metaM CE2432 m
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57795
constant: false
type: Species
boundary condition: false
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
initial amount: NaN
has only substance units: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432

metaM arachdcoa c
is: CHEBI:57368
has only substance units: false
is: SBO:0000247
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
constant: false
type: Species
name: arachidonoyl-CoA(4-)
is: HMDB06523
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM tetdec2crn c
constant: false
is: HMDB02014
boundary condition: false
notes: FORMULA: C21H37NO4 CHARGE: 0
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
name: tetradecadienoyl carnitine
initial concentration: 1.0

metaM gdp e
initial concentration: 1.0
constant: false
initial amount: NaN
name: GDP(3-)
is: CHEBI:58189
is: HMDB01201
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035

metaR HESTRATRIOLtr
reactant: MODEL1310110008#
type: Reaction
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110008#
product: MODEL1310110008#
name: hydroxylated estrogen derivative transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be transported out of the cell NJ

metaR A4GALTg
modifier: MODEL1310110008#
reversible: false
kinetic law: MODEL1310110008#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.228
name: Lactosylceramide 4-alpha-galactosyltransferase
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110008#
product: MODEL1310110008#

metaR NRPPHRtu
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reversible: true
is: SBO:0000185
type: Reaction
name: Norepinephrine uniport
modifier: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
is described by: ECO:0000269

metaR S6TASE14ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
reactant: MODEL1310110008#
modifier: MODEL1310110008#

metaM HC00319 m
is: SBO:0000247
constant: false
name: Malonate
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:30794
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
boundary condition: false
type: Species

metaM pail5p hs n
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: CHEBI:57795

metaM dcsptn1coa x
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
constant: false
is: http://identifiers.org/pubchem.compound/47205483
is: HMDB06513
is: C16173
initial amount: NaN
has only substance units: false

metaR r1728
modifier: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport

metaM c8crn c
constant: false
initial amount: NaN
name: octanoyl carnitine
is: HMDB00791
initial concentration: 1.0
has only substance units: false
type: Species
is: C02838
is: SBO:0000247
boundary condition: false
notes: FORMULA: C15H29NO4 CHARGE: 0

metaM spc hs e
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/5311445
name: sphingosylphosphorylcholine
constant: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110008#_a3a0ee46_a16e_40b9_8425_49d324bae827
is: SBO:0000252
name: PFKL
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:5211
is: Q7L2M7

http://identifiers.org/biomodels.db/MODEL1310110008#_44fe1288_02ec_4a38_abd4_35811f9d4d6f
has only substance units: false
constant: false
name: GALT
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2592
is: E7ET32
initial amount: NaN

metaR C8CRNe
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octanoyl carnitine into the extra cellular space
type: Reaction

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

metaM met L e
initial amount: NaN
is: SBO:0000247
is: CHEBI:16643
has only substance units: false
is: HMDB00696
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
boundary condition: false
constant: false
initial concentration: 1.0
name: L-methionine
type: Species

metaM m2mn l
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
type: Species
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB06537

http://identifiers.org/biomodels.db/MODEL1310110008#_717cee61_a37c_41ca_8641_ac3050fa50f5
initial concentration: NaN
constant: false
is: Q02742
is encoded by: hsa:2650
type: Species
initial amount: NaN
has only substance units: false
name: GCNT1
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_c0e2d523_25d4_4f1e_91b2_fc4c8e809d2c
name: AMACR
is: Q3KT79
type: Species
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:23600
has only substance units: false

metaR r0821
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110008#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000000
fast: false
reversible: true

metaM gdp c
is: CHEBI:58189
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB01201
name: GDP
type: Species
is: C00035
is: SBO:0000247
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_ce0a2a26_5b4a_456e_96e8_40ce1f2eaeba
initial amount: NaN
is: SBO:0000252
name: AKR1D1
constant: false
type: Species
is encoded by: hsa:6718
has only substance units: false
initial concentration: NaN
is: P51857
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_c0d7f1c2_304d_4760_bdc4_8b25e2aac66a
initial amount: NaN
boundary condition: true
is encoded by: hsa:79369
type: Species
has only substance units: false
constant: false
is: Q9C0J1
is: SBO:0000252
name: B3GNT4
initial concentration: NaN

metaM arg L m
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: L-argininium(1+)
constant: false
initial concentration: 1.0
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: CHEBI:32682
is: HMDB00517
type: Species
boundary condition: false

metaM CE4723 e
has only substance units: false
is: C01936
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5041
notes: FORMULA: C29H40N5O9 CHARGE: -1 INCHI: InChI=1/C29H41N5O9/c1-16(2)24(26(39)31-20(11-12-23(36)37)28(41)34-14-4-6-22(34)29(42)43)32-25(38)21-5-3-13-33(21)27(40)19(30)15-17-7-9-18(35)10-8-17/h7-10,16,19-22,24,35H,3-6,11-15,30H2,1-2H3,(H,31,39)(H,32,38)(H,36,37)(H,42,43)/p-1/t19-,20-,21-,22-,24+/m1/s1 EHMN_ABBREVIATION: CE4723
initial amount: NaN
name: neocasomorphin (1-5)
type: Species
boundary condition: false
constant: false
is: SBO:0000247

metaM ahcys e
has only substance units: false
is: SBO:0000247
notes: FORMULA: C14H20N6O5S CHARGE: 0
type: Species
is: CHEBI:16680
constant: false
name: S-Adenosyl-L-homocysteine
is: HMDB00939
is: C00021
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaM 3octdeccrn e
has only substance units: false
is: HMDB13336
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C25H49NO5 CHARGE: 0
constant: false
name: 3-hydroxyoctadecanoyl carnitine

metaR AG13T17g
product: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110008#

metaM hdd2coa c
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: trans-Hexadec-2-enoyl-CoA
type: Species
is: C05272
is: CHEBI:61526
is: SBO:0000247
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
boundary condition: false
is: HMDB03945

metaM g2m8mpdol U r
constant: false
has only substance units: false
is: CHEBI:59093
notes: FORMULA: C1845H3040N20O720P20 CHARGE: -20
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaM c8crn e
notes: FORMULA: C15H29NO4 CHARGE: 0
constant: false
initial amount: NaN
is: HMDB00791
initial concentration: 1.0
name: octanoyl carnitine
type: Species
is: C02838
is: SBO:0000247
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_65d1b4ec_1bea_43f5_88da_5a77d0f4e987
is: SBO:0000297
constant: false
type: Species
initial amount: NaN
has part: P56134
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:522
is encoded by: hsa:9551
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2

metaR FAOXC141C121m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C12:1)m
type: Reaction

metaR S6T11g
kinetic law: MODEL1310110008#
fast: false
type: Reaction
modifier: MODEL1310110008#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110008#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110008#

metaR r0822
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110008#
type: Reaction
fast: false
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110008#
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2

metaM dolmanp L r
is: CHEBI:15809
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
name: Dolichyl phosphate D-mannose, human liver homolog
initial amount: NaN
has only substance units: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
constant: false

metaM spc hs c
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: sphingosylphosphorylcholine
type: Species
is: SBO:0000247
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
is: http://identifiers.org/pubchem.compound/5311445
constant: false

metaR 2HCO3 NAt
reactant: MODEL1310110008#
is described by: ECO:0000269
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
fast: false
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM

metaR FAOXC17C15m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C17-->C15)m
type: Reaction

metaM 3octdeccrn c
constant: false
initial amount: NaN
name: 3-hydroxyoctadecanoyl carnitine
is: HMDB13336
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C25H49NO5 CHARGE: 0
boundary condition: false
has only substance units: false

metaR FAOXC123m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

metaR EX 3hexdcrn
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_241a0e33_99eb_4a88_9d91_dae97132a0d9
name: SLC24A1
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: B4DUG1
type: Species
is encoded by: hsa:9187
is: SBO:0000252

metaM dcsptn1 e
is: SBO:0000247
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoic acid
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
type: Species
is: http://identifiers.org/pubchem.compound/5282848
is: HMDB13123

metaM met L c
boundary condition: false
is: HMDB00696
initial amount: NaN
is: CHEBI:16643
constant: false
type: Species
has only substance units: false
name: L-methionine
initial concentration: 1.0
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_510f2014_4500_47e8_990c_1f08b96c9ffb
is encoded by: hsa:2878
has only substance units: false
initial amount: NaN
type: Species
is: P22352
name: GPX3
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_b95c0e07_be98_4356_b64b_767f63305692
has part: P15531
is: SBO:0000297
has part: P22392
is encoded by: hsa:4831
initial concentration: NaN
is encoded by: hsa:4830
has only substance units: false
name: NME1:NME2
boundary condition: true
type: Species
initial amount: NaN
constant: false

metaR EX prgstrn LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Progesterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_f1d44b64_60ed_43b9_98fd_5b415346c9ea
is encoded by: hsa:374907
name: B3GNT8
boundary condition: true
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM o2 n
has only substance units: false
boundary condition: false
is: HMDB01377
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
constant: false
type: Species
name: dioxygen
is: CHEBI:15379

http://identifiers.org/biomodels.db/MODEL1310110008#_176b9fdc_6ce4_4794_bbda_14eb5b86bbb8
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10873
boundary condition: true
is: Q6TCH8
name: ME3
constant: false
is: SBO:0000252
initial amount: NaN
type: Species

metaR r0074
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
fast: false
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/6.2.1.1
is described by: ECO:0000000
reactant: MODEL1310110008#
reversible: true
modifier: MODEL1310110008#
is: SBO:0000176
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
type: Reaction
product: MODEL1310110008#

metaR FAOXC1811602m
name: Beta oxidation fatty acid
type: Reaction
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#

metaM bilirub e
is: CHEBI:57977
initial amount: NaN
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
name: bilirubin(2-)
is: HMDB00054
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_0a3bb5ac_35ff_48ae_8fa1_89b4facb18a4
is: B4DYG5
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:5297
name: PI4KA
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM glyphe e
is: http://identifiers.org/pubchem.compound/97415
initial concentration: 1.0
name: Glycylphenylalanine
constant: false
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C11H14N2O3 CHARGE: 0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_f432edc5_765c_4c1d_aeb1_2b1c84a96d58
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: PDE9A
constant: false
is encoded by: hsa:5152
has only substance units: false
initial concentration: NaN
type: Species

metaR EX aprgstrn LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 20alpha-Hydroxyprogesterone exchange
type: Reaction

metaR EX lgnc LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lignoceric acid exchange
type: Reaction

metaR S4TASE4ly
type: Reaction
modifier: MODEL1310110008#
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.6.12
fast: false
product: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110008#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
reversible: true

metaM cs a deg4 l
has only substance units: false
boundary condition: false
is: CHEBI:57455
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C31H49NO29S CHARGE: -2
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
is: HMDB01354
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_a3b1c329_8ac8_45f4_bfde_43007b4a6014
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:26266
name: SLC13A4
initial concentration: NaN
is: Q9UKG4
has only substance units: false

metaM tetd7ecoa m
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
constant: false
boundary condition: false
is: SBO:0000247
name: 7-tetradecenoylcoa
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB13109
initial amount: NaN

metaM o2 m
is: CHEBI:15379
boundary condition: false
is: SBO:0000247
is: C00007
is: HMDB01377
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
name: O2
has only substance units: false

metaM octe5coa x
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
name: 5-octenoylcoa

metaR HPYRRy
is: SBO:0000176
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.79
fast: false
is described by: ECO:0000269
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:2689175,PMID:9038835 NOTES:JLR
name: Hydroxypyruvate reductase (NADPH)
reversible: false
product: MODEL1310110008#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_461248d4_3a37_4970_9d82_c1847de3a6ec
boundary condition: true
type: Species
has part: A8K092
is encoded by: hsa:513
has part: P36542
is encoded by: hsa:514
is encoded by: hsa:506
is: SBO:0000297
initial concentration: NaN
has part: P30049
has part: P56381
has part: P06576
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
has only substance units: false
is encoded by: hsa:509
is encoded by: hsa:498
constant: false
initial amount: NaN

metaR RE3269C
name: RE3269
product: MODEL1310110008#
modifier: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.48
fast: false
type: Reaction

metaR C14OHc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecanoylcarnitine
type: Reaction

metaR r2514
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
type: Reaction
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reversible: true

metaR ECOAH12m
type: Reaction
modifier: MODEL1310110008#
product: MODEL1310110008#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
kinetic law: MODEL1310110008#
is described by: ECO:0000304
fast: false

metaM dcsptn1 c
is: HMDB13123
name: docosa-4,7,10,13,16-pentaenoic acid
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/5282848
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
initial amount: NaN
is: SBO:0000247

metaM ksi deg36 l
constant: false
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I, degradation product 36
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
initial amount: NaN
is: CHEBI:12936
type: Species
has only substance units: false
boundary condition: false
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110008#_70c55ee5_a933_40b1_8e97_d14472d07afe
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI373818
constant: false
is: SBO:0000252
name: _AI373818_1_m

metaR sink octdececoa LPAREN c RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: OCTDECECOASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_5d246a37_f672_4016_b722_9dbc0a213359
is encoded by: hsa:4697
is: O00483
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
name: NDUFA4
constant: false
boundary condition: true
has only substance units: false

