd_d38d9938f3c4
boundary condition: true
initial concentration: NaN
is: P06132
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:7389
constant: false
type: Species
name: UROD

metaM fe3 c
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: Fe CHARGE: 3
has only substance units: false
is: HMDB12943
is: SBO:0000247
name: Fe3+

metaR GLYOX
type: Reaction
is: SBO:0000176
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (3029.1) or (84264.2) or (84264.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.6 Confidence Level: 4 AUTHORS: PMID:15117945,PMID:8550579 NOTES:IF
kinetic law: MODEL1310110009#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.2.6
name: hydroxyacylglutathione hydrolase
product: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
is described by: ECO:0000269

metaM HC01104 e
is: CHEBI:61146
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
type: Species
constant: false
name: 4-nitrophenyl phosphate(2-)
initial concentration: 1.0
has only substance units: false

metaM 5dhf m
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB06487
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
initial concentration: 1.0
name: pentaglutamyl folate (DHF)
constant: false
has only substance units: false
initial amount: NaN

metaR RE0827E
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is version of: http://identifiers.org/ec-code/1.4.3.22
product: MODEL1310110009#
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110009#
reactant: MODEL1310110009#
name: RE0827
is: SBO:0000176
is described by: ECO:0000000

metaR CITt4 4
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
reversible: true
is: SBO:0000185
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
name: citrate transport via sodium symport
reactant: MODEL1310110009#
fast: false
is described by: ECO:0000006

metaR PI4PLC
kinetic law: MODEL1310110009#
is described by: ECO:0000269
name: phosphatidylinositol 4-phosphate phospholipase C
modifier: MODEL1310110009#
is: SBO:0000176
reversible: false
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.1.4.11
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
product: MODEL1310110009#

metaM dgtp c
is: HMDB01440
is: C00286
name: dGTP
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: CHEBI:16497
constant: false

metaR r1853
modifier: MODEL1310110009#
product: MODEL1310110009#
name: Y+LAT2 Utilized transport
reversible: false
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction

metaR r1700
type: Reaction
fast: false
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reversible: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR SEBACACT
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of sebacic acidd
type: Reaction

metaM hdca e
notes: FORMULA: C16H31O2 CHARGE: -1
constant: false
is: SBO:0000247
type: Species
is: CHEBI:0
has only substance units: false
is: C00249
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: Hexadecanoate (n-C16:0)
is: HMDB00220

metaR FRDPtcr
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
is described by: ECO:0000134
fast: false
reactant: MODEL1310110009#
is: SBO:0000185
product: MODEL1310110009#
kinetic law: MODEL1310110009#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
reversible: true

metaM ala B c
is: HMDB00056
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16958
name: beta-alanine
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

metaR r0587
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110009#
fast: false
reversible: true
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
reactant: MODEL1310110009#

metaR SIAT9g
is version of: http://identifiers.org/ec-code/2.4.99.9
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110009#
is: SBO:0000176
reactant: MODEL1310110009#
type: Reaction
modifier: MODEL1310110009#
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
reversible: false
product: MODEL1310110009#

metaR DASCBR
kinetic law: MODEL1310110009#
type: Reaction
reversible: false
product: MODEL1310110009#
name: dehydroascorbate reductase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.8.4.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
reactant: MODEL1310110009#
modifier: MODEL1310110009#
fast: false

metaM ditp n
boundary condition: false
is: HMDB03537
name: dITP(4-)
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
is: CHEBI:61382
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR MMSAD3m
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.27
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
reactant: MODEL1310110009#
reversible: false
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
is described by: ECO:0000269

metaR RE2759X
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (23600.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:11060344,PMID:11060359 NOTES:
name: RE2759
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.99.4
is described by: ECO:0000000
modifier: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110009#

metaM CE4794 m
is: SBO:0000247
initial concentration: 1.0
name: cis-6-dodecenoyl-CoA
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: CHEBI:57923
has only substance units: false

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaM 5dhf l
is: HMDB06487
type: Species
initial amount: NaN
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
name: pentaglutamyl folate (DHF)
boundary condition: false

metaR BTNt4i
is: SBO:0000185
fast: false
product: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
type: Reaction
name: Biotin uptake (antiport)
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
reversible: false
is described by: ECO:0000269

metaR ITCOAL1m
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
reversible: true
is described by: ECO:0000304
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#

metaR LNLNCGt
product: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000185
name: fatty acid transport via diffusion
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110009#
reversible: true
fast: false

metaR r0698
is described by: ECO:0000000
type: Reaction
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
is version of: http://identifiers.org/ec-code/3.1.2.27
reactant: MODEL1310110009#
product: MODEL1310110009#
reversible: true
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
fast: false

metaM ksii core2 l
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:17140
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
type: Species
name: keratan sulfate II (core 2-linked)
is: HMDB01644

metaR NCKt
reversible: true
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
fast: false
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
name: Na+/Ca2+-K+ exchange
product: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction

metaR SCP21cx
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of phytanoylcoa from cytosol to peroxisomes.
type: Reaction

metaM retinol cis 11 e
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: CHEBI:16302
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB06216
name: 11-cis-retinol
initial amount: NaN
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_05aaa884_7b9d_47e0_a81a_81be3f1ae9d0
boundary condition: true
constant: false
is encoded by: hsa:79143
is: SBO:0000252
has only substance units: false
name: MBOAT7
is: Q96N66
type: Species
initial amount: NaN
initial concentration: NaN

metaR r1948
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction
reversible: false
product: MODEL1310110009#
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000185
fast: false

metaR BAAT4x
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:fourth version analog added in similarity to BAAT1x, BAAT2x NJ
type: Reaction
reactant: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000176
kinetic law: MODEL1310110009#
reversible: false
name: bile acid Coenzyme A: amino acid N-acyltransferase
is described by: ECO:0000304
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_be0daec4_3140_411a_ac7c_1860f0e6cbf0
has only substance units: false
initial concentration: NaN
name: PDE8A
initial amount: NaN
is encoded by: hsa:5151
is: SBO:0000252
is: O60658
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_22f190b3_f0af_4250_8530_5180b0d91901
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:6817
name: SULT1A1
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR 2AMADPTm
kinetic law: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
type: Reaction
product: MODEL1310110009#
reversible: true
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
reactant: MODEL1310110009#
is described by: ECO:0000269
modifier: MODEL1310110009#
fast: false

metaR r1947
kinetic law: MODEL1310110009#
reversible: false
modifier: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_aaa09a18_6f5e_426f_84e0_1dc66ccff371
boundary condition: true
constant: false
is: SBO:0000252
name: GGH
is encoded by: hsa:8836
type: Species
has only substance units: false
initial concentration: NaN
is: Q92820
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_e4ad8284_0064_49c0_9de1_1545b5e34324
initial amount: NaN
is: A7E2E0
is encoded by: hsa:5293
name: PIK3CD
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
type: Species

metaR AHEXASEly
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
kinetic law: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110009#
fast: false
modifier: MODEL1310110009#

metaM ksi pre25 g
is: CHEBI:58053
is: C00130
constant: false
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 25
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
is: SBO:0000247
is: HMDB00175
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_5ae7b40c_ea2b_4da0_9e70_fa82f35e450c
boundary condition: true
is: B3KXK1
initial concentration: NaN
is encoded by: hsa:115019
has only substance units: false
constant: false
name: SLC26A9
initial amount: NaN
type: Species
is: SBO:0000252

metaR r1088
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110009#
product: MODEL1310110009#
name: Active transport
reactant: MODEL1310110009#

metaR EX chol LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Choline
type: Reaction

metaR S4TASE5ly
is described by: ECO:0000000
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.12
fast: false
is: SBO:0000176
name: N-acetylgalactosamine-4-sulfatase, lysosomal
modifier: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD

metaM dgtp n
boundary condition: false
name: dGTP
constant: false
has only substance units: false
is: CHEBI:16497
is: SBO:0000247
is: C00286
initial concentration: 1.0
is: HMDB01440
type: Species
initial amount: NaN
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286

metaM m3gacpail hs r
notes: FORMULA: C49H88NO29PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
initial amount: NaN
is: HMDB03125
is: CHEBI:16240
name: trimannosyl-glucosaminyl-acylphosphatidylinositol (H4)
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false

metaR FAOXC225C226m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

metaR EX succ LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Succinate exchange
type: Reaction

metaM gar c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB02022
is: C03838
is: CHEBI:58457
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
type: Species
name: N1-(5-Phospho-D-ribosyl)glycinamide
boundary condition: false

metaR URIt5le
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
is: SBO:0000185
modifier: MODEL1310110009#
name: uridine transport in via sodium symport (1:2)
is described by: ECO:0000134
product: MODEL1310110009#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM hs deg4 l
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
has only substance units: false
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
initial concentration: 1.0
is: CHEBI:16126
boundary condition: false
name: heparan sulfate, degradation product 4

http://identifiers.org/biomodels.db/MODEL1310110009#_d2fbe937_7627_4114_921f_f13dbc3f2b85
has only substance units: false
is encoded by: hsa:84720
type: Species
boundary condition: true
constant: false
is: SBO:0000252
name: PIGO
initial concentration: NaN
initial amount: NaN

metaM phyt2ohcoa x
is: CHEBI:57334
boundary condition: false
constant: false
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)32(50)40(54)70-20-19-43-30(49)17-18-44-38(53)35(52)41(6,7)22-63-69(60,61)66-68(58,59)62-21-29-34(65-67(55,56)57)33(51)39(64-29)48-24-47-31-36(42)45-23-46-37(31)48/h23-29,32-35,39,50-52H,8-22H2,1-7H3,(H,43,49)(H,44,53)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/t26?,27?,28?,29-,32?,33-,34-,35+,39-/m1/s1 EHMN_ABBREVIATION: C07343
type: Species
is: HMDB01295
has only substance units: false
initial concentration: 1.0
name: 2-hydroxyphytanoyl-CoA(4-)
initial amount: NaN
is: SBO:0000247

metaM retinol cis 11 c
initial amount: NaN
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
name: 11-cis-retinol
is: CHEBI:16302
constant: false
is: HMDB06216
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR ASPPROASCT1
reversible: false
name: aspartate intake by system ASCT-1 transporter
modifier: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
product: MODEL1310110009#
fast: false
is described by: ECO:0000134
is: SBO:0000185
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
kinetic law: MODEL1310110009#

metaM c4dc x
name: succinyl carnitine
initial concentration: 1.0
has only substance units: false
is: C02862
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB02013
is: http://identifiers.org/pubchem.compound/213144
notes: FORMULA: C11H18NO6 CHARGE: -1
boundary condition: false

metaR MI1PP
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110009#
reversible: false
reactant: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
is version of: http://identifiers.org/ec-code/3.1.3.25
type: Reaction
fast: false
kinetic law: MODEL1310110009#
name: myo-inositol 1-phosphatase

metaR LACZe
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase
reversible: false
reactant: MODEL1310110009#
name: b-galactosidase, extracellular
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110009#
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.108

metaR DDECE1CRNe
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of dodecenoyl carnitine into extra cellular space
type: Reaction

metaM glyc S e
notes: FORMULA: C3H5O4 CHARGE: 0
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:33871
constant: false
initial concentration: 1.0
name: (S)-Glycerate
type: Species
is: HMDB06372
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_c602fbd2_7c01_4360_a5a8_36e4c66cc45e
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q8NB10
constant: false
initial amount: NaN
is encoded by: hsa:5137
type: Species
boundary condition: true
name: PDE1C

metaR r0480
is: SBO:0000176
product: MODEL1310110009#
reversible: true
type: Reaction
reactant: MODEL1310110009#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
kinetic law: MODEL1310110009#

metaR r0580
is: SBO:0000176
reversible: true
fast: false
reactant: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
type: Reaction
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.3.99.7
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_c9afc21b_bb11_4cc5_8223_bb64391d5d50
name: GBA
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2629
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_9afaab96_6bd1_46a2_ae10_a065e51ddb84
boundary condition: true
initial concentration: NaN
is: O15245
type: Species
initial amount: NaN
name: SLC22A1
has only substance units: false
is encoded by: hsa:6580
is: SBO:0000252
constant: false

metaR C8CRNe
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octanoyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_b8d30b83_5924_48cf_b75b_52bd0eaf5562
type: Species
boundary condition: true
has only substance units: false
name: SARDH
is: A8K596
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1757

metaM orn e
type: Species
is: HMDB00214
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: SBO:0000247
boundary condition: false
name: Ornithine
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:0
has only substance units: false
is: C01602

http://identifiers.org/biomodels.db/MODEL1310110009#_2a14c755_79ec_444e_9b49_0b4d895339d5
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:224
type: Species
initial amount: NaN
constant: false
name: ALDH3A2
is: P51648

metaM udpglcur c
is: SBO:0000247
is: HMDB00935
initial amount: NaN
has only substance units: false
is: C00167
name: UDP-D-glucuronate
is: CHEBI:58052
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
boundary condition: false
type: Species
initial concentration: 1.0
constant: false

metaR C16DCe
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexadecanedioic acid mono-L-carnitine ester into extra cellular space
type: Reaction

metaM na1 r
name: sodium(1+)
initial concentration: 1.0
constant: false
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
initial amount: NaN
is: CHEBI:29101
is: SBO:0000247
has only substance units: false
is: HMDB00588
boundary condition: false
type: Species

metaR BDHm
is: SBO:0000176
kinetic law: MODEL1310110009#
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
modifier: MODEL1310110009#
type: Reaction
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.30
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
product: MODEL1310110009#
is described by: ECO:0000269
reactant: MODEL1310110009#

metaM hpdca c
boundary condition: false
is: HMDB02259
constant: false
is: SBO:0000247
name: margarate
is: CHEBI:32366
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
initial concentration: 1.0

metaR GLUDym
is: SBO:0000176
modifier: MODEL1310110009#
product: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is version of: http://identifiers.org/ec-code/1.4.1.3
is described by: ECO:0000269
name: glutamate dehydrogenase (NADP), mitochondrial
reversible: true

metaR S6TASE21ly
product: MODEL1310110009#
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
kinetic law: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
is: SBO:0000176
reactant: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000000

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

metaR GAO2g
modifier: MODEL1310110009#
reversible: false
kinetic law: MODEL1310110009#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
name: Ganglioside O-acetylation
fast: false
reactant: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000269

metaR C3STDH1r
fast: false
type: Reaction
reactant: MODEL1310110009#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ
is: SBO:0000176
reversible: false
modifier: MODEL1310110009#
name: C-3 sterol dehydrogenase (4-methylzymosterol)
is version of: http://identifiers.org/ec-code/1.1.1.170
product: MODEL1310110009#
kinetic law: MODEL1310110009#

metaR RE1254C
is: SBO:0000176
reversible: true
name: RE1254
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110009#
product: MODEL1310110009#
kinetic law: MODEL1310110009#

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaR r1435
is: SBO:0000185
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
name: Transport reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
reversible: false

metaM c5dc c
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
name: glutaryl carnitine
is: HMDB13130
has only substance units: false
boundary condition: false
notes: FORMULA: C12H21NO6 CHARGE: 0
initial concentration: 1.0

metaR G12MT1 U
reversible: false
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110009#
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
is described by: ECO:0000000
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_6d24f220_5b47_4f62_bd8a_6886f42ebb5e
name: BDH1
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:622

metaR DURItn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
reversible: true
reactant: MODEL1310110009#
name: deoxyuridine transport in nucleus
is: SBO:0000185
kinetic law: MODEL1310110009#
fast: false
is described by: ECO:0000000
product: MODEL1310110009#

metaM xol25oh r
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
is: HMDB06247
is: CHEBI:42977
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
name: 25-hydroxycholesterol
boundary condition: false
initial amount: NaN

metaM acgal l
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
type: Species
name: N-acetyl-D-galactosamine
constant: false
is: CHEBI:28037
is: SBO:0000247
is: HMDB00212
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_424acbd9_ec60_420e_a207_dff063567f61
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:6240
is: P23921
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
name: RRM1

http://identifiers.org/biomodels.db/MODEL1310110009#_1017b0e0_e206_444c_be4c_30a652d3d940
is: SBO:0000252
initial amount: NaN
name: DECR2
type: Species
initial concentration: NaN
is encoded by: hsa:26063
constant: false
has only substance units: false
is: Q9NUI1
boundary condition: true

metaM pchol hs r
boundary condition: false
name: Phosphatidylcholine
constant: false
is: CHEBI:16110
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
type: Species
initial concentration: 1.0

metaM orn c
type: Species
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: C01602
is: HMDB00214
name: Ornithine
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:0

metaR DRPA
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
fast: false
name: deoxyribose-phosphate aldolase
reversible: false
product: MODEL1310110009#

metaR RETFA
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reversible: false
type: Reaction
name: retinol acyltransferase
reactant: MODEL1310110009#
fast: false
is: SBO:0000176

metaM hdca l
is: CHEBI:7896
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: HMDB00220
name: palmitate
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR AG13T4g
is described by: ECO:0000000
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
product: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176

metaR r0483
reversible: true
type: Reaction
fast: false
product: MODEL1310110009#
reactant: MODEL1310110009#
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
kinetic law: MODEL1310110009#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110009#_97f66bd4_46e2_4e56_b8b4_b7c84b70c7af
initial amount: NaN
constant: false
is: SBO:0000252
name: PDE9A
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:5152

metaM arachdcoa c
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: HMDB06523
is: CHEBI:57368
type: Species
name: arachidonoyl-CoA(4-)
is: SBO:0000247
initial amount: NaN

metaM apoC m
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB00182
boundary condition: false
notes: FORMULA: XH CHARGE: 0
is: CHEBI:32551
type: Species
initial amount: NaN
name: Apocarboxlase (no lys residue)

metaR r1942
name: Y+LAT2 Utilized transport
reversible: false
modifier: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000185
kinetic law: MODEL1310110009#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_fe2f5fcc_9769_4b7d_b116_d77d6b8273ee
is encoded by: hsa:55967
has only substance units: false
constant: false
is: SBO:0000252
name: NDUFA12
initial concentration: NaN
boundary condition: true
is: F8VQS7
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_a181b1d4_74d8_4f47_a96b_744a44ba2f02
constant: false
boundary condition: true
has only substance units: false
type: Species
name: B3GNT2
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10678

metaM 5dhf e
is: HMDB06487
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
boundary condition: false
is: SBO:0000247
name: pentaglutamyl folate (DHF)
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_a960adf4_7608_4638_b39e_896339764ce5
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI769281
name: _AI769281_1_e
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true

metaR CO2t
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110009#
fast: false
name: CO2 transporter via diffusion
product: MODEL1310110009#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
reactant: MODEL1310110009#

metaM c5dc e
has only substance units: false
boundary condition: false
is: HMDB13130
type: Species
name: glutaryl carnitine
is: SBO:0000247
constant: false
notes: FORMULA: C12H21NO6 CHARGE: 0
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_312dc5f9_a542_437d_9cbd_c5969fc2fc70
constant: false
type: Species
boundary condition: true
name: GALNS
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: P34059
is encoded by: hsa:2588

metaR r1433
is described by: ECO:0000000
product: MODEL1310110009#
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
fast: false
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
type: Reaction

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_1852f5b7_e6ba_4015_9b02_9f34427156be
is encoded by: hsa:56606
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
name: SLC2A9
constant: false
is: SBO:0000252
is: Q9NRM0

metaR GASNASE2ly
reactant: MODEL1310110009#
modifier: MODEL1310110009#
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.26
name: glycosylasparaginase, lysosomal
reversible: false
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
product: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110009#

metaR SUBERICACT
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of suberic acid for formation of suberyl carnitine
type: Reaction

metaM tym c
constant: false
has only substance units: false
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
boundary condition: false
is: CHEBI:327995
is: HMDB00306
name: tyraminium
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_2a7a7a89_7adc_423c_92e5_6956723a9b1e
name: _U52111_1_c
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:U52111
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM pap g
is: CHEBI:58343
constant: false
type: Species
is: SBO:0000247
is: HMDB00061
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
name: adenosine 3',5'-bismonophosphate(4-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_348a43e9_afd2_4630_bbad_47fbfe3716b7
is: P26572
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:4245
name: MGAT1
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_6c3fc5dd_9cd3_4b85_8a28_fb995d44f54f
initial concentration: NaN
name: ACADM
is encoded by: hsa:34
type: Species
is: P11310
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR CYTK9
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,dCTP)
is: SBO:0000176
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reversible: true
fast: false

metaR NH4t3r
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
name: ammonia transport via proton antiport
type: Reaction
product: MODEL1310110009#
fast: false
is: SBO:0000185
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#

metaM gsn c
is: C00387
initial amount: NaN
is: SBO:0000247
type: Species
name: Guanosine
boundary condition: false
is: CHEBI:16750
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00133

http://identifiers.org/biomodels.db/MODEL1310110009#_1f307450_d875_43e2_992b_7475a8f9b986
is encoded by: hsa:79623
boundary condition: true
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: GALNT14
is: Q96FL9
initial amount: NaN

metaM acac m
is: SBO:0000247
initial concentration: 1.0
is: HMDB00060
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:13705
name: acetoacetate
type: Species
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164

metaR r1428
type: Reaction
name: Free diffusion
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
product: MODEL1310110009#
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110009#_b7d3d2fe_889b_4869_8c52_28977644146c
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:284111
type: Species
name: SLC13A5
is: Q86YT5
initial amount: NaN
constant: false
initial concentration: NaN

metaR S6TASE24ly
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
reversible: true
reactant: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction

metaR ALAASNNaEx
modifier: MODEL1310110009#
reversible: false
is: SBO:0000185
reactant: MODEL1310110009#
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)
type: Reaction
fast: false
kinetic law: MODEL1310110009#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110009#

metaM glc D e
constant: false
name: D-glucose
is: SBO:0000247
is: HMDB00122
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
type: Species
is: CHEBI:4167
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_c4becc4f_9ef8_4541_9bcd_2ec0df2be227
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:2348
initial amount: NaN
boundary condition: true
has only substance units: false
name: FOLR1

metaR GALASE12ly
reversible: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110009#
fast: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110009#
modifier: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18

http://identifiers.org/biomodels.db/MODEL1310110009#_1da35da2_373a_4686_ad62_fda67a9b6a55
name: _AI694761_1_c
is encoded by: hsa:AI694761
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_549dcf72_0b79_4f07_80aa_f3dc1102b0a3
initial amount: NaN
boundary condition: true
is encoded by: hsa:1718
is: SBO:0000252
constant: false
name: DHCR24
is: Q15392
has only substance units: false
initial concentration: NaN
type: Species

metaR r1639
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185
reactant: MODEL1310110009#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
product: MODEL1310110009#
type: Reaction

metaR CYTK8
reactant: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,dATP)
modifier: MODEL1310110009#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110009#

metaR G13MT U
modifier: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000
product: MODEL1310110009#
reactant: MODEL1310110009#
name: Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)
is version of: http://identifiers.org/ec-code/2.4.1.132
reversible: false
type: Reaction
kinetic law: MODEL1310110009#

metaR LYStiDF
is: SBO:0000185
reversible: false
fast: false
reactant: MODEL1310110009#
name: L-lysine transport via diffusion (extracellular to cytosol)
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
is described by: ECO:0000269
product: MODEL1310110009#
type: Reaction
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#

metaM man c
type: Species
has only substance units: false
constant: false
is: HMDB00169
is: C00159
is: SBO:0000247
name: D-Mannose
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16024
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_2ee4a91c_e0c9_475e_ac54_bcd1195e740f
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
name: ACAT2
is encoded by: hsa:39
is: Q9BWD1
type: Species
has only substance units: false
initial amount: NaN

metaR DOCO13EFATP
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: absorption or uptake of 13-docosenoic acid into cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_922877ba_6897_4af0_afe6_4398f94118dc
is: SBO:0000252
is encoded by: hsa:5476
initial concentration: NaN
has only substance units: false
is: P10619
boundary condition: true
initial amount: NaN
type: Species
name: CTSA
constant: false

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_ea99437b_2cb6_40f6_90c8_44a81cdd9106
name: GUSB
initial concentration: NaN
is: SBO:0000252
is: P08236
constant: false
boundary condition: true
is encoded by: hsa:2990
initial amount: NaN
type: Species
has only substance units: false

metaM bamppald c
is: http://identifiers.org/pubchem.compound/7975
is: HMDB01106
constant: false
is: SBO:0000247
boundary condition: false
type: Species
name: beta-Aminopropion aldehyde
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
is: C05665
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR SPMTDe
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
name: SPMTDe
type: Reaction
reversible: true
reactant: MODEL1310110009#
is described by: ECO:0000134
kinetic law: MODEL1310110009#
is: SBO:0000185

metaR TETDEC2CRNe
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of tetradecadienoyl carnitine into extra cellular space
type: Reaction

metaM tchola c
name: taurocholic acid
initial amount: NaN
is: HMDB00036
is: SBO:0000247
constant: false
is: CHEBI:36257
has only substance units: false
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_a9ac9774_693b_475f_8faa_5c5a28b6135f
type: Species
initial concentration: NaN
name: ALDH3B2
initial amount: NaN
is encoded by: hsa:222
boundary condition: true
has only substance units: false
is: P48448
is: SBO:0000252
constant: false

metaR C3STDH1Pr
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
is described by: ECO:0000134
modifier: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reversible: false
name: C-3 sterol dehydrogenase (4-methylzymosterol)
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.170
is: SBO:0000176
reactant: MODEL1310110009#

metaM ditp c
has only substance units: false
is: HMDB03537
initial concentration: 1.0
type: Species
name: dITP(4-)
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:61382
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345

metaR TDCRNe
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of myristoyl carnitine into extra cellular space
type: Reaction

metaR CYTK7
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110009#
is described by: ECO:0000269
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
type: Reaction
reversible: true
name: cytidylate kinase (CMP,UTP)
fast: false

metaR MMMm
is: SBO:0000176
fast: false
reversible: true
modifier: MODEL1310110009#
name: methylmalonyl-CoA mutase
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
is described by: ECO:0000269
product: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.99.2
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_b1285e40_f6a6_4e96_9cba_9e25ac20f2cb
constant: false
name: AFMID
boundary condition: true
is encoded by: hsa:125061
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: Q63HM1
is: SBO:0000252

metaM ksii core2 e
is: CHEBI:17268
is: SBO:0000247
name: keratan sulfate II (core 2-linked)
initial amount: NaN
is: HMDB00211
constant: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species

metaM msa m
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
is: HMDB11111
is: CHEBI:33190
initial concentration: 1.0
name: 3-oxopropanoate

metaM lnlncgcoa r
type: Species
initial concentration: 1.0
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: gamma-linolenoyl-CoA(4-)
is: HMDB06368
is: CHEBI:57363
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_ea1a11b5_3260_437b_b9f6_278c499c8e81
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2678
boundary condition: true
name: GGT1
constant: false
initial amount: NaN
type: Species
has only substance units: false

metaM glc D c
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: SBO:0000247
initial concentration: 1.0
is: HMDB00122
name: D-glucose
boundary condition: false
type: Species
is: CHEBI:4167

metaM orn m
is: SBO:0000247
notes: FORMULA: C5H13N2O2 CHARGE: 1
initial concentration: 1.0
name: Ornithine
is: HMDB00214
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:46912
is: C01602
initial amount: NaN
constant: false

metaM glyc S c
initial amount: NaN
name: (S)-Glycerate
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:33871
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C3H5O4 CHARGE: 0
is: HMDB06372

metaM ksi deg24 l
is: CHEBI:12936
type: Species
name: keratan sulfate I, degradation product 24
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00143
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_bc26cd4d_dbf0_4662_bf59_c0647a06de79
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2181
name: ACSL3
type: Species
has only substance units: false
is: O95573
boundary condition: true
initial amount: NaN
constant: false

metaM q10h2 c
boundary condition: false
initial amount: NaN
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
has only substance units: false
is: http://identifiers.org/pubchem.compound/6504740
initial concentration: 1.0
is: SBO:0000247
is: HMDB13111
constant: false
name: Ubiquinol-10
type: Species

metaR 2MCITt
product: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:426765 NOTES:MM
is described by: ECO:0000000
reactant: MODEL1310110009#
name: 2-methylcitrate transport via diffusion
fast: false
type: Reaction
kinetic law: MODEL1310110009#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110009#_b4c51258_1431_4c6b_bc5b_81ad3843304c
is: SBO:0000297
boundary condition: true
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
constant: false
is encoded by: hsa:518
initial concentration: NaN
has only substance units: false
initial amount: NaN
has part: P48201
type: Species

metaR r2194
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110009#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110009#
product: MODEL1310110009#
reversible: true
kinetic law: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM pap c
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
boundary condition: false
is: CHEBI:58343
initial amount: NaN
name: adenosine 3',5'-bismonophosphate(4-)
has only substance units: false
is: SBO:0000247
is: HMDB00061

metaR FAOXC225C204m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaM hpdcacrn c
type: Species
has only substance units: false
is: HMDB06210
constant: false
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
is: SBO:0000247
boundary condition: false
name: heptadecanoyl carnitine
initial concentration: 1.0
initial amount: NaN

metaR PRPPS
is version of: http://identifiers.org/ec-code/2.7.6.1
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110009#
fast: false
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
product: MODEL1310110009#
name: phosphoribosylpyrophosphate synthetase
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:

metaM lnlncgcoa x
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:57363
is: HMDB06368
initial amount: NaN
is: SBO:0000247
name: gamma-linolenoyl-CoA(4-)
has only substance units: false
constant: false

metaR FAOXC5C5DCc
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of glutaryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_a7a1464c_b9b5_48a1_bc84_865d981c562e
initial amount: NaN
constant: false
name: ALDH7A1
has only substance units: false
is: E7EPT3
boundary condition: true
type: Species
is encoded by: hsa:501
is: SBO:0000252
initial concentration: NaN

metaM prist c
type: Species
is: HMDB00795
constant: false
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
has only substance units: false
initial amount: NaN
name: pristanic acid
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:51340

metaR CHOLt4
name: choline, sodium cotransport
reversible: true
fast: false
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000269
product: MODEL1310110009#
is: SBO:0000185
reactant: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD

metaR 3HKYNAKGAT
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
reactant: MODEL1310110009#
fast: false
reversible: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.64
is version of: http://identifiers.org/ec-code/2.6.1.7
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000304

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaM lnlccrn c
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
type: Species
is: HMDB06469
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
name: Linoleyl carnitine
constant: false
initial amount: NaN

metaR r2193
product: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110009#
reversible: true
kinetic law: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

http://identifiers.org/biomodels.db/MODEL1310110009#_5c719e45_3f53_4609_b93c_4d6547c9a5cd
is encoded by: hsa:6487
name: ST3GAL3
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_0282665a_d4e8_4d34_930b_39bb61acbb35
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q3KT79
is: SBO:0000252
is encoded by: hsa:23600
constant: false
name: AMACR
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_b11ac8df_2b52_4c0a_a777_0c1420027ece
has only substance units: false
type: Species
initial amount: NaN
name: ADH7
is: SBO:0000252
is: P40394
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:131

metaM ksii core2 g
initial concentration: 1.0
type: Species
name: keratan sulfate II (core 2-linked)
initial amount: NaN
has only substance units: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: CHEBI:17140
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB01644

metaR r1429
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
kinetic law: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
name: Free diffusion
is described by: ECO:0000000
product: MODEL1310110009#

metaR r0113
fast: false
type: Reaction
product: MODEL1310110009#
reversible: false
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 0 AUTHORS: PMID:10431835,PMID:15748884,PMID:3740419,PMID:4337336,PMID:5063602,PMID:5417402,PMID:9305887,PMID:9305888 NOTES:
name: UDP-N-acetyl-D-glucosamine 2-epimerase Aminosugars metabolism EC:5.1.3.14
modifier: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/6.2.1.1
kinetic law: MODEL1310110009#

metaR EX hista LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Histamine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_6da18a44_3bb4_4261_a226_5b1b004be909
is: Q9UF12
is: SBO:0000252
is encoded by: hsa:58510
initial amount: NaN
name: PRODH2
boundary condition: true
has only substance units: false
constant: false
type: Species
initial concentration: NaN

metaM q10h2 e
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/6504740
boundary condition: false
name: Ubiquinol-10
is: SBO:0000247
is: HMDB13111
constant: false
initial amount: NaN
has only substance units: false

metaR r2197
reactant: MODEL1310110009#
product: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110009#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaR ADRNt
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110009#
reversible: true
name: fatty acid transport via diffusion
type: Reaction

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

metaM dmhptcrn m
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB06320
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
name: 2,6 dimethylheptanoyl carnitine
has only substance units: false
initial amount: NaN
type: Species

metaR EX ptdca LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentadecanoate exchange
type: Reaction

metaR r0688
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
product: MODEL1310110009#
modifier: MODEL1310110009#
fast: false
reactant: MODEL1310110009#

metaM chlstol r
has only substance units: false
is: HMDB06842
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
initial amount: NaN
type: Species
boundary condition: false
name: 5alpha-cholesta-7,24-dien-3beta-ol
constant: false
is: CHEBI:16290
is: SBO:0000247
initial concentration: 1.0

metaM core6 g
initial concentration: 1.0
notes: FORMULA: C16H27N2O10X CHARGE: 0
constant: false
name: Core 6
type: Species
is: CHEBI:16478
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false

metaM acac e
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
name: acetoacetate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: CHEBI:13705
type: Species
is: HMDB00060
initial concentration: 1.0
initial amount: NaN

metaR ALASERNaEx
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
reversible: false
modifier: MODEL1310110009#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110009#
name: L-alanine/L-serine Na-dependent exchange (Ala-L in)
product: MODEL1310110009#
reactant: MODEL1310110009#

metaR LALDO
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110009#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
product: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
is version of: http://identifiers.org/ec-code/1.1.1.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_cb9b2806_f3e4_43f4_8685_64b210124838
has part: P16499
is encoded by: hsa:5149
type: Species
is encoded by: hsa:5145
initial amount: NaN
has only substance units: false
is: SBO:0000297
has part: B7Z9T9
has part: Q13956
is encoded by: hsa:5158
boundary condition: true
name: PDE6A:PDE6H:PDE6B
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_c4dfffcf_5aef_4e5c_8929_df23bd378f79
is: B2RAT6
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:2592
constant: false
is: SBO:0000252
name: GALT
initial amount: NaN

metaR PAIL HStn
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: phosphatidylinositol nuclear transport (diffusion)
product: MODEL1310110009#
type: Reaction
reversible: true
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_de050ac2_da84_41d0_88f8_1f53623418e5
has only substance units: false
type: Species
is: P11310
is encoded by: hsa:34
initial concentration: NaN
initial amount: NaN
name: ACADM
constant: false
boundary condition: true
is: SBO:0000252

metaR IDOAASE3ly
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.76
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
modifier: MODEL1310110009#
type: Reaction
name: alpha-L-iduronidase, lysosomal
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110009#
is: SBO:0000176

metaR r2196
fast: false
is described by: ECO:0000000
reactant: MODEL1310110009#
modifier: MODEL1310110009#
product: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r2195
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110009#
product: MODEL1310110009#
modifier: MODEL1310110009#
reversible: true
fast: false
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

http://identifiers.org/biomodels.db/MODEL1310110009#_e550fc25_4b94_4c9d_9ae5_4ddba2705dd4
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P19404
is encoded by: hsa:4729
constant: false
name: NDUFV2
type: Species

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaM c4dc c
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: C02862
is: http://identifiers.org/pubchem.compound/213144
type: Species
notes: FORMULA: C11H18NO6 CHARGE: -1
is: HMDB02013
has only substance units: false
name: succinyl carnitine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_44dd387a_6056_4b94_9658_91191143189e
is: F8W7V3
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9551
is: SBO:0000252
name: ATP5J2
has only substance units: false
boundary condition: true

metaM m7masnB r
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: C05881
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C64H107N2O50X CHARGE: 0
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
boundary condition: false

metaR N2M2NMASNtly
product: MODEL1310110009#
reactant: MODEL1310110009#
reversible: false
name: n2m2nmasn transport, extracellular to lysosome
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaR FAOXC61C4m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

metaM HC01522 c
has only substance units: false
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
constant: false
is: SBO:0000247
name: Gentisate aldehyde
is: CHEBI:28508
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false

metaR 4NPHSULT
is: SBO:0000176
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.8.2.1
is described by: ECO:0000269
fast: false
reversible: false
product: MODEL1310110009#
type: Reaction
name: 4-Nitrophenol Sulfotransferase
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)

metaM acac c
is: HMDB00060
is: CHEBI:13705
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
name: acetoacetate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
constant: false

metaR C121CPT1
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecenoylcarnitine
type: Reaction

metaM pnto R c
has only substance units: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
initial concentration: 1.0
is: CHEBI:7916
is: SBO:0000247
constant: false
is: HMDB00210
boundary condition: false
initial amount: NaN
type: Species
name: (R)-Pantothenate

metaR ORNt3m
is: SBO:0000185
product: MODEL1310110009#
fast: false
type: Reaction
name: ornithine mitochondrial transport via proton antiport
kinetic law: MODEL1310110009#
reversible: true
modifier: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is described by: ECO:0000269

metaM lnlncgcoa m
name: gamma-linolenoyl-CoA(4-)
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
initial concentration: 1.0
initial amount: NaN
is: HMDB06368
is: CHEBI:57363
boundary condition: false
type: Species
is: SBO:0000247
constant: false

metaR r2085
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR SUCCCROT
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of succinyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_ee53a13f_133e_4ff1_aecf_ccb083cd1b12
constant: false
is: SBO:0000252
has only substance units: false
is: Q8N3T1
is encoded by: hsa:117248
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: GALNTL2
type: Species

metaR r1633
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110009#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
product: MODEL1310110009#
reversible: true
type: Reaction
reactant: MODEL1310110009#

metaR r0268
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.1.3.1
is: SBO:0000176
type: Reaction
reactant: MODEL1310110009#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.2
fast: false
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
kinetic law: MODEL1310110009#
reversible: true
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2

metaR r2199
is described by: ECO:0000000
kinetic law: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110009#
reversible: true
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
modifier: MODEL1310110009#
reactant: MODEL1310110009#

metaR r2086
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110009#
reversible: true
product: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_03f60a54_e336_47a6_a906_8cc4ea4a0e7d
has only substance units: false
initial amount: NaN
constant: false
name: MUT
is: SBO:0000252
is: P22033
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4594
type: Species

metaR CYTK2
is: SBO:0000176
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
product: MODEL1310110009#
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110009#
name: cytidylate kinase (dCMP)

metaR r2347
fast: false
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110009#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
product: MODEL1310110009#
type: Reaction
reversible: true

metaR S6TASE1ly
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
reversible: true
kinetic law: MODEL1310110009#
fast: false
reactant: MODEL1310110009#

metaR IVCOAACBP
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Isovaleryl-CoA from mitochondria into cytosol
type: Reaction

metaR r2084
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR r1634
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
is: SBO:0000185

metaR r2198
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
modifier: MODEL1310110009#
is described by: ECO:0000000
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#
is: SBO:0000185

metaR r2346
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110009#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
fast: false
product: MODEL1310110009#

metaR S6T4g
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110009#
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#

metaR PEPCKm
product: MODEL1310110009#
name: Phosphoenolpyruvate carboxykinase (GTP)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/4.1.1.32
is: SBO:0000176
modifier: MODEL1310110009#
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_a0773655_021f_4731_bdab_c7b07fe50aea
type: Species
constant: false
initial concentration: NaN
boundary condition: true
name: LDHC
is encoded by: hsa:3948
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR r0267
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
modifier: MODEL1310110009#
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.5.1.9
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110009#_97de5a66_f0b1_4625_8d23_f0b1df40536e
type: Species
is: P28330
is encoded by: hsa:33
initial concentration: NaN
has only substance units: false
constant: false
name: ACADL
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR CYTK1
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110009#
is: SBO:0000176
name: cytidylate kinase (CMP)
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000269
modifier: MODEL1310110009#

metaR r0579
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.13.11.19
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176
product: MODEL1310110009#
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_29298808_547b_4a65_bb49_10c4b7ed002a
initial concentration: NaN
initial amount: NaN
is: Q1LZ56
constant: false
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:206358
is: SBO:0000252
name: SLC36A1

metaM HC01408 m
initial amount: NaN
name: 3-Oxohexanoyl-CoA
type: Species
is: SBO:0000247
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
is: CHEBI:27648
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_84c492c1_d52b_4c46_b026_3f6e61581875
type: Species
constant: false
name: BCKDHB
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:594
is: Q9BQL0
initial amount: NaN
boundary condition: true

metaR ME2m
type: Reaction
kinetic law: MODEL1310110009#
reversible: false
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.40
is version of: http://identifiers.org/ec-code/1.1.1.38
is: SBO:0000176
name: malic enzyme (NADP), mitochondrial
product: MODEL1310110009#
reactant: MODEL1310110009#
modifier: MODEL1310110009#
fast: false

metaM nadh r
initial concentration: 1.0
is: CHEBI:57945
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
constant: false
name: NADH(2-)
is: HMDB01487
boundary condition: false
type: Species

metaM CE5161 r
type: Species
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA
boundary condition: false
is: CHEBI:57923
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_e201c6a2_48b7_4ac8_8de1_e91df7509b7f
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4723
has only substance units: false
type: Species
constant: false
is: SBO:0000252
is: E5KNH5
name: NDUFV1
initial amount: NaN

metaM ksi deg35 l
is: HMDB00143
is: CHEBI:12936
name: keratan sulfate I, degradation product 35
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C68H113N4O54S1 CHARGE: -1

metaR r2088
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110009#
modifier: MODEL1310110009#
reversible: true
type: Reaction
product: MODEL1310110009#
kinetic law: MODEL1310110009#

metaR FAOXC225C204x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_a3d475d1_f156_4bdf_8a3a_eb3f12e34b08
name: HK1
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: A8K7J7
is encoded by: hsa:3098
boundary condition: true
type: Species
is: SBO:0000252

metaR LNLCCRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
reactant: MODEL1310110009#
is described by: ECO:0000269
product: MODEL1310110009#
modifier: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
is: SBO:0000185
name: transport into the mitochondria (carnitine)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_acf82036_35ce_46b1_bba3_89a158d65244
boundary condition: true
is encoded by: hsa:3419
name: IDH3A
constant: false
is: P50213
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252

metaR r1631
product: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_252fe3e8_6ec8_4535_adb5_b0f0fd9cec97
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is: P21108
name: PRPS1L1
is encoded by: hsa:221823
initial concentration: NaN
type: Species

metaR r0578
product: MODEL1310110009#
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/4.1.2.27
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000176
fast: false

metaR NACHEX8ly
product: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction

metaM cdpea c
initial amount: NaN
name: cdpea[c]
is: HMDB01564
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C11H19N4O11P2 CHARGE: -1 INCHI: InChI=1S/C11H20N4O11P2/c12-2-4-23-27(19,20)26-28(21,22)24-5-6-8(16)9(17)10(25-6)15-3-1-7(13)14-11(15)18/h1,3,6,8-10,16-17H,2,4-5,12H2,(H,19,20)(H,21,22)(H2,13,14,18)/p-1/t6-,8-,9-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00433 EHMN_ABBREVIATION: C00570
is: CHEBI:57876
boundary condition: false
type: Species

metaR DOLPMT3 Uer
modifier: MODEL1310110009#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
product: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.1.260
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110009#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_84e79169_af66_4e13_8c39_e1455212bc2c
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2108
is: P13804
constant: false
boundary condition: true
name: ETFA
type: Species

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

metaM 5HPET c
is: CHEBI:57450
constant: false
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
type: Species
is: HMDB01193
name: 5(S)-HPETE(1-)
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM man l
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: HMDB00169
constant: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: D-mannose
is: CHEBI:16024
initial amount: NaN

metaR r2344
reversible: true
reactant: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
product: MODEL1310110009#
name: Organic anion transporter 5 Utilized transport
fast: false
kinetic law: MODEL1310110009#
type: Reaction

metaR r2087
is described by: ECO:0000000
reactant: MODEL1310110009#
reversible: true
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110009#
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110009#

metaR r1632
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110009#
fast: false
is: SBO:0000185
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110009#

metaR 3HCO3 NAt
fast: false
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110009#
reversible: true
type: Reaction
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
kinetic law: MODEL1310110009#
name: 3HCO3_NAt

metaR RE2541E
product: MODEL1310110009#
type: Reaction
fast: false
modifier: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.31
is described by: ECO:0000000
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
name: RE2541
reversible: true

metaM core6 l
boundary condition: false
constant: false
is: SBO:0000247
name: Core 6
is: CHEBI:12936
has only substance units: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
initial amount: NaN
is: HMDB00143
type: Species
initial concentration: 1.0

metaR r2081
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
product: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: true
modifier: MODEL1310110009#

metaM udpglcur r
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: CHEBI:58052
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
name: UDP-D-glucuronate
is: HMDB00935
has only substance units: false
boundary condition: false
is: C00167

http://identifiers.org/biomodels.db/MODEL1310110009#_40814c2c_ba9d_4866_8356_d0248d2a7998
constant: false
is: Q9NY59
has only substance units: false
is encoded by: hsa:55512
boundary condition: true
name: SMPD3
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN

metaM hpdcacrn m
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
is: HMDB06210
name: heptadecanoyl carnitine
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_25be93b3_3210_4afd_99b8_fe21a8ba74c2
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:6534
is: SBO:0000252
name: SLC6A7
is: Q99884
type: Species
initial amount: NaN
boundary condition: true

metaR DHORTS
is: SBO:0000176
modifier: MODEL1310110009#
reversible: true
is version of: http://identifiers.org/ec-code/2.1.3.2
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
kinetic law: MODEL1310110009#
fast: false
is described by: ECO:0000269
type: Reaction
name: dihydroorotase
reactant: MODEL1310110009#
product: MODEL1310110009#

metaR CYTK6
type: Reaction
is described by: ECO:0000269
product: MODEL1310110009#
name: cytidylate kinase (CMP,CTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reversible: true
modifier: MODEL1310110009#
is: SBO:0000176
kinetic law: MODEL1310110009#

metaR G14T17g
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
reactant: MODEL1310110009#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110009#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaM man e
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16024
name: D-Mannose
boundary condition: false
is: C00159
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: SBO:0000247
type: Species
constant: false
has only substance units: false
is: HMDB00169

metaR FAOXC61C4x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)x
type: Reaction

metaR r1637
modifier: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reversible: true
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110009#
is: SBO:0000185

metaM dolmanp U c
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
name: Dolichyl phosphate D-mannose, human uterine homolog
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: CHEBI:15809

metaR r2080
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
is: SBO:0000185
reversible: true

metaR RE1519M
type: Reaction
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.3.99.13
reversible: true
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
kinetic law: MODEL1310110009#
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110009#
name: RE1519
modifier: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_3fe7aef0_ff3e_4d58_81ce_2f54de1ba0d4
type: Species
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is: P56556
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4700
name: NDUFA6

metaR PROt4 2 r
is described by: ECO:0000006
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110009#
name: Proline transport (sodium symport) (2:1)
reactant: MODEL1310110009#
product: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
type: Reaction
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110009#_51e4847c_b7ff_44b7_bab5_fda4285a1e23
initial concentration: NaN
is encoded by: hsa:5152
boundary condition: true
constant: false
name: PDE9A
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_d5503ee6_2ec4_45eb_992c_cda93d39f6cc
name: PDE9A
is encoded by: hsa:5152
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_4d8b6e6f_3ad1_4037_bc4d_0b51eb07da99
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8818
type: Species
constant: false
name: DPM2
has only substance units: false

metaR CYTK5
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
reactant: MODEL1310110009#
name: cytidylate kinase (dCMP)
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110009#_d41f89eb_7e90_4a7f_8474_80ad2d1b3f3f
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3141
name: HLCS
is: P50747
boundary condition: true

metaR r1638
modifier: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110009#
is: SBO:0000185
reversible: true
product: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction

metaM q10h2 m
type: Species
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/6504740
is: HMDB13111
has only substance units: false
boundary condition: false
name: Ubiquinol-10
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
initial amount: NaN
is: SBO:0000247

metaR r2083
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110009#
type: Reaction
modifier: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#

metaR FAOXC164C163x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_28942cbb_ba57_4db2_ba89_f486efbc4c13
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: GCNT1
constant: false
has only substance units: false
type: Species
is encoded by: hsa:2650
is: Q02742

metaR DDECCRNe
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of lauroyl carnitine into extra cellular space
type: Reaction

metaM pnto R e
boundary condition: false
is: CHEBI:7916
name: (R)-Pantothenate
constant: false
has only substance units: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: SBO:0000247
is: HMDB00210
initial concentration: 1.0
initial amount: NaN
type: Species

metaR LCTStg
product: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:this reaciton is only found in lactating mammary cells NCD
name: lactose transport from Golgi to extracellular (via vesicle)
is described by: ECO:0000000
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110009#_f48d503d_c389_434e_a9ad_6cfcc397b562
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
name: IDH3B
is encoded by: hsa:3420
boundary condition: true
constant: false

metaM cs b l
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
initial amount: NaN
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
is: CHEBI:36005
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB02183

http://identifiers.org/biomodels.db/MODEL1310110009#_ee6dace0_7ce2_4797_9f61_85025f25e2b8
is encoded by: hsa:8612
name: PPAP2C
has only substance units: false
constant: false
is: E9PAY8
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true

metaR G14T2g
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is described by: ECO:0000000
product: MODEL1310110009#
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction

metaR XYLUR
is: SBO:0000176
type: Reaction
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.10
reversible: true
name: xylulose reductase
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
kinetic law: MODEL1310110009#
is described by: ECO:0000269
product: MODEL1310110009#
fast: false

metaR r2341
kinetic law: MODEL1310110009#
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport

metaM man g
initial concentration: 1.0
is: CHEBI:16024
name: D-mannose
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
type: Species
constant: false
is: HMDB00169
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_683e8c46_ee7c_41c4_8d5f_e832998a9270
constant: false
boundary condition: true
is: Q11201
name: ST3GAL1
is encoded by: hsa:6482
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR r1635
kinetic law: MODEL1310110009#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110009#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#

metaR CYTK4
is: SBO:0000176
product: MODEL1310110009#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.4.3
name: cytidylate kinase (dCMP)(GTP)
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
reversible: true
kinetic law: MODEL1310110009#
fast: false

metaR r2082
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
fast: false
product: MODEL1310110009#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110009#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185

metaM 10fthf6glu e
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
initial concentration: 1.0
name: 10-formyltetrahydrofolate-[Glu](6)
boundary condition: false
is: CHEBI:58190
is: HMDB00224
initial amount: NaN
constant: false

metaR ST8SIA51g
type: Reaction
name: Beta-galactoside alpha-2,3-sialyltransferase
modifier: MODEL1310110009#
reversible: false
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is described by: ECO:0000269
product: MODEL1310110009#
is: SBO:0000176
fast: false

metaM glc D g
is: HMDB00122
is: CHEBI:4167
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
constant: false
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040

metaM 44mzym r
constant: false
is: HMDB01286
has only substance units: false
is: CHEBI:18364
initial amount: NaN
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: 14-demethyllanosterol
type: Species

metaM hxcoa m
is: HMDB06522
initial amount: NaN
constant: false
is: SBO:0000247
name: Hexanoyl-CoA (n-C6:0CoA)
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
type: Species

metaM ksi pre28 g
type: Species
is: HMDB00175
initial concentration: 1.0
initial amount: NaN
is: C00130
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 28
boundary condition: false
notes: FORMULA: C213H341N15O176S8X CHARGE: -9

metaR TAURtcx
is described by: ECO:0000212
kinetic law: MODEL1310110009#
reversible: true
is: SBO:0000185
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:8010975 NOTES:SAB
type: Reaction
modifier: MODEL1310110009#
fast: false
name: taurine transport (sodium symport) (cytosol to peroxisome)
product: MODEL1310110009#

metaM xol7ah2 c
type: Species
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
boundary condition: false
constant: false
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha-diol
is: CHEBI:28047
is: HMDB06893
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM 2docopencoa m
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
name: 2,7,10,13,16-docosapentenoylcoa
has only substance units: false
initial concentration: 1.0

metaM mmcoa R m
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB01269
initial amount: NaN
name: (R)-methylmalonyl-CoA(5-)
boundary condition: false
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
type: Species
is: CHEBI:57326

metaR r1636
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110009#
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110009#
is: SBO:0000185
modifier: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_44d29b22_6fc8_4fed_b0ba_0a5002fb5b4c
is encoded by: hsa:6785
initial concentration: NaN
constant: false
name: ELOVL4
has only substance units: false
is: SBO:0000252
is: Q9GZR5
initial amount: NaN
type: Species
boundary condition: true

metaR CYTK3
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.4.3
name: cytidylate kinase (CMP)(GTP)
is: SBO:0000176
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
product: MODEL1310110009#
fast: false
type: Reaction
reactant: MODEL1310110009#

metaM nadh x
is: http://identifiers.org/pubchem.compound/3306
is: HMDB01487
initial amount: NaN
is: CHEBI:57945
boundary condition: false
name: Nicotinamide adenine dinucleotide - reduced
initial concentration: 1.0
has only substance units: false
constant: false
is: C00004
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_1d002054_d0cc_4c93_81ef_762f079aff46
constant: false
initial amount: NaN
boundary condition: true
name: SLC38A3
type: Species
initial concentration: NaN
is encoded by: hsa:10991
is: Q99624
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_16f16bc2_c029_441d_bece_954220595035
type: Species
name: FOLR1
initial concentration: NaN
is encoded by: hsa:2348
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false

metaR GLUTCOAACBP
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of glutaryl-CoA(5-) from mitochondria into cytosol
type: Reaction

metaR BILDGLCURtr
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
type: Reaction
name: glucuronidated compound transport
is: SBO:0000185
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000000
reversible: true
product: MODEL1310110009#

metaR G3PD1
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.8
reactant: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
name: glycerol-3-phosphate dehydrogenase (NAD)
is described by: ECO:0000269
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2

http://identifiers.org/biomodels.db/MODEL1310110009#_6ea32acf_bdf6_4a2d_9eb2_8f4ee9f9d9ab
boundary condition: true
type: Species
is encoded by: hsa:956
name: ENTPD3
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
is: O75355
initial amount: NaN

metaR GLYCTDle
reactant: MODEL1310110009#
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110009#
type: Reaction
name: difussion of glycerol accross the brush border membrane
kinetic law: MODEL1310110009#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR GLYCTO1p
product: MODEL1310110009#
is described by: ECO:0000269
reactant: MODEL1310110009#
reversible: false
is: SBO:0000176
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
kinetic law: MODEL1310110009#
name: Glycolate oxidase, peroxisome
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.3.15

metaM tag hs c
type: Species
has only substance units: false
name: triglyceride
initial amount: NaN
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:17855

http://identifiers.org/biomodels.db/MODEL1310110009#_fe219f48_cc2f_4d47_95cd_b15fec5ec531
initial concentration: NaN
is: SBO:0000252
is: E7EX19
has only substance units: false
is encoded by: hsa:5295
boundary condition: true
constant: false
type: Species
name: PIK3R1
initial amount: NaN

metaM c4crn e
boundary condition: false
name: butyryl carnitine
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/213144
is: HMDB02013
is: C02862
is: SBO:0000247
type: Species
notes: FORMULA: C11H21NO4 CHARGE: 0

metaR UMPK6n
fast: false
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110009#
name: UMP kinase (dCTP),nuclear
type: Reaction
modifier: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
reactant: MODEL1310110009#
is described by: ECO:0000269

metaM sph1p c
is: HMDB01383
type: Species
is: CHEBI:57939
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_7e1e3d52_03aa_4930_af5a_1f204a3413f7
is encoded by: hsa:51109
is: B4DDW0
initial concentration: NaN
name: RDH11
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_fb047314_c020_4a43_8cf9_9549a21597e8
is encoded by: hsa:226
name: ALDOA
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

metaR PIACGT
reversible: false
name: phosphatidylinositol N-acetylglucosaminyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.198
reactant: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.83
product: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
is: SBO:0000176
kinetic law: MODEL1310110009#

metaR CAROtr
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
kinetic law: MODEL1310110009#
reversible: true
fast: false
name: beta-carotene transport via diffusion
is: SBO:0000185
product: MODEL1310110009#
reactant: MODEL1310110009#

metaM pail5p hs c
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:57795
is: SBO:0000247
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
type: Species

metaR CSEPASEly
reactant: MODEL1310110009#
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
type: Reaction
is described by: ECO:0000000
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
kinetic law: MODEL1310110009#
product: MODEL1310110009#

metaM itacon m
is: CHEBI:17240
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB02092
name: itaconate(2-)
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490

metaM ksi g
name: keratan sulfate I
is: SBO:0000247
constant: false
is: HMDB01644
initial amount: NaN
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: CHEBI:17140
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_771b164a_6ea0_4bf4_bc1b_841c557afcc6
initial concentration: NaN
constant: false
name: TM7SF2
is encoded by: hsa:7108
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
is: O76062
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_316ad5a0_3eba_4525_900e_1e3c9e7a4e91
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:23007
is: Q4KWH8
initial amount: NaN
type: Species
boundary condition: true
name: PLCH1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_a357fe44_3495_44e4_9ee2_57aeb32c84ae
has only substance units: false
initial concentration: NaN
constant: false
name: PANK2
is: SBO:0000252
type: Species
is encoded by: hsa:80025
initial amount: NaN
is: Q6P1K9
boundary condition: true

metaM mi1p D c
boundary condition: false
is: CHEBI:58433
is: SBO:0000247
initial amount: NaN
name: 1D-myo-inositol 1-phosphate(2-)
is: HMDB02985
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698

metaM CE5120 m
boundary condition: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
initial amount: NaN
is: SBO:0000247
name: trans-2-cis-8-tetradecadienoyl-CoA
constant: false
type: Species
is: CHEBI:57923
has only substance units: false
initial concentration: 1.0

metaR r0552
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#
is: SBO:0000176
modifier: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.3.5.1
fast: false

metaM acmanap c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H2,15,16,17)/p-2 HEPATONET_1.0_ABBREVIATION: HC01257 EHMN_ABBREVIATION: C04257
initial amount: NaN
is: HMDB01121
boundary condition: false
type: Species
is: CHEBI:58557
constant: false
name: N-acetyl-D-mannosamine 6-phosphate(2-)
has only substance units: false

metaR CYOR u10m
kinetic law: MODEL1310110009#
reversible: false
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110009#
reactant: MODEL1310110009#
modifier: MODEL1310110009#
name: ubiquinol-6 cytochrome c reductase, Complex III
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/3.5.1.92
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH

metaM tag hs e
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
has only substance units: false
name: triglyceride
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
boundary condition: false
is: CHEBI:17855
initial concentration: 1.0

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_e19793a3_30d6_464d_905f_5bb1c7d76dab
name: PPT2
is encoded by: hsa:9374
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
is: Q9UMR5
constant: false
boundary condition: true

metaR EX thym LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymine exchange
type: Reaction

metaR r1630
is: SBO:0000185
product: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_fe5be50d_0abe_4dd7_844f_5e9d583f0b73
has only substance units: false
constant: false
name: GUCY2F
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2986
is: SBO:0000252
is: P51841
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_c02c7d9e_869f_4d41_9e29_1db5895e11b2
has only substance units: false
name: UCK1
boundary condition: true
is: Q5JT09
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:83549
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_fb0611e8_8318_4fa9_811a_016f5fd68e39
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
name: CA13
is encoded by: hsa:377677
is: Q8N1Q1
boundary condition: true
type: Species
is: SBO:0000252

metaR NRPPHRSULT
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.8.2.1
reversible: false
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000176
fast: false
name: Norepinephrine Sulfotransferase
type: Reaction
modifier: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)

metaR NDPK7n
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is described by: ECO:0000304
product: MODEL1310110009#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_8cfa29ea_0cd9_45e0_921d_59eaba118902
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is: B3KQ84
is encoded by: hsa:29958
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: DMGDH

metaM malt e
type: Species
constant: false
is: CHEBI:17306
boundary condition: false
has only substance units: false
is: HMDB00163
is: C00208
initial concentration: 1.0
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
initial amount: NaN
is: SBO:0000247
name: Maltose

http://identifiers.org/biomodels.db/MODEL1310110009#_1bf586cd_0c50_4bec_a133_c0b70f4790c4
boundary condition: true
is encoded by: hsa:2987
name: GUK1
initial amount: NaN
constant: false
is: Q16774
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_85ff444d_5f2d_4b99_a8a7_edb221f121f4
is encoded by: hsa:2530
constant: false
is: SBO:0000252
has only substance units: false
name: FUT8
initial concentration: NaN
type: Species
initial amount: NaN
is: B4DFS7
boundary condition: true

metaR r0553
kinetic law: MODEL1310110009#
fast: false
reversible: true
reactant: MODEL1310110009#
is: SBO:0000176
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
type: Reaction
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is described by: ECO:0000000

metaR NH4tn
reversible: true
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
name: ammonia nuclear transport
reactant: MODEL1310110009#
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110009#
is described by: ECO:0000000

metaM c4crn c
is: C02862
name: butyryl carnitine
has only substance units: false
is: HMDB02013
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/213144
constant: false
notes: FORMULA: C11H21NO4 CHARGE: 0
boundary condition: false
type: Species
is: SBO:0000247

metaR RE0828E
fast: false
is: SBO:0000176
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
name: RE0828
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.4.3.22
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
product: MODEL1310110009#
reversible: false
type: Reaction

metaM kynate c
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
is: HMDB00715
is: SBO:0000247
name: kynurenate
boundary condition: false
is: CHEBI:58454
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0

metaM ksi e
is: CHEBI:17268
name: keratan sulfate I
is: SBO:0000247
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
constant: false
initial amount: NaN
is: HMDB00211
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species

metaM pacald c
initial concentration: 1.0
name: phenylacetaldehyde
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: CHEBI:16424
is: HMDB06236

http://identifiers.org/biomodels.db/MODEL1310110009#_cc0e24d6_d3b0_41a9_a5c9_a2ec78082976
has only substance units: false
is encoded by: hsa:10723
initial amount: NaN
name: SLC12A7
type: Species
is: Q9Y666
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252

metaM 3hddcoa c
initial amount: NaN
name: (S)-3-Hydroxydodecanoyl-CoA
boundary condition: false
type: Species
is: HMDB00623
is: SBO:0000247
has only substance units: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
initial concentration: 1.0
constant: false

metaR RE3003M
fast: false
name: RE3003
kinetic law: MODEL1310110009#
reversible: true
type: Reaction
modifier: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.3.8
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:

metaR VLCS2p
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: PMID:10479480 NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
type: Reaction
reactant: MODEL1310110009#
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
name: Very-long-chain-fatty-acid-CoA ligase
reversible: false
modifier: MODEL1310110009#
fast: false

metaR RETH
fast: false
is described by: ECO:0000000
reactant: MODEL1310110009#
reversible: false
name: retinyl ester hydrolase
type: Reaction
modifier: MODEL1310110009#
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.1.1.3
kinetic law: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT

metaR C4DCCACT
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_b4ff899f_d48e_4095_937d_c83b187e1152
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:79717
name: PPCS
is: Q9HAB8
initial amount: NaN
type: Species

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR MI34PP
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110009#
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.1.3.66
fast: false
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: false
name: inositol-3,4-bisphosphate 4-phosphatase
notes: GENE_ASSOCIATION: (3631.2) or (3631.1) or (8821.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:7608176,PMID:9295334 NOTES:NCD

metaR r0475
is: SBO:0000176
kinetic law: MODEL1310110009#
fast: false
product: MODEL1310110009#
is described by: ECO:0000000
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reversible: true
reactant: MODEL1310110009#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_3041a383_3ad3_47fe_a9e7_7d2f6c3ef31d
boundary condition: true
has only substance units: false
constant: false
is: P51160
name: PDE6C
initial amount: NaN
is encoded by: hsa:5146
initial concentration: NaN
is: SBO:0000252
type: Species

metaM fum c
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00134
type: Species
name: Fumarate
is: CHEBI:29806
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
initial concentration: 1.0
is: C00122
has only substance units: false

metaR MECOALm
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.2.1.5
fast: false
product: MODEL1310110009#
modifier: MODEL1310110009#
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
is described by: ECO:0000212
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176
kinetic law: MODEL1310110009#

metaR CAATPS
reversible: false
modifier: MODEL1310110009#
type: Reaction
is: SBO:0000185
name: Ca ATPase
fast: false
product: MODEL1310110009#
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.6.3.8
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_fc8689a2_1df4_49de_a33f_d6b9bb8dba44
name: PDE4B
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5142
is: Q5TEK5
type: Species
is: SBO:0000252
constant: false
initial amount: NaN

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_29444b66_eb98_4c73_ba44_575701c2bdce
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
name: ME2
has only substance units: false
constant: false
is: P23368
is encoded by: hsa:4200

metaM ksi l
is: CHEBI:57455
name: keratan sulfate I
constant: false
is: SBO:0000247
is: C00445
has only substance units: false
initial concentration: 1.0
is: HMDB01354
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
type: Species
initial amount: NaN
boundary condition: false

metaR XYLTt
name: Xylitol transport via passive diffusion
type: Reaction
kinetic law: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
reactant: MODEL1310110009#
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110009#_b562d0db_ee27_4dd1_a88f_44bf5c0c37b1
constant: false
type: Species
has only substance units: false
is encoded by: hsa:1593
is: SBO:0000252
boundary condition: true
name: CYP27A1
initial amount: NaN
is: Q02318
initial concentration: NaN

metaM arachd r
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: arachidonate
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
type: Species
is: CHEBI:32395
is: HMDB01043
boundary condition: false
constant: false
initial concentration: 1.0

metaR LPS2
is: SBO:0000176
kinetic law: MODEL1310110009#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
reactant: MODEL1310110009#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.1.34
name: lipase
type: Reaction
product: MODEL1310110009#
modifier: MODEL1310110009#

metaR PPDOx
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD
fast: false
type: Reaction
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
reactant: MODEL1310110009#
name: Propane-1,2-diol:NAD+ 1-oxidoreductase

metaR VLCS2r
kinetic law: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
reactant: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
name: Very-long-chain-fatty-acid-CoA ligase
reversible: false
is described by: ECO:0000304
modifier: MODEL1310110009#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_e6228b2c_f2c7_45f8_89b5_53634e325729
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: Q4J699
boundary condition: true
is: SBO:0000252
is encoded by: hsa:491
initial amount: NaN
name: ATP2B2

metaR PPDOy
reactant: MODEL1310110009#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110009#
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.21
reversible: false
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
kinetic law: MODEL1310110009#
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
type: Reaction
is: SBO:0000176

metaR G14T16g
reactant: MODEL1310110009#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
fast: false
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38

http://identifiers.org/biomodels.db/MODEL1310110009#_f8533f5a_81e1_47ae_8fd3_e333cd0bd860
initial amount: NaN
is encoded by: hsa:124454
type: Species
has only substance units: false
boundary condition: true
constant: false
is: Q5JPH6
initial concentration: NaN
is: SBO:0000252
name: EARS2

metaM HC01501 c
is: SBO:0000247
has only substance units: false
type: Species
name: hydroxidodioxidosulfidosulfate(1-)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: HO3S2 CHARGE: -1 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-1 EHMN_ABBREVIATION: C05529
constant: false
initial amount: NaN
is: CHEBI:33539

metaR EX adn LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Adenosine
type: Reaction

metaR r0360
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
type: Reaction
product: MODEL1310110009#
fast: false
is: SBO:0000176
reactant: MODEL1310110009#
reversible: false
modifier: MODEL1310110009#
is described by: ECO:0000000
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/6.2.1.16
name: Glycolysis / Glyconeogenesis EC:2.7.1.1

http://identifiers.org/biomodels.db/MODEL1310110009#_d79db255_7efc_48fb_957c_6dc18260c8e2
initial amount: NaN
is encoded by: hsa:27068
has only substance units: false
constant: false
type: Species
boundary condition: true
name: PPA2
is: SBO:0000252
is: F8WDN9
initial concentration: NaN

metaM 35cgmp n
has only substance units: false
initial concentration: 1.0
name: 3',5'-cyclic GMP(1-)
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
is: CHEBI:57746
constant: false
boundary condition: false
is: HMDB01314

http://identifiers.org/biomodels.db/MODEL1310110009#_44cc6a4f_eb1d_472e_bf0f_8a13e0b45df2
is encoded by: hsa:54
name: ACP5
type: Species
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is: P13686
initial amount: NaN
initial concentration: NaN

metaM sph1p e
initial amount: NaN
has only substance units: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
is: HMDB01383
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:57939
constant: false
is: SBO:0000247
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate

metaM icit x
name: isocitrate(3-)
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:16087
is: HMDB00193
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311

metaM c3dc e
name: malonyl carnitine
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB02095
notes: FORMULA: C10H16NO6 CHARGE: -1
has only substance units: false
initial concentration: 1.0
constant: false
type: Species

metaR ICDHyrm
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.42
product: MODEL1310110009#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110009#
name: Isocitrate dehydrogenase (NADP+)
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
kinetic law: MODEL1310110009#
type: Reaction

metaR r0474
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110009#_b2e340cd_3aa0_4f6c_8aa8_1ee3b3f8d1b4
is: SBO:0000252
is encoded by: hsa:728441
has only substance units: false
initial concentration: NaN
constant: false
name: GGT2
boundary condition: true
initial amount: NaN
type: Species

metaR EX glyb LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycine betaine exchange
type: Reaction

metaM udpacgal l
is: SBO:0000247
is: CHEBI:57847
is: HMDB00304
name: UDP-N-acetyl-D-galactosamine(2-)
has only substance units: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_f7d59150_5705_439f_baa2_840d5f2f72c2
boundary condition: true
has only substance units: false
name: _100287639_1_c
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:100287639
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_d0ac1176_1da2_470b_b2ed_01307be38b4b
boundary condition: true
name: GBA
initial amount: NaN
is: SBO:0000252
is: B7Z6S9
is encoded by: hsa:2629
constant: false
initial concentration: NaN
type: Species
has only substance units: false

metaR MI1P Dtn
is: SBO:0000185
name: inositol 1-phosphate nuclear transport (diffusion)
reversible: true
fast: false
kinetic law: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110009#
type: Reaction
is described by: ECO:0000000

metaM HC02206 c
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
name: prostaglandin C1(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
constant: false
is: CHEBI:57399
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_e55903e6_e6ae_41f3_870d_76149aec516e
initial concentration: NaN
has only substance units: false
name: SLC9A3
is: P48764
initial amount: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:6550
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_8d750db1_c3a7_4357_9e26_0a0ee40b2d2a
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:56953
type: Species
initial amount: NaN
is: Q9NPB1
constant: false
boundary condition: true
name: NT5M

metaR SARDHm
reversible: false
type: Reaction
name: Sarcosine dehydrogenase (m)
is: SBO:0000176
product: MODEL1310110009#
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
is version of: http://identifiers.org/ec-code/1.5.99.1

metaM datp n
is: CHEBI:61404
initial amount: NaN
is: SBO:0000247
type: Species
name: dATP
constant: false
has only substance units: false
boundary condition: false
is: C00131
is: HMDB01532
initial concentration: 1.0
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131

metaR r1931
product: MODEL1310110009#
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110009#
name: Y+LAT2 Utilized transport
fast: false

metaR FAS80COA L
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
reversible: false
type: Reaction
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
is: SBO:0000176
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reactant: MODEL1310110009#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.85

metaM ksi pre10 g
constant: false
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 10
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
is: C00130
boundary condition: false
is: HMDB00175
initial concentration: 1.0
is: CHEBI:58053

metaR SERDGLNexR
reversible: true
product: MODEL1310110009#
is: SBO:0000185
kinetic law: MODEL1310110009#
is described by: ECO:0000304
modifier: MODEL1310110009#
name: D-Serine/Glutamine reversible exchange
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
type: Reaction

metaR PPA
name: inorganic diphosphatase
fast: false
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110009#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
product: MODEL1310110009#
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.6.1.1
modifier: MODEL1310110009#

metaR FAOXC15ATPx
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C15)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_00dde6ae_d524_435c_884b_2beef98e7a0d
is: SBO:0000252
is: Q8TCD5
type: Species
is encoded by: hsa:30833
boundary condition: true
has only substance units: false
name: NT5C
initial amount: NaN
initial concentration: NaN
constant: false

metaM leuktrE4 e
initial concentration: 1.0
initial amount: NaN
constant: false
name: leukotriene E4(1-)
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:57462
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
has only substance units: false
is: HMDB02200

metaR r0472
product: MODEL1310110009#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reactant: MODEL1310110009#
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reversible: true
is: SBO:0000176

metaM icit m
type: Species
boundary condition: false
is: HMDB00193
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: Isocitrate
constant: false
is: C00311
has only substance units: false
is: CHEBI:16087
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaR IDOURte
reversible: true
is: SBO:0000185
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110009#
product: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
name: L-iduronate transport, extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110009#_3f1528d3_0f92_48d5_a221_8a4aadaaaa8e
initial concentration: NaN
name: SLC16A8
constant: false
boundary condition: true
is encoded by: hsa:23539
has only substance units: false
is: O95907
initial amount: NaN
type: Species
is: SBO:0000252

metaR r1930
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110009#
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110009#
reversible: false
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110009#_31f8d60d_15c5_4c03_94b8_7b24b9b987b6
initial amount: NaN
boundary condition: true
has only substance units: false
is: B3KUK6
name: NT5C1B
is encoded by: hsa:93034
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_b8c6501b_ab6b_4bde_8d06_2c2c08b345d1
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:84264
type: Species
name: HAGHL
is: SBO:0000252
initial amount: NaN
is: Q6PII5

metaM HC02206 e
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
is: CHEBI:57399
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
initial amount: NaN
name: prostaglandin C1(1-)
is: SBO:0000247

metaR r1400
fast: false
name: Active transport
is: SBO:0000185
reversible: false
is described by: ECO:0000000
product: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#

metaR ALADGLNexR
type: Reaction
name: L-alanine/glutamine reversible exchange
reversible: true
reactant: MODEL1310110009#
is described by: ECO:0000304
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110009#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110009#

metaM hexde7coa x
initial amount: NaN
is: SBO:0000247
type: Species
name: 7-hexadecenoylcoa
has only substance units: false
constant: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
is: HMDB02288

http://identifiers.org/biomodels.db/MODEL1310110009#_1b8ef07a_9767_4d88_88b2_d40d9f2697d2
is encoded by: hsa:10476
has only substance units: false
initial concentration: NaN
name: ATP5H
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
is: O75947
boundary condition: true

metaR TIGCRNe
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tiglyl carnitine into the extra cellular fluid
type: Reaction

metaR ADPT
fast: false
reversible: false
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (353.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.7 Confidence Level: 4 AUTHORS: PMID:14674717,PMID:15196008 NOTES:
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.7
name: adenine phosphoribosyltransferase
type: Reaction

metaM 2hb e
boundary condition: false
is: SBO:0000247
is: CHEBI:1148
name: 2-Hydroxybutyrate
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
initial concentration: 1.0
constant: false
is: HMDB00008
initial amount: NaN
type: Species
has only substance units: false

metaR B3GNT39g
is: SBO:0000176
reversible: false
reactant: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000000
fast: false
type: Reaction
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
product: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110009#_0252da8b_dcd1_4101_97b4_988f683ffe2b
is: Q9Y217
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: MTMR6
is encoded by: hsa:9107
initial amount: NaN

metaR DGK2m
name: deoxyguanylate kinase (dGMP:dATP) (mitochondrial)
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.8 Confidence Level: 2 AUTHORS: NOTES:Added EC- JLR IT
reactant: MODEL1310110009#
product: MODEL1310110009#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_b2c0e14e_0081_44f7_9143_de2215aeefd0
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:U37519
is: SBO:0000252
name: _U37519_1_c
has only substance units: false
initial amount: NaN
type: Species

metaR PALFATPtc
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_a04d5931_87d7_4820_b70b_40838ba2d758
constant: false
has only substance units: false
is encoded by: hsa:1327
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: COX4I1
boundary condition: true
is: P13073

metaR FUCASE2e
reversible: false
kinetic law: MODEL1310110009#
product: MODEL1310110009#
modifier: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:10460218,PMID:11389735,PMID:12604617,PMID:2317201 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
fast: false
name: alpha-fucosidase, extracellular
is version of: http://identifiers.org/ec-code/3.2.1.51
type: Reaction

metaM mi1345p c
boundary condition: false
is: HMDB01059
is: CHEBI:57895
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
is: SBO:0000247
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272

metaM nmn c
is: CHEBI:14649
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: C00455
boundary condition: false
type: Species
constant: false
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
is: HMDB00229
name: NMN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_be17d14c_6256_460c_9e87_b4477dd51f97
type: Species
name: AADAT
is: Q4W5N8
has only substance units: false
constant: false
is encoded by: hsa:51166
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR FUCASE2ly
name: alpha-fucosidase, lysosomal
type: Reaction
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110009#
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.51
reactant: MODEL1310110009#
modifier: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_97093cdd_2d10_4497_aab4_51a13a896201
name: ACAD10
type: Species
is encoded by: hsa:80724
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is: G3XAJ0

metaR RTOTALt
product: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000185
name: RTOTAL transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110009#

metaM leuktrE4 c
initial concentration: 1.0
is: HMDB02200
initial amount: NaN
constant: false
boundary condition: false
type: Species
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
has only substance units: false
is: CHEBI:57462
is: SBO:0000247
name: leukotriene E4(1-)

metaR r0470
is: SBO:0000176
fast: false
reactant: MODEL1310110009#
is described by: ECO:0000000
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reversible: true
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_ba5fba87_7fdf_476b_b1b3_cbdf2df9d600
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:9091
name: PIGQ
is: B2RAU6
initial concentration: NaN
type: Species
is: SBO:0000252