metaM cs a deg2 l
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C37H55NO38S2 CHARGE: -4
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2
is: HMDB00127
is: CHEBI:15748
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false

metaM gdp g
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:58189
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
type: Species
name: GDP(3-)
initial amount: NaN
is: HMDB01201

metaR DM ethamp r
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaM HC02207 c
is: CHEBI:27555
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
name: prostaglandin-c2

metaM tetdec2crn e
name: tetradecadienoyl carnitine
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C21H37NO4 CHARGE: 0
initial amount: NaN
is: HMDB05066
is: SBO:0000247
constant: false

metaM CE2420 m
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
is: CHEBI:28387
is: HMDB11123
initial amount: NaN
constant: false

metaR RE3242R
is described by: ECO:0000000
product: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
reversible: true
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is: SBO:0000176
name: RE3242
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_a63bf9b7_1ba7_4700_aeb5_91a482160881
has only substance units: false
name: BDH1
boundary condition: true
constant: false
initial concentration: NaN
is: Q02338
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:622

metaM glyphe c
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/97415
name: Glycylphenylalanine
has only substance units: false
notes: FORMULA: C11H14N2O3 CHARGE: 0
type: Species
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR CYANtm
product: MODEL1310110008#
type: Reaction
fast: false
name: Cyanide transport via diffusion (mitochondrial)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
is: SBO:0000185
kinetic law: MODEL1310110008#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_32e4c725_a2e2_4b4c_84db_846125b3da67
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6576
is: D9HTE9
name: SLC25A1

metaR CERT2gt
product: MODEL1310110008#
is described by: ECO:0000000
name: ceramide transport protein
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
reversible: true
modifier: MODEL1310110008#
is: SBO:0000185
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_384213ca_49b5_41c1_aef2_9969d071ff97
is encoded by: hsa:8802
is: P53597
constant: false
name: SUCLG1
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true

metaM gly x
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: SBO:0000247
is: HMDB00123
name: glycine
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:15428
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_33828340_5b99_4837_acf7_203622aafafd
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:4598
is: SBO:0000252
has only substance units: false
is: B2RDU6
constant: false
name: MVK
initial amount: NaN

metaM leuktrF4 e
initial amount: NaN
boundary condition: false
is: CHEBI:27491
initial concentration: 1.0
type: Species
name: leukotriene F4
is: HMDB06465
has only substance units: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
constant: false
is: SBO:0000247

metaR r0340
is described by: ECO:0000000
reversible: false
is: SBO:0000176
fast: false
modifier: MODEL1310110008#
type: Reaction
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.3.1.38

metaR EX CE2915 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-casomorphin exchange
type: Reaction

metaM l2fn2m2masn g
notes: FORMULA: C68H113N4O49X CHARGE: 0
is: CHEBI:28067
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine

http://identifiers.org/biomodels.db/MODEL1310110008#_f5673918_a8d4_432c_8b62_a8e2c5746d19
is encoded by: hsa:54995
is: SBO:0000252
is: Q9NWU1
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
name: OXSM

metaR RE2799C
type: Reaction
product: MODEL1310110008#
is: SBO:0000176
reactant: MODEL1310110008#
name: RE2799
kinetic law: MODEL1310110008#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
is described by: ECO:0000000

metaR SCP22x
name: Sterol carrier protein 2
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
fast: false
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000185
modifier: MODEL1310110008#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.176
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110008#_03ddfa1e_ad2e_43bd_8487_c0c5db465740
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000297
boundary condition: true
initial concentration: NaN
is encoded by: hsa:517
type: Species
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
has part: Q06055

metaR ACNAMlt
reactant: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000269
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
type: Reaction
is: SBO:0000185
fast: false
name: N-acetylneuraminate transport into lysososme
reversible: true
kinetic law: MODEL1310110008#

metaR SERGLNexR
kinetic law: MODEL1310110008#
reversible: true
is described by: ECO:0000304
name: L-Serine/Glutamine reversible exchange
modifier: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110008#

metaR NTP3e
reactant: MODEL1310110008#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: false
name: nucleoside-triphosphatase (GTP)
is version of: http://identifiers.org/ec-code/3.6.1.6
modifier: MODEL1310110008#
fast: false

metaR RE2069C
reactant: MODEL1310110008#
is: SBO:0000176
name: RE2069
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
type: Reaction
product: MODEL1310110008#
reversible: true
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_ff9b7cc3_206a_4ae8_be31_ea50ce2ffbd2
name: RPIA
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is: P49247
initial concentration: NaN
boundary condition: true
is encoded by: hsa:22934

metaM ksi pre28 g
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
constant: false
is: CHEBI:58053
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 28
has only substance units: false
is: HMDB00175
initial concentration: 1.0
boundary condition: false
is: C00130
initial amount: NaN
type: Species

metaR FAOXC226205m
fast: false
reversible: false
reactant: MODEL1310110008#
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110008#_261e8c4d_6c5d_4e4b_b29f_c904ea8c29cf
is encoded by: hsa:8875
constant: false
is: O95498
name: VNN2
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_0eb5789b_099c_4917_9962_7be355d272eb
name: _AA021081_1_r
type: Species
initial amount: NaN
is encoded by: hsa:AA021081
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR RE1807C
name: RE1807
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is: SBO:0000176
fast: false
reactant: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000

metaR r0932
type: Reaction
fast: false
kinetic law: MODEL1310110008#
name: Transport reaction
reactant: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM orn e
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: C01602
notes: FORMULA: C5H13N2O2 CHARGE: 1
name: Ornithine
type: Species
is: CHEBI:0
is: HMDB00214

http://identifiers.org/biomodels.db/MODEL1310110008#_cd411c96_d6a4_4eef_abf9_5a83d351d2c9
is encoded by: hsa:2805
boundary condition: true
is: P17174
initial amount: NaN
name: GOT1
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
has only substance units: false

metaR r1720
reversible: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110008#
is: SBO:0000185
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110008#
fast: false
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110008#

metaR UDPtl
type: Reaction
fast: false
name: udp intracellular transport
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaM gdp m
name: GDP
has only substance units: false
type: Species
is: C00035
initial concentration: 1.0
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
boundary condition: false
initial amount: NaN
is: CHEBI:58189
is: HMDB01201
constant: false
is: SBO:0000247

metaM gdp n
initial amount: NaN
name: GDP(3-)
is: CHEBI:58189
constant: false
is: SBO:0000247
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_7a01c656_9d82_4c7f_a42d_3d6377082778
has only substance units: false
initial concentration: NaN
is: P24752
is encoded by: hsa:38
name: ACAT1
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false

metaR MI13PP
reversible: false
reactant: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#
name: inositol-1,3-bisphosphate 3-phosphatase
kinetic law: MODEL1310110008#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_473d0063_8031_4b24_a977_408c0029b88b
name: SLC13A1
is encoded by: hsa:6561
initial concentration: NaN
is: Q9BZW2
is: SBO:0000252
constant: false
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN

metaM bilirub r
constant: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
name: bilirubin(2-)
is: SBO:0000247
initial amount: NaN
is: HMDB00054
is: CHEBI:57977

metaR r1721
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000185
modifier: MODEL1310110008#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110008#
name: Y+LAT2 Utilized transport

metaR GASNASE2ly
type: Reaction
reactant: MODEL1310110008#
name: glycosylasparaginase, lysosomal
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.26
is described by: ECO:0000000
product: MODEL1310110008#
is: SBO:0000176
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110008#

metaR r1020
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110008#
type: Reaction
name: Postulated transport reaction
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110008#_9d93c552_a032_49be_a32c_bdbb8e11eda2
is: Q99884
type: Species
name: SLC6A7
is encoded by: hsa:6534
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN

metaM o2 c
name: O2
is: CHEBI:15379
is: HMDB01377
constant: false
boundary condition: false
type: Species
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR CRNrtx
reactant: MODEL1310110008#
type: Reaction
reversible: true
kinetic law: MODEL1310110008#
name: reversible transport of L-Carnitine in peroxisome
is: SBO:0000185
is described by: ECO:0000134
product: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.

metaR LAPCOAl
product: MODEL1310110008#
is: SBO:0000176
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (53.1) SUBSYSTEM: CoA catabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:11923312,PMID:11994049 NOTES:IT. human enzymes overexpressed on E.coli, Pig Liver
fast: false
modifier: MODEL1310110008#
is described by: ECO:0000304
name: lysosomal acid phosphorylase (CoA)
is version of: http://identifiers.org/ec-code/3.1.3.2
reversible: false
type: Reaction

metaR M4MPDOL Uter
is: SBO:0000185
product: MODEL1310110008#
reversible: false
name: m4mpdol flippase
fast: false
reactant: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:

metaR LNLCCPT1
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110008#
name: carnitine O-palmitoyltransferase
is described by: ECO:0000269
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000176
fast: false
reversible: false
product: MODEL1310110008#

metaM HC00319 c
boundary condition: false
constant: false
has only substance units: false
name: Malonate
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
is: CHEBI:30794
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species

metaR EX pydx5p LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of pyridoxal 5-phosphate(2-)
type: Reaction

metaM elaidcrn m
name: Elaidic carnitine
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
type: Species
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
initial amount: NaN
is: HMDB06464

metaR r0934
fast: false
reversible: false
reactant: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110008#
product: MODEL1310110008#
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction

metaM nrvnccoa x
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
boundary condition: false
name: nervonyl coenzyme A
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: C16532
type: Species

metaR r0345
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110008#
modifier: MODEL1310110008#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.3.99.13
reactant: MODEL1310110008#
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110008#_4dde7676_4081_4790_b17e_ac3cbf0acee8
initial amount: NaN
boundary condition: true
is encoded by: hsa:HG2846-HT2983
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
name: _HG2846_HT2983_1_m
type: Species

metaM lald D c
has only substance units: false
name: (R)-lactaldehyde
type: Species
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
initial concentration: 1.0
is: CHEBI:17167
is: HMDB06458
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247

metaM mi13p c
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB06234
name: 1D-myo-Inositol 1,3-bisphosphate
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
is: CHEBI:18225
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

metaR S6T9g
fast: false
modifier: MODEL1310110008#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110008#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
product: MODEL1310110008#
is: SBO:0000176
reactant: MODEL1310110008#

metaM gdpfuc c
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB01095
is: SBO:0000247
is: CHEBI:57984
boundary condition: false
type: Species
name: GDP-L-fucose(2-)
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
constant: false

metaM arg L e
is: SBO:0000247
type: Species
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: CHEBI:32682
initial amount: NaN
is: HMDB00517
boundary condition: false
name: L-argininium(1+)
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_94a7d55c_ff04_4aa3_bc9a_9d199edd4435
name: FUCA1
constant: false
is: P04066
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2517

http://identifiers.org/biomodels.db/MODEL1310110008#_c2701597_2944_439f_82d8_126a45d0018c
is: Q9NUD9
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: PIGV
is encoded by: hsa:55650
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_dcf89127_1799_4e53_8eb2_579735019ac4
is: SBO:0000297
has part: Q9NY65
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
name: EHHADH:ACAA1:ACOX1
is encoded by: hsa:1962
type: Species

metaM HC01405 m
is: CHEBI:28632
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
name: (S)-Hydroxyoctanoyl-CoA
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
type: Species

metaM c6dc c
initial concentration: 1.0
name: adipoyl carnitine
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C13H22NO6 CHARGE: -1
is: HMDB00705
type: Species
boundary condition: false
constant: false

metaM o2 e
is: HMDB01377
boundary condition: false
initial concentration: 1.0
is: C00007
is: SBO:0000247
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
name: O2

http://identifiers.org/biomodels.db/MODEL1310110008#_a9c30702_f8d2_4459_b7de_4fd9e9ba6cb8
is: B7Z7I0
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is encoded by: hsa:8277
initial concentration: NaN
name: TKTL1
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_cd64bf29_d1de_4414_84c0_d24d3d094321
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:1606
has only substance units: false
name: DGKA
is: SBO:0000252
is: P23743
type: Species
initial concentration: NaN

metaM HC00361 c
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
name: sedoheptulose 1,7-bisphosphate(4-)
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
is: SBO:0000247
is: CHEBI:58335
boundary condition: false

metaR NACHEX3ly
is: SBO:0000176
kinetic law: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
modifier: MODEL1310110008#
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110008#

metaR ARACHCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
product: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: fatty acid intracellular transport
kinetic law: MODEL1310110008#
reversible: true
reactant: MODEL1310110008#

metaM ahcys c
is: C00021
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: S-Adenosyl-L-homocysteine
is: HMDB00939
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: SBO:0000247
is: CHEBI:16680
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_ca1f08f2_de72_4c3b_8dd0_a5176f1aee28
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: SDHD
boundary condition: true
constant: false
type: Species
is encoded by: hsa:6392
is: O14521

metaM arg L c
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
boundary condition: false
is: HMDB00517
name: L-argininium(1+)
has only substance units: false
is: CHEBI:32682
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247

metaR r0603
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.12
reversible: true
reactant: MODEL1310110008#
is: SBO:0000176
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
type: Reaction
kinetic law: MODEL1310110008#
fast: false
product: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:

metaR GLCAASE4ly
name: beta-glucuronidase, lysosomal
type: Reaction
product: MODEL1310110008#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.31
is: SBO:0000176
modifier: MODEL1310110008#
reversible: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_4c5f3c77_e479_4bdd_aa78_232aaba78abd
boundary condition: true
constant: false
is: Q14410
has only substance units: false
initial amount: NaN
is encoded by: hsa:2712
name: GK2
type: Species
initial concentration: NaN
is: SBO:0000252

metaM tethex3 e
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB02007
initial concentration: 1.0
has only substance units: false
name: tetracosahexaenoic acid, n-3
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
constant: false
initial amount: NaN

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaM CE0693 m
boundary condition: false
initial amount: NaN
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
has only substance units: false
constant: false
is: SBO:0000247
name: 3-oxolaur-6-cis-enoyl-CoA
initial concentration: 1.0
type: Species
is: CHEBI:28387
is: HMDB11123

metaR CYANt
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
product: MODEL1310110008#
type: Reaction
is: SBO:0000185
name: Cyanide transport via diffusion (extracellular to cytosol)
reactant: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#

metaR LNLCCPT2
reactant: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110008#
is: SBO:0000176
reversible: false
product: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
type: Reaction

metaM c10dc x
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C17H30NO6 CHARGE: -1
is: HMDB00651
name: sebacoyl carnitine

metaR G14T5g
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110008#
is described by: ECO:0000000
fast: false
reversible: false
product: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD

metaM ksii core4 pre4 g
initial amount: NaN
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 4
type: Species
is: C00130
is: HMDB00175
is: CHEBI:58053
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C61H99N5O43X CHARGE: -1

metaM acgpail hs c
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
has only substance units: false
boundary condition: false
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
type: Species
is: CHEBI:57265
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN

metaR GLXtp
reversible: true
name: glyoxylate transport, peroxisomal
reactant: MODEL1310110008#
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
type: Reaction
product: MODEL1310110008#

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaR r2408
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
modifier: MODEL1310110008#
reactant: MODEL1310110008#
reversible: false
fast: false
type: Reaction
product: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110008#
is: SBO:0000185

metaR ARACHDCOAtx
kinetic law: MODEL1310110008#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
reversible: true
product: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
is described by: ECO:0000000

metaM CE5868 e
is: HMDB02710
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C9H12N2O7 CHARGE: -2 INCHI: InChI=1/C9H14N2O7/c1-4(13)10-6(3-12)8(16)11-5(9(17)18)2-7(14)15/h5-6,12H,2-3H2,1H3,(H,10,13)(H,11,16)(H,14,15)(H,17,18)/p-2/t5-,6+/m1/s1 EHMN_ABBREVIATION: CE5868
is: CHEBI:27485
boundary condition: false
name: N-acetyl-seryl-aspartate
type: Species
has only substance units: false
initial amount: NaN

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_7bfa3de8_a5f5_4737_ade6_5378cf887f6a
constant: false
name: COX3
type: Species
is: P00414
is encoded by: hsa:4514
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_a96ff31e_be0b_406f_b46a_bc7404c84791
is: Q16842
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6483
constant: false
initial amount: NaN
name: ST3GAL2
boundary condition: true

metaM tethex3 c
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB02007
name: tetracosahexaenoic acid, n-3
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-

metaR r1722
product: MODEL1310110008#
is: SBO:0000185
modifier: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110008#
name: Y+LAT2 Utilized transport
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110008#
reversible: false

metaM orn c
type: Species
is: CHEBI:0
initial concentration: 1.0
constant: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: SBO:0000247
initial amount: NaN
is: C01602
is: HMDB00214
name: Ornithine
boundary condition: false
has only substance units: false

metaM gdpfuc g
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
constant: false
boundary condition: false
is: CHEBI:57984
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01095
type: Species
name: GDP-L-fucose(2-)
has only substance units: false

metaR GLXtm
is: SBO:0000185
reactant: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
fast: false
reversible: true
name: glyoxylate transport, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110008#_0117d0bc_d325_4953_ab96_3697041a33bc
boundary condition: true
is: Q3I5F7
name: ACOT6
is encoded by: hsa:641372
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_5487a778_f0cd_4037_82a7_dfaab8b94c57
boundary condition: true
is encoded by: hsa:5283
constant: false
name: PIGH
initial amount: NaN
is: SBO:0000252
is: Q14442
type: Species
has only substance units: false
initial concentration: NaN

metaM nad x
is: CHEBI:57540
is: http://identifiers.org/pubchem.compound/3305
is: SBO:0000247
has only substance units: false
type: Species
is: C00003
is: HMDB00902
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
name: Nicotinamide adenine dinucleotide

metaM 5adtststerone r
constant: false
initial amount: NaN
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
name: 17beta-hydroxy-5alpha-androstan-3-one
initial concentration: 1.0
has only substance units: false
is: CHEBI:16330
boundary condition: false
is: HMDB02961
is: SBO:0000247
type: Species

metaR r1723
modifier: MODEL1310110008#
product: MODEL1310110008#
reversible: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185

metaR r0931
type: Reaction
is: SBO:0000185
reactant: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false

metaR COUCOAFm
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: 6.2.1.12 Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine. (EC 6.2.1.12) .
product: MODEL1310110008#
is: SBO:0000176
kinetic law: MODEL1310110008#
type: Reaction
fast: false
is described by: ECO:0000000
name: p-coumaroyl-CoA formation
reversible: false

metaR GLYCTO1p
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.3.15
product: MODEL1310110008#
fast: false
is: SBO:0000176
modifier: MODEL1310110008#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
name: Glycolate oxidase, peroxisome
reactant: MODEL1310110008#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110008#_622f91df_df9b_48ec_aad3_613b180f1efe
type: Species
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: P43304
is: SBO:0000252
initial amount: NaN
name: GPD2
is encoded by: hsa:2820

metaR RE1516M
product: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.13
reversible: true
is: SBO:0000176
reactant: MODEL1310110008#
name: RE1516
fast: false
modifier: MODEL1310110008#

metaR r1593
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110008#
fast: false
product: MODEL1310110008#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110008#
is described by: ECO:0000000
type: Reaction

metaM hexdtrcoa m
type: Species
is: HMDB02288
is: SBO:0000247
constant: false
name: 7,10,13-hexadecatrienoylcoa
boundary condition: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaM abt e
is: CHEBI:18403
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
name: L-arabinitol
is: SBO:0000247
is: HMDB01851

metaR BHBt
reversible: true
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
is described by: ECO:0000000
name: (R)-3-Hydroxybutanoate transport via H+ symport
is: SBO:0000185
type: Reaction
product: MODEL1310110008#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_1a21fc6d_0516_44dd_95a3_5bcbf3ab31a8
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
name: CMPK1
is encoded by: hsa:51727
is: B2R6S5

metaM nadph x
initial amount: NaN
is: CHEBI:57783
initial concentration: 1.0
is: C00005
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
has only substance units: false
is: HMDB00221
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005

metaM c10dc c
initial concentration: 1.0
constant: false
notes: FORMULA: C17H30NO6 CHARGE: -1
boundary condition: false
name: sebacoyl carnitine
is: HMDB00651
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM dolmanp L c
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
name: Dolichyl phosphate D-mannose, human liver homolog
is: SBO:0000247
is: CHEBI:15809
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial concentration: 1.0
type: Species

metaM glyleu c
boundary condition: false
initial concentration: 1.0
is: C02155
is: http://identifiers.org/pubchem.compound/102468
type: Species
name: Glycylleucine
is: HMDB00759
is: SBO:0000247
notes: FORMULA: C8H16N2O3 CHARGE: 0
initial amount: NaN
constant: false
has only substance units: false

metaR FACOAL226
kinetic law: MODEL1310110008#
is: SBO:0000176
fast: false
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110008#
reversible: true
name: fatty-acid--CoA ligase
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110008#_2a97e365_511e_422a_9174_fc881960045d
initial amount: NaN
constant: false
is encoded by: hsa:8501
type: Species
has only substance units: false
name: SLC43A1
is: SBO:0000252
initial concentration: NaN
is: O75387
boundary condition: true

metaR GALASE10ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110008#
name: beta-galactosidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: false
is: SBO:0000176

metaR G13MT U
reactant: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.132
name: Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)
fast: false
modifier: MODEL1310110008#
reversible: false
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_a3884f9a_6e79_4758_bf96_87fb28792021
is encoded by: hsa:1798
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: DPAGT1
constant: false
type: Species
initial concentration: NaN
has only substance units: false

metaR r1592
fast: false
kinetic law: MODEL1310110008#
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110008#
is: SBO:0000185
product: MODEL1310110008#
reversible: true

metaM ksi deg4 l
name: keratan sulfate I, degradation product 4
initial concentration: 1.0
is: CHEBI:57737
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
is: HMDB00868
initial amount: NaN
is: SBO:0000247
type: Species

metaM 4aphdob c
boundary condition: false
is: CHEBI:58147
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00978
type: Species
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
initial concentration: 1.0

metaR PHCHGSm
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110008#
reversible: true
reactant: MODEL1310110008#
product: MODEL1310110008#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_58c481e8_063b_453e_a0d2_396a547daded
initial amount: NaN
is: P15954
is: SBO:0000252
type: Species
constant: false
name: COX7C
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1350

metaM thcholstoic c
is: SBO:0000247
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: HMDB03873
initial concentration: 1.0
constant: false
is: CHEBI:18402

http://identifiers.org/biomodels.db/MODEL1310110008#_dc832c86_5760_4573_bcb3_484a51f2e5ef
has only substance units: false
is encoded by: hsa:AL038231
boundary condition: true
type: Species
name: _AL038231_1_c
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_cea8ade7_4cc4_4876_b30f_e0889ca0177a
is: SBO:0000252
name: SLC27A1
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:376497
is: Q6PCB7
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_5cfcf116_166d_4f47_a479_11dda769ac15
is: Q9ULC5
type: Species
is encoded by: hsa:51703
constant: false
boundary condition: true
name: ACSL5
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR ACCOAtn
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reversible: true
product: MODEL1310110008#
name: acetyl-CoA transport, nuclear
is: SBO:0000185
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#

metaM retinal c
is: SBO:0000247
name: retinal
is: CHEBI:15035
boundary condition: false
constant: false
has only substance units: false
is: HMDB01358
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
initial amount: NaN
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_7500916e_b612_4750_8566_c7475b7e799f
is encoded by: hsa:1644
initial concentration: NaN
has only substance units: false
is: Q53Y41
initial amount: NaN
name: DDC
type: Species
constant: false
boundary condition: true
is: SBO:0000252

metaR r1595
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110008#
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false

metaR r1018
is: SBO:0000185
kinetic law: MODEL1310110008#
name: Transport reaction
reactant: MODEL1310110008#
fast: false
product: MODEL1310110008#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110008#_5db04fdd_4b28_4924_8cee_14102be239d5
name: ENPP3
is: SBO:0000252
is encoded by: hsa:5169
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: Q308M7
constant: false

metaR BACCL
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
is: SBO:0000176
name: biotin-[acetyl-CoA-carboxylase] ligase
is described by: ECO:0000269
type: Reaction
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: false
reactant: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.10
modifier: MODEL1310110008#

metaR C4CRNCPT2
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of butyryl carnitine in the mitochondrial matrix for final hydrolysis
type: Reaction

metaM glyleu e
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/102468
is: C02155
is: HMDB00759
type: Species
is: SBO:0000247
initial amount: NaN
name: Glycylleucine
notes: FORMULA: C8H16N2O3 CHARGE: 0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_870c48cb_0ce4_43d9_abda_5806a3d65d79
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:1635
initial concentration: NaN
boundary condition: true
is: P32321
is: SBO:0000252
has only substance units: false
name: DCTD

http://identifiers.org/biomodels.db/MODEL1310110008#_9093a282_1ccc_41f8_8db8_0f4e1a84b712
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:51022
type: Species
has only substance units: false
initial amount: NaN
name: GLRX2

metaR GLYCt
reactant: MODEL1310110008#
name: glycerol transport via channel
is: SBO:0000185
product: MODEL1310110008#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
kinetic law: MODEL1310110008#
is described by: ECO:0000000
fast: false

metaM spmd e
is: C00315
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
constant: false
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: Spermidine
has only substance units: false
is: SBO:0000247
is: CHEBI:57834
is: HMDB01257

metaM dgcholcoa x
initial amount: NaN
is: C05461
is: SBO:0000247
boundary condition: false
is: HMDB06897
name: Chenodeoxyglycocholoyl-CoA
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24?,25-,26+,27?,28?,29?,30+,31+,34?,36+,37+,38?,42+,44-,45+/m0/s1 EHMN_ABBREVIATION: C05461
type: Species
constant: false

metaR r1594
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110008#
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110008#_d71489d2_41a8_4cd7_bc8c_4d28ded5c995
name: _W74642_1_c
boundary condition: true
constant: false
type: Species
is encoded by: hsa:W74642
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM C02528 r
is: CHEBI:36234
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
type: Species
has only substance units: false
is: HMDB00518
boundary condition: false
initial amount: NaN
name: chenodeoxycholate

metaR PSERT
product: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110008#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.6.1.52
name: phosphoserine transaminase