metaR r0365
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.3.1.72
type: Reaction
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
fast: false
is: SBO:0000176
product: MODEL1310110009#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59

metaM 3docopencoa x
initial amount: NaN
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
name: 3,7,10,13,16-docosapentenoylcoa
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_6ba8f98c_101f_4707_9461_a007d116745a
is encoded by: hsa:8527
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q16760
constant: false
initial amount: NaN
name: DGKD

metaM ksi deg4 l
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: HMDB00868
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: keratan sulfate I, degradation product 4
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
is: CHEBI:57737

metaM arachd x
is: SBO:0000247
initial concentration: 1.0
name: arachidonate
type: Species
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: CHEBI:32395
boundary condition: false
constant: false
is: HMDB01043
initial amount: NaN

metaM mi134p c
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:58414
has only substance units: false
type: Species
is: HMDB01143

metaM 2hb c
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:1148
name: 2-Hydroxybutyrate
is: HMDB00008
has only substance units: false
constant: false
boundary condition: false

metaM dpcoa c
initial concentration: 1.0
boundary condition: false
is: HMDB01373
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: CHEBI:57328
has only substance units: false
is: C00882
type: Species
is: SBO:0000247
initial amount: NaN
name: Dephospho-CoA
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_31c27be8_047d_4bb4_aac5_d0b38b787f95
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:6487
name: ST3GAL3
initial concentration: NaN

metaM sphs1p c
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
name: sphingosine 1-phosphate(1-)
is: HMDB00277
is: SBO:0000247
boundary condition: false
is: CHEBI:60119
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_abe2454a_cea4_45f8_8d3b_c330e302fe9e
is encoded by: hsa:R33828
type: Species
has only substance units: false
name: _R33828_1_c
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false

metaM pail5p hs n
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
type: Species
boundary condition: false
constant: false
is: CHEBI:57795
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR DM dsT antigen g
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dsT antigen(g)
type: Reaction

metaM 35cgmp c
is: CHEBI:57746
initial amount: NaN
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
type: Species
name: 3',5'-cyclic GMP(1-)
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB01314
boundary condition: false

metaR HSD3A1r
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is version of: http://identifiers.org/ec-code/1.1.1.225
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110009#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_e7f53553_12ee_4f65_973e_9364561c433c
is encoded by: hsa:7360
is: SBO:0000252
has only substance units: false
name: UGP2
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
constant: false

metaR RE2660C
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
product: MODEL1310110009#
reversible: true
kinetic law: MODEL1310110009#
is described by: ECO:0000000
fast: false
name: RE2660
is: SBO:0000176
reactant: MODEL1310110009#

metaM 2docohexecoa m
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: 2,7,10,13,16,19-docosahexenoylcoa
type: Species
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN
has only substance units: false

metaM em2emgacpail prot hs r
has only substance units: false
is: C00213
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2X CHARGE: 0
is: HMDB00271
initial concentration: 1.0
type: Species
is: CHEBI:3513
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_ce99df7f_7a6a_4410_b835_07184e843223
is: Q59HH3
has only substance units: false
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:2618
is: SBO:0000252
name: GART

http://identifiers.org/biomodels.db/MODEL1310110009#_66c656d6_889a_4115_acaa_f1195dc0f43a
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: D3DWC4
initial amount: NaN
type: Species
constant: false
name: SGMS1
is encoded by: hsa:259230
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_13798e37_d865_4978_af56_daaf1f46777d
type: Species
is: O75355
boundary condition: true
has only substance units: false
name: ENTPD3
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:956

metaM m6masnB2 g
constant: false
notes: FORMULA: C58H97N2O45X CHARGE: 0
is: HMDB01356
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:57312

metaR CERT2gt
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110009#
is described by: ECO:0000000
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
type: Reaction
reversible: true
kinetic law: MODEL1310110009#
name: ceramide transport protein
is: SBO:0000185
fast: false
reactant: MODEL1310110009#

metaR NH4tp
is described by: ECO:0000000
kinetic law: MODEL1310110009#
name: ammonia peroxisomal transport
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110009#
reversible: true
fast: false
reactant: MODEL1310110009#

metaM sphs1p e
type: Species
is: HMDB00277
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:60119
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
constant: false
has only substance units: false
boundary condition: false
name: sphingosine 1-phosphate(1-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_054cd235_f03e_4e12_a078_88e9fa653c24
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: SHMT2
is encoded by: hsa:6472
is: SBO:0000252
initial concentration: NaN
is: B4DJQ3
boundary condition: true

metaR GULN3D
fast: false
reactant: MODEL1310110009#
type: Reaction
is: SBO:0000176
name: L-gulonate 3-dehydrogenase
reversible: true
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
kinetic law: MODEL1310110009#
is described by: ECO:0000000

metaR GGH 10FTHF7GLUe
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110009#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110009#
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
reactant: MODEL1310110009#
modifier: MODEL1310110009#

metaR UGALGTg
notes: GENE_ASSOCIATION: (3906.1) and (2683.1) or (8704.2) or (8704.1) SUBSYSTEM: Galactose metabolism EC Number: 2.4.1.22 Confidence Level: 4 AUTHORS: PMID:11419947 NOTES:NCD
name: UDPgalactose:D-glucose 4-beta-D-galactosyltransferase, Golgi apparatus
is: SBO:0000176
reversible: false
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
product: MODEL1310110009#
is described by: ECO:0000134

metaR TETDECE1CRNe
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tetradecenoyl carnitine into extra cellular space
type: Reaction

metaR MM7B2g
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.113
is described by: ECO:0000000
reactant: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
modifier: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000176
reversible: false
fast: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110009#_5ad8c483_611c_488d_a8be_4c1ee9605e69
has only substance units: false
boundary condition: true
name: VNN3
is: SBO:0000252
is encoded by: hsa:55350
initial concentration: NaN
type: Species
constant: false
initial amount: NaN

metaM 4hoxpacd c
initial amount: NaN
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
is: SBO:0000247
type: Species
boundary condition: false
name: (4-hydroxyphenyl)acetaldehyde
is: HMDB03767
has only substance units: false
is: CHEBI:15621
initial concentration: 1.0
constant: false

metaM fum m
name: Fumarate
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: C00122
is: CHEBI:29806
is: SBO:0000247
type: Species
is: HMDB00134
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_9f0f1265_7c3a_401c_a686_97fdbf289426
initial concentration: NaN
initial amount: NaN
type: Species
is: O75414
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:10201
name: NME6

metaM 3sala c
name: 3-Sulfino-L-alanine
is: C00606
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:61085
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606

metaR S6T16g
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110009#
fast: false
is: SBO:0000176
modifier: MODEL1310110009#
reactant: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
is described by: ECO:0000000

metaM utp m
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00285
boundary condition: false
name: UTP(4-)
is: CHEBI:46398
type: Species
initial amount: NaN
is: SBO:0000247

metaM akg x
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
type: Species
has only substance units: false
name: 2-oxoglutarate(2-)
initial concentration: 1.0
is: CHEBI:16810
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00208

metaR FAOXC5C5OHm
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C5OH)m
type: Reaction

metaM guln c
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
initial amount: NaN
is: HMDB03290
boundary condition: false
is: CHEBI:13115
name: L-gulonate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_a9001f61_14e2_430b_afb6_a9c6265f4e97
name: COX5A
is: P20674
initial amount: NaN
is encoded by: hsa:9377
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

metaM 6a2ohxnt x
type: Species
boundary condition: false
constant: false
name: 6-amino-2-oxohexanoic acid
is: HMDB12151
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
is: SBO:0000247
is: CHEBI:17534
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM cysam c
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
is: HMDB02991
has only substance units: false
is: CHEBI:58029
boundary condition: false
is: SBO:0000247
name: cysteaminium
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false

metaR RE3566C
name: RE3566
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is: SBO:0000176
fast: false
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
reversible: true

metaR N3Tg
fast: false
is: SBO:0000176
kinetic law: MODEL1310110009#
reversible: false
modifier: MODEL1310110009#
reactant: MODEL1310110009#
product: MODEL1310110009#
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.122
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_b389ef1c_9ef9_4a7b_8bad_afe6afc204a5
is: P35754
is: SBO:0000252
name: GLRX
boundary condition: true
type: Species
is encoded by: hsa:2745
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_d8603653_9674_4618_a246_2aad6b1968b1
constant: false
initial amount: NaN
name: CHST6
is encoded by: hsa:4166
is: Q9GZX3
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN

metaR EX dhdascb LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dehydroascorbide(1-)
type: Reaction

metaM utp n
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00285
boundary condition: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
constant: false
name: UTP(4-)
is: CHEBI:46398
has only substance units: false

metaM arachcoa m
initial amount: NaN
is: CHEBI:15527
type: Species
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: HMDB04258
constant: false
has only substance units: false
boundary condition: false
name: arachidyl coenzyme A
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_7639ef24_81ef_4564_beaf_c7fbbcbb5c02
name: MAN1A2
constant: false
is encoded by: hsa:10905
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is: O60476

http://identifiers.org/biomodels.db/MODEL1310110009#_9ca52453_dc22_4e4e_b86b_4fa88bcd5abd
name: PDE4A
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5141
is: P27815
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
constant: false

metaR ALCD21 D
name: alcohol dehydrogenase (D-1,2-propanediol)
fast: false
is: SBO:0000176
product: MODEL1310110009#
modifier: MODEL1310110009#
reversible: false
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.99.24
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.1

metaR BACCL
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
fast: false
type: Reaction
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/6.3.4.10
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000269
modifier: MODEL1310110009#
name: biotin-[acetyl-CoA-carboxylase] ligase
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110009#_5a79997d_6dd8_41f0_91c4_7ae4dede29f0
boundary condition: true
is: SBO:0000252
name: OGDH
constant: false
has only substance units: false
is: Q02218
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:4967

metaM arachcoa c
initial concentration: 1.0
name: arachidyl coenzyme A
is: HMDB04258
boundary condition: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:15527
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_68adfe91_1db3_4bc0_9de7_ac381b1fadf8
initial amount: NaN
name: _728637_1_c
is encoded by: hsa:728637
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR r2200
reactant: MODEL1310110009#
is described by: ECO:0000000
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true
kinetic law: MODEL1310110009#
is: SBO:0000185
product: MODEL1310110009#
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r0149
kinetic law: MODEL1310110009#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.39
product: MODEL1310110009#

metaM ksii core2 pre2 g
is: C00130
type: Species
boundary condition: false
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 2
is: CHEBI:58053
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C39H63N3O28X CHARGE: -1
is: SBO:0000247
constant: false

metaR FAOXC181C161x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C18:1-->C16:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_371d09db_89bf_4849_b046_a70db9e4d19c
constant: false
type: Species
is: SBO:0000252
name: _AI761708_1_m
initial amount: NaN
is encoded by: hsa:AI761708
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM fald m
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: formaldehyde
is: CHEBI:16842
has only substance units: false
type: Species
is: HMDB01426
constant: false

metaR AG13T8g
reversible: false
fast: false
kinetic law: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
modifier: MODEL1310110009#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110009#_eea5ce5d_c529_4569_a79f_e456de8952e1
initial amount: NaN
is: Q86XP1
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: DGKH
has only substance units: false
is encoded by: hsa:160851

metaM CE4872 c
has only substance units: false
initial concentration: 1.0
is: CHEBI:15748
boundary condition: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
is: HMDB00127

http://identifiers.org/biomodels.db/MODEL1310110009#_9d452c89_7f87_4150_a53a_e0d7e9e69b83
is: Q9UGH3
constant: false
initial concentration: NaN
name: SLC23A2
is encoded by: hsa:9962
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_2974ec2c_3e40_4e99_a19f_e173c6aa2da2
type: Species
constant: false
name: DGKI
is: SBO:0000252
is encoded by: hsa:9162
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: O75912
boundary condition: true

metaR r2079
modifier: MODEL1310110009#
reversible: true
is described by: ECO:0000000
product: MODEL1310110009#
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110009#
is: SBO:0000185
kinetic law: MODEL1310110009#

metaR RE2660N
product: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: true
is: SBO:0000176
modifier: MODEL1310110009#
name: RE2660
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.96
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_b6af76be_6dee_402b_9376_4f1ad27a7dc9
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6487
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
name: ST3GAL3

metaM dadp n
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB01508
name: dADP(3-)
is: CHEBI:57667
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false

metaR GUACYC
fast: false
notes: GENE_ASSOCIATION: (2977.1 and 2983.1) or (4882.2) or (2982.1 and 2974.1) or (2986.1) or (4882.1) or (2984.1) or (4881.1) or (2977.1 and 2974.1) or (3000.1) or (2982.1 and 2983.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.2 Confidence Level: 4 AUTHORS: PMID:10449911,PMID:10777682,PMID:11565546,PMID:11851379,PMID:1352257,PMID:14748740,PMID:15371450,PMID:7601467,PMID:7761400,PMID:7777544,PMID:7954658,PMID:8838319,PMID:9097965,PMID:9742212 NOTES:IT
product: MODEL1310110009#
reactant: MODEL1310110009#
modifier: MODEL1310110009#
reversible: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.6.1.2
kinetic law: MODEL1310110009#
name: guanylate cyclase

http://identifiers.org/biomodels.db/MODEL1310110009#_127b2dca_81fc_4d17_9f6c_062ca303cb71
is: Q08828
is: SBO:0000252
name: ADCY1
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:107
type: Species

metaR S2TASE1ly
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.13
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
name: iduronate-2-sulfatase, lysosomal
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110009#_d2806b63_6000_4e78_8836_19dd98a8ff63
constant: false
initial concentration: NaN
is encoded by: hsa:6575
has only substance units: false
is: B2RBR4
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
name: SLC20A2

metaR KHte
is: SBO:0000185
kinetic law: MODEL1310110009#
reversible: true
is described by: ECO:0000134
type: Reaction
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
name: KHte
reactant: MODEL1310110009#

metaR r2202
modifier: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110009#

metaR MHISOR
reversible: false
fast: false
modifier: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.21
name: N-Methylhistamine:oxygen oxidoreductase (deaminating)
is: SBO:0000176
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Histidine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:12072962,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.4.3.22
kinetic law: MODEL1310110009#
is described by: ECO:0000269

metaR CYTK14
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110009#
is: SBO:0000176
name: cytidylate kinase (dCMP,UTP)
kinetic law: MODEL1310110009#
product: MODEL1310110009#
fast: false
type: Reaction
reactant: MODEL1310110009#

metaM HC01401 x
is: CHEBI:27668
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
name: (S)-3-Hydroxydodecanoyl-CoA
boundary condition: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
initial amount: NaN
has only substance units: false

metaM ksi deg15 l
is: CHEBI:12936
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
has only substance units: false
boundary condition: false
is: SBO:0000247
name: keratan sulfate I, degradation product 15
initial amount: NaN
is: HMDB00143

metaM 3ivcoa m
is: http://identifiers.org/pubchem.compound/11966188
boundary condition: false
initial amount: NaN
constant: false
type: Species
name: 3-hydroxyisovalerylcoa
initial concentration: 1.0
has only substance units: false
is: HMDB06870
is: C05998
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
is: SBO:0000247

metaM dadp m
constant: false
name: dADP(3-)
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB01508
initial concentration: 1.0
boundary condition: false
is: CHEBI:57667
initial amount: NaN

metaM icit c
is: HMDB00193
is: C00311
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:16087
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
name: Isocitrate
has only substance units: false
initial concentration: 1.0
constant: false

metaR r2201
is described by: ECO:0000000
modifier: MODEL1310110009#
type: Reaction
reversible: true
product: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reactant: MODEL1310110009#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110009#_1de7fdcd_6708_45fc_9b75_bf9795a795d8
is encoded by: hsa:6569
has only substance units: false
initial amount: NaN
type: Species
name: SLC34A1
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q7Z725
boundary condition: true

metaR METS
is: SBO:0000176
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (4548.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.1.1.13 Confidence Level: 4 AUTHORS: PMID:8968736,PMID:9013615 NOTES:Human Y/N: Y
type: Reaction
reversible: false
name: methionine synthase
reactant: MODEL1310110009#
is described by: ECO:0000134
product: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.1.1.13

metaR GGH 7DHFl
kinetic law: MODEL1310110009#
name: Gamma-glutamyl hydrolase (7DHF), lysosomal
modifier: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110009#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
product: MODEL1310110009#
is described by: ECO:0000000

metaR SAMHISTA
type: Reaction
reversible: false
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.1.1.8
product: MODEL1310110009#
name: S-Adenosyl-L-methionine:histamine N-tele-methyltransferase
is described by: ECO:0000269
kinetic law: MODEL1310110009#
fast: false
is: SBO:0000176
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (3176.1) SUBSYSTEM: Histidine metabolism EC Number: 2.1.1.8 Confidence Level: 4 AUTHORS: PMID:7943261 NOTES:SAB R02155

metaR RE1807C
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reversible: true
name: RE1807
type: Reaction
fast: false
reactant: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_47eacaad_2bb5_4d21_bb96_ecac7defa369
initial amount: NaN
name: _22305_2_c
is encoded by: hsa:22305
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
constant: false

metaR CYTK13
is described by: ECO:0000269
kinetic law: MODEL1310110009#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
product: MODEL1310110009#
reactant: MODEL1310110009#
name: cytidylate kinase (dCMP,dATP)
modifier: MODEL1310110009#

metaM dpcoa e
is: CHEBI:57328
is: C00882
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB01373
type: Species
boundary condition: false
name: Dephospho-CoA
constant: false
is: SBO:0000247
notes: FORMULA: C21H33N7O13P2S CHARGE: -2

metaR ADMDC
name: adenosylmethionine decarboxylase
is: SBO:0000176
modifier: MODEL1310110009#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.1.1.50
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (262.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.50 Confidence Level: 4 AUTHORS: PMID:2460457 NOTES:
reactant: MODEL1310110009#
product: MODEL1310110009#
kinetic law: MODEL1310110009#

metaM hpdca e
initial amount: NaN
boundary condition: false
is: HMDB02259
has only substance units: false
initial concentration: 1.0
name: margarate
type: Species
is: SBO:0000247
is: CHEBI:32366
constant: false
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

metaM dopasf c
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
name: dopamine 3-O-sulfate
is: CHEBI:37946
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
is: HMDB06275
type: Species
initial amount: NaN
has only substance units: false

metaM no c
is: SBO:0000247
has only substance units: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: CHEBI:16480
is: HMDB03378
constant: false
name: Nitric oxide
type: Species
is: C00533
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR GACPAILter
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110009#
name: glucosaminyl-acylphosphatidylinositol ER flippase
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
product: MODEL1310110009#
reactant: MODEL1310110009#

metaR r1627
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_ac8ac376_4fb7_49cb_8f87_dd1fd4881ada
initial amount: NaN
is: Q53YE7
type: Species
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4128
name: MAOA

http://identifiers.org/biomodels.db/MODEL1310110009#_e9b60544_b14a_4114_99e7_2ac08c965ddf
is: SBO:0000252
is: O00462
constant: false
has only substance units: false
initial amount: NaN
name: MANBA
is encoded by: hsa:4126
initial concentration: NaN
type: Species
boundary condition: true

metaR THYMt
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
is: SBO:0000185
name: thymine reversible transport via facilated diffusion
fast: false
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
modifier: MODEL1310110009#

metaM mercplaccys c
is: HMDB06512
type: Species
name: 3-mercaptolactate-cysteine disulfide
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM utp c
initial amount: NaN
is: C00075
is: HMDB00285
name: UTP
boundary condition: false
is: CHEBI:46398
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
constant: false

metaR DATPtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID: 16816105, PMID: 17403938. NOTES:
reversible: false
fast: false
kinetic law: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
is: SBO:0000185
name: transport of dATP into mitochondria
is described by: ECO:0000134

metaM retinal cis 13 c
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: CHEBI:45487
constant: false
is: HMDB06220
type: Species
name: 13-cis-retinal
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_a05355a6_64ab_479c_94cf_4f8ab3160488
has only substance units: false
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: P15531
is encoded by: hsa:4830
boundary condition: true
name: NME1
is: SBO:0000252

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaR EX 1glyc hs LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1 acyl phosphoglycerol exchange
type: Reaction

metaR GTHPm
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
is described by: ECO:0000269
type: Reaction
name: glutathione peroxidase, mitochondria
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.11.1.12
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.11.1.15
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
modifier: MODEL1310110009#
reversible: true

metaR P5CDm
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
fast: false
kinetic law: MODEL1310110009#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.5.1.12
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000269
product: MODEL1310110009#
reversible: false

metaR r1628
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110009#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM sphings c
boundary condition: false
type: Species
is: CHEBI:57756
is: HMDB00252
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
name: sphingosine(1+)

metaM retinol 9 cis c
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
is: HMDB06217
boundary condition: false
is: CHEBI:17336
has only substance units: false
name: 9-cis-retinol

http://identifiers.org/biomodels.db/MODEL1310110009#_2502054c_378b_4be2_b9e7_bebc3a70b0e8
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6799
name: SULT1A2
has only substance units: false
type: Species
constant: false

metaM HC01610 e
constant: false
is: CHEBI:28607
name: CoproporphyrinogenI
initial concentration: 1.0
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR r1629
is: SBO:0000185
product: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaM btn m
type: Species
boundary condition: false
constant: false
is: CHEBI:57586
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
name: biotinate
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB00030

metaM c4crn x
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB02013
name: butyryl carnitine
is: C02862
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C11H21NO4 CHARGE: 0
is: http://identifiers.org/pubchem.compound/213144

metaR UDPGLCAter
type: Reaction
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: true
is described by: ECO:0000269
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
fast: false
modifier: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
product: MODEL1310110009#

metaM dopasf e
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:37946
boundary condition: false
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
name: dopamine 3-O-sulfate
is: HMDB06275
type: Species
initial amount: NaN
is: SBO:0000247

metaR FAOXC1811603m
name: Beta oxidation fatty acid
kinetic law: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110009#
is described by: ECO:0000269
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110009#
is: SBO:0000176

metaR MI134PP
name: inositol-1,3,4-trisphosphate 1-phosphatase
fast: false
type: Reaction
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: false
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.57
is: SBO:0000176
product: MODEL1310110009#
is described by: ECO:0000269

metaM datp m
type: Species
constant: false
name: dATP
is: HMDB01532
initial concentration: 1.0
has only substance units: false
is: CHEBI:61404
boundary condition: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: SBO:0000247
initial amount: NaN
is: C00131

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaR DIDPtn
name: dIDP nuclear transport
is described by: ECO:0000000
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
reactant: MODEL1310110009#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110009#
type: Reaction

metaM no e
is: C00533
type: Species
name: Nitric oxide
is: SBO:0000247
boundary condition: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
initial amount: NaN
is: CHEBI:16480
is: HMDB03378
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_b57e4404_4bcd_476a_8a0c_3a83f1eafd6a
is encoded by: hsa:23533
has only substance units: false
initial concentration: NaN
type: Species
has part: Q8WYR1
constant: false
is: SBO:0000297
boundary condition: true
name: PIK3R5:PIK3CG
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_38440aa1_762d_4573_9a0e_3500dcf2ca77
constant: false
initial amount: NaN
is: SBO:0000252
name: ZADH2
has only substance units: false
is: Q8N4Q0
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:284273

http://identifiers.org/biomodels.db/MODEL1310110009#_306363c8_1525_45c9_a231_18139e52e1bf
is encoded by: hsa:5295
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false
name: PIK3R1
is: P27986

metaM utp e
boundary condition: false
constant: false
is: CHEBI:46398
has only substance units: false
is: HMDB00285
initial concentration: 1.0
name: UTP(4-)
is: SBO:0000247
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
type: Species
initial amount: NaN

metaM c226coa c
is: http://identifiers.org/pubchem.compound/47205479
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
type: Species
boundary condition: false
has only substance units: false
is: C16169
constant: false
name: cervonyl coenzyme A
initial amount: NaN

metaM mercplaccys e
constant: false
name: 3-mercaptolactate-cysteine disulfide
type: Species
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB06512
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_8cb7072f_0010_4a2d_a170_c19f031a4f08
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:3028
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q99714
name: HSD17B10
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_fe4fd0d0_b9f1_4fc1_b8db_83de5e0eeadb
constant: false
has only substance units: false
is encoded by: hsa:4709
is: SBO:0000252
initial concentration: NaN
is: Q6IB80
type: Species
boundary condition: true
name: NDUFB3
initial amount: NaN

metaM arachd c
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
initial concentration: 1.0
name: arachidonate
is: SBO:0000247
is: HMDB01043
initial amount: NaN
is: CHEBI:32395
has only substance units: false
boundary condition: false
type: Species
constant: false

metaM retinol 9 cis e
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
initial concentration: 1.0
name: 9-cis-retinol
type: Species
is: HMDB06217
is: CHEBI:17336
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false

metaR FACOAL181i
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
name: C181 fatty acid activation
kinetic law: MODEL1310110009#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
reactant: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
reversible: false
modifier: MODEL1310110009#
fast: false

metaR r2353
is: SBO:0000185
product: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
fast: false
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110009#

metaM dadp c
name: dADP
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:57667
has only substance units: false
constant: false
is: HMDB01508
type: Species
is: C00206
boundary condition: false

metaR LPCOXp
product: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
name: L-pipecolate oxidase, peroxisomal
reactant: MODEL1310110009#
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.3.1
fast: false

metaR DRIBt
is described by: ECO:0000000
reversible: true
fast: false
name: deoxyribose transport via diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
product: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#

metaR r1623
reactant: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
product: MODEL1310110009#

metaM aps c
initial concentration: 1.0
is: CHEBI:58243
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
boundary condition: false
has only substance units: false
type: Species
name: 5'-adenylyl sulfate(2-)
is: SBO:0000247
initial amount: NaN
is: HMDB01003
constant: false

metaM dhcholoylcoa x
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:27393
is: HMDB06895
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA
boundary condition: false
type: Species
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1

metaR EX 34dhoxpeg LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxyphenylethyleneglycol exchange
type: Reaction

metaR ABTD
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
product: MODEL1310110009#
is described by: ECO:0000000
fast: false
name: L-arabinitol 4-dehydrogenase
kinetic law: MODEL1310110009#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110009#

metaR r2071
reversible: false
kinetic law: MODEL1310110009#
is: SBO:0000185
modifier: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM c16dc c
initial amount: NaN
initial concentration: 1.0
is: HMDB00712
is: SBO:0000247
type: Species
notes: FORMULA: C23H42NO6 CHARGE: -1
has only substance units: false
boundary condition: false
constant: false
name: Hexadecanedioic acid mono-L-carnitine ester

http://identifiers.org/biomodels.db/MODEL1310110009#_626d3347_5794_421b_89d4_76f4ce5a469c
constant: false
type: Species
is: B4E0V8
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: HAL
has only substance units: false
is encoded by: hsa:3034
is: SBO:0000252

metaM Tn antigen l
notes: FORMULA: C8H14NO5X CHARGE: 0
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
is: C04383
type: Species
name: Tn antigen
has only substance units: false
initial concentration: 1.0

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR CYSO
name: cysteine oxidase
is: SBO:0000176
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000269
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
is version of: http://identifiers.org/ec-code/1.13.11.20
modifier: MODEL1310110009#

metaR ALCD21 L
is version of: http://identifiers.org/ec-code/1.1.99.24
is: SBO:0000176
reversible: false
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
product: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.1
reactant: MODEL1310110009#
is described by: ECO:0000304
type: Reaction
name: alcohol dehydrogenase (L-1,2-propanediol)

metaR r2352
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110009#
fast: false
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaR r1624
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110009#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110009#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
product: MODEL1310110009#
reactant: MODEL1310110009#

metaM HC01401 m
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
is: CHEBI:27668
is: SBO:0000247
initial amount: NaN
name: (S)-3-Hydroxydodecanoyl-CoA
boundary condition: false

metaM mi1p D n
is: HMDB02985
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
type: Species
boundary condition: false
name: 1D-myo-inositol 1-phosphate(2-)
is: CHEBI:58433
initial concentration: 1.0

metaM 3ivcoa c
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/11966188
initial concentration: 1.0
constant: false
name: 3-hydroxyisovalerylcoa
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
is: C05998
is: HMDB06870

http://identifiers.org/biomodels.db/MODEL1310110009#_42d2c786_0ef8_48c4_b6ce_8576c9b02ff4
constant: false
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
name: _AA532636_1_m
initial amount: NaN
is encoded by: hsa:AA532636
initial concentration: NaN

metaM arachd e
is: CHEBI:32395
name: arachidonate
constant: false
initial concentration: 1.0
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01043

http://identifiers.org/biomodels.db/MODEL1310110009#_c2e995bd_3ecb_47ca_8b21_50c72589ec57
is encoded by: hsa:3628
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: P49441
type: Species
constant: false
boundary condition: true
name: INPP1

metaM fald e
is: HMDB01426
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
name: formaldehyde
is: CHEBI:16842
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067

http://identifiers.org/biomodels.db/MODEL1310110009#_c8012469_0b13_4302_ac5b_83f64bd6cd99
type: Species
initial concentration: NaN
boundary condition: true
name: VNN3:VNN2:VNN1
is: SBO:0000297
initial amount: NaN
constant: false
is encoded by: hsa:55350
is encoded by: hsa:8875
has part: O95498
has only substance units: false

metaR RE0512M
modifier: MODEL1310110009#
is described by: ECO:0000000
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
name: RE0512
reversible: true
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_ad456ec8_a9cd_4e73_b0d6_7b0de3aa8c6f
is encoded by: hsa:5140
is: SBO:0000252
constant: false
initial amount: NaN
is: A7E2E5
name: PDE3B
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true

metaR 5ADTSTSTERONESte
fast: false
reactant: MODEL1310110009#
is described by: ECO:0000000
reversible: true
product: MODEL1310110009#
name: sulfonated testosterone transport
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ

metaR S6TASE12ly
type: Reaction
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000176
reactant: MODEL1310110009#
reversible: true
kinetic law: MODEL1310110009#
is described by: ECO:0000000

metaR FAOXC160
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
type: Reaction
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
kinetic law: MODEL1310110009#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110009#_d7653b0d_5cdc_48bb_8381_28ffb5ec6871
is encoded by: hsa:7371
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q9BZX2
initial concentration: NaN
constant: false
name: UCK2
type: Species
boundary condition: true

metaM c226coa m
type: Species
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
name: cervonyl coenzyme A
initial amount: NaN
is: C16169
is: http://identifiers.org/pubchem.compound/47205479
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_444a7707_c5bf_4ff5_9cd5_b02b3eb2aed9
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: _AW277253_1_c
is encoded by: hsa:AW277253
constant: false
initial concentration: NaN

metaR SUBEACTD
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberic acid into cytosol (diffusion)
type: Reaction

metaR GluForTx
reactant: MODEL1310110009#
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.1.2.5
type: Reaction
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
name: Glutamate formimidoyltransferase
reversible: false
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_438c5ab9_1419_4d2b_8681_519a38f6f7af
name: PFKL
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5211
is: P17858

metaR GMPtg
reactant: MODEL1310110009#
name: GMP transport (Golgi)
product: MODEL1310110009#
is described by: ECO:0000269
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
reversible: true
type: Reaction
fast: false
is: SBO:0000185

metaR r2355
kinetic law: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
reversible: true
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110009#
fast: false
is: SBO:0000185

metaR ORPT
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.10
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110009#
name: orotate phosphoribosyltransferase
modifier: MODEL1310110009#
reversible: true
kinetic law: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#

metaM phaccoa c
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
type: Species
initial concentration: 1.0
is: HMDB06503
is: CHEBI:57390
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: phenylacetyl-CoA(4-)
boundary condition: false
constant: false

metaR CYSALANaEx
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110009#
reversible: false
reactant: MODEL1310110009#
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000269
name: L-alanine/L-cysteine Na-dependent exchange (Cys-L in)
fast: false
type: Reaction
is: SBO:0000185

metaR r1625
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110009#
reversible: true
product: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110009#

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaM CE4872 m
boundary condition: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
is: HMDB00127
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
constant: false
initial amount: NaN
type: Species
is: CHEBI:15748
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaR r0549
fast: false
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.6.99.3
is version of: http://identifiers.org/ec-code/6.1.1.17
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
type: Reaction
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.6.5.3

metaR TTDCAFATPc
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaM omhpal c
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
name: w-hydroxypalmiticacid
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C16H30O3 CHARGE: -1
is: HMDB06294
type: Species

metaM dpcoa m
initial amount: NaN
name: 3'-dephospho-CoA(2-)
has only substance units: false
is: SBO:0000247
is: HMDB01373
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:57328
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882

metaM dece3coa m
constant: false
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: 3-decenoylcoa
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4

metaM cholcoaone x
is: CHEBI:58507
constant: false
is: SBO:0000247
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
boundary condition: false
is: HMDB06891
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_1fea162f_64b0_48cd_87a9_bed0cfb95512
constant: false
is: Q02127
initial amount: NaN
name: DHODH
is: SBO:0000252
is encoded by: hsa:1723
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_574a128a_4f1f_4f5a_ae9c_fa9482b3bd80
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:122622
boundary condition: true
is: Q8N142
name: ADSSL1
type: Species
constant: false
is: SBO:0000252

metaM so3 c
is: C00094
is: CHEBI:17137
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: HMDB00240
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: Sulfite
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094

http://identifiers.org/biomodels.db/MODEL1310110009#_35e0c8d1_ae9a_4f04_aee4_3ba66abbf38b
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: ATP5D
boundary condition: true
is encoded by: hsa:513
is: P30049

metaR r2354
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM udpacgal g
initial concentration: 1.0
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
boundary condition: false
constant: false
type: Species
is: HMDB00304
name: UDP-N-acetyl-D-galactosamine(2-)
is: CHEBI:57847
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR r1626
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110009#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110009#
fast: false

metaM prostgh2 c
initial amount: NaN
has only substance units: false
name: prostaglandin H2(1-)
boundary condition: false
type: Species
is: HMDB01381
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial concentration: 1.0
constant: false
is: CHEBI:57405

http://identifiers.org/biomodels.db/MODEL1310110009#_c0a64231_1a93_4e27_8550_6456ac5deac0
is: SBO:0000297
initial concentration: NaN
boundary condition: true
has part: Q07326
has part: Q8TEQ8
has only substance units: false
is encoded by: hsa:84720
initial amount: NaN
type: Species
name: PIGF:PIGO
is encoded by: hsa:5281
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_2db045fa_ff17_43f2_86c4_d4d1a725fbec
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:3939
name: LDHA
is: P00338
constant: false
initial amount: NaN
boundary condition: true

metaR q10h2tc
reactant: MODEL1310110009#
reversible: true
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110009#
fast: false
type: Reaction
name: transport of ubiquinol into cytosol

metaM fald c
type: Species
is: HMDB01426
initial amount: NaN
boundary condition: false
name: formaldehyde
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
is: CHEBI:16842
has only substance units: false

metaM stcoa c
has only substance units: false
name: Stearoyl-CoA (n-C18:0CoA)
is: CHEBI:57394
initial concentration: 1.0
is: C00412
type: Species
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: SBO:0000247
initial amount: NaN
is: HMDB01114
constant: false
boundary condition: false

metaR FAOXC16OHC16r
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_592ddd86_2fe3_479e_aadb_75f9be23dd50
is: Q99714
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: HSD17B10
initial concentration: NaN
is encoded by: hsa:3028
boundary condition: true
is: SBO:0000252

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_4ca25960_97ba_485a_bd5a_b247d1fe200b
has only substance units: false
has part: Q14442
initial amount: NaN
has part: O94777
is encoded by: hsa:9091
is encoded by: hsa:5283
has part: Q92535
is encoded by: hsa:5279
has part: B3KUV7
has part: Q9BRB3
is encoded by: hsa:51227
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:5277
boundary condition: true
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is: SBO:0000297
is encoded by: hsa:8818

http://identifiers.org/biomodels.db/MODEL1310110009#_bdf2b273_9cf2_4116_8e2e_785592135300
boundary condition: true
name: CPT2
type: Species
is: P23786
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1376
is: SBO:0000252

metaM doco13ac e
type: Species
has only substance units: false
name: docosenoic acid (C22:1)
boundary condition: false
notes: FORMULA: C22H41O2 CHARGE: -1
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB02068

http://identifiers.org/biomodels.db/MODEL1310110009#_18381d4d_24f9_4466_8a79_b937110e8801
is encoded by: hsa:231
initial amount: NaN
name: AKR1B1
boundary condition: true
has only substance units: false
is: P15121
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaM m6mpdol U r
is: CHEBI:37635
has only substance units: false
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1605H2640N20O520P20 CHARGE: -20
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false

metaM ksii core2 deg9 l
is: HMDB00143
name: keratan sulfate II (core 2-linked), degradation product 9
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:12936
notes: FORMULA: C30H50N3O20X CHARGE: 0

metaM sphs1p r
is: HMDB00277
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: CHEBI:60119
name: sphingosine 1-phosphate(1-)
type: Species
is: SBO:0000247

metaR GGH 7DHFe
product: MODEL1310110009#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
kinetic law: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
name: Gamma-glutamyl hydrolase (7DHF), extracellular
type: Reaction
modifier: MODEL1310110009#

metaM HC02203 c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:27820
name: prostaglandin-a2
boundary condition: false
constant: false

metaR r0145
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.3.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
modifier: MODEL1310110009#
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
product: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: true

metaR CSPG Atly
name: chondroitin sulfate A transport, extracellular to lysosome
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
is described by: ECO:0000000
fast: false

metaR CYTK12
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110009#
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
name: cytidylate kinase (dCMP,dCTP)

http://identifiers.org/biomodels.db/MODEL1310110009#_8891307f_0599_4759_bb7e_150bb5cf953f
constant: false
is: Q02218
is encoded by: hsa:4967
type: Species
initial amount: NaN
boundary condition: true
name: OGDH
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM dha e
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
name: glycerone
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:16016
is: HMDB01882

metaM btn c
notes: FORMULA: C10H15N2O3S CHARGE: -1
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00030
is: CHEBI:3420
initial concentration: 1.0
type: Species
initial amount: NaN
is: C00120
name: Biotin
constant: false

metaR biomass reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
name: biomass_reaction
reversible: false
reactant: MODEL1310110009#
is described by: ECO:0000134
product: MODEL1310110009#
fast: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_9662da68_1af1_4b10_a4d9_fb4bda4d0d5d
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:205
name: AK4
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_0010d62a_5b89_4bc6_a702_47b5fea5b579
name: TXNRD1
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:7296
type: Species
initial concentration: NaN
is: Q16881

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaR r2357
product: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
reversible: true
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110009#

metaR FADH2tx
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is described by: ECO:0000000
product: MODEL1310110009#
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
name: FADH2 transporter, peroxisomal
fast: false

metaM datp c
constant: false
is: HMDB01532
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:61404
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: C00131
initial concentration: 1.0
name: dATP
boundary condition: false
type: Species

metaM dece4coa m
is: SBO:0000247
type: Species
initial concentration: 1.0
name: 4-decenoylcoa
is: HMDB02145
constant: false
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false

metaR r1620
kinetic law: MODEL1310110009#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110009#
modifier: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110009#_e848391a_4db8_4e9d_92a8_dd8173f6aa95
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2739
is: Q04760
name: GLO1
constant: false
type: Species
initial amount: NaN

metaR CYTK11
reactant: MODEL1310110009#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
product: MODEL1310110009#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dGTP)
modifier: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_b20e2ec3_1cc5_4908_8d96_9bb7d13b12c6
name: HAO1
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:54363
is: Q9UJM8
has only substance units: false

metaM prostgh2 e
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
type: Species
initial concentration: 1.0
is: HMDB01381
has only substance units: false
name: prostaglandin H2(1-)
is: SBO:0000247
boundary condition: false
is: CHEBI:57405
constant: false

metaR PYDXtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT
product: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
name: Pyridoxal transport
is: SBO:0000185
reactant: MODEL1310110009#
reversible: true
is described by: ECO:0000000
type: Reaction

metaR r2356
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR r2497
fast: false
is: SBO:0000185
reversible: false
is described by: ECO:0000000
type: Reaction
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:

metaM Tn antigen g
notes: FORMULA: C8H14NO5X CHARGE: 0
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: Tn antigen
is: C04383
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_01ef1e52_55f6_4979_aafa_20c5c40edb31
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AV727634
boundary condition: true
type: Species
is: SBO:0000252
constant: false
name: _AV727634_1_c

metaM arachdcoa x
initial amount: NaN
is: CHEBI:57368
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
constant: false
boundary condition: false
name: arachidonoyl-CoA(4-)
is: HMDB06523
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR RE1518M
reactant: MODEL1310110009#
name: RE1518
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.13
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
reversible: true
product: MODEL1310110009#
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_ea1d9e6d_5130_4836_a5cd_abac3705679d
boundary condition: true
is encoded by: hsa:51727
is: B2R6S5
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
name: CMPK1
has only substance units: false

metaM forglu c
initial amount: NaN
is: HMDB00854
name: N-Formimidoyl-L-glutamate
has only substance units: false
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: C00439
is: CHEBI:18327
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
is: SBO:0000247

metaR FACOAL160i
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
is described by: ECO:0000269
is: SBO:0000176
name: C160 fatty acid activation
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#

metaM HC01397 x
has only substance units: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
name: (S)-3-Hydroxyhexadecanoyl-CoA
is: CHEBI:27402
boundary condition: false

metaM btn e
is: SBO:0000247
notes: FORMULA: C10H15N2O3S CHARGE: -1
boundary condition: false
has only substance units: false
is: HMDB00030
is: CHEBI:3420
initial amount: NaN
type: Species
initial concentration: 1.0
is: C00120
constant: false
name: Biotin

metaR CYTK10
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
name: cytidylate kinase (CMP,dGTP)
reversible: true
is: SBO:0000176
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110009#
type: Reaction

metaR r2359
type: Reaction
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110009#
reversible: true

metaM HC02203 e
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
type: Species
is: CHEBI:27820
has only substance units: false
constant: false
name: prostaglandin-a2
boundary condition: false
initial amount: NaN

metaR r1621
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
modifier: MODEL1310110009#
is: SBO:0000185
kinetic law: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_d3ec52ee_5f89_40a9_86c4_db9eab3c4a47
name: NME2
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is: P22392
is encoded by: hsa:4831
initial amount: NaN
type: Species

metaM arachd l
initial concentration: 1.0
is: CHEBI:32395
name: arachidonate
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB01043
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
initial amount: NaN
has only substance units: false

metaM c16dc e
boundary condition: false
name: Hexadecanedioic acid mono-L-carnitine ester
initial amount: NaN
type: Species
is: HMDB00712
is: SBO:0000247
notes: FORMULA: C23H42NO6 CHARGE: -1
initial concentration: 1.0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_3f9712fc_15f5_4133_9ac8_e0d93668ad09
is: Q8WVQ1
initial amount: NaN
boundary condition: true
type: Species
name: CANT1
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:124583
is: SBO:0000252

metaM nm2masn g
is: SBO:0000247
is: C05884
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C42H70N3O30X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110009#_eac2e122_1f58_4c36_acd4_3f5f4f7d309a
initial amount: NaN
boundary condition: true
has only substance units: false
name: SLC6A12
constant: false
initial concentration: NaN
is: P48065
is: SBO:0000252
type: Species
is encoded by: hsa:6539

metaR r0545
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110009#
is: SBO:0000176
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
type: Reaction
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
product: MODEL1310110009#
reactant: MODEL1310110009#
modifier: MODEL1310110009#
fast: false
reversible: true
is described by: ECO:0000000

metaM udpacgal c
constant: false
has only substance units: false
is: HMDB00304
initial amount: NaN
boundary condition: false
is: CHEBI:57847
type: Species
is: SBO:0000247
name: UDP-N-acetyl-D-galactosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial concentration: 1.0

metaR r0142
modifier: MODEL1310110009#
type: Reaction
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110009#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
product: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
reversible: false

metaR r2358
fast: false
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110009#

metaM ksii core4 deg4 l
is: CHEBI:57455
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
name: keratan sulfate II (core 4-linked), degradation product 4
constant: false
notes: FORMULA: C66H108N6O48SX CHARGE: -1
has only substance units: false
is: HMDB01354

metaR CYSTHRNaEx
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
reversible: false
reactant: MODEL1310110009#
product: MODEL1310110009#
name: L-cysteine/L-threonine Na-dependent exchange (Cys-L in)
kinetic law: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaM cs a l
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB02183
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
type: Species
is: CHEBI:36005

metaR r1622
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110009#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110009#
type: Reaction
modifier: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#
is: SBO:0000185

metaR PHEMEt
reactant: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
kinetic law: MODEL1310110009#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
reversible: false
product: MODEL1310110009#
name: heme transport

metaM f1a l
is: HMDB02917
type: Species
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: SBO:0000247
constant: false
boundary condition: false
name: F1alpha
initial concentration: 1.0
is: CHEBI:17151
has only substance units: false
initial amount: NaN

metaR RE3002X
is version of: http://identifiers.org/ec-code/5.3.3.8
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110009#
name: RE3002
fast: false
type: Reaction
product: MODEL1310110009#
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110009#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110009#_ed9b1fc5_4775_4925_b13c_882fcbbad71f
is: SBO:0000297
is encoded by: hsa:514
initial amount: NaN
initial concentration: NaN
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is encoded by: hsa:513
boundary condition: true
has only substance units: false
constant: false
type: Species

metaM camp c
constant: false
is: CHEBI:58165
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
type: Species
is: HMDB00058
is: SBO:0000247
initial amount: NaN
name: 3',5'-cyclic AMP(1-)
has only substance units: false

metaR r0998
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#
name: Facilitated diffusion
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaM akg c
type: Species
is: SBO:0000247
is: C00026
name: 2-Oxoglutarate
initial concentration: 1.0
is: HMDB00208
constant: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:16810

metaR GMPtn
kinetic law: MODEL1310110009#
product: MODEL1310110009#
fast: false
is: SBO:0000185
name: GMP nuclear transport
reactant: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaM ksi deg5 l
is: HMDB00143
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
is: CHEBI:12936
name: keratan sulfate I, degradation product 5
is: SBO:0000247
initial concentration: 1.0

metaM cspg b e
is: CHEBI:16040
initial amount: NaN
constant: false
is: HMDB00630
has only substance units: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
boundary condition: false

metaR ALR3
fast: false
modifier: MODEL1310110009#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.21
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is: SBO:0000176
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
is described by: ECO:0000269
name: aldose reductase (acetol)

http://identifiers.org/biomodels.db/MODEL1310110009#_2634a1c6_847f_4f87_b729_ff3d5fd22df6
is encoded by: hsa:29906
name: ST8SIA5
is: O15466
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
boundary condition: true

metaR DURAD
is version of: http://identifiers.org/ec-code/1.3.1.2
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
name: dihydrouracil dehydrogenase (NADP)
reactant: MODEL1310110009#
fast: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110009#
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#

metaM retinal cis 13 r
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
name: 13-cis-retinal
is: CHEBI:45487
constant: false
is: HMDB06220
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM fad c
has only substance units: false
name: Flavin adenine dinucleotide oxidized
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:16238
is: SBO:0000247
is: C00016
boundary condition: false
is: HMDB01248

metaR r0999
reactant: MODEL1310110009#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Facilitated diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110009#_59b042cb_1773_4c74_a383_f11d2df9766b
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: Q5MY95
is: SBO:0000252
type: Species
is encoded by: hsa:377841
name: ENTPD8
boundary condition: true

metaR IPDPtx
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
type: Reaction
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000134
product: MODEL1310110009#
name: Isopentenyl diphosphate transport (peroxisome)
kinetic law: MODEL1310110009#

metaM udp e
initial concentration: 1.0
boundary condition: false
is: HMDB00295
is: SBO:0000247
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:58223
constant: false
name: UDP(3-)

metaR r0779
reactant: MODEL1310110009#
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110009#
reversible: false
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:

metaM glu L m
is: SBO:0000247
is: CHEBI:29985
is: HMDB00148
type: Species
constant: false
has only substance units: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial concentration: 1.0
boundary condition: false
name: L-glutamate(1-)
initial amount: NaN

metaR DM gpi sig er
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaM gdp c
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
name: GDP
is: CHEBI:58189
is: SBO:0000247
initial amount: NaN
is: HMDB01201
type: Species
is: C00035
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035

metaR OCDCAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
kinetic law: MODEL1310110009#
is described by: ECO:0000000
name: fatty acid transport via diffusion
is: SBO:0000185
reversible: true
reactant: MODEL1310110009#
type: Reaction
product: MODEL1310110009#

metaM orot5p c
is: HMDB00218
is: C01103
is: CHEBI:57538
name: Orotidine 5'-phosphate
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR FACOAL170
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000176
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110009#
reversible: true
name: fatty-acid--CoA ligase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
fast: false
type: Reaction

metaR r1831
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110009#
reversible: false
kinetic law: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110009#
name: Y+LAT2 Utilized transport
product: MODEL1310110009#

metaR ALR2
reversible: false
name: aldose reductase (methylglyoxal)
is: SBO:0000176
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.21
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
reactant: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_308468e8_539f_47a0_b0eb_d5cad6428c55
initial amount: NaN
name: SCD
type: Species
boundary condition: true
is: O00767
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6319

http://identifiers.org/biomodels.db/MODEL1310110009#_d8429add_a297_46c7_9124_e0c82aa5ee3b
type: Species
is: SBO:0000252
has only substance units: false
is: P14854
initial amount: NaN
is encoded by: hsa:1340
constant: false
initial concentration: NaN
boundary condition: true
name: COX6B1

http://identifiers.org/biomodels.db/MODEL1310110009#_c89e21c9_7ec1_427f_b555_8fa69f8c9861
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1636
has only substance units: false
type: Species
boundary condition: true
name: ACE
is: B4DKH4
is: SBO:0000252
constant: false

metaM ivcrn e
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
is: HMDB00688
notes: FORMULA: C12H23NO4 CHARGE: 0
is: SBO:0000247
boundary condition: false
has only substance units: false
name: isovaleryl carnitine

metaR RE3628M
fast: false
is: SBO:0000176
modifier: MODEL1310110009#
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/5.3.3.8
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
kinetic law: MODEL1310110009#
name: RE3628
type: Reaction
reversible: true
is described by: ECO:0000000

metaR ATPH1e
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.6.1.5
name: ATP diphosphohydrolase
fast: false
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (954.1) or (954.2) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
is: SBO:0000176
product: MODEL1310110009#
modifier: MODEL1310110009#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.6

metaR CMPACNAtg
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
type: Reaction
product: MODEL1310110009#
reversible: true
name: CMP-Sia Golgi transport via CMP antiport
fast: false
modifier: MODEL1310110009#
is described by: ECO:0000269
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110009#_1d2d3b4f_0a7c_42b4_8b23_fcaf31bf7082
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: G6PC2
type: Species
initial concentration: NaN
has only substance units: false
is: E9PAX2
is encoded by: hsa:57818

metaM dcholcoa r
constant: false
is: HMDB06292
is: SBO:0000247
name: chenodeoxycholoyl coenzyme a
initial concentration: 1.0
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial amount: NaN
type: Species
is: CHEBI:28701
boundary condition: false
has only substance units: false

metaM h2o2 c
is: C00027
constant: false
has only substance units: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125
is: SBO:0000247
initial amount: NaN
is: CHEBI:16240
initial concentration: 1.0
type: Species
boundary condition: false
name: Hydrogen peroxide

metaR GUMTCHOLe
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Binding of guar gums with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_37f08e61_b47e_455c_b343_f2a4c3ae0aba
boundary condition: true
is encoded by: hsa:51179
has only substance units: false
is: Q9NYQ3
name: HAO2
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is: SBO:0000252

metaR r1725
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110009#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reversible: false
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_d7d2a574_f728_46c3_810c_ef1063b74b12
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: O15382
name: BCAT2
is encoded by: hsa:587
initial amount: NaN

metaR C101CRNe
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decenoyl carnitine into extra cellular space
type: Reaction

metaR GALASE15ly
kinetic law: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110009#
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110009#

metaR NDPK8n
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000304
modifier: MODEL1310110009#
fast: false
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction

metaR VALTAm
reactant: MODEL1310110009#
modifier: MODEL1310110009#
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
is described by: ECO:0000269
product: MODEL1310110009#
name: valine transaminase, mitochondiral
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110009#

metaM udp c
has only substance units: false
type: Species
is: SBO:0000247
name: UDP
is: HMDB00295
boundary condition: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
constant: false
is: C00015
initial amount: NaN
is: CHEBI:58223
initial concentration: 1.0

metaR PYRt2r
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
reversible: true
reactant: MODEL1310110009#
modifier: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110009#
is described by: ECO:0000269
name: pyruvate reversible transport via proton symport
fast: false

metaM ha pre1 e
name: hyaluronan biosynthesis, precursor 1
boundary condition: false
type: Species
constant: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
initial concentration: 1.0
has only substance units: false
is: CHEBI:16126
initial amount: NaN
is: SBO:0000247

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaR RE3004M
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
name: RE3004
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176

metaR THBPT4ACAMDASE
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.96
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
reversible: false
reactant: MODEL1310110009#

metaM lnlnca e
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
initial amount: NaN
is: CHEBI:32387
type: Species
is: HMDB01388
name: alpha-linolenate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_00dc8ca1_6cf3_4868_98f0_98234c8a7b0f
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:5305
is: P48426
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: PIP4K2A
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_ddedc4d0_0e7c_4045_a2de_21c5b3116bb9
initial concentration: NaN
name: GGCT
initial amount: NaN
has only substance units: false
is: B8ZZR8
constant: false
type: Species
is encoded by: hsa:79017
boundary condition: true
is: SBO:0000252

metaM gln L m
is: HMDB00641
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
name: L-glutamine
is: CHEBI:18050
initial amount: NaN

metaM ivcrn c
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C12H23NO4 CHARGE: 0
is: HMDB00688
type: Species
name: isovaleryl carnitine
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_a29f86fa_7c63_405d_ac70_b2cf57bb7c25
name: HK1
is: P78542
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:3098
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_af32636f_055d_43bb_a726_5ece90e6f429
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: SLC6A9
constant: false
is encoded by: hsa:6536
is: B7Z3W8
initial concentration: NaN
boundary condition: true

metaR r0774
modifier: MODEL1310110009#
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
reactant: MODEL1310110009#
is: SBO:0000176
fast: false
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:

metaM glu L r
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
name: L-glutamate(1-)
is: CHEBI:29985
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: HMDB00148

http://identifiers.org/biomodels.db/MODEL1310110009#_e9495303_468f_4c5f_8c27_49f24d86624a
type: Species
name: NADSYN1
is encoded by: hsa:55191
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q6IA69
constant: false

metaM dcholcoa x
type: Species
boundary condition: false
is: CHEBI:28701
has only substance units: false
name: chenodeoxycholoyl coenzyme a
initial concentration: 1.0
is: HMDB06292
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337

metaR XYLTD Dr
reactant: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
name: xylitol dehydrogenase (D-xyulose-forming)
fast: false
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:

metaR r2362
fast: false
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reversible: true
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110009#

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_bf318cdb_b8f0_4898_95ad_d5fba4b03c20
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: PDE6H
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5149
is: Q13956
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_b142480c_8b06_422f_8c7c_cbf1a4098e1f
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6391
initial concentration: NaN
name: SDHC
type: Species
is: Q99643

metaM mi145p c
is: HMDB01498
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
is: CHEBI:203600
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0

metaR CSNAT2m
fast: false
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reversible: true
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.7
modifier: MODEL1310110009#
reactant: MODEL1310110009#
name: carnitine O-aceyltransferase, mitochondrial
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
type: Reaction
is: SBO:0000176

metaR r2363
reactant: MODEL1310110009#
reversible: true
is: SBO:0000185
product: MODEL1310110009#
type: Reaction
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110009#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM lnlnca c
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: CHEBI:32387
name: alpha-linolenate
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: HMDB01388
is: SBO:0000247

metaM gdp g
is: HMDB01201
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:58189
name: GDP(3-)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial amount: NaN

metaR G14T15g
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110009#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
reactant: MODEL1310110009#
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false

metaR NADPtru
is: SBO:0000185
type: Reaction
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
name: NADP transporter, endoplasmic reticulum
reversible: false

metaR HAS2
kinetic law: MODEL1310110009#
name: hyaluronan synthase
is version of: http://identifiers.org/ec-code/2.4.1.212
is: SBO:0000185
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
product: MODEL1310110009#
is described by: ECO:0000269
reactant: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
fast: false
reversible: false

metaM gm3 hs g
constant: false
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
type: Species
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:60065
is: SBO:0000247

metaR PYRt2m
fast: false
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000185
name: pyruvate mitochondrial transport via proton symport
reversible: true
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
kinetic law: MODEL1310110009#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_a5bdbb1a_120b_4f81_af27_7830cd42c331
name: NDUFA9
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is: Q16795
is encoded by: hsa:4704
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_62c26c11_5533_4d92_a21f_c35098da6a8b
boundary condition: true
initial amount: NaN
name: TXNRD2
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10587
type: Species
initial concentration: NaN
constant: false

metaR RE1573M
name: RE1573
is described by: ECO:0000000
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110009#
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_d1946793_f899_4928_aa8b_1d15b8c9ec39
has part: Q96I99
has only substance units: false
type: Species
is: SBO:0000297
is encoded by: hsa:8802
constant: false
initial amount: NaN
initial concentration: NaN
name: SUCLG2:SUCLG1
is encoded by: hsa:8801
boundary condition: true
has part: P53597

http://identifiers.org/biomodels.db/MODEL1310110009#_4db7130f_e022_41d8_bc40_f7d2d49e0b8d
is encoded by: hsa:8871
is: O15056
boundary condition: true
initial concentration: NaN
type: Species
name: SYNJ2
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaR SEBCOACROT
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_8888fd4b_fcb6_4f5a_af25_4aae194f17f1
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5288
name: PIK3C2G
constant: false
is: O75747
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN

metaR RE1807M
fast: false
kinetic law: MODEL1310110009#
type: Reaction
name: RE1807
reversible: true
reactant: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.14.13.15

http://identifiers.org/biomodels.db/MODEL1310110009#_b9c1291e_2934_4f7d_be1a_da4785f8a154
name: ACADS
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: P16219
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:35
boundary condition: true

metaR EX c81crn
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octenoyl carnitine
type: Reaction

metaR S6T1g
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
modifier: MODEL1310110009#
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
product: MODEL1310110009#

metaR r0463
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_f5a6f087_eca8_41f2_9934_d3b40b28b5d9
is: Q99755
initial amount: NaN
type: Species
constant: false
name: PIP5K1A
has only substance units: false
boundary condition: true
is encoded by: hsa:8394
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_e8a40c55_64fa_4246_b4af_91f0834a1022
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: MGST3
constant: false
is: O14880
boundary condition: true
is encoded by: hsa:4259

metaR FAOXC184C164x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)x
type: Reaction

metaR METtec
is described by: ECO:0000269
fast: false
name: L-methionine transport via diffusion (extracellular to cytosol)
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#

metaR HAS1
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
modifier: MODEL1310110009#
name: hyaluronan synthase
is described by: ECO:0000269
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.1.212
reversible: false
product: MODEL1310110009#
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110009#

metaM udp g
name: UDP(3-)
is: HMDB00295
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:58223
is: SBO:0000247
constant: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_d3f3db2f_0df1_40fb_9235_fa0de47e76c7
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: HSD11B1
boundary condition: true
is: P28845
is encoded by: hsa:3290

metaR r2360
reactant: MODEL1310110009#
fast: false
product: MODEL1310110009#
name: Organic anion transporter 5 Utilized transport
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110009#_d435e1c5_8839_4e3d_81c1_968e75ecdbe3
is: SBO:0000252
is encoded by: hsa:5148
is: P18545
has only substance units: false
type: Species
initial concentration: NaN
constant: false
boundary condition: true
name: PDE6G
initial amount: NaN

metaR RE2349C
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.6.1.64
product: MODEL1310110009#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: true
name: RE2349
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
reactant: MODEL1310110009#

metaR r2361
reversible: true
reactant: MODEL1310110009#
is: SBO:0000185
product: MODEL1310110009#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_65ffa413_a526_4c3c_8053_0b3ec5ef1dbe
type: Species
is encoded by: hsa:30
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ACAA1
constant: false
boundary condition: true
initial concentration: NaN
is: Q96CA6

metaR DNDPt41m
name: dUTP transport via dCDP antiport
is: SBO:0000185
reversible: false
modifier: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110009#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110009#

metaR r0464
product: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110009#
is: SBO:0000176
kinetic law: MODEL1310110009#
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:

metaM gdp e
name: GDP(3-)
has only substance units: false
type: Species
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial amount: NaN
initial concentration: 1.0
is: HMDB01201
is: CHEBI:58189
is: SBO:0000247
boundary condition: false
constant: false

metaM HC01397 m
initial concentration: 1.0
has only substance units: false
is: CHEBI:27402
name: (S)-3-Hydroxyhexadecanoyl-CoA
boundary condition: false
constant: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
initial amount: NaN
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_c572cf17_631e_41a7_9662_b80eb2fb70a5
initial amount: NaN
name: ACAT1
constant: false
is: P24752
has only substance units: false
is encoded by: hsa:38
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR DOLDPP Uer
is: SBO:0000176
reactant: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
kinetic law: MODEL1310110009#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.43
name: Dolichyl-diphosphate phosphohydrolase, human (uterus)
is described by: ECO:0000000
modifier: MODEL1310110009#
type: Reaction

metaR HSD3A2r
reversible: true
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
kinetic law: MODEL1310110009#
type: Reaction
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is described by: ECO:0000000
product: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.225
fast: false

metaM dece4coa x
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
name: 4-decenoylcoa
is: HMDB02145
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_21296e83_5c10_4b45_90af_4a837977b065
is encoded by: hsa:3417
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: IDH1
boundary condition: true
is: O75874
initial amount: NaN

metaR r0990
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
type: Reaction
name: Postulated transport reaction
reversible: true
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#

metaR r1921
name: Y+LAT2 Utilized transport
is: SBO:0000185
reversible: false
reactant: MODEL1310110009#
fast: false
product: MODEL1310110009#
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_e77a2e39_fb88_4805_ae2a_4b932a0c8a5f
is: Q9BT22
type: Species
initial amount: NaN
name: ALG1
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:56052
has only substance units: false
boundary condition: true

metaM oretn n
is: HMDB00224
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:58190
constant: false
notes: FORMULA: C20H27O3 CHARGE: -1 INCHI: InChI=1/C20H26O3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21)11-12-20(17,4)5/h6-10,13H,11-12H2,1-5H3,(H,22,23)/p-1
name: 4-oxo-retinoic acid

metaR FAOXC5OHc
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: (3-hydroxyisovalerylcoa-->3-hydroxyisovalerylcarnitine)c
type: Reaction

metaM cspg b l
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
initial amount: NaN
is: HMDB02183
is: CHEBI:36005
has only substance units: false
constant: false
type: Species
notes: FORMULA: C45H65N2O48S4X CHARGE: -6

metaM docohepcoa m
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
type: Species
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
name: 2,4,7,10,13,16,19-docosaheptenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110009#_a9ad0bb3_ddfc_4e7a_8a05_15374297c69e
name: PIGA
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: B3KUV7
type: Species
initial amount: NaN
is encoded by: hsa:5277
constant: false
has only substance units: false

metaM fad m
name: Flavin adenine dinucleotide oxidized
is: C00016
boundary condition: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: HMDB01248
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:16238

http://identifiers.org/biomodels.db/MODEL1310110009#_141e7b44_66b8_4a9c_99c8_6f2de6efa07d
name: ATP5E
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:514
constant: false
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_f3cd2f30_3882_4cec_a6a6_3bdb89ac5f57
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:N63787
name: _N63787_1_c
boundary condition: true
initial concentration: NaN
type: Species

metaR ADPACTD
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport into cytosol (diffusion)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_bc279c53_129c_446a_b958_d9ba9d0c9ef7
is: SBO:0000252
is: B5MCC7
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:52
type: Species
initial amount: NaN
name: ACP1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_449e0a86_1f6c_4424_a62e_66ef11afa046
name: HSD3B2
initial concentration: NaN
type: Species
is encoded by: hsa:3284
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: P26439
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_86ca2011_92b0_4b7f_985d_13cc1efbadc7
initial amount: NaN
is: Q92819
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
name: HAS2
is encoded by: hsa:3037
is: SBO:0000252
type: Species

metaR r0354
kinetic law: MODEL1310110009#
reversible: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
modifier: MODEL1310110009#
fast: false
type: Reaction
reactant: MODEL1310110009#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110009#_8a557989_56b5_4f36_a45e_19361deb398d
initial concentration: NaN
is: Q96PD7
constant: false
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:84649
name: DGAT2
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_9428f424_09c4_4634_8067_156005355284
name: SULT1A1
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6817
type: Species
constant: false

metaM succoa x
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
type: Species
is: SBO:0000247
name: Succinyl-CoA
has only substance units: false
boundary condition: false
is: HMDB01022

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_c1ec3d5b_a8a3_49e9_bc17_d63c03e093b9
name: _BF195998_1_x
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:BF195998
initial concentration: NaN
boundary condition: true
constant: false

metaM omhpal r
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C16H30O3 CHARGE: -1
is: HMDB06294
initial amount: NaN
name: w-hydroxypalmiticacid
constant: false
type: Species
boundary condition: false

metaR LEULEULAPc
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Leucylleucine in the small intestine for cellular uptake
type: Reaction

metaR XYLtly
product: MODEL1310110009#
fast: false
is: SBO:0000185
reactant: MODEL1310110009#
name: Xylose efflux from lysosome
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
kinetic law: MODEL1310110009#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110009#_f9c0fc80_050f_49da_80c4_7bdb3c98d45f
is: O75874
type: Species
has only substance units: false
constant: false
is encoded by: hsa:3417
initial concentration: NaN
name: IDH1
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_a404a556_bf45_4e3f_96b6_9588ab3e80c2
boundary condition: true
has only substance units: false
initial amount: NaN
name: GALK2
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:2585
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_17974e33_b5d8_44ea_8fd1_096aa945a9a1
is encoded by: hsa:23236
initial amount: NaN
constant: false
is: Q9NQ66
is: SBO:0000252
has only substance units: false
name: PLCB1
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_5e6a72d9_f966_4c99_95b7_34a73fe8c384
initial concentration: NaN
name: SLC6A10P
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
type: Species
is encoded by: hsa:386757
initial amount: NaN

metaR r0355
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is described by: ECO:0000000
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.3
reactant: MODEL1310110009#
is: SBO:0000176
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
fast: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1

http://identifiers.org/biomodels.db/MODEL1310110009#_b4be6666_8fd5_4228_8ba7_6b90eaa3b4c1
initial concentration: NaN
name: ALOX5
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:240
type: Species
is: P09917
initial amount: NaN

metaM gln L e
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
name: L-glutamine
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
initial concentration: 1.0
is: HMDB00641
is: CHEBI:18050
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_5d93d095_52ca_4f8e_956f_06108ea0c880
is encoded by: hsa:1718
type: Species
initial concentration: NaN
has only substance units: false
is: Q15392
constant: false
initial amount: NaN
name: DHCR24
boundary condition: true
is: SBO:0000252

metaR CMPACNAtn
fast: false
type: Reaction
reactant: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000000
name: CMP-Sia nuclear export
product: MODEL1310110009#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110009#

metaR DCK2n
type: Reaction
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
product: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000176
kinetic law: MODEL1310110009#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.74
modifier: MODEL1310110009#
name: Deoxycytidine kinase, nuclear (UTP)

metaM hxan c
name: Hypoxanthine
is: CHEBI:17368
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: C00262
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: HMDB00157
type: Species

metaM Tyr ggn e
constant: false
has only substance units: false
initial concentration: 1.0
name: Tyr-194 of apo-glycogenin protein (primer for glycogen synthesis)
type: Species
is: SBO:0000247
notes: FORMULA: XOH CHARGE: 0
is: HMDB06409
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_9509a35f_40ec_4b0d_b7d4_d958c9658c9b
has only substance units: false
name: TPH1
is: P17752
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:7166
initial amount: NaN
is: SBO:0000252
constant: false

metaM CE2705 n
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:15374
initial amount: NaN
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
name: quinonoid dihydrobiopterin
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB02281

http://identifiers.org/biomodels.db/MODEL1310110009#_bdb4b303_bb82_4072_80a7_99512edc36bb
initial concentration: NaN
type: Species
is encoded by: hsa:LOC727762
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
name: _LOC727762_1_m

http://identifiers.org/biomodels.db/MODEL1310110009#_9d661432_83db_437b_90fd_432378fcbce8
is: SBO:0000252
constant: false
is: Q16739
name: UGCG
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:7357

http://identifiers.org/biomodels.db/MODEL1310110009#_9fbdfb6b_89f9_4422_95bb_f6da5be0e8d4
is: SBO:0000252
name: ADSS
initial concentration: NaN
is: P30520
constant: false
is encoded by: hsa:159
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true

metaR r0994
name: Facilitated diffusion
kinetic law: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
type: Reaction
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110009#

metaM oaa c
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C4H2O5 CHARGE: -2
type: Species
initial concentration: 1.0
is: CHEBI:3338
is: SBO:0000247
initial amount: NaN
is: C00036
is: HMDB00223
name: Oxaloacetate

metaM pep m
initial concentration: 1.0
boundary condition: false
is: CHEBI:18021
name: Phosphoenolpyruvate
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: C00074
is: HMDB00263
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_db6c1666_e9b1_4f8b_99f4_d7a7d2321671
name: ZADH2
constant: false
is: Q4G1C4
initial concentration: NaN
is encoded by: hsa:284273
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR EX dmhptcrn LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2,6 dimethylheptanoyl carnitine exchange
type: Reaction

metaR NAt3 1
fast: false
product: MODEL1310110009#
reversible: true
is: SBO:0000185
is described by: ECO:0000269
name: sodium proton antiporter (H:NA is 1:1)
reactant: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
modifier: MODEL1310110009#

metaM gln L c
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
name: L-glutamine
is: HMDB00641
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:18050
type: Species

metaM lnlnca l
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
is: HMDB01388
is: CHEBI:32387
constant: false
name: alpha-linolenate
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR PHEACGLNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
reversible: true
kinetic law: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110009#
name: PHEACGLN extracellular transport via diffusion
type: Reaction
fast: false
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_40343858_e01b_4912_ace1_a84e02d3939c
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
name: GALNT13
has only substance units: false
is: Q8IUC8
is encoded by: hsa:114805
initial amount: NaN

metaR r0995
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
type: Reaction
reversible: true
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_26adfce9_22f4_43cd_822e_57f36bf78b6d
name: RRM2
is: P31350
type: Species
boundary condition: true
is encoded by: hsa:6241
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_edea4d9d_e14a_4e01_8599_b3dc3e1ca57f
initial concentration: NaN
name: LEFTY1
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: O75610
type: Species
has only substance units: false
is encoded by: hsa:10637

metaM hxan e
is: HMDB00157
name: hypoxanthine
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:17368
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_ef765304_25e0_41ee_9d95_2d276020de80
is encoded by: hsa:8574
is: O43488
type: Species
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: AKR7A2
boundary condition: true
is: SBO:0000252

metaM gdp n
boundary condition: false
name: GDP(3-)
initial concentration: 1.0
is: HMDB01201
is: CHEBI:58189
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035

metaM stcoa m
is: C00412
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:57394
name: Stearoyl-CoA (n-C18:0CoA)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: HMDB01114
constant: false

metaM fad e
constant: false
is: C00016
boundary condition: false
is: HMDB01248
is: CHEBI:16238
initial amount: NaN
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: SBO:0000247
name: Flavin adenine dinucleotide oxidized
initial concentration: 1.0
type: Species
has only substance units: false

metaR MM5cg
kinetic law: MODEL1310110009#
product: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000000
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.113
reactant: MODEL1310110009#
is: SBO:0000176

metaR r1721
fast: false
product: MODEL1310110009#
is: SBO:0000185
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
reversible: false
modifier: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport

metaR AMETr
type: Reaction
fast: false
reactant: MODEL1310110009#
reversible: true
name: S-Adenosyl-L-methionine intracellular diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000000

metaM ksii core2 pre9 g
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
has only substance units: false
constant: false
name: keratan sulfate II biosynthesis, precursor 9
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:28067
is: SBO:0000247

metaR KSII CORE2t
product: MODEL1310110009#
fast: false
name: keratan sulfate II (core2) transport, golgi to extracellular
is: SBO:0000185
reactant: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110009#

metaR AG13T6g
reversible: false
product: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
fast: false

metaR S6T17g
product: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
fast: false
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110009#

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_2a37e48b_d0c5_4b83_8b8b_c131a07aeef2
is encoded by: hsa:8818
boundary condition: true
has only substance units: false
initial concentration: NaN
is: O94777
type: Species
constant: false
name: DPM2
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_ac9e5aa7_5c05_4a63_9eda_115ad217f2dd
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: HAGHL
is encoded by: hsa:84264
boundary condition: true

metaR 3MOBte
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
product: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
name: Transport of 3-methyl-2-oxobutanoate
reactant: MODEL1310110009#
type: Reaction

metaR PNTOte
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#
fast: false
is described by: ECO:0000134
name: Transport of (R)-Pantothenate
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_a0aea91d_2bfe_4acb_9dad_676b2f74630d
constant: false
is: SBO:0000252
initial amount: NaN
is: E9PCP2
name: CPT1B
has only substance units: false
is encoded by: hsa:1375
initial concentration: NaN
boundary condition: true
type: Species

metaR PHACCOAGLNAC
is described by: ECO:0000000
product: MODEL1310110009#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
reactant: MODEL1310110009#
fast: false
is: SBO:0000176
type: Reaction
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_c48d0559_e09e_4543_86d2_1aeb7cf00197
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:HG2846-HT2983
initial amount: NaN
name: _HG2846_HT2983_1_m
initial concentration: NaN
constant: false
has only substance units: false

metaM gdp m
name: GDP
is: C00035
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB01201
is: CHEBI:58189

metaR RE3565C
name: RE3565
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_d383b4ad_e69a_441e_80d8_287b31c57b6a
initial concentration: NaN
is: A8K8P8
has only substance units: false
initial amount: NaN
is encoded by: hsa:2530
is: SBO:0000252
type: Species
constant: false
name: FUT8
boundary condition: true

metaM glx c
initial amount: NaN
is: HMDB00119
is: CHEBI:36655
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
name: glyoxylate
type: Species
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_74127db7_da1e_4eff_919c_b731bb09aa67
is encoded by: hsa:3418
name: IDH2
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P48735
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_5040e6b1_3829_4400_b78a_50d0d67666a9
is: P48736
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: PIK3CG
is encoded by: hsa:5294
is: SBO:0000252
has only substance units: false

metaM fol m
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00121
type: Species
name: Folate
is: SBO:0000247
is: CHEBI:27470
notes: FORMULA: C19H18N7O6 CHARGE: -1 INCHI: InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00396 EHMN_ABBREVIATION: C00504

http://identifiers.org/biomodels.db/MODEL1310110009#_bfaa676c_d552_403d_863c_e887ea3cde83
is: Q96I99
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
name: SUCLG2
is: SBO:0000252
is encoded by: hsa:8801
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_94a8adda_2fd6_4899_ab3f_2fc0559bb7a1
is: Q8NFL0
name: B3GNT7
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:93010
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_d07aec4c_76a3_496b_aaec_82e627154e06
name: NT5C2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:22978
is: SBO:0000252
constant: false
type: Species
is: P49902
boundary condition: true
initial amount: NaN

metaR r0997
type: Reaction
product: MODEL1310110009#
name: COT Facilitated diffusion
reactant: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110009#_1a6d4cdc_ff8d_4071_abcd_91a8cd492c7a
initial concentration: NaN
has only substance units: false
name: PDE9A
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:5152
constant: false

metaR BALABETAtc
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of beta alanine into the intestinal cells by beta transport system
type: Reaction

metaR r1928
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000185
reversible: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#

metaM dcholcoa c
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: chenodeoxycholoyl coenzyme a
type: Species
is: CHEBI:28701
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: HMDB06292

metaR r2066
type: Reaction
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110009#
is: SBO:0000185
product: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
reactant: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR GRTTx
name: geranyltranstransferase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.1
product: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

metaR SERGLYexR
reversible: true
name: L-Serine/Glycine reversible exchange
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110009#
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185

metaM ksii core4 pre4 g
initial concentration: 1.0
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 4
notes: FORMULA: C61H99N5O43X CHARGE: -1
boundary condition: false
constant: false
is: CHEBI:58053
type: Species
initial amount: NaN
is: C00130
is: SBO:0000247
is: HMDB00175

http://identifiers.org/biomodels.db/MODEL1310110009#_9f9bc760_da35_421e_bcc4_ffb044455c4f
name: PDE9A
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:5152
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_50d8c2bf_d061_4f65_9b6a_9ec0749d7573
is encoded by: hsa:BE042354
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
name: _BE042354_1_m

http://identifiers.org/biomodels.db/MODEL1310110009#_35acc723_384a_4a16_a4d0_498a4093b99c
initial concentration: NaN
is encoded by: hsa:7086
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
is: E7EPA7
name: TKT

metaR AG13T7g
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
reversible: false
product: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_4ae040ca_3af1_4ffb_9bad_4018f5258a3b
initial amount: NaN
constant: false
name: SLC26A6
is: SBO:0000252
is encoded by: hsa:65010
has only substance units: false
is: Q9Y3Y1
boundary condition: true
type: Species
initial concentration: NaN

metaR CLPNDt
fast: false
reversible: true
reactant: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
type: Reaction

metaR ASNALANaEx
product: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110009#
is described by: ECO:0000269
name: L-alanine/L-asparagine Na-dependent exchange (Asn-L in)

metaR r1929
modifier: MODEL1310110009#
product: MODEL1310110009#
name: Y+LAT2 Utilized transport
fast: false
type: Reaction
reactant: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_79c02e9b_908f_4a46_a5fb_89aa987d9edc
has only substance units: false
name: MTMR2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is: A6NN98
constant: false
is encoded by: hsa:8898

metaR r2065
kinetic law: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110009#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110009#
is: SBO:0000185
modifier: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false

metaM hs deg17 l
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB02704
boundary condition: false
initial amount: NaN
is: CHEBI:21338
constant: false
type: Species
name: heparan sulfate, degradation product 17

metaM pep c
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
type: Species
is: CHEBI:18021
constant: false
is: C00074
is: SBO:0000247
name: Phosphoenolpyruvate
is: HMDB00263
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR r1619
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110009#
product: MODEL1310110009#

metaM ksii core4 l
constant: false
is: CHEBI:17140
name: keratan sulfate II (core 4-linked)
is: HMDB01644
initial concentration: 1.0
type: Species
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM cortsn r
boundary condition: false
is: CHEBI:16962
is: HMDB02802
name: cortisone
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C21H28O5 CHARGE: 0 INCHI: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00762

metaR FOLR2
reactant: MODEL1310110009#
is described by: ECO:0000254
product: MODEL1310110009#
reversible: false
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
fast: false
modifier: MODEL1310110009#
name: folate reductase
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.3

metaR FUMAC
modifier: MODEL1310110009#
fast: false
is described by: ECO:0000269
name: fumarylacetoacetase
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000176
product: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.7.1.2
reversible: false
type: Reaction

metaR AICART
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.1.2.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
type: Reaction
product: MODEL1310110009#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110009#
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
fast: false

metaR r0242
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
is described by: ECO:0000000
kinetic law: MODEL1310110009#
product: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
reactant: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.1
modifier: MODEL1310110009#
reversible: true
is: SBO:0000176

metaR ALATHRNaEx
is described by: ECO:0000269
fast: false
modifier: MODEL1310110009#
reversible: false
kinetic law: MODEL1310110009#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-alanine/L-threonine Na-dependent exchange (Ala-L in)

metaM ksi deg28 l
boundary condition: false
is: HMDB01354
notes: FORMULA: C104H170N7O85S3 CHARGE: -3
constant: false
name: keratan sulfate I, degradation product 28
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57455
has only substance units: false
initial amount: NaN
type: Species

metaR BHMT
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.1.1.5
is described by: ECO:0000269
modifier: MODEL1310110009#
type: Reaction
fast: false
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000176
name: betaine-homocysteine S-methyltransferase
notes: GENE_ASSOCIATION: (23743.1) or (635.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.1.5 Confidence Level: 4 AUTHORS: PMID:9281325 NOTES:
reversible: false

metaR r2068
type: Reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110009#
is: SBO:0000185
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaM oretn c
is: CHEBI:35291
is: HMDB01852
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H27O3 CHARGE: -1 INCHI: InChI=1/C20H26O3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21)11-12-20(17,4)5/h6-10,13H,11-12H2,1-5H3,(H,22,23)/p-1
boundary condition: false
constant: false
name: 4-oxo-retinoic acid
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_f9595460_1ccd_48b6_9dcb_701cfad62484
has only substance units: false
is: SBO:0000252
type: Species
name: GNPDA2
is: Q8TDQ7
boundary condition: true
initial amount: NaN
is encoded by: hsa:132789
constant: false
initial concentration: NaN

metaM glyc3p c
initial concentration: 1.0
type: Species
has only substance units: false
name: Glycerol 3-phosphate
is: SBO:0000247
boundary condition: false
is: C00093
constant: false
is: HMDB00126
initial amount: NaN
is: CHEBI:57597
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaM fad r
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: CHEBI:16238
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB01248
has only substance units: false
initial concentration: 1.0
name: Flavin adenine dinucleotide oxidized
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_ca35b899_559e_464d_83fc_7b26e5a00813
boundary condition: true
constant: false
type: Species
is: SBO:0000252
has only substance units: false
name: TH
is encoded by: hsa:7054
initial amount: NaN
is: P78428
initial concentration: NaN

metaM b2coa m
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: crotonoyl-CoA(4-)
has only substance units: false
is: CHEBI:57332
type: Species
is: HMDB02009
is: SBO:0000247

metaR MANter
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
name: mannose efflux from endoplasmic reticulum
fast: false
reactant: MODEL1310110009#
is: SBO:0000185
kinetic law: MODEL1310110009#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_7bd51f5a_88c0_40f0_b556_ee7cc979ad55
is: A8MU28
constant: false
is: SBO:0000252
name: NAE1
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8883
type: Species
initial amount: NaN

metaR TRPHYDRO2
reversible: false
is described by: ECO:0000269
product: MODEL1310110009#
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.14.16.4
reactant: MODEL1310110009#

metaR P45027A11m
product: MODEL1310110009#
reactant: MODEL1310110009#
reversible: false
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
is described by: ECO:0000269
type: Reaction
fast: false
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase

http://identifiers.org/biomodels.db/MODEL1310110009#_37796580_e6eb_408f_83d6_4e095f2dbbd0
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:4702
name: NDUFA8
boundary condition: true
is: B1AM93
initial concentration: NaN
constant: false
initial amount: NaN

metaR ILEt5m
product: MODEL1310110009#
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
fast: false
name: Isoleucine mitochondrial transport

metaM dttp n
initial concentration: 1.0
is: SBO:0000247
is: HMDB01342
name: dTTP
boundary condition: false
is: CHEBI:37568
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: C00459
has only substance units: false

metaR r0139
is described by: ECO:0000000
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.2.2
product: MODEL1310110009#
type: Reaction
modifier: MODEL1310110009#
is: SBO:0000176
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5

metaR r1617
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_7df7e622_8280_48b3_aebb_cd653ba9ee58
is: Q9ULC5
name: ACSL5
constant: false
is encoded by: hsa:51703
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_fbd6df59_3be4_405c_b0cb_edb487080b26
is: O00400
initial concentration: NaN
is: SBO:0000252
type: Species
name: SLC33A1
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:9197

metaR NACHEX22ly
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
kinetic law: MODEL1310110009#
fast: false
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
product: MODEL1310110009#
modifier: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_81f0dfe0_9011_4428_9c70_7e89b5df7085
is encoded by: hsa:4714
boundary condition: true
name: NDUFB8
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: O95169

metaR ADNt
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is described by: ECO:0000269
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
product: MODEL1310110009#
reversible: true
is: SBO:0000185
name: adenosine facilated transport in cytosol
type: Reaction
reactant: MODEL1310110009#
fast: false

metaM ksii core4 e
is: CHEBI:17268
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial amount: NaN
is: HMDB00211
name: keratan sulfate II (core 4-linked)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_555c0779_c374_4305_ae9f_7e916ff8fb35
constant: false
type: Species
name: SLC6A9
is encoded by: hsa:6536
has only substance units: false
boundary condition: true
is: SBO:0000252
is: P48067
initial concentration: NaN
initial amount: NaN

metaM 4fumacac c
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:18034
name: 4-fumarylacetoacetate(2-)
initial concentration: 1.0
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB01268

http://identifiers.org/biomodels.db/MODEL1310110009#_5bfe369d_f65e_4a48_b9e7_b221778c88ee
constant: false
has only substance units: false
is encoded by: hsa:10841
type: Species
initial concentration: NaN
is: SBO:0000252
name: FTCD
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_3ed85c23_4455_463a_961b_723eb84e29b3
type: Species
is encoded by: hsa:4645
has only substance units: false
is: SBO:0000252
name: MYO5B
initial amount: NaN
initial concentration: NaN
constant: false
is: Q9H6Y6
boundary condition: true

metaR r1618
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000000
kinetic law: MODEL1310110009#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
modifier: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_eb624d1a_ee94_4035_a30f_72b1a6de58fc
is encoded by: hsa:50487
constant: false
initial concentration: NaN
is: Q9NZ20
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: PLA2G3
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_10349c92_1e9a_47fe_b32f_a04d05a76a02
initial amount: NaN
boundary condition: true
has only substance units: false
name: HIBCH
is: SBO:0000252
is encoded by: hsa:26275
type: Species
initial concentration: NaN
is: Q6NVY1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_d6c155fa_f7af_46dc_a1ed_980c244a590e
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:10005
is: SBO:0000252
name: ACOT8
initial concentration: NaN
boundary condition: true
is: O14734
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_30954e62_7282_4293_b1dc_16ecf9ebfa3d
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
name: NDUFB11
is: Q9NX14
is encoded by: hsa:54539
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_427e3dba_2b0f_4e81_9a3b_ac7f228f1caa
constant: false
is: B4DX62
is encoded by: hsa:6487
name: ST3GAL3
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaR S6TASE10ly
kinetic law: MODEL1310110009#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110009#
reactant: MODEL1310110009#
name: galactose-6-sulfate sulfatase, lysosomal
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR CREATt4 2 r
type: Reaction
reversible: true
reactant: MODEL1310110009#
is: SBO:0000185
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
name: Creatine transport (sodium symport) (2:1)
modifier: MODEL1310110009#
is described by: ECO:0000269
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_8333997a_50b7_43f2_8e28_943f0eff31c1
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:M68895
has only substance units: false
type: Species
is: SBO:0000252
name: _M68895_1_c
initial amount: NaN

metaM fol e
name: Folate
boundary condition: false
constant: false
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial amount: NaN
is: HMDB00121
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_2c5c5b0f_f856_4807_812d_1b1e1ec098ce
is encoded by: hsa:5091
is: P11498
name: PC
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
boundary condition: true

metaM 3hddcoa m
constant: false
initial amount: NaN
is: HMDB11123
is: SBO:0000247
boundary condition: false
name: (S)-3-Hydroxydodecanoyl-CoA
has only substance units: false
is: C05279
initial concentration: 1.0
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_0bfa7e43_22df_4757_a541_952efaa5c670
is encoded by: hsa:114112
initial amount: NaN
is: Q86VQ6
constant: false
has only substance units: false
name: TXNRD3
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true

metaM CE2705 c
is: CHEBI:36781
is: SBO:0000247
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: quinonoid dihydrobiopterin

metaR r1615
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110009#
product: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110009#

metaM 3hmbcoa m
initial concentration: 1.0
is: HMDB01356
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
boundary condition: false
constant: false
type: Species
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
is: CHEBI:57312

metaR r1401
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.7.10.1
fast: false
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.1.1.3
is version of: http://identifiers.org/ec-code/3.2.1.35
is version of: http://identifiers.org/ec-code/2.3.1.51
reactant: MODEL1310110009#
name: Facilitated diffusion
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.41
is described by: ECO:0000000
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_acc6e693_820b_4b5a_adb5_859060a0c642
is encoded by: hsa:79053
initial concentration: NaN
type: Species
is: Q9BVK2
name: ALG8
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252

metaR M7MASNBterg
name: m7masnB transport from endoplasmic reticulum to Golgi apparatus
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
type: Reaction
is: SBO:0000185
product: MODEL1310110009#
is described by: ECO:0000000
fast: false

metaM ksii core4 g
is: HMDB01644
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:17140
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
is: SBO:0000247
type: Species
name: keratan sulfate II (core 4-linked)

metaM oaa m
is: HMDB00223
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16452
boundary condition: false
is: C00036
is: SBO:0000247
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
constant: false
name: Oxaloacetate
has only substance units: false

metaR ACNAMtn
kinetic law: MODEL1310110009#
is: SBO:0000185
reversible: false
name: N-acetylneuraminate nuclear import
reactant: MODEL1310110009#
type: Reaction
fast: false
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_67b8c217_2437_4ea5_9cef_99cec864af26
is: P49247
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:22934
name: RPIA
has only substance units: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_5cce55dd_f15e_40f1_84c6_b647ad9795c3
type: Species
has only substance units: false
is: F5GWS5
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:55811
name: ADCY10
boundary condition: true

metaR SBTD D2
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.14
reversible: false
notes: GENE_ASSOCIATION: (6652.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.14 Confidence Level: 0 AUTHORS: PMID:14965227 NOTES:NCD
name: D-sorbitol dehydrogenase (D-fructose producing)
type: Reaction
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110009#

metaR r1616
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110009#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_c32086fd_510a_4fba_abcc_56f7c6830556
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: _AA576959_1_c
initial concentration: NaN
is encoded by: hsa:AA576959
boundary condition: true

metaR FACOAL180i
reversible: false
modifier: MODEL1310110009#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110009#
type: Reaction
name: C180 fatty acid activation
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
product: MODEL1310110009#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_6c4bcf9a_9db9_401f_bf12_44d60cbab0f8
name: ODC1
type: Species
is: SBO:0000252
initial amount: NaN
is: P11926
is encoded by: hsa:4953
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

metaM akg m
constant: false
name: 2-Oxoglutarate
initial amount: NaN
has only substance units: false
is: C00026
boundary condition: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
type: Species
is: CHEBI:16810
is: HMDB00208
is: SBO:0000247
initial concentration: 1.0

metaR AHEXASE2ly
is: SBO:0000176
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
product: MODEL1310110009#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110009#_c65d283b_cc2f_4d16_8294_3a050f7f0759
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2590
type: Species
name: GALNT2
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
is: Q10471

http://identifiers.org/biomodels.db/MODEL1310110009#_afb6271a_ac1e_4bfc_b9b9_b56d1d220e05
is: P55084
is encoded by: hsa:3032
name: HADHB
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_281865e9_8795_4f36_99ae_a09d14f3835f
is: Q6P4B4
type: Species
is encoded by: hsa:5198
name: PFAS
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR r2367
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
product: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110009#
name: Organic anion transporter 5 Utilized transport

metaR GLUPRT
reversible: false
product: MODEL1310110009#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.14
modifier: MODEL1310110009#
fast: false
type: Reaction
reactant: MODEL1310110009#
name: glutamine phosphoribosyldiphosphate amidotransferase
kinetic law: MODEL1310110009#

metaR FCOAH
reversible: false
name: formyl coa hydrolase
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11341778,PMID:11591435 NOTES:Note - formcoa formula is uncharged - the correct is FACOAH2 w/ forcoa NJ
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110009#
product: MODEL1310110009#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_c2f4c4ea_06bc_460d_b547_53ecab108446
initial concentration: NaN
name: AK3
is encoded by: hsa:50808
initial amount: NaN
type: Species
is: E7ET30
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false

metaR r1613
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR SO4tl
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
type: Reaction
product: MODEL1310110009#
name: Sulfate transport (lysosome)
kinetic law: MODEL1310110009#
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110009#_180d482a_2d0d_4ff2_b86d_dbf08f6bd223
is: Q9NR45
has only substance units: false
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:54187
name: NANS
initial concentration: NaN
initial amount: NaN

metaM fol c
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C19H18N7O6 CHARGE: -1
has only substance units: false
name: Folate
initial concentration: 1.0
is: HMDB00121
type: Species
constant: false

metaM udp m
is: HMDB00295
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:58223
is: SBO:0000247
initial concentration: 1.0
name: UDP(3-)
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
constant: false

metaR r0783
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
is described by: ECO:0000000
product: MODEL1310110009#
reversible: true
is: SBO:0000176
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
fast: false
type: Reaction

metaR HPDCACRNCPT1
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (1375.2) or (1375.3) or (1374.1) or (126129.1) or (1375.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
product: MODEL1310110009#
fast: false
name: carnitine fatty-acyl transferase
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110009#_22e09221_43f8_4625_ac3f_3ce37d31d738
name: GUCY1A2:GUCY1B3
type: Species
has only substance units: false
has part: P33402
boundary condition: true
is encoded by: hsa:2977
is: SBO:0000297
has part: Q02153
is encoded by: hsa:2983
initial concentration: NaN
initial amount: NaN
constant: false

metaM ksi pre36 g
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 36
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_7233836f_3258_4721_b485_6308328b39da
name: NDUFB4
boundary condition: true
is encoded by: hsa:4710
type: Species
constant: false
is: O95168
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM lcts e
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
name: Lactose
is: HMDB00186
is: CHEBI:17716
initial concentration: 1.0
boundary condition: false
constant: false
is: C00243
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaM dttp c
is: HMDB01342
has only substance units: false
initial amount: NaN
is: C00459
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
boundary condition: false
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
name: dTTP
is: CHEBI:37568

metaM hs deg8 l
name: heparan sulfate, degradation product 8
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
initial amount: NaN
is: CHEBI:16126
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_00630d32_71b1_406c_8771_6b5d7c789e85
is: SBO:0000252
has only substance units: false
type: Species
name: SLC1A4
initial amount: NaN
is encoded by: hsa:6509
constant: false
initial concentration: NaN
boundary condition: true
is: P43007

metaR r2366
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110009#
reversible: true
kinetic law: MODEL1310110009#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110009#

metaR r1614
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110009#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110009#
is: SBO:0000185
reactant: MODEL1310110009#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_386428a8_18a7_4faa_aa83_f739b22d0f8d
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3030
constant: false
boundary condition: true
name: HADHA
is: E9KL44
type: Species

metaR GTHOm
is described by: ECO:0000254
fast: false
reactant: MODEL1310110009#
name: glutathione oxidoreductase
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
kinetic law: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.7
reversible: false
is: SBO:0000176
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_41841712_a883_44fe_84fa_e85a7fd2679c
name: SYNJ1
is encoded by: hsa:8867
is: C9JFZ1
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN

metaR S2TASE2ly
is: SBO:0000176
fast: false
name: iduronate-2-sulfatase, lysosomal
reactant: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.1.6.13
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
modifier: MODEL1310110009#
reversible: false

metaR TRDR
fast: false
name: thioredoxin reductase (NADPH)
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.8.1.9
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
is described by: ECO:0000269

metaM udp n
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
name: UDP(3-)
constant: false
is: HMDB00295
boundary condition: false
is: CHEBI:58223
initial concentration: 1.0

metaR ECOAH9m
is described by: ECO:0000304
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is: SBO:0000176
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110009#
fast: false
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial

metaM zym int2 r
initial concentration: 1.0
initial amount: NaN
is: CHEBI:52386
type: Species
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
name: zymosterol intermediate 2
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_4244a5e1_018d_4d0c_b80e_279a3a4ff554
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AA788780
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
name: _AA788780_1_c

metaR C12OHc
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdodecanoylcarnitinec
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_d9f61774_b981_474a_a646_cb30305050eb
is encoded by: hsa:5287
type: Species
is: O00750
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: PIK3C2B
boundary condition: true
is: SBO:0000252

metaR MANt4
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
modifier: MODEL1310110009#
reversible: true
type: Reaction
name: D-mannose transport via sodium cotransport
reactant: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110009#
product: MODEL1310110009#
fast: false

metaM gal1p c
is: CHEBI:58336
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB00645
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate

http://identifiers.org/biomodels.db/MODEL1310110009#_37f7b535_0af0_480c_af8e_34feb4f373a4
name: DUT
boundary condition: true
is: P33316
type: Species
initial concentration: NaN
is encoded by: hsa:1854
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN

metaR HS3ly
kinetic law: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.10.1.1
is: SBO:0000176
name: heparan-N-sulfatase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
product: MODEL1310110009#
type: Reaction
reversible: false
modifier: MODEL1310110009#

metaR r1611
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaR r2365
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110009#
is: SBO:0000185
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
reversible: true
type: Reaction
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110009#_f032b0cd_b42f_4677_8514_f34b848d522e
is: SBO:0000252
is encoded by: hsa:5833
constant: false
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: F5H8B1
name: PCYT2

metaR r0781
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
reactant: MODEL1310110009#
product: MODEL1310110009#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
fast: false
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
type: Reaction
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:

metaM c3dc c
is: HMDB02095
notes: FORMULA: C10H16NO6 CHARGE: -1
name: malonyl carnitine
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species

metaM srtn c
boundary condition: false
is: HMDB00259
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:350546
type: Species
name: serotonin(1+)
has only substance units: false
initial concentration: 1.0

metaR GALASE9ly
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000000
fast: false
name: beta-galactosidase, lysosomal
reversible: false
reactant: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR EX ahdt LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 7,8-dihydroneopterin 3-triphosphate(4-)
type: Reaction

metaR THP2Ctp
reactant: MODEL1310110009#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
is: SBO:0000185
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
is described by: ECO:0000000
product: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_bab74ea8_17ea_4311_881a_21d665c63c06
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: TXNRD2
is encoded by: hsa:10587
constant: false

metaR r0559
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
product: MODEL1310110009#
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false

metaR MI145PP
is described by: ECO:0000269
name: inositol-1,4,5-trisphosphate 5-phosphatase
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.36
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.56
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.86
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
reversible: false

metaR PPD2CSPp
reversible: false
kinetic law: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
type: Reaction
is described by: ECO:0000000
name: PPD2CSPp

metaM l2n2m2mn l
initial concentration: 1.0
notes: FORMULA: C54H91N3O41 CHARGE: 0
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
is: HMDB00143
type: Species
is: CHEBI:12936
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR r2364
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110009#
product: MODEL1310110009#
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaR r1612
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110009#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110009#
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_1b8c3162_f54e_41eb_baf0_c41ee6af2cff
boundary condition: true
name: HSD17B4
has only substance units: false
is: E9PB82
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:3295

metaM ha pre1 l
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:16126
name: hyaluronan biosynthesis, precursor 1
constant: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_109fda96_3eaf_4422_bcdd_0b6a6710567b
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
name: MTHFS
is encoded by: hsa:10588
constant: false
initial amount: NaN
is: P49914

metaR DMNONCRNt
fast: false
name: 4,8 dimethylnonanoyl carnitine transport (mitochondria)
is: SBO:0000185
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
is described by: ECO:0000000

metaR r0780
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
product: MODEL1310110009#
reversible: true
modifier: MODEL1310110009#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
kinetic law: MODEL1310110009#
is: SBO:0000176
fast: false
type: Reaction

metaM udp l
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
name: UDP(3-)
type: Species
is: HMDB00295
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: CHEBI:58223
initial concentration: 1.0

metaR BPNT
is described by: ECO:0000269
product: MODEL1310110009#
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.1.3.7
kinetic law: MODEL1310110009#
name: 3',5'-bisphosphate nucleotidase
is: SBO:0000176
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
reactant: MODEL1310110009#
type: Reaction
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110009#_8947f7ad_df62_4caf_8151_57da02ce8e7f
has only substance units: false
is encoded by: hsa:D29675
type: Species
initial amount: NaN
name: _D29675_1_e
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true

metaR HPDCACRNCPT2
product: MODEL1310110009#
is: SBO:0000176
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
kinetic law: MODEL1310110009#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
name: heptadecanoate transport into the mitochondria
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110009#

metaR r0558
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.3
kinetic law: MODEL1310110009#
product: MODEL1310110009#
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
is: SBO:0000176
reversible: true
fast: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
type: Reaction
modifier: MODEL1310110009#
reactant: MODEL1310110009#

metaM udp r
initial concentration: 1.0
is: HMDB00295
constant: false
is: CHEBI:58223
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: C00015
is: SBO:0000247
boundary condition: false
has only substance units: false
name: UDP
type: Species
initial amount: NaN

metaM srtn e
name: serotonin(1+)
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB00259
is: CHEBI:350546

http://identifiers.org/biomodels.db/MODEL1310110009#_c7d0ff40_cf70_4122_9706_976fd7a77199
is encoded by: hsa:644
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is: P53004
constant: false
is: SBO:0000252
name: BLVRA

metaR C8DCc
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_be7a7b01_6f1a_4e9b_a8c4_132625fe8bf3
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:522
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: ATP5J
has only substance units: false
is: P18859

metaR 4HOXPACDOX NADP
kinetic law: MODEL1310110009#
type: Reaction
reversible: true
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
product: MODEL1310110009#
is: SBO:0000176
fast: false

metaM retinal c
is: HMDB01358
boundary condition: false
has only substance units: false
constant: false
name: retinal
type: Species
is: CHEBI:15035
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_7423966a_8df9_4ef8_90af_a1d3a281bcc1
type: Species
is: Q9H310
name: RHBG
boundary condition: true
is encoded by: hsa:57127
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_f244ccbc_b808_48d8_b1c6_26abc9e1f3dc
is: Q9NRZ7
initial amount: NaN
type: Species
name: AGPAT3
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:56894
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_15651ec6_26cc_4809_8237_184ab1c3afaa
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1384
type: Species
name: CRAT
constant: false
is: P43155
initial concentration: NaN
boundary condition: true

metaR r2061
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: false
modifier: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM adrnl c
is: SBO:0000247
is: HMDB00068
type: Species
is: CHEBI:33568
notes: FORMULA: C9H14NO3 CHARGE: 1 INCHI: InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3 EHMN_ABBREVIATION: C00788
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: Adrenaline
constant: false
boundary condition: false

metaR r1610
kinetic law: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaR THFtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is described by: ECO:0000000
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
kinetic law: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
is: SBO:0000185
reversible: true

metaR CHOLESTle
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.1.1.13
reactant: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
name: hydrolysis of cholesterol ester by cholesterol esterase
reversible: false
modifier: MODEL1310110009#
fast: false

metaR DDPGAm
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
product: MODEL1310110009#
is: SBO:0000176

metaR r0130
reactant: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110009#
is described by: ECO:0000000
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
product: MODEL1310110009#

metaR UMPK7n
kinetic law: MODEL1310110009#
reversible: true
modifier: MODEL1310110009#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110009#
name: UMP kinase (dGTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is: SBO:0000176

metaM fad x
is: SBO:0000247
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
name: Flavin adenine dinucleotide oxidized
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: HMDB01248
boundary condition: false
is: CHEBI:16238
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_dd2cda68_9fee_4f8a_bd6b_d6dacdfc35a8
initial amount: NaN
is: SBO:0000252
name: GGT5
initial concentration: NaN
is encoded by: hsa:2687
constant: false
is: P36269
has only substance units: false
type: Species
boundary condition: true

metaR r0556
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.19.1
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
type: Reaction
product: MODEL1310110009#
reactant: MODEL1310110009#
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61

metaM 5eipencoa m
type: Species
boundary condition: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: 5,8,11,14,17-eicosapentenoylcoa
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0

metaR RE1517M
reactant: MODEL1310110009#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
fast: false
name: RE1517
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.3.99.13
modifier: MODEL1310110009#
reversible: true
product: MODEL1310110009#
kinetic law: MODEL1310110009#

metaR MI145PK
name: inositol-1,4,5-trisphosphate 3-kinase
type: Reaction
kinetic law: MODEL1310110009#
fast: false
product: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.1.127
is described by: ECO:0000269
reversible: false

metaR FAOXC226m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

metaR r2060
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
type: Reaction
product: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR RE3627M
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
name: RE3627
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110009#_ce2a9776_1a0a_40cf_9852_448d3e663aa6
has only substance units: false
is: SBO:0000252
is encoded by: hsa:50
type: Species
boundary condition: true
name: ACO2
initial concentration: NaN
constant: false
is: Q99798
initial amount: NaN

metaR r0246
is described by: ECO:0000000
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.5.1.3
product: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
reversible: false
modifier: MODEL1310110009#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
type: Reaction
is: SBO:0000176
fast: false

metaR AIRCr
is version of: http://identifiers.org/ec-code/6.3.2.6
fast: false
type: Reaction
name: phosphoribosylaminoimidazole carboxylase
reactant: MODEL1310110009#
reversible: true
modifier: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110009#
is described by: ECO:0000269

metaM succoa m
type: Species
is: HMDB01022
is: CHEBI:57292
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
initial concentration: 1.0
name: Succinyl-CoA
has only substance units: false

metaR DTDPtn
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110009#
name: dTDP nuclear transport
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#

metaR r2369
product: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
fast: false
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110009#_a2444b48_b08f_462d_8226_e9739c8a5aa5
name: _D29675_1_c
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:D29675
constant: false
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_aef9b831_5f20_461b_8242_84db300f9c32
type: Species
is encoded by: hsa:130
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is: P28332
name: ADH6

http://identifiers.org/biomodels.db/MODEL1310110009#_98fb5785_edf7_49b3_9584_1cea498ec67b
is encoded by: hsa:39
initial amount: NaN
constant: false
is: SBO:0000252
name: ACAT2
boundary condition: true
initial concentration: NaN
is: Q9BWD1
type: Species
has only substance units: false

metaR CSNAT2x
is version of: http://identifiers.org/ec-code/2.3.1.137
is described by: ECO:0000269
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
is version of: http://identifiers.org/ec-code/2.3.1.7
reversible: true
fast: false
is: SBO:0000176
modifier: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
product: MODEL1310110009#
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_85ff9bbd_9d70_44f3_9b47_c2343bc14496
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2271
name: FH
initial amount: NaN
type: Species
is: P07954

metaR r2063
is described by: ECO:0000000
reactant: MODEL1310110009#
product: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110009#
is: SBO:0000185
reversible: false
type: Reaction
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_71673649_eec2_418a_9539_06aed9739c82
initial concentration: NaN
is: P00491
has only substance units: false
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:4860
initial amount: NaN
name: PNP
boundary condition: true

metaM akg e
boundary condition: false
initial concentration: 1.0
is: CHEBI:16810
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
has only substance units: false
type: Species
is: HMDB00208
name: 2-oxoglutarate(2-)

http://identifiers.org/biomodels.db/MODEL1310110009#_9fa1662e_8270_4442_9522_2a57a0559dca
boundary condition: true
initial amount: NaN
is encoded by: hsa:H17063
name: _H17063_1_c
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN

metaR r2368
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110009#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000

metaR r0245
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.5.1.3
type: Reaction
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110009#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110009#_e55d52ff_ed70_4606_899e_aa9d4b563042
name: PDE6A:PDE6C:PDE6D:PDE6G:PDE6B
is encoded by: hsa:5147
has only substance units: false
is encoded by: hsa:5148
type: Species
boundary condition: true
constant: false
has part: P18545
initial concentration: NaN
initial amount: NaN
has part: O43924
is: SBO:0000297

metaM dttp e
name: dTTP(4-)
type: Species
has only substance units: false
constant: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: SBO:0000247
boundary condition: false
is: CHEBI:37568
initial concentration: 1.0
is: HMDB01342
initial amount: NaN

metaM lcts g
is: SBO:0000247
is: CHEBI:17716
is: HMDB00186
has only substance units: false
constant: false
type: Species
name: lactose
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11?,12+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243

metaM ksi pre17 g
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 17
constant: false
is: CHEBI:28067
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_3b0122e7_0717_4d4f_9c48_27f246c23326
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:5538
initial amount: NaN
type: Species
is: Q6FGQ4
name: PPT1

http://identifiers.org/biomodels.db/MODEL1310110009#_c1a71c57_283d_49a7_ba18_0d0a7cf4c3f1
has only substance units: false
constant: false
is: P17568
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:4713
is: SBO:0000252
name: NDUFB7
boundary condition: true

metaR r2062
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110009#
product: MODEL1310110009#
modifier: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

http://identifiers.org/biomodels.db/MODEL1310110009#_ebe71062_05b4_4961_ab1f_626fcbface1e
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:7054
boundary condition: true
name: TH
initial amount: NaN

metaR DURIPP
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110009#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
kinetic law: MODEL1310110009#
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110009#
name: deoxyuridine phosphorylase
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.2.3

metaR r1050
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
reversible: true
product: MODEL1310110009#
name: Vesicular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:

metaM cgly c
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
has only substance units: false
is: HMDB00078
initial concentration: 1.0
name: L-cysteinylglycine
constant: false
is: CHEBI:4047

metaM dgcholcoa x
initial amount: NaN
is: C05461
has only substance units: false
name: Chenodeoxyglycocholoyl-CoA
constant: false
is: SBO:0000247
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24?,25-,26+,27?,28?,29?,30+,31+,34?,36+,37+,38?,42+,44-,45+/m0/s1 EHMN_ABBREVIATION: C05461
initial concentration: 1.0
boundary condition: false
is: HMDB06897
type: Species

metaM glysar c
name: Glycylsarcosine
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C5H10N2O3 CHARGE: 0
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/93131

metaR SFGTH
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
modifier: MODEL1310110009#
product: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#
name: S-Formylglutathione hydralase
is version of: http://identifiers.org/ec-code/3.1.2.12
kinetic law: MODEL1310110009#
type: Reaction
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110009#_9c214624_7c61_4087_ba7c_e43f7588ccc3
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaM l2fn2m2masn g
has only substance units: false
boundary condition: false
is: CHEBI:28067
constant: false
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
type: Species
notes: FORMULA: C68H113N4O49X CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_c65616fa_c558_4fb0_80c6_c3df464a9d34
initial amount: NaN
boundary condition: true
type: Species
is: E9PDK1
name: SLC4A9
is encoded by: hsa:83697
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_5be518d4_8e6b_4b13_b5ea_44e8f518f505
is: Q9UHI5
boundary condition: true
is encoded by: hsa:23428
initial concentration: NaN
name: SLC7A8
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaR CYTDt
kinetic law: MODEL1310110009#
reversible: true
modifier: MODEL1310110009#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110009#
name: cytidine facilated transport in cytosol
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
fast: false
product: MODEL1310110009#

metaR RE3524R
is: SBO:0000176
kinetic law: MODEL1310110009#
reversible: true
name: RE3524
product: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
type: Reaction
fast: false

metaR r1051
type: Reaction
reactant: MODEL1310110009#
reversible: true
product: MODEL1310110009#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110009#
name: Vesicular transport

metaR r0960
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
product: MODEL1310110009#
fast: false

metaM HC02217 e
name: prostaglandin-g2
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:27647
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956

metaR DHCRD2
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110009#
modifier: MODEL1310110009#
product: MODEL1310110009#
name: dihydroceramide desaturase
kinetic law: MODEL1310110009#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_eb417b25_85a6_4590_9bbe_5c28ce63aa07
type: Species
is: SBO:0000252
is encoded by: hsa:84889
boundary condition: true
initial amount: NaN
has only substance units: false
name: SLC7A3
constant: false
initial concentration: NaN
is: Q8WY07

http://identifiers.org/biomodels.db/MODEL1310110009#_6d924b8f_cd62_4564_94f8_1f0d7cc96713
is encoded by: hsa:197257
constant: false
name: LDHD
initial concentration: NaN
has only substance units: false
is: Q86WU2
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_ea075df5_1a6c_4e25_9969_2f1c82ad70ec
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:3423
is: SBO:0000252
name: IDS
constant: false
initial concentration: NaN
is: B4DGD7

metaM accoa c
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: C00024
name: Acetyl-CoA
is: HMDB01206
is: CHEBI:57288
boundary condition: false
constant: false

metaR r1052
fast: false
reactant: MODEL1310110009#
product: MODEL1310110009#
reversible: false
type: Reaction
name: Vesicular transport
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
is described by: ECO:0000000
is: SBO:0000185

metaR r1466
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
is: SBO:0000176
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
type: Reaction
name: EC:2.3.1.86

http://identifiers.org/biomodels.db/MODEL1310110009#_d45b98c3_17c3_4a1b_8cb3_26878056c870
type: Species
is encoded by: hsa:BE966236
has only substance units: false
initial concentration: NaN
name: _BE966236_1_c
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_26327ce8_3bab_49b5_9037_4c3ecae9e833
initial amount: NaN
boundary condition: true
has only substance units: false
name: MPI
is: SBO:0000252
type: Species
is: P34949
is encoded by: hsa:4351
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_9ab21a34_1fe4_405b_ae86_274418fdbb4b
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:51022
is: Q9NS18
name: GLRX2
has only substance units: false

metaR CYSGLYexR
product: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: true
name: L-cysteine/glycine reversible exchanger
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
modifier: MODEL1310110009#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110009#
fast: false

metaM m3mpdol U c
has only substance units: false
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human uterine homolog
constant: false
notes: FORMULA: C1425H2340N20O370P20 CHARGE: -20
is: CHEBI:37632
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_ac528450_5b3c_4fbb_acc2_00490e3030eb
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaM prostge1 c
is: HMDB01442
constant: false
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:57397
initial concentration: 1.0
name: prostaglandin E1(1-)

metaR RE3245C
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110009#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
kinetic law: MODEL1310110009#
product: MODEL1310110009#
name: RE3245
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110009#_11598a1f_82ee_4916_9d44_b134a466717c
name: AKR1A1
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:10327

metaR r1467
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110009#
name: Postulated transport reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#

metaM s2l2fn2m2masn e
is: C00255
is: CHEBI:3554
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C90H145N6O65X CHARGE: -2
is: HMDB00244
constant: false
initial amount: NaN
name: PA6
is: SBO:0000247
type: Species

metaM biocyt c
is: http://identifiers.org/pubchem.compound/7886
is: HMDB03134
initial amount: NaN
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: C05552
name: Biocytin
is: SBO:0000247
constant: false

metaM sprm e
has only substance units: false
initial concentration: 1.0
is: HMDB01256
boundary condition: false
name: spermine(4+)
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:45725
constant: false
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750

http://identifiers.org/biomodels.db/MODEL1310110009#_795fa930_00d2_451a_95dd_604d736127f4
name: PYCR2
type: Species
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q96C36
is encoded by: hsa:29920

metaR RETH2e
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
product: MODEL1310110009#
name: retinyl ester hydrolase (11-cis), extracellular
type: Reaction
reversible: false

metaR OCCOAtx
reversible: true
kinetic law: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is described by: ECO:0000000
fast: false
product: MODEL1310110009#
is: SBO:0000185

metaM HC02217 c
name: prostaglandin-g2
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:27647
initial concentration: 1.0
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
is: SBO:0000247
constant: false

metaM ksi deg18 l
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:12936
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
name: keratan sulfate I, degradation product 18
initial concentration: 1.0
is: HMDB00143
has only substance units: false

metaR UDPGLCter
is: SBO:0000185
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
type: Reaction
reversible: true
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_e20f8c02_a368_4d66_a4a7_fdd93d2a1465
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
name: ADCY2
has only substance units: false
is encoded by: hsa:108
type: Species
is: Q71UM8

http://identifiers.org/biomodels.db/MODEL1310110009#_d22f6be9_1b32_4e90_bcd2_08a9ed239d23
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5860
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is: P09417
type: Species
name: QDPR

metaR RETHe
kinetic law: MODEL1310110009#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reversible: false
is: SBO:0000176
product: MODEL1310110009#
reactant: MODEL1310110009#
name: retinyl ester hydrolase, extracellular

metaM prostge1 e
is: CHEBI:57397
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: HMDB01442
is: SBO:0000247
name: prostaglandin E1(1-)
type: Species

metaR PI45PLC
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
fast: false
product: MODEL1310110009#
type: Reaction
modifier: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
is: SBO:0000176
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.1.4.11
reversible: false
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110009#_b40f50b6_63f3_4b94_8799_01140afe4ccc
is encoded by: hsa:48
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: ACO1
constant: false
is: P21399
boundary condition: true
type: Species

metaM pcrn x
name: propionyl-carnitine
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/107738
initial concentration: 1.0
is: HMDB00824
type: Species
constant: false
has only substance units: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_23694286_6721_4d20_94d8_47b8caf905f6
constant: false
is: SBO:0000252
is encoded by: hsa:AI915649
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
name: _AI915649_1_c
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_196dd020_0f3c_4d08_9a98_cf707164b5eb
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:2954
type: Species
name: GSTZ1
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR 3SPYRSP
name: 3-sulfinopyruvate hydrolase (spotaneous reaction)
fast: false
reversible: false
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
product: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_311180c5_a51e_40bb_a325_4afbd704105d
constant: false
is: P09923
initial concentration: NaN
name: ALPI
boundary condition: true
type: Species
is encoded by: hsa:248
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR HGNTOR
reversible: false
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.5
reactant: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110009#
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:

metaR MG3er
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
fast: false
reactant: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
product: MODEL1310110009#

metaM mal L m
is: CHEBI:15589
initial amount: NaN
initial concentration: 1.0
name: (S)-malate(2-)
is: HMDB00156
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
type: Species
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_f6345f08_a8e4_410e_b867_fb4d2cd2a5d0
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:2519
is: Q9BTY2
name: FUCA2
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_4d3b5193_e07d_49d4_bcd8_1df3b60aee49
constant: false
initial concentration: NaN
name: PYCRL
is: Q53H96
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:65263
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_3adb2c48_f1ef_4406_9f90_9ced50954019
boundary condition: true
is: P24539
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:515
has only substance units: false
name: ATP5F1
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_0f1e8e62_06d3_49e5_8327_a3ff491ba20c
name: CHAT
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q6LEN5
constant: false
is encoded by: hsa:1103

metaR RE1804C
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
type: Reaction
kinetic law: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
is: SBO:0000176
reversible: true
name: RE1804
reactant: MODEL1310110009#
fast: false

metaM HC02214 e
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
name: prostaglandin-f1alpha
boundary condition: false
is: CHEBI:28852
initial concentration: 1.0

metaM ksi pre21 g
is: HMDB00175
is: CHEBI:58053
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
initial amount: NaN
constant: false
is: C00130
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
name: keratan sulfate I biosynthesis, precursor 21
initial concentration: 1.0

metaR GK1
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.4.8
is described by: ECO:0000269
kinetic law: MODEL1310110009#
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
name: guanylate kinase (GMP:ATP)
product: MODEL1310110009#

metaM glysar e
is: SBO:0000247
name: Glycylsarcosine
type: Species
notes: FORMULA: C5H10N2O3 CHARGE: 0
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/93131
initial concentration: 1.0

metaM sT antigen g
name: sialyl-T antigen
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
notes: FORMULA: C25H40N2O18X CHARGE: -1
initial amount: NaN
is: SBO:0000247
is: CHEBI:16565
has only substance units: false

metaM dd2coa x
has only substance units: false
is: CHEBI:57330
type: Species
constant: false
is: HMDB03712
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
name: trans-Dodec-2-enoyl-CoA
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR DOLPMT4 Uer
is described by: ECO:0000000
is: SBO:0000185
reversible: false
product: MODEL1310110009#
kinetic law: MODEL1310110009#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
fast: false
reactant: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:

metaM cgly e
name: L-cysteinylglycine
type: Species
is: CHEBI:4047
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00078
boundary condition: false
has only substance units: false
constant: false

metaM hs deg23 l
has only substance units: false
notes: FORMULA: C31H49NO29S CHARGE: -2
is: HMDB02704
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:21338
type: Species
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
boundary condition: false
is: SBO:0000247

metaM cyan m
name: hydrogen cyanide
is: CHEBI:18407
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
has only substance units: false
initial amount: NaN
is: HMDB02084
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaM HC02187 c
initial amount: NaN
constant: false
is: CHEBI:28774
type: Species
name: reverse-triiodthyronine
is: SBO:0000247
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaM xylu L c
name: L-xylulose
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:17399
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
is: SBO:0000247
is: HMDB00751
has only substance units: false
boundary condition: false

metaR r0389
is described by: ECO:0000000
reactant: MODEL1310110009#
is: SBO:0000176
name: Pyridoxine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.1.3.12
kinetic law: MODEL1310110009#
reversible: true
product: MODEL1310110009#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.1.3.12 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:

metaR RE3346M
name: RE3346
fast: false
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (217.1) or (219.1) or (501.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.2.1.3

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_fecad716_cb1f_4d05_89b5_489101e45f33
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:134526
name: ACOT12
initial concentration: NaN
type: Species
is: Q5FWE9
constant: false
boundary condition: true
has only substance units: false

metaM glyc3p x
name: Glycerol 3-phosphate
is: HMDB00126
constant: false
boundary condition: false
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
has only substance units: false
initial concentration: 1.0
is: CHEBI:57597
type: Species
is: C00093
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_9d243e92_c8ee_4335_8399_d1ae13494e5d
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: PKM2
type: Species
is encoded by: hsa:5315

metaR HSD17B4x
is: SBO:0000176
kinetic law: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
is described by: ECO:0000269
modifier: MODEL1310110009#
reactant: MODEL1310110009#
name: hydroxysteroid (17-beta) dehydrogenase 4
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110009#

metaM 3pg m
is: SBO:0000247
constant: false
type: Species
is: HMDB00807
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
initial concentration: 1.0
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
is: CHEBI:58272
has only substance units: false

metaR RE0915E
modifier: MODEL1310110009#
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.17
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.1
is: SBO:0000176
name: RE0915
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:

metaM arab L c
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0
boundary condition: false
is: HMDB00646
is: SBO:0000247
is: CHEBI:30849
has only substance units: false
name: L-arabinose

http://identifiers.org/biomodels.db/MODEL1310110009#_0314dbd3_610f_4aec_822c_0d62acfb486f
name: GALT
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is: B4E097
boundary condition: true
type: Species
is encoded by: hsa:2592

metaM hs deg13 l
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: HMDB01352
is: SBO:0000247
is: CHEBI:17180
type: Species
boundary condition: false
name: heparan sulfate, degradation product 13

metaR EX c51crn
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

metaR RE1709N
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
product: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.96
reactant: MODEL1310110009#
reversible: true
name: RE1709
is described by: ECO:0000000
kinetic law: MODEL1310110009#

metaR LALDO2x
modifier: MODEL1310110009#
is described by: ECO:0000269
name: D-Lactaldehyde:NAD+ 1-oxidoreductase
is: SBO:0000176
type: Reaction
product: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: false
fast: false
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF

http://identifiers.org/biomodels.db/MODEL1310110009#_d2ab604f_957a_44fb_983a_6321317e361f
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
name: GUCY1B2
is encoded by: hsa:2974

metaM c81coa c
is: C05276
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
constant: false
has only substance units: false
type: Species
is: HMDB03949
name: octenoylcoa
is: SBO:0000247

metaM 3decdicoa m
name: 3,7-decadienoylcoa
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_fc61ef16_adc9_49d4_8159_6daae611bf2a
initial amount: NaN
is: P40926
constant: false
is: SBO:0000252
is encoded by: hsa:4191
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
name: MDH2

metaR r0388
name: Pyridoxamine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.4.3.5
kinetic law: MODEL1310110009#
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110009#

metaM cholp g
has only substance units: false
boundary condition: false
initial amount: NaN
is: C00588
initial concentration: 1.0
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
constant: false
is: SBO:0000247
is: CHEBI:295975
name: choline phosphate(1-)
type: Species

metaR DMNONCOACRNCPT1
is described by: ECO:0000000
name: DMNONCOACRNCPT1
product: MODEL1310110009#
is: SBO:0000176
kinetic law: MODEL1310110009#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
reactant: MODEL1310110009#
type: Reaction

metaM 6thf e
initial concentration: 1.0
name: hexaglutamyl folate (THF)
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/169691
type: Species
boundary condition: false
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
constant: false

metaR KSII CORE2tly
is: SBO:0000185
type: Reaction
reversible: false
name: keratan sulfate II (core 2) transport, extracellular to lysosome
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#

metaM trdox c
boundary condition: false
constant: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
name: Oxidized thioredoxin
is: C00343
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:18191
type: Species
initial amount: NaN

metaR ACACT1r
is described by: ECO:0000000
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
fast: false
name: acetyl-CoA C-acetyltransferase
product: MODEL1310110009#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: true
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
modifier: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_8c9c2009_e153_42da_ad5a_27027215d5c7
name: _J03866_1_m
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:J03866

http://identifiers.org/biomodels.db/MODEL1310110009#_7bcf2882_20f6_4eb0_baf8_5f14a4377375
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:10678
is: Q9NY97
has only substance units: false
name: B3GNT2
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_8598929d_a2b9_46a0_89a5_02223d46b9e9
name: _MBOAT5_1_c
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:MBOAT5

metaM HC02187 e
is: CHEBI:28774
name: reverse-triiodthyronine
initial amount: NaN
type: Species
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
is: SBO:0000247
initial concentration: 1.0

metaM m2mpdol U c
type: Species
initial amount: NaN
notes: FORMULA: C1365H2240N20O320P20 CHARGE: -20
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
constant: false
is: CHEBI:28049
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM glyc R m
has only substance units: false
constant: false
name: D-glycerate
is: HMDB00139
type: Species
boundary condition: false
is: CHEBI:16659
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
initial amount: NaN

metaR GAMt1r
is described by: ECO:0000269
product: MODEL1310110009#
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110009#
name: glucosamine transport (uniport)
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
fast: false

metaR UMPK4n
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110009#
fast: false
type: Reaction
name: UMP kinase (GTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM pcrn m
constant: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
name: propionyl-carnitine
is: http://identifiers.org/pubchem.compound/107738
is: HMDB00824
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_a0453093_dcc0_4e85_8c99_0964685dfc59
initial amount: NaN
has only substance units: false
is encoded by: hsa:10050
is: SBO:0000252
is: Q9Y2C5
boundary condition: true
initial concentration: NaN
constant: false
type: Species
name: SLC17A4

metaM CE1939 e
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: spermidine monoaldehyde 1
is: CHEBI:36781
is: SBO:0000247
type: Species
constant: false
has only substance units: false
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-1-2-5-9-6-3-7-10/h7,9H,1-6,8H2/p+2 EHMN_ABBREVIATION: CE1939

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_b61b0f36_8f4a_4d28_a71d_d5054cfb121d
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: ECHS1
type: Species
is: SBO:0000252
is encoded by: hsa:1892
is: P30084
constant: false
boundary condition: true

metaR r0968
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110009#
product: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
is: SBO:0000185
name: Postulated transport reaction

metaM n2m2nmn l
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C50H84N4O36 CHARGE: 0
boundary condition: false
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
is: SBO:0000247
is: HMDB00939
is: CHEBI:16680
has only substance units: false

metaR FAOXC163x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_4cf938ce_648b_481e_aa66_fa258fd57e2f
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:518
initial concentration: NaN
boundary condition: true
has only substance units: false
name: ATP5G3

http://identifiers.org/biomodels.db/MODEL1310110009#_630808af_54ad_4cf5_98d3_d4a91c15ea9d
is encoded by: hsa:10455
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: ECI2
type: Species
has only substance units: false
is: O75521
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_17563706_5bd8_42f7_9c87_b7b28edf41d5
is encoded by: hsa:374907
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: B3GNT8

metaR FAOXC14C12x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_cf0086b1_0f82_4542_9e27_88fe64fe32df
has only substance units: false
is: SBO:0000252
name: _AI378339_1_m
type: Species
is encoded by: hsa:AI378339
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

metaR RE3301C
reactant: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
is: SBO:0000176
name: RE3301
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
product: MODEL1310110009#
fast: false
reversible: true
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.1.4.4

metaM crn r
is: CHEBI:16347
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
name: (R)-carnitine
is: HMDB00062
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_25ba01cb_768f_4f3d_ba7b_682f4bff00ce
has only substance units: false
constant: false
is encoded by: hsa:728226
initial concentration: NaN
name: _728226_1_e
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR UDPGALtg
is described by: ECO:0000269
fast: false
name: UDP-Gal Golgi transport via CMP antiport
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
product: MODEL1310110009#
is: SBO:0000185
type: Reaction
reversible: true
modifier: MODEL1310110009#

metaR G16MT U
fast: false
kinetic law: MODEL1310110009#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110009#
name: Glycolipid 1,6-alpha-D-mannosyltransferase (uterus)

http://identifiers.org/biomodels.db/MODEL1310110009#_6320c34a_2424_4f89_ac86_d03cdd8dc60c
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:80025
constant: false
boundary condition: true
name: PANK2

metaR PRISTtx
fast: false
is described by: ECO:0000000
product: MODEL1310110009#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
name: prist peroxisomal transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ

metaR r0384
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
fast: false
is: SBO:0000176
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
product: MODEL1310110009#
type: Reaction
reversible: false
kinetic law: MODEL1310110009#
is described by: ECO:0000000

metaR DOLPMT4 Ler
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110009#
product: MODEL1310110009#

metaR AG13T1g
product: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
type: Reaction
modifier: MODEL1310110009#

metaR HDD2COAtx
type: Reaction
kinetic law: MODEL1310110009#
reversible: true
product: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
fast: false
reactant: MODEL1310110009#
name: hdd2coa intracellular transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110009#_b6a76faa_84eb_4886_81f2_1f2e06df2985
name: PECR
has only substance units: false
is encoded by: hsa:55825
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q9BY49
initial amount: NaN
constant: false

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaM gluala e
initial amount: NaN
is: C03740
constant: false
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
type: Species
is: http://identifiers.org/pubchem.compound/6503
is: HMDB06248
initial concentration: 1.0
boundary condition: false
name: 5-L-Glutamyl-L-alanine
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_1306b998_2b8f_4494_83ce_f54b67e02bb0
is encoded by: hsa:762
name: CA4
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q6FHI7
type: Species
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_bbb19b90_4918_4bb2_9c4a_a9dbaf2d041e
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:954
is: Q5SPY7
type: Species
boundary condition: true
name: ENTPD2
initial concentration: NaN

metaR HSAT2ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
product: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reversible: false
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110009#_241df74f_2add_421d_8548_6d588f43a8bb
has only substance units: false
type: Species
is encoded by: hsa:8560
initial amount: NaN
name: DEGS1
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN

metaM cholp c
is: SBO:0000247
type: Species
name: choline phosphate(1-)
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
is: CHEBI:295975
has only substance units: false
constant: false

metaR G14T14g
reactant: MODEL1310110009#
product: MODEL1310110009#
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176

metaR r1487
fast: false
product: MODEL1310110009#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110009#
is: SBO:0000176
reactant: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
name: EC:6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110009#_133916b0_915c_41b4_bc9f_77bbb2013a77
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: SLC25A21
constant: false
is encoded by: hsa:89874
is: G3V4L5
has only substance units: false
is: SBO:0000252
type: Species

metaM ksii core4 pre1 g
constant: false
name: keratan sulfate II biosynthesis, precursor 1
is: CHEBI:28067
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C36H60N3O25X CHARGE: 0
type: Species
boundary condition: false

metaR DOLPMT1 Uer
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.258
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
reactant: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110009#_d89988ea_a2ad_4bc8_95aa_968e947f0894
is: Q9NP56
has only substance units: false
boundary condition: true
is encoded by: hsa:27115
constant: false
initial amount: NaN
name: PDE7B
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_d9440ff6_000f_41b1_b83f_0d0a85c74040
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
name: ALDH3B1
is encoded by: hsa:221
boundary condition: true
is: P43353

metaM 34dhphe e
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:15765
is: HMDB00181
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
name: L-dopa
has only substance units: false

metaR C100CPT1
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decanoylcarnitine
type: Reaction

metaR EX CE5869 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lysyl-proline exchange
type: Reaction

metaM glyb c
is: CHEBI:17750
constant: false
type: Species
name: glycine betaine
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: HMDB00043
is: SBO:0000247
initial amount: NaN

metaM accoa g
name: acetyl-CoA(4-)
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false
is: HMDB01206
is: CHEBI:57288
type: Species

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaR CERT1rt
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000304
reversible: true
fast: false
reactant: MODEL1310110009#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
name: ceramide transport protein
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide

metaM HC01609 e
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
is: CHEBI:28766
name: UroporphyrinogenI
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false

metaM mal L e
initial concentration: 1.0
is: HMDB00156
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
name: (S)-malate(2-)
is: CHEBI:15589
constant: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
is: SBO:0000247

metaR C50CPT1
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of isovalerylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_1f39efa1_dad6_42dd_95d6_3e0bf24be841
is encoded by: hsa:23632
type: Species
is: A8K3J4
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: CA14
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_2e22db0d_2e8a_4808_a81f_b20b5642d651
name: ACAA1:HSD17B4:ACOX1
is: SBO:0000297
boundary condition: true
type: Species
is encoded by: hsa:3295
has part: E9PB82
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_b209f629_5291_4e37_9f3a_5ae54523f776
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: O60760
has only substance units: false
name: HPGDS
is encoded by: hsa:27306
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_9e391aac_0928_4c02_87a3_c0f957f43d06
is: SBO:0000252
is: Q8TB61
initial concentration: NaN
boundary condition: true
name: SLC35B2
constant: false
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:347734

http://identifiers.org/biomodels.db/MODEL1310110009#_5a9d8859_31e8_42a0_9c77_cd01b7337a3f
initial concentration: NaN
boundary condition: true
constant: false
name: B4GALT1
type: Species
initial amount: NaN
is encoded by: hsa:2683
is: SBO:0000252
has only substance units: false
is: P15291

http://identifiers.org/biomodels.db/MODEL1310110009#_ca15db31_b58c_4e73_8cbd_ecb9d01adb7e
boundary condition: true
name: SLC32A1
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:140679
is: Q9H598
has only substance units: false
is: SBO:0000252
type: Species

metaR D3AIBTm
type: Reaction
is: SBO:0000176
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
is described by: ECO:0000000
fast: false
product: MODEL1310110009#
reversible: true

metaR FAOXC81C61m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

metaM 4hexdtricoa m
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
name: 4,7,10-hexadecatrienoylcoa
is: HMDB02288
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_fe309b98_4149_415e_8a9c_27515bd9f940
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:60490
is: Q96CD2
name: PPCDC
type: Species
boundary condition: true

metaR r0381
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110009#
is: SBO:0000176
reactant: MODEL1310110009#
product: MODEL1310110009#
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_7f904eb0_1827_40b4_bedb_6d130ba76917
is: Q9Y2A9
constant: false
has only substance units: false
name: B3GNT3
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:10331

metaM pydam c
initial amount: NaN
initial concentration: 1.0
is: HMDB01431
has only substance units: false
type: Species
is: CHEBI:57761
is: C00534
name: Pyridoxamine
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534

http://identifiers.org/biomodels.db/MODEL1310110009#_50166c31_1006_4bf3_9555_13ec654ceca7
constant: false
initial concentration: NaN
initial amount: NaN
is: P49753
is encoded by: hsa:10965
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
name: ACOT2

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaM adrncoa x
is: http://identifiers.org/pubchem.compound/47205480
initial concentration: 1.0
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
is: C16170
name: adrenyl coenzyme A
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_203143d0_e8b0_44ec_9786_7a7193478eb4
constant: false
is encoded by: hsa:129642
name: MBOAT2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q6ZWT7
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_5cf5e7bf_82b3_4cdc_9984_b4b032220a36
name: PDE9A
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5152
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_4139dc94_fa36_427a_9d6e_2a9e6e36d855
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q9H2F3
type: Species
is encoded by: hsa:80270
name: HSD3B7
constant: false
initial amount: NaN
boundary condition: true

metaR RE1804M
product: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
name: RE1804
type: Reaction
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: true
fast: false
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000000

metaR ACGALtly
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
name: N-acetyl-galactosamine lysosomal efflux
type: Reaction
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
is: SBO:0000185
fast: false
reversible: false

metaM succoa c
type: Species
is: HMDB01022
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: Succinyl-CoA

metaR DHFR
reversible: true
reactant: MODEL1310110009#
product: MODEL1310110009#
name: dihydrofolate reductase
fast: false
modifier: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
is described by: ECO:0000254
type: Reaction
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.5.1.3

metaR r0963
is: SBO:0000185
fast: false
reactant: MODEL1310110009#
reversible: false
type: Reaction
name: Facilitated diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
product: MODEL1310110009#

metaR M4MPDOL Uter
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110009#
name: m4mpdol flippase
type: Reaction
fast: false

metaR r1464
product: MODEL1310110009#
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
name: Active transport
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_85d76b93_cefd_438b_b322_20b2ad95fa6d
is encoded by: hsa:10873
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: Q6TCH8
name: ME3
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_3818bdd1_d5dc_4c89_aa26_4b77738654ee
type: Species
initial amount: NaN
is encoded by: hsa:6582
boundary condition: true
is: SBO:0000252
name: SLC22A2
constant: false
has only substance units: false
initial concentration: NaN

metaR GLCAASE9ly
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction
name: beta-glucuronidase, lysosomal
reactant: MODEL1310110009#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
reversible: false
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
fast: false
product: MODEL1310110009#

metaR RPEc
is: SBO:0000176
fast: false
reactant: MODEL1310110009#
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
product: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: true
name: ribulose 5-phosphate 3-epimerase

metaM glyb e
is: CHEBI:17750
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
constant: false
name: glycine betaine
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00043

metaM HC01842 c
name: Phosphodimethylethanolamine
is: CHEBI:31997
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
type: Species
boundary condition: false
initial amount: NaN
constant: false

metaR S6T14g
reactant: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
reversible: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110009#
modifier: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_1001a4fd_e284_4d28_b387_44d690b27ef7
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:3141
has only substance units: false
is: P50747
name: HLCS

http://identifiers.org/biomodels.db/MODEL1310110009#_bfb3dbad_951b_40aa_ae93_703a3c47f7b9
name: GALNT6
initial amount: NaN
is encoded by: hsa:11226
boundary condition: true
type: Species
is: Q8NCL4
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN

metaM 3pg c
is: SBO:0000247
initial concentration: 1.0
is: C00197
is: CHEBI:58272
is: HMDB00807
is: http://identifiers.org/pubchem.compound/3497
type: Species
boundary condition: false
constant: false
name: 3-Phospho-D-glycerate
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_a9fb6643_2815_41ea_99f6_ee4f27e8954d
is: SBO:0000252
name: ATIC
is encoded by: hsa:471
boundary condition: true
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is: P31939

metaM crn x
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false
type: Species
name: L-Carnitine
is: SBO:0000247
initial amount: NaN
is: C00318
has only substance units: false
is: CHEBI:16347
is: HMDB00062
initial concentration: 1.0
constant: false

metaR ATPH2e
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.6.1.6
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
name: ATP diphosphohydrolase
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (954.2) or (954.1) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT

metaM mal L c
initial concentration: 1.0
type: Species
constant: false
name: (S)-malate(2-)
is: HMDB00156
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: SBO:0000247
is: CHEBI:15589
initial amount: NaN
boundary condition: false
has only substance units: false

metaR r0962
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
reversible: false
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Facilitated diffusion
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110009#_b976b837_12af_4262_8807_6c590c3882dc
type: Species
is: P00533
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
name: EGFR
is: SBO:0000252
is encoded by: hsa:1956
initial amount: NaN

metaR RE1530C
name: RE1530
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reversible: true
product: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
is: SBO:0000176
fast: false
type: Reaction

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_729e8969_164e_4d08_a086_d00d285457a8
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:2544
boundary condition: true
initial concentration: NaN
name: _2544_1_c

metaM glygn5 e
name: glycogen, structure 5 (glycogenin-2[1,4-Glc])
initial concentration: 1.0
notes: FORMULA: C12H21O11X CHARGE: 0
is: CHEBI:33871
constant: false
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB06372
has only substance units: false
initial amount: NaN

metaM ca2 e
boundary condition: false
is: HMDB00464
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
name: calcium(2+)
initial amount: NaN
constant: false
is: CHEBI:29108
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_40e7c96b_7f30_4a8d_a135_20c9cff16403
constant: false
is: SBO:0000252
is: Q9C0J1
is encoded by: hsa:79369
has only substance units: false
initial amount: NaN
boundary condition: true
name: B3GNT4
type: Species
initial concentration: NaN

metaR RETI2
is described by: ECO:0000000
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
reactant: MODEL1310110009#
reversible: true
product: MODEL1310110009#
name: retinol isomerase (9-cis)
type: Reaction
fast: false

metaM hs deg5 l
is: HMDB00158
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:17895
name: heparan sulfate, degradation product 5
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C67H97N4O86S10 CHARGE: -11

metaR r0639
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000000
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
product: MODEL1310110009#
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#

metaM andrstrn r
is: HMDB00031
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: androsterone
initial amount: NaN
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
is: CHEBI:16032
boundary condition: false
constant: false

metaM mpdol U c
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:18396
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C1245H2040N20O220P20 CHARGE: -20
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog

metaM glyc R c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16659
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
name: D-glycerate
type: Species
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: HMDB00139

metaM galside hs c
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: CHEBI:12947
name: D-galactosyl-N-acylsphingosine

metaR RETI1
is: SBO:0000176
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
reversible: true
name: retinol isomerase (11-cis)
product: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
is described by: ECO:0000000

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaR FAOXC81C61x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_bbc4ef8d_2f8a_44ca_ac35_53e84b706541
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
name: TXNRD1
type: Species
is encoded by: hsa:7296
initial amount: NaN

metaR H2MTer L
fast: false
modifier: MODEL1310110009#
is: SBO:0000176
reactant: MODEL1310110009#
reversible: false
name: H2 mannosyltransferase, endoplasmic reticulum
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD

metaM accoa r
is: SBO:0000247
type: Species
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: CHEBI:57288
name: acetyl-CoA(4-)
is: HMDB01206
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false

metaR HIBDm
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.31
reversible: true
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000176
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
fast: false
modifier: MODEL1310110009#

metaR 2MB2COAc
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 2-methylcrotonoyl-CoA into cytosol
type: Reaction

metaR INSt4
reactant: MODEL1310110009#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (9153.1) or (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:MM
type: Reaction
fast: false
product: MODEL1310110009#
is: SBO:0000185
modifier: MODEL1310110009#
name: inosine transport in via sodium symport

metaR RE0453C
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
name: RE0453
reactant: MODEL1310110009#
product: MODEL1310110009#
fast: false
is: SBO:0000176
type: Reaction
reversible: true
kinetic law: MODEL1310110009#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_1e17d774_7479_470c_9a61_51530ba6cc92
initial amount: NaN
name: GALNT5
is encoded by: hsa:11227
boundary condition: true
is: A5PKZ1
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR S6TASE16ly
modifier: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110009#
reversible: true
is described by: ECO:0000000
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_7df25626_c09b_45e4_a130_a99eeea606ab
is encoded by: hsa:79053
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
name: ALG8

metaR NDPK1m
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
is: SBO:0000176
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
type: Reaction
fast: false
is described by: ECO:0000254
reactant: MODEL1310110009#
modifier: MODEL1310110009#
product: MODEL1310110009#

metaR L LACt4r
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
reversible: true
type: Reaction
name: L-lactate reversible transport via sodium symport
product: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110009#_969f57ac_a33a_490c_847a_b51272289ec2
constant: false
boundary condition: true
is: P30048
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
name: PRDX3
is encoded by: hsa:10935
initial amount: NaN

metaR RE3244R
is: SBO:0000176
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110009#
name: RE3244
is described by: ECO:0000000
kinetic law: MODEL1310110009#
product: MODEL1310110009#
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:

metaM pcrn c
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/107738
boundary condition: false
is: HMDB00824
name: propionyl-carnitine
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3

metaR NACHEX21ly
is: SBO:0000176
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110009#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.52

metaM 4hexdtricoa x
initial concentration: 1.0
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
boundary condition: false
type: Species
initial amount: NaN
constant: false
name: 4,7,10-hexadecatrienoylcoa
is: HMDB02288
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_8de11b6d_eb17_4fcf_8370_471b71bd319a
initial amount: NaN
name: PLCB1
boundary condition: true
type: Species
has only substance units: false
constant: false
is encoded by: hsa:23236
initial concentration: NaN
is: SBO:0000252

metaM pyr e
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15361
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
boundary condition: false
name: pyruvate
has only substance units: false
is: SBO:0000247
is: HMDB00243
constant: false

metaR RE1845X
is described by: ECO:0000000
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
name: RE1845
product: MODEL1310110009#
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
fast: false
modifier: MODEL1310110009#
is: SBO:0000176

metaM 34dhphe c
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
boundary condition: false
is: HMDB00181
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:15765
name: L-dopa

metaM cs e deg3 l
is: HMDB00127
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C37H53NO44S4 CHARGE: -6
is: CHEBI:15748
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
initial concentration: 1.0

metaR RETI3
kinetic law: MODEL1310110009#
is: SBO:0000176
reactant: MODEL1310110009#
reversible: true
product: MODEL1310110009#
name: retinol isomerase (13-cis)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 4 AUTHORS: PMID:11606944 NOTES:IT
type: Reaction
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_4eb86a01_295d_4eef_bc5f_08c31278dee6
boundary condition: true
name: ETFA:ETFB
has only substance units: false
type: Species
is: SBO:0000297
has part: P38117
initial amount: NaN
constant: false
is encoded by: hsa:2109
initial concentration: NaN

metaR NDPK1n
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110009#
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
modifier: MODEL1310110009#
reactant: MODEL1310110009#

metaR CHSTEROLtrc
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: true
is described by: ECO:0000134
product: MODEL1310110009#
name: transport of cholesterol into the cytosol
type: Reaction
is: SBO:0000185
fast: false

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaR APOCFm
is: SBO:0000176
kinetic law: MODEL1310110009#
reversible: false
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
name: Apocarboxylase formation, mitochondrial
fast: false
type: Reaction
reactant: MODEL1310110009#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_223e1fbf_bc00_4fc1_834d_1d03ec361cb9
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: O60909
is: SBO:0000252
initial concentration: NaN
name: B4GALT2
constant: false
is encoded by: hsa:8704

metaM acgam6p c
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57513
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
initial amount: NaN
has only substance units: false
type: Species
name: N-acetyl-D-glucosamine 6-phosphate(2-)
is: HMDB01062
boundary condition: false

metaM dd2coa c
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: HMDB03712
name: trans-Dodec-2-enoyl-CoA
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_b6438f31_b04b_4f0c_8c39_3cefe2a75444
constant: false
is encoded by: hsa:AI024818
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
name: _AI024818_1_c
initial amount: NaN

metaM 2mp2coa m
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27754
name: 2-Methylprop-2-enoyl-CoA
is: SBO:0000247
is: HMDB01011
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
has only substance units: false

metaM dcsptn1crn m
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB06321
constant: false
name: docosa-4,7,10,13,16-pentaenoyl carnitine
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
initial concentration: 1.0

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

metaR r0522
product: MODEL1310110009#
fast: false
is: SBO:0000176
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
modifier: MODEL1310110009#

metaM prostge2 e
initial concentration: 1.0
boundary condition: false
name: prostaglandin E2(1-)
is: CHEBI:606564
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
constant: false
type: Species
is: HMDB01220
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM hs deg7 l
type: Species
is: CHEBI:17180
initial amount: NaN
name: heparan sulfate, degradation product 7
boundary condition: false
is: HMDB01352
is: SBO:0000247
constant: false
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
initial concentration: 1.0
has only substance units: false

metaR EX gumtchol LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for guar gum-taurocholic acid complex
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_f7965364_3f76_4a95_9853_7f96079e7004
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: ELOVL2
boundary condition: true
has only substance units: false
is: Q9NXB9
is encoded by: hsa:54898

metaM formcoa x
type: Species
is: HMDB03419
name: formyl-CoA(4-)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57376

metaM pyr c
name: pyruvate
is: SBO:0000247
is: CHEBI:15361
initial amount: NaN
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1
is: HMDB00243
constant: false
is: http://identifiers.org/pubchem.compound/3324
boundary condition: false
is: C00022
initial concentration: 1.0
has only substance units: false

metaR GASNASE3ly
name: glycosylasparaginase, lysosomal
type: Reaction
is: SBO:0000176
modifier: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.26
reversible: false
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
fast: false
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#

metaR r1600
is described by: ECO:0000000
product: MODEL1310110009#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction

metaR DAGKn hs
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (8525.1) or (9162.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
name: Diacylglycerol phosphate kinase (homo sapiens)
is version of: http://identifiers.org/ec-code/2.7.1.107
is described by: ECO:0000269
kinetic law: MODEL1310110009#
type: Reaction

metaM trp L e
has only substance units: false
is: CHEBI:16828
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
name: L-tryptophan
type: Species
is: HMDB00929
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM galside hs g
has only substance units: false
is: CHEBI:12947
initial concentration: 1.0
is: SBO:0000247
name: D-galactosyl-N-acylsphingosine
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
boundary condition: false

metaM ksi deg23 l
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate I, degradation product 23
is: HMDB00143
is: CHEBI:12936
boundary condition: false

metaM 3hpcoa m
initial amount: NaN
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
constant: false
initial concentration: 1.0
is: HMDB06807
is: SBO:0000247
name: 3-hydroxypropanoyl-CoA(4-)
is: CHEBI:58528
boundary condition: false
type: Species
has only substance units: false

metaR r0523
reversible: false
is: SBO:0000176
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110009#
fast: false
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
modifier: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_0303b0de_1945_4359_a43c_bed493e68cd5
initial concentration: NaN
name: G6PC3
type: Species
is: Q9BUM1
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:92579

http://identifiers.org/biomodels.db/MODEL1310110009#_5e501053_2758_4b95_82c2_2c12955681e7
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:223
is: P49189
name: ALDH9A1
has only substance units: false
constant: false
boundary condition: true
type: Species
initial concentration: NaN

metaR r0636
reversible: false
name: Octanoyl-CoA:L-carnitine O-octanoyltransferase EC:2.3.1.137
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.137 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
modifier: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000176

metaR ADSK
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
modifier: MODEL1310110009#
is: SBO:0000176
name: adenylyl-sulfate kinase
type: Reaction
fast: false
reversible: false
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.1.25
is described by: ECO:0000269
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#

metaR INSTt4 2
name: inositol transport via sodium symport
modifier: MODEL1310110009#
is: SBO:0000185
product: MODEL1310110009#
fast: false
reversible: true
is described by: ECO:0000006
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
reactant: MODEL1310110009#

metaM met L c
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: L-methionine
type: Species
is: HMDB00696
is: CHEBI:16643
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
constant: false

metaR G6PDH1rer
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.47
is: SBO:0000176
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
kinetic law: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110009#
product: MODEL1310110009#

metaM accoa n
initial amount: NaN
name: acetyl-CoA(4-)
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species
is: HMDB01206
is: CHEBI:57288
constant: false
is: SBO:0000247

metaR r0637
product: MODEL1310110009#
fast: false
is described by: ECO:0000000
type: Reaction
name: Octanoyl-CoA:L-carnitine O-octanoyltransferase EC:2.3.1.137
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.137 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000176
reversible: false

metaR ACNAMPH
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false
is: SBO:0000176
reactant: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000000
name: N-Acetylneuraminate 9-phosphate phosphohydrolase
fast: false
kinetic law: MODEL1310110009#

metaM hs deg24 l
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C31H50NO26 CHARGE: -1
name: GlcNAc-GlcA-(Gal)2-Xyl
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16126

metaM ca2 c
type: Species
is: HMDB00464
name: calcium(2+)
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:29108
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR r1602
kinetic law: MODEL1310110009#
is: SBO:0000185
product: MODEL1310110009#
fast: false
reversible: true
reactant: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000

metaM trp L c
is: SBO:0000247
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: CHEBI:16828
name: L-tryptophan
type: Species
is: HMDB00929
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false

metaM dgdp m
is: HMDB00960
is: CHEBI:58595
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
name: dGDP(2-)

metaR LYStip
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
fast: false
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
type: Reaction
product: MODEL1310110009#
name: L-lysine transport, peroxisomal (irreversible)

metaM cholcoar x
has only substance units: false
initial amount: NaN
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
constant: false
initial concentration: 1.0
is: CHEBI:58677
is: HMDB02178
type: Species
boundary condition: false
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
is: SBO:0000247

metaR PDE4n
modifier: MODEL1310110009#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110009#
name: 3',5'-cyclic-nucleotide phosphodiesterase, Nucleus
notes: GENE_ASSOCIATION: (5152.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:12565835,PMID:14527714,PMID:9624146 NOTES:NCD. IT
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.1.4.35
reversible: false
product: MODEL1310110009#
fast: false

metaM accoa m
constant: false
is: SBO:0000247
is: CHEBI:57288
initial amount: NaN
has only substance units: false
type: Species
is: C00024
is: HMDB01206
name: Acetyl-CoA
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024

http://identifiers.org/biomodels.db/MODEL1310110009#_643e762f_7fea_4081_910b_7f3a60ffd40a
is: B3KVA3
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:112724
constant: false
has only substance units: false
boundary condition: true
type: Species
name: RDH13

metaM HC00591 c
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: 2-oxoglutaramate
is: CHEBI:16769
type: Species

metaR r0638
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000176
modifier: MODEL1310110009#
product: MODEL1310110009#
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is version of: http://identifiers.org/ec-code/2.8.1.2

metaR LNLNCAt
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
product: MODEL1310110009#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_6a07b786_c764_44bd_b64e_e1cb9bbaae1f
type: Species
is encoded by: hsa:4967
boundary condition: true
name: OGDH
constant: false
is: SBO:0000252
is: B4E3E9
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM dgdp n
has only substance units: false
is: SBO:0000247
constant: false
type: Species
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: HMDB00960
is: CHEBI:58595
initial concentration: 1.0
initial amount: NaN
name: dGDP(2-)

metaR r0236
reactant: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
reversible: true
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.5.1.6
is described by: ECO:0000000
fast: false
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
product: MODEL1310110009#
is: SBO:0000176

metaM met L e
is: HMDB00696
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
initial concentration: 1.0
is: CHEBI:16643
is: SBO:0000247
name: L-methionine
boundary condition: false
has only substance units: false

metaR IVCRNe
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of isovaleryl carnitine into the extra cellular space
type: Reaction

metaR SIAASE4ly
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
name: sialidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110009#
fast: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110009#

metaR DTTPtn
is: SBO:0000185
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: dTTP diffusion in nucleus
kinetic law: MODEL1310110009#
type: Reaction
fast: false
reversible: true
product: MODEL1310110009#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_c6d2a132_1eac_41ea_b8ed_c30cc88fca91
name: EHHADH:ACAA1:ACOX1
type: Species
initial amount: NaN
is encoded by: hsa:1962
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000297
has part: Q9NY65
initial concentration: NaN

metaM ocde9ecoa x
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/5280355
name: 9-octadecenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110009#_3229346a_277b_4b46_bd57_9061edff8ec8
is: Q8IV97
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:8140
name: SLC7A5
initial amount: NaN
constant: false
is: SBO:0000252