http://identifiers.org/biomodels.db/MODEL1310110008#_b4575436_1f2b_467a_a911_cdd12b700cde
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
initial amount: NaN
has part: Q6FIH7
is: SBO:0000297
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:516
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_a046ebb0_bdd0_4627_9a67_384b228d997d
initial amount: NaN
is encoded by: hsa:2806
name: GOT2
is: SBO:0000252
has only substance units: false
boundary condition: true
is: P00505
initial concentration: NaN
type: Species
constant: false

metaM dmnoncoa x
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
type: Species
is: HMDB11604
initial amount: NaN
name: 4,8 dimethylnonanoyl-CoA
initial concentration: 1.0
boundary condition: false

metaM xoldiolone c
constant: false
is: CHEBI:28477
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB02197
has only substance units: false
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
initial amount: NaN
type: Species

metaM arachdcoa r
name: arachidonoyl-CoA(4-)
has only substance units: false
is: HMDB06523
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: CHEBI:57368
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_c628925a_2f16_470c_935f_1b374d5e17b5
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: ST3GAL3
is encoded by: hsa:6487
boundary condition: true

metaR KSItly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110008#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110008#
is described by: ECO:0000000
reversible: false
fast: false
name: keratan sulfate I transport, extracellular to lysosome
reactant: MODEL1310110008#

metaM pail5p hs c
is: SBO:0000247
is: CHEBI:57795
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
initial amount: NaN

metaR r1597
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110008#
type: Reaction

metaM nad r
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
is: CHEBI:57540
is: SBO:0000247
name: NAD(1-)
is: HMDB00902

http://identifiers.org/biomodels.db/MODEL1310110008#_a88c0f6f_2758_4ddc_affb_baf48ef84384
has only substance units: false
initial amount: NaN
is encoded by: hsa:1636
is: B4DKH4
name: ACE
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252

metaM hs deg19 l
is: HMDB01352
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: heparan sulfate, degradation product 19
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
is: CHEBI:17180
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_fafa85ca_36fd_4d48_8363_74a390c27d80
is: P10746
boundary condition: true
type: Species
has only substance units: false
name: UROS
is encoded by: hsa:7390
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN

metaR DHEASULT
type: Reaction
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (6783.1) or (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:1588921 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.8.2.14
modifier: MODEL1310110008#
is described by: ECO:0000269
reversible: false
name: Dehydroepiandrosterone sulfotransferase
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.4
is: SBO:0000176

metaR H3ETer
is: SBO:0000176
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
name: H3 phosphoethanolaminyl transferase, endoplasmic reticulum
reversible: false
product: MODEL1310110008#
modifier: MODEL1310110008#
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_d1253ce4_6f24_4ddb_b967_511884b0fce5
name: DLST
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:1743
is: P36957
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_a57d161b_452d_4e6c_8e23_83ba3422f4b8
name: SLC37A4
type: Species
is: SBO:0000252
boundary condition: true
is: A8K0S7
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:2542

http://identifiers.org/biomodels.db/MODEL1310110008#_0e9eb9d0_57f6_4542_a5f4_05e9fbe5acb9
type: Species
initial amount: NaN
is: Q9NWU1
constant: false
initial concentration: NaN
name: OXSM
has only substance units: false
is encoded by: hsa:54995
is: SBO:0000252
boundary condition: true

metaR r2401
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110008#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaM acgal l
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB00212
is: SBO:0000247
name: N-acetyl-D-galactosamine
is: CHEBI:28037

http://identifiers.org/biomodels.db/MODEL1310110008#_a33570ca_b876_4ece_b290_5c159ec0d3f3
name: ADH1B:ADH1C
is: SBO:0000297
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:126
constant: false
has part: P00326
type: Species

metaR FAOXC141C121x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C14:1-->C12:1)x
type: Reaction

metaM cs b l
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
constant: false
has only substance units: false
initial amount: NaN
is: HMDB02183
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:36005
is: SBO:0000247

metaM cs a deg5 l
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C23H36O24S CHARGE: -2
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
boundary condition: false
is: CHEBI:15936
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_a5ee1d53_039d_49bc_af88_11165721a9d1
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:1607
is: SBO:0000252
name: DGKB
boundary condition: true
initial amount: NaN
has only substance units: false

metaR LNSTLSr
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/5.4.99.7
reactant: MODEL1310110008#
reversible: false
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
name: lanosterol synthase
fast: false
is: SBO:0000176

metaR r1596
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110008#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#

metaR PCm
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.4.1.1
modifier: MODEL1310110008#
is described by: ECO:0000269
fast: false
name: pyruvate carboxylase
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
type: Reaction
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#

metaR CHOLt4
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
fast: false
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
reversible: true
product: MODEL1310110008#
reactant: MODEL1310110008#
name: choline, sodium cotransport

metaM dcsptn1coa c
is: C16173
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205483
is: HMDB06513
type: Species
constant: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_ff1c7dd6_92a3_4968_bfb3_ba66df17a641
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2747
has only substance units: false
name: GLUD2
type: Species
constant: false
initial amount: NaN
is: P49448

metaR FAOXC150m
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ
reversible: false
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000269
reactant: MODEL1310110008#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
name: Beta oxidation of long chain fatty acid (odd chain)
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176

metaR ADK3m
kinetic law: MODEL1310110008#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
product: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#
is: SBO:0000176
name: adentylate kinase (GTP)
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.10
reactant: MODEL1310110008#

metaR HESTRATRIOLte
product: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be exported NJ
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110008#
name: hydroxylated estrogen derivative transport
reactant: MODEL1310110008#
is described by: ECO:0000000

metaM CE2417 m
has only substance units: false
initial concentration: 1.0
is: HMDB11123
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
constant: false
is: CHEBI:28387

http://identifiers.org/biomodels.db/MODEL1310110008#_dd291418_9da2_48a0_a097_c40ca5cc487c
initial concentration: NaN
is encoded by: hsa:224
type: Species
is: P51648
name: ALDH3A2
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN

metaR C6DCc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoylcarnitine
type: Reaction

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

metaR r1014
fast: false
reactant: MODEL1310110008#
product: MODEL1310110008#
name: Postulated transport reaction
kinetic law: MODEL1310110008#
is: SBO:0000185
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
type: Reaction

metaR RE2660N
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/4.2.1.96
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
is: SBO:0000176
reversible: true
name: RE2660
modifier: MODEL1310110008#
fast: false

metaR r1599
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110008#
reversible: true
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_88c7f1a8_48cc_4c06_b424_168735f05d7e
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:10317
name: B3GALT5
boundary condition: true
constant: false

metaM arachdcoa m
is: HMDB06523
initial amount: NaN
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
name: arachidonoyl-CoA(4-)
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:57368

http://identifiers.org/biomodels.db/MODEL1310110008#_d90f9505_3e66_4d9a_92d8_6acf7ee174c6
has part: P09622
is: SBO:0000297
initial concentration: NaN
has part: P36957
has only substance units: false
type: Species
has part: Q02218
is encoded by: hsa:1738
name: DLD:DLST:OGDH:PDHX
constant: false
is encoded by: hsa:8050
boundary condition: true
has part: O00330
is encoded by: hsa:1743
is encoded by: hsa:4967
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_38517dd8_ab6a_4166_8289_6f5d06f8156c
name: HADHB
boundary condition: true
has only substance units: false
is: P55084
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3032
constant: false
is: SBO:0000252
type: Species

metaR FACOAL224
name: fatty-acid--CoA ligase
is: SBO:0000176
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR DOLPGT2 Uer
type: Reaction
product: MODEL1310110008#
reactant: MODEL1310110008#
reversible: false
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
modifier: MODEL1310110008#
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.1.265
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD

http://identifiers.org/biomodels.db/MODEL1310110008#_a3957307_b81d_4a36_9b7a_c564d554c077
initial amount: NaN
initial concentration: NaN
type: Species
name: _AI620219_1_m
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:AI620219
has only substance units: false

metaR r1013
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
name: Transport reaction
reactant: MODEL1310110008#
is: SBO:0000185
reversible: false
product: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR r1598
reactant: MODEL1310110008#
reversible: true
product: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaM phaccoa c
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
constant: false
name: phenylacetyl-CoA(4-)
is: HMDB06503
boundary condition: false
initial amount: NaN
is: CHEBI:57390

metaR FAOXC121C101m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:1-->C10:1)m
type: Reaction

metaR r0926
reversible: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
product: MODEL1310110008#
name: Postulated transport reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_a39cce34_99ac_4624_8180_2a6bc10b8367
initial concentration: NaN
initial amount: NaN
is: P31937
constant: false
is: SBO:0000252
is encoded by: hsa:11112
type: Species
boundary condition: true
name: HIBADH
has only substance units: false

metaM sarcs m
initial concentration: 1.0
is: C00213
type: Species
boundary condition: false
is: CHEBI:15611
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
is: SBO:0000247
name: Sarcosine
constant: false
is: HMDB00271
initial amount: NaN

metaM etfrd m
notes: FORMULA: RH2 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
type: Species
name: Electron transfer flavoprotein reduced
boundary condition: false
has only substance units: false
is: HMDB00145
constant: false
is: CHEBI:17263
initial amount: NaN

metaM hpyr x
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
boundary condition: false
has only substance units: false
constant: false
name: 3-hydroxypyruvate
is: HMDB01352
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17180
is: SBO:0000247

metaM leuktrF4 c
constant: false
is: CHEBI:27491
initial amount: NaN
type: Species
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
name: leukotriene F4
initial concentration: 1.0
has only substance units: false
is: HMDB06465
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_9d8199f5_ecdb_4904_9589_fb193e61324b
is encoded by: hsa:4830
initial amount: NaN
has only substance units: false
name: NME1
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: P15531

http://identifiers.org/biomodels.db/MODEL1310110008#_171ed116_d355_4177_acfa_0a2d43c28323
type: Species
initial concentration: NaN
has only substance units: false
name: _J03866_1_m
is encoded by: hsa:J03866
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252

metaM adrn c
is: CHEBI:53487
name: adrenic acid
initial concentration: 1.0
is: HMDB02226
constant: false
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
initial amount: NaN

metaR r2518
product: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:
kinetic law: MODEL1310110008#
type: Reaction
reversible: true
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1
reactant: MODEL1310110008#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_6a7fbd08_db0d_4cac_b019_95e5eae7264b
boundary condition: true
name: SLC35D1
initial amount: NaN
has only substance units: false
is: Q9NTN3
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:23169
initial concentration: NaN

metaM itp n
name: ITP(3-)
is: CHEBI:57614
is: SBO:0000247
type: Species
is: HMDB00189
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_80e9848d_908a_42d0_959e_4d071a41ce9f
is: SBO:0000252
name: NADSYN1
initial concentration: NaN
constant: false
is: Q6IA69
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:55191

metaR FAOXTC142TC122m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C14:2-->C12:2)m
type: Reaction

metaM 5adtststerone c
is: CHEBI:16330
type: Species
has only substance units: false
name: 17beta-hydroxy-5alpha-androstan-3-one
initial amount: NaN
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB02961
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_515ed9c4_f5e5_4f8a_9cc8_4b1aba7bddcc
has only substance units: false
type: Species
is: Q9BWD1
is encoded by: hsa:39
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: ACAT2
boundary condition: true

metaM cbasp e
type: Species
boundary condition: false
constant: false
is: CHEBI:32814
notes: FORMULA: C5H6N2O5 CHARGE: -2
initial amount: NaN
is: C00438
name: N-Carbamoyl-L-aspartate
is: SBO:0000247
initial concentration: 1.0
is: HMDB00828
has only substance units: false

metaR HSD17B2r
is version of: http://identifiers.org/ec-code/1.1.1.62
type: Reaction
modifier: MODEL1310110008#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110008#
fast: false
name: 17-beta-hydroxysteroid dehydrogenase
is: SBO:0000176
product: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (3294.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 4 AUTHORS: PMID:8099587 NOTES:microsomal NAD as cofactor HSD type 2 recheck/confirm comparmentalization - type 1: cytosol, types 2,3: microsomes NJ

metaR r2519
is described by: ECO:0000000
name: Utilized transport
reactant: MODEL1310110008#
reversible: true
type: Reaction
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
product: MODEL1310110008#
is: SBO:0000185
fast: false

metaM gullac r
initial amount: NaN
is: CHEBI:17587
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
is: HMDB03466
constant: false
type: Species
is: SBO:0000247
name: L-gulono-1,4-lactone

metaM o2 r
has only substance units: false
is: SBO:0000247
is: HMDB01377
is: C00007
name: O2
is: CHEBI:15379
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007

metaM ksi pre12 g
initial amount: NaN
is: C00130
has only substance units: false
constant: false
is: HMDB00175
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
name: keratan sulfate I biosynthesis, precursor 12
type: Species
is: CHEBI:58053

metaM m4masn g
notes: FORMULA: C46H77N2O35X CHARGE: 0
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
boundary condition: false
is: SBO:0000247
is: C05881

http://identifiers.org/biomodels.db/MODEL1310110008#_da3f6ff1_323d_4fc6_a461_92ff3d46edea
has only substance units: false
constant: false
initial concentration: NaN
has part: P00338
name: LDHA:LDHB
type: Species
boundary condition: true
has part: P07195
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:3939
is encoded by: hsa:3945