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaM adrncoa c
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205480
type: Species
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
initial amount: NaN
initial concentration: 1.0
name: adrenyl coenzyme A
constant: false
boundary condition: false
is: C16170

metaM dgdp c
type: Species
is: SBO:0000247
name: dGDP
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: C00361
boundary condition: false
is: HMDB00960
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:58595

metaR r1604
is described by: ECO:0000000
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_95eaca24_e4af_4b95_acab_3a7f3e42fc1d
initial concentration: NaN
is: Q8IZH9
constant: false
type: Species
is encoded by: hsa:2643
initial amount: NaN
boundary condition: true
name: GCH1
is: SBO:0000252
has only substance units: false

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_173a52e6_de9a_49f4_8dfc_765d9e8c5ab9
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is: Q9NRF8
has only substance units: false
name: CTPS2
is encoded by: hsa:56474
type: Species

metaR r2433
product: MODEL1310110009#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_5e27b5b4_bfd9_4190_881c_1a2c7fd7253d
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5332
is: E2QRH8
constant: false
type: Species
name: PLCB4
boundary condition: true
initial concentration: NaN

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaM gam6p c
is: CHEBI:12962
name: D-Glucosamine 6-phosphate
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
is: HMDB01254
initial amount: NaN
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_dd55d75b_3a19_4207_ad23_70fdd568282a
is encoded by: hsa:1375
boundary condition: true
is: SBO:0000252
constant: false
is: Q92523
initial amount: NaN
name: CPT1B
has only substance units: false
initial concentration: NaN
type: Species

metaM dd2coa m
is: CHEBI:57330
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
name: trans-dodec-2-enoyl-CoA(4-)
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: HMDB03712

http://identifiers.org/biomodels.db/MODEL1310110009#_a18497f0_57b8_49e2_9d02_6d633a9be46a
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:51
name: ACOX1
initial concentration: NaN
is: SBO:0000252
is: B4DK61
type: Species

metaM CE4793 x
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
name: 3-oxo-dihomo-gama-linolenoyl-CoA
initial concentration: 1.0
notes: FORMULA: C41H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29(49)24-32(51)70-23-22-43-31(50)20-21-44-39(54)36(53)41(2,3)26-63-69(60,61)66-68(58,59)62-25-30-35(65-67(55,56)57)34(52)40(64-30)48-28-47-33-37(42)45-27-46-38(33)48/h8-9,11-12,14-15,27-28,30,34-36,40,52-53H,4-7,10,13,16-26H2,1-3H3,(H,43,50)(H,44,54)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/b9-8-,12-11-,15-14-/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4793
type: Species
is: CHEBI:57923

metaM ksi pre18 g
notes: FORMULA: C163H262N11O132S5X CHARGE: -6
name: keratan sulfate I biosynthesis, precursor 18
constant: false
is: C00130
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00175
initial concentration: 1.0
is: CHEBI:58053

metaR RE3346C
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
fast: false
reactant: MODEL1310110009#
is: SBO:0000176
modifier: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110009#
name: RE3346
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM phyt c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
initial amount: NaN
is: HMDB00801
has only substance units: false
constant: false
is: CHEBI:37257
type: Species
name: phytanate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_6510dae9_995b_48c3_a597_7cadf40809dd
boundary condition: true
is: Q8NFF2
type: Species
is: SBO:0000252
initial concentration: NaN
name: SLC24A4
has only substance units: false
initial amount: NaN
is encoded by: hsa:123041
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_211f0a80_46d9_4c66_b901_4d034773a54b
is encoded by: hsa:27034
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: ACAD8
is: Q6ZWP6
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR r1603
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r2434
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
reversible: false
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110009#
is: SBO:0000185
kinetic law: MODEL1310110009#
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_66f24f7c_7195_45b1_9d4d_0c501f817416
constant: false
is encoded by: hsa:3938
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: P09848
is: SBO:0000252
name: LCT

http://identifiers.org/biomodels.db/MODEL1310110009#_89e59c7b_8143_4485_bd9c_36eb88e5ed92
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
name: _AF116616_1_m
constant: false
initial amount: NaN
is encoded by: hsa:AF116616

metaR MCLACCYSR
fast: false
kinetic law: MODEL1310110009#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110009#
name: 3-mercaptolactate:cysteine reductase
reactant: MODEL1310110009#

metaM nad x
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3305
type: Species
is: CHEBI:57540
is: C00003
has only substance units: false
boundary condition: false
initial amount: NaN
name: Nicotinamide adenine dinucleotide
is: HMDB00902
is: SBO:0000247

metaR r0527
kinetic law: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
reversible: true
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_fd3509a8_593e_4152_98a0_b07bbd520d71
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:1809
initial concentration: NaN
is: Q8IXW6
boundary condition: true
name: DPYSL3

http://identifiers.org/biomodels.db/MODEL1310110009#_558af3b3_0a15_4e46_bfc7_e7a8034c9e4b
is: Q5FC00
is encoded by: hsa:765
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: CA6
boundary condition: true
constant: false

metaR RE0453N
type: Reaction
modifier: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
reactant: MODEL1310110009#
fast: false
reversible: true
name: RE0453
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110009#_2652f909_0a82_489b_95ac_7cf4d5c54087
is encoded by: hsa:9197
constant: false
is: O00400
boundary condition: true
is: SBO:0000252
name: SLC33A1
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species

metaR ETFQO
kinetic law: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
product: MODEL1310110009#
reactant: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000176
type: Reaction
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
is version of: http://identifiers.org/ec-code/1.5.5.1
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_1e5dbede_80fb_4311_8030_43cbd4ee8880
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: AKR1C4
is: P17516
type: Species
boundary condition: true
is encoded by: hsa:1109
constant: false

metaR r1606
reactant: MODEL1310110009#
reversible: true
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_05c6d3c2_112d_4619_af66_70ffa3bcbdbb
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:123041
name: SLC24A4

metaM Lcystin e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
initial amount: NaN
is: HMDB00192
type: Species
name: L-cystine
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:16283

metaR r0633
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176
product: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.3
fast: false
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110009#_b314f64d_7283_432f_bc67_091f4343f020
is: P47989
is encoded by: hsa:7498
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
name: XDH
type: Species
is: SBO:0000252
initial concentration: NaN

metaM phyt e
initial amount: NaN
initial concentration: 1.0
is: HMDB00801
constant: false
boundary condition: false
is: CHEBI:37257
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
type: Species
has only substance units: false
is: SBO:0000247
name: phytanate

metaR r1762
name: Y+LAT2 Utilized transport
modifier: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110009#_fd185236_5b14_46cf_bb86_d220b865c321
is encoded by: hsa:55650
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: Q9NUD9
name: PIGV
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM dcsptn1crn c
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl carnitine
constant: false
is: HMDB06321
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_98a3c713_0786_4e21_ba0c_ff9b042f5ed0
is: Q8TBF5
name: PIGX
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:54965
constant: false
type: Species
initial concentration: NaN
has only substance units: false

metaM xoltetrol m
constant: false
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
is: SBO:0000247
is: CHEBI:17278
initial concentration: 1.0
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
is: HMDB01231
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN

metaR r1605
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110009#
reversible: true
product: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110009#_a97e22bb_3d1f_4e22_8b76_2faf0caf239e
constant: false
is: P26439
is: SBO:0000252
is encoded by: hsa:3284
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
name: HSD3B2

http://identifiers.org/biomodels.db/MODEL1310110009#_386bb61b_0759_43b0_9002_693c6abf7dcc
constant: false
initial amount: NaN
is: P56385
name: ATP5I
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:521

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR GLCNACASE1ly
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.50
type: Reaction
product: MODEL1310110009#
fast: false
is: SBO:0000176
name: alpha-N-acetylglucosaminidase, lysosomal
reactant: MODEL1310110009#
reversible: false

metaM accoa x
boundary condition: false
is: HMDB01206
initial concentration: 1.0
has only substance units: false
is: C00024
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:57288
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
name: Acetyl-CoA
type: Species

metaR r0634
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
modifier: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
reversible: true
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is version of: http://identifiers.org/ec-code/3.1.4.1
is: SBO:0000176
product: MODEL1310110009#
fast: false

metaM CE1940 e
constant: false
name: spermidine monoaldehyde 2
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB02329
has only substance units: false
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-3-6-9-5-1-2-7-10/h7,9H,1-6,8H2/p+1 EHMN_ABBREVIATION: CE1940
is: CHEBI:30623
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_23d897ed_51cf_4a37_977d_1f9b7f744132
constant: false
is encoded by: hsa:5277
name: PIGA
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: P37287
is: SBO:0000252
type: Species
has only substance units: false

metaR EX c16dc
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecanedioic acid mono-L-carnitine ester
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_721b072d_292c_4b64_8541_56494c5e0d2c
boundary condition: true
type: Species
name: _286297_1_c
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:286297
initial concentration: NaN
is: SBO:0000252

metaR EX ivcrn
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for isovaleryl carnitine
type: Reaction

metaM 3mb2coa m
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
is: SBO:0000247
is: CHEBI:57344
constant: false
name: 3-methylbut-2-enoyl-CoA(4-)
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB01493

metaM cyan e
is: CHEBI:18407
is: HMDB02084
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
name: hydrogen cyanide
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
boundary condition: false

metaR DIGALSIDEtl
type: Reaction
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is described by: ECO:0000000
kinetic law: MODEL1310110009#
reversible: true
name: digalside hs intracellular transport
is: SBO:0000185
product: MODEL1310110009#
fast: false

metaR HPACtr
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
reactant: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
reversible: true
type: Reaction
name: hydroxyphenylacetate transport via diffusion
product: MODEL1310110009#

metaM ksii core4 pre2 g
notes: FORMULA: C47H76N4O33X CHARGE: -1
is: C00130
constant: false
is: CHEBI:58053
initial concentration: 1.0
is: SBO:0000247
is: HMDB00175
type: Species
name: keratan sulfate II boisynthesis, precursor 2
boundary condition: false
has only substance units: false
initial amount: NaN

metaM Lcystin c
initial concentration: 1.0
is: CHEBI:16283
is: HMDB00192
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
initial amount: NaN
name: L-cystine
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
constant: false

metaR NACHEX18ly
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000176
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110009#

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaR r1608
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
type: Reaction
reversible: true
product: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110009#_04650771_c33d_4176_9f38_df0c24328cd7
is encoded by: hsa:151531
type: Species
constant: false
initial amount: NaN
is: O95045
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: UPP2

http://identifiers.org/biomodels.db/MODEL1310110009#_b9f31ecd_1bf3_47eb_98be_f6be750b281a
type: Species
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: Q8NCG5
initial amount: NaN
name: CHST4
is encoded by: hsa:10164
is: SBO:0000252

metaM Rtotal3coa c
boundary condition: false
is: CHEBI:16189
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
initial concentration: 1.0
name: R total 3 Coenzyme A
is: HMDB01448
initial amount: NaN
has only substance units: false

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaR BILDGLCURt
fast: false
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
type: Reaction
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_f3b4fe90_08db_408b_8345_c0f2edcc5c1f
is: E9KL48
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2746
type: Species
initial amount: NaN
is: SBO:0000252
name: GLUD1

metaM lald D c
constant: false
name: (R)-lactaldehyde
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:17167
initial concentration: 1.0
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
initial amount: NaN
is: HMDB06458
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_d8a4d705_052d_4a88_89b0_fbba82dff52e
initial concentration: NaN
initial amount: NaN
is: P22102
name: GART
is encoded by: hsa:2618
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_2fcea9c4_63b7_42f0_b658_aaa73d691931
is: Q6GTM5
type: Species
is: SBO:0000252
has only substance units: false
name: SC5DL
initial amount: NaN
constant: false
is encoded by: hsa:6309
initial concentration: NaN
boundary condition: true

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaM HC00591 m
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:16769
name: 2-oxoglutaramate
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_7c77b296_dcc3_44ee_afba_3371b3b2967e
is: SBO:0000252
type: Species
name: CA5B
is encoded by: hsa:11238
initial concentration: NaN
is: Q9Y2D0
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false

metaR LINKDEG1ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
is described by: ECO:0000000
fast: false
name: degradation of proteoglycan linkage region, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110009#_b4032ae0_3c00_434e_9dd4_c64ee6250e9c
is encoded by: hsa:83884
name: SLC25A2
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is: Q9BXI2

metaM pyr m
name: pyruvate
is: C00022
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: http://identifiers.org/pubchem.compound/3324
initial concentration: 1.0
boundary condition: false
is: CHEBI:15361
is: HMDB00243
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaR r1607
fast: false
product: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true

metaM cyan c
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
name: hydrogen cyanide
has only substance units: false
is: CHEBI:18407
is: HMDB02084
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_52be7fb4_beed_48c9_8a4f_28c4eb21cdde
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: O00154
is: SBO:0000252
is encoded by: hsa:11332
has only substance units: false
type: Species
name: ACOT7

metaR HS2ly
name: heparan-N-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.10.1.1
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
fast: false
is: SBO:0000176
type: Reaction
reversible: false
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
modifier: MODEL1310110009#
product: MODEL1310110009#

metaM ksi deg36 l
constant: false
initial amount: NaN
is: HMDB00143
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
name: keratan sulfate I, degradation product 36
initial concentration: 1.0
boundary condition: false
is: CHEBI:12936

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaR FAOXC61m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_39ca5940_f39d_4752_98e5_c90e800814d9
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:760
is: P00918
has only substance units: false
type: Species
constant: false
initial concentration: NaN
name: CA2

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_1a004e75_88cd_4943_b162_176f0602e15c
initial concentration: NaN
is: P54819
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:204
initial amount: NaN
type: Species
name: AK2

metaR STRDNCt
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
type: Reaction
reactant: MODEL1310110009#
name: fatty acid transport via diffusion

metaR r0630
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.2
reactant: MODEL1310110009#
modifier: MODEL1310110009#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.1
kinetic law: MODEL1310110009#
fast: false
is: SBO:0000176
reversible: true
product: MODEL1310110009#

metaR r1609
is described by: ECO:0000000
product: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110009#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_d33e4010_88eb_4464_9ce0_26524c8e7807
name: ST3GAL3
is: SBO:0000252
type: Species
is encoded by: hsa:6487
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

metaM ksii core4 pre3 g
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 3
is: CHEBI:58053
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C55H89N5O38X CHARGE: -1
initial amount: NaN
type: Species
is: HMDB00175
constant: false
is: C00130

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaM pre prot r
initial concentration: 1.0
name: glycophosphatidylinositol (GPI)-anchored protein precursor
is: CHEBI:16240
initial amount: NaN
is: HMDB03125
type: Species
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: XY CHARGE: 0

metaM gdpfuc c
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:57984
is: HMDB01095
constant: false
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
name: GDP-L-fucose(2-)

metaM asp L m
is: SBO:0000247
is: HMDB00191
boundary condition: false
type: Species
constant: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
has only substance units: false
is: CHEBI:29991
initial concentration: 1.0
initial amount: NaN
name: L-aspartate(1-)

metaM CE5867 e
is: SBO:0000247
is: CHEBI:27485
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H32N5O9 CHARGE: -1 INCHI: InChI=1/C20H33N5O9/c1-11(27)22-14(10-26)18(31)24-13(9-16(28)29)17(30)23-12(5-2-3-7-21)19(32)25-8-4-6-15(25)20(33)34/h12-15,26H,2-10,21H2,1H3,(H,22,27)(H,23,30)(H,24,31)(H,28,29)(H,33,34)/p-1/t12-,13+,14-,15-/m0/s1 EHMN_ABBREVIATION: CE5867
constant: false
is: HMDB02710
type: Species
name: N-acetyl-seryl-aspartyl-lysyl-proline
boundary condition: false

metaM CE2431 m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:57795
type: Species
is: SBO:0000247
name: cis-deca-4-enoyl-CoA
initial concentration: 1.0
constant: false

metaM cmpacna n
is: SBO:0000247
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: HMDB01176
name: CMP-N-acetyl-beta-neuraminate(2-)
initial amount: NaN
is: CHEBI:57812

metaR r0650
product: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
reactant: MODEL1310110009#
reversible: true
is version of: http://identifiers.org/ec-code/4.1.1.36
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110009#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
fast: false
type: Reaction

metaR RE1836X
reactant: MODEL1310110009#
type: Reaction
fast: false
modifier: MODEL1310110009#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.176
is: SBO:0000176
name: RE1836
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
product: MODEL1310110009#

metaR HISCAT1
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_a2482bcf_7c4e_4a08_9c57_2c4b0ed6dcd2
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:AI971023
initial amount: NaN
name: _AI971023_1_c
is: SBO:0000252
boundary condition: true

metaR GLCNACT U
reversible: false
type: Reaction
product: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000176
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (uterus)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
fast: false

metaR FAOXC12C10m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_1e53a098_0290_4bc6_bf6c_e7e76b1236ef
is: O95498
is encoded by: hsa:8875
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
name: VNN2
is: SBO:0000252

metaR UDPDOLPT U
kinetic law: MODEL1310110009#
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:10359825,PMID:8280060 NOTES:NCD
reactant: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (uterus)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.117
modifier: MODEL1310110009#

metaM HC02216 c
is: SBO:0000247
constant: false
name: prostaglandin-f2beta
initial concentration: 1.0
boundary condition: false
is: CHEBI:28922
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_724521a7_cdca_4560_b1fa_144f486521b3
initial amount: NaN
initial concentration: NaN
name: IDH3G
has only substance units: false
constant: false
is: P51553
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3421

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_2cd9e17d_27cd_4777_a9fc_9c4401f564b8
is encoded by: hsa:28976
name: ACAD9
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is: Q9H845

http://identifiers.org/biomodels.db/MODEL1310110009#_fb5fac7e_2c8e_4a25_afca_bf08f3545377
type: Species
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:6185
name: RPN2
is: P04844
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_c732b77e_abf9_47a7_996c_be01b562bdab
initial concentration: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
initial amount: NaN
name: AGPAT4
is: Q9NRZ5
is: SBO:0000252
is encoded by: hsa:56895

metaR r2419
reversible: true
fast: false
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaR DNDPt32m
modifier: MODEL1310110009#
type: Reaction
fast: false
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110009#
name: dGDP transport via ATP antiport
reversible: false
kinetic law: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR DHPM2
reactant: MODEL1310110009#
product: MODEL1310110009#
reversible: false
fast: false
kinetic law: MODEL1310110009#
name: dihydropyrimidinase (dihydrothymine)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 2 AUTHORS: NOTES:Also acts on dihydrothymine and hydantoin. Found not specific evidence in PubMed, but Dihydropyrimidinase is supposed to be in cytosol and catalyze this reaction. Old information
type: Reaction
is: SBO:0000176

metaM pail45p hs c
constant: false
name: phosphatidylinositol 4,5-bisphosphate
is: CHEBI:28910
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637

http://identifiers.org/biomodels.db/MODEL1310110009#_35a57742_5199_4849_91cf_092687674f58
boundary condition: true
is: Q96KH8
is: SBO:0000252
type: Species
constant: false
name: SLC6A2
is encoded by: hsa:6530
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR r0973
fast: false
reversible: true
name: Facilitated diffusion
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
product: MODEL1310110009#
is: SBO:0000185
kinetic law: MODEL1310110009#

metaM etfrd m
notes: FORMULA: RH2 CHARGE: 0
is: HMDB01356
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
name: Electron transfer flavoprotein reduced
is: CHEBI:57312
initial concentration: 1.0
constant: false

metaR RE2626M
is version of: http://identifiers.org/ec-code/1.14.13.15
name: RE2626
fast: false
kinetic law: MODEL1310110009#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
modifier: MODEL1310110009#
reversible: true
product: MODEL1310110009#

metaR LACLt
reversible: false
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMCID: PMC1820816. NOTES:for regeneration of nad in peroxisomes, for providing nad to the beta oxidation
type: Reaction
is described by: ECO:0000134
fast: false
name: Lactate transport

metaM HC02216 e
initial concentration: 1.0
is: SBO:0000247
type: Species
name: prostaglandin-f2beta
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:28922
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_3b380566_ff34_4475_a056_c368a63148c6
boundary condition: true
is encoded by: hsa:3295
name: HSD17B4
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: E9PB82
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_3f3db2f2_73e1_4536_a1e1_6db8df2058ba
has only substance units: false
initial concentration: NaN
is encoded by: hsa:114
is: Q4F7X0
name: ADCY8
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_e790961f_f57a_442a_9339_24471881415e
is: O00483
is: SBO:0000252
name: NDUFA4
is encoded by: hsa:4697
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
type: Species

metaM 2hexdtetcoa m
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
is: HMDB02288
type: Species
name: 2,7,10,13-hexadecatetraenoylcoa

metaR DHPM1
modifier: MODEL1310110009#
reversible: false
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.2.2
is: SBO:0000176
reactant: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
kinetic law: MODEL1310110009#
name: dihydropyrimidinase (5,6-dihydrouracil)

http://identifiers.org/biomodels.db/MODEL1310110009#_e5ca828e_1ebb_4aa1_92a7_58964716d45a
initial amount: NaN
type: Species
is encoded by: hsa:3425
name: IDUA
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
is: P35475

http://identifiers.org/biomodels.db/MODEL1310110009#_8e98d108_35b8_450a_b5c7_d242eaba9069
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: F5H6D0
is encoded by: hsa:7841
type: Species
name: MOGS
constant: false

metaR CSNATr
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: true
fast: false
type: Reaction
product: MODEL1310110009#
name: carnitine O-acetyltransferase
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
is described by: ECO:0000000

metaR SCP21x
modifier: MODEL1310110009#
name: Sterol carrier protein 2
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.176
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110009#
fast: false
is: SBO:0000185

metaR FAOXC61x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)x
type: Reaction

metaM dmnoncrn c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: 4,8-dimethylnonanoyl carnitine
type: Species
is: HMDB06202
constant: false
notes: FORMULA: C18H37NO4 CHARGE: 0

metaR RETH1e
reactant: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: retinyl ester hydrolase (9-cis), extracellular
type: Reaction
reversible: false
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110009#

metaR DRBK
type: Reaction
reactant: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.15
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.15 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
is described by: ECO:0000304
fast: false
name: Deoxyribokinase
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_f53183ee_e818_440b_b726_632ab1896b8b
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:1376
is: SBO:0000252
name: CPT2
constant: false
is: P23786

metaM nad r
is: HMDB00902
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57540
name: NAD(1-)
constant: false
initial amount: NaN
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
initial concentration: 1.0
type: Species

metaM nrpphrsf e
is: HMDB02062
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
is: SBO:0000247
name: Sulfate derivative of norepinephrine
has only substance units: false
is: http://identifiers.org/pubchem.compound/123747

metaR r0377
type: Reaction
reversible: false
product: MODEL1310110009#
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176
fast: false
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:

metaR GALASE20ly
is described by: ECO:0000000
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000176
name: beta-galactosidase, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction

metaR FTHFLm
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.3
notes: GENE_ASSOCIATION: (25902.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.4.3 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
reversible: true
name: formate-tetrahydrofolate ligase, mitochondrial
product: MODEL1310110009#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#

metaR FACOAL226
kinetic law: MODEL1310110009#
name: fatty-acid--CoA ligase
product: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
modifier: MODEL1310110009#
reversible: true

metaR UDPtl
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
type: Reaction
name: udp intracellular transport
reactant: MODEL1310110009#

metaM maltpt e
is: http://identifiers.org/pubchem.compound/5141
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
type: Species
is: HMDB01296
is: SBO:0000247
has only substance units: false
name: maltopentaose
is: C02052
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false

metaR RE1531M
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
type: Reaction
is described by: ECO:0000000
name: RE1531
product: MODEL1310110009#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110009#_8a20c3a6_02c2_4da1_bdc8_40358d40078a
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5471
has only substance units: false
is: Q06203
is: SBO:0000252
name: PPAT
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_297ac9a8_bdc7_4ea3_ab11_1a8522fc0528
is encoded by: hsa:10400
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: Q9UBM1
name: PEMT
initial amount: NaN

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaR CSNATp
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.7
kinetic law: MODEL1310110009#
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
reversible: true
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
fast: false

metaR UPPN
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
is: SBO:0000176
name: b-ureidopropionase
reversible: false
fast: false
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.5.1.6
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_f0456067_0622_4b3c_b9ee_d4c0084124fd
is encoded by: hsa:H77542
name: _H77542_1_c
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_87efde7e_163d_48b8_8073_dd7796f0172e
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
name: SLC25A11
is: F5GY65
is encoded by: hsa:8402
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_2139480a_6463_416d_9672_be24f5b5ca06
name: GCK
initial amount: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:2645
is: Q53Y25
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_74b9d6a9_3fe3_4cf5_be8a_9feb403e8204
initial concentration: NaN
is: O75964
is encoded by: hsa:10632
name: ATP5L
is: SBO:0000252
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN

metaM xol7ah3 c
is: CHEBI:28540
boundary condition: false
name: 5beta-cholestane-3alpha,7alpha,26-triol
type: Species
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB12455

metaR EX c6crn
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hexanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_f4ab5387_ce9a_4e9c_8f3f_744dac7f6563
has part: P11182
initial amount: NaN
has part: P21953
is encoded by: hsa:593
has only substance units: false
is encoded by: hsa:594
constant: false
boundary condition: true
has part: B4DP47
is encoded by: hsa:1629
type: Species
initial concentration: NaN
is: SBO:0000297
name: DBT:DLD:BCKDHA:BCKDHB

http://identifiers.org/biomodels.db/MODEL1310110009#_086591f7_9c29_4ed1_891b_676c204cc59a
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
name: SGSH
is: P51688
type: Species
is encoded by: hsa:6448

http://identifiers.org/biomodels.db/MODEL1310110009#_1e573fc6_dc74_4e8f_ae9a_c8d16481a739
name: _AV713053_1_m
type: Species
has only substance units: false
is encoded by: hsa:AV713053
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR FAOXC164m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaR RE0935E
kinetic law: MODEL1310110009#
is: SBO:0000176
name: RE0935
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.17
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
modifier: MODEL1310110009#
reactant: MODEL1310110009#
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.1
product: MODEL1310110009#

metaM mma c
is: HMDB00164
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:59338
type: Species
name: methylammonium
constant: false
notes: FORMULA: C1H6N CHARGE: 1 INCHI: InChI=1S/CH5N/c1-2/h2H2,1H3/p+1 EHMN_ABBREVIATION: C00218

http://identifiers.org/biomodels.db/MODEL1310110009#_f0a08508_3178_487c_8393_df37e55633b0
initial concentration: NaN
constant: false
boundary condition: true
is: Q6FH11
type: Species
initial amount: NaN
name: HMOX1
has only substance units: false
is encoded by: hsa:3162
is: SBO:0000252

metaR FACOAL224
type: Reaction
kinetic law: MODEL1310110009#
name: fatty-acid--CoA ligase
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110009#
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: true
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_209cb215_0792_4fe5_9ac5_5bf99a6e1832
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is: Q6NZ59
is encoded by: hsa:522
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ATP5J

metaR PSFLIPm
product: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.6.3.1
name: phosphatidylserine flippase
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
reversible: false
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185

metaM ethamp c
name: ethamp[c]
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: SBO:0000247
has only substance units: false
is: HMDB00224
initial amount: NaN
is: CHEBI:58190
boundary condition: false

metaR FAOXC16BRx
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16br)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_8ec45f5b_7c72_4e0d_b5da_e06922ce19da
has only substance units: false
is encoded by: hsa:1836
constant: false
initial concentration: NaN
is: P50443
type: Species
initial amount: NaN
boundary condition: true
name: SLC26A2
is: SBO:0000252

metaR FAOXC16DCr
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

metaM 4mop e
constant: false
name: 4-methyl-2-oxopentanoate
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
initial amount: NaN
boundary condition: false
is: HMDB00695
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:17865

metaR r1899
reversible: false
kinetic law: MODEL1310110009#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110009#
product: MODEL1310110009#
name: Y+LAT2 Utilized transport
type: Reaction

metaR CSNATm
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
is described by: ECO:0000269
name: carnitine O-aceyltransferase, mitochondrial
is: SBO:0000176
reactant: MODEL1310110009#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.7
reversible: true

metaR C3STKR2r
reactant: MODEL1310110009#
fast: false
product: MODEL1310110009#
type: Reaction
is described by: ECO:0000134
name: C-3 sterol keto reductase (zymosterol)
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110009#
is: SBO:0000176

metaM ethamp r
is: HMDB00224
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: SBO:0000247
is: CHEBI:58190
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: O-phosphonatoethanaminium(1-)

http://identifiers.org/biomodels.db/MODEL1310110009#_992d35d2_0b99_4bc4_b58e_dab6bfe7197d
initial concentration: NaN
initial amount: NaN
name: NAGK
constant: false
is: SBO:0000252
is: Q9UJ70
has only substance units: false
boundary condition: true
is encoded by: hsa:55577
type: Species

metaR r1493
is: SBO:0000185
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15845416 NOTES:
type: Reaction
kinetic law: MODEL1310110009#
reversible: false
name: Utilized transport
fast: false
reactant: MODEL1310110009#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_e28ab8c5_9efd_463b_974c_e10626acedf1
name: SUCLG1
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:8802
boundary condition: true
is: P53597
type: Species
initial amount: NaN
is: SBO:0000252

metaR EX CE1943 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermidine dialdehyde exchange
type: Reaction

metaR RE1520M
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110009#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1520
is described by: ECO:0000000
product: MODEL1310110009#

metaR DGK1
reactant: MODEL1310110009#
name: deoxyguanylate kinase (dGMP:ATP)
reversible: true
kinetic law: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110009#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.8
type: Reaction
modifier: MODEL1310110009#
is described by: ECO:0000269

metaR DCSPTN1CPT1
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
reversible: false
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176

metaM fru c
is: HMDB00660
name: D-Fructose
is: C00095
is: CHEBI:15824
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_d320d667_7780_45dd_add0_3c26d6a7f135
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:6901
initial concentration: NaN
is: Q16635
constant: false
is: SBO:0000252
name: TAZ
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_5250324d_d36e_4b6c_8e83_6e83070fc86a
boundary condition: true
initial amount: NaN
name: SLC6A6
is: Q9BRI2
is encoded by: hsa:6533
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_0c0b76c2_e509_4e0a_acdc_a3ae5fd26e7d
is: SBO:0000252
has only substance units: false
constant: false
name: FUCA1
boundary condition: true
initial amount: NaN
is encoded by: hsa:2517
is: P04066
type: Species
initial concentration: NaN

metaR ASNCYSNaEx
is: SBO:0000185
modifier: MODEL1310110009#
product: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
is described by: ECO:0000269
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
fast: false
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaM r5p c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
type: Species
name: alpha-D-Ribose 5-phosphate
is: C00117
initial amount: NaN
boundary condition: false
is: CHEBI:18189
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
is: HMDB00618

http://identifiers.org/biomodels.db/MODEL1310110009#_439787c3_6faf_4620_bc3e_f3eff9694b3b
is: Q5QPH3
is encoded by: hsa:55902
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
name: ACSS2
initial concentration: NaN
has only substance units: false
type: Species

metaM mn l
constant: false
type: Species
is: HMDB06535
initial amount: NaN
boundary condition: false
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
has only substance units: false
initial concentration: 1.0
name: beta-1,4-mannose-N-acetylglucosamine
is: SBO:0000247

metaR FAOXC164x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)x
type: Reaction

metaM prostge2 c
type: Species
is: HMDB01220
initial amount: NaN
is: CHEBI:606564
name: prostaglandin E2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM cmpacna g
initial amount: NaN
is: HMDB01176
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
name: CMP-N-acetyl-beta-neuraminate(2-)
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:57812

metaM co c
is: SBO:0000247
initial concentration: 1.0
is: HMDB01361
initial amount: NaN
is: CHEBI:17245
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
name: carbon monoxide
has only substance units: false
constant: false
boundary condition: false
type: Species

metaM nrpphrsf c
name: Sulfate derivative of norepinephrine
initial concentration: 1.0
is: HMDB02062
has only substance units: false
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/123747
type: Species

metaR ALAtN1
name: Alanine transport (Na, H coupled)
product: MODEL1310110009#
is described by: ECO:0000269
type: Reaction
fast: false
modifier: MODEL1310110009#
reversible: true
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is: SBO:0000185

metaR G6PDH2rer
is: SBO:0000176
modifier: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000269
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.47
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
fast: false
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
reversible: true

metaM ksi deg17 l
constant: false
is: HMDB00143
type: Species
name: keratan sulfate I, degradation product 17
is: CHEBI:12936
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_14178af6_82d3_4e53_bca0_9eefa0508bc9
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: SLC26A11
type: Species
constant: false
is: Q86WA9
is encoded by: hsa:284129
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_85a9cdea_a5d7_4b3d_a85e_a6a2c4b8d69f
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5313
name: PKLR
initial concentration: NaN
type: Species

metaM fru e
has only substance units: false
is: SBO:0000247
is: C00095
is: CHEBI:15824
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
initial amount: NaN
initial concentration: 1.0
name: D-Fructose
constant: false
boundary condition: false
is: HMDB00660

metaR EX 3mlda LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-Methylimidazoleacetic acid exchange
type: Reaction

metaR RE0577C
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.2
reactant: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.65
name: RE0577
reversible: true
kinetic law: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
is: SBO:0000176
modifier: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_d03be2ca_3c6c_4967_873e_328bdc7fbdb3
has only substance units: false
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: _NOS2A_1_e
is encoded by: hsa:NOS2A

metaM Ser Gly Ala X Gly l
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:36005
is: HMDB02183
notes: FORMULA: XH CHARGE: 0
initial amount: NaN
name: protein-linked serine residue (glycosaminoglycan attachment site)

metaM cs a deg4 l
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
is: SBO:0000247
is: CHEBI:57455
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: HMDB01354
has only substance units: false
notes: FORMULA: C31H49NO29S CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110009#_f239ca90_c222_4b75_928f_a05e32264521
boundary condition: true
type: Species
name: GCAT
initial concentration: NaN
constant: false
is encoded by: hsa:23464
has only substance units: false
initial amount: NaN
is: E2QC23
is: SBO:0000252

metaR DCSPTN1CPT2
modifier: MODEL1310110009#
is: SBO:0000176
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110009#
reversible: false
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false

metaR FADDPle
modifier: MODEL1310110009#
fast: false
is described by: ECO:0000134
name: FAD diphosphatase
reversible: false
product: MODEL1310110009#
is: SBO:0000176
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (5167.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/3.1.4.1
reactant: MODEL1310110009#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_b0c27fc5_f3da_453d_a15a_bd7c15c0276b
is: SBO:0000252
is encoded by: hsa:AU149534
has only substance units: false
constant: false
initial concentration: NaN
type: Species
name: _AU149534_1_m
initial amount: NaN
boundary condition: true

metaR PI345P5P
fast: false
reversible: false
product: MODEL1310110009#
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.56
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.1.3.36
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.86

metaR TYRCBOX
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/4.1.1.28
is: SBO:0000176
reactant: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
name: L-Tyrosine carboxy-lyase
reversible: false
modifier: MODEL1310110009#
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110009#

metaM co e
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB01361
is: CHEBI:17245
initial concentration: 1.0
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
name: carbon monoxide
has only substance units: false
constant: false
type: Species

metaR RE2626C
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
product: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
reversible: true
kinetic law: MODEL1310110009#
fast: false
name: RE2626
is: SBO:0000176

metaM tetdecdicoa m
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
constant: false
name: 5,8-tetradecadienoylcoa
is: HMDB02288

metaR ALDD2y
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
product: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.36
type: Reaction
name: aldehyde dehydrogenase (acetaldehyde, NADP)
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
reversible: false
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_042c28a3_a785_425a_913d_a66dec4ae476
has only substance units: false
initial concentration: NaN
is encoded by: hsa:51102
constant: false
boundary condition: true
is: Q9BV79
name: MECR
initial amount: NaN
is: SBO:0000252
type: Species

metaR ARACHCPT1
modifier: MODEL1310110009#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110009#
kinetic law: MODEL1310110009#
name: carnitine transferase
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
fast: false

metaR G14T13g
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
reactant: MODEL1310110009#
product: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110009#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000

metaM HC01115 c
name: NeuNGc
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
constant: false
is: CHEBI:29025

metaR NODe
is described by: ECO:0000134
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: NODe
fast: false

metaR NDP10ex
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
is described by: ECO:0000269
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.6.1.6
reactant: MODEL1310110009#
name: nucleoside-diphosphatase (IDP), extracellular

http://identifiers.org/biomodels.db/MODEL1310110009#_326f7adb_249b_48f5_bab3_10bddcfb25c2
is: Q16836
has only substance units: false
is encoded by: hsa:3033
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
name: HADH

metaM gdpfuc g
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: GDP-L-fucose(2-)
boundary condition: false
is: HMDB01095
type: Species
is: CHEBI:57984
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325

metaR r0541
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
type: Reaction
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
product: MODEL1310110009#
reactant: MODEL1310110009#
reversible: true
fast: false
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000000

metaM frdp x
is: CHEBI:175763
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00961
is: SBO:0000247
name: farnesyl pyrophosphate(3-)
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_cd9d3909_2459_4ba8_88ea_92619341478f
name: MTHFD1
constant: false
initial concentration: NaN
is encoded by: hsa:4522
boundary condition: true
is: P11586
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252

metaM 9 cis retfa e
has only substance units: false
constant: false
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
initial amount: NaN
is: SBO:0000247
type: Species
name: fatty acid 9-cis-retinol
initial concentration: 1.0
boundary condition: false
is: HMDB06559

metaM hyptaur c
constant: false
is: HMDB00965
type: Species
name: Hypotaurine
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:16668
initial amount: NaN
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_7663c735_7fd3_4f25_9be3_eaa25216e1b3
name: ACOX2
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:8309
constant: false
is: Q99424
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_216a0852_e7b9_465c_9889_115301022b44
has only substance units: false
is: SBO:0000252
type: Species
name: AK2
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:204
initial concentration: NaN

metaM cbasp e
notes: FORMULA: C5H6N2O5 CHARGE: -2
is: HMDB00828
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:32814
name: N-Carbamoyl-L-aspartate
constant: false
initial amount: NaN
is: C00438

metaR UMPK5n
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (dATP),nuclear
reversible: true
product: MODEL1310110009#
is described by: ECO:0000269
reactant: MODEL1310110009#
is: SBO:0000176
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
fast: false

metaR PI45P5Pn
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase, nuclear
type: Reaction
reversible: false
fast: false
product: MODEL1310110009#
kinetic law: MODEL1310110009#

metaM dmnoncrn m
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB06202
name: 4,8 dimethylnonanoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110009#_785795bd_fffd_45c1_932e_4ba16a51fde7
is: SBO:0000252
constant: false
is encoded by: hsa:2222
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
name: FDFT1
is: P37268
boundary condition: true

metaR PSt3
reversible: true
product: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
fast: false
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
name: phosphatidylserine transport

metaR r0974
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
reactant: MODEL1310110009#
reversible: true
name: Active transport
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_fc8daefc_32fb_4292_b3e2_0b7809b64a66
type: Species
name: ALDH1B1
is: P30837
boundary condition: true
is: SBO:0000252
is encoded by: hsa:219
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false

metaR AKGDm
is: SBO:0000176
reactant: MODEL1310110009#
is described by: ECO:0000134
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.8.1.4
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.2.4.2
is version of: http://identifiers.org/ec-code/2.3.1.61
type: Reaction
name: 2-oxoglutarate dehydrogenase
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (4967.2) and (1738.1 and 8050.1) and (1743.1) or (4967.1) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Citric acid cycle EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:1542694 NOTES:EC taken from Ligand TV. Genetic
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110009#_c17a08ff_4581_4762_b71f_ffcd61cb3994
constant: false
is encoded by: hsa:5333
is: P51178
type: Species
boundary condition: true
initial amount: NaN
name: PLCD1
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR CITRtm
reactant: MODEL1310110009#
is: SBO:0000185
name: citrulline mitochondrial transport via proton antiport
type: Reaction
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110009#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110009#
reversible: true
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_b69e2319_7702_41d5_b3fc_78b3b2e060b4
type: Species
is encoded by: hsa:AI091231
constant: false
name: _AI091231_1_c
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR RE0958E
name: RE0958
type: Reaction
kinetic law: MODEL1310110009#
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.17
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110009#
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
reactant: MODEL1310110009#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.1

metaM xoltetrol c
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
is: CHEBI:17278
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB01231

metaM 2hexdtetcoa x
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB02288
name: 2,7,10,13-hexadecatetraenoylcoa
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaM so3 m
initial amount: NaN
name: hydrogensulfite
is: SBO:0000247
is: HMDB00240
is: CHEBI:17137
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false

metaM 4mop c
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
name: 4-methyl-2-oxopentanoate
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
initial amount: NaN
type: Species
is: HMDB00695
initial concentration: 1.0
is: CHEBI:17865

http://identifiers.org/biomodels.db/MODEL1310110009#_9dd28b5d_31b7_43a8_80b5_8b6e1dd36ae2
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:9551
name: ATP5J2
type: Species
is: Q6IBB3

http://identifiers.org/biomodels.db/MODEL1310110009#_bad5425f_7894_4511_bebe_0b179ed98827
initial concentration: NaN
has part: Q92569
has only substance units: false
is encoded by: hsa:5293
type: Species
is: SBO:0000297
has part: A7E2E0
is encoded by: hsa:8503
initial amount: NaN
constant: false
boundary condition: true
name: PIK3CD:PIK3R3

http://identifiers.org/biomodels.db/MODEL1310110009#_7941f3e8_61b6_4331_9469_240be58d2fcf
constant: false
initial amount: NaN
type: Species
is: O43426
is: SBO:0000252
is encoded by: hsa:8867
has only substance units: false
name: SYNJ1
boundary condition: true
initial concentration: NaN

metaM 5pmev c
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1
is: SBO:0000247
name: (R)-5-phosphonatomevalonate(3-)
initial amount: NaN
type: Species
is: HMDB01343

http://identifiers.org/biomodels.db/MODEL1310110009#_c079b86f_b498_4eed_bc85_c449abd58fd3
has only substance units: false
name: HSD3B1
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3283
boundary condition: true
is: P14060
constant: false

metaR 34DHOXPEGt
reactant: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:7473774 NOTES:SAB
reversible: true
name: 3,4-Dihydroxyphenylethyleneglycol transport (diffusion)
is: SBO:0000185
product: MODEL1310110009#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_6c65ce8e_6b39_42fc_b86f_f295bb3a63a1
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51022
initial concentration: NaN
constant: false
initial amount: NaN
name: GLRX2

metaM nad m
is: http://identifiers.org/pubchem.compound/3305
is: HMDB00902
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide
is: CHEBI:57540
is: C00003

metaM cholcoar r
type: Species
is: HMDB02178
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:58677
has only substance units: false
is: SBO:0000247
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
initial concentration: 1.0

metaM ksii core2 pre1 g
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:28067
is: SBO:0000247
notes: FORMULA: C33H53N3O23X CHARGE: -1
name: keratan sulfate II biosynthesis, precursor 1
type: Species

metaM fn2m2masn g
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
is: CHEBI:32984
constant: false
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_8b1fd3d5_a709_4db9_bcc6_4778d1dc8040
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: GGT1
is: SBO:0000252
is encoded by: hsa:2678
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_27e518cb_366d_4aa3_b3d4_dd8a539b5e4e
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
is: Q8NFM4
is encoded by: hsa:196883
name: ADCY4
is: SBO:0000252

metaR FACOAL191
fast: false
name: fatty-acid--CoA ligase
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
reversible: false
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:11591435 NOTES:current models suggest COAL activity occurs on outer peroxisomal membrane NJ
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#

metaR GLCAASE7ly
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
product: MODEL1310110009#
name: beta-glucuronidase, lysosomal
modifier: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.31
fast: false
is: SBO:0000176
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_29bf0d4a_3a8d_4e5a_987f_a48e79dcabd6
has only substance units: false
constant: false
is: O43674
is: SBO:0000252
type: Species
name: NDUFB5
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4711

http://identifiers.org/biomodels.db/MODEL1310110009#_d79f2858_24b9_40d4_bb2a_db268a387692
constant: false
type: Species
has only substance units: false
name: AQP8
is: O94778
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:343
initial amount: NaN
boundary condition: true

metaR LINKDEG2ly
is described by: ECO:0000000
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
is: SBO:0000176
fast: false
reactant: MODEL1310110009#
name: degradation of proteoglycan linkage region, lysosomal
reversible: false
type: Reaction
product: MODEL1310110009#

metaM xol7ah3 m
name: 5beta-cholestane-3alpha,7alpha,26-triol
constant: false
initial concentration: 1.0
is: HMDB12455
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
is: SBO:0000247
is: CHEBI:28540
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false

metaM s2l2n2m2masn l
constant: false
is: CHEBI:18287
is: HMDB00174
has only substance units: false
type: Species
notes: FORMULA: C84H135N6O61X CHARGE: -2
initial concentration: 1.0
initial amount: NaN
name: de-Fuc form of PA6
is: SBO:0000247
boundary condition: false

metaR S6T15g
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.8.2.17
is: SBO:0000176
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.21
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000

metaR EX tdcrn
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for myristoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_afba3fd1_380b_4ad0_9a4c_9029a451f69b
boundary condition: true
is: B3KXN9
constant: false
name: ADO
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:84890
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_a25f655d_965e_4478_9643_a1d397860360
constant: false
name: ALDH1A2
is: B4DZR2
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8854
type: Species

metaR MTHFD
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
is described by: ECO:0000134
reactant: MODEL1310110009#
reversible: true
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.5
name: methylenetetrahydrofolate dehydrogenase (NADP)
is: SBO:0000176
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#

metaM 3docopencoa m
is: SBO:0000247
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
initial amount: NaN
name: 3,7,10,13,16-docosapentenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110009#_3e418047_b23c_44b8_b8dd_c4370c277faa
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5152
initial concentration: NaN
constant: false
has only substance units: false
name: PDE9A
boundary condition: true
type: Species

metaM L2aadp6sa c
is: CHEBI:17917
boundary condition: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
initial concentration: 1.0
initial amount: NaN
name: L-allysine
constant: false
type: Species
is: HMDB01263
is: SBO:0000247
has only substance units: false

metaM sbt D e
name: D-glucitol
has only substance units: false
boundary condition: false
is: HMDB00247
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_1dd1d073_3b8b_4a43_aade_95f3d4c25998
constant: false
is: SBO:0000252
name: SLC26A1
has only substance units: false
boundary condition: true
is encoded by: hsa:10861
initial concentration: NaN
initial amount: NaN
type: Species

metaR FAOXC163GC142m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaM pheacgln e
is: CHEBI:58310
is: HMDB06344
has only substance units: false
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false

metaM hdcea e
type: Species
name: Hexadecenoate (n-C16:1)
boundary condition: false
is: HMDB03229
initial concentration: 1.0
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
constant: false
is: CHEBI:32372
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_0ff924f9_9250_4948_9138_fb7e664e1815
initial amount: NaN
is: P15328
constant: false
has only substance units: false
is encoded by: hsa:2348
type: Species
name: FOLR1
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR RE1709C
product: MODEL1310110009#
is: SBO:0000176
type: Reaction
name: RE1709
reversible: true
kinetic law: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:

metaR O2t
fast: false
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
type: Reaction
name: o2 transport (diffusion)
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
reversible: true

metaR CSBPASEly
is described by: ECO:0000000
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reversible: false
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_f4a74b5a_f255_4921_9788_c392baa38e8d
is: Q8N3E9
name: PLCD3
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:113026
boundary condition: true
constant: false
initial concentration: NaN
type: Species

metaM ksi deg39 l
initial concentration: 1.0
type: Species
is: HMDB00143
notes: FORMULA: C48H81N3O36 CHARGE: 0
has only substance units: false
initial amount: NaN
name: keratan sulfate I, degradation product 39
constant: false
is: CHEBI:12936
is: SBO:0000247
boundary condition: false

metaM ksi pre22 g
is: HMDB00175
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:58053
is: C00130
name: keratan sulfate I biosynthesis, precursor 22
notes: FORMULA: C185H297N13O150S6X CHARGE: -7

http://identifiers.org/biomodels.db/MODEL1310110009#_b9f47f36_5994_4a6e_99c4_7ec1b2431e93
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR MEVK1c
modifier: MODEL1310110009#
product: MODEL1310110009#
name: mevalonate kinase (atp) cytosol
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110009#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.36
reversible: false
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.

http://identifiers.org/biomodels.db/MODEL1310110009#_2a53ddf6_51f3_4312_959a_e3f5f63b459e
initial amount: NaN
boundary condition: true
name: NSF
constant: false
type: Species
is encoded by: hsa:4905
is: P46459
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaM 3ddcrn e
is: SBO:0000247
is: C02838
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C19H37NO5 CHARGE: 0
is: HMDB00791
name: 3-hydroxydodecanoylcarnitine
constant: false
initial amount: NaN
has only substance units: false

metaR PYDAMK
is: SBO:0000176
modifier: MODEL1310110009#
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.1.35
product: MODEL1310110009#
is described by: ECO:0000269
name: pyridoxamine kinase
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM HC00695 m
type: Species
is: CHEBI:17432
name: S-Succinyldihydrolipoamide
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
is: SBO:0000247
constant: false

metaR NADPHtru
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
name: NADPH transporter, endoplasmic reticulum
product: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185
reversible: false
type: Reaction

metaR P4508B11r
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.14.13.95
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
name: sterol 12-alpha-hydroxylase
is: SBO:0000176
fast: false
reversible: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110009#
modifier: MODEL1310110009#
product: MODEL1310110009#

metaR NDPK2m
type: Reaction
modifier: MODEL1310110009#
is described by: ECO:0000254
reactant: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:UDP), mitochondrial
reversible: true
kinetic law: MODEL1310110009#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false

metaR S6TASE17ly
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110009#
product: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction

metaM malthx e
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
boundary condition: false
type: Species
is: C01936
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
name: Maltohexaose

metaM acgpail hs c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
has only substance units: false
boundary condition: false
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
constant: false
is: CHEBI:57265
type: Species
initial amount: NaN

metaM ksii core2 deg7 l
constant: false
initial amount: NaN
type: Species
name: keratan sulfate II (core 2-linked), degradation product 7
is: HMDB01354
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57455
notes: FORMULA: C44H73N4O30X CHARGE: 0

metaM sbt D c
type: Species
constant: false
name: D-glucitol
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
is: CHEBI:17924
is: HMDB00247

http://identifiers.org/biomodels.db/MODEL1310110009#_71e79611_d758_47f0_bc25_ee0937cb8424
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
name: _LOC374569_1_e
is: SBO:0000252
is encoded by: hsa:LOC374569
constant: false

metaR ALDD2x
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
name: aldehyde dehydrogenase (acetaldehyde, NAD)
is version of: http://identifiers.org/ec-code/1.2.1.36
kinetic law: MODEL1310110009#
reversible: false
product: MODEL1310110009#
modifier: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_c65a1710_4b47_4e32_913b_3eeb84c5d09a
has only substance units: false
initial concentration: NaN
type: Species
name: PPCS
is: SBO:0000252
is: Q9HAB8
initial amount: NaN
is encoded by: hsa:79717
constant: false
boundary condition: true

metaM cbasp c
has only substance units: false
type: Species
initial concentration: 1.0
name: N-Carbamoyl-L-aspartate
is: C00438
constant: false
initial amount: NaN
is: HMDB00828
boundary condition: false
is: CHEBI:32814
is: SBO:0000247
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438

metaR ARACHCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
name: carnitine transferase
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110009#

metaR HDCACBP
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydecanoyl-CoA from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_6da141b8_682a_4ab7_856f_048152cb7a55
is: O60488
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2182
type: Species
constant: false
name: ACSL4
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_8d92addb_38cb_4f0d_b8ad_c15d27c889f1
is: P13995
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:10797
type: Species
is: SBO:0000252
name: MTHFD2
initial concentration: NaN

metaR HYXNt
kinetic law: MODEL1310110009#
fast: false
is: SBO:0000185
reactant: MODEL1310110009#
type: Reaction
modifier: MODEL1310110009#
product: MODEL1310110009#
name: Hypoxanthine transport
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv

metaM ksi pre24 g
constant: false
name: keratan sulfate I biosynthesis, precursor 24
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00175
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
is: C00130
is: CHEBI:58053
is: SBO:0000247

metaR NDPK2n
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
fast: false
modifier: MODEL1310110009#
reversible: true
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is: SBO:0000176
type: Reaction
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
reactant: MODEL1310110009#

metaR r0531
reversible: true
type: Reaction
modifier: MODEL1310110009#
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.34
product: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#

metaR DCYTDn
type: Reaction
reactant: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000176
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.5.4.5
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
name: deoxycytidine deaminase, nuclear
reversible: false
fast: false
modifier: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_394e0b56_133b_4356_9e0f_e6b9f1774357
boundary condition: true
is encoded by: hsa:4668
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P17050
constant: false
type: Species
is: SBO:0000252
name: NAGA

http://identifiers.org/biomodels.db/MODEL1310110009#_fc9cfd10_779c_4c23_b8f4_95e3fbba5f65
name: DCTD
is encoded by: hsa:1635
constant: false
has only substance units: false
is: P32321
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR FACOAL184
type: Reaction
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: true
is described by: ECO:0000000
fast: false
name: fatty-acid--CoA ligase
modifier: MODEL1310110009#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110009#_baa77165_8c04_4807_8e80_5434a4c1547e
initial amount: NaN
is encoded by: hsa:6524
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is: P31639
constant: false
has only substance units: false
name: SLC5A2

metaM ksi pre9 g
is: CHEBI:58053
is: HMDB00175
is: C00130
has only substance units: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 9
boundary condition: false
initial amount: NaN
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
type: Species
constant: false
initial concentration: 1.0

metaR NAtx
name: sodium transport via diffusion (perioxisome)
fast: false
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110009#_ee6a17f7_3ffd_4887_a83e_35ee1b1da800
is: P23378
initial amount: NaN
name: GLDC
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:2731
constant: false

metaR ADAe
fast: false
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.5.4.4
name: Adenosine deaminase, extracellular
type: Reaction
reversible: false
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110009#
kinetic law: MODEL1310110009#

metaR SMPD3g
product: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
reactant: MODEL1310110009#
is described by: ECO:0000304
kinetic law: MODEL1310110009#
type: Reaction
modifier: MODEL1310110009#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.12
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)

metaM cmpacna c
initial concentration: 1.0
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: CHEBI:57812
is: HMDB01176
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
name: CMP-N-acetyl-beta-neuraminate(2-)
type: Species

metaM nad c
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3305
constant: false
has only substance units: false
is: C00003
is: CHEBI:57540
boundary condition: false
type: Species
name: Nicotinamide adenine dinucleotide
is: HMDB00902
initial amount: NaN

metaM hpdcacoa c
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
name: heptadecanoyl coa
initial amount: NaN
is: HMDB06497
constant: false
type: Species
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1

metaR LPS
name: lipase
is described by: ECO:0000000
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.1.1.34
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:carbonyl and extra H accounted for in R group NJ
reversible: false
type: Reaction
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_a93fefd5_36c5_491f_bde9_8df84490f9ae
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: O15357
is encoded by: hsa:3636
type: Species
is: SBO:0000252
name: INPPL1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_14644e03_9800_4fdd_8112_789fbae8e66a
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q92536
is encoded by: hsa:9057
name: SLC7A6
constant: false
initial amount: NaN
is: SBO:0000252
type: Species

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_31aef840_4618_4dc7_82a5_16c68f842b33
name: DEGS1
initial amount: NaN
is encoded by: hsa:8560
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: O15121
constant: false

metaR ACACT1x
product: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
is described by: ECO:0000134
modifier: MODEL1310110009#
is: SBO:0000176
name: acetyl-CoA C-acetyltransferase, mitochondrial
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.9
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_c126ad56_8d0f_4d5c_ba63_31d8124e1d93
has only substance units: false
type: Species
is encoded by: hsa:5168
constant: false
is: SBO:0000252
name: ENPP2
initial amount: NaN
boundary condition: true
is: Q13822
initial concentration: NaN

metaM dhcrm hs c
initial amount: NaN
is: CHEBI:31488
type: Species
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
name: dihydroceramide
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR r2420
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110009#
product: MODEL1310110009#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_c7e9a449_85a4_44cd_a253_71851c6fc3a8
is: B2RB47
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:271
type: Species
name: AMPD2
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true

metaR S4TASE2ly
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.12
modifier: MODEL1310110009#
reactant: MODEL1310110009#
reversible: true
is described by: ECO:0000000
name: N-acetylgalactosamine-4-sulfatase, lysosomal
kinetic law: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD

metaM core2 g
is: CHEBI:15876
type: Species
boundary condition: false
initial amount: NaN
name: Core 2
initial concentration: 1.0
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: SBO:0000247
has only substance units: false
constant: false

metaR GLAl
fast: false
notes: GENE_ASSOCIATION: (2717.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.22 Confidence Level: 4 AUTHORS: PMID:11775551,PMID:11828341,PMID:15003450,PMID:2836863 NOTES:NJ
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.22
is: SBO:0000176
name: galactosidase, alpha
reversible: false
reactant: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_b2a2be62_bd44_4097_a219_26a1b6b87884
constant: false
is: P54802
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:4669
initial amount: NaN
initial concentration: NaN
name: NAGLU
has only substance units: false

metaM hs deg22 l
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
has only substance units: false
is: HMDB02704
notes: FORMULA: C37H56NO35S CHARGE: -3
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:21338
type: Species
initial amount: NaN
initial concentration: 1.0

metaM n2m2nm l
type: Species
is: CHEBI:57312
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C58H97N5O41 CHARGE: 0
initial amount: NaN
has only substance units: false
is: HMDB01356
name: n2m2nmasn (w/o peptide linkage)
is: SBO:0000247

metaM dmnoncrn x
name: 4,8-dimethylnonanoyl carnitine
has only substance units: false
is: HMDB06202
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C18H37NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110009#_1e1746b4_6dfb_4d74_aa28_febe7bc571eb
is: O76082
is encoded by: hsa:6584
name: SLC22A5
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaM crtsl r
is: SBO:0000247
has only substance units: false
notes: FORMULA: C21H30O5 CHARGE: 0 INCHI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00735
boundary condition: false
name: cortisol
is: CHEBI:17650
constant: false
is: HMDB00063
initial amount: NaN
type: Species
initial concentration: 1.0

metaR ARACHt
fast: false
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110009#
is: SBO:0000185
reactant: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
reversible: true
name: fatty acid transport via diffusion

metaR r0647
fast: false
name: Spontaneous reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
is: SBO:0000176
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#

metaM pheacgln c
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:58310
constant: false
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
has only substance units: false
initial amount: NaN
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
boundary condition: false
is: HMDB06344

http://identifiers.org/biomodels.db/MODEL1310110009#_195b7c18_23bc_4885_a8dc_1294ce11cd21
initial concentration: NaN
is encoded by: hsa:AL048840
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: _AL048840_1_c

http://identifiers.org/biomodels.db/MODEL1310110009#_46332d42_ba2b_4f72_8aab_08c05e8dde4f
is encoded by: hsa:51102
has only substance units: false
is: SBO:0000252
constant: false
is: Q9BV79
name: MECR
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_986ff982_50b6_4aab_a828_3a6cba51a7f5
type: Species
is encoded by: hsa:5238
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: PGM3
is: B4DX94

metaR 5MTHFt2le
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110009#
name: 5-methyltetrahydrofolate transport via anion exchange
is described by: ECO:0000134
type: Reaction
reversible: true
fast: false
product: MODEL1310110009#
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_24ba117e_de76_4d18_ba30_ce50f8f6c5ea
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:H77542
name: _H77542_1_r
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM s2l2n2m2masn e
type: Species
is: C00255
is: HMDB00244
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:3554
constant: false
initial amount: NaN
name: de-Fuc form of PA6
notes: FORMULA: C84H135N6O61X CHARGE: -2
boundary condition: false

metaM hdcea c
initial concentration: 1.0
name: Hexadecenoate (n-C16:1)
type: Species
is: HMDB03229
has only substance units: false
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:32372

metaR S23T4g
is: SBO:0000176
fast: false
modifier: MODEL1310110009#
reversible: false
is described by: ECO:0000000
type: Reaction
name: beta-galactoside alpha-2,3-sialyltransferase
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.99.4
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
product: MODEL1310110009#

metaR PROSTGI2t
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
reversible: true
name: Prostaglandin I2 transport
is described by: ECO:0000269
product: MODEL1310110009#
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110009#

metaR GHMT2r
reversible: true
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
kinetic law: MODEL1310110009#
name: glycine hydroxymethyltransferase, reversible
is version of: http://identifiers.org/ec-code/2.1.2.1
product: MODEL1310110009#

metaR FAOXC11
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211 1 round of beta ox of branched chain FA from peroxisome NJ
reactant: MODEL1310110009#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110009#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110009#
name: Beta oxidation of long chain fatty acid
product: MODEL1310110009#
type: Reaction

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaM CE2424 m
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
has only substance units: false
initial amount: NaN
is: CHEBI:28387
is: HMDB11123
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM c6dc x
is: SBO:0000247
is: HMDB04047
is: C14143
type: Species
initial amount: NaN
name: adipoyl carnitine
constant: false
notes: FORMULA: C13H22NO6 CHARGE: -1
boundary condition: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_742a01bd_af2c_4c7f_85aa_7dbc088f0da1
initial concentration: NaN
boundary condition: true
type: Species
is: O00476
is encoded by: hsa:10786
constant: false
has only substance units: false
name: SLC17A3
initial amount: NaN
is: SBO:0000252

metaR r0226
reactant: MODEL1310110009#
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
product: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_5284807e_2ec0_429d_bd24_47447635d795
constant: false
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:3032
has only substance units: false
type: Species
is encoded by: hsa:3030
name: HADHA:HADHB
has part: P55084
initial concentration: NaN
boundary condition: true
has part: E9KL44

http://identifiers.org/biomodels.db/MODEL1310110009#_f241b97c_741f_4bf3_9162_f01ee53e7d72
initial amount: NaN
is: P51570
boundary condition: true
constant: false
name: GALK1
is: SBO:0000252
is encoded by: hsa:2584
initial concentration: NaN
has only substance units: false
type: Species

metaM udpgal c
initial concentration: 1.0
name: UDP-D-galactose(2-)
is: HMDB00302
is: CHEBI:58439
is: SBO:0000247
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species

metaM asp L c
boundary condition: false
initial amount: NaN
name: L-aspartate(1-)
initial concentration: 1.0
type: Species
is: CHEBI:29991
is: HMDB00191
has only substance units: false
is: SBO:0000247
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
constant: false

metaR r1909
modifier: MODEL1310110009#
name: Y+LAT2 Utilized transport
is: SBO:0000185
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110009#

metaM HC02214 c
type: Species
initial amount: NaN
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: CHEBI:28852
initial concentration: 1.0
name: prostaglandin-f1alpha
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_b6a0d164_b9a2_48fe_9874_d33b331741ec
name: GAL3ST1
is encoded by: hsa:9514
constant: false
type: Species
boundary condition: true
is: Q99999
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_0d015cfe_f6b4_4001_bdb9_ade60e15d3db
is: SBO:0000252
initial concentration: NaN
name: PIGC
constant: false
initial amount: NaN
is: Q92535
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:5279

metaM ura c
is: CHEBI:17568
initial concentration: 1.0
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
initial amount: NaN
name: Uracil
is: SBO:0000247
type: Species
constant: false
is: C00106
is: HMDB00300
has only substance units: false
boundary condition: false

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR O2ter
fast: false
reversible: true
reactant: MODEL1310110009#
is described by: ECO:0000000
name: O2 transport, endoplasmic reticulum
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction

metaM pail45p hs n
name: phosphatidylinositol 4,5-bisphosphate
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:28910
initial amount: NaN
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637

metaM 5aop m
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:17549
has only substance units: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: HMDB01149
name: 5-Amino-4-oxopentanoate
type: Species
is: C00430
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_d22611f0_a110_44cd_8661_dcee7b837a24
is: SBO:0000252
name: SLC2A6
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: Q9UGQ3
is encoded by: hsa:11182

http://identifiers.org/biomodels.db/MODEL1310110009#_9294de6b_f28e_492f_869f_8d0291977cd7
is: SBO:0000252
is encoded by: hsa:23530
has only substance units: false
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
name: NNT

http://identifiers.org/biomodels.db/MODEL1310110009#_bba94c27_8940_4de7_a189_453012c05493
is: P09669
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1345
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false
name: COX6C

http://identifiers.org/biomodels.db/MODEL1310110009#_cdeee37f_9584_4702_9a04_fbe21d574163
has only substance units: false
initial amount: NaN
is encoded by: hsa:957
is: O75356
name: ENTPD5
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial concentration: NaN

metaM pail45p hs m
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:28910
has only substance units: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: SBO:0000247
constant: false
name: phosphatidylinositol 4,5-bisphosphate
boundary condition: false

metaR RTOTAL3t
kinetic law: MODEL1310110009#
is: SBO:0000185
product: MODEL1310110009#
type: Reaction
fast: false
name: RTOTAL3 transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110009#
reversible: true

metaM biocyt m
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
name: Biocytin
constant: false
is: HMDB03134
has only substance units: false
is: C05552
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7886

metaR r1907
type: Reaction
modifier: MODEL1310110009#
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reversible: false
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110009#

metaM pa hs c
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
constant: false
is: CHEBI:57739
name: phosphatidate(2-)
initial concentration: 1.0
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_8ea4a803_edb5_43e8_ada3_407badb96cac
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:9245
is: SBO:0000252
name: GCNT3
boundary condition: true
is: O95395
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_f2079bce_6023_4935_a259_69c54a3c5866
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5106
name: PCK2
initial concentration: NaN
is: Q16822
initial amount: NaN
boundary condition: true
type: Species
constant: false

metaM ura e
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
is: HMDB00300
name: uracil
has only substance units: false
boundary condition: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: CHEBI:17568

metaM tetdecdicoa x
type: Species
is: HMDB02288
constant: false
boundary condition: false
name: 5,8-tetradecadienoylcoa
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR TYRt
is: SBO:0000185
modifier: MODEL1310110009#
type: Reaction
name: L-tyrosine transport
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_f056f3f2_b74a_485d_8de8_fc08846d2077
is: SBO:0000252
name: LHPP
type: Species
constant: false
initial concentration: NaN
is: Q9H008
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:64077

metaM 3decdicoa x
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species
name: 3,7-decadienoylcoa
has only substance units: false

metaR C226CPT2
reversible: false
is: SBO:0000176
name: C226 transport into the mitochondria
modifier: MODEL1310110009#
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
fast: false

metaM ksi deg7 l
notes: FORMULA: C210H337N15O181S10 CHARGE: -10
type: Species
initial amount: NaN
constant: false
name: keratan sulfate I, degradation product 7
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB01354
is: CHEBI:57455

metaR SADT
modifier: MODEL1310110009#
name: sulfate adenylyltransferase
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.25
reversible: false
reactant: MODEL1310110009#
is described by: ECO:0000269
fast: false
product: MODEL1310110009#
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_84762802_eba6_45bf_90b8_adebc04c3bfc
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q8WUX1
name: SLC38A5
is encoded by: hsa:92745
has only substance units: false
initial amount: NaN

metaR EX 11 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 11-cis-retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_fd203d19_79ad_4b92_ab64_60b3aa65836f
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
name: SLC25A26
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:115286

metaR KYNAKGAT
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.7
modifier: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
reactant: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.64
kinetic law: MODEL1310110009#
reversible: false
name: L-Kynurenine:2-oxoglutarate aminotransferase

metaR GALASE1ly
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
fast: false
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
type: Reaction
product: MODEL1310110009#

metaR r0644
reversible: true
kinetic law: MODEL1310110009#
product: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110009#
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_5df8021f_dd93_412c_9671_c681df362982
is: SBO:0000252
initial amount: NaN
is: D3DX95
name: CHAT
type: Species
is encoded by: hsa:1103
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false

metaR FAOXC12C10x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)x
type: Reaction

metaM acgam1p c
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
name: N-Acetyl-D-glucosamine 1-phosphate
initial amount: NaN
constant: false
is: HMDB01367
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:7125

metaM CE1936 e
name: spermine dialdehyde
notes: FORMULA: C10H22N2O2 CHARGE: 2 INCHI: InChI=1/C10H20N2O2/c13-9-3-7-11-5-1-2-6-12-8-4-10-14/h9-12H,1-8H2/p+2 EHMN_ABBREVIATION: CE1936
boundary condition: false
type: Species
constant: false
is: CHEBI:36781
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR r0539
is version of: http://identifiers.org/ec-code/1.1.1.34
fast: false
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000176
reversible: true
modifier: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110009#_9a5fca14_d571_4a6c_9015_cec97d595516
boundary condition: true
name: ATG9B
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:285973
initial concentration: NaN
type: Species
initial amount: NaN
is: Q674R7

metaM udpgal g
type: Species
is: HMDB00302
is: CHEBI:58439
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
boundary condition: false
name: UDP-D-galactose(2-)
is: SBO:0000247
constant: false

metaR r0641
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
reversible: true
product: MODEL1310110009#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.4
is described by: ECO:0000000
reactant: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#

metaM decdicrn c
initial concentration: 1.0
type: Species
is: HMDB13325
notes: FORMULA: C17H29NO4 CHARGE: 0
has only substance units: false
initial amount: NaN
constant: false
name: decadienoyl carnitine
is: SBO:0000247
boundary condition: false

metaM mag hs e
initial amount: NaN
constant: false
is: CHEBI:32391
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
boundary condition: false
is: SBO:0000247
name: monoacylglycerol 2
is: HMDB03073
type: Species
initial concentration: 1.0
has only substance units: false

metaM caro c
constant: false
is: CHEBI:17579
type: Species
name: beta-carotene
is: SBO:0000247
is: HMDB00561
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN

metaR FAOXC221C201x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

metaM 3ddcrn c
initial concentration: 1.0
is: HMDB00623
type: Species
constant: false
notes: FORMULA: C19H37NO5 CHARGE: 0
name: 3-hydroxydodecanoylcarnitine
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false

metaR EX ddecrn
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lauroyl carnitine
type: Reaction

metaM abt e
is: SBO:0000247
is: HMDB01851
is: CHEBI:18403
name: L-arabinitol
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
initial amount: NaN

metaR GLUtr
type: Reaction
fast: false
reactant: MODEL1310110009#
name: intracellular transport
is described by: ECO:0000000
reversible: true
product: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, needed to transport glu-L out of ER in conversion of leuktrC4-> leuktrD4 NJ
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_82c2bf46_36ca_45a5_80df_2e6110ab1f04
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is: P47895
is encoded by: hsa:220
initial concentration: NaN
constant: false
name: ALDH1A3

metaR EX doco13ac
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_f684aedc_cdda_4adc_9f96_02a9fa9b54c0
initial amount: NaN
name: HSD17B10
is encoded by: hsa:3028
is: Q99714
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_f559912c_6c8a_4286_a052_31c78945feed
is encoded by: hsa:81539
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
name: SLC38A1
initial concentration: NaN
initial amount: NaN
type: Species
is: Q9H2H9

metaR GLCAASE8ly
is described by: ECO:0000269
type: Reaction
reversible: false
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
reactant: MODEL1310110009#
name: beta-glucuronidase, lysosomal
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.31
product: MODEL1310110009#
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_854d5378_6549_416a_ad2a_0c9271281944
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: LPGAT1
constant: false
initial concentration: NaN
is encoded by: hsa:9926
is: Q92604
boundary condition: true
type: Species

metaR C226CPT1
name: carnitine C22:6 transferase
type: Reaction
fast: false
kinetic law: MODEL1310110009#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
is: SBO:0000176
product: MODEL1310110009#

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_2efd7782_b15a_4078_bef6_07fff6225145
name: SLC29A1
initial concentration: NaN
is: Q99808
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:2030
is: SBO:0000252

metaR r0642
product: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
is: SBO:0000176
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
fast: false
is described by: ECO:0000000
reactant: MODEL1310110009#
type: Reaction
reversible: true

metaR FRDPtc
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
reactant: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
is: SBO:0000185

metaM hpdcacoa m
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB06497
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
name: heptadecanoyl coa

metaM asp L e
type: Species
is: HMDB00191
is: CHEBI:29991
boundary condition: false
constant: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: SBO:0000247
name: L-aspartate(1-)
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR C4x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of butyrylcoa to butyrylcarnitine for transport
type: Reaction

metaM hspg l
is: CHEBI:17899
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB01993
constant: false
is: SBO:0000247
type: Species
name: heparan sulfate proteoglycan
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_075189ec_cee5_4f35_8bac_ba48721797a6
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is: Q9H0P0
is encoded by: hsa:51251
name: NT5C3
has only substance units: false
boundary condition: true

metaM pydxn c
boundary condition: false
is: C00314
initial concentration: 1.0
has only substance units: false
is: HMDB00239
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:16709
type: Species
name: Pyridoxine
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314

metaR PIPLC
is version of: http://identifiers.org/ec-code/3.1.4.11
type: Reaction
modifier: MODEL1310110009#
reversible: false
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
kinetic law: MODEL1310110009#
is described by: ECO:0000000
name: phosphatidylinositol phospholipase C
product: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
is: SBO:0000176

metaM decdicrn e
is: HMDB13325
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C17H29NO4 CHARGE: 0
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
name: decadienoyl carnitine

metaM caro e
is: CHEBI:17579
is: SBO:0000247
type: Species
is: HMDB00561
name: beta-carotene
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false

metaM mag hs c
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
initial amount: NaN
is: CHEBI:16987
constant: false
boundary condition: false
name: monoacylglycerol 2
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB12130

metaR BILIRUBtr
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
product: MODEL1310110009#
is: SBO:0000185
reactant: MODEL1310110009#
reversible: true
kinetic law: MODEL1310110009#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_09fc271e_40ef_45fd_876c_786c0a7256b8
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: ALDH2
is encoded by: hsa:217
boundary condition: true
is: P05091

metaR RE0452M
product: MODEL1310110009#
name: RE0452
is described by: ECO:0000000
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
reversible: true
is: SBO:0000176
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_9bc0f094_8ba8_4c41_b862_7c7ba9cec805
constant: false
name: CHKB
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1120
type: Species
is: SBO:0000252
boundary condition: true
is: Q9Y259

metaM CE5114 x
boundary condition: false
initial amount: NaN
is: CHEBI:57923
constant: false
type: Species
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,20-21,28-30,34-36,40,51-52H,4-7,10,13,16-19,22-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,21-20+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE5114
is: SBO:0000247
name: trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA
initial concentration: 1.0

metaM abt c
initial amount: NaN
is: CHEBI:18403
is: SBO:0000247
is: HMDB01851
name: L-arabinitol
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532

http://identifiers.org/biomodels.db/MODEL1310110009#_ff3f8a7c_6a11_426c_af0d_534a762b55a4
has only substance units: false
is encoded by: hsa:10327
constant: false
is: P14550
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
name: AKR1A1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_9d619d52_576d_47cc_b101_c17a7b4bfd1d
name: MAN2A2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4122
initial amount: NaN
type: Species
has only substance units: false
is: Q9P1E4
constant: false
initial concentration: NaN

metaM 3ohdcoa m
name: 3-oxopalmitoyl-CoA(4-)
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB06402
type: Species
is: CHEBI:57349
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
boundary condition: false
initial concentration: 1.0

metaM CE5117 m
boundary condition: false
type: Species
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
initial concentration: 1.0
is: CHEBI:57923
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117

metaR r2309
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reversible: true
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110009#

metaM oxa m
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
constant: false
boundary condition: false
has only substance units: false
is: HMDB02329
is: SBO:0000247
name: oxalate(2-)
initial concentration: 1.0
is: CHEBI:30623
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_c95244b4_029c_4486_b43f_561aa8e19082
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10768
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
name: AHCYL1
constant: false

metaR RE0689E
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.22
product: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110009#
name: RE0689
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:

metaR NACHEX1ly
reversible: false
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110009#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
product: MODEL1310110009#

metaM fe2 c
constant: false
is: SBO:0000247
name: Fe2+
is: C00023
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:29033
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: HMDB00692
type: Species

metaR DSAT
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110009#
type: Reaction
name: dihydrosphingosine N-acyltransferase
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
product: MODEL1310110009#
is described by: ECO:0000000
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_8f9c479b_05ec_4b26_a388_dbdd4cf467fa
initial concentration: NaN
name: GCSH
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
type: Species
is encoded by: hsa:2653
is: P23434

metaR UMPK2n
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110009#
modifier: MODEL1310110009#
name: UMP kinase (CTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_8700d94c_464c_4654_a2a4_8509e35cec22
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000297
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial amount: NaN
is encoded by: hsa:515

metaM atp e
constant: false
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:57299
initial concentration: 1.0
is: HMDB00538
is: C00002
name: ATP(4-)
is: SBO:0000247
initial amount: NaN

metaM 6pgl r
is: HMDB01127
is: SBO:0000247
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
boundary condition: false
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: CHEBI:57955
initial amount: NaN

metaR RE2079R
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
is: SBO:0000176
product: MODEL1310110009#
reactant: MODEL1310110009#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
name: RE2079

metaR r2308
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110009#
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110009#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

http://identifiers.org/biomodels.db/MODEL1310110009#_f9c0b419_5fd6_4a6d_bbc7_a8b17ebb8d07
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6173
boundary condition: true
name: RPL36A
is: P83881
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_2d143005_5cc4_400b_9b63_cf1d1f0fd56c
is: SBO:0000252
is encoded by: hsa:NM 001929
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: true
initial concentration: NaN
name: _NM_001929_1_c

metaR SEBACIDTD
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacic acid into cytosol (diffusion)
type: Reaction

metaM 2hexdtricoa m
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: HMDB02288
constant: false
name: 2,7,10-hexadecatrienoylcoa

metaM dlnlcgcoa r
constant: false
is: C03595
type: Species
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
initial amount: NaN
is: CHEBI:27979
boundary condition: false
name: dihomo-gamma-linolenyl coenzyme A
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM spmd e
has only substance units: false
name: Spermidine
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
is: HMDB01257
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: CHEBI:57834
is: C00315
initial amount: NaN
boundary condition: false

metaR FAOXC205C184x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:4)x
type: Reaction

metaR BACCLm
reversible: false
type: Reaction
product: MODEL1310110009#
is: SBO:0000176
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.10
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000254

metaM hs deg10 l
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
initial amount: NaN
has only substance units: false
name: heparan sulfate, degradation product 10
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:15748
is: HMDB00127
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_a51deaff_81af_4ff9_84d7_fe282afdc759
is: SBO:0000252
initial concentration: NaN
type: Species
name: ALDH1B1
constant: false
has only substance units: false
is encoded by: hsa:219
boundary condition: true
is: P30837
initial amount: NaN

metaR AHCYStr
reversible: true
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
name: S-Adenosyl-L-homocysteine intracellular diffusion
product: MODEL1310110009#

metaM hdcea r
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
name: palmitoleate
is: CHEBI:32372
is: SBO:0000247
is: HMDB03229
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
constant: false

metaR ACGPID
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
is: SBO:0000176
fast: false
reactant: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
name: N-acetylglucosaminylphosphatidylinositol deacetylase
is version of: http://identifiers.org/ec-code/3.5.1.89

metaR A MANASEly
reactant: MODEL1310110009#
is: SBO:0000176
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.24
name: alpha-mannosidase, lysosomal
reversible: false
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
fast: false
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_90c9bf56_6129_4cdd_a4dc_e9b75bd8d63c
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:X63359
initial concentration: NaN
type: Species
boundary condition: true
name: _X63359_1_c
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_9bc2b308_5571_4663_b6dd_a370d5f29444
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:5151
boundary condition: true
initial concentration: NaN
name: PDE8A
is: SBO:0000252

metaR PEROXx
notes: GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ
name: peroxisomal lumped long chain fatty acid oxidation
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110009#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110009#
type: Reaction

metaR DMGDHm
fast: false
modifier: MODEL1310110009#
reactant: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.5.99.2
notes: GENE_ASSOCIATION: (29958.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10767172,PMID:1123190 NOTES:MM
kinetic law: MODEL1310110009#
name: dimethylglycine dehydrogenase, mitochondrial
is described by: ECO:0000269
type: Reaction

metaR PAPtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110009#
reactant: MODEL1310110009#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110009#
fast: false
is: SBO:0000185
name: adenosine 3',5'-bisphosphate Golgi transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_6fc07608_08ec_4431_a318_22f7ec572272
has only substance units: false
constant: false
is: Q9NS00
is: SBO:0000252
initial amount: NaN
name: C1GALT1
is encoded by: hsa:56913
type: Species
boundary condition: true
initial concentration: NaN

metaR PCm
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/6.4.1.1
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
name: pyruvate carboxylase
is: SBO:0000176
product: MODEL1310110009#
type: Reaction
fast: false
reversible: false

metaR H2O2t
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
is described by: ECO:0000000
name: hydrogen peroxide transport via diffusion
reactant: MODEL1310110009#
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110009#
product: MODEL1310110009#

metaR AG13T3g
fast: false
modifier: MODEL1310110009#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110009#
is: SBO:0000176
type: Reaction
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110009#
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_719f1542_a664_4ae2_ac9e_36e4d92e710d
is: Q6FGA0
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:9167
name: COX7A2L
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_712357c8_8fad_42a6_97a5_fa244d2a0090
has only substance units: false
initial amount: NaN
is encoded by: hsa:60490
is: Q96CD2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: PPCDC
constant: false
type: Species

metaM dmpp x
type: Species
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: prenyl diphosphate(3-)
boundary condition: false
initial concentration: 1.0
is: HMDB01120
constant: false
is: CHEBI:57623

metaM m8masn r
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: C05876
notes: FORMULA: C70H117N2O55X CHARGE: 0
type: Species
is: SBO:0000247
has only substance units: false

metaM atp c
boundary condition: false
initial concentration: 1.0
name: ATP(4-)
is: SBO:0000247
has only substance units: false
is: HMDB00538
is: C00002
initial amount: NaN
type: Species
is: CHEBI:30616
constant: false

metaM hspg e
is: HMDB02259
is: CHEBI:32366
is: SBO:0000247
constant: false
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: heparan sulfate proteoglycan
type: Species

metaM pe hs r
is: SBO:0000247
is: CHEBI:16038
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
name: phosphatidylethanolamine
boundary condition: false
has only substance units: false
type: Species
constant: false
initial concentration: 1.0

metaM o2s x
type: Species
name: superoxide
initial amount: NaN
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false
is: SBO:0000247
is: CHEBI:18421
constant: false
is: HMDB02168
initial concentration: 1.0
has only substance units: false

metaR SERDGLYexR
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
name: D-Serine/Glycine reversible exchange
product: MODEL1310110009#
type: Reaction
is described by: ECO:0000304

metaM tetdec2crn e
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: HMDB05066
name: tetradecadienoyl carnitine
notes: FORMULA: C21H37NO4 CHARGE: 0
is: SBO:0000247
has only substance units: false

metaM cdp c
is: HMDB01546
initial amount: NaN
name: CDP
has only substance units: false
type: Species
boundary condition: false
is: C00112
is: SBO:0000247
is: CHEBI:58069
constant: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_24f24169_b6a9_40d7_91b0_da3fe4e8d779
name: UGP2
is: SBO:0000252
type: Species
initial amount: NaN
is: Q16851
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:7360

metaM ksi pre35 g
is: SBO:0000247
boundary condition: false
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
initial amount: NaN
is: CHEBI:28067
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
name: keratan sulfate I biosynthesis, precursor 35

http://identifiers.org/biomodels.db/MODEL1310110009#_12d35c10_eef1_4751_bf6c_cf14f55867eb
constant: false
is: SBO:0000252
is: Q13907
name: IDI1
type: Species
is encoded by: hsa:3422
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM rib D c
boundary condition: false
is: HMDB00283
has only substance units: false
is: SBO:0000247
is: CHEBI:16988
type: Species
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
name: D-ribose
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_3df7d6c4_4dd0_40ec_91a6_1836b0b2db68
constant: false
has only substance units: false
boundary condition: true
name: ALDH4A1
type: Species
initial concentration: NaN
is encoded by: hsa:8659
initial amount: NaN
is: SBO:0000252

metaR G14T12g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
is described by: ECO:0000000
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
is: SBO:0000176
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
kinetic law: MODEL1310110009#
product: MODEL1310110009#

metaR r0660
is described by: ECO:0000000
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.5.1.2
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
modifier: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
fast: false
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110009#
is: SBO:0000176
reversible: true

metaR TCYNTt
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000185
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
fast: false
type: Reaction
name: Thiocyanate transport via diffusion (cytosol to extracellular)
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110009#_e15d6c98_2acf_44fd_9e5b_b727f58bd906
type: Species
name: MTMR3
has only substance units: false
is encoded by: hsa:8897
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR DESAT20 1
is: SBO:0000176
kinetic law: MODEL1310110009#
type: Reaction
reversible: false
reactant: MODEL1310110009#
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
fast: false
is described by: ECO:0000000
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_a3756ea3_9cdc_4429_b07e_36e261ceb948
initial amount: NaN
name: ACSL3
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:2181
constant: false
has only substance units: false
is: O95573
boundary condition: true

metaM bhb e
name: (R)-3-hydroxybutyrate
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
initial amount: NaN
boundary condition: false
is: CHEBI:10983
has only substance units: false
is: SBO:0000247
is: HMDB00011
initial concentration: 1.0
type: Species

metaM HC02202 c
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:57398
initial amount: NaN
name: prostaglandin A1(1-)

metaR LPS3e
type: Reaction
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.1.1.3
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110009#
name: lipase, extracellular
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_2775fdf3_300e_4c32_bc3e_8a757351a5ae
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: O95340
name: PAPSS2
is: SBO:0000252
is encoded by: hsa:9060

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_c361f48d_0765_4a10_bbe3_bbdae800aafc
boundary condition: true
initial concentration: NaN
is: Q9NST1
is: SBO:0000252
initial amount: NaN
name: PNPLA3
is encoded by: hsa:80339
constant: false
has only substance units: false
type: Species

metaR O2Stx
product: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
name: superoxide anion transport via diffusion (peroxisome)
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaM tetdec2crn c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB02014
boundary condition: false
constant: false
has only substance units: false
name: tetradecadienoyl carnitine
notes: FORMULA: C21H37NO4 CHARGE: 0
type: Species

metaR RE1233C
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.6.1.64
reactant: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
type: Reaction
name: RE1233
fast: false

metaR SO4HCOtex
reactant: MODEL1310110009#
name: sulfate transport via bicarbonate countertransport
is described by: ECO:0000304
kinetic law: MODEL1310110009#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (115111.1) or (115019.2) or (1836.1) or (115111.2) or (116369.2) or (284129.1) or (10861.2) or (116369.1) or (10861.1) or (10861.3) or (115019.1) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reversible: false
modifier: MODEL1310110009#
type: Reaction
product: MODEL1310110009#

metaM 4abut m
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
has only substance units: false
initial amount: NaN
is: CHEBI:16865
name: 4-Aminobutanoate
is: C00334
is: HMDB00112

metaM tsul m
boundary condition: false
is: CHEBI:16094
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
name: thiosulfate(2-)
is: HMDB00257
has only substance units: false
constant: false
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320

http://identifiers.org/biomodels.db/MODEL1310110009#_02433f27_a531_4a38_bc64_3875b45bc657
has only substance units: false
name: SLC37A4
constant: false
boundary condition: true
is: A8K0S7
initial amount: NaN
is encoded by: hsa:2542
initial concentration: NaN
type: Species
is: SBO:0000252

metaM frdp c
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
name: Farnesyl diphosphate
is: CHEBI:175763
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB00961
initial concentration: 1.0
is: C00448
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_cd15c327_c60a_4a06_877f_6d1486dbbbd5
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:771
is: O43570
name: CA12
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_a8cb1a22_be47_400c_8508_6e580c3bf9e7
has only substance units: false
is: SBO:0000252
is encoded by: hsa:29988
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
name: SLC2A8
boundary condition: true
is: Q9NY64

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

metaM HC02202 e
name: prostaglandin A1(1-)
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57398

metaM xol7ah2al m
boundary condition: false
initial concentration: 1.0
is: HMDB06894
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
type: Species
is: CHEBI:27428
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
constant: false
initial amount: NaN

metaM bhb c
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:10983
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: (R)-3-hydroxybutyrate
is: HMDB00011
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089

http://identifiers.org/biomodels.db/MODEL1310110009#_0c9fa023_f4d4_46f1_9d30_872af2e4a584
is: SBO:0000252
has only substance units: false
name: COX1
is: Q7GXY8
type: Species
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:4512

http://identifiers.org/biomodels.db/MODEL1310110009#_8b6af321_eade_4648_a4c0_86c34de15b1f
is: P16885
is: SBO:0000252
type: Species
is encoded by: hsa:5336
name: PLCG2
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN

metaM eitetcoa m
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: 5,8,11,14-eicosatetraenoylcoa
initial amount: NaN
constant: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
type: Species
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247

metaR SCP22x
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.176
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
product: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000000
name: Sterol carrier protein 2
reversible: true
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_6d365cd1_26d6_4d16_8ca5_93b4e299ab6c
name: ATP5G3
type: Species
has only substance units: false
constant: false
is encoded by: hsa:518
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM ksi deg21 l
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:12936
boundary condition: false
has only substance units: false
name: keratan sulfate I, degradation product 21
is: HMDB00143
type: Species
notes: FORMULA: C132H213N9O114S6 CHARGE: -6

metaR r0661
reversible: false
kinetic law: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
fast: false

metaR FPGS4m
fast: false
name: folylpolyglutamate synthetase (DHF), mitochondrial
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
is version of: http://identifiers.org/ec-code/6.3.2.17
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110009#
is: SBO:0000176
reactant: MODEL1310110009#
reversible: false
product: MODEL1310110009#
kinetic law: MODEL1310110009#

metaR DPCOAPPe
reversible: false
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110009#
name: Pyrophasphatase (dephospho-CoA, extracellular)
type: Reaction
is: SBO:0000176
reactant: MODEL1310110009#
product: MODEL1310110009#

metaR FAS160COA
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
name: fatty-acyl-CoA synthase (n-C16:0CoA)
modifier: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
is described by: ECO:0000269
fast: false

metaM lac D e
has only substance units: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
name: (R)-lactate
initial concentration: 1.0
is: CHEBI:16004
is: HMDB01311
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR MTHFC
product: MODEL1310110009#
is: SBO:0000176
name: methenyltetrahydrofolate cyclohydrolase
is version of: http://identifiers.org/ec-code/3.5.4.9
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: true
fast: false
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.5.1.5

http://identifiers.org/biomodels.db/MODEL1310110009#_d2cf53f9_aedf_40b5_9281_f3969b824bfc
constant: false
name: PANK2
initial amount: NaN
is encoded by: hsa:80025
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species

metaR r0941
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110009#
fast: false
product: MODEL1310110009#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110009#
reversible: true
name: Free diffusion

metaM HC00319 c
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
is: SBO:0000247
name: Malonate
initial amount: NaN
is: CHEBI:30794
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_019105ae_43cc_48df_8341_6dcc44f233b4
is encoded by: hsa:91734
is: Q9BXS1
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: IDI2
type: Species
constant: false
has only substance units: false
initial concentration: NaN

metaM HC01603 c
type: Species
is: C00234
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0
name: 10-Formyltetrahydrofolate
boundary condition: false
is: SBO:0000247

metaR DOLMANP Uter
reversible: false
fast: false
kinetic law: MODEL1310110009#
name: dolichol-phosphate mannose flippase (uterus)
reactant: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaM dag hs c
type: Species
initial amount: NaN
constant: false
is: CHEBI:18035
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: diglyceride

metaR UGCG
fast: false
product: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.80
type: Reaction
name: Ceramide glucosyltransferase
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ

metaR ENGASE2ly
reactant: MODEL1310110009#
reversible: false
name: endo-beta-N-acetylglucosaminidase, lysosomal
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110009#
is described by: ECO:0000000
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_bfc4bc62_58ac_4702_a0a2_4dc708b94496
boundary condition: true
is encoded by: hsa:AI373818
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
name: _AI373818_1_m
has only substance units: false

metaR FAOXC150m
name: Beta oxidation of long chain fatty acid (odd chain)
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
reactant: MODEL1310110009#
is: SBO:0000176
modifier: MODEL1310110009#
fast: false
product: MODEL1310110009#
kinetic law: MODEL1310110009#

metaR r0940
kinetic law: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reversible: true
name: Free diffusion
reactant: MODEL1310110009#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110009#_6a7de328_4da8_4a13_92a3_6e745419f6db
is: SBO:0000297
constant: false
has only substance units: false
is encoded by: hsa:4830
name: NME1:NME2
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_bb347adc_b163_4551_99eb_12ea94f89b9f
name: PIP5K1B
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: O14986
constant: false
is encoded by: hsa:8395

metaM o2s n
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
name: superoxide
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
has only substance units: false
is: HMDB02168
is: CHEBI:18421

metaR ARAB Lt
reactant: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: L-arabinoase extracellular transport
type: Reaction

metaM atp m
is: CHEBI:57299
initial concentration: 1.0
initial amount: NaN
name: ATP(4-)
boundary condition: false
is: HMDB00538
is: C00002
has only substance units: false
is: SBO:0000247
constant: false
type: Species

metaM 3mob c
is: CHEBI:11851
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
name: 3-methyl-2-oxobutanoate
boundary condition: false

metaM lac D c
is: SBO:0000247
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
name: (R)-lactate
initial concentration: 1.0
is: CHEBI:16004
boundary condition: false
type: Species
is: HMDB01311
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_82630acc_4add_4064_a4e6_53b7c68e4cae
initial amount: NaN
initial concentration: NaN
name: ALG12
constant: false
is encoded by: hsa:79087
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q9BV10

metaM CE4790 m
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
is: CHEBI:57923
constant: false

metaR r0208
reactant: MODEL1310110009#
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110009#
fast: false
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
is version of: http://identifiers.org/ec-code/4.4.1.1
product: MODEL1310110009#
kinetic law: MODEL1310110009#

metaM C05965 e
initial concentration: 1.0
is: CHEBI:57444
has only substance units: false
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
is: HMDB04243
is: SBO:0000247
type: Species
constant: false
name: 12(S)-HPETE(1-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_32a69516_356b_402e_8dd7_2c029bb4080d
is: P23919
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: DTYMK
type: Species
is encoded by: hsa:1841
constant: false
initial concentration: NaN
has only substance units: false

metaR q10tm
kinetic law: MODEL1310110009#
product: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
name: transport of ubiquinone into mitochondria
reversible: true
reactant: MODEL1310110009#
type: Reaction
is: SBO:0000185

metaR PHCDm
modifier: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
fast: false
kinetic law: MODEL1310110009#
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
is: SBO:0000176
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.5.1.12
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110009#_8dc086a4_bf8b_4a65_ac74_fdd8057f9fa9
is: P30825
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
name: SLC7A1
type: Species
initial concentration: NaN
is encoded by: hsa:6541
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_e20a32ba_a3ee_4d61_8857_de5d6523b408
is: SBO:0000252
name: SLC29A2
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:3177
type: Species
initial concentration: NaN
is: Q14542

metaR DUDPtn
reversible: true
reactant: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110009#
fast: false
product: MODEL1310110009#
name: dUDP nuclear transport
type: Reaction

metaM HC00250 e
initial amount: NaN
is: CHEBI:29919
name: hydrosulfide
boundary condition: false
is: SBO:0000247
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
constant: false
type: Species
has only substance units: false
initial concentration: 1.0

metaR FAOXC123m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_f5edf889_6507_4c7f_bc53_146044fffb0f
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
has only substance units: false
name: CTPS1
is encoded by: hsa:1503
is: P17812
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_5eb0edaf_57f9_4998_9746_9433ab3a07e6
name: SLC19A3
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:80704
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q9BZV2

metaR URIt
reversible: true
product: MODEL1310110009#
kinetic law: MODEL1310110009#
name: uridine facilated transport in cytosol
fast: false
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
modifier: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction

metaM Rtotal2coa c
has only substance units: false
is: CHEBI:57876
boundary condition: false
name: R total 2 coenzyme A
is: HMDB01564
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110009#_1527052e_40b7_4781_b99c_823a55cc2680
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4831
name: NME1:NME2
has part: P22392
is encoded by: hsa:4830
has only substance units: false
has part: P15531
initial amount: NaN
type: Species
is: SBO:0000297

metaM idour c
type: Species
is: SBO:0000247
is: CHEBI:21338
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
constant: false
is: HMDB02704
name: L-iduronate
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_361be8be_07d4_4a0f_8586_0e8cc6e38862
constant: false
is encoded by: hsa:276
initial concentration: NaN
initial amount: NaN
type: Species
is: Q6NSB3
is: SBO:0000252
boundary condition: true
name: AMY1A
has only substance units: false

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_1900ef21_bf24_4472_be29_c7c0f5a0c80f
constant: false
type: Species
has only substance units: false
name: _PRO1933_1_m
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:PRO1933

http://identifiers.org/biomodels.db/MODEL1310110009#_e3baf35d_713c_4c68_a657_9beec1bc701e
is: SBO:0000252
has only substance units: false
name: AMACR
initial concentration: NaN
initial amount: NaN
is: Q9UHK6
constant: false
type: Species
is encoded by: hsa:23600
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_1200e924_88d9_40f9_86c4_d305bab20775
is encoded by: hsa:5152
has only substance units: false
type: Species
initial concentration: NaN
constant: false
name: PDE9A
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM 4abut c
name: 4-Aminobutanoate
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0
is: HMDB00112
constant: false
is: SBO:0000247
is: CHEBI:3628
initial concentration: 1.0
is: C00334
type: Species
has only substance units: false

metaM retn c
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: CHEBI:35291
is: HMDB01852
name: all-trans-retinoate
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false

metaM ksii core4 pre5 g
is: SBO:0000247
is: CHEBI:58053
has only substance units: false
is: HMDB00175
initial amount: NaN
boundary condition: false
is: C00130
notes: FORMULA: C69H112N6O48X CHARGE: -1
initial concentration: 1.0
constant: false
name: keratan sulfate II biosynthesis, precursor 5
type: Species

metaR LTD4DP
name: Leukotriene D4 dipeptidase
fast: false
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
kinetic law: MODEL1310110009#
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110009#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110009#_1ac5f49c_d567_4812_885e_c7f417978b03
has only substance units: false
initial amount: NaN
is encoded by: hsa:270
constant: false
is: P23109
name: AMPD1
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaR S6T12g
modifier: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: false
type: Reaction
reactant: MODEL1310110009#
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110009#_4cad3024_8e42_483a_a0f0_45005d218d7f
name: NME1:NME2
boundary condition: true
has part: P15531
is: SBO:0000297
constant: false
is encoded by: hsa:4831
has part: P22392
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4830
type: Species
has only substance units: false

metaR TYMSULT
kinetic law: MODEL1310110009#
type: Reaction
modifier: MODEL1310110009#
reversible: false
product: MODEL1310110009#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.8.2.1
fast: false
reactant: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
name: Tyramine Sulfotransferase

http://identifiers.org/biomodels.db/MODEL1310110009#_05a90333_407c_4faf_99e0_0fc9340850a4
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:23396
name: PIP5K1C
is: O60331
boundary condition: true
initial concentration: NaN

metaR 3HLYTCL
reversible: false
product: MODEL1310110009#
is: SBO:0000176
name: 3-Hydroxy-L-tyrosine carboxy-lyase
fast: false
reactant: MODEL1310110009#
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/4.1.1.28
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110009#

metaM 2dodtricoa m
is: C05279
is: HMDB11123
name: 2,6,9-dodecatrienoylcoa
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR CERT1gt
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
reactant: MODEL1310110009#
name: ceramide transport protein
type: Reaction
product: MODEL1310110009#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000185
fast: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide

metaR FAOXC226C205m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_9c86eca3_2085_4e84_abaf_c89dde8670d4
has only substance units: false
is: SBO:0000252
is encoded by: hsa:492
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: Q16720
name: ATP2B3
type: Species

metaM c10crn e
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00651
name: decanoyl carnitine
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C17H33NO4 CHARGE: 0
type: Species

metaR r0944
is described by: ECO:0000000
kinetic law: MODEL1310110009#
fast: false
product: MODEL1310110009#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
reactant: MODEL1310110009#
is: SBO:0000185
name: Active transport

http://identifiers.org/biomodels.db/MODEL1310110009#_1191b347_7620_480e_b3a3_e1a30b38cd30
is: P11168
name: SLC2A2
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:6514
has only substance units: false
constant: false
is: SBO:0000252

metaM bhb m
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
boundary condition: false
type: Species
is: HMDB00011
name: (R)-3-hydroxybutyrate
constant: false
is: CHEBI:10983
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_43e4e14e_55fc_4e6d_920c_893ed890190d
is: SBO:0000252
boundary condition: true
name: MSMO1
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:6307
is: A8MYF6
has only substance units: false

metaR RE1532M
name: RE1532
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
product: MODEL1310110009#
modifier: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_67b84914_930b_439f_a952_d501f902cf1e
type: Species
boundary condition: true
constant: false
has only substance units: false
is: Q14432
name: PDE3A
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5139
initial concentration: NaN

metaR GALASE19ly
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110009#
reactant: MODEL1310110009#
name: beta-galactosidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_0e98137e_a268_45f4_bc4f_94ce9790877e
initial concentration: NaN
is: Q0VAA5
constant: false
type: Species
has only substance units: false
is encoded by: hsa:257068
initial amount: NaN
name: PLCXD2
boundary condition: true
is: SBO:0000252

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaM succ m
has only substance units: false
is: C00042
boundary condition: false
initial concentration: 1.0
is: CHEBI:30031
is: HMDB00254
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
type: Species
name: Succinate
constant: false

metaM C05280 m
name: cis,cis-3,6-Dodecadienoyl-CoA
boundary condition: false
type: Species
constant: false
is: HMDB03952
is: CHEBI:28002
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR 5OXPROt
type: Reaction
reactant: MODEL1310110009#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
name: Transport of 5-oxoprolinate

http://identifiers.org/biomodels.db/MODEL1310110009#_21f6fcfd_87bf_4b04_8f23_24ede08350fa
is encoded by: hsa:1719
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
name: DHFR
is: P00374
type: Species

metaR RAI1
type: Reaction
fast: false
name: retinal isomerase (11-cis)
reactant: MODEL1310110009#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
product: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110009#_c7fe9b46_2fb9_4631_883e_6b960c7b630a
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has only substance units: false
constant: false
is: SBO:0000297
initial concentration: NaN
has part: Q6IB54
is encoded by: hsa:522
type: Species
boundary condition: true
initial amount: NaN

metaM 4abut e
has only substance units: false
initial amount: NaN
boundary condition: false
name: 4-Aminobutanoate
is: HMDB00112
constant: false
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0
is: CHEBI:3628
is: C00334
type: Species
initial concentration: 1.0

metaR ACOAD1fm
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
reactant: MODEL1310110009#
is described by: ECO:0000269
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM o2s m
type: Species
initial amount: NaN
is: C00704
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: Superoxide anion
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: HMDB02168
is: CHEBI:18421

metaR GLCURtly
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185
modifier: MODEL1310110009#
reversible: true
type: Reaction
is described by: ECO:0000269
name: glucuronate transport into lysososme
product: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD

metaR GLCNACPT U
is described by: ECO:0000000
modifier: MODEL1310110009#
reversible: false
type: Reaction
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110009#
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.15
is: SBO:0000176
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (uterus)
reactant: MODEL1310110009#

metaR PGLer
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.47
is: SBO:0000176
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
is described by: ECO:0000269
reversible: false
type: Reaction
name: 6-phosphogluconolactonase, endoplasmic reticulum
product: MODEL1310110009#
reactant: MODEL1310110009#

metaM tsul e
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
has only substance units: false
is: HMDB00257
constant: false
initial amount: NaN
name: thiosulfate(2-)
initial concentration: 1.0
is: CHEBI:16094
type: Species
boundary condition: false
is: SBO:0000247

metaR HEX10
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000212
is: SBO:0000176
product: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.2
name: hexokinase (D-glucosamine:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.1
fast: false
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110009#_04693bc3_b8d4_4b5a_89eb_63a6cf08c079
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
is: Q9NYW8
has only substance units: false
is encoded by: hsa:57786
name: RBAK
constant: false

metaR FRDPtr
name: lipid, flip-flop intracellular transport
is: SBO:0000185
reactant: MODEL1310110009#
reversible: true
product: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
type: Reaction
kinetic law: MODEL1310110009#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_cc10d71f_b7bf_4cef_b3ca_c54c852c9242
type: Species
is: Q5SPY7
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
name: ENTPD2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:954

metaM c10crn c
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00651
boundary condition: false
type: Species
name: decanoyl carnitine
initial amount: NaN
notes: FORMULA: C17H33NO4 CHARGE: 0
constant: false

metaR DOLPGT2 Uer
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
reversible: false
is: SBO:0000176
type: Reaction
product: MODEL1310110009#
modifier: MODEL1310110009#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
is version of: http://identifiers.org/ec-code/2.4.1.265
is described by: ECO:0000000
fast: false
reactant: MODEL1310110009#

metaR r0942
is described by: ECO:0000000
product: MODEL1310110009#
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110009#
is: SBO:0000185
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:

metaR RAI2
name: retinal isomerase (9-cis)
kinetic law: MODEL1310110009#
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_58a0ac2c_705d_42ea_a715_2db6b0fe45a1
initial amount: NaN
is encoded by: hsa:9162
is: SBO:0000252
has only substance units: false
name: DGKI
boundary condition: true
initial concentration: NaN
is: O75912
constant: false
type: Species

metaR NACHEX16ly
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110009#
is: SBO:0000176
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110009#
reversible: false
type: Reaction
is described by: ECO:0000000
fast: false
modifier: MODEL1310110009#

metaR O2Stn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reactant: MODEL1310110009#
name: superoxide anion transport via diffusion (nucleus)
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_c739f46c_7c87_4de5_ab83_ad0ea3f47f1b
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:AI620219
initial amount: NaN
name: _AI620219_1_m
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_9ceb798b_726c_4bb4_8ba7_be83876c4282
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:125
type: Species
initial amount: NaN
is: P00325
name: ADH1B
initial concentration: NaN

metaR G5SADrm
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
is: SBO:0000176
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
reversible: true
reactant: MODEL1310110009#
fast: false

metaM so4 m
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false
type: Species
is: CHEBI:16189
has only substance units: false
initial concentration: 1.0
name: sulfate
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB01448

http://identifiers.org/biomodels.db/MODEL1310110009#_36f2f001_a69f_4fea_945d_a561baf7d6b7
name: SDHD
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is: O14521
is encoded by: hsa:6392
initial amount: NaN
initial concentration: NaN
type: Species

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaR RE2996X
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.34
kinetic law: MODEL1310110009#
product: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (26063.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE2996
modifier: MODEL1310110009#
is described by: ECO:0000000

metaR NRVNCt
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
is: SBO:0000185
product: MODEL1310110009#
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaR GLYCt
reversible: true
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110009#
product: MODEL1310110009#
name: glycerol transport via channel
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD

metaR ARACHDt2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
product: MODEL1310110009#
name: fatty acid transport via diffusion
kinetic law: MODEL1310110009#
is: SBO:0000185
fast: false
reactant: MODEL1310110009#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_9fa20fb3_e47b_4b5d_9dd0_73bfc8006b6d
type: Species
has part: P37287
initial concentration: NaN
initial amount: NaN
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
constant: false
is: SBO:0000297
is encoded by: hsa:8818
boundary condition: true
is encoded by: hsa:5277
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_f04a1c05_6cb1_4af2_a7ae_57acce422d2e
constant: false
type: Species
is encoded by: hsa:57835
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: SLC4A5
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_5f2e65e4_85e5_4aa0_9ab4_7dab916b9a61
initial concentration: NaN
constant: false
type: Species
name: SLC2A3
is: P11169
initial amount: NaN
is encoded by: hsa:6515
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR PROSTGF2t
modifier: MODEL1310110009#
reversible: true
kinetic law: MODEL1310110009#
is described by: ECO:0000269
name: prostaglandin uniport
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110009#
type: Reaction
product: MODEL1310110009#

metaM tsul c
is: SBO:0000247
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: CHEBI:16094
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
name: thiosulfate(2-)
boundary condition: false
constant: false
is: HMDB00257

http://identifiers.org/biomodels.db/MODEL1310110009#_ef57172d_0a33_4ad5_87ad_66c516cf7521
is: SBO:0000252
is encoded by: hsa:9563
is: O95479
initial concentration: NaN
name: H6PD
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_d75db904_ff36_49dc_a0d3_a6860502eeb2
name: PEMT
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10400

metaM pe hs e
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
name: phosphatidylethanolamine
is: CHEBI:16038

metaR ALOX5
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe
is described by: ECO:0000269
name: Arachidonate 5-lipoxygenase
reversible: false
product: MODEL1310110009#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.34
type: Reaction
reactant: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#

metaM paps c
has only substance units: false
initial concentration: 1.0
is: CHEBI:58339
is: SBO:0000247
initial amount: NaN
is: HMDB01134
constant: false
boundary condition: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
type: Species
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053

metaR r1893
type: Reaction
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110009#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110009#
is: SBO:0000185
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110009#
reversible: false

metaM drib c
type: Species
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
is: SBO:0000247
is: CHEBI:28816
boundary condition: false
is: HMDB03224
has only substance units: false
initial concentration: 1.0
name: 2-deoxy-D-ribose
constant: false
initial amount: NaN

metaM cdp n
is: SBO:0000247
initial concentration: 1.0
is: HMDB01546
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
constant: false
is: CHEBI:58069
name: CDP(3-)
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_0aa1a088_130e_4265_a43e_2ac06c779d74
is encoded by: hsa:5290
has only substance units: false
is: P42336
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: PIK3CA

http://identifiers.org/biomodels.db/MODEL1310110009#_f77ea204_358a_4e25_9584_7d681ea8d8ae
constant: false
name: _AA629629_1_m
type: Species
initial concentration: NaN
is encoded by: hsa:AA629629
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM dag hs n
boundary condition: false
is: CHEBI:18035
name: diglyceride
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
initial amount: NaN

metaM r1p c
boundary condition: false
initial concentration: 1.0
is: CHEBI:57720
initial amount: NaN
is: HMDB01489
is: SBO:0000247
is: C00442
type: Species
constant: false
has only substance units: false
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
name: alpha-D-Ribose 1-phosphate

metaR PI4P3K
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.153
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.1.154
type: Reaction
is described by: ECO:0000000
fast: false
name: phosphatidylinositol 4-phosphate 3-kinase
reactant: MODEL1310110009#
is: SBO:0000176

metaR S23T3g
reversible: false
modifier: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
kinetic law: MODEL1310110009#
fast: false
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.99.6

http://identifiers.org/biomodels.db/MODEL1310110009#_ca36fbdf_7872_4d64_81ad_4215198959f6
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
name: _H53099_1_m
is encoded by: hsa:H53099
is: SBO:0000252

metaR FORt2m
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD,IT
type: Reaction
product: MODEL1310110009#
reversible: true
fast: false
is described by: ECO:0000000
name: formate mitochondrial transport
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000185

metaM 6dhf e
type: Species
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
name: hexaglutamyl folate (DHF)
is: SBO:0000247
initial concentration: 1.0
is: HMDB06563
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false

metaM HC01405 m
constant: false
type: Species
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
is: SBO:0000247
initial amount: NaN
is: CHEBI:28632
has only substance units: false
initial concentration: 1.0
name: (S)-Hydroxyoctanoyl-CoA
boundary condition: false

metaR L LACt2r
type: Reaction
fast: false
product: MODEL1310110009#
name: L-lactate reversible transport via proton symport
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
is: SBO:0000185
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#

metaR r0946
kinetic law: MODEL1310110009#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110009#
reversible: true
product: MODEL1310110009#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR FAOXC226C227m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

metaM so4 l
name: sulfate
initial amount: NaN
is: SBO:0000247
is: HMDB01448
is: CHEBI:16189
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaR r1895
product: MODEL1310110009#
reversible: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110009#
type: Reaction

metaM atp r
is: HMDB00538
type: Species
constant: false
initial amount: NaN
is: CHEBI:57299
boundary condition: false
is: SBO:0000247
has only substance units: false
name: ATP(4-)
initial concentration: 1.0
is: C00002

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

metaM pe hs c
is: CHEBI:16038
name: phosphatidylethanolamine
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false

metaR C12DCTD
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Dodecanedioic acid by diffusion
type: Reaction

metaM f6p c
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3385
is: C00085
constant: false
is: CHEBI:57579
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
name: D-Fructose 6-phosphate
is: HMDB00124

metaM drib e
is: SBO:0000247
type: Species
is: CHEBI:28816
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
is: HMDB03224
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: 2-deoxy-D-ribose
has only substance units: false

metaR NDPK3n
type: Reaction
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
product: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110009#
reversible: true
fast: false

metaR RTOTAL2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
name: RTOTAL2 transport
fast: false
is: SBO:0000185
product: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reversible: true

metaM idour e
name: L-iduronate
constant: false
boundary condition: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial concentration: 1.0
has only substance units: false
is: CHEBI:21338
type: Species
initial amount: NaN
is: HMDB02704
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_b04424d0_42d6_4122_aa21_b9a8b5ced9d6
initial amount: NaN
is encoded by: hsa:30833
name: NT5C
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q8TCD5
has only substance units: false
boundary condition: true
constant: false

metaR RDH2a
fast: false
is: SBO:0000176
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.105
product: MODEL1310110009#
reactant: MODEL1310110009#
modifier: MODEL1310110009#
name: retinol dehydrogenase (9-cis,NADPH)
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.300
type: Reaction

metaM g3m8masn r
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C88H147N2O70X CHARGE: 0
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
is: C05873
boundary condition: false

metaR FAOXC205C185m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_3680bcf4_747b_4dac_b5bd_ab7bb1010ce4
constant: false
is: O43451
is encoded by: hsa:8972
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
name: MGAM
initial amount: NaN

metaM lpam m
name: lipoamide
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00962
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:17460
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248

metaR SQLEr
type: Reaction
name: Squalene epoxidase, endoplasmic reticular (NADP)
is: SBO:0000176
product: MODEL1310110009#
is described by: ECO:0000134
modifier: MODEL1310110009#
reversible: false
is version of: http://identifiers.org/ec-code/1.14.13.132
reactant: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
kinetic law: MODEL1310110009#

metaM imp c
is: C00130
name: IMP
constant: false
type: Species
is: HMDB00175
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: CHEBI:58053
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR ALOX52
kinetic law: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
fast: false
is: SBO:0000176
reactant: MODEL1310110009#
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.13.11.34
name: Arachidonate 5-lipoxygenase
reversible: false

metaM HC00250 c
constant: false
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:29919
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
name: hydrosulfide
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR HIVCRNe
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-isovaleryl carnitine into extra cellular space
type: Reaction

metaM 2hexdtricoa x
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB02288
name: 2,7,10-hexadecatrienoylcoa
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR EX glygn5 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 5 (glycogenin-2[1,4-Glc])
type: Reaction

metaM CE5125 x
is: HMDB00127
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5125
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:15748
type: Species
initial concentration: 1.0
name: (2S)-pristanoyl-CoA

metaR CYSASNNaEx
reactant: MODEL1310110009#
fast: false
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000269
reversible: false
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_5d512553_42ea_4bce_b549_6ce5a86703a4
boundary condition: true
has only substance units: false
is: P14618
name: PKM2
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:5315
is: SBO:0000252
constant: false

metaR FAOXC4C4DCc
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: succ-->C4DCc
type: Reaction

metaM succ c
initial amount: NaN
is: C00042
has only substance units: false
type: Species
is: CHEBI:30031
is: HMDB00254
constant: false
boundary condition: false
name: Succinate
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_706122dc_8dfe_4642_b6da_4bc3b578826a
boundary condition: true
is encoded by: hsa:2181
initial amount: NaN
type: Species
is: B3KMA6
has only substance units: false
initial concentration: NaN
name: ACSL3
is: SBO:0000252
constant: false

metaM 10fthf5glu e
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:58190
name: 10-formyltetrahydrofolate-[Glu](5)
has only substance units: false
is: HMDB00224
type: Species
initial concentration: 1.0
notes: FORMULA: C40H45N11O19 CHARGE: -6
initial amount: NaN

metaM 3mob e
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: SBO:0000247
is: HMDB00019
has only substance units: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
is: CHEBI:11851
initial amount: NaN
name: 3-methyl-2-oxobutanoate

metaR r2310
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110009#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110009#
is: SBO:0000185

metaM trdrd m
type: Species
is: SBO:0000247
is: CHEBI:15967
constant: false
name: Reduced thioredoxin
initial amount: NaN
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
boundary condition: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_8195dd32_f47f_4ae7_a989_26d782cf4b04
is: SBO:0000252
initial concentration: NaN
name: NMNAT3
initial amount: NaN
boundary condition: true
type: Species
is: Q96T66
has only substance units: false
is encoded by: hsa:349565
constant: false

metaM frdp r
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
type: Species
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:175763
is: HMDB00961
is: C00448
initial amount: NaN
name: Farnesyl diphosphate
initial concentration: 1.0

metaM ru5p D r
initial amount: NaN
has only substance units: false
is: CHEBI:58121
is: SBO:0000247
type: Species
constant: false
is: HMDB00618
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
name: D-ribulose 5-phosphate(2-)
boundary condition: false
initial concentration: 1.0

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaR GTHRDt
reversible: true
name: Glutathione transport into mitochondria
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
type: Reaction
is: SBO:0000185
reactant: MODEL1310110009#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110009#

metaR FAOXC122x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)x
type: Reaction

metaM dtmp c
has only substance units: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: CHEBI:26999
is: HMDB01227
initial amount: NaN
boundary condition: false
is: C00364
constant: false
type: Species
name: dTMP
is: SBO:0000247
initial concentration: 1.0

metaR r0801
fast: false
is: SBO:0000185
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_12248034_c0a2_4e10_950f_7fac629c9c0f
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: _R51273_1_c
type: Species
constant: false
is encoded by: hsa:R51273

metaM atp n
type: Species
name: ATP(3-)
constant: false
is: SBO:0000247
is: HMDB00538
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:57299

metaM imp e
constant: false
name: IMP(2-)
is: HMDB00175
type: Species
is: CHEBI:58053
initial amount: NaN
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR r2311
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110009#

metaR RE3269C
fast: false
modifier: MODEL1310110009#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.48
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
reversible: true
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
name: RE3269
type: Reaction
product: MODEL1310110009#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110009#_c15b63b7_c215_4b07_9563_ab03465f7cf6
constant: false
is encoded by: hsa:7167
initial amount: NaN
type: Species
name: TPI1
is: Q53HE2
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_033308df_da62_42ad_ac6a_4e51e92777ae
name: ATP5A1
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: B4DY56
has only substance units: false
is encoded by: hsa:498

metaR HDCEAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110009#
is described by: ECO:0000000
name: fatty acid transport via diffusion
reversible: true
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110009#
reactant: MODEL1310110009#

metaR LEUKTRA4t
kinetic law: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
name: leukotriene A4 transport
product: MODEL1310110009#
fast: false
is described by: ECO:0000269

metaM oxa c
is: CHEBI:30623
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB02329
initial amount: NaN
name: oxalate(2-)
is: SBO:0000247
type: Species

metaM succ e
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
boundary condition: false
is: HMDB00254
type: Species
initial amount: NaN
name: succinate(2-)
constant: false
initial concentration: 1.0
is: CHEBI:30031
has only substance units: false
is: SBO:0000247

metaR MTHFDm
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.5.4.9
modifier: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.3
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110009#
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
fast: false
reversible: true

metaM eitetcoa x
is: SBO:0000247
name: 5,8,11,14-eicosatetraenoylcoa
type: Species
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790

metaR NADPtxu
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110009#
reversible: false
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ potential for free H NJ
name: NADP transporter, peroxisome
product: MODEL1310110009#
is: SBO:0000185
type: Reaction

metaM so4 e
has only substance units: false
name: sulfate
is: HMDB01448
is: SBO:0000247
is: CHEBI:16189
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false

metaM ru5p D c
is: HMDB00618
has only substance units: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
type: Species
is: CHEBI:58121
boundary condition: false
constant: false
name: D-ribulose 5-phosphate(2-)
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR MAL Lte
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
is: SBO:0000185
name: Transport of L-malate
kinetic law: MODEL1310110009#
is described by: ECO:0000134
reversible: true
type: Reaction
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_6bd1fcff_50ab_4ed2_a585_5d07b42600c8
initial amount: NaN
initial concentration: NaN
name: PGK2
is encoded by: hsa:5232
type: Species
boundary condition: true
is: SBO:0000252
is: P07205
has only substance units: false
constant: false

metaR r0651
is version of: http://identifiers.org/ec-code/1.5.1.2
type: Reaction
is: SBO:0000176
reversible: true
product: MODEL1310110009#
modifier: MODEL1310110009#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#

metaM ksi deg40 l
is: HMDB00143
initial concentration: 1.0
name: keratan sulfate I, degradation product 40
constant: false
notes: FORMULA: C40H68N2O31 CHARGE: 0
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:12936
initial amount: NaN
is: SBO:0000247

metaM xol7ah2al c
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
constant: false
is: CHEBI:27428
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB06894

metaM anth c
initial amount: NaN
type: Species
is: SBO:0000247
name: anthranilate
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
constant: false
is: CHEBI:16567
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB01123

http://identifiers.org/biomodels.db/MODEL1310110009#_ac9abdd1_a75c_4abd_83b1_100efda03e69
has only substance units: false
is: P04843
is encoded by: hsa:6184
is: SBO:0000252
name: RPN1
constant: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN

metaR r2312
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
product: MODEL1310110009#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_76eb7809_61fd_44f2_830f_50f8d6fab8c6
constant: false
is: G3XA95
type: Species
name: PPAP2A
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:8611
has only substance units: false

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaM 2dodtricoa x
has only substance units: false
is: HMDB11123
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
name: 2,6,9-dodecatrienoylcoa
is: C05279

metaR r1781
fast: false
modifier: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110009#
name: Y+LAT2 Utilized transport
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110009#_884b3993_fc1b_41af_8d7d_29a2f88af861
is: SBO:0000252
name: AUH
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:549
initial concentration: NaN
is: Q13825
has only substance units: false
boundary condition: true

metaM fuc1p L c
has only substance units: false
boundary condition: false
is: HMDB01265
name: L-Fucose 1-phosphate
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
initial amount: NaN
is: CHEBI:28319
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR r0652
type: Reaction
fast: false
is: SBO:0000176
reversible: true
product: MODEL1310110009#
is described by: ECO:0000000
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.2
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
modifier: MODEL1310110009#

metaM pe hs m
name: phosphatidylethanolamine
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
type: Species
is: CHEBI:16038
constant: false
boundary condition: false
has only substance units: false

metaR PCt
is: SBO:0000185
name: phosphatidylcholine transporter
kinetic law: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ
is version of: http://identifiers.org/ec-code/3.6.3.44
fast: false
reversible: true
reactant: MODEL1310110009#
is described by: ECO:0000269
modifier: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_884d04b9_f36a_4e79_8447_af92b1352a8b
boundary condition: true
name: HSD17B4
is: E9PB82
has only substance units: false
is encoded by: hsa:3295
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species

metaR r2313
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000185
product: MODEL1310110009#
reversible: true
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_79cef9b9_a1c9_4f5f_9cc6_821b98388356
name: TPH2
type: Species
initial amount: NaN
boundary condition: true
is: Q8IWU9
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:121278

metaR DESAT22 2p
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
reversible: false
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110009#
is: SBO:0000176
type: Reaction
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)

http://identifiers.org/biomodels.db/MODEL1310110009#_3f624cd8_3e98_46bc_9bd4_0688a57867f8
is: B7Z6S1
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: GBA
constant: false
is encoded by: hsa:2629
type: Species
initial concentration: NaN
has only substance units: false

metaM 4abutn e
has only substance units: false
is: SBO:0000247
name: 4-ammoniobutanal
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:58264
type: Species
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: HMDB01080
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_be049ac2_f9a4_4806_9082_435eb8cf9ab8
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:1349
initial amount: NaN
name: COX7B
boundary condition: true
has only substance units: false
is: P24311

metaR GLCNACASE4ly
is version of: http://identifiers.org/ec-code/3.2.1.50
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
modifier: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000000
name: alpha-N-acetylglucosaminidase, lysosomal
reversible: false
fast: false
type: Reaction

metaR r0653
kinetic law: MODEL1310110009#
reversible: false
type: Reaction
product: MODEL1310110009#
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110009#

metaR MMSAD1m
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
type: Reaction
name: methylmalonate-semialdehyde dehydrogenase
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.27
modifier: MODEL1310110009#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_f1b99e2a_a367_494f_9178_d664a32ec9af
is encoded by: hsa:2592
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
name: GALT
initial concentration: NaN
is: E7ET32

http://identifiers.org/biomodels.db/MODEL1310110009#_de19bce9_d5ba_496d_a8e2_182edcaeac10
constant: false
has only substance units: false
boundary condition: true
is: O94788
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8854
is: SBO:0000252
name: ALDH1A2

metaM so4 c
initial amount: NaN
constant: false
name: sulfate
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
boundary condition: false
is: HMDB01448
is: CHEBI:16189
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species

metaM 5aizc c
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
boundary condition: false
is: CHEBI:58564
initial amount: NaN
is: HMDB06273
type: Species
is: SBO:0000247
is: C04751
constant: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_69bb31ee_7f74_40c1_80f5_75be0b582ae6
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:3101
is: P52790
constant: false
is: SBO:0000252
boundary condition: true
name: HK3

metaR r2314
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110009#
is described by: ECO:0000000

metaM anth e
is: HMDB01123
is: CHEBI:16567
has only substance units: false
boundary condition: false
name: anthranilate
type: Species
is: SBO:0000247
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
initial concentration: 1.0
initial amount: NaN
constant: false

metaM 4abutn c
is: CHEBI:58264
boundary condition: false
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
constant: false
type: Species
is: HMDB01080
has only substance units: false
initial amount: NaN
is: C00555
initial concentration: 1.0
name: 4-Aminobutanal
is: SBO:0000247

metaR NACHEX9ly
reversible: false
fast: false
product: MODEL1310110009#
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_dd9ebec6_0681_4634_9472_9d4e4f4c2539
initial concentration: NaN
type: Species
constant: false
has only substance units: false
name: _AI697028_1_e
boundary condition: true
is encoded by: hsa:AI697028
is: SBO:0000252
initial amount: NaN

metaR SPC HSt
name: sphingosylphosphorylcholine transport (diffusion)
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000185
reversible: true
reactant: MODEL1310110009#

metaM 3ohdcoa x
name: 3-oxopalmitoyl-CoA(4-)
is: HMDB06402
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57349
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_1bae7f2c_a814_4bf2_8ce5_d49a0ebe14d1
is encoded by: hsa:50484
is: SBO:0000252
is: Q7LG56
initial concentration: NaN
has only substance units: false
name: RRM2B
initial amount: NaN
boundary condition: true
constant: false
type: Species

metaM C04849 e
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
has only substance units: false
is: CHEBI:57449
constant: false
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_f2fd60d4_e995_43f1_bbc3_74024b882bb3
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110009#_563331e6_22ba_40bd_98b3_050899431231
constant: false
initial concentration: NaN
initial amount: NaN
is: Q15147
type: Species
boundary condition: true
name: PLCB4
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5332

metaR r1782
is: SBO:0000185
fast: false
product: MODEL1310110009#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
modifier: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#

metaM cdp e
constant: false
is: SBO:0000247
name: CDP(3-)
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: HMDB01546
is: CHEBI:58069

http://identifiers.org/biomodels.db/MODEL1310110009#_73aab998_0830_46c3_b0f3_4f0295f696a5
initial amount: NaN
is: Q16348
is: SBO:0000252
name: SLC15A2
has only substance units: false
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:6565

metaR r2315
product: MODEL1310110009#
is: SBO:0000185
reactant: MODEL1310110009#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
fast: false

metaR r0509
is described by: ECO:0000000
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
product: MODEL1310110009#
type: Reaction
reversible: false
reactant: MODEL1310110009#
is: SBO:0000176
kinetic law: MODEL1310110009#
fast: false

metaM trdrd c
is: SBO:0000247
is: C00342
name: Reduced thioredoxin
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
constant: false
is: CHEBI:15967
has only substance units: false

metaM c6dc c
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00705
has only substance units: false
name: adipoyl carnitine
boundary condition: false
notes: FORMULA: C13H22NO6 CHARGE: -1

metaR r0502
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
modifier: MODEL1310110009#
is described by: ECO:0000000
kinetic law: MODEL1310110009#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.113
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reactant: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#

metaR r0655
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
reversible: true
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
is version of: http://identifiers.org/ec-code/1.5.1.2
type: Reaction
fast: false
modifier: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_28e82a10_2abf_43a7_a44f_b7f8aac7a6a7
constant: false
name: GUCY2D
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3000
type: Species
initial concentration: NaN
is: Q02846

metaM 34hpp c
is: SBO:0000247
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
type: Species
initial amount: NaN
is: HMDB00707
name: 3-(4-hydroxyphenyl)pyruvate
constant: false
is: CHEBI:36242
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR r2316
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reactant: MODEL1310110009#
product: MODEL1310110009#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_a3891168_dfc5_4289_86e9_29cec24384f5
initial concentration: NaN
is encoded by: hsa:54965
constant: false
has only substance units: false
name: PIGX:PIGM
has part: Q8TBF5
is encoded by: hsa:93183
has part: Q9H3S5
boundary condition: true
is: SBO:0000297
type: Species
initial amount: NaN

metaM gd3 hs g
is: CHEBI:28424
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
name: GD3

http://identifiers.org/biomodels.db/MODEL1310110009#_9b5aeb2f_bcd0_419a_841f_d6838d3f9267
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI653169
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: _AI653169_1_c

metaR NS26T2g
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.99.3
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reversible: false
notes: GENE_ASSOCIATION: (55808.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.3 Confidence Level: 0 AUTHORS: PMID:10536037 NOTES:NCD
is: SBO:0000176
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
type: Reaction
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_13dd7f8c_2e47_43d7_b207_6c4eea8657c8
is: Q13370
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:5140
boundary condition: true
name: PDE3B

metaR FUMTSULtm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110009#
is described by: ECO:0000269
name: Fumarate:thiosulfate antiport, mitochondrial
reversible: true
modifier: MODEL1310110009#
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110009#
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_67835dc3_5600_4ce4_a842_f7027a89a189
has only substance units: false
name: PFKL
is: Q7L2M7
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:5211
is: SBO:0000252
initial amount: NaN

metaR DOLPMT2 Uer
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
reactant: MODEL1310110009#
is: SBO:0000176
kinetic law: MODEL1310110009#
product: MODEL1310110009#
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110009#_257af6d9_6277_4895_a427_ddea8deb973b
name: ACSL1
initial amount: NaN
is encoded by: hsa:2180
is: P33121
boundary condition: true
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_64b78608_5d4c_4f9c_b012_4bcf142a0f73
initial concentration: NaN
is: SBO:0000252
name: HADHB
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: P55084
is encoded by: hsa:3032
boundary condition: true

metaR r2317
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110009#
product: MODEL1310110009#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110009#
fast: false
is described by: ECO:0000000
type: Reaction

metaM paps g
has only substance units: false
constant: false
is: CHEBI:58339
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB01134
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053

metaR C14STRr
kinetic law: MODEL1310110009#
type: Reaction
reversible: false
reactant: MODEL1310110009#
name: C-14 sterol reductase
fast: false
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.3.1.70
is: SBO:0000176
is described by: ECO:0000134

metaM idour l
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
has only substance units: false
is: HMDB02704
constant: false
is: SBO:0000247
type: Species
is: CHEBI:21338
name: L-iduronate

metaM dolp L c
boundary condition: false
type: Species
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:57683
constant: false
name: dolichyl phosphate(2-)

metaM retinal cis 9 c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
name: all-trans-retinal
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
is: HMDB01358
is: CHEBI:17898
constant: false

metaM atp x
has only substance units: false
constant: false
type: Species
is: CHEBI:57299
initial concentration: 1.0
name: ATP(4-)
initial amount: NaN
is: HMDB00538
is: SBO:0000247
is: C00002
boundary condition: false

metaR r0504
is described by: ECO:0000000
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.3.10
reactant: MODEL1310110009#
is: SBO:0000176
reversible: true
fast: false
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
type: Reaction
modifier: MODEL1310110009#

metaM spmd c
boundary condition: false
constant: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: HMDB01257
is: CHEBI:57834
initial amount: NaN
name: Spermidine
is: SBO:0000247
is: C00315
has only substance units: false
type: Species
initial concentration: 1.0

metaM xolest2 hs e
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: cholesterol ester
type: Species
is: CHEBI:17002
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0

metaR r2318
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110009#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110009#
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction

metaR HCO3 CLt
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM
fast: false
product: MODEL1310110009#
modifier: MODEL1310110009#
reactant: MODEL1310110009#
name: bicarbonate transport (Cl-/HCO3- exchange)
type: Reaction
is: SBO:0000185

metaM ksi deg38 l
constant: false
type: Species
is: CHEBI:12936
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00143
name: keratan sulfate I, degradation product 38
notes: FORMULA: C54H91N3O41 CHARGE: 0

metaR CYSGLUexR
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
product: MODEL1310110009#
name: L-cysteine/L-glutamine reversible exchanger
reactant: MODEL1310110009#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110009#_beb843a7_69f0_41c3_bac2_b895271f4b95
initial amount: NaN
name: HADHB
is encoded by: hsa:3032
boundary condition: true
type: Species
is: P55084
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false

metaM 34hpp e
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
is: HMDB00707
name: 3-(4-hydroxyphenyl)pyruvate
constant: false
is: CHEBI:36242
is: SBO:0000247
initial concentration: 1.0

metaR r0809
is: SBO:0000185
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:
reactant: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
fast: false

metaM dag hs r
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
type: Species
constant: false
is: CHEBI:18035
has only substance units: false
is: SBO:0000247
boundary condition: false
name: diglyceride

metaR r1787
type: Reaction
name: Y+LAT2 Utilized transport
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000185
fast: false

metaM 3mob m
constant: false
has only substance units: false
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
initial amount: NaN
name: 3-methyl-2-oxobutanoate
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:11851

http://identifiers.org/biomodels.db/MODEL1310110009#_afcc8203_864e_48a2_ae2a_864daae25aea
boundary condition: true
name: SULT1A1
initial concentration: NaN
is encoded by: hsa:6817
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial amount: NaN

metaM dlnlcgcoa c
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: CHEBI:27979
is: SBO:0000247
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
name: dihomo-gamma-linolenyl coenzyme A
boundary condition: false
initial concentration: 1.0

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

metaM bilglcur r
constant: false
type: Species
is: CHEBI:57767
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
name: mono(glucosyluronic acid)bilirubin(2-)

http://identifiers.org/biomodels.db/MODEL1310110009#_42f78b5a_7e1f_4242_9a86_3f4cad093104
is encoded by: hsa:1666
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
name: DECR1
constant: false
is: Q16698
initial amount: NaN
is: SBO:0000252

metaR Uritm
name: uridine facilated transport in mitochondria
is: SBO:0000185
reversible: true
modifier: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
product: MODEL1310110009#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT

metaM CE4795 x
has only substance units: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,18-21,28-30,34-36,40,51-52H,4-7,10,13,16-17,22-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,19-18-,21-20+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4795
initial concentration: 1.0
name: 2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA
boundary condition: false
type: Species
is: CHEBI:57923
is: SBO:0000247
initial amount: NaN
constant: false

metaR r2319
product: MODEL1310110009#
reversible: true
fast: false
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110009#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110009#_58597a78_79d1_4404_b64b_393a52978c15
is encoded by: hsa:2194
is: P49327
name: FASN
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false

metaR TRPt
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
type: Reaction
reversible: true
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000269
modifier: MODEL1310110009#
is: SBO:0000185
name: L-tryptophan transport
fast: false
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_9c2f6802_5014_4523_9c47_f430ee899ee3
boundary condition: true
initial amount: NaN
has only substance units: false
is: B4DUG1
name: SLC24A1
is: SBO:0000252
is encoded by: hsa:9187
initial concentration: NaN
type: Species
constant: false

metaR MM6B2g
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
kinetic law: MODEL1310110009#
is: SBO:0000176
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
reactant: MODEL1310110009#
fast: false
type: Reaction
reversible: false
product: MODEL1310110009#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.113

metaR NRPPHRtu
type: Reaction
modifier: MODEL1310110009#
is: SBO:0000185
reactant: MODEL1310110009#
product: MODEL1310110009#
kinetic law: MODEL1310110009#
name: Norepinephrine uniport
reversible: true
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110009#_a06287d0_3120_4380_8b97_7190ea6ee28b
initial concentration: NaN
type: Species
name: RPE
has only substance units: false
is: Q96AT9
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6120

http://identifiers.org/biomodels.db/MODEL1310110009#_692a2917_3f09_4fcb_afbf_444a59ec5b40
constant: false
initial amount: NaN
name: PLCB1
is encoded by: hsa:23236
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR r2109
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
modifier: MODEL1310110009#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110009#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185

metaM c101crn c
has only substance units: false
notes: FORMULA: C17H31NO4 CHARGE: 0
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: decenoyl carnitine
is: HMDB13205
is: SBO:0000247
constant: false
type: Species

metaR r1459
type: Reaction
product: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
is: SBO:0000185
kinetic law: MODEL1310110009#
fast: false
reversible: true
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110009#_75414d73_33cb_4413_9701_aff3f31b6841
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:23556
initial amount: NaN
boundary condition: true
has only substance units: false
is: O95427
is: SBO:0000252
name: PIGN

http://identifiers.org/biomodels.db/MODEL1310110009#_4b80cea2_af81_404f_839b_bbc4d7885fbe
initial amount: NaN
is encoded by: hsa:65010
constant: false
initial concentration: NaN
is: Q9NQU1
name: SLC26A6
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_3ec02c14_b865_44f0_994e_d82ca6f4aede
boundary condition: true
is: SBO:0000252
constant: false
is: P51687
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: SUOX
is encoded by: hsa:6821

metaR CYSTA
reactant: MODEL1310110009#
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
name: cysteine transaminase
is described by: ECO:0000304
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
reversible: true
type: Reaction
product: MODEL1310110009#
fast: false

metaM sbcoa x
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
name: suberylcoa
type: Species
boundary condition: false
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM 34dhoxpeg e
notes: FORMULA: C8H10O4 CHARGE: 0 INCHI: InChI=1/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2 EHMN_ABBREVIATION: C05576
is: C05576
is: http://identifiers.org/pubchem.compound/7902
boundary condition: false
is: HMDB00318
constant: false
has only substance units: false
type: Species
name: 3,4-Dihydroxyphenylethyleneglycol
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_436195b6_ee57_45cb_8ce0_73595c0a2c99
is: O75715
has only substance units: false
is encoded by: hsa:2880
type: Species
boundary condition: true
name: GPX5
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_d52d21a3_d9a7_434d_b5bb_f5c24835cd2b
boundary condition: true
initial amount: NaN
is encoded by: hsa:5331
is: SBO:0000252
initial concentration: NaN
is: G5E960
name: PLCB3
has only substance units: false
type: Species
constant: false

metaR S6TASE13ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
reversible: true
product: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110009#_2be7f0fc_7f4f_4f5a_9a69_113eea62050c
is: Q13011
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1891
name: ECH1
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000252

metaR RE0688E
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.4.3.22
name: RE0688
reactant: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:

metaR SIAASE3ly
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110009#
is described by: ECO:0000000
modifier: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
name: sialidase, lysosomal
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_1d22bbf6_ff30_4439_a641_cc991bfa39bb
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
name: ALDOA
is encoded by: hsa:226
is: P04075

metaR r2108
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: true
product: MODEL1310110009#
reactant: MODEL1310110009#

metaR C120CPT1
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_18b4b93d_a1e8_4d9e_9ce1_40af6830e4af
is: Q9H0I9
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:84076
name: TKTL2
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaR FAOXC161802m
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110009#
reactant: MODEL1310110009#
reversible: false
product: MODEL1310110009#
is described by: ECO:0000269

metaR BTNDm
is version of: http://identifiers.org/ec-code/3.5.1.12
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
is described by: ECO:0000269
reversible: false
product: MODEL1310110009#
is: SBO:0000176
name: biotinidase (biotin), mitochondrial
modifier: MODEL1310110009#
fast: false
type: Reaction
kinetic law: MODEL1310110009#

metaR FAOXC163C164x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)x
type: Reaction

metaR CHOLtn
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
name: Choline transport, nuclear through pores
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
is: SBO:0000185

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_ee742774_9849_4aa5_b243_6f7741a5fe83
is: O00624
is encoded by: hsa:10246
constant: false
initial concentration: NaN
is: SBO:0000252
name: SLC17A2
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true

metaR THD1m
notes: GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES:TDV (2-6-2003)
reversible: true
product: MODEL1310110009#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110009#
name: NAD(P) transhydrogenase
kinetic law: MODEL1310110009#
fast: false
is version of: http://identifiers.org/ec-code/1.6.1.2
modifier: MODEL1310110009#
is described by: ECO:0000269

metaM strdnccoa x
initial concentration: 1.0
is: C16163
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB06519
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205473
name: stearidonyl coenzyme A
has only substance units: false

metaR FAOXC184m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_9af152ad_8d39_46d8_b003_f0fed045d7e0
is: P11182
name: DBT
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1629

metaR r2107
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
product: MODEL1310110009#
reactant: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
fast: false
is described by: ECO:0000000

metaM leuktrC4 r
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: HMDB01198
is: CHEBI:57973
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
name: leukotriene C4(2-)
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_839177e1_37cd_4a0b_b91f_4915eb9cd6af
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:8527
has only substance units: false
name: DGKD
type: Species

metaM c101crn e
notes: FORMULA: C17H31NO4 CHARGE: 0
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB13205
is: SBO:0000247
constant: false
initial concentration: 1.0
name: decenoyl carnitine
type: Species

metaR ACCOAtr
fast: false
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ changed name from ACCOArt to ACCOAtr for consistency - NCD
type: Reaction
is: SBO:0000185
reactant: MODEL1310110009#
reversible: true
name: acetyl-coa transport
kinetic law: MODEL1310110009#
is described by: ECO:0000000
modifier: MODEL1310110009#
product: MODEL1310110009#

metaM 4abutn m
is: HMDB01080
name: 4-ammoniobutanal
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:58264

http://identifiers.org/biomodels.db/MODEL1310110009#_ef687a07_34ec_4ca2_b9b1_7fb3591b074f
is encoded by: hsa:30
has only substance units: false
is: Q96CA6
type: Species
constant: false
boundary condition: true
name: ACAA1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR NACHEX17ly
product: MODEL1310110009#
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
fast: false
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction

metaM CE5132 c
initial concentration: 1.0
is: CHEBI:57923
constant: false
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)

metaR r2106
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reversible: true
product: MODEL1310110009#

metaM dtmp m
initial concentration: 1.0
name: dTMP
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: CHEBI:26999
boundary condition: false
is: HMDB01227
is: C00364
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false

metaM dcacoa x
boundary condition: false
is: CHEBI:61430
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C05274
constant: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
type: Species
name: Decanoyl-CoA (n-C10:0CoA)
is: HMDB06404
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_6ae7f42c_d73b_40d7_b326_3d2cdff8bec4
name: LTC4S
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4056
constant: false
initial concentration: NaN

metaR GLXtm
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
name: glyoxylate transport, mitochondrial
is: SBO:0000185
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
product: MODEL1310110009#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110009#_8153fa03_cebd_493c_9a73_8c73000ed636
name: ACOX3
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8310
is: O15254
boundary condition: true
constant: false
has only substance units: false
type: Species
is: SBO:0000252

metaM mescon m
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
is: HMDB00749
is: CHEBI:36986
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: Mesaconate
boundary condition: false
constant: false
type: Species
is: SBO:0000247

metaR PI345P3P
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.67
kinetic law: MODEL1310110009#
reversible: false
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110009#
modifier: MODEL1310110009#

metaR G14T11g
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
reactant: MODEL1310110009#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

http://identifiers.org/biomodels.db/MODEL1310110009#_194a159f_9981_44d6_9014_a02889b6dd17
constant: false
boundary condition: true
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:518
type: Species
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110009#_9a05414a_b249_4e9b_ac0b_8eec3ac3191a
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5283
constant: false
name: PIGH
is: Q14442
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_f82ee910_ad26_4426_b698_0e98c1c0ba4e
is: SBO:0000252
name: QPRT
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:23475
type: Species
is: Q15274
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_9242fc54_0960_4c8e_869c_21231db04b6f
is: SBO:0000252
is encoded by: hsa:226
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: ALDOA
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_83bd5e27_2c8f_435f_be13_74cdc50a4c1c
is: B3KQ63
constant: false
name: HPD
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3242
type: Species
is: SBO:0000252
has only substance units: false

metaM CE1944 c
initial concentration: 1.0
is: CHEBI:36781
initial amount: NaN
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
boundary condition: false
constant: false
has only substance units: false
name: 1-pyrrolinium
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_b568865e_92ee_4a63_8194_a171d4ddcd04
initial amount: NaN
is: Q92781
is encoded by: hsa:5959
initial concentration: NaN
is: SBO:0000252
name: RDH5
has only substance units: false
constant: false
boundary condition: true
type: Species

metaM prgstrn c
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:17026
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410
initial concentration: 1.0
is: HMDB01830
name: progesterone
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_6a4b152f_c1ac_43ff_8fd7_a629b43cd399
constant: false
initial amount: NaN
is encoded by: hsa:54344
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:8818
has part: Q9P2X0
boundary condition: true
name: DPM3:DPM1:DPM2

metaR 34DHPHEt
reversible: true
modifier: MODEL1310110009#
fast: false
product: MODEL1310110009#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110009#
name: 3,4-Dihydroxy-L-phenylalanine transport

metaR DOPABMO
reversible: false
type: Reaction
is described by: ECO:0000269
fast: false
is: SBO:0000176
product: MODEL1310110009#
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (26002.1) or (1621.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.17.1 Confidence Level: 4 AUTHORS: NOTES:SAB
name: dopamine beta-monooxygenase
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.14.17.1

metaR EX 9 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 9-cis-retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_e0d25589_a495_4206_a9cd_93680b6ae1de
name: ACADSB
initial concentration: NaN
type: Species
is encoded by: hsa:36
is: P45954
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM m5masnB2 g
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C52H87N2O40X CHARGE: 0
boundary condition: false
constant: false
type: Species
is: CHEBI:58401
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: HMDB06814
has only substance units: false

metaR ASCBt4
name: L-ascorbate transport via proton symport
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110009#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
type: Reaction
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_0c3d94ff_3307_455d_87f5_96cf063b3112
initial concentration: NaN
is: P28331
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:4719
is: SBO:0000252
type: Species
name: NDUFS1

metaR KCC2t
modifier: MODEL1310110009#
name: K+-Cl- cotransporter (NH4+)
kinetic law: MODEL1310110009#
is described by: ECO:0000269
reversible: true
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD

metaR GTHDH
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
type: Reaction
kinetic law: MODEL1310110009#
fast: false
is described by: ECO:0000134
reversible: false
product: MODEL1310110009#
name: Glutathione dehydrogenase (dehydroascorbate reductase)
reactant: MODEL1310110009#
is: SBO:0000176

metaR FACOAL206
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110009#
fast: false
name: fatty-acid--CoA ligase
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#

metaR RDH1
modifier: MODEL1310110009#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.315
name: retinol dehydrogenase (all-trans)
is described by: ECO:0000269
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
reversible: true
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT

metaR GCC2cm
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.8.1.4
reversible: true
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
reactant: MODEL1310110009#
product: MODEL1310110009#
name: glycine-cleavage complex (lipoamide), mitochondrial
is version of: http://identifiers.org/ec-code/2.1.2.10
fast: false
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.4.4.2
is: SBO:0000176
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110009#_24407241_da23_4420_b5ab_082e83955708
initial concentration: NaN
boundary condition: true
type: Species
constant: false
name: _AA664770_1_m
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AA664770

metaR r1768
kinetic law: MODEL1310110009#
is: SBO:0000185
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_a558aa8d_6555_4b9c_bc43_7618115be573
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:27068
name: PPA2

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaM 34dhoxpeg c
notes: FORMULA: C8H10O4 CHARGE: 0 INCHI: InChI=1/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2 EHMN_ABBREVIATION: C05576
is: C05576
has only substance units: false
is: http://identifiers.org/pubchem.compound/7902
is: HMDB00318
name: 3,4-Dihydroxyphenylethyleneglycol
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN

metaR DPCOAK
is version of: http://identifiers.org/ec-code/2.7.7.3
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110009#
fast: false
product: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110009#
is: SBO:0000176
name: dephospho-CoA kinase

metaM hdd2coa c
constant: false
has only substance units: false
is: HMDB03945
boundary condition: false
is: SBO:0000247
is: C05272
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
type: Species
initial amount: NaN
is: CHEBI:61526
name: trans-Hexadec-2-enoyl-CoA
initial concentration: 1.0

metaM 12ppd R c
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
name: (R)-propane-1,2-diol
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
is: CHEBI:28972
has only substance units: false
boundary condition: false
is: HMDB01881
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_ba0b6a30_18c5_44e3_a406_9ac1823558fc
name: PRDX2
is encoded by: hsa:7001
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
type: Species

metaM 10fthf c
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:57454
name: 10-Formyltetrahydrofolate
boundary condition: false
is: C00234
initial amount: NaN
is: HMDB00972
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_febf4091_d525_4fb2_9ff8_2a8b5618626e
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is: Q9NRR6
is encoded by: hsa:56623
name: INPP5E
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_d260320a_6653_466d_befb_7f7b06f4cafb
is: O00142
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
name: TK2
is encoded by: hsa:7084
is: SBO:0000252

metaR ILEtec
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
name: L-isoleucine transport via diffusion (extracellular to cytosol)
type: Reaction
kinetic law: MODEL1310110009#
product: MODEL1310110009#
fast: false
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000185

metaR r0672
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
product: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.65
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
type: Reaction
reversible: true
is: SBO:0000176
is described by: ECO:0000000

metaM prgstrn e
has only substance units: false
is: SBO:0000247
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410
constant: false
initial amount: NaN
is: CHEBI:17026
type: Species
boundary condition: false
is: HMDB01830
initial concentration: 1.0
name: progesterone

http://identifiers.org/biomodels.db/MODEL1310110009#_203acc8f_2f69_4d34_86da_804dee252278
initial amount: NaN
is: P27144
is: SBO:0000252
constant: false
type: Species
name: AK4
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:205

http://identifiers.org/biomodels.db/MODEL1310110009#_5235e6d4_555b_479f_85b8_db6216f9de1e
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q9NPH0
initial amount: NaN
name: ACP6
type: Species
is encoded by: hsa:51205
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_0c791935_8324_42ae_9080_5e23b5672516
is: SBO:0000252
constant: false
is encoded by: hsa:262
has only substance units: false
is: P17707
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
name: AMD1

http://identifiers.org/biomodels.db/MODEL1310110009#_7b73f07d_93c8_465a_a26a_4d72d8cfecc7
initial amount: NaN
is encoded by: hsa:1109
name: AKR1C4
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false
is: P17516
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_2410efac_c825_476b_b1b1_1ee7cf32d8c2
initial amount: NaN
type: Species
constant: false
name: EHHADH
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1962
is: Q9NY65
is: SBO:0000252

metaM damp c
initial concentration: 1.0
is: CHEBI:58245
is: HMDB00905
boundary condition: false
name: dAMP(2-)
constant: false
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaM hs l
has only substance units: false
initial amount: NaN
is: CHEBI:28815
name: heparan sulfate, free chain
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
constant: false
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR CSAPASEly
is: SBO:0000176
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110009#_4eefe181_3f51_47da_8e48_0d86f7526aed
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR THCHOLSTOICtm
reactant: MODEL1310110009#
product: MODEL1310110009#
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaM ptdcacrn m
is: CHEBI:18303
boundary condition: false
is: SBO:0000247
constant: false
name: pendtadenoyl carnitine
initial concentration: 1.0
type: Species
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_03800649_7eb1_4aab_ae4a_b72e034e9260
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:3417
is: O75874
name: IDH1
is: SBO:0000252

metaR FACOAL204
modifier: MODEL1310110009#
fast: false
is described by: ECO:0000269
name: fatty-acid--CoA ligase
type: Reaction
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
reversible: true
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_053fc8e1_f157_436a_967a_5e1800192880
initial concentration: NaN
name: HMGCS1
is: Q01581
boundary condition: true
is encoded by: hsa:3157
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
has only substance units: false

metaR FPGS5m
name: folylpolyglutamate synthetase (DHF), mitochondrial
reactant: MODEL1310110009#
reversible: false
is: SBO:0000176
product: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/6.3.2.17
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_e08879f4_59f3_4b33_a920_9ac195a02143
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4722
name: NDUFS3
initial amount: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
is: O75489

http://identifiers.org/biomodels.db/MODEL1310110009#_bf5ec25b_6870_413e_9bdb_1465fa16fc8f
boundary condition: true
has only substance units: false
name: ACLY
type: Species
is encoded by: hsa:47
is: P53396
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN

metaR r0671
is: SBO:0000176
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.22
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110009#
product: MODEL1310110009#
name: (R)-4-Phosphopantothenate:L-cysteine ligase EC:6.3.2.5
reactant: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (2717.1) or (6173.1) SUBSYSTEM: CoA synthesis EC Number: 6.3.2.5 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:12906824,PMID:15893380 NOTES:

metaR EX retinol 9 cis LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-cis-retinol exchange
type: Reaction