http://identifiers.org/biomodels.db/MODEL1310110008#_58af73ce_872d_419d_9e70_056312e75d69
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:55350
is: SBO:0000252
name: VNN3
initial concentration: NaN
boundary condition: true

metaR biomass reaction
name: biomass_reaction
fast: false
is: SBO:0000185
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
kinetic law: MODEL1310110008#
reversible: false
type: Reaction
reactant: MODEL1310110008#
product: MODEL1310110008#

metaM HC01408 m
is: SBO:0000247
name: 3-Oxohexanoyl-CoA
constant: false
is: CHEBI:27648
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
initial concentration: 1.0

metaR r0707
reversible: true
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777 NOTES:
is described by: ECO:0000000
type: Reaction
name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate phosphohydrolase (alkaline optimum) Folate biosynthesis EC:3.1.3.1
fast: false
product: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.168

http://identifiers.org/biomodels.db/MODEL1310110008#_1b37ccda_ce12_4566_9074_e7f451006a1c
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:6508
is: SBO:0000252
name: SLC4A3
boundary condition: true
initial concentration: NaN
constant: false

metaR C161CRN2t
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
kinetic law: MODEL1310110008#
name: C161 transport into the mitochondria
is: SBO:0000185
reactant: MODEL1310110008#
reversible: false
modifier: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000269
fast: false

metaM adrn e
boundary condition: false
initial concentration: 1.0
name: adrenic acid
is: CHEBI:53487
has only substance units: false
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
is: HMDB02226

http://identifiers.org/biomodels.db/MODEL1310110008#_61904c25_a0ec_46c5_9917_2fdd4eab632a
constant: false
name: B4GALT2
type: Species
boundary condition: true
is: O60909
is: SBO:0000252
is encoded by: hsa:8704
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaM nadph r
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: CHEBI:57783
is: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00221
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaR r2516
is described by: ECO:0000000
kinetic law: MODEL1310110008#
is: SBO:0000185
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110008#
product: MODEL1310110008#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:

metaR 5HLTDL
is: SBO:0000176
modifier: MODEL1310110008#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.1.1.28
name: 5-Hydroxy-L-tryptophan decarboxy-lyase
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:1540578 NOTES:SAB
product: MODEL1310110008#
fast: false

metaR r0818
fast: false
is: SBO:0000185
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
is described by: ECO:0000000
reversible: false
type: Reaction
name: Transport reaction
product: MODEL1310110008#
reactant: MODEL1310110008#

metaR GLNtN1
is: SBO:0000185
kinetic law: MODEL1310110008#
is described by: ECO:0000269
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110008#
product: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
name: Glutamine transport (Na, H coupled)

metaM sbt D c
name: D-glucitol
is: HMDB00247
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
is: CHEBI:17924
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR MI134P4P
is: SBO:0000176
name: inositol-1,3,4-trisphosphate 4-phosphatase
type: Reaction
product: MODEL1310110008#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110008#_fb477c81_10dd_43a6_b176_3117ec50eb91
name: SLC6A8
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6535
is: B4DIA3
initial amount: NaN
boundary condition: true

metaR r0706
is version of: http://identifiers.org/ec-code/1.3.99.10
product: MODEL1310110008#
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
is described by: ECO:0000000
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
type: Reaction
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM acgal c
initial concentration: 1.0
is: CHEBI:28037
is: HMDB00212
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: N-acetyl-D-galactosamine
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_84ef0657_b7de_4071_a20b_8b5f53743ede
boundary condition: true
initial concentration: NaN
name: ALG8
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:79053
is: SBO:0000252
has only substance units: false
is: A6NDW6

metaM 5adtststerone e
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
name: 17beta-hydroxy-5alpha-androstan-3-one
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: HMDB02961
initial concentration: 1.0
boundary condition: false
is: CHEBI:16330

metaR HXPRT
modifier: MODEL1310110008#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.8
reactant: MODEL1310110008#
product: MODEL1310110008#
reversible: false
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
kinetic law: MODEL1310110008#

metaR r0817
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#
is: SBO:0000185
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.41
fast: false

metaM nad m
is: C00003
constant: false
initial amount: NaN
name: Nicotinamide adenine dinucleotide
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3305
initial concentration: 1.0
type: Species
is: CHEBI:57540
is: SBO:0000247
is: HMDB00902

metaR TRDRm
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES:NCD
is: SBO:0000176
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110008#
is described by: ECO:0000269
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.8.1.9
name: thioredoxin reductase (NADPH)
reactant: MODEL1310110008#

metaM dcsptn1coa m
is: C16173
type: Species
is: HMDB06513
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
has only substance units: false
constant: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205483
initial amount: NaN

metaM ahcys m
constant: false
type: Species
is: HMDB00939
is: SBO:0000247
is: CHEBI:16680
is: C00021
name: S-Adenosyl-L-homocysteine
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_9bf3d910_d3e8_45e7_9ae9_e0591a574035
initial amount: NaN
is encoded by: hsa:3158
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is: P54868
type: Species
constant: false
name: HMGCS2

metaR HISTAtu
name: Histamine uniport
reactant: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000269
reversible: true
type: Reaction
modifier: MODEL1310110008#

metaR HSAT3ly
kinetic law: MODEL1310110008#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
is described by: ECO:0000000
type: Reaction
product: MODEL1310110008#
reversible: false
fast: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
is: SBO:0000185

metaR PSt3
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000269
fast: false
reactant: MODEL1310110008#
type: Reaction
is: SBO:0000185
name: phosphatidylserine transport
product: MODEL1310110008#
reversible: true

metaM sebacid x
initial amount: NaN
initial concentration: 1.0
name: sebacicacid
notes: FORMULA: C10H16O4 CHARGE: -2
constant: false
boundary condition: false
is: C08277
is: HMDB00792
is: SBO:0000247
has only substance units: false
type: Species

metaR ORNt3m
reactant: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110008#
reversible: true
name: ornithine mitochondrial transport via proton antiport
is: SBO:0000185
fast: false
product: MODEL1310110008#

metaM C02528 c
has only substance units: false
boundary condition: false
name: chenodeoxycholate
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
constant: false
is: CHEBI:36234
is: SBO:0000247
is: HMDB00518
type: Species
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_6ce5bd66_6df9_490d_89e6_2b8450a8a40b
initial amount: NaN
name: ENTPD1
type: Species
is encoded by: hsa:953
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q86VV3
boundary condition: true

metaR r1177
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110008#
is: SBO:0000176
name: EC:3.1.1.13
product: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
type: Reaction
fast: false

metaR ACOAO7p
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
reversible: false
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
is described by: ECO:0000269
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_ba1e88c2_21a0_4050_a93b_41596bde86ef
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AA081045
type: Species
name: _AA081045_1_c
constant: false
is: SBO:0000252
initial amount: NaN

metaR PGCD
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.95
notes: GENE_ASSOCIATION: (26227.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
modifier: MODEL1310110008#
reactant: MODEL1310110008#
product: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
type: Reaction
name: phosphoglycerate dehydrogenase
is: SBO:0000176
is described by: ECO:0000269

metaR FAOXC101C8x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8:0)x
type: Reaction

metaM Lkynr c
type: Species
boundary condition: false
is: HMDB00684
is: SBO:0000247
has only substance units: false
name: L-kynurenine
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
initial amount: NaN
constant: false
is: CHEBI:16946
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_5bd603a3_2e4b_402c_9cc6_567d7fd1f148
initial concentration: NaN
is: Q9NY28
has only substance units: false
type: Species
constant: false
name: GALNT8
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:26290

metaR r0819
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is described by: ECO:0000000
modifier: MODEL1310110008#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110008#
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#

metaR IPDDIx
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.3.2
name: isopentenyl-diphosphate D-isomerase
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
reversible: true
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110008#
product: MODEL1310110008#
modifier: MODEL1310110008#

metaM tdec4ecoa m
is: C08277
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
boundary condition: false
name: trans4decenoylcoa
constant: false
has only substance units: false
is: HMDB00792
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR S6T12g
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110008#
reactant: MODEL1310110008#

metaM tetdecdicoa m
boundary condition: false
constant: false
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
is: HMDB02288
initial concentration: 1.0
initial amount: NaN
name: 5,8-tetradecadienoylcoa

metaM arachdcoa x
boundary condition: false
is: CHEBI:57368
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: arachidonoyl-CoA(4-)
type: Species
is: HMDB06523

metaR D LACt2
type: Reaction
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
is described by: ECO:0000269
reactant: MODEL1310110008#
is: SBO:0000185
reversible: true
name: D-lactate transport via proton symport
kinetic law: MODEL1310110008#
product: MODEL1310110008#
modifier: MODEL1310110008#
fast: false

metaR C10OHc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdecanoylcarnitinec
type: Reaction

metaM glyc R m
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
name: D-glycerate
is: CHEBI:16659
is: HMDB00139

http://identifiers.org/biomodels.db/MODEL1310110008#_5118e13d_98d0_4cca_88bb_ae9652d1b761
boundary condition: true
is: SBO:0000252
is encoded by: hsa:130367
initial amount: NaN
constant: false
initial concentration: NaN
name: SGPP2
type: Species
is: Q8IWX5
has only substance units: false

metaM ksii core2 deg7 l
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C44H73N4O30X CHARGE: 0
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:57455
initial amount: NaN
is: HMDB01354
constant: false
name: keratan sulfate II (core 2-linked), degradation product 7

metaM sarcs c
type: Species
initial concentration: 1.0
is: CHEBI:3513
is: SBO:0000247
is: HMDB00271
initial amount: NaN
has only substance units: false
boundary condition: false
name: Sarcosine
notes: FORMULA: C3H7NO2 CHARGE: 0
constant: false
is: C00213

metaR FAOXC123x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)x
type: Reaction

metaR r1019
type: Reaction
reactant: MODEL1310110008#
is: SBO:0000185
kinetic law: MODEL1310110008#
reversible: true
fast: false
product: MODEL1310110008#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is described by: ECO:0000000

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaM docohepcoa m
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
name: 2,4,7,10,13,16,19-docosaheptenoylcoa
constant: false
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_89805926_3c40_403f_bfe2_15d063a44833
initial concentration: NaN
constant: false
boundary condition: true
is: B8ZZR8
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:79017
is: SBO:0000252
name: GGCT

metaR MACACI
name: maleylacetoacetate isomerase
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.5.1.18
type: Reaction
product: MODEL1310110008#
reversible: false
is described by: ECO:0000269
fast: false
modifier: MODEL1310110008#
is: SBO:0000176

metaM abt c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
type: Species
is: CHEBI:18403
name: L-arabinitol
has only substance units: false
boundary condition: false
is: HMDB01851
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_8e966c49_f82b_4de7_81b9_566d16fe7cbe
is: Q9BW60
name: ELOVL1
has only substance units: false
is encoded by: hsa:64834
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_0c81499a_0ba6_45e5_acda_0e56a12b5d90
has only substance units: false
is encoded by: hsa:AI656480
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: _AI656480_1_m
constant: false
boundary condition: true
type: Species

metaR LEUKTRB4t
is: SBO:0000185
product: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
is described by: ECO:0000000
name: leukotriene B4 transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110008#

metaM HC01223 m
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
is: CHEBI:57340
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
boundary condition: false

metaM ditp n
has only substance units: false
name: dITP(4-)
is: SBO:0000247
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
is: CHEBI:61382
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB03537
initial amount: NaN

metaR RE1448N
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
reversible: true
fast: false
is: SBO:0000176
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
name: RE1448
is described by: ECO:0000000
product: MODEL1310110008#
type: Reaction

metaR EX hyptaur LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hypotaurine
type: Reaction

metaR RE1807M
name: RE1807
fast: false
is: SBO:0000176
reactant: MODEL1310110008#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
modifier: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110008#

metaR FAOXC140
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is: SBO:0000176
product: MODEL1310110008#
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
is described by: ECO:0000269

metaM o2 x
is: CHEBI:15379
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
initial amount: NaN
name: O2
has only substance units: false
is: C00007
is: SBO:0000247
is: HMDB01377
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_d7d7a2fa_0d1f_4045_8b6c_6ea6de35dcb1
initial amount: NaN
initial concentration: NaN
constant: false
is: G0W2N5
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:6563
type: Species
name: SLC14A1

metaR r0722
product: MODEL1310110008#
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/4.2.3.12
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110008#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211

http://identifiers.org/biomodels.db/MODEL1310110008#_12f06d00_c528_4f91_8a1b_ff716377328d
has only substance units: false
is: A0S0A7
name: NOS3
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:4846
constant: false
is: SBO:0000252

metaR SCP21cx
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of phytanoylcoa from cytosol to peroxisomes.
type: Reaction

metaM tettet6coa x
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
boundary condition: false
constant: false
is: HMDB06516
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/47205481
initial amount: NaN
initial concentration: 1.0
is: C16171
has only substance units: false
name: tetracosatetraenoyl coenzyme A

metaR STRDNCt
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110008#
name: fatty acid transport via diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110008#
is described by: ECO:0000000
reactant: MODEL1310110008#
type: Reaction

metaR r1453
is described by: ECO:0000000
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reversible: true
is: SBO:0000176
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
type: Reaction
fast: false

metaR ILEtec
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
type: Reaction
product: MODEL1310110008#
name: L-isoleucine transport via diffusion (extracellular to cytosol)
is described by: ECO:0000269
reversible: true

metaR PSFLIPm
reactant: MODEL1310110008#
is described by: ECO:0000269
type: Reaction
reversible: false
is: SBO:0000185
name: phosphatidylserine flippase
fast: false
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
is version of: http://identifiers.org/ec-code/3.6.3.1
product: MODEL1310110008#
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#

metaR LPS3
name: lipase
product: MODEL1310110008#
is: SBO:0000176
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.23
is described by: ECO:0000000
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (11343.1) or (11343.2) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.23 Confidence Level: 4 AUTHORS: PMID:9495531 NOTES:NJ
fast: false

metaR LNELDCt
product: MODEL1310110008#
is: SBO:0000185
name: fatty acid transport via diffusion
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_d6e2fb82_547a_4818_a088_a0e98f471ce9
name: PIGP
type: Species
is encoded by: hsa:51227
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_62635d78_3c63_4d84_988e_db3eae1f00d9
type: Species
boundary condition: true
is: Q99714
constant: false
name: HSD17B10
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3028
initial amount: NaN

metaR TAGt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110008#
is described by: ECO:0000000
name: triacylglycerol transport
fast: false
type: Reaction
product: MODEL1310110008#
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_18f4db5c_4e71_4d53_a5e8_64f76b980858
has only substance units: false
initial amount: NaN
is encoded by: hsa:84129
name: ACAD11
boundary condition: true
is: Q709F0
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110008#_4db1f27b_4173_4f45_aba0_29be08fcef43
boundary condition: true
type: Species
is: Q75T13
name: PGAP1
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:80055

metaR r2521
product: MODEL1310110008#
reactant: MODEL1310110008#
name: Utilized transport
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:

metaM ach n
name: acetylcholine
is: SBO:0000247
is: CHEBI:15355
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00895

metaM HC01115 c
constant: false
initial concentration: 1.0
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
name: NeuNGc
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:29025
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_16d5c61b_c9dd_4136_9da5_347e8b7233d2
constant: false
boundary condition: true
is: Q96DU7
type: Species
is: SBO:0000252
is encoded by: hsa:80271
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: ITPKC

http://identifiers.org/biomodels.db/MODEL1310110008#_fa93198e_a6cf_4195_af0a_6b0d4d1d9b20
is: C9JC79
is encoded by: hsa:6342
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
type: Species
name: SCP2

metaR r0723
reversible: false
reactant: MODEL1310110008#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.41
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110008#
fast: false
product: MODEL1310110008#
is described by: ECO:0000000
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110008#

metaR AG13T18g
reactant: MODEL1310110008#
is described by: ECO:0000000
kinetic law: MODEL1310110008#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110008#
product: MODEL1310110008#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaR AGTim
product: MODEL1310110008#
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.6.1.44
type: Reaction
fast: false
reversible: false

metaR r1301
is: SBO:0000185
fast: false
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
name: Vesicular transport
reversible: false
is described by: ECO:0000000
product: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR r0610
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110008#
name: CTP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251,PMID:193556,PMID:2987258,PMID:6091737 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110008#

metaM xoldiolone r
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
is: HMDB02197
has only substance units: false
is: CHEBI:28477
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
is: SBO:0000247

metaR DSAT
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110008#
fast: false
is: SBO:0000176
name: dihydrosphingosine N-acyltransferase
type: Reaction
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
reactant: MODEL1310110008#

metaR r1454
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
reversible: false
fast: false
product: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_95b4504a_ecab_4dbe_be37_7ac519156f7f
constant: false
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:BF195998
initial amount: NaN
is: SBO:0000252
name: _BF195998_1_x

metaM glyc R c
initial concentration: 1.0
name: D-glycerate
type: Species
is: SBO:0000247
is: HMDB00139
has only substance units: false
boundary condition: false
is: CHEBI:16659
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
constant: false
initial amount: NaN

metaR CSPG Etly
is described by: ECO:0000000
type: Reaction
reversible: false
reactant: MODEL1310110008#
product: MODEL1310110008#
name: chondroitin sulfate E transport, extracellular to lysosome
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is: SBO:0000185

metaR r0834
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110008#
is described by: ECO:0000000

metaR S23T4g
is version of: http://identifiers.org/ec-code/2.4.99.4
fast: false
reactant: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
is: SBO:0000176
name: beta-galactoside alpha-2,3-sialyltransferase
modifier: MODEL1310110008#
reversible: false
is described by: ECO:0000000
product: MODEL1310110008#

metaR HISCAT1
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_02ca5c28_efd2_41be_960d_6d7692638d3e
constant: false
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
name: SLC8A3
is: SBO:0000252
is: P57103
initial amount: NaN
is encoded by: hsa:6547

metaM thcholstoic r
is: HMDB03873
boundary condition: false
is: CHEBI:18402
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722

metaM cspg e e
type: Species
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
constant: false
boundary condition: false
is: HMDB00630
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16040
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
is: SBO:0000247

metaR r2520
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
kinetic law: MODEL1310110008#
fast: false
type: Reaction
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000000
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110008#_398e7e99_f323_4112_9d0d_9a7a343e3c84
initial amount: NaN
is: P30038
constant: false
is encoded by: hsa:8659
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
name: ALDH4A1
initial concentration: NaN

metaM leuktrC4 c
is: CHEBI:57973
has only substance units: false
name: leukotriene C4(2-)
initial amount: NaN
boundary condition: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
initial concentration: 1.0
constant: false
is: HMDB01198
is: SBO:0000247
type: Species

metaR r0611
name: ITP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251 NOTES:
modifier: MODEL1310110008#
fast: false
reversible: true
kinetic law: MODEL1310110008#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.2.3.1
product: MODEL1310110008#

metaR r0724
is version of: http://identifiers.org/ec-code/2.7.1.33
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110008#
product: MODEL1310110008#
fast: false
reversible: true
reactant: MODEL1310110008#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:

metaR r1156
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110008#
is: SBO:0000176
product: MODEL1310110008#
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110008#_d324ca19_3ca9_48b4_9d46_493741cc381c
name: PNPLA3
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q9NST1
has only substance units: false
constant: false
is encoded by: hsa:80339
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_62fd4458_3ad2_4bc6_8746_d95273d78d44
type: Species
name: KL
is encoded by: hsa:9365
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is: Q9UEF7
initial concentration: NaN

metaR RE3243R
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000000
product: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
type: Reaction
reversible: true
name: RE3243
is: SBO:0000176
modifier: MODEL1310110008#

metaM glutcoa m
type: Species
is: CHEBI:57378
has only substance units: false
boundary condition: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
is: SBO:0000247
name: glutaryl-CoA(5-)
is: HMDB01339
initial concentration: 1.0
initial amount: NaN
constant: false

metaM crm hs r
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: N-acylsphingosine
constant: false
type: Species
is: CHEBI:52639
initial amount: NaN

metaR ITPtn
name: ITP nuclear transport
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110008#
product: MODEL1310110008#
reversible: true
is: SBO:0000185

metaM creat c
name: creatine
is: HMDB00064
constant: false
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16919
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_fe494e9b_97be_462e_b065_afdf03f5ad3d
name: IMPA1
constant: false
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: B7Z6Q4
is encoded by: hsa:3612

metaM 3mob m
has only substance units: false
initial concentration: 1.0
is: CHEBI:11851
name: 3-methyl-2-oxobutanoate
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: HMDB00019
boundary condition: false
initial amount: NaN

metaM ksi deg3 l
type: Species
boundary condition: false
has only substance units: false
is: HMDB00573
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
name: keratan sulfate I, degradation product 3
is: CHEBI:30825
initial concentration: 1.0

metaR LPS2
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
reversible: false
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.1.34
modifier: MODEL1310110008#
is: SBO:0000176
kinetic law: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110008#
name: lipase

metaR C180CRNt
is: SBO:0000185
kinetic law: MODEL1310110008#
name: C180 transport into the mitochondria
is described by: ECO:0000269
fast: false
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
type: Reaction
modifier: MODEL1310110008#
reactant: MODEL1310110008#
reversible: false

metaM CE2838 e
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: C01936
name: maltononaose
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
constant: false
has only substance units: false

metaM 3ivcoa m
boundary condition: false
name: 3-hydroxyisovalerylcoa
constant: false
is: http://identifiers.org/pubchem.compound/11966188
is: C05998
initial amount: NaN
type: Species
is: HMDB06870
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM nrpphrsf c
constant: false
type: Species
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/123747
initial concentration: 1.0
is: HMDB02062
name: Sulfate derivative of norepinephrine
is: SBO:0000247
initial amount: NaN

metaR SCP21x
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
is version of: http://identifiers.org/ec-code/2.3.1.176
is: SBO:0000185
modifier: MODEL1310110008#
reversible: true
type: Reaction
reactant: MODEL1310110008#
is described by: ECO:0000269
product: MODEL1310110008#
name: Sterol carrier protein 2
kinetic law: MODEL1310110008#
fast: false

metaR It
type: Reaction
modifier: MODEL1310110008#
is: SBO:0000185
product: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
name: Iodide uniport
kinetic law: MODEL1310110008#
reversible: true
fast: false
is described by: ECO:0000269

metaR EX ddece1crn
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dodecenoyl carnitine
type: Reaction

metaM hs deg9 l
name: heparan sulfate, degradation product 9
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
has only substance units: false
type: Species
initial amount: NaN
is: HMDB06355
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:18268

metaR r0084
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.42
type: Reaction
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
fast: false
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:

metaR C181OHc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecenoylcarnitinec
type: Reaction

metaR LDH D
type: Reaction
fast: false
reversible: true
product: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
reactant: MODEL1310110008#
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000304
name: D-lactate dehydrogenase
is version of: http://identifiers.org/ec-code/1.1.2.4

metaM leuktrC4 e
is: SBO:0000247
boundary condition: false
is: CHEBI:57973
name: leukotriene C4(2-)
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB01198
type: Species
initial amount: NaN

metaM ksii core4 pre5 g
is: SBO:0000247
is: CHEBI:58053
is: HMDB00175
boundary condition: false
type: Species
name: keratan sulfate II biosynthesis, precursor 5
initial amount: NaN
constant: false
notes: FORMULA: C69H112N6O48X CHARGE: -1
has only substance units: false
is: C00130
initial concentration: 1.0

metaR FAOXC164x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)x
type: Reaction

metaR C141CPT1
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecenoylcarnitine
type: Reaction

metaR r0726
reactant: MODEL1310110008#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.1.33
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
product: MODEL1310110008#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
modifier: MODEL1310110008#
reversible: true
fast: false

metaR r2525
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
product: MODEL1310110008#
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000185
type: Reaction
fast: false

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_6bd5a555_2e04_4c45_85cc_455610b10809
is: P33402
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:2977
name: GUCY1A2
is: SBO:0000252

metaM cbasp c
is: C00438
constant: false
type: Species
name: N-Carbamoyl-L-aspartate
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
is: HMDB00828
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:32814

metaR FAOXC1811601m
reversible: false
kinetic law: MODEL1310110008#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110008#
reactant: MODEL1310110008#
name: Beta oxidation fatty acid
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110008#
is: SBO:0000176
fast: false

metaM L2aadp m
is: CHEBI:58672
type: Species
initial concentration: 1.0
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00510
name: L-2-aminoadipate(1-)
initial amount: NaN

metaR DOLPGT1 Uer
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10359825 NOTES:EC 2.4.1.- NCD
is version of: http://identifiers.org/ec-code/2.4.1.267
reactant: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
type: Reaction
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
fast: false

metaM chsterol c
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00067
has only substance units: false
initial amount: NaN
is: CHEBI:16113
name: cholesterol
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_fbf57807_445c_4928_9205_6f74d39c1c07
name: GUSB
boundary condition: true
initial amount: NaN
is encoded by: hsa:2990
is: SBO:0000252
initial concentration: NaN
constant: false
is: P08236
has only substance units: false
type: Species

metaR r0083
is described by: ECO:0000000
fast: false
reactant: MODEL1310110008#
product: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.42
type: Reaction
kinetic law: MODEL1310110008#
reversible: true
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42

metaM dad 2 e
boundary condition: false
is: CHEBI:17256
is: SBO:0000247
has only substance units: false
name: 2-deoxyadenosine
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
initial amount: NaN
is: HMDB00101
initial concentration: 1.0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_9eef7376_e15f_409e_b9e1_70dcb57efe5f
is encoded by: hsa:3251
constant: false
is: P00492
name: HPRT1
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_13d9d127_4eb2_47f9_8f7c_a0f68f6c096e
is: P28329
is encoded by: hsa:1103
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
name: CHAT

metaR TYMSFt
is: SBO:0000185
fast: false
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000
name: Tyramine O-sulfate transport (diffusion)
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate

http://identifiers.org/biomodels.db/MODEL1310110008#_6521e891_4a79_4610_9789_e53c0c014ec3
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
name: COX7A1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1346
is: P24310
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_d2003a8d_f5aa_4597_b5f7_229f1d02a31f
type: Species
is: SBO:0000252
is encoded by: hsa:215
initial amount: NaN
constant: false
has only substance units: false
name: ABCD1
boundary condition: true
initial concentration: NaN
is: P33897