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaR C81CPT1
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of ocetenoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_fcb1c661_e2f4_4a60_9ced_24bab3691093
has only substance units: false
is encoded by: hsa:222
is: SBO:0000252
boundary condition: true
name: ALDH3B2
initial amount: NaN
initial concentration: NaN
constant: false
is: P48448
type: Species

metaR AMETt2m
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
product: MODEL1310110009#
reactant: MODEL1310110009#
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
is described by: ECO:0000269
reversible: true
type: Reaction
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110009#_d0758b13_d315_4072_a25e_faac049e2005
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
name: ACAA2
is: SBO:0000252
is: P42765
initial concentration: NaN
is encoded by: hsa:10449
type: Species

metaR RDH4
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:9115228 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.315
kinetic law: MODEL1310110009#
is: SBO:0000176
modifier: MODEL1310110009#
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110009#
reactant: MODEL1310110009#
reversible: true
name: retinol dehydrogenase (13-cis,NADH)

metaR r0393
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
reversible: false
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.1.74
reactant: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_d6a2df66_7ea1_45fd_888a_e1be61fa57cb
initial amount: NaN
is: SBO:0000252
is: P14618
has only substance units: false
name: PKM2
is encoded by: hsa:5315
initial concentration: NaN
constant: false
boundary condition: true
type: Species

metaR S6T13g
kinetic law: MODEL1310110009#
reversible: false
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110009#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110009#

metaM acnamp c
name: N-Acetylneuraminate 9-phosphate
type: Species
initial amount: NaN
boundary condition: false
is: HMDB06268
notes: FORMULA: C11H17NO12P CHARGE: -3 INCHI: InChI=1S/C11H20NO12P/c1-4(13)12-7-5(14)2-11(19,10(17)18)24-9(7)8(16)6(15)3-23-25(20,21)22/h5-9,14-16,19H,2-3H2,1H3,(H,12,13)(H,17,18)(H2,20,21,22)/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01734 EHMN_ABBREVIATION: C06241
has only substance units: false
is: CHEBI:27438
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR r2101
product: MODEL1310110009#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110009#
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM ddece1crn c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C19H35NO4 CHARGE: 0
initial amount: NaN
type: Species
constant: false
is: HMDB03712
name: dodecenoyl carnitine
has only substance units: false

metaM nm4masn g
is: C05882
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C54H90N3O40X CHARGE: 0
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN

metaR r1451
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
is described by: ECO:0000000
product: MODEL1310110009#
is: SBO:0000176
kinetic law: MODEL1310110009#
reversible: false
name: EC:1.3.3.6
reactant: MODEL1310110009#
fast: false

metaR APOCF
type: Reaction
name: Apocarboxylase formation
product: MODEL1310110009#
is described by: ECO:0000000
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
reactant: MODEL1310110009#

metaR C5DCe
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of glutaryl carnitine into the extra cellular fluid
type: Reaction

metaR EX 3ivcrn
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-isovaleryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_82bc27d5_e2b6_470a_af4e_bd4d989b31e5
is: SBO:0000252
is encoded by: hsa:9856
initial amount: NaN
boundary condition: true
constant: false
type: Species
name: DYLX2
has only substance units: false
initial concentration: NaN
is: F5H123

metaM 6dhf m
initial concentration: 1.0
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
is: HMDB06563
initial amount: NaN
name: hexaglutamyl folate (DHF)
constant: false
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_5ce5f5d7_4238_4144_ab12_2b67d54e9794
name: PGK1
constant: false
is: P00558
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:5230
is: SBO:0000252
initial concentration: NaN

metaR PTDCACRNt
is described by: ECO:0000000
reactant: MODEL1310110009#
name: pentadecanoate transport into the mitochondria
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
product: MODEL1310110009#
fast: false
type: Reaction
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ

metaM fprica c
constant: false
initial concentration: 1.0
has only substance units: false
is: C04734
is: SBO:0000247
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
is: HMDB01439
is: CHEBI:58467

metaR M16NTg
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.143
is: SBO:0000176
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
modifier: MODEL1310110009#
fast: false
reversible: false
product: MODEL1310110009#
is described by: ECO:0000000

metaR r0392
kinetic law: MODEL1310110009#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
reactant: MODEL1310110009#
product: MODEL1310110009#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_854ca02a_d2d2_4955_9238_1e217cf3c836
boundary condition: true
constant: false
initial amount: NaN
name: ACOX1
is: SBO:0000252
has only substance units: false
is: B4DK61
type: Species
initial concentration: NaN
is encoded by: hsa:51

metaR RE1796M
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.145
is: SBO:0000176
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
fast: false
type: Reaction
product: MODEL1310110009#
reversible: true
name: RE1796

http://identifiers.org/biomodels.db/MODEL1310110009#_91a3f2fe_7143_4af6_bd30_2d9f77879d1b
is: D9HTE9
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
name: SLC25A1
has only substance units: false
type: Species
is encoded by: hsa:6576
is: SBO:0000252

metaM pro L c
is: CHEBI:17203
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
boundary condition: false
has only substance units: false
name: L-proline
is: SBO:0000247
initial concentration: 1.0
is: HMDB00162
initial amount: NaN
type: Species

metaR DITPtn
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110009#
name: dITP nuclear transport
reversible: true
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110009#
fast: false

metaM idp c
constant: false
initial amount: NaN
boundary condition: false
is: HMDB03335
initial concentration: 1.0
name: IDP(3-)
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:58280

metaR r2100
product: MODEL1310110009#
modifier: MODEL1310110009#
fast: false
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110009#
is described by: ECO:0000000

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

metaR RE0344C
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: true
type: Reaction
reactant: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
name: RE0344
is: SBO:0000176
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.1.2.2

metaR RDH2
is version of: http://identifiers.org/ec-code/1.1.1.315
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
name: retinol dehydrogenase (9-cis,NADH)
is: SBO:0000176
product: MODEL1310110009#
fast: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110009#
reversible: true

metaM 6dhf l
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
is: HMDB06563
initial amount: NaN
has only substance units: false
boundary condition: false
name: hexaglutamyl folate (DHF)
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR ADSS
reactant: MODEL1310110009#
reversible: false
is version of: http://identifiers.org/ec-code/6.3.4.4
type: Reaction
is described by: ECO:0000134
product: MODEL1310110009#
fast: false
is: SBO:0000176
modifier: MODEL1310110009#
name: adenylosuccinate synthase
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277

metaR ENGASE3ly
type: Reaction
name: endo-beta-N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110009#
is described by: ECO:0000000
reversible: false
is: SBO:0000176

metaM ddece1crn e
is: HMDB02250
initial concentration: 1.0
notes: FORMULA: C19H35NO4 CHARGE: 0
has only substance units: false
is: SBO:0000247
type: Species
name: dodecenoyl carnitine
boundary condition: false
constant: false
initial amount: NaN

metaR FAOXC122m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaM prostgi2 e
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57403
name: prostaglandin I2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
type: Species
is: HMDB01335
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_082242ea_5e93_4367_9376_b6216a4d4983
is: Q86V21
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:65985
boundary condition: true
initial concentration: NaN
name: AACS

metaM docohexcoa x
constant: false
has only substance units: false
name: 2,4,7,10,13,16-docosahexenoylcoa
type: Species
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_71ba189f_537c_4418_a929_bc9b085ada72
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3795
is: SBO:0000252
name: KHK
type: Species
is: P50053
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_5fc0c558_b014_4c9d_8f16_d099b0b6dd64
initial concentration: NaN
name: ECI1
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: P42126
is encoded by: hsa:1632
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_31f01b8b_8e5c_4fd1_b8fa_60635350b332
is: SBO:0000252
is encoded by: hsa:517
has only substance units: false
constant: false
name: ATP5G2
boundary condition: true
initial amount: NaN
is: Q06055
initial concentration: NaN
type: Species

metaM dtmp e
constant: false
is: HMDB01227
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
name: dTMP(2-)
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial amount: NaN
type: Species
is: CHEBI:26999

metaR RDH3
name: retinol dehydrogenase (11-cis,NADH)
is: SBO:0000176
product: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
modifier: MODEL1310110009#
reversible: true
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.315
kinetic law: MODEL1310110009#
fast: false
is described by: ECO:0000269

metaM methf m
initial amount: NaN
has only substance units: false
is: CHEBI:57455
is: HMDB01354
constant: false
name: (6R)-5,10-methenyltetrahydrofolate
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_8b0a1b0e_544f_4ea3_80fe_ffef343d2a33
initial amount: NaN
name: NDUFA3
boundary condition: true
is: O95167
constant: false
is encoded by: hsa:4696
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false

metaM dolp L r
boundary condition: false
constant: false
name: dolichyl phosphate(2-)
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: CHEBI:57683
has only substance units: false

metaR SPMS
product: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.5.1.16
type: Reaction
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (6723.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.16 Confidence Level: 4 AUTHORS: PMID:2069720,PMID:8343131 NOTES:
reversible: false
is: SBO:0000176
name: spermidine synthase
fast: false

metaM idp e
is: HMDB03335
is: SBO:0000247
name: IDP(3-)
is: CHEBI:58280
type: Species
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false

metaM mi34p c
is: HMDB06235
has only substance units: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C04063
initial amount: NaN
boundary condition: false
type: Species
name: 1D-myo-Inositol 3,4-bisphosphate
is: CHEBI:28858
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR r0394
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reactant: MODEL1310110009#
fast: false
product: MODEL1310110009#

metaR PETOHMr hs
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/2.1.1.17
reversible: false
modifier: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-Prot] NJ
reactant: MODEL1310110009#
fast: false
name: phosphatidylethanolamine N-methyltransferase
is: SBO:0000176

metaR C140CPT1
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of myristoylcarnitine
type: Reaction

metaM acgal1p c
is: CHEBI:55404
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
constant: false
boundary condition: false
initial concentration: 1.0
name: N-Acetyl-D-galactosamine 1-phosphate
is: HMDB06480
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_5ba102bc_0aa5_401d_8f08_32435fe84dbb
initial amount: NaN
type: Species
name: ADCY6
is: SBO:0000252
constant: false
is encoded by: hsa:112
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_d7b9d056_864d_4dd3_a9f0_012e0aba2794
is: SBO:0000252
constant: false
name: GPX2
initial amount: NaN
is encoded by: hsa:2877
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is: P18283

http://identifiers.org/biomodels.db/MODEL1310110009#_1d9d65ca_6faf_4aa1_a730_1f1650d79b2c
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
name: ACOX1
has only substance units: false
boundary condition: true
is encoded by: hsa:51
constant: false
is: B4DK61

metaM 10fthf m
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: HMDB00972
type: Species
is: CHEBI:57454
name: 10-formyltetrahydrofolate(2-)
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false

metaM xylt e
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
initial amount: NaN
name: xylitol
initial concentration: 1.0
is: CHEBI:17151
constant: false
is: HMDB02917
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species

metaR r2105
reversible: true
type: Reaction
modifier: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110009#
fast: false
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_3f07ada9_c362_46d3_998d_67397e6bf23f
constant: false
name: SLC25A4
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is: P12235
is encoded by: hsa:291

metaM Sfglutth c
is: CHEBI:57688
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
name: S-formylglutathionate(1-)
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB01550
initial concentration: 1.0
type: Species

metaR ACACT10m
product: MODEL1310110009#
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
name: acetyl-CoA C-acetyltransferase, mitochondrial
is version of: http://identifiers.org/ec-code/2.3.1.9
is described by: ECO:0000134
kinetic law: MODEL1310110009#
type: Reaction
fast: false
reactant: MODEL1310110009#
reversible: true
is: SBO:0000176

metaR RE1533M
name: RE1533
is: SBO:0000176
kinetic law: MODEL1310110009#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110009#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction

metaM hdd2coa m
constant: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
boundary condition: false
is: HMDB03945
name: trans-Hexadec-2-enoyl-CoA
initial concentration: 1.0
is: C05272
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:61526
type: Species

metaM ksi deg9 l
is: HMDB00143
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:12936
initial amount: NaN
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
name: keratan sulfate I, degradation product 9
boundary condition: false
has only substance units: false
constant: false
type: Species

metaR r2104
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110009#

metaR UMPK3n
reversible: true
modifier: MODEL1310110009#
fast: false
name: UMP kinase (UTP),nuclear
type: Reaction
reactant: MODEL1310110009#
is: SBO:0000176
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaM 3uib c
is: SBO:0000247
name: 3-Ureidoisobutyrate
is: CHEBI:1670
initial amount: NaN
boundary condition: false
is: HMDB02031
notes: FORMULA: C5H9N2O3 CHARGE: -1 INCHI: InChI=1S/C5H10N2O3/c1-3(4(8)9)2-7-5(6)10/h3H,2H2,1H3,(H,8,9)(H3,6,7,10) HEPATONET_1.0_ABBREVIATION: HC01371 EHMN_ABBREVIATION: C05100
initial concentration: 1.0
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_371d0c00_4456_47a1_9f9f_b4fc802f38b5
type: Species
has only substance units: false
is: Q96SL4
initial concentration: NaN
constant: false
is encoded by: hsa:2882
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: GPX7

metaR FATP9t
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
name: fatty acid electroneutral transport
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110009#
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/6.2.1.7
is: SBO:0000185
product: MODEL1310110009#
reversible: true
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ

metaR GLCNACASE3ly
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reactant: MODEL1310110009#
reversible: false
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.50
name: alpha-N-acetylglucosaminidase, lysosomal

metaM ptdcacrn c
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
initial amount: NaN
is: SBO:0000247
name: pendtadenoyl carnitine
is: CHEBI:18303
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
type: Species

metaR IMPC
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
is: SBO:0000176
name: IMP cyclohydrolase
product: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.1.2.3
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
is described by: ECO:0000269
fast: false

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR r2103
is: SBO:0000185
product: MODEL1310110009#
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110009#_096d6d68_6cf4_4f9c_b9b4_a1f779c61557
name: ALDH2
is: P05091
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:217
type: Species

metaR DPMVDc
fast: false
product: MODEL1310110009#
name: diphosphomevalonate decarboxylase, cytosol
is described by: ECO:0000134
is: SBO:0000176
reversible: false
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added t product for elemental balancing.
reactant: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/4.1.1.33

http://identifiers.org/biomodels.db/MODEL1310110009#_b2a97480_1ca0_43b4_8e9e_f637f0bf7489
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q7Z7B1
is encoded by: hsa:284098
name: PIGW

metaR r0399
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.2.4.2
fast: false
product: MODEL1310110009#
reversible: true
type: Reaction
is described by: ECO:0000000
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
is: SBO:0000176

metaM galside hs l
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
type: Species
boundary condition: false
is: CHEBI:12947
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
name: D-galactosyl-N-acylsphingosine
has only substance units: false

metaR RE1796R
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.145
is: SBO:0000176
reactant: MODEL1310110009#
is described by: ECO:0000000
modifier: MODEL1310110009#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
kinetic law: MODEL1310110009#
reversible: true
name: RE1796

metaM xylt c
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB02917
name: xylitol
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:17151
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379

metaR AKGtp
reversible: true
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110009#
name: AKG transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
is: SBO:0000185

metaR ACCOAtn
reactant: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: acetyl-CoA transport, nuclear
is: SBO:0000185
reversible: true
product: MODEL1310110009#
is described by: ECO:0000000

metaR MACACI
modifier: MODEL1310110009#
is described by: ECO:0000269
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.5.1.18
is: SBO:0000176
reversible: false
name: maleylacetoacetate isomerase
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_f4fcefe6_90fe_45f9_ad56_79db7c1e95cc
has only substance units: false
initial amount: NaN
type: Species
is: Q15758
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6510
boundary condition: true
constant: false
name: SLC1A5

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

metaM c226crn c
name: cervonyl carnitine
has only substance units: false
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
initial concentration: 1.0
constant: false
is: HMDB06510
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/127055
type: Species

metaR SMPD4
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
reversible: false
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
fast: false
name: sphingomyelinase
reactant: MODEL1310110009#
is: SBO:0000176

metaM g1p c
is: SBO:0000247
is: C00103
is: CHEBI:58601
constant: false
initial concentration: 1.0
type: Species
name: D-Glucose 1-phosphate
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB01586
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103

metaR r1177
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
product: MODEL1310110009#
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000000
name: EC:3.1.1.13
reactant: MODEL1310110009#

metaM pro L e
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
type: Species
initial concentration: 1.0
is: HMDB00162
is: CHEBI:17203
name: L-proline
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR r2102
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#

metaR AG13T2g
type: Reaction
kinetic law: MODEL1310110009#
product: MODEL1310110009#
modifier: MODEL1310110009#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176

metaM CE4876 r
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
name: delta12-Prostaglandin J2
is: CHEBI:57923
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_dfdd8234_77ab_41e8_b243_55d1569d526a
is: P49915
boundary condition: true
name: GMPS
is: SBO:0000252
is encoded by: hsa:8833
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
constant: false

metaR r2443
reactant: MODEL1310110009#
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110009#
product: MODEL1310110009#
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110009#_83227a99_26e2_47fe_bae4_d63515108d7f
boundary condition: true
is: SBO:0000252
is encoded by: hsa:30
initial concentration: NaN
initial amount: NaN
is: Q96CA6
constant: false
has only substance units: false
type: Species
name: ACAA1

metaR G6PDA
notes: GENE_ASSOCIATION: (132789.1) or (10007.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.99.6 Confidence Level: 4 AUTHORS: PMID:9714720 NOTES:Previously EC 5.3.1.10
modifier: MODEL1310110009#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
name: glucosamine-6-phosphate deaminase
is version of: http://identifiers.org/ec-code/3.5.99.6
kinetic law: MODEL1310110009#
fast: false
reversible: false
reactant: MODEL1310110009#
product: MODEL1310110009#

metaR ETF
product: MODEL1310110009#
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110009#
reversible: false
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
name: electron transfer flavoprotein

http://identifiers.org/biomodels.db/MODEL1310110009#_5b412a0d_0914_4ae1_85a1_eab2c979a68c
is: SBO:0000252
boundary condition: true
type: Species
name: ENTPD4
is encoded by: hsa:9583
is: Q9Y227
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_bca9cc1a_2d98_4cf9_af89_85fd74e12208
is encoded by: hsa:6888
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
name: TALDO1
constant: false
is: P37837
is: SBO:0000252
initial concentration: NaN

metaR NDP8
product: MODEL1310110009#
reversible: false
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
name: nucleoside-diphosphatase (dUDP)
is version of: http://identifiers.org/ec-code/2.7.4.9

metaM HC00460 c
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
name: 2,5-dihydroxybenzoate
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:58044

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaR COAtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
reversible: true
fast: false
name: CoA transport in Golgi via diffusion
reactant: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
is: SBO:0000185
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_a9488fcb_01c6_43cb_9412_86726fa21a1b
initial concentration: NaN
boundary condition: true
constant: false
name: SLC7A8
type: Species
is: SBO:0000252
is encoded by: hsa:23428
initial amount: NaN
is: Q86U05
has only substance units: false

metaR r0512
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
reactant: MODEL1310110009#
reversible: true
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
fast: false
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.17.4.1

metaR r1883
name: Y+LAT2 Utilized transport
product: MODEL1310110009#
reversible: false
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110009#

metaM trdox m
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
name: Oxidized thioredoxin
is: CHEBI:18191

metaR URIK1
is version of: http://identifiers.org/ec-code/2.7.1.48
is: SBO:0000176
product: MODEL1310110009#
name: uridine kinase (ATP:Uridine)
reversible: false
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000269
type: Reaction
fast: false
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:

metaR NOt
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
type: Reaction
product: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000000
name: NO transport (diffusion)

http://identifiers.org/biomodels.db/MODEL1310110009#_6b5af18c_625a_4f0a_a23c_89d010da0c7f
constant: false
name: ECHS1
is encoded by: hsa:1892
is: SBO:0000252
is: P30084
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false

metaM hs deg25 l
has only substance units: false
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16126
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
notes: FORMULA: C23H37O21 CHARGE: -1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_f00ecf30_0979_4182_b8bc_2937284dc02d
is: SBO:0000252
has only substance units: false
is: P53602
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:4597
name: MVD

metaM leuleu c
boundary condition: false
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/94244
name: Leucylleucine
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C12H24N2O3 CHARGE: 0
type: Species
constant: false

metaM retn e
is: CHEBI:35291
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
name: all-trans-retinoate
type: Species
has only substance units: false
constant: false
is: HMDB01852

metaR CMPSASn
product: MODEL1310110009#
name: CMP sialic acid synthase, nuclear
is version of: http://identifiers.org/ec-code/2.7.7.43
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
is: SBO:0000176
reversible: false
is described by: ECO:0000304
modifier: MODEL1310110009#
fast: false
type: Reaction
reactant: MODEL1310110009#

metaR RE0926E
modifier: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
name: RE0926
fast: false
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.17
product: MODEL1310110009#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110009#_f7cfe6e1_d64e_4d18_a5cc_fb94ab0ed4fc
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:6723
is: P19623
name: SRM
has only substance units: false
is: SBO:0000252

metaM 2octpencoa m
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: 2,6,9,12,15-octadecapentenoylcoa
is: http://identifiers.org/pubchem.compound/5280355
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_f049b2e4_70a3_4bd8_8c72_34802f5dc951
name: MYO5B
is encoded by: hsa:4645
initial concentration: NaN
initial amount: NaN
constant: false
is: Q9H6Y6
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252

metaM HC01403 m
initial concentration: 1.0
name: (S)-Hydroxydecanoyl-CoA
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:28325

metaR r0202
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: true

metaR DADAe
is: SBO:0000176
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
modifier: MODEL1310110009#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110009#
name: Deoxyadenosine deaminase, extracellular
is version of: http://identifiers.org/ec-code/3.5.4.4
kinetic law: MODEL1310110009#
fast: false
reversible: false
product: MODEL1310110009#

metaR DHCR243r
is described by: ECO:0000134
reactant: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
name: 24-dehydrocholesterol reductase [Precursor]
fast: false
modifier: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.72
reversible: false
kinetic law: MODEL1310110009#

metaR GLYtm
reversible: true
product: MODEL1310110009#
name: glycine passive transport to mitochondria
reactant: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110009#

metaM HC01223 m
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
boundary condition: false
is: CHEBI:57340
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_b08b8c93_7f27_4bf9_a2e3_b0c1525b91f9
constant: false
is: Q8TD20
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:154091
initial concentration: NaN
name: SLC2A12
type: Species
initial amount: NaN

metaR NDPK4n
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
reversible: true
is described by: ECO:0000304
reactant: MODEL1310110009#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
product: MODEL1310110009#
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110009#
is: SBO:0000176

metaM idp n
boundary condition: false
is: CHEBI:58280
initial amount: NaN
initial concentration: 1.0
name: IDP(3-)
type: Species
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: HMDB03335
constant: false
has only substance units: false
is: SBO:0000247

metaR O2Stm
is described by: ECO:0000000
name: superoxide anion transport via diffusion (mitochondria)
kinetic law: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
product: MODEL1310110009#
is: SBO:0000185
fast: false
reversible: true

metaM leuleu e
is: http://identifiers.org/pubchem.compound/94244
initial amount: NaN
boundary condition: false
name: Leucylleucine
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C12H24N2O3 CHARGE: 0
type: Species
constant: false
is: SBO:0000247

metaM ksii core4 deg1 l
initial concentration: 1.0
is: CHEBI:57737
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: HMDB00868
type: Species
initial amount: NaN
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
name: keratan sulfate II (core 4-linked), degradation product 1

metaR FUM
is described by: ECO:0000000
name: fumarase
modifier: MODEL1310110009#
is: SBO:0000176
reactant: MODEL1310110009#
product: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/4.2.1.2
type: Reaction
reversible: true

metaR r2322
reactant: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110009#
fast: false
is described by: ECO:0000000

metaM fuc L c
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00174
is: SBO:0000247
type: Species
name: L-fucose
is: CHEBI:18287
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_63bdfef1_f9e6_46ef_a549_df472c290e0a
initial concentration: NaN
is: SBO:0000252
constant: false
name: FPGS
is: Q05932
is encoded by: hsa:2356
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species

metaR RTOTALFATPc
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

metaR MTHFCm
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110009#
reversible: true
modifier: MODEL1310110009#
fast: false
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
is version of: http://identifiers.org/ec-code/6.3.4.3
is described by: ECO:0000269
reactant: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.5.4.9

metaM HC01162 c
boundary condition: false
constant: false
type: Species
is: CHEBI:58376
is: SBO:0000247
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
initial concentration: 1.0
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_10817c22_0688_4e43_b195_687a3bcf32a4
type: Species
name: DLD:DLST:OGDH:PDHX
has part: B4E3E9
is: SBO:0000297
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4967

metaM docosahexcoa m
constant: false
is: SBO:0000247
name: 3,7,10,13,16,19-docosahexenoylcoa
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
type: Species

metaR r2323
is described by: ECO:0000000
reactant: MODEL1310110009#
reversible: true
kinetic law: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
fast: false
product: MODEL1310110009#

metaM prostgi2 c
is: CHEBI:57403
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: prostaglandin I2(1-)
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: HMDB01335

metaM ksi deg20 l
name: keratan sulfate I, degradation product 20
boundary condition: false
is: HMDB00143
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:12936
initial concentration: 1.0

metaR GLYtp
type: Reaction
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
name: glycine passive transport to peroxisome
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000000

metaM c226crn m
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB06510
name: cervonyl carnitine
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
boundary condition: false
is: http://identifiers.org/pubchem.compound/127055

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

metaR SUCCt4 2
reversible: true
kinetic law: MODEL1310110009#
product: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110009#
name: succinate transport via sodium symport
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
is described by: ECO:0000269

metaM o2s e
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false
name: superoxide
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:18421
has only substance units: false
is: HMDB02168

http://identifiers.org/biomodels.db/MODEL1310110009#_f98d2923_051f_453a_9e2a_1a0aa82e0fdd
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:T83654
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
name: _T83654_1_c

http://identifiers.org/biomodels.db/MODEL1310110009#_dba82d79_87e5_4286_a5ff_8ce8c3c439ad
type: Species
initial amount: NaN
name: INPP4A
is: SBO:0000252
is encoded by: hsa:3631
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_9447e171_9eff_43cd_b917_1a46a3d55c64
name: SLC16A10
is encoded by: hsa:117247
initial concentration: NaN
is: SBO:0000252
is: Q8TF71
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: true

metaM dcacoa c
is: HMDB06404
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: Decanoyl-CoA (n-C10:0CoA)
boundary condition: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
has only substance units: false
is: SBO:0000247
is: C05274
is: CHEBI:61430

http://identifiers.org/biomodels.db/MODEL1310110009#_d24dae3a_36ed_4a88_ba13_52a593fb8c3e
constant: false
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:D87002
name: _D87002_1_m
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_800c3b62_b446_4595_bd17_f199a9244cbb
initial amount: NaN
type: Species
is: P52789
constant: false
has only substance units: false
initial concentration: NaN
name: HK2
is encoded by: hsa:3099
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_202143ed_cf10_4258_b2dc_bfe6eb2728c3
initial concentration: NaN
has part: Q96RQ3
is encoded by: hsa:64087
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:56922
has part: Q9HCC0
is: SBO:0000297
initial amount: NaN
type: Species
name: MCCC1:MCCC2

metaR It
reversible: true
type: Reaction
kinetic law: MODEL1310110009#
name: Iodide uniport
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000185
fast: false
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
is described by: ECO:0000269

metaM leuktrC4 c
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
initial concentration: 1.0
is: HMDB01198
type: Species
is: CHEBI:57973
initial amount: NaN
constant: false
has only substance units: false
name: leukotriene C4(2-)
boundary condition: false
is: SBO:0000247

metaM sbcoa c
is: C02838
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
is: HMDB00791
name: suberylcoa
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_9d55a807_5dde_4cda_bf8f_ded4d787fe6d
is encoded by: hsa:5052
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
name: PRDX1

metaR r2320
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110009#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
fast: false
kinetic law: MODEL1310110009#
product: MODEL1310110009#

metaM fuc L e
initial concentration: 1.0
initial amount: NaN
name: L-fucose
is: HMDB00174
boundary condition: false
is: CHEBI:18287
constant: false
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_2cd7654e_b71d_43b3_96ec_8771afdfd0f4
boundary condition: true
constant: false
initial amount: NaN
name: ESCO1
is encoded by: hsa:114799
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q5FWF5
type: Species

metaR S23T2g
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.99.4
type: Reaction
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
reactant: MODEL1310110009#
reversible: false
fast: false
modifier: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000176

metaR FAOXC2051843m
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
is: SBO:0000176
modifier: MODEL1310110009#
fast: false
is described by: ECO:0000000
name: Beta oxidation of fatty acid
reactant: MODEL1310110009#

metaR LCADi D
is described by: ECO:0000304
reversible: false
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
product: MODEL1310110009#
is: SBO:0000176
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.36
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
name: lactaldehyde dehydrogenase
fast: false

metaM CE5586 c
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:58732
type: Species
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
initial concentration: 1.0
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
constant: false
boundary condition: false

metaR GPIAT
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000269
modifier: MODEL1310110009#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110009#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
name: glucosaminylphosphatidyl inositol acetyltransferase

metaR FAOXC121x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:1)x
type: Reaction

metaM ahcys e
constant: false
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:16680
is: SBO:0000247
name: S-Adenosyl-L-homocysteine
initial concentration: 1.0
notes: FORMULA: C14H20N6O5S CHARGE: 0
is: C00021
is: HMDB00939
initial amount: NaN

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_07383822_89ea_4349_a251_07d535a543f6
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: OXSM
is: SBO:0000252
is encoded by: hsa:54995
type: Species
is: Q9NWU1
has only substance units: false
constant: false

metaM strdnccoa m
is: SBO:0000247
is: C16163
has only substance units: false
name: stearidonyl coenzyme A
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/47205473
is: HMDB06519

metaR r2321
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110009#
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110009#

metaM o2s c
is: CHEBI:18421
is: HMDB02168
boundary condition: false
name: superoxide
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704

metaM ksi deg37 l
name: keratan sulfate I, degradation product 37
is: HMDB01354
has only substance units: false
notes: FORMULA: C62H104N4O46 CHARGE: 0
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:57455
is: SBO:0000247
type: Species

metaM 25aics c
is: CHEBI:58443
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
is: C04823
initial concentration: 1.0
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00797
type: Species
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_f5270b94_ab43_4311_a68a_7a5b78a4f781
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: P32119
initial concentration: NaN
name: PRDX2
type: Species
is encoded by: hsa:7001

http://identifiers.org/biomodels.db/MODEL1310110009#_9ebd5907_c159_4590_a38a_008548fa224c
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: Q7LGC8
is: SBO:0000252
name: CHST3
is encoded by: hsa:9469
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_0fdc4496_7c28_42b7_8736_98b1dde4b10c
name: NDUFS6
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:4726
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q6IBC4

http://identifiers.org/biomodels.db/MODEL1310110009#_69166107_3b95_4d56_bc78_77a11da93225
is: SBO:0000252
is encoded by: hsa:5335
type: Species
is: P19174
boundary condition: true
name: PLCG1
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_38cfe516_a3fa_425f_9076_75698aa58b26
is encoded by: hsa:AI291895
has only substance units: false
type: Species
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: _AI291895_1_c

http://identifiers.org/biomodels.db/MODEL1310110009#_9cab8b0c_8d53_42b8_a7f3_b2cfa5e63e1d
has only substance units: false
boundary condition: true
is encoded by: hsa:51227
is: SBO:0000252
is: P57054
type: Species
initial concentration: NaN
constant: false
name: PIGP
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_6a7b94cf_17ba_4664_a4bb_07d6551f55e7
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR r0390
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
is: SBO:0000176
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110009#
product: MODEL1310110009#
fast: false
type: Reaction

metaM leuktrC4 e
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
boundary condition: false
has only substance units: false
initial amount: NaN
name: leukotriene C4(2-)
is: HMDB01198
type: Species
is: CHEBI:57973
constant: false

metaM 3dodtricoa x
initial amount: NaN
is: SBO:0000247
is: C05279
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
name: 3,6,9-dodecatrienoylcoa
is: HMDB11123
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_0b25ca38_ff42_4d65_8a5a_8c08ed2b3af7
is: SBO:0000252
initial concentration: NaN
name: FH
is: P07954
type: Species
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:2271
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_ea329208_8c78_4896_89fa_30b7b407dc8d
has only substance units: false
is encoded by: hsa:1103
is: SBO:0000252
name: CHAT
boundary condition: true
type: Species
is: P28329
initial concentration: NaN
initial amount: NaN
constant: false

metaR BILIRUBt2
fast: false
type: Reaction
name: bilirubin transport via bicarbonate countertransport
product: MODEL1310110009#
is: SBO:0000185
reactant: MODEL1310110009#
reversible: true
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
modifier: MODEL1310110009#

metaM ahcys c
constant: false
is: CHEBI:16680
name: S-Adenosyl-L-homocysteine
is: HMDB00939
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
initial amount: NaN
is: C00021
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_a681e782_d86d_4e9c_b9cc_1a49a1d302f9
boundary condition: true
initial amount: NaN
constant: false
is: Q53Y83
has only substance units: false
is encoded by: hsa:2717
is: SBO:0000252
type: Species
name: GLA
initial concentration: NaN

metaR COAtp
name: coenzyme A transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_bb22ed4e_d3b5_45f9_a3d6_01bd2025e56e
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:3613
boundary condition: true
is: O14732
constant: false
name: IMPA2
type: Species
initial concentration: NaN

metaM cs a deg2 l
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C37H55NO38S2 CHARGE: -4
constant: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2
is: HMDB00127
is: CHEBI:15748

metaR r2326
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaR XOL7AH2tm
kinetic law: MODEL1310110009#
reversible: true
product: MODEL1310110009#
is: SBO:0000185
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_f0afc15c_a28c_4f29_a1ff_376fecb57922
is encoded by: hsa:400410
initial concentration: NaN
name: ST20
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is: Q9HBF5
initial amount: NaN
has only substance units: false

metaR PRPNCOAHYDm
type: Reaction
reactant: MODEL1310110009#
modifier: MODEL1310110009#
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.18
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
name: Propenoyl-CoA hydrolase (m)

metaM hs deg1 l
has only substance units: false
is: HMDB01352
constant: false
type: Species
name: heparan sulfate, degradation product 1
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:17180

metaR THRCYSNaEx
type: Reaction
is: SBO:0000185
name: L-cysteine/L-threonine Na-dependent exchange (Thr-L in)
fast: false
reversible: false
reactant: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000269
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaR GGLUCT
name: gamma-glutamylcyclotransferase
is version of: http://identifiers.org/ec-code/2.3.2.4
type: Reaction
modifier: MODEL1310110009#
reversible: false
reactant: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
kinetic law: MODEL1310110009#
product: MODEL1310110009#
fast: false
is described by: ECO:0000269

metaM clpn hs c
type: Species
notes: FORMULA: CHARGE: 0
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
name: clpn_hs[c]
has only substance units: false
boundary condition: false
is: CHEBI:21338
is: HMDB02704

metaR r0666
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.2.4.2
reversible: true
type: Reaction
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
fast: false

metaR CMPSAS
name: CMP sialic acid synthase
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.7.43
fast: false
is described by: ECO:0000304
reactant: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
reversible: false

metaM sphmyln hs c
is: CHEBI:58216
name: sphingomyelin betaine
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species

metaM rib D e
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: HMDB00283
initial amount: NaN
constant: false
has only substance units: false
type: Species
name: D-ribose
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:16988

metaR r2327
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
kinetic law: MODEL1310110009#
is: SBO:0000185
reactant: MODEL1310110009#
product: MODEL1310110009#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000

metaR DESAT22 1p
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
reversible: false
product: MODEL1310110009#
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_adcc0b7d_3dfa_4acd_848e_2d08239c35c9
constant: false
is: B7Z428
name: GNE
is encoded by: hsa:10020
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN

metaR CHOLtu
kinetic law: MODEL1310110009#
is: SBO:0000185
modifier: MODEL1310110009#
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
name: Choline uniport
reversible: true

metaR LEUKTRB4t
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110009#
name: leukotriene B4 transport
product: MODEL1310110009#
reversible: true

metaM naglc2p U c
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:18278
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C1105H1810N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
type: Species
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human uterine homolog
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_1769b2fd_7467_4d6a_b52e_74257911aa66
is encoded by: hsa:8875
initial amount: NaN
constant: false
is encoded by: hsa:8876
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:55350
is: SBO:0000297
name: VNN3:VNN2:VNN1
has part: O95497
has part: A8K7W0

metaR ADCim
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
reactant: MODEL1310110009#
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110009#
is: SBO:0000176
name: Acetoacetate decarboxylation (irreversible), mitochondrial

metaR MANt1r
reversible: true
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
name: mannose transport (uniport)
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
modifier: MODEL1310110009#

metaM 3dodtricoa m
initial amount: NaN
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
name: 3,6,9-dodecatrienoylcoa
is: HMDB11123
is: C05279
has only substance units: false
boundary condition: false
constant: false
type: Species

metaM 4izp c
initial concentration: 1.0
type: Species
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
has only substance units: false
initial amount: NaN
is: HMDB01014
constant: false
name: 4-Imidazolone-5-propanoate
is: SBO:0000247
boundary condition: false
is: CHEBI:57255

metaR COAtr
reversible: true
type: Reaction
fast: false
name: COA transporter, endoplasmic reticulum
reactant: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110009#

metaM itaccoa m
is: CHEBI:57381
is: HMDB03377
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: itaconyl-CoA(5-)
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
initial amount: NaN
constant: false

metaR BALAVECSEC
type: Reaction
kinetic law: MODEL1310110009#
is described by: ECO:0000269
name: B-alanine secretion via secretory vesicle (ATP driven)
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (140679.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750892,PMID:15383652 NOTES:SAB This reaction represents the ATP driven secretion of glu from the cell. It leaves out the vesicle because a compartment is not available for that. ATP demand is not known for sure stoichiometrically, but 1:1 H coupling ratio is assumed, which could translate to 3 b-ala/ATP.
modifier: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
reversible: false
is: SBO:0000185

metaR FAOXC163C142x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)x
type: Reaction

metaM 4abut n
name: 4-Aminobutanoate
constant: false
is: HMDB00112
type: Species
is: C00334
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0

metaR r2324
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110009#
product: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true

metaR FAOXC184x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_2cce7750_8f00_4e6d_a663_337a56504fd1
is encoded by: hsa:10568
name: SLC34A2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: O95436
boundary condition: true
initial amount: NaN
constant: false
type: Species

metaR r2325
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110009#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM hdd2coa x
boundary condition: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
constant: false
is: CHEBI:61526
initial amount: NaN
is: HMDB03945
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: (E)-hexadec-2-enoyl-CoA(4-)
type: Species

metaM succ x
is: HMDB00254
type: Species
is: C00042
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: CHEBI:30031
name: Succinate
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_39e47150_ad37_4779_ab14_44606e4505d8
has only substance units: false
is: Q709F0
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: ACAD11
type: Species
initial concentration: NaN
is encoded by: hsa:84129
constant: false

metaR r0669
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
type: Reaction
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
kinetic law: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110009#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110009#_e7440195_51a2_4e03_82a9_98df7d682d84
boundary condition: true
type: Species
name: COX7A1
is: P24310
is encoded by: hsa:1346
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM strdnccoa c
is: SBO:0000247
is: C16163
name: stearidonyl coenzyme A
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: HMDB06519
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205473

metaM sql r
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
is: SBO:0000247
constant: false
initial amount: NaN
name: squalene
is: CHEBI:15440
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00256
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_422e57c8_fbb0_40dc_b8ff_de0348365ff0
is encoded by: hsa:3251
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: P00492
is: SBO:0000252
has only substance units: false
name: HPRT1
initial amount: NaN

metaM methf c
constant: false
is: C00445
type: Species
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
boundary condition: false
is: CHEBI:57455
is: HMDB01354
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: 5,10-Methenyltetrahydrofolate

metaR ADPACDAc
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of adipic acid for formation of adipoyl carnitine
type: Reaction

metaR GALASE3ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
fast: false
is described by: ECO:0000000
product: MODEL1310110009#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5

http://identifiers.org/biomodels.db/MODEL1310110009#_74b51310_6446_4bd8_bf72_675aa21828cb
name: SLC24A2
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q9UI40
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:25769

metaR r0517
type: Reaction
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
reactant: MODEL1310110009#
modifier: MODEL1310110009#
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000176
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110009#_fabd3a32_179e_455a_b679_03d61bea2540
is: O75106
name: AOC2
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:314
constant: false

metaR GGH 5DHFl
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (5DHF), lysosomal
product: MODEL1310110009#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
reactant: MODEL1310110009#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000176

metaM sphmyln hs g
type: Species
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
initial concentration: 1.0
has only substance units: false
name: sphingomyelin betaine
boundary condition: false
initial amount: NaN
is: CHEBI:58216
is: SBO:0000247
constant: false

metaM HC01399 m
is: CHEBI:27466
is: SBO:0000247
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: (S)-3-Hydroxytetradecanoyl-CoA
constant: false
boundary condition: false

metaR r1774
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110009#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
is: SBO:0000185
fast: false
reversible: false
type: Reaction

metaM fuc L l
initial concentration: 1.0
is: CHEBI:18287
name: L-fucose
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
initial amount: NaN
constant: false
is: HMDB00174
type: Species

metaM HC00319 m
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial amount: NaN
type: Species
name: Malonate
is: CHEBI:30794
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_b5f8fc90_133d_48ce_938b_d2a35bf50aa8
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:5143
is: Q7KYS4
type: Species
is: SBO:0000252
name: PDE4C
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_ada0fdb5_e658_4148_b0eb_33b1ea7bee8a
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is: Q9NS82
type: Species
name: SLC7A10
initial concentration: NaN
is encoded by: hsa:56301
has only substance units: false

metaR HACD1m
reversible: true
modifier: MODEL1310110009#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110009#
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
fast: false
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction

metaR NAGA2ly
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
type: Reaction
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.49
reactant: MODEL1310110009#
reversible: false
fast: false
is described by: ECO:0000000
name: N-acetylgalactosaminidase, alpha-

metaR r0514
product: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:
name: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
type: Reaction
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110009#

metaR PTDCAt
type: Reaction
reversible: true
reactant: MODEL1310110009#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
name: fatty acid transport via diffusion

metaM retn r
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
name: all-trans-retinoate
is: CHEBI:35291
initial concentration: 1.0
has only substance units: false
is: HMDB01852

metaR r2328
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
fast: false
reactant: MODEL1310110009#
product: MODEL1310110009#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR COAtn
product: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
fast: false
name: coenzyme A transport, nuclear

http://identifiers.org/biomodels.db/MODEL1310110009#_c5b0c84e_7e7b_4cb7_a081_30f9880bc6fd
name: LDHD
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:197257
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false

metaR r0668
reversible: true
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
fast: false
kinetic law: MODEL1310110009#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.2.19
is described by: ECO:0000000
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_12997f10_d81d_4ef2_8e47_5a73faf343dd
name: SPHK2
is encoded by: hsa:56848
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q9NRA0
type: Species
constant: false
initial concentration: NaN

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR EX crvnc LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC22:6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_04ed3bc5_c22f_49fc_976a_4690f690cb03
has only substance units: false
boundary condition: true
name: _R06874_1_r
initial concentration: NaN
type: Species
is encoded by: hsa:R06874
initial amount: NaN
constant: false
is: SBO:0000252

metaM pyam5p c
is: SBO:0000247
is: CHEBI:58451
initial concentration: 1.0
type: Species
initial amount: NaN
name: Pyridoxamine 5'-phosphate
is: C00647
boundary condition: false
notes: FORMULA: C8H12N2O5P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00475 EHMN_ABBREVIATION: C00647
constant: false
is: HMDB01555
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_500f7cce_f194_48de_a06b_ed9e18697500
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:5151
boundary condition: true
name: PDE8A
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_4ea19c39_497e_4e96_9e62_56fb9bb22cd9
type: Species
is encoded by: hsa:51095
initial amount: NaN
name: TRNT1
is: SBO:0000252
is: Q96Q11
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_7620ae32_1e40_48f2_a933_386434b9f440
constant: false
is encoded by: hsa:5158
type: Species
initial concentration: NaN
is: B7Z9T9
is: SBO:0000252
has only substance units: false
boundary condition: true
name: PDE6B
initial amount: NaN

metaM dcacoa m
name: Decanoyl-CoA (n-C10:0CoA)
initial concentration: 1.0
is: CHEBI:61430
is: HMDB06404
constant: false
is: C05274
has only substance units: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_3ded7e27_9ea8_4bc6_84e2_2d0d8dd503ef
initial amount: NaN
is encoded by: hsa:3423
name: IDS
initial concentration: NaN
constant: false
is: SBO:0000252
is: P22304
type: Species
has only substance units: false
boundary condition: true

metaR r2329
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110009#
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR COAtm
name: CoA transporter
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
product: MODEL1310110009#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#
is described by: ECO:0000269
modifier: MODEL1310110009#

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_e8e37622_1f9d_4e8b_af37_9ea9746167c5
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:65263
type: Species
name: PYCRL
initial concentration: NaN
is: Q53H96
initial amount: NaN

metaR r1772
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110009#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
is: SBO:0000185
reversible: false
fast: false

metaM arab L e
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00646
name: L-arabinose
initial amount: NaN
is: CHEBI:30849
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110009#_8bf77e33_f1ad_41ae_a699_0b8090a50fc3
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:54344
is: Q9P2X0
boundary condition: true
constant: false
initial concentration: NaN
name: DPM3

metaM 4nphsf e
name: 4-Nitrophenyl sulfate
initial amount: NaN
is: SBO:0000247
is: HMDB06492
is: CHEBI:35422
has only substance units: false
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
boundary condition: false
type: Species
constant: false
initial concentration: 1.0

metaM adn c
has only substance units: false
initial amount: NaN
name: Adenosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
initial concentration: 1.0
boundary condition: false
is: CHEBI:16335
is: SBO:0000247
constant: false
is: HMDB00050
is: C00212
type: Species

metaM ump e
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57865
has only substance units: false
type: Species
is: HMDB00288
initial concentration: 1.0
name: UMP(2-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_3b815c9c_6ff2_4e36_90e1_07fc47d0bd7f
boundary condition: true
is encoded by: hsa:84812
is: SBO:0000252
is: Q9BRC7
name: PLCD4
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
constant: false

metaM octe5coa x
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
is: SBO:0000247
boundary condition: false
constant: false
name: 5-octenoylcoa
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_984f61e6_7d86_4a04_b817_2bb3f82ba310
constant: false
boundary condition: true
is encoded by: hsa:7359
type: Species
name: _7359_1_c
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR SUBERCROT
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_85f146dc_6acc_45ec_a094_8bcabce76e9f
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: _AI631997_1_m
is encoded by: hsa:AI631997
type: Species
boundary condition: true
constant: false
has only substance units: false

metaR UDPACGALtl
fast: false
kinetic law: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
type: Reaction
name: udpacgal intracellular transport
reactant: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
reversible: true

metaM o2 c
initial amount: NaN
constant: false
type: Species
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:15379
is: C00007

metaM pmtcoa x
initial amount: NaN
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB01338
has only substance units: false
type: Species
is: SBO:0000247
is: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
is: CHEBI:57379

metaM apoC Lys btn c
boundary condition: false
constant: false
notes: FORMULA: C16H27N4O3SX CHARGE: 0
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00182
initial concentration: 1.0
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
type: Species
is: CHEBI:32551

metaM 3hexdtricoa x
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB02288
name: 3,7,10-hexadecatrienoylcoa

metaR GALASE17ly
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110009#
name: beta-galactosidase, lysosomal
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
reversible: false
product: MODEL1310110009#

metaM xtsn c
boundary condition: false
constant: false
is: CHEBI:18107
initial concentration: 1.0
type: Species
is: HMDB00299
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
is: SBO:0000247
initial amount: NaN
name: xanthosine
has only substance units: false

metaR CORE6GTg
name: Core 6 beta-GlcNAc-transferase A, Golgi apparatus
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2650.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
product: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.102
reversible: false
is described by: ECO:0000000

metaR UMPK
fast: false
kinetic law: MODEL1310110009#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
reactant: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: UMP kinase
modifier: MODEL1310110009#
is: SBO:0000176

metaR GLXtp
reversible: true
fast: false
product: MODEL1310110009#
kinetic law: MODEL1310110009#
name: glyoxylate transport, peroxisomal
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110009#

metaR r1010
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110009#
type: Reaction
name: Postulated transport reaction
reactant: MODEL1310110009#
fast: false
product: MODEL1310110009#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaM dhcholestancoa x
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
boundary condition: false
constant: false
initial amount: NaN
is: HMDB02159
has only substance units: false
is: CHEBI:15494
type: Species
is: SBO:0000247
initial concentration: 1.0
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA

metaR MAGt
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:10344773 NOTES:
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110009#
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110009#
name: monoacylglycerol 2 transport

http://identifiers.org/biomodels.db/MODEL1310110009#_15cc1904_c53c_43a0_85bf_5eaf10347a9d
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
name: ATP5D
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:513

metaM ksi deg3 l
is: SBO:0000247
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
is: HMDB01356
constant: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 3
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:57312

http://identifiers.org/biomodels.db/MODEL1310110009#_4b66d1b0_25df_43d3_9681_d237d44b2e66
type: Species
boundary condition: true
initial amount: NaN
constant: false
name: HK1
is: Q59FD4
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3098

metaR PPItx
reversible: true
name: Diphosphate transporter, peroxisome
is described by: ECO:0000000
reactant: MODEL1310110009#
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

http://identifiers.org/biomodels.db/MODEL1310110009#_5591ed13_7610_47b0_9b8c_828b44c89818
has only substance units: false
is: Q6FGV9
initial amount: NaN
name: PMVK
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10654

metaR r1011
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
is: SBO:0000185
reactant: MODEL1310110009#
product: MODEL1310110009#
reversible: false
is described by: ECO:0000000
name: Transport reaction
fast: false

metaM ump c
is: HMDB00288
name: UMP
constant: false
initial amount: NaN
is: CHEBI:57865
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: C00105
initial concentration: 1.0
type: Species
boundary condition: false

metaR FAEL204
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110009#
name: fatty-acyl-CoA elongation (n-C20:4CoA)
kinetic law: MODEL1310110009#
fast: false
product: MODEL1310110009#
type: Reaction
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
reversible: false

metaM c12dccoa c
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
has only substance units: false
name: dodecanedioylcoa
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB00623

metaR ACt2m
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110009#
is: SBO:0000185
reversible: true
name: acetate mitochondrial transport via proton symport
kinetic law: MODEL1310110009#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_82e196b4_95ff_4378_ac98_e63adeedd022
is: Q9UNU6
type: Species
is encoded by: hsa:1582
is: SBO:0000252
name: CYP8B1
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_11dea7a1_44cd_4aad_bb01_937ad8dca621
initial concentration: NaN
is: SBO:0000252
name: PDE9A
type: Species
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:5152
initial amount: NaN

metaR r0408
product: MODEL1310110009#
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.4.3.5
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110009#
reversible: true
modifier: MODEL1310110009#
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
is described by: ECO:0000000

metaR Q10H2e
fast: false
is: SBO:0000185
reactant: MODEL1310110009#
product: MODEL1310110009#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
name: transport of ubiquinol into lymph
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_332fe9db_83f4_4cec_8f8d_834cb857c3c3
initial amount: NaN
name: PIK3R1
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:5295
is: B3KT19
is: SBO:0000252
has only substance units: false
constant: false

metaR PEt
is: SBO:0000185
kinetic law: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
fast: false
name: phosphatidylethanolamine transport
reversible: true
reactant: MODEL1310110009#
product: MODEL1310110009#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_dc057fa9_9de4_44fe_bc4b_84aa2692a6a5
type: Species
constant: false
name: _AA526438_1_c
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:AA526438
has only substance units: false
initial concentration: NaN

metaM o2 e
initial amount: NaN
constant: false
type: Species
is: HMDB01377
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
name: O2
initial concentration: 1.0
is: C00007
boundary condition: false
is: CHEBI:15379
has only substance units: false

metaR GLCNACASE5ly
name: alpha-N-acetylglucosaminidase, lysosomal
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.50
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110009#
reversible: false
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
fast: false
type: Reaction

metaR FAOXC161C141x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C16:1-->C14:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_78f20aa0_b3c0_4bea_bd32_ec2d2399d4ba
has only substance units: false
is encoded by: hsa:AI601100
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: _AI601100_1_m
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_69e80319_c547_4ff8_9865_9fa960130a86
type: Species
initial amount: NaN
name: ETFB
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2109
is: SBO:0000252
constant: false
has only substance units: false

metaR r1012
fast: false
reversible: false
type: Reaction
product: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110009#_86e8cab4_6e64_4367_889e_b840013beadf
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: P49902
name: NT5C2
has only substance units: false
is encoded by: hsa:22978
type: Species
constant: false

metaR LPS4e
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.1.1.4
notes: GENE_ASSOCIATION: (50487.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10713052 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
name: phospholipase
fast: false
reversible: false
reactant: MODEL1310110009#

metaR r0407
kinetic law: MODEL1310110009#
fast: false
is: SBO:0000176
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
type: Reaction
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.4.3.5
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110009#

metaR FOLt2le
name: folate transport via anion exchange
reactant: MODEL1310110009#
is described by: ECO:0000134
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_f6b94445_64bb_4ff6_9a17_85afb6cd81a7
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is: O15305
is encoded by: hsa:5373
is: SBO:0000252
constant: false
initial amount: NaN
name: PMM2

metaM CE0693 m
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
name: 3-oxolaur-6-cis-enoyl-CoA
is: CHEBI:28387
is: SBO:0000247
boundary condition: false
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
has only substance units: false
is: HMDB11123

http://identifiers.org/biomodels.db/MODEL1310110009#_e9908113_8fbc_46cf_bc19_f1e52c5d486c
type: Species
is: Q15181
is encoded by: hsa:5464
initial concentration: NaN
name: PPA1
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false

metaM 3hexdtetcoa m
name: 3,7,10,13-hexadecatetraenoylcoa
initial amount: NaN
has only substance units: false
is: HMDB02288
is: SBO:0000247
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
boundary condition: false
type: Species
initial concentration: 1.0
constant: false

metaR r1013
kinetic law: MODEL1310110009#
is: SBO:0000185
type: Reaction
reversible: false
product: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
is described by: ECO:0000000

metaM cholcoads x
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
has only substance units: false
is: HMDB06889
is: CHEBI:27505
constant: false
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR r0717
type: Reaction
product: MODEL1310110009#
reversible: false
fast: false
is described by: ECO:0000000
reactant: MODEL1310110009#
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110009#

metaR SUCOASm
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/6.2.1.5
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110009#
type: Reaction
reversible: true
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
fast: false
is described by: ECO:0000000
name: Succinate--CoA ligase (ADP-forming)
product: MODEL1310110009#
is: SBO:0000176

metaR HMGCOARc
product: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.34
modifier: MODEL1310110009#
type: Reaction
fast: false
is described by: ECO:0000134
reversible: false
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110009#_e34a7efb_f4f9_4855_98ee_3e9a28477352
is: O60312
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
name: ATP10A
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:57194

metaM tcynt e
constant: false
type: Species
is: CHEBI:18022
has only substance units: false
name: thiocyanate
initial amount: NaN
is: HMDB01453
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
boundary condition: false

metaM dopa e
has only substance units: false
is: CHEBI:59905
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00073
type: Species
name: dopaminium(1+)
initial concentration: 1.0
boundary condition: false

metaM 4mzym int1 r
is: HMDB06927
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: 4-Methylzymosterol intermediate 1

http://identifiers.org/biomodels.db/MODEL1310110009#_ff238531_a0b9_4d65_b01e_51d59c765013
is encoded by: hsa:83594
type: Species
has only substance units: false
initial amount: NaN
name: NUDT12
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q9BQG2

metaM itp e
name: ITP(3-)
initial amount: NaN
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: SBO:0000247
is: CHEBI:57614
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
boundary condition: false
is: HMDB00189

http://identifiers.org/biomodels.db/MODEL1310110009#_51225c9a_32f7_4ac1_abab_830536b32286
initial amount: NaN
initial concentration: NaN
is: P33908
name: MAN1A1
is: SBO:0000252
constant: false
is encoded by: hsa:4121
has only substance units: false
boundary condition: true
type: Species

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR r1014
reversible: false
type: Reaction
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
name: Postulated transport reaction
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaR FAOXC16080m
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
product: MODEL1310110009#
reversible: false
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
fast: false
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110009#

metaR EX pydx LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Pyridoxal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_6df9ba73_15a1_4acd_ab73_897f05fc2f32
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
constant: false
name: ELOVL6
has only substance units: false
initial amount: NaN
is: Q9H5J4
is encoded by: hsa:79071

http://identifiers.org/biomodels.db/MODEL1310110009#_1871efd8_9938_415a_aaf2_5c8b09d9fd7f
boundary condition: true
is: Q6ZWP6
has only substance units: false
name: ACAD8
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:27034
initial concentration: NaN

metaR r0716
reactant: MODEL1310110009#
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000

metaM pi e
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
is: C00009
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00973
type: Species
name: hydrogenphosphate
boundary condition: false
has only substance units: false

metaR DADA
reactant: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
is described by: ECO:0000269
modifier: MODEL1310110009#
name: Deoxyadenosine deaminase
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.5.4.4
kinetic law: MODEL1310110009#
reversible: false
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_3196a057_8417_4718_87c9_9b6ab9e631b3
boundary condition: true
is encoded by: hsa:37
name: ACADVL
type: Species
is: P49748
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR DHCR71r
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.21
name: 7-dehydrocholesterol reductase
reversible: false
type: Reaction
is described by: ECO:0000134
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_299c712a_2abd_4084_b7df_1af9f84c97b3
constant: false
name: ALDH3B2
has only substance units: false
is encoded by: hsa:222
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: P48448

http://identifiers.org/biomodels.db/MODEL1310110009#_8ba34e7f_99b9_420e_8a9c_5996d4d1242f
initial amount: NaN
initial concentration: NaN
name: SLC27A1
type: Species
constant: false
boundary condition: true
is: Q6PCB7
is encoded by: hsa:376497
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_5cec6179_8333_4468_b1dd_980641767093
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:728226
name: _728226_1_m
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_9a6f2893_4b9c_4fbf_888b_3e9963139b9f
initial concentration: NaN
is encoded by: hsa:AV717590
constant: false
name: _AV717590_1_c
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_29e49f3d_c81c_4772_870f_5b584f80d185
has only substance units: false
initial amount: NaN
name: SLC27A1
is: SBO:0000252
is encoded by: hsa:376497
type: Species
boundary condition: true
initial concentration: NaN
constant: false

metaM tcynt c
has only substance units: false
constant: false
type: Species
name: thiocyanate
is: CHEBI:18022
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB01453
is: SBO:0000247

metaM glyc m
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: C00116
is: CHEBI:17754
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00131
name: Glycerol

metaM sebacid c
name: sebacicacid
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: C08277
type: Species
notes: FORMULA: C10H16O4 CHARGE: -2
boundary condition: false
is: HMDB00792
initial amount: NaN
constant: false

metaR SPODMm
name: superoxide dismutase
is version of: http://identifiers.org/ec-code/1.15.1.1
fast: false
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
is: SBO:0000176
reactant: MODEL1310110009#
is described by: ECO:0000304
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
reversible: false

metaR FAOXC102m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

metaM 4h2oglt m
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
is: HMDB02070
is: CHEBI:17742
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
name: 4-hydroxy-2-oxoglutarate(2-)
constant: false

metaM 4nphsf c
is: HMDB06492
initial amount: NaN
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
is: CHEBI:35422
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
name: 4-Nitrophenyl sulfate

metaR AKR1D2
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.3.1.3
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
reactant: MODEL1310110009#
reversible: false
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
kinetic law: MODEL1310110009#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110009#

metaR BAMPPALDOX
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.2.1.36
kinetic law: MODEL1310110009#
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
is: SBO:0000176
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
reactant: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
fast: false

metaM itp c
is: CHEBI:57614
has only substance units: false
boundary condition: false
is: HMDB00189
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
name: ITP(3-)
initial concentration: 1.0
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081

metaM adpcoa c
constant: false
type: Species
name: adipoylcoa
is: SBO:0000247
is: C14143
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
is: HMDB04047
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_ab29cf37_4584_45f0_a3be_a4ae8de7a0de
is encoded by: hsa:4712
name: NDUFB6
initial amount: NaN
is: O95139
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true

metaR ACt2r
reactant: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
product: MODEL1310110009#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110009#
name: acetate reversible transport via proton symport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_241f15bb_5ac7_42a5_9a53_058cf5e94c62
name: GALNT9
is: Q9HCQ5
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:50614
initial concentration: NaN
boundary condition: true
type: Species
constant: false

metaR PRO Dtde
reversible: true
reactant: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110009#
fast: false
name: D-proline transport, extracellular
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.

metaR SPODMn
modifier: MODEL1310110009#
reversible: false
is: SBO:0000176
reactant: MODEL1310110009#
name: superoxide dismutase, nuclear
kinetic law: MODEL1310110009#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
fast: false
product: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/1.15.1.1

http://identifiers.org/biomodels.db/MODEL1310110009#_fb790b8c_2277_4e17_9787_6cc45198ccb8
initial concentration: NaN
is: Q9HC21
initial amount: NaN
is encoded by: hsa:60386
name: SLC25A19
type: Species
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false

metaM pi g
name: hydrogenphosphate
is: SBO:0000247
has only substance units: false
is: CHEBI:43474
initial amount: NaN
constant: false
is: HMDB00973
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
type: Species
boundary condition: false

metaR r0718
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
type: Reaction
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.181
kinetic law: MODEL1310110009#
product: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000000
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reactant: MODEL1310110009#

metaR Ser Thrtg
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110009#
name: Ser/Thr transport (from golgi to lysosome)
reactant: MODEL1310110009#
product: MODEL1310110009#

metaR ST8SIA12
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.99.8
name: Beta-galactoside alpha-2,3-sialyltransferase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
modifier: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
reversible: false
fast: false
product: MODEL1310110009#
reactant: MODEL1310110009#

metaR BUP2
is: SBO:0000176
name: beta-ureidopropionase (D-3-amino-isobutanoate forming)
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:11508704,PMID:5773299 NOTES:MM
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.1.6
reactant: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_6ad92029_0e69_4e63_831a_0a4b865a7f45
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: E9PDD5
is encoded by: hsa:3421
type: Species
boundary condition: true
initial concentration: NaN
constant: false
name: IDH3G

metaR MI3PP
product: MODEL1310110009#
name: myo-inositol 3-phosphatase
type: Reaction
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
modifier: MODEL1310110009#
reversible: false
fast: false
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.25

http://identifiers.org/biomodels.db/MODEL1310110009#_d501a4f5_58bc_4152_9b2f_d6665827532e
name: DDC
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
is encoded by: hsa:1644
is: Q53Y41
is: SBO:0000252

metaM ump m
boundary condition: false
initial amount: NaN
is: CHEBI:57865
has only substance units: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
constant: false
is: SBO:0000247
name: UMP(2-)
is: HMDB00288
initial concentration: 1.0

metaM 2octdectecoa x
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
name: 2,6,9,12-octadecatetraenoylcoa
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280355

http://identifiers.org/biomodels.db/MODEL1310110009#_e914bb6f_1c2a_4970_8b4d_b0edfddddf40
initial concentration: NaN
type: Species
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:5145
name: PDE6A
has only substance units: false
is: P16499
is: SBO:0000252

metaM dodecanac c
initial amount: NaN
name: Dodecanedioic acid
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: HMDB00623
notes: FORMULA: C12H20O4 CHARGE: -2
is: SBO:0000247
has only substance units: false

metaM apoC Lys btn m
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C16H27N4O3SX CHARGE: 0
boundary condition: false
is: C05552
is: http://identifiers.org/pubchem.compound/7886
has only substance units: false
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
type: Species
is: HMDB03134
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_34286a13_1a97_4a51_a829_90c6aace9835
name: PRDX2
has only substance units: false
is encoded by: hsa:7001
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_9b7ecda1_5917_4ef6_bbab_9a77ab8960bf
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is: D9HTE9
is encoded by: hsa:6576
initial concentration: NaN
name: SLC25A1
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_98d416d2_946e_4f6b_8167_6c1e8da76e7b
type: Species
constant: false
is: SBO:0000252
is: Q549M5
has only substance units: false
is encoded by: hsa:4718
name: NDUFC2
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR DCSPTN1CRNt
modifier: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110009#
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
reactant: MODEL1310110009#
type: Reaction
name: transport into the mitochondria (carnitine)

metaR CYSGLTH
name: Glutathione:cystine oxidoreductase
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
is described by: ECO:0000000
reactant: MODEL1310110009#
type: Reaction
is: SBO:0000176
product: MODEL1310110009#
kinetic law: MODEL1310110009#

metaR r0068
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (134526.1) SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
type: Reaction
product: MODEL1310110009#
reactant: MODEL1310110009#
modifier: MODEL1310110009#
reversible: false
kinetic law: MODEL1310110009#
name: Acetyl adenylate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1

metaM mhista c
name: N(tele)-methylhistaminium
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:58600
is: HMDB00898
notes: FORMULA: C6H12N3 CHARGE: 1 INCHI: InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3/p+1 EHMN_ABBREVIATION: C05127
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN

metaM arach e
initial concentration: 1.0
constant: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
boundary condition: false
is: HMDB02212
has only substance units: false
initial amount: NaN
is: CHEBI:32360
is: SBO:0000247
type: Species
name: arachidate

metaM ac e
name: acetate
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:30089
is: HMDB00042
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
boundary condition: false

metaM malttr e
has only substance units: false
name: maltotriose
boundary condition: false
is: SBO:0000247
is: C01835
initial concentration: 1.0
type: Species
is: HMDB01262
initial amount: NaN
constant: false
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
is: CHEBI:27931

metaM ump n
type: Species
constant: false
is: SBO:0000247
name: UMP(2-)
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
boundary condition: false
initial concentration: 1.0
is: CHEBI:57865

http://identifiers.org/biomodels.db/MODEL1310110009#_8ad78adf_ab38_4848_bd2e_f9064e529dfb
name: NDUFS8
initial concentration: NaN
is: SBO:0000252
is: O00217
constant: false
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:4728

metaR RE3241R
reversible: false
fast: false
product: MODEL1310110009#
is described by: ECO:0000000
kinetic law: MODEL1310110009#
name: RE3241
modifier: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
reactant: MODEL1310110009#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_f3e933c7_9c56_4105_a3a2_4a83e96f8dd1
initial amount: NaN
name: _T83654_1_e
is encoded by: hsa:T83654
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_4a39f99b_f530_44c0_a5e7_d67aa1cc5f6a
is: E5KSL6
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1716
has only substance units: false
name: DGUOK
boundary condition: true
type: Species

metaR r1380
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
reversible: true
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
reactant: MODEL1310110009#

metaR FAOXC123x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)x
type: Reaction

metaM pro D e
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: D-proline
boundary condition: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
has only substance units: false
is: SBO:0000247
is: CHEBI:16313
is: HMDB03411

http://identifiers.org/biomodels.db/MODEL1310110009#_26cb3950_60fe_4359_9682_4b5d2b747e31
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:5338
name: PLD2
initial amount: NaN
is: SBO:0000252
type: Species
is: O14939

http://identifiers.org/biomodels.db/MODEL1310110009#_8cd04d72_4516_4d12_87ce_e3e76d4c14ba
is encoded by: hsa:2954
is: SBO:0000252
constant: false
name: GSTZ1
boundary condition: true
type: Species
has only substance units: false
is: O43708
initial concentration: NaN
initial amount: NaN

metaR r1018
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110009#
name: Transport reaction

metaM o2 m
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: CHEBI:15379
type: Species
is: HMDB01377
initial amount: NaN
is: C00007
boundary condition: false

metaR AMPDA
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.6
name: Adenosine monophosphate deaminase
reactant: MODEL1310110009#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
fast: false
kinetic law: MODEL1310110009#

metaR r0926
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
product: MODEL1310110009#
name: Postulated transport reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
reversible: false
type: Reaction
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110009#_065aab28_4cb0_4647_94df_c081a59bd7ca
constant: false
initial amount: NaN
name: VNN3:VNN2:VNN1
type: Species
boundary condition: true
is: SBO:0000297
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55350

metaR FAOXC204C184m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

metaR 3HBCOAHLm
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
product: MODEL1310110009#
reversible: false
reactant: MODEL1310110009#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
kinetic law: MODEL1310110009#
is described by: ECO:0000000
fast: false

metaR C226CRNt
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000000
fast: false
name: C226 transport into the mitochondria
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_d90b93bc_b7c9_43f5_ab7a_0cc1b07365bb
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
name: ACOT2
is: P49753
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:10965

metaR r1381
reversible: true
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
product: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110009#
type: Reaction
is: SBO:0000176

metaR FUCASEe
product: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.51
reactant: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
name: alpha-fucosidase, extracellular

metaR DOLPGT1 Uer
reversible: false
type: Reaction
fast: false
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10359825 NOTES:EC 2.4.1.- NCD
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.1.267
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110009#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_454a7883_9fe6_4a34_838c_14e03b8b1b4f
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: SLC43A1
is: O75387
is encoded by: hsa:8501
constant: false
type: Species
is: SBO:0000252

metaM o2 n
constant: false
is: HMDB01377
boundary condition: false
type: Species
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
name: dioxygen
is: CHEBI:15379
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR r1019
product: MODEL1310110009#
kinetic law: MODEL1310110009#
name: Postulated transport reaction
is described by: ECO:0000000
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
fast: false
type: Reaction
reversible: true
is: SBO:0000185

metaM ac c
is: SBO:0000247
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: acetate
has only substance units: false
is: CHEBI:30089
is: HMDB00042
constant: false

metaM arach c
initial amount: NaN
has only substance units: false
is: HMDB02212
name: arachidate
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:32360
constant: false
initial concentration: 1.0

metaM Asn X Ser Thr r
is: CHEBI:28938
is: C01342
constant: false
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: XH CHARGE: 0
initial amount: NaN
is: HMDB00051
name: protein-linked asparagine residue (N-glycosylation site)
has only substance units: false
initial concentration: 1.0

metaR r0400
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000176
reversible: true
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
product: MODEL1310110009#
fast: false
type: Reaction
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.2.4.4

metaM Rtotalcoa c
has only substance units: false
is: CHEBI:16189
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
name: R total Coenzyme A
is: HMDB01448
type: Species

metaR PIter
reactant: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000212
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
type: Reaction
name: phosphate transport, endoplasmic reticulum
fast: false
kinetic law: MODEL1310110009#
product: MODEL1310110009#

metaR PDX5PO
fast: false
kinetic law: MODEL1310110009#
reversible: true
is version of: http://identifiers.org/ec-code/1.4.3.5
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES:NCD
is: SBO:0000176
product: MODEL1310110009#
is described by: ECO:0000269
modifier: MODEL1310110009#
type: Reaction
name: pyridoxine 5'-phosphate oxidase

metaM pi r
is: C00009
constant: false
boundary condition: false
has only substance units: false
is: HMDB00973
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474

metaM pmtcoa m
initial concentration: 1.0
name: Palmitoyl-CoA (n-C16:0CoA)
is: C00154
is: HMDB01338
is: CHEBI:57379
initial amount: NaN
has only substance units: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
constant: false
is: SBO:0000247
boundary condition: false
type: Species

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaR FAOXC164GC163m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

metaR URIDK2m
is described by: ECO:0000134
fast: false
name: uridylate kinase (dUMP), mitochondrial
is: SBO:0000176
reversible: true
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_1c987245_9afa_4f41_bdd4_368d50618f53
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: _R39999_1_c
boundary condition: true
is encoded by: hsa:R39999
type: Species
has only substance units: false

metaM ksii core2 deg3 l
initial concentration: 1.0
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:12936
has only substance units: false
constant: false
is: HMDB00143
name: keratan sulfate II (core 2-linked), degradation product 3

metaM 4aphdob c
is: HMDB00978
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
constant: false
is: CHEBI:58147
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_a7ec814b_d3b7_4708_b865_398d4280f2be
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI972237
name: _AI972237_1_c
initial amount: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252

metaM dhcholestancoa r
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
initial amount: NaN
is: HMDB02159
type: Species
boundary condition: false
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
has only substance units: false
is: CHEBI:15494
is: SBO:0000247
initial concentration: 1.0

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaM phytcoa c
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB01359
is: CHEBI:57391
boundary condition: false
name: phytanoyl-CoA(4-)
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1

metaM Asn X Ser Thr l
constant: false
notes: FORMULA: XH CHARGE: 0
is: CHEBI:28938
is: HMDB00051
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: C01342
name: protein-linked asparagine residue (N-glycosylation site)
is: SBO:0000247
type: Species
initial amount: NaN

metaR DOLPMT3 Ler
type: Reaction
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.1.260
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
modifier: MODEL1310110009#
product: MODEL1310110009#
reversible: false
kinetic law: MODEL1310110009#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_e77fc0df_8e76_4452_8c1b_9c45e0d34367
is: SBO:0000252
is: Q9NVE7
boundary condition: true
initial amount: NaN
name: PANK4
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:55229
type: Species

metaR r0281
modifier: MODEL1310110009#
reversible: true
type: Reaction
kinetic law: MODEL1310110009#
fast: false
is version of: http://identifiers.org/ec-code/5.3.1.6
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
is described by: ECO:0000000
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
is: SBO:0000176
product: MODEL1310110009#

metaR LGTHL
is described by: ECO:0000269
modifier: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF
kinetic law: MODEL1310110009#
type: Reaction
reversible: false
reactant: MODEL1310110009#
name: lactoylglutathione lyase
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/4.4.1.5

metaR FACOAL2252
product: MODEL1310110009#
name: fatty-acid--CoA ligase
is: SBO:0000176
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
type: Reaction
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110009#_196d6ce7_8b0f_4df2_829a_0c968c3363b8
constant: false
is: P31937
initial concentration: NaN
is encoded by: hsa:11112
name: HIBADH
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaM hexdectecoa x
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: 2,4,7,10-hexadecatetraenoylcoa
is: HMDB02288
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
constant: false

metaM ksii core2 deg4 l
initial concentration: 1.0
constant: false
is: HMDB01354
initial amount: NaN
is: CHEBI:57455
is: SBO:0000247
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 4
type: Species
boundary condition: false
notes: FORMULA: C58H95N5O43SX CHARGE: -1

metaR ACITL
is version of: http://identifiers.org/ec-code/2.3.3.8
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
reversible: false
reactant: MODEL1310110009#
fast: false
product: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000000
kinetic law: MODEL1310110009#
is: SBO:0000176
name: ATP-Citrate lyase
type: Reaction

metaR IDOURtly
reversible: true
product: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
name: iduronate transport into lysososme
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_82391c2b_8d51_43cc_b559_1935980f865c
type: Species
boundary condition: true
is encoded by: hsa:10449
constant: false
is: SBO:0000252
initial amount: NaN
is: P42765
name: ACAA2
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_bbaeae68_712d_4a7f_9a62_9c5a32c414d6
name: DCXR
is: SBO:0000252
is: Q7Z4W1
constant: false
is encoded by: hsa:51181
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true

metaM tcynt m
constant: false
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
name: thiocyanate
initial concentration: 1.0
is: CHEBI:18022
is: HMDB01453
is: SBO:0000247
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755

http://identifiers.org/biomodels.db/MODEL1310110009#_9c037e2d_e51f_4044_9576_584efa189ce9
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AA977580
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
name: _AA977580_1_c

metaR PPItr
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
kinetic law: MODEL1310110009#
name: Diphosphate transporter, endoplasmic reticulum
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110009#

metaR FALDH
type: Reaction
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
reactant: MODEL1310110009#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.1
name: formaldehyde dehydrogenase
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110009#_e44309d3_a26e_4b67_969b_cf78b247d4b4
type: Species
initial concentration: NaN
is: Q8NEM3
is: SBO:0000252
name: SLC16A7
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:9194

metaR NACHEXA20ly
product: MODEL1310110009#
reversible: false
is: SBO:0000176
name: beta-N-acetylhexosaminidase A, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
modifier: MODEL1310110009#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#

metaR r0603
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.12
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110009#
fast: false
product: MODEL1310110009#
reversible: true
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
is: SBO:0000176

metaR GLNALANaEx
fast: false
is: SBO:0000185
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)
reversible: false
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000269
modifier: MODEL1310110009#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_c1c97d8e_d6b5_46c5_826e_c62b9ce17adc
type: Species
is: P54819
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:204
name: AK2
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR FAOXC102x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)x
type: Reaction

metaR EX 2mcit LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Methylcitrate exchange
type: Reaction

metaR FACOAL2251
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110009#
name: fatty-acid--CoA ligase
reactant: MODEL1310110009#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_5a9027fb_e763_4cb6_9a35_5079d8b18626
initial amount: NaN
name: PLCB1
boundary condition: true
is encoded by: hsa:23236
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q9NQ66
type: Species

metaR r1167
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
type: Reaction
is described by: ECO:0000000
name: EC:2.3.1.26
fast: false
reversible: false
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_b464a590_0d9f_4ae2_9b07_23df00d568f0
is: Q6IBB5
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: NDUFA1
is encoded by: hsa:4694
boundary condition: true
constant: false
initial amount: NaN

metaM pail34p hs c
constant: false
initial amount: NaN
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
is: CHEBI:57658
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)

metaM pi m
is: CHEBI:43474
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: SBO:0000247
constant: false
type: Species
has only substance units: false
name: hydrogenphosphate
is: C00009
is: HMDB00973

metaR r0829
reversible: true
product: MODEL1310110009#
fast: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
modifier: MODEL1310110009#
is: SBO:0000185
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.37
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaR ABTti
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110009#
name: L-arabinitol transport via passive diffusion
reactant: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110009#
is: SBO:0000185
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_6053a185_6491_4125_8768_95c1cbda722a
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:230
is: SBO:0000252
name: ALDOC
is: P09972
constant: false
type: Species
boundary condition: true

metaR PAPStg
name: 3'-Phosphoadenylyl sufate Golgi transport
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
reversible: true
fast: false
product: MODEL1310110009#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
reactant: MODEL1310110009#
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_33db778e_d022_404f_ae29_3b6740e82d54
name: CPT1B
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:1375
is: B7Z5T8
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_e6b4db5a_9e7d_42b0_acf2_43fe321707fb
name: ATP5J
is encoded by: hsa:522
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaM hs deg6 l
is: HMDB01352
initial amount: NaN
name: heparan sulfate, degradation product 6
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
type: Species
is: CHEBI:17180

metaM glyc e
is: SBO:0000247
has only substance units: false
is: HMDB00131
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
boundary condition: false
constant: false
name: Glycerol
initial amount: NaN
type: Species
is: C00116
is: CHEBI:17754
initial concentration: 1.0

metaM pi n
is: HMDB00973
is: SBO:0000247
constant: false
is: CHEBI:43474
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN
name: hydrogenphosphate

metaR PRASCS
is: SBO:0000176
type: Reaction
product: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/6.3.2.6
reactant: MODEL1310110009#
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
modifier: MODEL1310110009#
is described by: ECO:0000269
reversible: true

metaR GAPD
modifier: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
name: glyceraldehyde-3-phosphate dehydrogenase
is: SBO:0000176
product: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.2.1.12
reversible: true
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.