metaR EX c101crn
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decenoyl carnitine
type: Reaction

metaM C02470 c
initial amount: NaN
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
name: Xanthurenic acid
is: http://identifiers.org/pubchem.compound/5485
is: HMDB00881
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
is: C02470
has only substance units: false

metaM nrpphrsf e
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
is: HMDB02062
has only substance units: false
is: http://identifiers.org/pubchem.compound/123747
boundary condition: false
name: Sulfate derivative of norepinephrine
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
is: SBO:0000247

metaM HC01410 m
constant: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
is: CHEBI:28706
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
name: (2E)-Hexenoyl-CoA

metaM arachcrn c
name: arachidyl carnitine
initial amount: NaN
is: HMDB06460
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
boundary condition: false

metaM ksi pre29 g
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:28067
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
type: Species
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 29
constant: false

metaR r0838
is: SBO:0000185
modifier: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
reversible: true
kinetic law: MODEL1310110008#
is described by: ECO:0000000
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.2.4
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
name: Free diffusion
fast: false

metaR r0086
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
fast: false
kinetic law: MODEL1310110008#
is described by: ECO:0000000
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
modifier: MODEL1310110008#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.3
is: SBO:0000176
product: MODEL1310110008#
type: Reaction

metaM gsn c
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
name: Guanosine
is: C00387
is: CHEBI:16750
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
constant: false
is: HMDB00133

metaM CE2422 m
constant: false
is: HMDB11123
type: Species
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
is: CHEBI:28387
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR TDP
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: thiamin pyrophosphatase
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:2171493,PMID:8522961 NOTES:_01-25-05 IT AMF
type: Reaction
reversible: false

metaR r1302
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110008#
fast: false
is described by: ECO:0000000
product: MODEL1310110008#
type: Reaction
name: Vesicular transport
kinetic law: MODEL1310110008#

metaR r0728
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110008#_85b530e7_03ff_437f_b567_5405fd4840c9
boundary condition: true
has only substance units: false
name: ADCY3
is: B3KT86
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:109

http://identifiers.org/biomodels.db/MODEL1310110008#_54267899_56a4_4ab7_bc5e_53f4e642c1f8
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
name: ATP5J
is encoded by: hsa:522
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_e3636131_c400_42e2_a0d4_5f4f4956d6c7
has only substance units: false
name: BCKDHA
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:593
type: Species
boundary condition: true
initial amount: NaN
is: B4DP47
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_75cfa35d_5c7c_4870_aa2b_3bec2c6c2726
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:171425
name: CLYBL

metaR RETNt
reversible: true
type: Reaction
reactant: MODEL1310110008#
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
kinetic law: MODEL1310110008#
name: retinoic acid transport

metaR GLYLEUHYDROc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Glycylleucine in the small intestine for cellular uptake
type: Reaction

metaM dad 2 c
boundary condition: false
type: Species
is: CHEBI:17256
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
name: 2-deoxyadenosine
initial amount: NaN
initial concentration: 1.0
is: HMDB00101

http://identifiers.org/biomodels.db/MODEL1310110008#_fdee7f39_26c9_4db6_8d21_c09f46941376
is: P50747
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:3141
is: SBO:0000252
name: HLCS
boundary condition: true
type: Species

metaR r0085
is: SBO:0000176
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
type: Reaction
modifier: MODEL1310110008#
reversible: false
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110008#
is described by: ECO:0000000
reactant: MODEL1310110008#
fast: false

metaM ksi deg34 l
constant: false
notes: FORMULA: C76H126N5O59S1 CHARGE: -1
is: HMDB01354
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:57455
name: keratan sulfate I, degradation product 34
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_ebbada28_cfc1_47cc_951a_f0c91a72abf7
is encoded by: hsa:10786
type: Species
initial amount: NaN
has only substance units: false
constant: false
name: SLC17A3
is: O00476
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR FAOXC122m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaM Sfglutth c
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:57688
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
name: S-formylglutathionate(1-)
is: HMDB01550

metaM Lcyst c
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C3H6NO5S CHARGE: -1 INCHI: InChI=1S/C3H7NO5S/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/p-1/t2-/m0/s1 EHMN_ABBREVIATION: C00506
is: SBO:0000247
is: HMDB02757
is: CHEBI:58090
has only substance units: false
name: L-cysteate(1-)
type: Species

metaR r2526
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
kinetic law: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#

metaM CE5869 e
is: SBO:0000247
is: HMDB02710
initial amount: NaN
constant: false
name: lysyl-proline
type: Species
boundary condition: false
is: CHEBI:27485
has only substance units: false
notes: FORMULA: C11H22N3O3 CHARGE: 1 INCHI: InChI=1/C11H21N3O3/c12-6-2-1-4-8(13)10(15)14-7-3-5-9(14)11(16)17/h8-9H,1-7,12-13H2,(H,16,17)/p+1/t8-,9-/m1/s1 EHMN_ABBREVIATION: CE5869
initial concentration: 1.0

metaR r0836
modifier: MODEL1310110008#
fast: false
is: SBO:0000185
product: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.16
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is described by: ECO:0000000
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaR TRPHYDRO2
modifier: MODEL1310110008#
is: SBO:0000176
product: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.14.16.4
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
reversible: false
type: Reaction
fast: false
is described by: ECO:0000269

metaM bilglcur c
boundary condition: false
is: CHEBI:57767
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
constant: false
name: mono(glucosyluronic acid)bilirubin(2-)

metaR FAOXC24C22x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Fatty acid beta oxidation(C24-->C22)x
type: Reaction

metaM gly e
is: C00037
notes: FORMULA: C2H5NO2 CHARGE: 0
is: HMDB00123
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: Glycine
is: CHEBI:3339
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_e288daf2_2ed9_42ae_bd63_564f358a7825
is: P33261
name: CYP2C19
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:1557

metaR r0946
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110008#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110008#
fast: false

metaM ksi deg35 l
is: HMDB00143
initial amount: NaN
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
constant: false
boundary condition: false
name: keratan sulfate I, degradation product 35
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110008#_181cc883_3e46_4106_ba9d_04e880c67adf
constant: false
initial concentration: NaN
is: Q13615
name: MTMR3
is: SBO:0000252
type: Species
is encoded by: hsa:8897
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_bb86eda3_4b01_4d2e_9533_5edbc16f830b
type: Species
has only substance units: false
is: P00813
name: ADA
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:100

metaR C226CRNt
is: SBO:0000185
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000000
reversible: false
type: Reaction
product: MODEL1310110008#
fast: false
name: C226 transport into the mitochondria

metaR r0617
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reactant: MODEL1310110008#
is: SBO:0000176
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2

metaR SPHK21c
reactant: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction
is: SBO:0000176
reversible: false
fast: false
name: sphingosine kinase 2
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.7.1.91
kinetic law: MODEL1310110008#
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_83327efa_418d_49f3_a921_6dd1176deb2e
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
name: _AA664770_1_m
is encoded by: hsa:AA664770

metaM ach e
is: HMDB00895
initial amount: NaN
name: acetylcholine
boundary condition: false
has only substance units: false
is: CHEBI:15355
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_5106d792_1b47_4a1a_b085_5e8b85e96d18
constant: false
initial concentration: NaN
is: SBO:0000252
is: P30049
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:513
name: ATP5D

metaR ADEt
type: Reaction
reversible: true
modifier: MODEL1310110008#
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
name: adenine reversible transport, cytosol
reactant: MODEL1310110008#
fast: false

metaR FACOAL80i
modifier: MODEL1310110008#
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
fast: false
name: fatty-acid--CoA ligase (octanoate)
kinetic law: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
reversible: false
type: Reaction
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_c39d5955_7801_45eb_8363_7b58110e7c84
boundary condition: true
type: Species
initial amount: NaN
is: P35218
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:763
constant: false
has only substance units: false
name: CA5A

http://identifiers.org/biomodels.db/MODEL1310110008#_9c9b9cc7_c065_4d18_9a1d_fcacb4e1d8ba
type: Species
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:AA977580
initial amount: NaN
name: _AA977580_1_c
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_6d6758dd_42d3_477e_bb1f_ba561d22afaf
constant: false
is: Q16222
is encoded by: hsa:6675
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
name: UAP1
initial amount: NaN

metaM gullac c
type: Species
name: L-gulono-1,4-lactone
is: CHEBI:17587
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
is: HMDB03466
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_56b31305_e7c9_42bd_a889_4872ff22aa3c
is: SBO:0000252
constant: false
name: PCBD1
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:5092

metaM ksi pre5 g
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C101H164N7O75SX CHARGE: -2
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 5
constant: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_be28283b_904b_47a1_b71b_4d1af64c213a
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: NDUFV3
is: P56181
initial concentration: NaN
constant: false
is encoded by: hsa:4731

metaR r1010
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Postulated transport reaction
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110008#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_34ebbee5_438a_4e93_a221_611d4e3ce10e
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:2876
boundary condition: true
is: P07203
constant: false
name: GPX1

metaM udpgal g
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
name: UDP-D-galactose(2-)
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: HMDB00302
constant: false
initial concentration: 1.0
is: CHEBI:58439
type: Species

metaM 3mob c
constant: false
is: CHEBI:11851
is: HMDB00019
has only substance units: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: 3-methyl-2-oxobutanoate
is: SBO:0000247
type: Species

metaR ASPDTDe
reactant: MODEL1310110008#
is: SBO:0000185
reversible: true
fast: false
name: D-aspartate transport, extracellular
is described by: ECO:0000134
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: D-aspartate may exit by diffusion or require specific transporters. NOTES:D-aspartate may exit by diffusion or require specific transporters.
type: Reaction
kinetic law: MODEL1310110008#

metaM bilglcur e
is: SBO:0000247
is: CHEBI:57767
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial concentration: 1.0
boundary condition: false
type: Species
name: mono(glucosyluronic acid)bilirubin(2-)

http://identifiers.org/biomodels.db/MODEL1310110008#_37880a48_f6a1_471a_b190_e4f3ee9f1944
name: PDE8A
type: Species
is encoded by: hsa:5151
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR r0081
product: MODEL1310110008#
fast: false
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.5.1.12
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110008#

metaM ditp c
initial concentration: 1.0
name: dITP(4-)
is: CHEBI:61382
boundary condition: false
is: HMDB03537
is: SBO:0000247
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
initial amount: NaN
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_7c082871_b58c_4bff_af87_d0948a26f905
name: SLC24A3
is: SBO:0000252
has only substance units: false
is: Q9HC58
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:57419
constant: false

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaM arachcrn m
initial concentration: 1.0
constant: false
is: HMDB06460
has only substance units: false
name: arachidyl carnitine
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3

metaR r1459
is described by: ECO:0000000
reversible: true
name: Transport reaction
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
fast: false
product: MODEL1310110008#
type: Reaction

metaR C142CPT1
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecadienoylcarnitine
type: Reaction

metaR r0944
product: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
fast: false
name: Active transport
type: Reaction
reactant: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110008#

metaR Coqe
product: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
name: Transport of q10
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
fast: false
is: SBO:0000185

metaR RE2677G
fast: false
is described by: ECO:0000000
product: MODEL1310110008#
reversible: false
name: RE2677
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:
type: Reaction
reactant: MODEL1310110008#
is: SBO:0000176
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_3a7f9636_ed5d_47f6_be48_841babbb1ee1
constant: false
boundary condition: true
is encoded by: hsa:3098
is: SBO:0000252
type: Species
is: Q59FD4
initial concentration: NaN
initial amount: NaN
name: HK1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_1e023b0a_3dee_4a29_a968_00a8ce8e1b6c
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: CHST5
constant: false
type: Species
is encoded by: hsa:23563
is: SBO:0000252