metaM ump g
is: CHEBI:57865
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: UMP(2-)
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288

metaR MG1er
is: SBO:0000176
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
kinetic law: MODEL1310110009#
reversible: false
reactant: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110009#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.106
product: MODEL1310110009#

metaM ksi deg11 l
initial concentration: 1.0
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
is: CHEBI:12936
has only substance units: false
name: keratan sulfate I, degradation product 11
constant: false
is: HMDB00143
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_4b9ae108_37bf_4650_9993_42f03da993dc
constant: false
boundary condition: true
is: Q308M7
name: ENPP3
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5169
type: Species
is: SBO:0000252
initial amount: NaN

metaM o2 r
boundary condition: false
constant: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007
is: SBO:0000247
name: O2
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB01377
is: CHEBI:15379

metaR S6T10g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
is: SBO:0000176
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110009#
modifier: MODEL1310110009#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110009#_083dc317_0bbf_429a_8c0b_dc98d93c61ca
boundary condition: true
name: UAP1L1
is: Q3KQV9
is encoded by: hsa:91373
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN

metaM pro D c
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: D-proline
is: HMDB03411
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:16313
type: Species

metaM 3hexdtetcoa x
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
name: 3,7,10,13-hexadecatetraenoylcoa
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: HMDB02288
initial concentration: 1.0
constant: false
type: Species

metaM vacccoa c
initial concentration: 1.0
initial amount: NaN
name: vaccenyl coenzyme A
constant: false
is: http://identifiers.org/pubchem.compound/9543677
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
is: HMDB06521
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species

metaR FAOXC102C101m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_cba5847e_c05b_4606_b80c_5e27a4b85412
is encoded by: hsa:AI191472
constant: false
boundary condition: true
name: _AI191472_1_c
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR r0403
kinetic law: MODEL1310110009#
reversible: true
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
is: SBO:0000176
modifier: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.2.4.4
product: MODEL1310110009#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:

metaM cs b deg2 l
constant: false
notes: FORMULA: C37H54NO41S3 CHARGE: -5
initial concentration: 1.0
has only substance units: false
is: CHEBI:57455
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB01354

metaR CEPTE
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.2
product: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (10390.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: ethanolamine phosphotransferase
reactant: MODEL1310110009#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110009#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_cbdba777_324e_4c7a_afeb_1226cde09297
has only substance units: false
constant: false
boundary condition: true
is: P19440
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:2678
name: GGT1
is: SBO:0000252

metaM 2mb2coa c
type: Species
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1
is: HMDB02054
initial amount: NaN
constant: false
name: 2-methylcrotonoyl-CoA(4-)
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM pmtcoa r
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
name: Palmitoyl-CoA (n-C16:0CoA)
is: C00154
is: SBO:0000247
is: HMDB01338
type: Species
is: CHEBI:3454

metaM nadp c
is: C00006
constant: false
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate
is: CHEBI:58349
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: HMDB00217
has only substance units: false
initial amount: NaN

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaM acmana r
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
is: CHEBI:17122
boundary condition: false
name: N-acetyl-D-mannosamine
has only substance units: false
is: HMDB01129
is: SBO:0000247
type: Species

metaR r1585
product: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000

metaR FAOXC15NADx
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid alpha oxidation(2-Hydroxyphytanoyl-CoA)(nad)x
type: Reaction

metaR r2116
modifier: MODEL1310110009#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110009#
product: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
is: SBO:0000185

metaM 3mlda e
constant: false
type: Species
name: 3-Methylimidazoleacetic acid
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
is: http://identifiers.org/pubchem.compound/8122
initial concentration: 1.0
is: HMDB02820
is: C05828

metaR DAGK hs
is described by: ECO:0000269
fast: false
modifier: MODEL1310110009#
name: Diacylglycerol phosphate kinase (homo sapiens)
type: Reaction
reactant: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: true
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.1.107

metaM nadp r
initial amount: NaN
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate
is: CHEBI:58349
is: C00006
has only substance units: false
is: HMDB00217

http://identifiers.org/biomodels.db/MODEL1310110009#_8c15d4a9_9f47_42d2_b891_6827577778a4
is: P49327
type: Species
initial concentration: NaN
constant: false
name: FASN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2194
boundary condition: true
initial amount: NaN

metaR RE2666C
type: Reaction
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:
is: SBO:0000176
name: RE2666
product: MODEL1310110009#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_91e6aa39_0c9b_4a87_8f1d_7eacd8308a03
initial concentration: NaN
constant: false
is encoded by: hsa:1103
is: SBO:0000252
initial amount: NaN
name: CHAT
is: P28329
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_e6bb185c_687c_4558_b3d7_c03c498d3c7e
has only substance units: false
is: SBO:0000252
name: TPI1P2
initial amount: NaN
is encoded by: hsa:286016
boundary condition: true
type: Species
initial concentration: NaN
constant: false

metaM cs a deg1 l
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
is: HMDB01354
initial concentration: 1.0
is: CHEBI:57455
initial amount: NaN
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
type: Species

metaR r1584
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110009#
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185

metaR r2117
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110009#
product: MODEL1310110009#
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110009#_bff68ec0_c68b_4ec6_8057_10c220cea7f9
is: P05062
initial concentration: NaN
has only substance units: false
name: ALDOB
constant: false
initial amount: NaN
is encoded by: hsa:229
type: Species
is: SBO:0000252
boundary condition: true

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_6aa96745_2e01_4888_bd9e_8ad3a4692ced
is: Q16853
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
name: AOC3
constant: false
is: SBO:0000252
is encoded by: hsa:8639

metaM glyc c
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: C00116
constant: false
is: CHEBI:17754
initial amount: NaN
type: Species
is: SBO:0000247
name: Glycerol
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00131

http://identifiers.org/biomodels.db/MODEL1310110009#_59c21e33_861c_49df_9d96_39097c97c697
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
name: PRPS1L1
has only substance units: false
is encoded by: hsa:221823
initial concentration: NaN
constant: false

metaM urcan c
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: C00785
type: Species
initial concentration: 1.0
is: CHEBI:17771
name: Urocanate
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
has only substance units: false
is: HMDB00301
constant: false

metaM 2mb2coa m
initial amount: NaN
is: SBO:0000247
is: CHEBI:57337
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
name: 2-methylcrotonoyl-CoA(4-)
initial concentration: 1.0
is: HMDB02054
type: Species
constant: false
has only substance units: false
boundary condition: false

metaM CE2433 m
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
constant: false
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
is: CHEBI:57795
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_baea80ba_2c00_4cf2_a47a_9f75787013ae
is encoded by: hsa:8622
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
name: PDE8B
boundary condition: true
is: O95263

http://identifiers.org/biomodels.db/MODEL1310110009#_b3e4f73b_bd49_43d5_ba03_1569b289b5ee
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:9091
boundary condition: true
name: PIGQ
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q9BRB3

http://identifiers.org/biomodels.db/MODEL1310110009#_443fa821_838a_4c43_bc5e_cb2a7b1e60bb
is: SBO:0000252
boundary condition: true
is encoded by: hsa:48
constant: false
name: ACO1
initial amount: NaN
is: P21399
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_340ba527_f662_439b_bfe7_f78ae43c94f3
is encoded by: hsa:2820
has only substance units: false
name: GPD2
constant: false
initial amount: NaN
is: P43304
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN

metaR FATP8t
is version of: http://identifiers.org/ec-code/6.2.1.7
modifier: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
name: fatty acid electroneutral transport
kinetic law: MODEL1310110009#
reversible: true
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR r1583
type: Reaction
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR 2OXOADOXm
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
reactant: MODEL1310110009#
is described by: ECO:0000304
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.2.4.2
fast: false
is: SBO:0000176
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
type: Reaction
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.61
product: MODEL1310110009#
reversible: false

metaM L2aadp m
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
boundary condition: false
type: Species
is: CHEBI:58672
constant: false
initial concentration: 1.0
name: L-2-aminoadipate(1-)
is: HMDB00510
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR r2114
is: SBO:0000185
modifier: MODEL1310110009#
reversible: true
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110009#
product: MODEL1310110009#
type: Reaction

metaR PCHOLP hs
reversible: false
kinetic law: MODEL1310110009#
fast: false
name: choline phosphatase
modifier: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.4
type: Reaction
reactant: MODEL1310110009#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110009#_fbbf3c26_a97e_443f_bf63_255e81523db7
constant: false
initial concentration: NaN
is encoded by: hsa:116369
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q96RN1
has only substance units: false
name: SLC26A8

metaR AKGMALtm
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
fast: false
is: SBO:0000185
is described by: ECO:0000269
name: alpha-ketoglutarate/malate transporter
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110009#_d8a55e74_9fbd_4479_b2bc_5abc4e82399f
name: _LOC647190_1_c
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:LOC647190
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false

metaR ACACt2
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110009#
product: MODEL1310110009#
reversible: true
fast: false
kinetic law: MODEL1310110009#
name: acetoacetate transport via proton symport
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
modifier: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_23b5f3e1_58b7_416e_9784_5a8361033b69
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:641649
initial concentration: NaN
name: TMEM91
is: SBO:0000252
constant: false
is: C9JZ62

http://identifiers.org/biomodels.db/MODEL1310110009#_9b1c9af9_5c2f_4ff5_9ffa_e040cc564089
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:NOS2A
name: _NOS2A_1_c

metaR FUCtly
type: Reaction
product: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
name: L-fucose efflux from lysosome
is: SBO:0000185
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
reactant: MODEL1310110009#

metaR FAOXC101x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)x
type: Reaction

metaM ksi deg19 l
constant: false
name: keratan sulfate I, degradation product 19
is: CHEBI:57455
has only substance units: false
is: HMDB01354
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C146H236N10O124S6 CHARGE: -6

metaM f1p c
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB01076
has only substance units: false
is: C01094
is: CHEBI:18105
is: SBO:0000247
name: D-Fructose 1-phosphate
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00662 EHMN_ABBREVIATION: C01094

metaM prpp c
initial concentration: 1.0
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
type: Species
is: HMDB00280
is: CHEBI:58017
has only substance units: false
constant: false
name: 5-Phospho-alpha-D-ribose 1-diphosphate
initial amount: NaN
is: SBO:0000247
is: C00119
boundary condition: false

metaR r2115
reversible: true
kinetic law: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110009#
modifier: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

metaR PNTK
reversible: false
is: SBO:0000176
reactant: MODEL1310110009#
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.1.33
type: Reaction
kinetic law: MODEL1310110009#
name: pantothenate kinase
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110009#_63b0c5f9_318f_44c4_a9c4_1cc093cb5ba9
type: Species
is: O95497
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8876
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: VNN1

metaR BHBt
reversible: true
fast: false
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
is: SBO:0000185
name: (R)-3-Hydroxybutanoate transport via H+ symport
is described by: ECO:0000000
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_791b8dc5_5779_44ad_9b3a_b73732100163
has part: P18859
constant: false
is encoded by: hsa:522
initial amount: NaN
has part: O75947
has part: P24539
is encoded by: hsa:515
boundary condition: true
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
is encoded by: hsa:518
is: SBO:0000297
type: Species
is encoded by: hsa:10476

metaR DECCRNe
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydecanoyl carnitine into extra cellular space
type: Reaction

metaM ptth c
is: CHEBI:16753
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
name: pantetheine
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB03426

http://identifiers.org/biomodels.db/MODEL1310110009#_bd702661_1efc_4c22_a667_282f5bc90ea7
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: NDUFS5
constant: false
type: Species
is: Q6IBA0
is encoded by: hsa:4725
boundary condition: true

metaM nadp m
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: C00006
type: Species
name: Nicotinamide adenine dinucleotide phosphate
initial concentration: 1.0
initial amount: NaN
is: HMDB00217
boundary condition: false
is: CHEBI:58349
is: SBO:0000247
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_98e31eb7_b8cc_4894_9ed0_783b035992d8
name: PANK4
initial concentration: NaN
is encoded by: hsa:55229
is: Q9NVE7
constant: false
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR DNDPt15m
modifier: MODEL1310110009#
name: dUDP transport via dGDP antiport
reversible: false
reactant: MODEL1310110009#
is described by: ECO:0000269
product: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR r2112
is: SBO:0000185
modifier: MODEL1310110009#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110009#
product: MODEL1310110009#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction

metaR FAOXC12DCx
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanedioyl carnitine
type: Reaction

metaR B MANNASEly
kinetic law: MODEL1310110009#
product: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.25
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
fast: false
name: beta-mannosidase, lysosomal

metaR FAOXC102C101x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:1)x
type: Reaction

metaM orot c
constant: false
has only substance units: false
name: Orotate
is: HMDB00226
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:30839
is: C00295

metaR CRVNCtr
name: fatty acid transport via diffusion
is described by: ECO:0000000
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
reversible: true
kinetic law: MODEL1310110009#
product: MODEL1310110009#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110009#_80c69e26_d03e_4b95_bf49_13b35bc67645
initial amount: NaN
constant: false
name: B4GALT2
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8704
initial concentration: NaN

metaR HAtly
product: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: hyaluronan transport, extracellular to lysosome
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110009#
is: SBO:0000185
reversible: false

metaR r1581
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110009#
product: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM ksi pre34 g
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
type: Species
is: SBO:0000247
is: C00130
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 34
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:58053
is: HMDB00175
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_849a75c0_2a0f_418c_9c64_910bc89271f4
is: P51828
initial concentration: NaN
type: Species
is encoded by: hsa:113
is: SBO:0000252
name: ADCY7
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false

metaM ump r
name: UMP
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
is: HMDB00288
is: CHEBI:57865
type: Species
constant: false
boundary condition: false
is: SBO:0000247

metaR r0821
reversible: true
reactant: MODEL1310110009#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
kinetic law: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110009#_3d71a006_bf6e_4617_8a5b_0fa6f893a3be
name: PDE4D
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5144
constant: false
type: Species
is: Q08499
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_f6a278f3_901f_44e3_bb0e_6d7527c18d9a
is encoded by: hsa:100
constant: false
type: Species
boundary condition: true
is: P00813
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: ADA

metaR r2113
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

metaR r1384
fast: false
kinetic law: MODEL1310110009#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
reversible: true
reactant: MODEL1310110009#
name: Guanosine aminohydrolase EC:3.5.4.15
is described by: ECO:0000000
product: MODEL1310110009#

metaM 5mta c
initial amount: NaN
type: Species
name: 5-Methylthioadenosine
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
has only substance units: false
is: C00170
is: SBO:0000247
is: HMDB01173
constant: false
is: CHEBI:17509
initial concentration: 1.0
boundary condition: false

metaR PFK
kinetic law: MODEL1310110009#
name: phosphofructokinase
fast: false
notes: GENE_ASSOCIATION: (5214.1) or (5211.2) or (5214.1 and 5211.1) or (5214.1 and 5213.1) or (5213.1) or (5214.1 and 5211.2) or (5211.1) or (5211.1 and 5213.1) or (5213.1 and 5211.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
reversible: false
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.1.11

metaM HC02205 c
initial amount: NaN
name: prostaglandin-b2
has only substance units: false
is: SBO:0000247
is: CHEBI:28099
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
constant: false
boundary condition: false
type: Species

metaM dectricoa x
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: 2,4,7-decatrienoylcoa
notes: FORMULA: C31H44N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110009#_dd2e8333_2ba1_4282_8bf5_3d5769e27a7c
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: P27707
has only substance units: false
name: DCK
constant: false
type: Species
boundary condition: true
is encoded by: hsa:1633

metaM prpp e
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:58017
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
is: HMDB00280
boundary condition: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
has only substance units: false

metaR r1580
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110009#
product: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR ADK1m
reactant: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
is described by: ECO:0000269
name: adenylate kinase, mitochondrial
is: SBO:0000176
kinetic law: MODEL1310110009#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
product: MODEL1310110009#

metaR PAIL45P HStn
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
product: MODEL1310110009#
is: SBO:0000185

metaR r0822
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110009#
is described by: ECO:0000000
kinetic law: MODEL1310110009#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110009#_891c374e_5082_435f_ad15_6e853d8dd00d
constant: false
type: Species
is encoded by: hsa:23556
name: PIGN
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_6ed7e71b_734d_4c14_83a7_5112b0125898
is: SBO:0000252
initial amount: NaN
name: _AA081045_1_c
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:AA081045
boundary condition: true

metaR ARSA
product: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
type: Reaction
name: Arylsulfatase A
is version of: http://identifiers.org/ec-code/3.1.6.8
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ

metaR CERT2rt
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110009#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110009#
reversible: true
name: ceramide transport protein
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is described by: ECO:0000000
fast: false
product: MODEL1310110009#
reactant: MODEL1310110009#

metaM orot e
is: HMDB00226
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
name: orotate
is: CHEBI:30839
boundary condition: false
constant: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295

metaR r2110
product: MODEL1310110009#
type: Reaction
fast: false
kinetic law: MODEL1310110009#
is: SBO:0000185
modifier: MODEL1310110009#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM 3mlda c
boundary condition: false
has only substance units: false
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/8122
initial amount: NaN
is: HMDB02820
is: C05828
name: 3-Methylimidazoleacetic acid

metaR PPItm
is described by: ECO:0000134
reversible: true
is: SBO:0000185
fast: false
name: diphopshate transporter, mitochondrial
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
type: Reaction
product: MODEL1310110009#

metaR PA HStn
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: phosphatidate transport, nuclear
reactant: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110009#
product: MODEL1310110009#
fast: false

metaR r0287
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is: SBO:0000176
reactant: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110009#
reversible: false
fast: false
kinetic law: MODEL1310110009#
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110009#_1c437294_36b3_464d_bfbf_edbb8c55ffa5
constant: false
name: SLC12A5
is: SBO:0000252
is encoded by: hsa:57468
type: Species
initial amount: NaN
is: Q9H2X9
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_f276f47f_834c_4031_92dc_ddabc794557b
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: DBH
initial concentration: NaN
is encoded by: hsa:1621
type: Species
has only substance units: false
is: P09172

http://identifiers.org/biomodels.db/MODEL1310110009#_29aff82e_6854_4332_a6a6_8d6770bce5c7
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:2678
boundary condition: true
is: P19440
is: SBO:0000252
name: GGT1

metaM hexdiac c
is: HMDB00672
initial concentration: 1.0
constant: false
name: hexadecanediocacid
notes: FORMULA: C16H28O4 CHARGE: -2
type: Species
is: C08260
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false

metaM HC01361 e
is: CHEBI:17001
boundary condition: false
type: Species
has only substance units: false
name: Dihydroneopterin
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H13N5O4 CHARGE: 0 INCHI: InChI=1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1 EHMN_ABBREVIATION: C04874
constant: false

metaR EX gum LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for guar gums
type: Reaction

metaR RE1534M
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110009#
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110009#
name: RE1534
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110009#
type: Reaction

metaR r2111
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110009#
fast: false
is: SBO:0000185
product: MODEL1310110009#
type: Reaction
modifier: MODEL1310110009#

metaM 5mta e
constant: false
initial amount: NaN
notes: FORMULA: C11H15N5O3S CHARGE: 0
has only substance units: false
name: 5-Methylthioadenosine
boundary condition: false
is: C00170
type: Species
is: HMDB01173
is: CHEBI:17509
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_e2b6d183_9bf3_495b_88d9_fc08c8ef2134
name: ALDH1A3
is: SBO:0000252
type: Species
initial amount: NaN
is: P47895
has only substance units: false
initial concentration: NaN
is encoded by: hsa:220
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_8a5e5610_95db_4f42_bf38_754000f73513
has only substance units: false
is: P16278
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:2720
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: GLB1

metaR RE2659R
is described by: ECO:0000000
is: SBO:0000176
reversible: true
name: RE2659
reactant: MODEL1310110009#
product: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_d7a81483_181a_4e0d_8787_3889ec0db699
is encoded by: hsa:7296
has only substance units: false
name: TXNRD1
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
initial concentration: NaN

metaM dump c
initial concentration: 1.0
is: C00365
is: HMDB01409
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:246422
boundary condition: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
name: dUMP
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_b6800f4d_9b84_4956_8802_28e9380172e0
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: O75355
name: ENTPD3
constant: false
is encoded by: hsa:956
type: Species
boundary condition: true
is: SBO:0000252

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_60f41837_af08_4fe2_acfd_f55041651df6
initial amount: NaN
is: SBO:0000252
name: RDH16
constant: false
is encoded by: hsa:8608
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: O75452

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

metaM dectricoa m
initial amount: NaN
has only substance units: false
name: 2,4,7-decatrienoylcoa
constant: false
is: SBO:0000247
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
initial concentration: 1.0
type: Species

metaM e4hglu m
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: erythro-4-hydroxy-L-glutamate(1-)
is: CHEBI:6331
is: HMDB02273
has only substance units: false
constant: false
type: Species
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947

metaM acmana c
type: Species
initial concentration: 1.0
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
name: N-acetyl-D-mannosamine
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB01129
is: CHEBI:17122

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_49271863_cb88_4ef4_93f8_a2ae0b0584c7
name: _AI935189_1_m
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI935189
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_98eec1b6_f430_4800_b8cc_7e2677945ca6
has only substance units: false
name: PDE1A
is: P54750
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:5136

http://identifiers.org/biomodels.db/MODEL1310110009#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

metaR UAGALDP
name: UDP-N-acetylgalactosamine diphosphorylase
reactant: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110009#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110009#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_da96450e_4df2_400c_a39a_4f801f2db696
is: SBO:0000252
name: _AI926493_1_c
initial amount: NaN
type: Species
is encoded by: hsa:AI926493
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true

metaR r2506
name: Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110009#
is: SBO:0000185
product: MODEL1310110009#
reversible: true
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false

metaM HC02023 r
initial concentration: 1.0
initial amount: NaN
name: Cholesterol-ester-ol
type: Species
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
constant: false
is: CHEBI:46898
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM m2emgacpail hs r
is: CHEBI:24636
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
is: SBO:0000247
is: C00080
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0

metaM 5adtststerone e
constant: false
is: HMDB02961
initial concentration: 1.0
is: CHEBI:16330
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
has only substance units: false
type: Species
boundary condition: false
name: 17beta-hydroxy-5alpha-androstan-3-one
is: SBO:0000247
initial amount: NaN

metaR SPHS1Ptr
kinetic law: MODEL1310110009#
reversible: true
name: sphingosine-1-phosphate transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
product: MODEL1310110009#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110009#

metaM dhap x
is: SBO:0000247
is: C00111
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/3411
has only substance units: false
is: HMDB01473
initial concentration: 1.0
initial amount: NaN
name: Dihydroxyacetone phosphate
is: CHEBI:57642
boundary condition: false

metaR GLUPROASCT1
reactant: MODEL1310110009#
reversible: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110009#
is described by: ECO:0000134
product: MODEL1310110009#
name: glutamate intake by system ASCT-1 transporter
modifier: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.

metaR C12DCACT
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of Dodecanedioic acid
type: Reaction

metaR SUCOAS1m
type: Reaction
reversible: true
modifier: MODEL1310110009#
fast: false
is: SBO:0000176
name: Succinate--CoA ligase (GDP-forming)
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
is described by: ECO:0000000
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/6.2.1.4

metaM ptth m
type: Species
is: SBO:0000247
is: HMDB03426
constant: false
is: CHEBI:16753
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: pantetheine
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
initial amount: NaN

metaR SIAASEly
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110009#
is: SBO:0000176
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction

metaM phe L e
is: CHEBI:17295
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: HMDB00159
is: SBO:0000247
name: L-phenylalanine
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_b103cb94_69e4_4a16_8b92_3cce55d10ebe
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
name: _D87002_1_e
is encoded by: hsa:D87002

http://identifiers.org/biomodels.db/MODEL1310110009#_57cf714a_e080_4acf_9a73_0ea7306bcd8f
name: SLC13A1
has only substance units: false
is encoded by: hsa:6561
boundary condition: true
initial concentration: NaN
is: Q9BZW2
constant: false
type: Species
initial amount: NaN
is: SBO:0000252

metaR PYAM5POr
kinetic law: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:NCD IT
is version of: http://identifiers.org/ec-code/1.4.3.5
fast: false
reactant: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
is described by: ECO:0000269
reversible: true
name: pyridoxamine 5'-phosphate oxidase
is: SBO:0000176

metaM acmana e
is: SBO:0000247
name: N-acetyl-D-mannosamine
has only substance units: false
initial amount: NaN
is: CHEBI:17122
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
boundary condition: false
type: Species
is: HMDB01129
initial concentration: 1.0
constant: false

metaM vacccoa m
name: vaccenyl coenzyme A
boundary condition: false
is: HMDB06521
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
is: http://identifiers.org/pubchem.compound/9543677
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0

metaR DOLP Uter
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
product: MODEL1310110009#
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
name: dolichol phosphate flippase (uterus)

metaR EX caro LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Carotene exchange
type: Reaction

metaR GTMLTe
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES:NCD SAB e see Disussion section of PMID 15469854
is described by: ECO:0000269
reactant: MODEL1310110009#
reversible: false
product: MODEL1310110009#
type: Reaction
name: g-glutamyltransferase (e)
modifier: MODEL1310110009#
is: SBO:0000185
fast: false
is version of: http://identifiers.org/ec-code/2.3.2.2

metaM nadp x
name: Nicotinamide adenine dinucleotide phosphate
constant: false
is: C00006
is: CHEBI:58349
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00217

metaM pi c
constant: false
name: hydrogenphosphate
type: Species
is: CHEBI:43474
has only substance units: false
is: SBO:0000247
is: C00009
notes: FORMULA: HO4P CHARGE: -2
is: HMDB00973
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR GLCNACASE2ly
is described by: ECO:0000000
modifier: MODEL1310110009#
fast: false
name: alpha-N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.50
is: SBO:0000176
kinetic law: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#

metaR G6Pter
is described by: ECO:0000269
fast: false
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: true
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
type: Reaction
modifier: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD

metaR r0714
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
is: SBO:0000176
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: false
reactant: MODEL1310110009#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_9e791c34_0063_41b9_86fe_a1449a7cf274
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: Q548A7
boundary condition: true
name: SLC26A6
is encoded by: hsa:65010
is: SBO:0000252

metaR r2508
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
reactant: MODEL1310110009#
is: SBO:0000185
type: Reaction
product: MODEL1310110009#
reversible: true
fast: false
is described by: ECO:0000000

metaR r2001
product: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110009#
modifier: MODEL1310110009#

metaM 5adtststerone c
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
has only substance units: false
is: HMDB02961
is: CHEBI:16330
boundary condition: false
name: 17beta-hydroxy-5alpha-androstan-3-one
type: Species

metaM 11 cis retfa e
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
is: SBO:0000247
constant: false
boundary condition: false
type: Species
is: HMDB00224
has only substance units: false
initial amount: NaN
is: CHEBI:58190
name: fatty acid 11-cis-retinol
initial concentration: 1.0

metaM 1pyr5c m
name: 1-Pyrroline-5-carboxylate
is: CHEBI:15893
boundary condition: false
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
is: C03912
initial amount: NaN
is: HMDB01301

http://identifiers.org/biomodels.db/MODEL1310110009#_b7df458e_c14f_4d56_af1a_a55651537e39
constant: false
is encoded by: hsa:1384
type: Species
initial concentration: NaN
name: CRAT
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR RE1523M
is described by: ECO:0000000
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
reversible: true
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110009#
name: RE1523
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM 5tedtricoa m
name: 5,8,11-tetradecatrienoylcoa
has only substance units: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB02288
initial amount: NaN
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_36fa124b_545d_42be_bada_7a71e7a39edf
constant: false
is: SBO:0000252
name: FOLR1
is encoded by: hsa:2348
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN

metaR DALAt2r
modifier: MODEL1310110009#
type: Reaction
is: SBO:0000185
name: D-alanine transport via proton symport
kinetic law: MODEL1310110009#
is described by: ECO:0000304
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
reversible: true
reactant: MODEL1310110009#
product: MODEL1310110009#

metaM dopa c
name: dopaminium(1+)
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:59905
initial amount: NaN
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
type: Species
is: HMDB00073
initial concentration: 1.0
has only substance units: false

metaR r0715
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
modifier: MODEL1310110009#
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is version of: http://identifiers.org/ec-code/6.3.2.5
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
product: MODEL1310110009#
reversible: false
is: SBO:0000176
fast: false

metaM adpcoa x
name: adipoylcoa
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB04047
constant: false
is: C14143
has only substance units: false
type: Species
notes: FORMULA: C27H39N7O19P3S CHARGE: -5

metaR r2509
is described by: ECO:0000000
fast: false
product: MODEL1310110009#
type: Reaction
reversible: true
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
name: Utilized transport

metaM phe L c
initial amount: NaN
is: CHEBI:17295
is: HMDB00159
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
name: L-phenylalanine
constant: false

metaM HC02205 e
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: prostaglandin-b2
is: CHEBI:28099
constant: false
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
initial concentration: 1.0
has only substance units: false

metaR OMPDC
is described by: ECO:0000269
product: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
modifier: MODEL1310110009#
reversible: false
is: SBO:0000176
name: orotidine-5'-phosphate decarboxylase
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.2.10
type: Reaction
fast: false

metaM arg L e
is: CHEBI:32682
boundary condition: false
constant: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00517
is: SBO:0000247
name: L-argininium(1+)

http://identifiers.org/biomodels.db/MODEL1310110009#_f7b788f6_6047_4c1a_b4b0_49131f0dccd5
type: Species
is: SBO:0000252
boundary condition: true
is: Q96NR8
has only substance units: false
is encoded by: hsa:145226
initial amount: NaN
name: RDH12
initial concentration: NaN
constant: false

metaR PROSTGD2t
product: MODEL1310110009#
fast: false
name: prostaglandin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
reversible: true
reactant: MODEL1310110009#

metaR DNDPt26m
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000269
name: dCDP transport via dUDP antiport
product: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false

metaM octe5coa m
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
constant: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: 5-octenoylcoa

metaM phyt x
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
is: SBO:0000247
type: Species
constant: false
boundary condition: false
is: HMDB00801
initial amount: NaN
has only substance units: false
name: phytanate
is: CHEBI:37257
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_613c1dec_2987_4216_9811_499b819205f5
is: SBO:0000252
has only substance units: false
is: Q15181
type: Species
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
name: PPA1
is encoded by: hsa:5464

http://identifiers.org/biomodels.db/MODEL1310110009#_24fc590b_a644_4e5a_af98_6b3082878196
constant: false
has only substance units: false
boundary condition: true
name: _AA502753_1_m
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:AA502753
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_a478f38c_7c6f_49d2_a69d_e41377987aa4
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: P15954
constant: false
is encoded by: hsa:1350
has only substance units: false
name: COX7C

metaR ACP1 FMN
name: acid phosphatase (FMN)
fast: false
notes: GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:8522318 NOTES:INVALID ECO TERM: IFH
reactant: MODEL1310110009#
product: MODEL1310110009#
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.1.3.2
is described by: ECO:0000254
kinetic law: MODEL1310110009#
is: SBO:0000176
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110009#_2435270d_81ef_4d38_a39a_31d6879038fd
is encoded by: hsa:5728
boundary condition: true
initial concentration: NaN
is: F6KD01
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: PTEN

metaM pac c
is: SBO:0000247
has only substance units: false
type: Species
constant: false
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
is: CHEBI:18401
is: HMDB00209
boundary condition: false
initial amount: NaN
name: phenylacetate
initial concentration: 1.0

metaR r1589
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110009#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110009#
product: MODEL1310110009#

metaM dump n
type: Species
constant: false
is: HMDB01409
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: dUMP(2-)
has only substance units: false
is: CHEBI:246422
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial concentration: 1.0

metaR EX ksii core4 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 4-linked) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_88f2a715_76d9_4131_91c2_8335e217aae7
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:275
is: P48728
initial concentration: NaN
initial amount: NaN
name: AMT

metaR AG13T11g
product: MODEL1310110009#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_8b6285dd_8e73_4e18_9597_633344eb176e
has only substance units: false
is: P48201
name: ATP5G3
type: Species
is encoded by: hsa:518
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_ea93b7ae_fad6_4981_b56a_558801289920
constant: false
initial amount: NaN
has only substance units: false
is: B7Z2M9
boundary condition: true
is: SBO:0000252
name: DGKZ
initial concentration: NaN
is encoded by: hsa:8525
type: Species

metaR RE2998M
product: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110009#
name: RE2998
is: SBO:0000176
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110009#_7a2c9123_8fbc_4ad7_8604_00d47352c14d
initial concentration: NaN
is encoded by: hsa:54407
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
constant: false
name: SLC38A2
initial amount: NaN
is: Q96QD8

http://identifiers.org/biomodels.db/MODEL1310110009#_a504ff51_8b1e_49be_b539_4991225c1142
is: SBO:0000252
type: Species
boundary condition: true
constant: false
is encoded by: hsa:51809
name: GALNT7
initial amount: NaN
initial concentration: NaN
is: Q86SF2
has only substance units: false

metaR CYTK9n
modifier: MODEL1310110009#
reversible: true
is described by: ECO:0000269
product: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000176
kinetic law: MODEL1310110009#
type: Reaction
fast: false
name: cytidylate kinase (CMP,dCTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR SPODMx
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.15.1.1
product: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
reversible: false
name: superoxide dismutase, peroxisome
reactant: MODEL1310110009#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176

metaR HPYRR2x
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000304
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.27
reversible: false
is version of: http://identifiers.org/ec-code/1.1.2.4
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (3948.1) or (197257.1) or (3945.1) or (160287.1) or (3945.1 and 3939.1) or (92483.1) or (3939.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:14635115,PMID:5635456 NOTES:NCD
type: Reaction
name: hydroxypyruvate reductase (NADH)

http://identifiers.org/biomodels.db/MODEL1310110009#_ac5c3fb2_5f66_4979_ba45_80cd2ab144aa
name: NDUFB10
boundary condition: true
is: A8K761
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4716

metaM itp n
is: HMDB00189
boundary condition: false
initial concentration: 1.0
is: CHEBI:57614
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
name: ITP(3-)
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR r1588
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110009#
product: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110009#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110009#_1f79966e_a797_466d_9f83_744e008528ed
initial amount: NaN
constant: false
is: SBO:0000252
is: Q5JWV8
boundary condition: true
is encoded by: hsa:2182
initial concentration: NaN
has only substance units: false
name: ACSL4
type: Species

metaM ptdca e
name: pentadecanoate
is: http://identifiers.org/pubchem.compound/22169126
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00826
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)

metaM arg L c
has only substance units: false
initial concentration: 1.0
is: CHEBI:32682
constant: false
initial amount: NaN
is: HMDB00517
is: SBO:0000247
name: L-argininium(1+)
type: Species
boundary condition: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065

metaM dodecanac x
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: Dodecanedioic acid
initial concentration: 1.0
notes: FORMULA: C12H20O4 CHARGE: -2
is: HMDB00623
boundary condition: false
type: Species

metaR sink c101coa LPAREN c RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C101COASINK
type: Reaction

metaM Rtotal3 e
constant: false
is: SBO:0000247
is: HMDB00244
has only substance units: false
name: R total 3 position
is: C00255
is: CHEBI:3554
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: CO2FULLR3 CHARGE: -1
boundary condition: false

metaM dump m
initial concentration: 1.0
is: HMDB01409
initial amount: NaN
type: Species
is: CHEBI:246422
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
name: dUMP(2-)
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365

metaR N4Tg
name: N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus
reactant: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
product: MODEL1310110009#
reversible: false
kinetic law: MODEL1310110009#
fast: false
is: SBO:0000176
is described by: ECO:0000000

metaR C6CRNe
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexanoyl carnitine into the extra cellular fluid
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_68e42b45_f8ae_4de3_9ba1_dda8c9033051
initial amount: NaN
is: P19440
type: Species
name: GGT1
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:2678

http://identifiers.org/biomodels.db/MODEL1310110009#_025ad27b_6b1b_4e79_be1f_ba08ddecee9b
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:W74642
boundary condition: true
name: _W74642_1_c

metaR MG2er
reactant: MODEL1310110009#
is described by: ECO:0000000
kinetic law: MODEL1310110009#
fast: false
product: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_855799cf_2f8f_4e39_b55c_fda7562adc8a
has only substance units: false
boundary condition: true
is encoded by: hsa:52
initial amount: NaN
name: ACP1
type: Species
initial concentration: NaN
constant: false
is: Q59EH3
is: SBO:0000252

metaR NRPPHRSFt
name: norepinephrine sulfate transport (diffusion)
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110009#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
product: MODEL1310110009#

metaR r2118
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110009#
is described by: ECO:0000000
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110009#
type: Reaction
modifier: MODEL1310110009#

metaR r1587
is described by: ECO:0000000
reactant: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
type: Reaction

metaM m1mpdol U c
initial concentration: 1.0
initial amount: NaN
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C1305H2140N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
is: CHEBI:28067
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_d65f2a7e_239c_40c9_a647_faa7db2ef3fd
name: DLD:GCSH:GLDC:AMT
has part: P48728
boundary condition: true
initial amount: NaN
has part: P23434
type: Species
has only substance units: false
is encoded by: hsa:2731
initial concentration: NaN
constant: false
is encoded by: hsa:275
has part: P23378
is encoded by: hsa:2653
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110009#_76d818c9_990b_4b42_8111_598073574b60
has part: Q6NZ59
is encoded by: hsa:522
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000297
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_0444ed09_852d_4022_afac_d8693d4c30f9
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: NDUFA5
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:4698
is: Q16718

metaR r2119
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185
fast: false
product: MODEL1310110009#
type: Reaction
reversible: true
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR AACOAT
reversible: true
is: SBO:0000176
name: Acetoacetyl-CoA:acetate CoA-transferase
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
fast: false
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/6.2.1.16
modifier: MODEL1310110009#
is described by: ECO:0000269
product: MODEL1310110009#
type: Reaction

metaR RE2987X
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE2987
is: SBO:0000176
product: MODEL1310110009#
modifier: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:10970790,PMID:7775433 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000

metaM Rtotal3 c
is: CHEBI:16189
is: SBO:0000247
is: HMDB01448
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: CO2FULLR3 CHARGE: -1
has only substance units: false
constant: false
initial amount: NaN
name: R total 3 position

metaR r1586
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR GUAt
name: Guanine transport
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
fast: false
product: MODEL1310110009#
modifier: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185
reversible: true

metaR r2525
product: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
reactant: MODEL1310110009#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110009#

metaR VLCSp
name: Very-long-chain-fatty-acid-CoA ligase
reversible: false
is described by: ECO:0000269
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000176
reactant: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ

metaR HACD9m
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
kinetic law: MODEL1310110009#
is described by: ECO:0000134
reactant: MODEL1310110009#
modifier: MODEL1310110009#
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
product: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_e638e192_23a3_4770_8826_8eed842e1a6a
name: HYAL3
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8372
is: O43820

metaM ala L m
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: L-alanine
has only substance units: false
is: HMDB00161
constant: false
type: Species
initial amount: NaN
is: CHEBI:16977
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048

http://identifiers.org/biomodels.db/MODEL1310110009#_e3aafd26_a251_4a1a_969e_b6a4174847e4
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:171425
is: SBO:0000252
is: Q8N0X4
initial concentration: NaN
has only substance units: false
name: CLYBL
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_4cf275f3_4ae4_4424_b087_207ef7913c22
constant: false
is encoded by: hsa:79611
type: Species
is: SBO:0000252
name: ACSS3
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q9H6R3

metaM tdcoa x
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: HMDB01521
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:57385
has only substance units: false
is: C02593
name: Tetradecanoyl-CoA (n-C14:0CoA)
boundary condition: false

metaM ptdca c
type: Species
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/22169126
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00826
name: pentadecanoate
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_9f642be9_1ffe_461e_86df_d411ac6371ca
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI971036
type: Species
has only substance units: false
name: _AI971036_1_m
is: SBO:0000252
initial amount: NaN

metaR AG13T10g
product: MODEL1310110009#
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_b467777c_b8b5_4a0d_859e_185a6c6ba459
is: P60891
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
name: PRPS1
is: SBO:0000252
constant: false
is encoded by: hsa:5631
initial concentration: NaN

metaR HDDACBP
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM CE5126 x
initial concentration: 1.0
is: CHEBI:15748
type: Species
has only substance units: false
constant: false
name: (2R)-pristanoyl-CoA
is: HMDB00127
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5126
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_662169f6_fabd_4f12_8322_c550e6e31c96
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:7358
name: UGDH
constant: false
is: O60701
type: Species
has only substance units: false
initial amount: NaN

metaM dhap c
is: SBO:0000247
is: C00111
type: Species
is: HMDB01473
is: CHEBI:57642
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3411
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: Dihydroxyacetone phosphate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_aef9147b_560d_4e8e_889e_c45b9c16d1d6
is: SBO:0000252
name: VNN3
is encoded by: hsa:55350
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR ALACYSNaEx
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
is described by: ECO:0000269
modifier: MODEL1310110009#
is: SBO:0000185
kinetic law: MODEL1310110009#
product: MODEL1310110009#
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)
type: Reaction
reactant: MODEL1310110009#

metaR EX fuc L LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Fucose exchange
type: Reaction

metaM fdp c
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: C00354
initial concentration: 1.0
is: HMDB01058
is: http://identifiers.org/pubchem.compound/3647
name: D-Fructose 1,6-bisphosphate
initial amount: NaN
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
type: Species
is: CHEBI:16905

http://identifiers.org/biomodels.db/MODEL1310110009#_2fc5b425_7d05_4b8e_be43_7bd635efcb62
constant: false
type: Species
has only substance units: false
name: PIGP
is encoded by: hsa:51227
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR KSIt
type: Reaction
kinetic law: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
reversible: false
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110009#
name: keratan sulfate I transport, golgi to extracellular

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_9e89c7ac_0d67_4270_a3d2_e38c05d2cb07
boundary condition: true
type: Species
has only substance units: false
name: NOS3
is encoded by: hsa:4846
constant: false
initial concentration: NaN
is: A0S0A7
is: SBO:0000252
initial amount: NaN

metaM 5forthf c
is: HMDB01534
name: 5-Formiminotetrahydrofolate
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:57456
type: Species
is: C00664
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664

http://identifiers.org/biomodels.db/MODEL1310110009#_be6446bc_11fa_4794_bd4c_9af15d564ba9
is encoded by: hsa:AA081045
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
name: _AA081045_1_m
type: Species
is: SBO:0000252
has only substance units: false

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaR SCPx
fast: false
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.176
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000269
name: peroxisomal thiolase 2
type: Reaction
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
reversible: false
modifier: MODEL1310110009#
is: SBO:0000176

metaM acrn r
is: HMDB00201
type: Species
has only substance units: false
name: O-acetylcarnitine
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: CHEBI:57589
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_d787d1c8_dbb9_45bb_a9a2_cf9722eee607
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
is: Q5QPH3
is encoded by: hsa:55902
name: ACSS2

http://identifiers.org/biomodels.db/MODEL1310110009#_ecc638cd_7ca0_4dac_960b_3fd579085f7f
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: _AL525798_1_c
has only substance units: false
is encoded by: hsa:AL525798
is: SBO:0000252
constant: false
type: Species

metaR LINOFATPtc
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_304c8a8c_4981_4ff8_aa71_07205fbe1e0c
has only substance units: false
is encoded by: hsa:57379
name: AICDA
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is: Q546Y9
initial amount: NaN

metaR EX c10crn
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decanoyl carnitine
type: Reaction

metaM 5tedtricoa x
is: HMDB02288
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
name: 5,8,11-tetradecatrienoylcoa

metaR PPNCL3
reactant: MODEL1310110009#
name: phosphopantothenate-cysteine ligase
is version of: http://identifiers.org/ec-code/6.3.2.5
type: Reaction
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
fast: false
product: MODEL1310110009#
modifier: MODEL1310110009#

metaM HC01007 x
boundary condition: false
name: L-Octanoylcarnitine
notes: FORMULA: C15H29NO4 CHARGE: 0 INCHI: InChI=1S/C15H29NO4/c1-5-6-7-8-9-10-15(19)20-13(11-14(17)18)12-16(2,3)4/h13H,5-12H2,1-4H3/t13-/m0/s1 EHMN_ABBREVIATION: C02838
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:18102

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

metaR SERTHRNaEx
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110009#
name: L-serine/L-threonine Na-dependent exchange (Ser-L in)
modifier: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000185
reactant: MODEL1310110009#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110009#_7c57fff7_30ea_4697_accd_d15d90bb1c8c
type: Species
is encoded by: hsa:3033
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q16836
name: HADH

http://identifiers.org/biomodels.db/MODEL1310110009#_dcf1448d_2ead_4ac2_8482_030d80c22a80
constant: false
is: P27144
name: AK4
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:205
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_82f87bd7_ac62_4466_8988_50ecc22c776c
is encoded by: hsa:5298
initial concentration: NaN
is: Q9UBF8
boundary condition: true
has only substance units: false
name: PI4KB
type: Species
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_4a178298_132d_417c_9b3c_4f543671cefd
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q53G02
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1603
name: DAD1
type: Species
constant: false

metaR r0707
is version of: http://identifiers.org/ec-code/2.3.1.168
kinetic law: MODEL1310110009#
reversible: true
product: MODEL1310110009#
name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate phosphohydrolase (alkaline optimum) Folate biosynthesis EC:3.1.3.1
is described by: ECO:0000000
fast: false
reactant: MODEL1310110009#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110009#_5a745799_3059_487f_8b18_249c210779d5
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is: B3KVI7
initial concentration: NaN
is encoded by: hsa:3712
initial amount: NaN
name: IVD

metaR r2521
reversible: true
fast: false
name: Utilized transport
product: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
reactant: MODEL1310110009#
is described by: ECO:0000000
kinetic law: MODEL1310110009#
is: SBO:0000185

metaM acrn x
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: SBO:0000247
is: CHEBI:57589
name: O-acetylcarnitine
type: Species
is: HMDB00201
has only substance units: false
initial amount: NaN

metaR RE1525M
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: RE1525
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
kinetic law: MODEL1310110009#

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_16d4488c_ac94_4a79_a2db_7dcb43ba82fc
name: ITPKC
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:80271
is: Q96DU7
type: Species

metaR CYTK10n
modifier: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,dGTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000269

metaM 3octpencoa m
has only substance units: false
is: SBO:0000247
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280355
type: Species
constant: false
initial concentration: 1.0
name: 3,6,9,12,15-octadecapentenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110009#_3879f7cc_8ea0_4cbb_9c2c_1b7648b05561
is: Q67FW5
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: B3GNTL1
is encoded by: hsa:146712
boundary condition: true

metaR r0706
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
reactant: MODEL1310110009#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.3.99.10
reversible: false
fast: false
product: MODEL1310110009#
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6

metaR r2520
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110009#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110009#
reversible: true
product: MODEL1310110009#

metaM CE2838 e
initial amount: NaN
is: SBO:0000247
is: C01936
is: http://identifiers.org/pubchem.compound/5041
type: Species
initial concentration: 1.0
name: maltononaose
constant: false
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_a5dee0d6_60c7_45de_9a70_6fff8ea3fead
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:64080
is: Q9H477
name: RBKS
type: Species
has only substance units: false
initial amount: NaN

metaM fmn c
type: Species
is: C00061
boundary condition: false
initial concentration: 1.0
is: CHEBI:58210
name: FMN
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
has only substance units: false
initial amount: NaN
constant: false
is: HMDB01520
is: SBO:0000247

metaM aicar c
has only substance units: false
is: CHEBI:58475
type: Species
is: C04677
initial concentration: 1.0
initial amount: NaN
is: HMDB01517
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
constant: false

metaM nadph r
is: CHEBI:57783
is: C00005
is: SBO:0000247
type: Species
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
constant: false
is: HMDB00221
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate - reduced

metaR LEUtec
name: L-leucine transport via diffusion (extracellular to cytosol)
fast: false
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110009#
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reversible: true
modifier: MODEL1310110009#
type: Reaction

metaM pail3p hs c
initial concentration: 1.0
has only substance units: false
is: CHEBI:58088
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
constant: false
is: SBO:0000247
boundary condition: false

metaM ksi deg1 l
is: CHEBI:18287
initial concentration: 1.0
is: SBO:0000247
is: HMDB00174
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
initial amount: NaN
name: keratan sulfate I, degradation product 1
constant: false

metaM cl e
is: HMDB00492
name: Chloride
is: CHEBI:3966
boundary condition: false
has only substance units: false
is: C00115
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: Cl CHARGE: -1
constant: false

metaM subeac x
initial amount: NaN
is: HMDB00893
initial concentration: 1.0
is: SBO:0000247
name: suberic acid
has only substance units: false
constant: false
type: Species
notes: FORMULA: C8H12O4 CHARGE: -2
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_52c721f6_334d_43b3_978c_65ee2d81e456
type: Species
boundary condition: true
name: AOC2
is encoded by: hsa:314
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR S3TASE3ly
is described by: ECO:0000000
product: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
name: N-acetylglucosamine-3-sulfatase, lysosomal
type: Reaction
reactant: MODEL1310110009#
reversible: true
kinetic law: MODEL1310110009#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110009#_10a1fcb4_a6c5_4832_8899_9ccfc8866087
is: Q9Y2Q0
has only substance units: false
type: Species
name: ATP8A1
initial concentration: NaN
constant: false
is encoded by: hsa:10396
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM urate c
is: HMDB00289
name: Urate
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: C00366
has only substance units: false
is: CHEBI:17775
initial amount: NaN
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
boundary condition: false

metaM docohexcoa m
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
constant: false
initial concentration: 1.0
name: 2,4,7,10,13,16-docosahexenoylcoa
notes: FORMULA: C43H62N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110009#_cb43c4a7_ca3b_4346_b57c_cf8b8d4add6d
is: SBO:0000252
name: ATP5C1
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:509
boundary condition: true
constant: false
type: Species
is: Q6I9V2

metaM cl c
type: Species
is: HMDB00492
constant: false
has only substance units: false
is: C00115
notes: FORMULA: Cl CHARGE: -1
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: Chloride
is: CHEBI:3966

metaM dhap e
boundary condition: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
is: SBO:0000247
initial amount: NaN
is: CHEBI:57642
constant: false
has only substance units: false
type: Species
name: glycerone phosphate(2-)
initial concentration: 1.0
is: HMDB01473

metaM ahdt e
has only substance units: false
initial concentration: 1.0
is: HMDB00980
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:58462
type: Species
initial amount: NaN
notes: FORMULA: C9H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C9H16N5O13P3/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-25-29(21,22)27-30(23,24)26-28(18,19)20/h4,6,15-16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,10,11,13,14,17)/p-4/t4-,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01367 EHMN_ABBREVIATION: C04895
name: 7,8-dihydroneopterin 3'-triphosphate(4-)

http://identifiers.org/biomodels.db/MODEL1310110009#_0ef1e0cc_f5f1_49d9_9f72_161f6ef31583
initial amount: NaN
is: P22413
name: ENPP1
boundary condition: true
is encoded by: hsa:5167
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false

metaR DMATTx
reactant: MODEL1310110009#
product: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110009#
is described by: ECO:0000134
reversible: false
name: dimethylallyltranstransferase
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
is version of: http://identifiers.org/ec-code/2.5.1.1

metaM 20ahchsterol m
initial amount: NaN
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
has only substance units: false
is: SBO:0000247
type: Species
name: 20-hydroxycholesterol
is: HMDB06283
initial concentration: 1.0
boundary condition: false
is: CHEBI:1296

http://identifiers.org/biomodels.db/MODEL1310110009#_43ab7c39_48b1_4e52_9712_6fcd17a0836d
has only substance units: false
initial amount: NaN
constant: false
name: _AGPAT7_1_c
boundary condition: true
is encoded by: hsa:AGPAT7
is: SBO:0000252
initial concentration: NaN
type: Species

metaR 3SALATAi
kinetic law: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
name: 3-sulfino-alanine transaminase (irreversible)
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000304
product: MODEL1310110009#
is: SBO:0000176
reactant: MODEL1310110009#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110009#_1212d174_8a92_4ef1_87b9_cb94c2026948
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: HSD17B4
boundary condition: true
is encoded by: hsa:3295
is: E9PB82
type: Species
is: SBO:0000252
constant: false

metaM cs e deg6 l
is: HMDB01354
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C31H48NO32S2 CHARGE: -3
is: CHEBI:57455
type: Species
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6
boundary condition: false
constant: false

metaM leuktrD4 r
is: CHEBI:28666
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: Leukotriene D4
is: HMDB03080
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_7eb5ef56_8563_454d_80c2_03b022870941
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: O60762
is encoded by: hsa:8813
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: DPM1

metaR LEUKTRD4t
is: SBO:0000185
is described by: ECO:0000269
reversible: true
name: leukotriene D4 transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
kinetic law: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
reactant: MODEL1310110009#

metaM fmn e
type: Species
is: C00061
boundary condition: false
is: CHEBI:58210
notes: FORMULA: C17H19N4O9P CHARGE: -2
initial concentration: 1.0
initial amount: NaN
name: FMN
constant: false
is: HMDB01520
is: SBO:0000247
has only substance units: false

metaM C05957 r
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
type: Species
has only substance units: false
name: Prostaglandin J2
is: CHEBI:27485
initial amount: NaN
is: HMDB02710
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR UGLT
is version of: http://identifiers.org/ec-code/2.7.7.12
name: UDPglucose--hexose-1-phosphate uridylyltransferase
type: Reaction
fast: false
modifier: MODEL1310110009#
reversible: true
product: MODEL1310110009#
is: SBO:0000176
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_f92d5ad3_f80f_4ed0_84d0_5c1f2e28afbb
has only substance units: false
is: Q9NUB1
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:84532
initial concentration: NaN
type: Species
name: ACSS1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_e8008a18_ac39_403c_82b7_a7358dd065c6
is: B3KNC1
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
initial concentration: NaN
name: UPB1
is encoded by: hsa:51733
is: SBO:0000252

metaR LNLCCPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
is: SBO:0000176
product: MODEL1310110009#
reversible: false
name: carnitine transferase
reactant: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
modifier: MODEL1310110009#

metaM ksii core2 deg6 l
has only substance units: false
type: Species
notes: FORMULA: C44H72N4O33SX CHARGE: -1
initial amount: NaN
is: CHEBI:12936
boundary condition: false
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 6
constant: false
initial concentration: 1.0
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110009#_a9d54bf2_5a14_4c5b_893b_134bc408a52e
is: SBO:0000252
name: SLC25A1
is: D9HTE9
is encoded by: hsa:6576
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
constant: false

metaR C160CPT1
fast: false
kinetic law: MODEL1310110009#
name: production of Palmitoylcarnitine
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110009#_7ff29bae_ba6b_4d4d_bdd6_30ea96b62deb
initial concentration: NaN
has only substance units: false
is encoded by: hsa:56954
is: Q9NQR4
is: SBO:0000252
boundary condition: true
name: NIT2
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_8857a76a_3ffc_4d48_9e0c_891b19d30d3f
name: SGPP1
is encoded by: hsa:81537
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q9BX95
type: Species
boundary condition: true
constant: false

metaR AHCYStd
name: diffusion of S-Adenosyl-L-homocysteine
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
product: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110009#
is described by: ECO:0000134
type: Reaction

metaR LNLCCPT1
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
is described by: ECO:0000269
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine O-palmitoyltransferase
is: SBO:0000176
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_ce75d446_8547_4b78_81bc_17aaa6559c93
initial amount: NaN
type: Species
name: SLC26A7
boundary condition: true
is encoded by: hsa:115111
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false

metaM urate e
is: C00366
is: CHEBI:17775
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
name: Urate
initial concentration: 1.0
is: SBO:0000247
is: HMDB00289
initial amount: NaN
constant: false

metaR AICARte
is: SBO:0000185
fast: false
is described by: ECO:0000134
product: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110009#_15bb7f86_03c8_4b65_b0e0_ad64635b72df
is encoded by: hsa:29920
has only substance units: false
initial amount: NaN
is: Q96C36
initial concentration: NaN
name: PYCR2
type: Species
constant: false
boundary condition: true
is: SBO:0000252

metaR S4TASE3ly
kinetic law: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.12
product: MODEL1310110009#
reversible: true
is described by: ECO:0000000
name: N-acetylgalactosamine-4-sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110009#_483b31c5_7f13_4afd_b5a7_883a450a7acd
boundary condition: true
initial amount: NaN
type: Species
name: SLC6A3
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:6531
is: SBO:0000252
is: Q01959

metaM nrvnc e
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB02368
constant: false
is: CHEBI:32392
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
name: nervonate

metaM ksii core2 deg2 l
is: CHEBI:12936
type: Species
constant: false
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 2
is: HMDB00143
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C70H114N5O56S2X CHARGE: -2

metaR DOLGLCP Uter
product: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)
is described by: ECO:0000000
is: SBO:0000185

metaR FAS120COA
type: Reaction
reactant: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110009#
name: fatty-acyl-CoA synthase (n-C12:0CoA)
reversible: false
product: MODEL1310110009#

metaR HPDCACRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
type: Reaction
fast: false
reactant: MODEL1310110009#
modifier: MODEL1310110009#
name: heptadecanoate transport into the mitochondria
is described by: ECO:0000269
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000185
reversible: false

metaR PHCHGSm
reversible: true
reactant: MODEL1310110009#
type: Reaction
is: SBO:0000176
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD

metaR AHCYSte
is described by: ECO:0000134
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
name: Transport of S-adenosyl-L-homocysteine
is: SBO:0000185
fast: false
reversible: true

metaR r2121
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110009#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110009#
fast: false
reversible: true
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_d0d9a517_fbfd_4158_abb6_998f48717b46
initial amount: NaN
has only substance units: false
name: RPIA
is: SBO:0000252
boundary condition: true
is encoded by: hsa:22934
constant: false
is: P49247
initial concentration: NaN
type: Species

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaM homoval m
name: Homovanillate
is: SBO:0000247
is: HMDB00118
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:545959
constant: false
initial concentration: 1.0
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582

metaR EX Tyr ggn LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyr-194 of apo-glycogenin protein (primer for glycogen synthesis) exchange
type: Reaction

metaR r0813
fast: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.9
is: SBO:0000185
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:
kinetic law: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
reversible: false
reactant: MODEL1310110009#
modifier: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_1206926c_7268_4d55_9a7f_338a657d5607
is: SBO:0000252
name: ATP5F1
type: Species
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:515
boundary condition: true
initial concentration: NaN
is: Q08ET0

http://identifiers.org/biomodels.db/MODEL1310110009#_57b814be_4fa3_4335_8f53_5bef8db05328
boundary condition: true
is: Q16775
is encoded by: hsa:3029
name: HAGH
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false

metaR PMEVKc
is: SBO:0000176
kinetic law: MODEL1310110009#
is described by: ECO:0000134
name: phosphomevalonate kinase, cytosol
product: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.2
fast: false
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added to substrate for elemental balancing.
reversible: false
reactant: MODEL1310110009#
modifier: MODEL1310110009#

metaM c12dccoa x
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
is: SBO:0000247
type: Species
name: dodecanedioylcoa
is: HMDB03712

http://identifiers.org/biomodels.db/MODEL1310110009#_a67f7146_bff2_498d_b35a_12372fc338fe
is encoded by: hsa:6392
initial amount: NaN
initial concentration: NaN
is: O14521
is: SBO:0000252
constant: false
name: SDHD
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_032704a5_bb36_4bc3_890e_81aa4a225a64
is encoded by: hsa:80025
initial amount: NaN
is: Q6P1K9
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: PANK2
boundary condition: true
type: Species

metaR r2120
type: Reaction
is: SBO:0000185
reactant: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reversible: true
product: MODEL1310110009#
modifier: MODEL1310110009#

metaR KAS8
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110009#
reversible: false
name: b-ketoacyl synthetase (palmitate, n-C16:0)
product: MODEL1310110009#
fast: false
type: Reaction

metaM nrvnc c
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
is: CHEBI:32392
is: HMDB02368
name: nervonate
constant: false
initial concentration: 1.0
has only substance units: false

metaM CE0713 m
is: SBO:0000247
is: CHEBI:30623
boundary condition: false
is: HMDB02329
name: 3-oxolinoleoyl-CoA
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713

http://identifiers.org/biomodels.db/MODEL1310110009#_b73b160f_3235_465b_8371_d68e5df5da88
is encoded by: hsa:160287
is: Q6ZMR3
constant: false
name: LDHAL6A
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_92489b41_55d4_4593_a41c_ae46154760ad
is encoded by: hsa:509
has only substance units: false
name: ATP5C1
initial amount: NaN
is: P36542
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaR ATP2ter
fast: false
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: AMP/ATP transporter, endoplasmic reticulum
product: MODEL1310110009#
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110009#_7940daec_4874_447e_8605_e967cce31270
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: O00443
name: PIK3C2A
is encoded by: hsa:5286
has only substance units: false
boundary condition: true
constant: false
type: Species

metaM 4hpro LT e
name: trans-4-hydroxy-L-proline
is: HMDB00725
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000247

metaR GLYt2r
modifier: MODEL1310110009#
name: glycine reversible transport via proton symport
reactant: MODEL1310110009#
reversible: true
kinetic law: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is described by: ECO:0000304
product: MODEL1310110009#
fast: false
is: SBO:0000185

metaR r0937
reactant: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
kinetic law: MODEL1310110009#
is: SBO:0000185
name: Transport reaction
reversible: true
type: Reaction

metaR LNSTLSr
type: Reaction
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
reactant: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000134
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/5.4.99.7
name: lanosterol synthase
is: SBO:0000176
fast: false
reversible: false

metaR RE0456M
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6997299,PMID:8483833 NOTES:
is: SBO:0000176
product: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
reversible: true
name: RE0456
kinetic law: MODEL1310110009#
fast: false

metaR r1156
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
type: Reaction
reversible: true
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_9d41ffc9_a8de_4d88_a2f3_067d696a1a19
is: P11086
type: Species
initial concentration: NaN
is encoded by: hsa:5409
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: PNMT
boundary condition: true
constant: false

metaM ksi pre12 g
is: HMDB00175
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: C00130
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 12
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110009#_cab0faec_9929_4179_8b28_4ff9e44c7e19
initial amount: NaN
constant: false
boundary condition: true
name: TK1
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:7083
is: P04183

metaM HC02175 e
has only substance units: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
initial amount: NaN
type: Species
is: CHEBI:27689
name: caprate
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_c057a06d_c193_4c33_95a4_83a7af5fc69e
is encoded by: hsa:5634
constant: false
is: P11908
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
name: PRPS2
is: SBO:0000252

metaR 41R1H2MAE12BOOX
modifier: MODEL1310110009#
reversible: false
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110009#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.3.4
name: 4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
fast: false

metaR r0819
is described by: ECO:0000000
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true
kinetic law: MODEL1310110009#
product: MODEL1310110009#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR FATP7t
kinetic law: MODEL1310110009#
is: SBO:0000185
modifier: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.7
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
reactant: MODEL1310110009#
name: fatty acid electroneutral transport

metaM HC01007 m
notes: FORMULA: C15H29NO4 CHARGE: 0 INCHI: InChI=1S/C15H29NO4/c1-5-6-7-8-9-10-15(19)20-13(11-14(17)18)12-16(2,3)4/h13H,5-12H2,1-4H3/t13-/m0/s1 EHMN_ABBREVIATION: C02838
constant: false
is: CHEBI:18102
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: L-Octanoylcarnitine
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_89abc191_0ff9_4b38_b867_bdaf5b723f4c
boundary condition: true
has part: P48736
is: SBO:0000297
has only substance units: false
name: HCST:PIK3CG
is encoded by: hsa:5294
has part: Q9UBK5
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:10870

http://identifiers.org/biomodels.db/MODEL1310110009#_026ee0b4_fb03_4277_af89_91d9828d1693
is encoded by: hsa:271
is: Q01433
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: AMPD2
has only substance units: false
constant: false

metaR r0936
reversible: false
type: Reaction
fast: false
is: SBO:0000185
name: Transport reaction
reactant: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110009#

metaR PROSTGE2t
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reversible: true
reactant: MODEL1310110009#
type: Reaction
fast: false
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185
product: MODEL1310110009#
name: prostaglandin transport via bicarbonate countertransport
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110009#_8faf6295_73ec_4dc4_96a1_02acb08f816a
has only substance units: false
is: Q3I5F7
boundary condition: true
is encoded by: hsa:641372
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
name: ACOT6

http://identifiers.org/biomodels.db/MODEL1310110009#_8cec8606_fea9_40d2_a193_7bdbf0991f50
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: SLC22A4
has only substance units: false
constant: false
type: Species
is encoded by: hsa:6583
is: Q9H015

http://identifiers.org/biomodels.db/MODEL1310110009#_8af152e3_8e65_4fee_87b5_486a40dea8c4
is encoded by: hsa:51557
initial concentration: NaN
boundary condition: true
is: Q5TDP6
constant: false
is: SBO:0000252
has only substance units: false
name: LGSN
initial amount: NaN
type: Species

metaM 4hpro LT c
is: CHEBI:18095
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
initial concentration: 1.0
type: Species
is: HMDB00725
name: trans-4-hydroxy-L-proline
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false

metaR CGLYt3 2
type: Reaction
reactant: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000185
name: Cys-Gly transport in via proton symport
modifier: MODEL1310110009#
reversible: false
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110009#

metaR NCNt
modifier: MODEL1310110009#
reversible: true
fast: false
name: Na+/Ca2+-NH4+ exchange
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110009#_7eed27f4_6a55_4a01_adf0_c6a149586631
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1629
is: P11182
has only substance units: false
type: Species
boundary condition: true
name: DBT
is: SBO:0000252

metaR NACHEX19ly
modifier: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
kinetic law: MODEL1310110009#
fast: false
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110009#
is described by: ECO:0000000
reversible: false

metaR SUCCTD
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaR r0818
is described by: ECO:0000000
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
reversible: false
type: Reaction
fast: false
name: Transport reaction
is: SBO:0000185
product: MODEL1310110009#

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_287b8062_4dd2_46ca_9703_2598c6e17e20
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
name: SLC2A13
initial amount: NaN
type: Species
is: Q96QE2
initial concentration: NaN
is encoded by: hsa:114134

http://identifiers.org/biomodels.db/MODEL1310110009#_ff84892d_f9bb_4b8b_b6ff_f952f0532f8e
constant: false
is: P80365
has only substance units: false
type: Species
initial concentration: NaN
name: HSD11B2
initial amount: NaN
boundary condition: true
is encoded by: hsa:3291
is: SBO:0000252

metaM HC02175 c
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
is: CHEBI:27689
is: SBO:0000247
initial concentration: 1.0
name: caprate
type: Species
boundary condition: false

metaR RE3009C
kinetic law: MODEL1310110009#
product: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
is: SBO:0000176
name: RE3009
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
type: Reaction

metaM nadph x
is: CHEBI:57783
is: HMDB00221
is: SBO:0000247
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial concentration: 1.0
boundary condition: false
is: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaM 4mzym int2 r
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
initial amount: NaN
is: HMDB06838
name: 4-Methylzymosterol intermediate 2
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false

metaR THRSERNaEx
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110009#
kinetic law: MODEL1310110009#
name: L-serine/L-threonine Na-dependent exchange (Thr-L in)
reversible: false
is: SBO:0000185
reactant: MODEL1310110009#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110009#

metaR r0817
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
product: MODEL1310110009#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.41
kinetic law: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:

metaR SPHS1Pte
type: Reaction
is described by: ECO:0000000
product: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
is: SBO:0000185
name: sphingosine-1-phosphate transport
reversible: true
kinetic law: MODEL1310110009#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_d79666c1_dd64_4b2d_81d1_d8cf6e83a5ef
type: Species
is encoded by: hsa:229
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: ALDOB
has only substance units: false
is: SBO:0000252
is: P05062
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_834ec253_efb4_42f1_9cf2_8868e19d065a
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
type: Species
name: SLC23A2
is: SBO:0000252
is encoded by: hsa:9962

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaM man1p c
is: HMDB06330
is: SBO:0000247
name: D-Mannose 1-phosphate
is: CHEBI:35374
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_ecf61a5f_b275_4f91_8d6a_9f88589db303
is: P04062
name: GBA
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:2629
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_d137806d_5a84_4914_81f9_063833316e4f
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2348
name: FOLR1
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
type: Species

metaR HISD
is version of: http://identifiers.org/ec-code/4.3.1.3
is: SBO:0000176
reactant: MODEL1310110009#
reversible: false
fast: false
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
kinetic law: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
name: histidase
is described by: ECO:0000269

metaR r2126
is: SBO:0000185
type: Reaction
modifier: MODEL1310110009#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_dfc3bc83_0b5e_4a58_b3c7_51b7a1f5ce99
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:57665
constant: false
boundary condition: true
initial amount: NaN
is: Q9HBH5
has only substance units: false
name: RDH14

http://identifiers.org/biomodels.db/MODEL1310110009#_d3bace66_ddfc_48e0_84c5_b6de8debd847
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10195
constant: false
initial concentration: NaN
type: Species
name: ALG3

metaR r1571
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction

metaR TAURt4 2 r
product: MODEL1310110009#
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
name: taurine transport (sodium symport) (2:1)
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110009#
type: Reaction
reversible: true
fast: false

metaR r0295
type: Reaction
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: false
is: SBO:0000176
product: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
is described by: ECO:0000000

metaM ppa e
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:17272
name: propionate
is: HMDB00237
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial concentration: 1.0

metaR EX sprm LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_sprm(e)
type: Reaction

metaR RPI
is version of: http://identifiers.org/ec-code/5.3.1.6
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
product: MODEL1310110009#
modifier: MODEL1310110009#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110009#
name: ribose-5-phosphate isomerase
type: Reaction
reactant: MODEL1310110009#

metaR GAMYe
name: glucoamylase, extracellular (glygn5 -> malt)
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8972.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.3 Confidence Level: 4 AUTHORS: PMID:3143729 NOTES:NCD
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reversible: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.20

metaR FE3MTP1
modifier: MODEL1310110009#
fast: false
is described by: ECO:0000134
name: transport of ferrous iron into blood
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
reversible: false

metaR r0932
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110009#
name: Transport reaction
product: MODEL1310110009#
reactant: MODEL1310110009#

metaR EX c3dc
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for malonyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_a82f2dd7_0035_45f1_8177_31494bd00709
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:6647
is: P00441
name: SOD1
is: SBO:0000252

metaM sebacid x
is: C08277
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C10H16O4 CHARGE: -2
initial concentration: 1.0
name: sebacicacid
constant: false
is: HMDB00792
has only substance units: false

metaR r1378
fast: false
is described by: ECO:0000000
product: MODEL1310110009#
is: SBO:0000176
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
type: Reaction
reversible: true
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
reactant: MODEL1310110009#

metaM acrn c
is: HMDB00201
type: Species
has only substance units: false
name: O-acetylcarnitine
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
initial concentration: 1.0
is: CHEBI:57589

metaM eipencoa x
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
name: 2,5,8,11,14-eicosapentaenoylcoa
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_b323e517_d4d4_45e9_bc1a_7726d79cd79d
is: SBO:0000252
name: SLC3A2
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: P08195
type: Species
is encoded by: hsa:6520
constant: false
has only substance units: false

metaR r2127
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110009#
reactant: MODEL1310110009#
product: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110009#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r1570
is described by: ECO:0000000
product: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110009#
is: SBO:0000185
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110009#_217838f5_06fe_4148_b365_5936c6e30513
is: Q86YU0
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:766
boundary condition: true
name: CA7
initial amount: NaN
constant: false

metaM HC01118 r
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
boundary condition: false
type: Species
is: SBO:0000247
name: presqualene diphosphate(3-)
constant: false
is: CHEBI:57310
has only substance units: false

metaR RE3421R
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: RE3421
reversible: true
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
product: MODEL1310110009#

metaR SPHMYLNtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
product: MODEL1310110009#
name: sphingomyelin intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110009#_7533340a_cb3d_4f9d_b5c4_a6f55ae03080
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: SLC27A5
type: Species
constant: false
is encoded by: hsa:10998
initial amount: NaN
is: Q9Y2P5

metaM acetone e
is: HMDB01659
constant: false
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: acetone
is: CHEBI:15347
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: SBO:0000247

metaM ksi deg6 l
boundary condition: false
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
constant: false
is: CHEBI:12936
is: HMDB00143
name: keratan sulfate I, degradation product 6
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM nadph c
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial amount: NaN
is: HMDB00221
has only substance units: false
boundary condition: false
type: Species
name: Nicotinamide adenine dinucleotide phosphate - reduced
constant: false
is: SBO:0000247
initial concentration: 1.0
is: C00005
is: CHEBI:57783

metaM thymd c
type: Species
constant: false
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
has only substance units: false
name: Thymidine
boundary condition: false
is: SBO:0000247
is: C00214
is: HMDB00273
initial concentration: 1.0
is: CHEBI:17748
initial amount: NaN

metaR r1377
reactant: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
is: SBO:0000176
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110009#

metaM bilglcur c
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: CHEBI:57767
has only substance units: false
boundary condition: false
initial amount: NaN
name: mono(glucosyluronic acid)bilirubin(2-)

metaR r1573
is described by: ECO:0000000
kinetic law: MODEL1310110009#
product: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110009#
type: Reaction
reversible: true

metaR DCMPDA
is described by: ECO:0000254
fast: false
reactant: MODEL1310110009#
name: dCMP deaminase
kinetic law: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.12
modifier: MODEL1310110009#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110009#_74c69973_b1d3_478a_aebf_2ca57c77ac80
is: SBO:0000252
is: O14734
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: ACOT8
is encoded by: hsa:10005
type: Species
boundary condition: true

metaR r2128
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110009#
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110009#
reversible: true

metaR HDCAtr
kinetic law: MODEL1310110009#
is: SBO:0000185
name: fatty acid transport via diffusion
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
reversible: true
fast: false

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaM CE2434 m
constant: false
is: CHEBI:57795
initial amount: NaN
has only substance units: false
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
boundary condition: false

metaR G14Tg
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110009#
is described by: ECO:0000269
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
is: SBO:0000176
type: Reaction
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR PMANM
type: Reaction
is described by: ECO:0000000
name: phosphomannomutase
kinetic law: MODEL1310110009#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110009#
product: MODEL1310110009#
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/5.4.2.2
is version of: http://identifiers.org/ec-code/5.4.2.8

metaM g3m8mpdol U r
is: SBO:0000247
notes: FORMULA: C1905H3140N20O770P20 CHARGE: -20
type: Species
initial amount: NaN
constant: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
is: C05873
boundary condition: false
has only substance units: false

metaR C51CPT1
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tiglylcarnitine
type: Reaction

metaR NDP8ex
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
is described by: ECO:0000269
product: MODEL1310110009#
name: nucleoside-diphosphatase (UTP), extracellular
kinetic law: MODEL1310110009#
is: SBO:0000176
modifier: MODEL1310110009#
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.6
type: Reaction
fast: false

metaM dcamp c
initial concentration: 1.0
constant: false
name: N6-(1,2-Dicarboxyethyl)-AMP
is: SBO:0000247
is: C03794
is: CHEBI:57567
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00536

metaR S6T11g
product: MODEL1310110009#
reversible: false
kinetic law: MODEL1310110009#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
modifier: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110009#

metaR r2129
type: Reaction
kinetic law: MODEL1310110009#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110009#
fast: false
product: MODEL1310110009#
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR PHYCBOXL
reactant: MODEL1310110009#
reversible: false
fast: false
kinetic law: MODEL1310110009#
is described by: ECO:0000212
type: Reaction
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
modifier: MODEL1310110009#
name: L-Phenylalanine carboxy-lyase
is: SBO:0000176
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/4.1.1.28

http://identifiers.org/biomodels.db/MODEL1310110009#_731919d6_6806_4168_9b12_7376d6dc2168
is encoded by: hsa:130367
constant: false
has only substance units: false
initial amount: NaN
is: Q8IWX5
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
name: SGPP2

metaR DGNSKm
reversible: false
modifier: MODEL1310110009#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.113
product: MODEL1310110009#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1716.5) or (1716.1) or (1716.4) or (1716.2) or (1716.3) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:8692979 NOTES:
name: deoxyguanosine kinase
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000176

metaM c8dc x
constant: false
type: Species
is: HMDB00893
name: suberyl carnitine
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C15H26NO6 CHARGE: -1

metaR GASNASEly
name: glycosylasparaginase, lysosomal
reversible: false
is: SBO:0000176
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.26
fast: false
modifier: MODEL1310110009#

metaR C81CRNe
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octenoyl carnitine into the extra cellular space
type: Reaction

metaM subeac c
constant: false
is: HMDB00893
has only substance units: false
notes: FORMULA: C8H12O4 CHARGE: -2
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: suberic acid
initial amount: NaN
type: Species

metaR EX aprgstrn LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 20alpha-Hydroxyprogesterone exchange
type: Reaction

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaR r0931
kinetic law: MODEL1310110009#
type: Reaction
name: Transport reaction
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000185
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110009#

metaR DNDPt14m
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110009#
fast: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
name: dUDP transport via dTDP antiport
reversible: false

metaR 4NPHSFte
is: SBO:0000185
name: xenobiotic transport
reversible: true
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
fast: false
type: Reaction

metaR BTND1
reversible: false
modifier: MODEL1310110009#
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:IT
is version of: http://identifiers.org/ec-code/3.5.1.12
is described by: ECO:0000269
product: MODEL1310110009#
reactant: MODEL1310110009#
name: biotinidase (biotin)
kinetic law: MODEL1310110009#

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaR r2122
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110009#

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_7d11ede2_3e40_44c7_a8fe_6c9f7972fe1f
is: Q01415
is: SBO:0000252
type: Species
initial concentration: NaN
name: GALK2
boundary condition: true
has only substance units: false
is encoded by: hsa:2585
initial amount: NaN
constant: false

metaR KSItly
kinetic law: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110009#
reversible: false
name: keratan sulfate I transport, extracellular to lysosome

http://identifiers.org/biomodels.db/MODEL1310110009#_d012b66e_6f89_4426_b3a0_b19f784fa008
constant: false
is encoded by: hsa:AA278423
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: _AA278423_1_m
has only substance units: false

metaR O2St
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
name: superoxide anion transport via diffusion (extracellular)
product: MODEL1310110009#

metaM phytcoa x
initial amount: NaN
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
name: phytanoyl-CoA(4-)
is: SBO:0000247
is: CHEBI:57391
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
is: HMDB01359
has only substance units: false

metaR DM anth
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR FAOXC226C225m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

metaM pi x
is: HMDB00973
constant: false
type: Species
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:43474
initial concentration: 1.0

metaM retinal 11 cis c
has only substance units: false
boundary condition: false
name: 11-cis-retinal
is: HMDB02152
is: SBO:0000247
constant: false
type: Species
is: CHEBI:16066
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
initial amount: NaN
initial concentration: 1.0

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaR VALTA
type: Reaction
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.6.1.42
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
is: SBO:0000176
reactant: MODEL1310110009#
reversible: true
fast: false
product: MODEL1310110009#
is described by: ECO:0000269
name: valine transaminase

metaM tdcoa m
is: SBO:0000247
is: C02593
is: HMDB01521
initial concentration: 1.0
is: CHEBI:57385
constant: false
boundary condition: false
initial amount: NaN
name: Tetradecanoyl-CoA (n-C14:0CoA)
type: Species
has only substance units: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaR NACHEX2ly
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110009#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110009#
modifier: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_95bd03e6_1571_4519_8797_ac59d1eb29f3
is: SBO:0000252
boundary condition: true
name: SLC38A4
has only substance units: false
type: Species
is encoded by: hsa:55089
initial amount: NaN
initial concentration: NaN
is: Q969I6
constant: false

metaR r0074
reactant: MODEL1310110009#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.1
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
product: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
type: Reaction
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
modifier: MODEL1310110009#

metaM ksi deg22 l
is: SBO:0000247
is: HMDB01354
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C132H214N9O111S5 CHARGE: -5
is: CHEBI:57455
constant: false
initial amount: NaN
name: keratan sulfate I, degradation product 22
type: Species
has only substance units: false

metaR CRNtHa
name: L-carnitine outward transport (H+ antiport)
type: Reaction
fast: false
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (6583.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB H+ stoichiometry unknown
product: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185

metaR r2123
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
product: MODEL1310110009#
modifier: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_1fc71c4f_1400_47bd_9f4e_b92d89a4a8e0
constant: false
boundary condition: true
is encoded by: hsa:223
is: P49189
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: ALDH9A1
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_5b2370a8_14e1_478c_8f15_34aeef76b018
is: SBO:0000252
is: B3KN25
type: Species
name: CEPT1
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10390

metaR DGULND
name: dehydro-L-gulonate decarboxylase
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110009#_764549f7_5c41_432a_9394_12d081c6a3e8
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: P07864
initial amount: NaN
constant: false
boundary condition: true
type: Species
name: LDHC
is encoded by: hsa:3948

metaM 4hpro LT m
is: SBO:0000247
initial concentration: 1.0
is: HMDB00725
name: trans-4-hydroxy-L-proline
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:18095
boundary condition: false
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690

http://identifiers.org/biomodels.db/MODEL1310110009#_dcc410d1_e34d_4c8f_8313_f6548dce7482
boundary condition: true
is encoded by: hsa:6489
initial amount: NaN
name: ST8SIA1
initial concentration: NaN
is: Q92185
has only substance units: false
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_0495c3da_7906_4bb3_b825_312f9c7bc767
is: SBO:0000252
boundary condition: true
name: ALDH1A1
is encoded by: hsa:216
is: P00352
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false

metaM adrn c
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:53487
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
is: HMDB02226
constant: false
name: adrenic acid

metaR r0812
product: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.41
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
reversible: true
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
type: Reaction
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_4772a660_53bf_4530_91d1_9d5d43305e7b
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
name: BDH1
has only substance units: false
boundary condition: true
is encoded by: hsa:622
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_cbac7e6d_dd2e_4ee3_be67_f674fd3e308e
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: ATP5J
has only substance units: false
constant: false
is encoded by: hsa:522
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_e9334acd_f2a9_44f1_8c2c_b11d3f9750d5
type: Species
initial amount: NaN
name: _AI971036_1_x
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI971036
constant: false

metaR BILGLCURtr
product: MODEL1310110009#
is: SBO:0000185
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
reversible: true
name: glucuronidated compound transport
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ

metaM ppa c
constant: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: CHEBI:17272
has only substance units: false
initial amount: NaN
name: propionate
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00237

metaR ADPCOAPTE
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of adipoyl coA for release into cytosol
type: Reaction

metaR r2124
is: SBO:0000185
modifier: MODEL1310110009#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110009#
product: MODEL1310110009#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110009#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_1676b318_77fa_4109_8b7a_a1998f70a10b
constant: false
is: E9PH29
name: PRDX3
is encoded by: hsa:10935
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR S6TASE9ly
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110009#
type: Reaction
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110009#

metaM HC01007 c
notes: FORMULA: C15H29NO4 CHARGE: 0 INCHI: InChI=1S/C15H29NO4/c1-5-6-7-8-9-10-15(19)20-13(11-14(17)18)12-16(2,3)4/h13H,5-12H2,1-4H3/t13-/m0/s1 EHMN_ABBREVIATION: C02838
name: L-Octanoylcarnitine
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:18102
boundary condition: false
constant: false
is: SBO:0000247

metaR GLNCYSNaEx
fast: false
name: L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110009#
reversible: false
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is described by: ECO:0000269
reactant: MODEL1310110009#
type: Reaction

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_e0b46165_b897_4101_be03_e07cac6907ad
constant: false
is: Q9NSW9
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: SLC9A5
is encoded by: hsa:6553
boundary condition: true
is: SBO:0000252

metaM decdicoa c
initial concentration: 1.0
type: Species
is: HMDB01168
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
name: decadienoylcoa
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN

metaR DNDPt25m
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
is: SBO:0000185
fast: false
kinetic law: MODEL1310110009#
type: Reaction
modifier: MODEL1310110009#
reactant: MODEL1310110009#
reversible: false
name: dTDP transport via dCDP antiport

http://identifiers.org/biomodels.db/MODEL1310110009#_2e8b5a36_d0af_4eac_acd1_5b56fc3b31a3
type: Species
name: ALAS2
has only substance units: false
is: Q5JZF5
is: SBO:0000252
is encoded by: hsa:212
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true

metaR r2125
type: Reaction
modifier: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110009#
is: SBO:0000185
product: MODEL1310110009#
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_22bf6762_3924_48f2_b7c5_b640bdfa41f2
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: AK2
boundary condition: true
is encoded by: hsa:204

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaM o2 x
type: Species
constant: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
name: O2
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: C00007
is: HMDB01377
is: CHEBI:15379

http://identifiers.org/biomodels.db/MODEL1310110009#_9d927ce2_dd10_49d6_86c7_698266c2eb12
initial concentration: NaN
is: SBO:0000252
constant: false
is: P22413
boundary condition: true
name: ENPP1
is encoded by: hsa:5167
has only substance units: false
type: Species
initial amount: NaN

metaR S2L2N2M2MASNtly
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185
reactant: MODEL1310110009#
name: s2l2n2m2masn transport, extracellular to lysosome
fast: false

metaM adrn e
initial amount: NaN
name: adrenic acid
is: SBO:0000247
is: CHEBI:53487
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB02226
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
constant: false

metaM HC02121 c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
is: SBO:0000247
type: Species
constant: false
name: S-(hydroxymethyl)glutathione(1-)
is: CHEBI:58758
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_cd4b108c_8929_4f6d_8c39_d12d744ed93d
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is: P31350
has only substance units: false
name: RRM2
initial amount: NaN
constant: false
is encoded by: hsa:6241

metaR 34DHPHELAT1tc
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3,4-Dihydroxy-L-phenylalanine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

metaR ACACT5p
product: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is described by: ECO:0000269
reversible: false
fast: false
is: SBO:0000176
reactant: MODEL1310110009#
modifier: MODEL1310110009#

metaR r1579
is described by: ECO:0000000
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110009#
reversible: true
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_ebd2f856_7606_474e_95eb_41f6f9fb6e20
is encoded by: hsa:22305
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: _22305_1_c
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_b23f8c91_70a5_4eb9_b4fc_f48fefad13d0
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
name: CYP27A1
is: Q02318
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:1593

metaM i e
name: iodide
is: SBO:0000247
is: CHEBI:16382
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: HMDB12238
boundary condition: false
initial amount: NaN

metaR MDHm
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.37
fast: false
type: Reaction
name: malate dehydrogenase, mitochondrial
reversible: true
is: SBO:0000176
modifier: MODEL1310110009#
is described by: ECO:0000134

metaM HC02210 c
type: Species
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
name: prostaglandin-d3
boundary condition: false
initial concentration: 1.0
is: CHEBI:34939
is: SBO:0000247

metaM HC02204 e
initial amount: NaN
is: SBO:0000247
name: prostaglandin-b1
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:27624
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
initial concentration: 1.0
type: Species

metaM leuktrD4 c
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB03080
type: Species
constant: false
name: Leukotriene D4
is: CHEBI:28666
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_9bc56826_ef2b_4b31_81ae_b3c98e415857
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3906
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: LALBA
is: P00709
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_0e68ed63_a50b_4b09_becb_0627c9f139fe
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:115584
is: SBO:0000252
name: SLC5A11
type: Species
initial amount: NaN
constant: false
is: Q8WWX8

metaR IZPN
kinetic law: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
is described by: ECO:0000000
is: SBO:0000176
name: Imidazolonepropionase
type: Reaction
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_fb52e56c_bb8d_4f1a_8b1e_258de47439bf
boundary condition: true
type: Species
is encoded by: hsa:4048
constant: false
name: LTA4H
has only substance units: false
is: SBO:0000252
is: P09960
initial amount: NaN
initial concentration: NaN

metaM ala L e
is: CHEBI:16977
is: SBO:0000247
is: HMDB00161
name: L-alanine
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
boundary condition: false
type: Species
initial amount: NaN

metaM triodthy e
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
initial concentration: 1.0
name: 3,3',5-triiodo-L-thyronine
is: CHEBI:18258
type: Species
is: HMDB00265
has only substance units: false

metaR r1578
product: MODEL1310110009#
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_cb1ecbe1_9a79_4b6a_bb75_8690ddeb51c6
is: SBO:0000252
initial concentration: NaN
name: ABCA1
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: O95477
is encoded by: hsa:19

metaM 3hexdtricoa m
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: HMDB02288
initial amount: NaN
name: 3,7,10-hexadecatrienoylcoa
notes: FORMULA: C37H56N7O17P3S CHARGE: -4

metaM Rtotal c
is: CHEBI:16189
initial concentration: 1.0
name: R total
boundary condition: false
notes: FORMULA: CO2FULLR CHARGE: -1
has only substance units: false
type: Species
constant: false
is: HMDB01448
is: SBO:0000247
initial amount: NaN

metaR r2014
is: SBO:0000185
type: Reaction
modifier: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110009#
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_05dd1d12_38ae_468b_870c_a38d2641aac9
is encoded by: hsa:6389
is: SBO:0000252
name: SDHA
has only substance units: false
boundary condition: true
constant: false
is: P31040
type: Species
initial amount: NaN
initial concentration: NaN

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaM hexdectecoa m
has only substance units: false
boundary condition: false
name: 2,4,7,10-hexadecatetraenoylcoa
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: HMDB02288

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaM aicar e
notes: FORMULA: C9H13N4O8P CHARGE: -2
is: C04677
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: CHEBI:58475
is: HMDB01517

metaR FAOXC12DCc
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: formation of dodecanedioyl carnitine
type: Reaction

metaR EX adp
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adp exchange
type: Reaction

metaR EX leuleu LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylleucine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_ea329a10_5483_425e_b357_96f685a66528
is encoded by: hsa:AU149534
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
name: _AU149534_1_c
constant: false

metaM leuktrD4 e
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
initial amount: NaN
is: CHEBI:28666
name: Leukotriene D4
is: HMDB03080
type: Species

metaR PI34P5K
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
is described by: ECO:0000000
fast: false
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.7.1.68
modifier: MODEL1310110009#
name: phosphatidylinositol 3,4-bisphosphate 5-kinase

http://identifiers.org/biomodels.db/MODEL1310110009#_aec9013f_15e2_496b_b406_297bea8cf7fd
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: OXSM
type: Species
initial concentration: NaN
is: Q9NWU1
constant: false
has only substance units: false
is encoded by: hsa:54995

metaM triodthy c
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: 3,3',5-triiodo-L-thyronine
is: HMDB00265
boundary condition: false
is: CHEBI:18258
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465

metaR G14T10g
reactant: MODEL1310110009#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
reversible: false
fast: false
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

metaM ala L c
name: L-alanine
is: CHEBI:16977
initial amount: NaN
is: SBO:0000247
is: HMDB00161
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
boundary condition: false
constant: false
type: Species

metaM nadph m
name: Nicotinamide adenine dinucleotide phosphate - reduced
has only substance units: false
is: CHEBI:57783
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: C00005
is: SBO:0000247
initial amount: NaN
is: HMDB00221
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_0c5c6ebe_2b43_4a4e_8cac_dd58677b867c
has only substance units: false
is: Q7L266
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:80150
name: ASRGL1

metaM ibcoa m
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: isobutyryl-CoA(4-)
constant: false
is: HMDB01243
initial amount: NaN
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
type: Species
is: CHEBI:57338

metaR 5ADTSTSTERONEte
is: SBO:0000185
fast: false
reactant: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
reversible: true
name: 5 alpha dihydrotesterone transport
product: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaM Rtotal e
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:3554
initial amount: NaN
is: C00255
name: R total
type: Species
boundary condition: false
is: HMDB00244
notes: FORMULA: CO2FULLR CHARGE: -1
constant: false
has only substance units: false

metaR r2519
name: Utilized transport
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
product: MODEL1310110009#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:

metaR RE2988X
type: Reaction
name: RE2988
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110009#
reversible: true
product: MODEL1310110009#
is: SBO:0000176
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
modifier: MODEL1310110009#

metaR RPE
fast: false
is version of: http://identifiers.org/ec-code/5.1.3.1
product: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
name: ribulose 5-phosphate 3-epimerase
modifier: MODEL1310110009#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP

http://identifiers.org/biomodels.db/MODEL1310110009#_ec823481_6f81_433c_a70c_05a79f5a41f8
initial amount: NaN
name: DPAGT1
is encoded by: hsa:1798
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR r2516
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000185

metaM bilglcur e
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:57767
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
type: Species
constant: false
boundary condition: false
name: mono(glucosyluronic acid)bilirubin(2-)

metaR XYLt
kinetic law: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
is described by: ECO:0000269
name: D-xylose reversible transport
product: MODEL1310110009#
is: SBO:0000185
fast: false
modifier: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#

metaR r1575
is described by: ECO:0000000
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110009#
is: SBO:0000185
type: Reaction
reversible: true

metaM e4p c
initial concentration: 1.0
initial amount: NaN
type: Species
is: C00279
has only substance units: false
is: SBO:0000247
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
constant: false
name: D-Erythrose 4-phosphate
is: CHEBI:16897
boundary condition: false
is: HMDB01321

http://identifiers.org/biomodels.db/MODEL1310110009#_ff9f332c_5ded_402e_951c_a055f14f83a1
is: P07864
boundary condition: true
initial amount: NaN
has only substance units: false
name: LDHC
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:3948

metaR r1789
reversible: false
type: Reaction
modifier: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000185
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110009#

metaR RE2999M
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE2999
reactant: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/5.3.3.8
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is: SBO:0000176
fast: false
product: MODEL1310110009#
modifier: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_62448c8e_1857_4c7a_a5f1_ed9583fe1e32
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:8836
constant: false
initial concentration: NaN
name: GGH
is: SBO:0000252
is: Q92820
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_967b444e_59cd_4405_ae74_5ff9bb29459d
constant: false
name: TST
is: Q16762
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:7263

metaM fgam c
is: CHEBI:58426
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB01308
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
type: Species
is: C04376

http://identifiers.org/biomodels.db/MODEL1310110009#_ce8fb4b1_0751_4039_b36d_a4716dc51766
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q9Y633
constant: false
initial concentration: NaN
is: SBO:0000252
name: PDE1A
is encoded by: hsa:5136
type: Species

metaR SBCOAACOTx
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of suberyl coa for release into cytosol
type: Reaction

metaR r1574
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110009#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000000

metaM tdcoa c
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: HMDB01521
is: CHEBI:57385
boundary condition: false
initial concentration: 1.0
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: C02593
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593

metaM adn e
constant: false
is: HMDB00050
boundary condition: false
is: C00212
has only substance units: false
is: CHEBI:16335
initial amount: NaN
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
initial concentration: 1.0
name: Adenosine
type: Species
is: SBO:0000247

metaR BALAPAT1tc
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of beta alanine by PAT1 in renal and intestinal cells
type: Reaction

metaR FACOAL80i
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
reactant: MODEL1310110009#
name: fatty-acid--CoA ligase (octanoate)
is: SBO:0000176
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
modifier: MODEL1310110009#
product: MODEL1310110009#

metaM ksi deg1 e
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
constant: false
name: keratan sulfate I, degradation product 1
is: HMDB00211
initial amount: NaN
is: CHEBI:17268

metaR PTCRTD
fast: false
reversible: true
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
kinetic law: MODEL1310110009#
is: SBO:0000185
product: MODEL1310110009#
name: diffusion of putriscine into the endothelial cells
reactant: MODEL1310110009#

metaM zymst r
constant: false
name: zymosterol
is: HMDB06271
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
initial concentration: 1.0
boundary condition: false
is: CHEBI:18252

metaM tetdece1coa c
type: Species
name: tetradecenoylcoa
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB05066
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
initial amount: NaN

metaM pmtcoa c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: SBO:0000247
is: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
is: HMDB01338
type: Species
constant: false
has only substance units: false
is: CHEBI:3454
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110009#_2dcb00ab_1a12_485a_b860_57601628bf1a
initial amount: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:AA854479
initial concentration: NaN
name: _AA854479_1_m
boundary condition: true
is: SBO:0000252

metaR r2514
is: SBO:0000185
product: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
reversible: true
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
fast: false

metaM HC02210 e
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
has only substance units: false
name: prostaglandin-d3
is: CHEBI:34939
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN

metaM 2octdectecoa m
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/5280355
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
name: 2,6,9,12-octadecatetraenoylcoa

metaR FAOXC226C225x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)x
type: Reaction

metaM HC02204 c
initial amount: NaN
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
initial concentration: 1.0
is: CHEBI:27624
name: prostaglandin-b1
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false

metaR PRISTCOAtcx
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

metaM HC00229 e
is: CHEBI:28189
initial amount: NaN
type: Species
initial concentration: 1.0
name: Isomaltose
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false

metaR S2TASE3ly
reversible: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
product: MODEL1310110009#
name: iduronate-2-sulfatase, lysosomal
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.13

http://identifiers.org/biomodels.db/MODEL1310110009#_7727f75e_8f0b_4bf6_ad4f_1362b929984b
constant: false
name: _AI469183_1_x
is encoded by: hsa:AI469183
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_9537b33b_5629_41f4_8748_04cc29e07c9e
initial amount: NaN
is: Q7GXZ8
name: COX2
is: SBO:0000252
is encoded by: hsa:4513
has only substance units: false
type: Species
boundary condition: true
constant: false
initial concentration: NaN

metaM acetone c
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
has only substance units: false
is: HMDB01659
type: Species
name: acetone
is: CHEBI:15347
is: SBO:0000247
boundary condition: false

metaR TYMSFt
is described by: ECO:0000000
name: Tyramine O-sulfate transport (diffusion)
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reversible: false
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
fast: false
is: SBO:0000185
type: Reaction

metaM CE1943 e
is: CHEBI:30623
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: HMDB02329
initial amount: NaN
is: SBO:0000247
name: spermidine dialdehyde
notes: FORMULA: C7H14NO2 CHARGE: 1 INCHI: InChI=1/C7H13NO2/c9-6-2-1-4-8-5-3-7-10/h6-8H,1-5H2/p+1 EHMN_ABBREVIATION: CE1943
boundary condition: false

metaR r1576
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110009#
fast: false
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_5b9f9552_2922_4a5a_b2ea_d9ab27edf7a4
is encoded by: hsa:AI348006
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
name: _AI348006_1_c
initial amount: NaN

metaM acrn m
name: O-acetylcarnitine
is: HMDB00201
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: CHEBI:57589
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN

metaR VLCSr
is: SBO:0000176
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
product: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110009#
is described by: ECO:0000269
name: Very-long-chain-fatty-acid-CoA ligase

metaM man6p c
is: CHEBI:17369
initial amount: NaN
name: D-Mannose 6-phosphate
type: Species
has only substance units: false
is: HMDB01078
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275

metaR CO2ter
type: Reaction
fast: false
kinetic law: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: CO2 endoplasmic reticular transport via diffusion
product: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000185

metaR EX 3deccrn
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydecanoyl carnitine
type: Reaction

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_72fe62b3_02f5_4afe_9ac4_59c3997f5831
is encoded by: hsa:1717
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: DHCR7
is: Q9UBM7
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_da81cd87_f663_450d_9504_38dcab78b59e
initial amount: NaN
name: SLC4A3
is: SBO:0000252
is encoded by: hsa:6508
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
constant: false

metaR CHSTEROLt2
fast: false
type: Reaction
kinetic law: MODEL1310110009#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110009#
name: cholesterol intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110009#

metaM 4hexdtetcoa m
initial amount: NaN
is: HMDB02288
is: SBO:0000247
constant: false
name: 4,7,10,13-hexadecatetraenoylcoa
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM ocdca c
is: HMDB00827
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
boundary condition: false
constant: false
name: stearate
is: CHEBI:25629
initial concentration: 1.0
initial amount: NaN

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_b20e2a82_aab2_4978_867d_4f6ed8efd74e
constant: false
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q9H2M3
name: BHMT2
initial amount: NaN
is encoded by: hsa:23743

metaM cs e deg7 l
initial amount: NaN
constant: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
is: SBO:0000247
notes: FORMULA: C23H35O27S2 CHARGE: -3
type: Species
is: CHEBI:15936
boundary condition: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_c58d15ce_2338_42bb_9e16_7c111ef6379f
is encoded by: hsa:4715
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
is: Q9Y6M9
name: NDUFB9
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110009#_9ae777ca_091a_4a48_8579_73b214494a17
name: _AI934540_1_c
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI934540
constant: false
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_a5c47a48_aab0_4649_ae61_71bdcaf3d917
is: P36969
name: GPX4
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2879
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_4dec246f_97c0_454c_ad9b_7c3ab7f2d801
is: P15531
initial amount: NaN
has only substance units: false
name: NME1
constant: false
is encoded by: hsa:4830
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252

metaR NADtpu
is described by: ECO:0000000
product: MODEL1310110009#
fast: false
is: SBO:0000185
name: NAD transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
reversible: false
type: Reaction
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#

metaR LSTO1r
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000176
name: Lathosterol oxidase
product: MODEL1310110009#
is described by: ECO:0000269
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
fast: false
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.14.21.6

http://identifiers.org/biomodels.db/MODEL1310110009#_7447564a_c32b_4e4b_9ba5_879b74f52ae5
is: SBO:0000252
is encoded by: hsa:60481
constant: false
type: Species
name: ELOVL5
is: F6SH78
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_7bd8b19a_4079_456b_ac88_7bb775251c7f
name: HAS3
initial amount: NaN
is encoded by: hsa:3038
type: Species
is: SBO:0000252
has only substance units: false
is: O00219
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_cec7b8ea_e4f1_4592_a681_225bd0429921
is: Q13232
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4832
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
name: NME3

metaR CHSTEROLt1
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
product: MODEL1310110009#
reversible: true
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
fast: false
name: cholesterol intracellular transport
is: SBO:0000185
reactant: MODEL1310110009#

metaM c8dc c
boundary condition: false
initial amount: NaN
is: HMDB00791
initial concentration: 1.0
type: Species
notes: FORMULA: C15H26NO6 CHARGE: -1
is: C02838
name: suberyl carnitine
is: SBO:0000247
constant: false
has only substance units: false

MODEL1310110009#
species: metaM n2m2nmasn l
species: metaM biocyt m
species: metaM dgsn c
species: metaM dhlam m
species: metaM pmtcoa x
species: metaM 4nph e
species: metaM csn c
species: metaM omhpal c
species: metaM ksii core4 deg4 l
species: metaM acmanap c
species: metaM ksii core4 pre4 g
species: metaM xol7a r
species: metaM ksii core2 pre4 g
species: metaM HC01007 m
species: metaM lys L m
species: metaM ile L m
species: metaM dmhptcrn m
species: metaM tchola e
species: metaM dcsptn1 c
species: metaM 2hb c
species: metaM pro D e
species: metaM hdca r
species: metaM gthrd m
stoichiometry: 7.92
species: metaM dodecanac c
species: metaM udpacgal g
species: metaM accoa x
species: metaM c4crn e
species: metaM core6 g
species: metaM ksii core4 pre5 g
species: metaM 44mctr r
species: metaM amet m
species: metaM ddsmsterol r
species: metaM prostge1 e
species: metaM leuktrB4 c
species: metaM lnlncgcoa x
species: metaM 3hddcoa m
species: metaM ura e
species: metaM 2ddecdicoa x
stoichiometry: 0.02
species: metaM 34dhoxmand m
species: metaM udp r
species: metaM 3mgcoa m
species: metaM 2dodtricoa m
species: metaM fol c
species: metaM HC01007 x
species: metaM dcyt n
species: metaM occoa m
species: metaM doldp U r
species: metaM ksii core4 pre6 g
species: metaM na1 e
species: metaM ala D c
species: metaM ksi deg33 l
species: metaM arachcrn c
species: metaM 2hexdtetcoa x
species: metaM Rtotal3 c
species: metaM oxa m
species: metaM 7dhf m
species: metaM ksi deg10 l
species: metaM ksi deg4 l
species: metaM glyald m
species: metaM acgam r
species: metaM hdd2coa m
species: metaM rbt e
species: metaM dump m
species: metaM h n
species: metaM asn L e
species: metaM octe5coa m
species: metaM 3dhguln c
species: metaM lnlc e
species: metaM dmhptcoa m
species: metaM CE5120 m
species: metaM itacon m
species: metaM ksii core4 e
species: metaM pail5p hs c
species: metaM hexdectecoa x
species: metaM HC02121 c
species: metaM abt e
species: metaM o2s e
species: metaM k e

metaM ocdca e
has only substance units: false
is: C01530
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:25629
is: HMDB00827
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
type: Species
is: SBO:0000247
name: octadecanoate (n-C18:0)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_9f249f67_e034_4f16_a77d_0f8082fb5e61
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
name: GGT7
is: A0PJJ9
initial amount: NaN
is encoded by: hsa:2686

metaR S4TASE1ly
is: SBO:0000176
fast: false
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.12
name: N-acetylgalactosamine-4-sulfatase, lysosomal
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110009#
type: Reaction
modifier: MODEL1310110009#
product: MODEL1310110009#

metaR M1316Mg
reversible: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110009#
product: MODEL1310110009#
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
type: Reaction
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.2.1.114
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
reactant: MODEL1310110009#
fast: false

metaR KSII CORE4t
is: SBO:0000185
is described by: ECO:0000000
reversible: false
name: keratan sulfate II (core4) transport, golgi to extracellular
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110009#
fast: false
reactant: MODEL1310110009#
type: Reaction

metaR FAOXC204C205x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C20:5)x
type: Reaction

metaR FAOXC10C10OHm
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->OHC10)m
type: Reaction

metaM i c
is: CHEBI:16382
type: Species
name: iodide
has only substance units: false
initial amount: NaN
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB12238
boundary condition: false

metaM ppcoa m
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
type: Species
has only substance units: false
initial concentration: 1.0
is: C00100
is: HMDB01275
name: Propanoyl-CoA
initial amount: NaN
is: CHEBI:57392

http://identifiers.org/biomodels.db/MODEL1310110009#_c93659f3_3851_4f9d_aa08_90d3905d2b65
has only substance units: false
boundary condition: true
constant: false
is: Q15738
initial concentration: NaN
is encoded by: hsa:50814
is: SBO:0000252
name: NSDHL
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_5d24653e_fddf_4804_90a2_b2438b911569
type: Species
has only substance units: false
is encoded by: hsa:127
constant: false
is: P08319
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: ADH4

metaR SUBERCACT
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberyl carnitine into cytosol
type: Reaction

metaR FAOXC2251836m
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of fatty acid
modifier: MODEL1310110009#
reversible: false
kinetic law: MODEL1310110009#
is: SBO:0000176
fast: false
type: Reaction

metaR PAIL4P HStn
is described by: ECO:0000000
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
reversible: true
kinetic law: MODEL1310110009#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110009#
product: MODEL1310110009#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_c4ee14ce_5d35_43da_824a_fc3f494535a7
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q8TE04
is: SBO:0000252
type: Species
has only substance units: false
name: PANK1
is encoded by: hsa:53354
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_e07a84bd_4ce4_4ed1_ace6_c2310408140b
is encoded by: hsa:250
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
name: ALPP
has only substance units: false
is: P05187

http://identifiers.org/biomodels.db/MODEL1310110009#_494835c6_8c29_4221_8097_ae511adebb38
initial concentration: NaN
is: SBO:0000252
type: Species
is: O43865
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: AHCYL1
is encoded by: hsa:10768

metaM 13 cis retn c
initial amount: NaN
initial concentration: 1.0
is: HMDB06219
boundary condition: false
is: SBO:0000247
type: Species
is: D00348
name: 13-cis-retinoate
is: http://identifiers.org/pubchem.compound/7847414
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
constant: false
has only substance units: false

metaR VALt5m
reactant: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
name: Valine reversible mitochondrial transport
reversible: true
product: MODEL1310110009#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR r0909
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
product: MODEL1310110009#
reversible: true
fast: false
kinetic law: MODEL1310110009#
is: SBO:0000185
reactant: MODEL1310110009#
name: Transport reaction
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110009#_5688280c_a5be_4e93_8457_f729d47c8c5a
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
has only substance units: false
is: SBO:0000297
boundary condition: true
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:517
has part: Q06055

metaM 3octdectecoa m
is: http://identifiers.org/pubchem.compound/5280355
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
name: 3,6,9,12-octadecatetraenoylcoa
boundary condition: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4

metaM coa x
constant: false
is: C00010
is: CHEBI:57287
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
name: Coenzyme A
is: HMDB01423
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false

metaM dhf l
is: SBO:0000247
initial amount: NaN
name: dihydrofolate(2-)
is: HMDB01056
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57451
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_7ad8d283_9b17_4c34_a0ef_80f96b8baa76
boundary condition: true
name: PDE9A
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5152
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_6584d480_8585_4cf8_a562_643c16503fbc
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q53TV9
is encoded by: hsa:6120
initial amount: NaN
type: Species
name: RPE
boundary condition: true

metaR HSD11B2r
is version of: http://identifiers.org/ec-code/1.1.1.146
fast: false
name: 11-beta-hydroxysteroid dehydrogenase type 2
type: Reaction
reactant: MODEL1310110009#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3291.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
reversible: true
is: SBO:0000176
modifier: MODEL1310110009#
product: MODEL1310110009#
kinetic law: MODEL1310110009#

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaR CHSTEROLt3
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false
is: SBO:0000185
reactant: MODEL1310110009#
name: cholesterol intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR r0908
name: Postulated transport reaction
reactant: MODEL1310110009#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
product: MODEL1310110009#
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110009#

metaR r2532
fast: false
reversible: true
product: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110009#
is described by: ECO:0000000
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_082ed038_53f6_40e6_9be7_cdd76a5512ef
is: P54687
is encoded by: hsa:586
initial concentration: NaN
type: Species
initial amount: NaN
name: BCAT1
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false

metaR FAOXC102C81m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

metaR GLYC St
fast: false
name: L-glycerate export
reactant: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
reversible: false
kinetic law: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:9604805 NOTES:
is described by: ECO:0000000

metaR FK
is described by: ECO:0000000
fast: false
name: Fucokinase
kinetic law: MODEL1310110009#
product: MODEL1310110009#
is: SBO:0000176
reactant: MODEL1310110009#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.52
modifier: MODEL1310110009#
reversible: false
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD

metaR PRODt2r
is: SBO:0000185
is described by: ECO:0000304
fast: false
reactant: MODEL1310110009#
reversible: true
type: Reaction
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
modifier: MODEL1310110009#
name: D-proline reversible transport via proton symport
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_9e434936_2ac9_4da9_883e_fb1ff32e73e2
name: PDE6D
boundary condition: true
is: SBO:0000252
is: O43924
initial amount: NaN
type: Species
is encoded by: hsa:5147
constant: false
has only substance units: false
initial concentration: NaN

metaM dcdp m
constant: false
type: Species
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58593
is: HMDB01245
has only substance units: false
name: dCDP(3-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_2e9bd207_ddb9_4f51_b25a_ff26e0f766b2
initial concentration: NaN
is: Q99643
is: SBO:0000252
constant: false
type: Species
name: SDHC
has only substance units: false
is encoded by: hsa:6391
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_d7231614_f1da_4c45_8680_d4d9b868b682
constant: false
initial amount: NaN
has only substance units: false
name: IDH3B
is: SBO:0000252
is: O43837
type: Species
initial concentration: NaN
is encoded by: hsa:3420
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_733f9609_9878_4f9d_bedd_2268e7b015da
is: Q8N370
initial concentration: NaN
is encoded by: hsa:124935
boundary condition: true
is: SBO:0000252
name: SLC43A2
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaM tyr L c
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
type: Species
is: CHEBI:17895
name: L-tyrosine
boundary condition: false
initial concentration: 1.0
is: HMDB00158
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM bildglcur c
is: HMDB03325
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:58471
boundary condition: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
name: bis(beta-glucosyluronate)bilirubin
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR r2535
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
product: MODEL1310110009#

metaM dad 2 e
boundary condition: false
is: HMDB00101
initial concentration: 1.0
is: CHEBI:17256
has only substance units: false
constant: false
type: Species
name: 2-deoxyadenosine
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431

http://identifiers.org/biomodels.db/MODEL1310110009#_a91800e1_6422_48f0_8d12_83b387b19ac0
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q86YI5
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1737
name: DLAT
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_f1b1a652_cb53_4429_b59c_b3ecfe6008f0
type: Species
initial amount: NaN
has only substance units: false
is: Q6LEN6
boundary condition: true
is: SBO:0000252
constant: false
name: CHAT
initial concentration: NaN
is encoded by: hsa:1103

http://identifiers.org/biomodels.db/MODEL1310110009#_759857eb_d9da_45da_bba6_f223fcdbfd8d
name: _AI090874_1_c
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI090874
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species

metaM ksi pre31 g
is: C00130
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58053
type: Species
name: keratan sulfate I biosynthesis, precursor 31
boundary condition: false
is: HMDB00175
has only substance units: false
notes: FORMULA: C227H363N16O189S9X CHARGE: -10

http://identifiers.org/biomodels.db/MODEL1310110009#_b952566b_391b_466c_b872_9b953a8061a2
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:6647
initial concentration: NaN
boundary condition: true
name: SOD1
has only substance units: false
is: P00441
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_ed4cccf0_885a_4f2c_a02c_0c6c2c5debad
constant: false
initial amount: NaN
type: Species
name: ENTPD1
is: SBO:0000252
is encoded by: hsa:953
boundary condition: true
has only substance units: false
is: Q86VV3
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_9b514044_1d0f_4f87_bf59_72e8dc678fc1
name: ACHE
initial amount: NaN
is encoded by: hsa:43
type: Species
is: SBO:0000252
constant: false
has only substance units: false
is: P22303
boundary condition: true
initial concentration: NaN

metaM dcdp n
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: SBO:0000247
is: CHEBI:58593
has only substance units: false
name: dCDP(3-)
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB01245
type: Species

metaR RE2814M
type: Reaction
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110009#
is: SBO:0000176
name: RE2814

metaM q10 e
name: ubiquinone-10
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
constant: false
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:46245
initial concentration: 1.0
initial amount: NaN
is: HMDB01072

metaR UDPGD
reversible: false
product: MODEL1310110009#
reactant: MODEL1310110009#
name: UDPglucose 6-dehydrogenase
fast: false
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.22
is described by: ECO:0000304
type: Reaction
is: SBO:0000176
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (7358.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 1.1.1.22 Confidence Level: 2 AUTHORS: PMID:9296457,PMID:9737970 NOTES:JLR

metaR DURAD2
name: dihydrothymin dehydrogenase (NADP)
is: SBO:0000176
fast: false
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
type: Reaction
product: MODEL1310110009#
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.1.2
reactant: MODEL1310110009#

metaR THRALANaEx
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-alanine/L-threonine Na-dependent exchange (Thr-L in)
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reversible: false
is: SBO:0000185
fast: false

metaR r2534
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
product: MODEL1310110009#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
fast: false
type: Reaction
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110009#_a6c7579a_5b48_488d_ae39_4d4ab9b1de57
initial amount: NaN
is encoded by: hsa:27068
type: Species
initial concentration: NaN
is: Q9H2U2
boundary condition: true
name: PPA2
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_74c9c14b_b3a0_4ca8_affc_f9d63b86b799
name: PDE9A
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5152
is: SBO:0000252
type: Species
constant: false

metaM mercplac c
type: Species
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
is: http://identifiers.org/pubchem.compound/8118
is: C05823
name: 3-Mercaptolactate
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB02127

metaR LEUKTRE4t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
fast: false
product: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
name: leukotriene E4 transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110009#_67bc38bc_8a42_44c5_9aba_3129807145d3
is encoded by: hsa:515
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: ATP5F1
type: Species
constant: false
is: SBO:0000252
has only substance units: false

metaR PROSTGE1t
name: prostaglandin transport via bicarbonate countertransport
type: Reaction
kinetic law: MODEL1310110009#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
product: MODEL1310110009#
reactant: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000185
fast: false
reversible: true

metaM tyr L e
name: L-tyrosine
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: CHEBI:17895
is: HMDB00158
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false

metaR r2537
product: MODEL1310110009#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110009#
is described by: ECO:0000000
name: Utilized transport
kinetic law: MODEL1310110009#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false

metaM dad 2 c
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
initial concentration: 1.0
is: HMDB00101
boundary condition: false
has only substance units: false
name: 2-deoxyadenosine
is: CHEBI:17256

metaR RE2985X
name: RE2985
is: SBO:0000176
type: Reaction
product: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.17.99.3
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (8310.1) or (8309.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110009#
reversible: false
fast: false

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaR RE0691C
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
reactant: MODEL1310110009#
name: RE0691
kinetic law: MODEL1310110009#
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110009#
reversible: true

metaM dgmp c
is: C00362
is: CHEBI:57673
constant: false
has only substance units: false
initial amount: NaN
name: dGMP
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB01044
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362

metaR SARCStm
is: SBO:0000185
type: Reaction
name: Sarcosine transport (mitochondrial)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
kinetic law: MODEL1310110009#
reversible: false
reactant: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_9b5ec924_1ae0_4df1_9eb5_f2193a5972a2
is encoded by: hsa:1327
initial concentration: NaN
is encoded by: hsa:1339
is encoded by: hsa:1340
is encoded by: hsa:1345
is encoded by: hsa:341947
is encoded by: hsa:9167
has part: Q8TF08
is encoded by: hsa:1337
has part: Q7GXY8
constant: false
is: SBO:0000297
has part: P15954
has only substance units: false
has part: P24311
has part: Q7Z4L0
initial amount: NaN
is encoded by: hsa:1349
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: P14854
is encoded by: hsa:4513
is encoded by: hsa:1346
type: Species
has part: Q53YB7
has part: H0UI06
has part: P00414
is encoded by: hsa:9377
boundary condition: true
has part: Q96KJ9
has part: Q02221
is encoded by: hsa:1347
is encoded by: hsa:1350
is encoded by: hsa:170712
has part: P24310
is encoded by: hsa:4514
is encoded by: hsa:1329
has part: P13073
has part: P12074
is encoded by: hsa:4512
has part: Q6FGA0
is encoded by: hsa:1351
is encoded by: hsa:125965
has part: Q6YFQ2
has part: P09669
has part: Q53XN1
has part: P20674
has part: Q7GXZ8
is encoded by: hsa:84701

metaR PRGSTRNt
name: Progesterone transport
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110009#
product: MODEL1310110009#
kinetic law: MODEL1310110009#
fast: false

metaR FAOXC102C103m
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaM ptdcacoa m
boundary condition: false
has only substance units: false
type: Species
constant: false
name: pentadecanoyl Coenzyme A
initial concentration: 1.0
is: SBO:0000247
is: HMDB06499
initial amount: NaN
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110009#_8e3c7e88_751d_4ff3_a7ab_f5ef13d32aee
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is encoded by: hsa:8897
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: MTMR3
is: Q13615

http://identifiers.org/biomodels.db/MODEL1310110009#_80a959cb_b4f8_4b86_a137_f9914f41c031
has only substance units: false
is encoded by: hsa:1629
initial amount: NaN
is: P11182
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: DBT
constant: false

metaR C4STMO1r
modifier: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
reversible: false
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000176
type: Reaction
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.72
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ

metaM q10 c
is: HMDB01072
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
type: Species
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
name: ubiquinone-10
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:46245

http://identifiers.org/biomodels.db/MODEL1310110009#_fb3183fa_22ba_4331_9c9a_3285f1788b9c
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:11254
name: SLC6A14
type: Species
initial amount: NaN
is: Q9UN76

metaR DNDPt35m
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
modifier: MODEL1310110009#
name: dGDP transport via dADP antiport
type: Reaction
fast: false
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_34206a7e_59eb_4040_8d02_d9185c3934c2
is: Q9P0Z9
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
name: PIPOX
has only substance units: false
type: Species
is encoded by: hsa:51268

metaR ABUTD
modifier: MODEL1310110009#
product: MODEL1310110009#
is described by: ECO:0000269
reversible: false
name: Aminobutyraldehyde dehydrogenase
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
kinetic law: MODEL1310110009#
is: SBO:0000176

metaR LINKDEG4ly
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110009#
is: SBO:0000176
name: degradation of proteoglycan linkage region, lysosomal
is described by: ECO:0000000
product: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD

metaM coa n
is: HMDB01423
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
name: coenzyme A(4-)
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_29518765_349f_48d8_920a_56bae717bca2
initial concentration: NaN
type: Species
name: AGXT2
boundary condition: true
is encoded by: hsa:64902
constant: false
is: Q9BYV1
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR Htx
is described by: ECO:0000000
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
fast: false
name: H transporter, peroxisome
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#

metaM lnlncg r
constant: false
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB03073
is: CHEBI:32391
name: gamma-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
initial amount: NaN

metaR RE2814R
reversible: true
type: Reaction
name: RE2814
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
is: SBO:0000176

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaM ksi pre26 g
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
name: keratan sulfate I biosynthesis, precursor 26
is: CHEBI:28067
initial amount: NaN
constant: false
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_4352af09_d494_4660_b50c_9970a5f65135
is encoded by: hsa:5151
name: PDE8A
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true

metaM CE2417 m
has only substance units: false
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
is: SBO:0000247
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
initial amount: NaN
constant: false
is: HMDB11123
is: CHEBI:28387
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110009#_185230b4_0112_417b_94ed_5ffd42221479
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: Q96RV2
has only substance units: false
is encoded by: hsa:3038
is: SBO:0000252
name: HAS3
constant: false

metaM pan4p e
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: HMDB01416
is: CHEBI:47942
initial amount: NaN
constant: false
is: C01134
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
name: Pantetheine 4'-phosphate

metaM coa m
is: C00010
boundary condition: false
has only substance units: false
is: CHEBI:57287
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: HMDB01423
name: Coenzyme A

metaR RE0383C
reversible: true
product: MODEL1310110009#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
name: RE0383
is: SBO:0000176

metaR FATP6t
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.7
modifier: MODEL1310110009#
name: fatty acid electroneutral transport
type: Reaction
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000185
product: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaR r0627
is: SBO:0000176
product: MODEL1310110009#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23

metaR RE3243R
is: SBO:0000176
reversible: true
reactant: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110009#
type: Reaction
modifier: MODEL1310110009#
product: MODEL1310110009#
name: RE3243

metaR H3MTer L
kinetic law: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
name: H3 mannosyltransferase, endoplasmic reticulum
fast: false
modifier: MODEL1310110009#
reactant: MODEL1310110009#
reversible: false
type: Reaction

metaR 5MTHFt
reactant: MODEL1310110009#
is: SBO:0000185
product: MODEL1310110009#
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
modifier: MODEL1310110009#
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
reversible: true

metaM xyl D c
has only substance units: false
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
name: aldehydo-D-xylose
is: CHEBI:15936

http://identifiers.org/biomodels.db/MODEL1310110009#_663655c7_ea32_48f0_8bd9_c876ff842e2c
is encoded by: hsa:57835
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
name: SLC4A5

http://identifiers.org/biomodels.db/MODEL1310110009#_1d66feec_ae08_42df_8ad8_865dd53aec17
name: DGAT1
has only substance units: false
constant: false
boundary condition: true
is: O75907
is: SBO:0000252
is encoded by: hsa:8694
initial concentration: NaN
type: Species
initial amount: NaN

metaM hs deg21 l
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
initial amount: NaN
boundary condition: false
notes: FORMULA: C37H55NO38S2 CHARGE: -4
is: CHEBI:16126
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_bf4b0174_914e_4be9_a84a_167419528378
constant: false
has only substance units: false
type: Species
boundary condition: true
name: INPP5J
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:27124

http://identifiers.org/biomodels.db/MODEL1310110009#_7d69331e_efa3_4d2a_9d08_f1e0d5297c3c
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5152
constant: false
name: PDE9A
is: SBO:0000252
has only substance units: false
type: Species

metaR 41R2A1H12BOOX
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.4.3.4
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
reversible: false
fast: false
name: 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)

metaR ADA
is: SBO:0000176
fast: false
product: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.4.4
name: Adenosine deaminase
reversible: false
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR

metaM bildglcur e
initial concentration: 1.0
is: CHEBI:58471
constant: false
is: HMDB03325
boundary condition: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
name: bis(beta-glucosyluronate)bilirubin

http://identifiers.org/biomodels.db/MODEL1310110009#_b65f83d6_d29b_44c5_9ec9_ec787cca2b95
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
name: FASN
initial amount: NaN
initial concentration: NaN
is: P49327
is encoded by: hsa:2194
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_27e27caf_9bd3_4935_91d7_fbf869452b4e
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:23057
constant: false
name: NMNAT2
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_45c6d6b2_bd29_4e85_b51a_c101bacbf743
constant: false
is: SBO:0000252
is: P28330
name: ACADL
has only substance units: false
is encoded by: hsa:33
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN

metaM dhf c
has only substance units: false
initial concentration: 1.0
is: HMDB01056
is: SBO:0000247
initial amount: NaN
is: C00415
type: Species
constant: false
is: CHEBI:57451
name: 7,8-Dihydrofolate
boundary condition: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415

http://identifiers.org/biomodels.db/MODEL1310110009#_0469fb7f_1298_48e5_97d3_4d715f49b092
boundary condition: true
has only substance units: false
is: P19801
initial concentration: NaN
is encoded by: hsa:26
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
name: ABP1

metaM pan4p c
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:47942
is: HMDB01416
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
name: Pantetheine 4'-phosphate
is: C01134
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134

metaR r0629
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110009#
modifier: MODEL1310110009#
reactant: MODEL1310110009#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
reversible: true
fast: false
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.22
is version of: http://identifiers.org/ec-code/3.1.4.1

http://identifiers.org/biomodels.db/MODEL1310110009#_fcd3d61d_8b69_45c0_92d6_cf6098496721
initial concentration: NaN
is encoded by: hsa:23057
has only substance units: false
name: NMNAT2
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: Q9BZQ4
is: SBO:0000252

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

metaM ppi e
initial amount: NaN
has only substance units: false
is: HMDB00250
boundary condition: false
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: C00013
name: Diphosphate
constant: false
is: CHEBI:33019
is: SBO:0000247
initial concentration: 1.0

metaM cys L e
initial amount: NaN
is: HMDB00574
constant: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: SBO:0000247
has only substance units: false
name: L-cysteine
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:17561

metaR HSAT4ly
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
product: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
name: heparan-glucosaminide N-acetyltransferase, lysosomal

metaM ksi pre7 g
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:58053
is: C00130
is: HMDB00175
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 7
constant: false
notes: FORMULA: C115H187N8O85SX CHARGE: -2
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110009#_7a59845b_44ef_40d5_bb13_bedf6679c61f
has only substance units: false
initial concentration: NaN
is: Q6LEN5
is: SBO:0000252
is encoded by: hsa:1103
name: CHAT
constant: false
initial amount: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_15ccd591_7a1f_4e0a_823a_fb1fde2e7db6
is: Q9Y5B8
constant: false
initial concentration: NaN
has only substance units: false
name: NME7
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:29922

metaM hx2coa m
type: Species
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
constant: false
is: http://identifiers.org/pubchem.compound/11966188
name: trans-Hex-2-enoyl-CoA
is: HMDB06870
boundary condition: false
initial concentration: 1.0
is: C05998
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR r2133
reactant: MODEL1310110009#
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110009#
is: SBO:0000185
modifier: MODEL1310110009#
reversible: true
product: MODEL1310110009#

metaM ppcoa c
name: Propanoyl-CoA
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
constant: false
is: C00100
is: SBO:0000247
is: CHEBI:57392
type: Species
is: HMDB01275

metaR DHFtl
type: Reaction
reversible: true
product: MODEL1310110009#
name: dihydrofolate reversible lysosomal transport
kinetic law: MODEL1310110009#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD,IT
is described by: ECO:0000000
reactant: MODEL1310110009#

metaM coa r
initial concentration: 1.0
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
boundary condition: false
name: Coenzyme A
constant: false
is: SBO:0000247
is: HMDB01423
is: CHEBI:57287
has only substance units: false
is: C00010
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_92cf72a5_ed0e_4d84_bddc_266023ca6cd7
constant: false
has only substance units: false
is: Q9NWU1
is encoded by: hsa:54995
initial amount: NaN
name: OXSM
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaM xyl D e
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
type: Species
is: SBO:0000247
is: CHEBI:15936
name: aldehydo-D-xylose
boundary condition: false
initial concentration: 1.0

metaM ksi deg33 l
has only substance units: false
is: CHEBI:12936
initial concentration: 1.0
boundary condition: false
name: keratan sulfate I, degradation product 33
is: SBO:0000247
constant: false
is: HMDB00143
type: Species
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
initial amount: NaN

metaM HC01406 m
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
name: 3-Oxooctanoyl-CoA
is: SBO:0000247
is: CHEBI:28264
constant: false
type: Species
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267

http://identifiers.org/biomodels.db/MODEL1310110009#_13b459d0_e4a7_4d1d_ba4c_c986dae17ad1
initial concentration: NaN
name: SDHA
is: P31040
boundary condition: true
initial amount: NaN
is encoded by: hsa:6389
has only substance units: false
is: SBO:0000252
constant: false
type: Species

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaR MALTe
kinetic law: MODEL1310110009#
name: alpha-glucosidase, extracellular
is version of: http://identifiers.org/ec-code/3.2.1.20
is described by: ECO:0000269
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8972.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:3143729 NOTES:IF
product: MODEL1310110009#
fast: false
modifier: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction

metaM uacgam c
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
type: Species
is: SBO:0000247
is: CHEBI:57705
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00290
constant: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)

metaR GALtly
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
reversible: false
name: galactose efflux from lysosome
reactant: MODEL1310110009#
product: MODEL1310110009#

metaM ppi c
type: Species
notes: FORMULA: HO7P2 CHARGE: -3
name: Diphosphate
is: SBO:0000247
initial amount: NaN
constant: false
is: C00013
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:0
is: HMDB00250

metaM 1pipdn2c x
name: 1-piperideine-2-carboxylate
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
type: Species
has only substance units: false
is: HMDB01084
is: CHEBI:16187
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR r2132
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110009#
is: SBO:0000185
reactant: MODEL1310110009#
type: Reaction
modifier: MODEL1310110009#
is described by: ECO:0000000
kinetic law: MODEL1310110009#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r1147
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR FAOXC102C103x
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_b11ffdc7_d464_4458_95fc_2a133599247a
type: Species
initial amount: NaN
has only substance units: false
name: GGT7
is: SBO:0000252
is encoded by: hsa:2686
constant: false
boundary condition: true
initial concentration: NaN
is: A0PJJ9

metaM hs deg3 l
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: heparan sulfate, degradation product 3
has only substance units: false
constant: false
is: CHEBI:16126
initial amount: NaN
type: Species
notes: FORMULA: C81H117N5O97S10 CHARGE: -12

http://identifiers.org/biomodels.db/MODEL1310110009#_953a77d6_5aa8_4c59_ab86_5589af2d69d9
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:4707
name: NDUFB1
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: O75438
constant: false

metaM q10 m
constant: false
has only substance units: false
type: Species
is: HMDB01072
is: CHEBI:46245
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
initial concentration: 1.0
initial amount: NaN
name: ubiquinone-10
boundary condition: false
is: SBO:0000247

metaM cys L c
initial amount: NaN
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
initial concentration: 1.0
is: HMDB00574
name: L-cysteine
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:17561
is: SBO:0000247
constant: false

metaR RADH4
is: SBO:0000176
reversible: true
product: MODEL1310110009#
name: retinal dehydrogenase (NADPH)
reactant: MODEL1310110009#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:11606944 NOTES:IT
kinetic law: MODEL1310110009#
fast: false
type: Reaction

metaR DOLPH Uer
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
name: Dolichol-phosphate phosphohydrolase, human (uterus)
reversible: false
product: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110009#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_e1d7cb39_44dd_49c5_97f4_00323ba9b438
initial amount: NaN
boundary condition: true
is encoded by: hsa:6342
is: SBO:0000252
initial concentration: NaN
is: C9JC79
constant: false
name: SCP2
has only substance units: false
type: Species

metaR r1148
name: Active transport
fast: false
product: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
reversible: true
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
is: SBO:0000185

metaR C30CPT1
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of propionylcarnitine
type: Reaction

metaR GDPtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
name: GDP intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110009#_f76639f4_f28d_4eec_a28b_dbf4c385310d
type: Species
name: DPM3
has only substance units: false
boundary condition: true
is encoded by: hsa:54344
is: SBO:0000252
is: Q86TM7
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_bb1501bd_d09c_4f57_8f1c_cfd736353e78
boundary condition: true
initial amount: NaN
is: O14975
name: SLC27A2
type: Species
is encoded by: hsa:11001
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_cd938384_60df_4c3f_8e6f_93d8590e11ca
has only substance units: false
name: COASY
initial amount: NaN
type: Species
is: SBO:0000252
is: Q13057
is encoded by: hsa:80347
boundary condition: true
constant: false
initial concentration: NaN

metaR PSDm hs
modifier: MODEL1310110009#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.65
reactant: MODEL1310110009#
is described by: ECO:0000269
product: MODEL1310110009#
reversible: false
kinetic law: MODEL1310110009#
name: Phosphatidylserine decarboxylase
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
is: SBO:0000176

metaR THRGLNexR
is described by: ECO:0000304
name: L-threonine/glycine reversible exchange
reactant: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110009#
fast: false
type: Reaction
product: MODEL1310110009#
reversible: true
modifier: MODEL1310110009#

metaR MERCPLACCYSt
is described by: ECO:0000000
type: Reaction
product: MODEL1310110009#
reversible: false
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
fast: false
name: 3-mercaptolactate-cysteine disulfide transport, extracellular
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_82ff7c59_58e9_43db_be1d_245b98fb0cbe
name: ACOT4
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:122970
is: Q8N9L9

http://identifiers.org/biomodels.db/MODEL1310110009#_f0c9d84c_3950_4561_b7d4_d551f582e4be
is encoded by: hsa:389015
name: SLC9A4
is: Q6AI14
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN

metaR r2130
reversible: true
product: MODEL1310110009#
modifier: MODEL1310110009#
is: SBO:0000185
reactant: MODEL1310110009#
type: Reaction
kinetic law: MODEL1310110009#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000

metaR DHFtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
kinetic law: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110009#
type: Reaction
fast: false
reversible: true
product: MODEL1310110009#
name: dihydrofolate reversible mitochondrial transport

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR GUAPRT
is version of: http://identifiers.org/ec-code/2.4.2.8
fast: false
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
product: MODEL1310110009#
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000269
reversible: false
name: guanine phosphoribosyltransferase
type: Reaction

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaM 3octdectecoa x
is: http://identifiers.org/pubchem.compound/5280355
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: 3,6,9,12-octadecatetraenoylcoa
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
type: Species

metaM doco13ecoa x
constant: false
initial amount: NaN
type: Species
name: 13-docosenoylcoa
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892791

metaM g1m8mpdol U r
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: CHEBI:59093
constant: false
notes: FORMULA: C1785H2940N20O670P20 CHARGE: -20

metaR r0845
is: SBO:0000185
reversible: false
reactant: MODEL1310110009#
name: Drug/Metabolite Transporter (DMT) TCDB:2.A.7.12.7
fast: false
product: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12759756,PMID:17466261,PMID:9759482 NOTES:UGLCNACtg but different compartment
kinetic law: MODEL1310110009#

metaR SUCCACT
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of succinate
type: Reaction

metaR Coqe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000134
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
name: Transport of q10
reversible: true
type: Reaction
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_a68fce95_2be4_4082_b928_eae318fe6393
is: SBO:0000252
is encoded by: hsa:AV717590
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
name: _AV717590_1_m
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_0cac1d7d_5c46_40f7_914a_6c3e0b45bc18
has only substance units: false
name: ITPKB
is encoded by: hsa:3707
initial concentration: NaN
is: P27987
constant: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM pan4p m
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01416
name: pantetheine 4'-phosphate(2-)
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: CHEBI:47942
constant: false

metaR EX c5dc
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glutaryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_c608c14a_699d_4ff9_a3f0_7251d10d0ed7
name: ST3GAL3
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6487
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_8b9f70ac_417d_4e65_9db2_36f76f9b2af0
initial amount: NaN
boundary condition: true
is encoded by: hsa:AA021081
initial concentration: NaN
name: _AA021081_1_r
has only substance units: false
constant: false
type: Species
is: SBO:0000252

metaR r2136
product: MODEL1310110009#
modifier: MODEL1310110009#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
reactant: MODEL1310110009#
reversible: false
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_24739f4d_f26d_41f0_93c3_c1889ed9f7f8
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: O95299
is: SBO:0000252
name: NDUFA10
constant: false
is encoded by: hsa:4705
boundary condition: true

metaR PUNP6
is: SBO:0000176
reversible: true
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
modifier: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Deoxyinosine)
product: MODEL1310110009#
kinetic law: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_f2f1a680_9c59_4fde_bcc3_24f74c3e3617
type: Species
is encoded by: hsa:211
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
name: ALAS1
is: Q5JAM2
initial concentration: NaN
initial amount: NaN

metaR ITPtn
type: Reaction
kinetic law: MODEL1310110009#
is described by: ECO:0000000
fast: false
product: MODEL1310110009#
is: SBO:0000185
reversible: true
name: ITP nuclear transport
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110009#_e428f781_4263_404b_b7fc_61562ba87b23
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: SLC12A4
boundary condition: true
is encoded by: hsa:6560
constant: false
is: F5H066
initial concentration: NaN
type: Species

metaM CE2421 m
name: (3S)-3-hydroxylinoleoyl-CoA
has only substance units: false
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:30623
constant: false
type: Species
is: SBO:0000247
is: HMDB02329

metaM uacgam g
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: HMDB00290
initial amount: NaN
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
initial concentration: 1.0
is: CHEBI:57705
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_90c78607_e49c_44bd_a8a2_abdef3426b38
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:84720
name: PIGF:PIGO
is encoded by: hsa:5281
constant: false
is: SBO:0000297
type: Species
has part: Q6IB04
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_58600a01_495e_4f2e_abe1_5a77456b3dd3
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
is: Q9HCC0
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:64087
name: MCCC2

metaR ACCOAgt
name: acetyl-coa transport
product: MODEL1310110009#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
kinetic law: MODEL1310110009#
reversible: true
is: SBO:0000185
reactant: MODEL1310110009#
type: Reaction

MODEL1310110009
reaction: metaR r2094
reaction: metaR MTHFD
reaction: metaR EX glysar LPAREN e RPAREN
reaction: metaR RE0383C
reaction: metaR HSD11B1r
reaction: metaR EX fmn LPAREN e RPAREN
reaction: metaR r0591
reaction: metaR r1552
species: metaM 4abutn c
reaction: metaR r2532
reaction: metaR r0345
species: metaM ksi pre3 g
reaction: metaR DHCR243r
species: metaM crtsl r
reaction: metaR MALTe
species: metaM hdcea r
species: metaM pristcoa x
reaction: metaR PCRNtc
reaction: metaR LGTHL
reaction: metaR FUMAC
species: metaM arachcoa c
reaction: metaR APRGSTRNte
reaction: metaR GLCt4
species: metaM trp L e
species: metaM tdcoa m
reaction: metaR GALtly
species: metaM ksi l
reaction: metaR r0354
reaction: metaR r0084
reaction: metaR FRUt4
species: metaM gdp e
reaction: metaR EX c5dc
reaction: metaR r2101
reaction: metaR CMPSAS
species: metaM accoa r
reaction: metaR ACCOAtn
reaction: metaR EX retinol LPAREN e RPAREN
species: metaM sbt D c
reaction: metaR r0068
species: metaM 4abut c
species: metaM lac D e
reaction: metaR EX doco13ac
reaction: metaR r1610
reaction: metaR FAOXC225C204m
reaction: metaR G13MT U
species: metaM akg e
species: metaM C05280 m
reaction: metaR FAOXC11
species: metaM ppi c
reaction: metaR PPAm
species: metaM dhdascb e
reaction: metaR EX glygn5 LPAREN e RPAREN
species: metaM 3hbcoa m
species: metaM c226coa c
species: metaM dgtp c
species: metaM 3hdcoa m
reaction: metaR GLYC St
reaction: metaR EX dopasf LPAREN e RPAREN
reaction: metaR r0722
reaction: metaR ALDD2x
species: metaM dhap e
species: metaM bilglcur c
species: metaM gthox m
reaction: metaR SAMHISTA
species: metaM mma c
species: metaM dudp n
species: metaM ddcacoa c
reaction: metaR 2AMADPTm
species: metaM HC02216 c
reaction: metaR RE3627M
reaction: metaR sink pre prot LPAREN r RPAREN
reaction: metaR C51CPT1
species: metaM 3hexdtricoa m
reaction: metaR UMPK3n
reaction: metaR r1573
reaction: metaR IVCRNe
reaction: metaR CYStec
reaction: metaR RE2814R
reaction: metaR r1620
species: metaM arach e

metaR PUNP4
name: purine-nucleoside phosphorylase (Deoxyguanosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
kinetic law: MODEL1310110009#
reversible: true
is: SBO:0000176
modifier: MODEL1310110009#
fast: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110009#

metaM m2mn l
boundary condition: false
type: Species
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
constant: false
initial concentration: 1.0
is: HMDB06537
has only substance units: false

metaR PUNP5
fast: false
product: MODEL1310110009#
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
is described by: ECO:0000269
is: SBO:0000176
reversible: true
name: purine-nucleoside phosphorylase (Inosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
reactant: MODEL1310110009#

metaM pydx c
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
initial concentration: 1.0
constant: false
is: C00250
boundary condition: false
is: HMDB01545
initial amount: NaN
name: Pyridoxal
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:17310

metaR r2137
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
type: Reaction
modifier: MODEL1310110009#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
reversible: true
reactant: MODEL1310110009#
fast: false
kinetic law: MODEL1310110009#
is: SBO:0000185
product: MODEL1310110009#

http://identifiers.org/biomodels.db/MODEL1310110009#_b4fa7628_c47f_4ac0_b323_406ea16308af
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3421
constant: false
has part: P51553
has only substance units: false
has part: O43837
is encoded by: hsa:3420
is: SBO:0000297
initial amount: NaN
name: IDH3A:IDH3B:IDH3G

metaR LEUPHELAT2tc
kinetic law: MODEL1310110009#
product: MODEL1310110009#
reactant: MODEL1310110009#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM dc2coa x
is: SBO:0000247
name: trans-Dec-2-enoyl-CoA
has only substance units: false
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: HMDB01168
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4

metaR PIK3
is version of: http://identifiers.org/ec-code/2.7.1.137
is version of: http://identifiers.org/ec-code/2.7.1.154
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#
product: MODEL1310110009#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
name: phosphatidylinositol 3-kinase

metaM g2m8masn r
is: SBO:0000247
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
initial concentration: 1.0
constant: false
is: C05874
boundary condition: false
has only substance units: false
notes: FORMULA: C82H137N2O65X CHARGE: 0
initial amount: NaN

metaM ksi deg26 l
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00061
is: CHEBI:58343
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
initial concentration: 1.0
name: keratan sulfate I, degradation product 26
type: Species
initial amount: NaN

metaM ppi n
is: SBO:0000247
name: diphosphate(3-)
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:33019
constant: false
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
initial amount: NaN

metaM fadh2 x
has only substance units: false
initial amount: NaN
is: HMDB01197
constant: false
type: Species
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
name: FADH2(2-)
is: SBO:0000247
is: CHEBI:58307
boundary condition: false
initial concentration: 1.0

metaR PUNP3
reactant: MODEL1310110009#
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
fast: false
product: MODEL1310110009#
is described by: ECO:0000269
kinetic law: MODEL1310110009#
reversible: true
is: SBO:0000176
type: Reaction
name: purine-nucleoside phosphorylase (Guanosine)

metaR PHEt4
fast: false
name: L-phenylalanine transport in via sodium symport
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (54407.1) or (84889.1) or (11254.1) or (6542.1) or (81539.1) or (6541.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
reversible: false
kinetic law: MODEL1310110009#
modifier: MODEL1310110009#

metaM HC01444 e
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:15754
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
has only substance units: false
boundary condition: false
is: SBO:0000247
name: Galactosylglycerol

metaR r0085
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
reversible: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110009#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110009#
product: MODEL1310110009#
modifier: MODEL1310110009#

metaM hgentis c
name: homogentisate
is: HMDB00130
boundary condition: false
constant: false
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16169

metaM ppi m
name: Diphosphate
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: CHEBI:33019
constant: false
is: HMDB00250
is: C00013

metaR DCSPTN1t
kinetic law: MODEL1310110009#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
fast: false
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110009#_2ed9bb42_c1c4_4510_b4cf_97c95f6a3b06
name: GCK
is: P35557
is encoded by: hsa:2645
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaM dcdp c
boundary condition: false
name: dCDP
type: Species
is: C00705
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial concentration: 1.0
is: HMDB01245
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:58593
constant: false

metaR PUNP2
kinetic law: MODEL1310110009#
name: purine-nucleoside phosphorylase (Deoxyadenosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
modifier: MODEL1310110009#
reversible: true
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110009#
reactant: MODEL1310110009#

metaR GALASE13ly
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110009#
reversible: false
kinetic law: MODEL1310110009#
is: SBO:0000176
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
product: MODEL1310110009#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110009#_cfe09182_2792_49e9_9c68_cc6a70291ec1
constant: false
is encoded by: hsa:10599
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q9Y6L6
is: SBO:0000252
name: SLCO1B1
initial amount: NaN
type: Species

metaM pydx e
is: SBO:0000247
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: Pyridoxal
constant: false
has only substance units: false
is: C00250
is: CHEBI:17310
is: HMDB01545

metaR O2tp
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110009#
is: SBO:0000185
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
name: O2 transport, peroxisomal
reversible: true

metaR r0086
kinetic law: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
fast: false
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.3
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110009#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110009#_5883173a_ad64_495b_aeb5_ca7676e64f51
is: Q9HAY6
name: BCMO1
is: SBO:0000252
constant: false
is encoded by: hsa:53630
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110009#_50dec8ab_4b77_4736_8a46_18ea4515cf72
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
name: SLCO2A1
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6578
is: Q92959
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_56774e82_516e_4855_92f0_f5e93372acfd
has only substance units: false
constant: false
name: PLCL1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5334
initial concentration: NaN
boundary condition: true
type: Species
is: Q15111

metaR RE1810M
is: SBO:0000176
is described by: ECO:0000000
name: RE1810
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
product: MODEL1310110009#

metaR RE2625C
type: Reaction
name: RE2625
is described by: ECO:0000000
product: MODEL1310110009#
reactant: MODEL1310110009#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false
kinetic law: MODEL1310110009#
is: SBO:0000176

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaR EX hpdca LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptadecanoate exchange
type: Reaction

metaM ksii core4 pre6 g
has only substance units: false
notes: FORMULA: C69H111N6O51SX CHARGE: -2
type: Species
constant: false
initial amount: NaN
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 6
is: SBO:0000247
is: CHEBI:28067
initial concentration: 1.0

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaR r0841
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.271
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
reversible: true
is: SBO:0000185
reactant: MODEL1310110009#
name: Free diffusion
product: MODEL1310110009#
kinetic law: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110009#

metaR CHATn
name: Choline O-acetyltransferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.6
fast: false
reversible: true
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
is described by: ECO:0000269
modifier: MODEL1310110009#

metaM dhbpt c
name: 6,7-dihydrobiopterin
constant: false
type: Species
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
initial amount: NaN
is: HMDB00038
initial concentration: 1.0
has only substance units: false
is: CHEBI:20680
is: SBO:0000247

metaR NACHEX12ly
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110009#
is described by: ECO:0000000
reactant: MODEL1310110009#
modifier: MODEL1310110009#
fast: false
type: Reaction
product: MODEL1310110009#
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110009#_445844f6_1c48_418b_8d3f_7101f6fac424
boundary condition: true
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:2876
has only substance units: false
initial amount: NaN
name: GPX1
initial concentration: NaN

metaM 3hdcoa m
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
name: (S)-3-Hydroxydecanoyl-CoA
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/16019966

metaR SERtN1
modifier: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
reversible: true
reactant: MODEL1310110009#
fast: false
product: MODEL1310110009#
kinetic law: MODEL1310110009#
is: SBO:0000185
is described by: ECO:0000269
name: Serine transport (Na, H coupled)

metaR r1365
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110009#
name: Vesicular transport
reactant: MODEL1310110009#
product: MODEL1310110009#
reversible: false

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaM 4hexdtetcoa x
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB02288
constant: false
name: 4,7,10,13-hexadecatetraenoylcoa
boundary condition: false
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110009#_a5daa70a_3a47_4ac9_908a_ecbe0acb8ec8
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: PLCE1
is: Q9P212
is encoded by: hsa:51196
boundary condition: true

metaR r0083
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
reactant: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
fast: false
reversible: true
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
type: Reaction
modifier: MODEL1310110009#

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_1f072a0b_54bc_40a3_95e1_85a666d74c28
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
name: ALDH3A1
boundary condition: true
is encoded by: hsa:218
initial concentration: NaN
is: P30838
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110009#_7ec53ad2_9b16_4522_a503_144828ea4f98
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
name: _BE966236_1_m
is encoded by: hsa:BE966236

metaR r0842
type: Reaction
is described by: ECO:0000000
product: MODEL1310110009#
is: SBO:0000185
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
reactant: MODEL1310110009#
reversible: true
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/1.3.1.72
fast: false
name: Postulated transport reaction

http://identifiers.org/biomodels.db/MODEL1310110009#_84ef890e_fba9_4fb9_82b3_fd9718ec9309
initial amount: NaN
is: SBO:0000252
name: GLUL
is: P15104
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:2752
constant: false

http://identifiers.org/biomodels.db/MODEL1310110009#_d3c3c1d4_12b2_4407_bf90_9a65771aef7b
has only substance units: false
name: PGAP1
is: SBO:0000252
is: Q75T13
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:80055
boundary condition: true

metaR r1259
product: MODEL1310110009#
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110009#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: EC:6.2.1.3
is: SBO:0000176
kinetic law: MODEL1310110009#

metaR r0084
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110009#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110009#
is described by: ECO:0000000
product: MODEL1310110009#
modifier: MODEL1310110009#
reversible: true

metaM pristcoa c
is: CHEBI:51341
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
name: pristanoyl coa

metaM cytd e
constant: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
has only substance units: false
is: CHEBI:17562
initial concentration: 1.0
is: HMDB00089
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: Cytidine
type: Species
is: C00475

metaR r1364
reactant: MODEL1310110009#
product: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
name: Vesicular transport
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110009#
is: SBO:0000185

metaR O2tn
type: Reaction
name: O2 nuclear transport
product: MODEL1310110009#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110009#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110009#
reversible: true

metaM m4mpdol U c
is: CHEBI:37633
has only substance units: false
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
boundary condition: false

metaM dec24dicoa m
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB01168
initial concentration: 1.0
has only substance units: false
name: 2,4-decadienoylcoa

metaR ACNAMlt
type: Reaction
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
product: MODEL1310110009#
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
is: SBO:0000185
is described by: ECO:0000269
name: N-acetylneuraminate transport into lysososme
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110009#_2f0e041a_6e4f_4f65_8f9f_ae439d26d62f
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:AA203143
boundary condition: true
type: Species
has only substance units: false
name: _AA203143_1_c
initial concentration: NaN

metaR O2tm
reactant: MODEL1310110009#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
kinetic law: MODEL1310110009#
fast: false
reversible: true
type: Reaction
product: MODEL1310110009#
is described by: ECO:0000000
is: SBO:0000185
name: O2 transport (diffusion)

metaM ksii core2 pre3 g
is: C00130
name: keratan sulfate II biosynthesis, precursor 3
is: HMDB00175
is: SBO:0000247
notes: FORMULA: C47H76N4O33X CHARGE: -1
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:58053
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_dc7def60_ec95_4166_9c47_b8ddedc6b8c3
initial amount: NaN
is encoded by: hsa:218
initial concentration: NaN
constant: false
is: SBO:0000252
name: ALDH3A1
has only substance units: false
is: P30838
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110009#_5be23bda_b6df_4606_ad6b_43a509b0ae18
type: Species
has only substance units: false
is encoded by: hsa:122622
is: B3KTV4
initial amount: NaN
constant: false
name: ADSSL1
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR NACHEX15ly
modifier: MODEL1310110009#
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
reactant: MODEL1310110009#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110009#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
product: MODEL1310110009#

metaR r0081
type: Reaction
kinetic law: MODEL1310110009#
is: SBO:0000176
product: MODEL1310110009#
reversible: true
reactant: MODEL1310110009#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110009#
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.12
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2

metaM hs deg19 l
is: HMDB01352
name: heparan sulfate, degradation product 19
is: SBO:0000247
has only substance units: false
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:17180
type: Species
initial concentration: 1.0

metaR r2139
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
product: MODEL1310110009#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110009#

metaR SIAASE2ly
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
reversible: false
type: Reaction
is described by: ECO:0000000
name: sialidase, lysosomal
fast: false
product: MODEL1310110009#
reactant: MODEL1310110009#
kinetic law: MODEL1310110009#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR AMPtp
kinetic law: MODEL1310110009#
product: MODEL1310110009#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: AMP transporter, peroxisome
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
reactant: MODEL1310110009#
reversible: true

metaR MTHFD2m
is described by: ECO:0000254
fast: false
modifier: MODEL1310110009#
kinetic law: MODEL1310110009#
reactant: MODEL1310110009#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true
product: MODEL1310110009#
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD

metaR CORE3GTg
fast: false
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110009#
reversible: false
kinetic law: MODEL1310110009#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110009#
modifier: MODEL1310110009#
type: Reaction
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110009#_bee4e600_baa8_4dde_9a7a_b4c15d99ecba
type: Species
is: Q02338
name: BDH1
is encoded by: hsa:622
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

metaM lnlncg l
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:32391
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
has only substance units: false
is: HMDB03073
name: gamma-linolenate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110009#_b52a0442_34d4_4105_ba9e_9eb751c10305
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: ACAD9
is: Q9H845
constant: false
has only substance units: false
is encoded by: hsa:28976

metaR PUNP7
fast: false
kinetic law: MODEL1310110009#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
modifier: MODEL1310110009#
product: MODEL1310110009#
name: purine-nucleoside phosphorylase (Xanthosine)
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
reactant: MODEL1310110009#

metaM m4mpdol U r
type: Species
initial amount: NaN
is: CHEBI:37633
has only substance units: false
is: SBO:0000247
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
initial concentration: 1.0
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
boundary condition: false
constant: false