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_c4121088_f7a5_4835_8fbe_8f9f22ed1444
is encoded by: hsa:39
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: ACAT2
is: Q9BWD1

http://identifiers.org/biomodels.db/MODEL1310110008#_8287cb5b_8816_4054_8a1c_66b7772b51a3
name: PPAP2C
is encoded by: hsa:8612
is: SBO:0000252
has only substance units: false
is: E9PAY8
initial concentration: NaN
constant: false
boundary condition: true
type: Species
initial amount: NaN

metaM udpgal e
is: SBO:0000247
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
constant: false
is: HMDB00302
is: CHEBI:58439
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
name: UDP-D-galactose(2-)
initial concentration: 1.0

metaM ksi pre13 g
name: keratan sulfate I biosynthesis, precursor 13
boundary condition: false
is: CHEBI:58053
is: HMDB00175
is: C00130
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
notes: FORMULA: C143H231N10O111S3X CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110008#_60cbe3b4_f93f_4fe0_8d7c_9acb42095796
name: SDHB
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is: P21912
constant: false
initial concentration: NaN
is encoded by: hsa:6390

metaM 3mob e
is: HMDB00019
is: CHEBI:11851
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: 3-methyl-2-oxobutanoate
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
type: Species
constant: false

metaM gacpail hs c
constant: false
boundary condition: false
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: glucosaminyl-acylphosphatidylinositol
type: Species
is: SBO:0000247
is: C00092
is: HMDB01401
is: CHEBI:61548

http://identifiers.org/biomodels.db/MODEL1310110008#_d62b2d9f_2494_4f53_bfca_0f89940f47a3
is: P30043
boundary condition: true
has only substance units: false
constant: false
type: Species
is encoded by: hsa:645
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: BLVRB

metaR THRGLYexR
product: MODEL1310110008#
name: L-threonine/glycine reversible exchange
is described by: ECO:0000304
reactant: MODEL1310110008#
type: Reaction
fast: false
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110008#
reversible: true

metaR LDH L
fast: false
reactant: MODEL1310110008#
modifier: MODEL1310110008#
is: SBO:0000176
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.27
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
reversible: true
type: Reaction
name: L-lactate dehydrogenase
is described by: ECO:0000000
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_98640a61_93f1_4ff3_832f_23755faeacc5
constant: false
is: Q14376
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
name: GALE
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2582

metaM CE2435 m
name: trans,cis-deca-2,4-dienoyl-CoA
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
initial amount: NaN
type: Species
is: CHEBI:57795
constant: false
is: SBO:0000247
has only substance units: false

metaR r0942
kinetic law: MODEL1310110008#
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
is: SBO:0000185

metaR FAOXC18C18OHm
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18-->C18OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_aecc79fd_db4d_4b17_850c_357b3a4d1bcb
constant: false
is: Q9BYZ2
name: LDHAL6B
type: Species
is encoded by: hsa:92483
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_f408fe74_faae_4f31_9639_410fb767e899
initial concentration: NaN
boundary condition: true
has only substance units: false
name: _AI769281_1_e
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:AI769281

metaM dlnlcg c
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
is: CHEBI:53486
boundary condition: false
is: HMDB02925
name: dihomo-gamma-linolenic acid (n-6)
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN

metaM dlnlcg e
is: HMDB02925
constant: false
name: dihomo-gamma-linolenic acid (n-6)
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
is: CHEBI:53486
initial amount: NaN

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaM g2m8masn r
initial concentration: 1.0
has only substance units: false
is: C05874
constant: false
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C82H137N2O65X CHARGE: 0
boundary condition: false

metaR r2419
fast: false
reversible: true
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000185
type: Reaction
product: MODEL1310110008#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaM 3ivcoa c
constant: false
name: 3-hydroxyisovalerylcoa
has only substance units: false
type: Species
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/11966188
is: HMDB06870
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: C05998

metaR RE2677E
kinetic law: MODEL1310110008#
is described by: ECO:0000000
fast: false
product: MODEL1310110008#
reversible: false
name: RE2677
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
type: Reaction
reactant: MODEL1310110008#
is: SBO:0000176

metaM sphmyln hs c
has only substance units: false
notes: FORMULA: CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
is: HMDB02704
is: CHEBI:21338
boundary condition: false
name: sphmyln_hs[c]
type: Species
constant: false
initial amount: NaN

metaR r0830
reactant: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.16
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
kinetic law: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#

metaR DHORTS
reversible: true
name: dihydroorotase
fast: false
is: SBO:0000176
reactant: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
type: Reaction
modifier: MODEL1310110008#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.3.2
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_71f0e189_8758_493d_8cd2_110163ad870d
is encoded by: hsa:9091
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is: Q9BRB3
has only substance units: false
is: SBO:0000252
boundary condition: true
name: PIGQ

metaM creat e
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16919
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: HMDB00064
constant: false
is: SBO:0000247
name: creatine

metaR ORNTArm
product: MODEL1310110008#
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (4942.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.13 Confidence Level: 4 AUTHORS: PMID:9514741 NOTES:kh 1/7/03 SAB m
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.13
name: ornithine transaminase reversible (m)
reversible: true
fast: false
is: SBO:0000176

metaR r0614
product: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
fast: false
reversible: true
reactant: MODEL1310110008#
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
is: SBO:0000176
kinetic law: MODEL1310110008#
type: Reaction

metaM udpgal c
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00302
initial amount: NaN
name: UDP-D-galactose(2-)
is: CHEBI:58439
type: Species
is: SBO:0000247

metaR FE2tm
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10383398,PMID:12755454 NOTES:TDV Lange H, 1999.
name: iron (II) transport
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110008#
reversible: false
is described by: ECO:0000000
product: MODEL1310110008#

metaM gly c
is: SBO:0000247
initial concentration: 1.0
name: Glycine
has only substance units: false
is: C00037
constant: false
is: HMDB00123
is: CHEBI:3339
boundary condition: false
type: Species
notes: FORMULA: C2H5NO2 CHARGE: 0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_9b48834d_9b44_457e_a001_03ad963bf80f
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AL050025
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: _AL050025_1_c

metaR Ser Thrtg
name: Ser/Thr transport (from golgi to lysosome)
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110008#_bf9e8ad6_e0ed_4c6a_b986_4e9c643a8af1
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
name: BDH1
is encoded by: hsa:622
boundary condition: true
has only substance units: false
constant: false

metaR HGNTOR
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
reversible: false
modifier: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.5
type: Reaction
reactant: MODEL1310110008#
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_e055deaa_d967_43d6_8e5d_a038dd8067bc
is encoded by: hsa:9023
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is: O95992
name: CH25H
has only substance units: false

metaR MTHFDm
fast: false
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
modifier: MODEL1310110008#
is described by: ECO:0000269
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
reactant: MODEL1310110008#
is: SBO:0000176
kinetic law: MODEL1310110008#
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.9
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/6.3.4.3

http://identifiers.org/biomodels.db/MODEL1310110008#_695022fe_6cb2_4d36_ae48_7ada29301e94
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4696
is: O95167
type: Species
constant: false
name: NDUFA3
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR r0940
name: Free diffusion
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
reversible: true
type: Reaction
product: MODEL1310110008#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110008#_546850f4_cbad_42cd_aa1d_9d1947b4fd11
initial amount: NaN
has only substance units: false
is encoded by: hsa:410
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is: P15289
name: ARSA
initial concentration: NaN

metaR r0615
reversible: true
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.168
kinetic law: MODEL1310110008#
product: MODEL1310110008#
modifier: MODEL1310110008#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110008#_a5224615_2d5c_4776_8313_dc5f2bbc0477
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
name: ADCY8
is: Q4F7X0
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:114

metaR TETHEX3COAtx
is described by: ECO:0000000
reactant: MODEL1310110008#
fast: false
name: fatty acid intracellular transport
kinetic law: MODEL1310110008#
is: SBO:0000185
product: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true

metaR GLU5Km
name: glutamate 5-kinase (m)
is: SBO:0000176
product: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
type: Reaction
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.2.1.41
modifier: MODEL1310110008#
reactant: MODEL1310110008#
reversible: false
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 2.7.2.11 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m

metaR r0616
is described by: ECO:0000000
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
product: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000176
modifier: MODEL1310110008#
reversible: true
fast: false

metaR RE0944E
is version of: http://identifiers.org/ec-code/3.2.1.1
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
product: MODEL1310110008#
name: RE0944
fast: false
reactant: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#

metaR FAOXC164m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaR S3TASE2ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110008#
product: MODEL1310110008#
fast: false
reversible: true
name: N-acetylglucosamine-3-sulfatase, lysosomal
type: Reaction
is: SBO:0000176
reactant: MODEL1310110008#

metaR r0941
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
reversible: true
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110008#
is described by: ECO:0000000
name: Free diffusion

metaR HDDACBP
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM hpyr c
has only substance units: false
name: 3-hydroxypyruvate
constant: false
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17180
is: HMDB01352
type: Species
boundary condition: false

metaR HTDCRNe
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-tetradecanoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_93dd5cdf_8f95_4fad_a2a5_3d4a4096caca
initial concentration: NaN
is: Q6FGA0
type: Species
is encoded by: hsa:9167
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
name: COX7A2L

http://identifiers.org/biomodels.db/MODEL1310110008#_88a0535f_d11a_4980_a597_ef4d1cf4b743
is: P43166
name: CA7
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:766
has only substance units: false
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110008#_41372ce7_3d23_40e2_908e_8713ef7a1e6a
initial amount: NaN
is: Q8N4A0
is: SBO:0000252
is encoded by: hsa:8693
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
constant: false
name: GALNT4

metaR EX asp D LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Aspartate exchange
type: Reaction

metaR METATB0tc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Methionine into the intestinal cells by ATB0 transporter
type: Reaction

metaM mev R c
name: (R)-mevalonate
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:36464
constant: false
initial concentration: 1.0
is: HMDB00227
boundary condition: false
type: Species

metaM ptth c
is: HMDB03426
initial concentration: 1.0
name: pantetheine
is: SBO:0000247
is: CHEBI:16753
type: Species
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN

metaR VACCCRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: transport into the mitochondria (carnitine)
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
reversible: false
product: MODEL1310110008#
modifier: MODEL1310110008#

metaR G14T4g
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
reactant: MODEL1310110008#

metaM ppi r
initial concentration: 1.0
is: SBO:0000247
name: Diphosphate
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
initial amount: NaN
is: C00013
boundary condition: false
constant: false
is: CHEBI:33019
has only substance units: false

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaM dag hs c
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:18035
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
has only substance units: false
name: diglyceride

metaM malcoa e
name: malonyl-CoA(4-)
boundary condition: false
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
initial concentration: 1.0
constant: false
type: Species
is: HMDB01175
has only substance units: false
initial amount: NaN
is: CHEBI:57384
is: SBO:0000247

metaM octe5coa m
constant: false
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: 5-octenoylcoa
notes: FORMULA: C29H44N7O17P3S CHARGE: -4

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaR RE2649M
product: MODEL1310110008#
fast: false
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (10965.1) or (11332.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:IT - fixed proton
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110008#
name: RE2649
is version of: http://identifiers.org/ec-code/3.1.2.2
kinetic law: MODEL1310110008#

metaM prgnlones c
boundary condition: false
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00774
notes: FORMULA: C21H31O5S CHARGE: -1 INCHI: InChI=1S/C21H32O5S/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19H,5-12H2,1-3H3,(H,23,24,25)/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: CE4764
name: pregnenolone sulfate
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:35420

metaR UDPDOLPT U
is described by: ECO:0000000
is: SBO:0000176
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (uterus)
reversible: false
product: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.1.117
reactant: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:10359825,PMID:8280060 NOTES:NCD

metaM retinal 11 cis c
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
initial concentration: 1.0
type: Species
is: HMDB02152
boundary condition: false
is: CHEBI:16066
constant: false
initial amount: NaN
is: SBO:0000247
name: 11-cis-retinal
has only substance units: false

metaM digalsgalside hs c
is: C06127
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/8384
constant: false
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
type: Species
name: Digalactosylceramidesulfate
initial amount: NaN

metaR r2200
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110008#
reversible: true
type: Reaction
product: MODEL1310110008#
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5

metaM gly m
is: C00037
name: Glycine
is: HMDB00123
initial concentration: 1.0
constant: false
is: CHEBI:15428
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_406b136f_3eba_41df_8e29_977cd3519213
is: Q5SYN6
is encoded by: hsa:6581
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
constant: false
name: SLC22A3
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_2899ae6e_f352_43da_af1c_33c6a735cc8c
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:1119
name: CHKA
boundary condition: true
type: Species
initial concentration: NaN
constant: false

metaR G14T19g
product: MODEL1310110008#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
reversible: false
reactant: MODEL1310110008#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD

metaR FAOXC15C13m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C15-->C13)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_02a6ad62_6915_44be_9d90_a159738bef0e
name: FPGT
is: O14772
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:8790
initial concentration: NaN
boundary condition: true
constant: false

metaR FAOXC163Gm
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

metaM estrones c
is: CHEBI:60050
has only substance units: false
name: estrone 3-sulfate(1-)
notes: FORMULA: C18H21O5S CHARGE: -1 INCHI: InChI=1S/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/p-1/t14-,15-,16+,18+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00961 EHMN_ABBREVIATION: C02538
type: Species
boundary condition: false
is: HMDB01425
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_15f83519_6a3a_4539_afa9_7b427d786cb0
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: MAN1A1
is: P33908
constant: false
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:4121

metaR URIDK2m
name: uridylate kinase (dUMP), mitochondrial
reactant: MODEL1310110008#
fast: false
is described by: ECO:0000134
type: Reaction
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
kinetic law: MODEL1310110008#
product: MODEL1310110008#

metaR GGH 7DHFe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
type: Reaction
reactant: MODEL1310110008#
fast: false
product: MODEL1310110008#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110008#
name: Gamma-glutamyl hydrolase (7DHF), extracellular
modifier: MODEL1310110008#
reversible: false
is: SBO:0000176

metaM 2dp6mep m
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
name: 2-Decaprenyl-6-methoxyphenol
is: CHEBI:50774
is: SBO:0000247
notes: FORMULA: C57H88O2 CHARGE: 0 INCHI: InChI=1S/C57H88O2/c1-45(2)23-13-24-46(3)25-14-26-47(4)27-15-28-48(5)29-16-30-49(6)31-17-32-50(7)33-18-34-51(8)35-19-36-52(9)37-20-38-53(10)39-21-40-54(11)43-44-55-41-22-42-56(59-12)57(55)58/h22-23,25,27,29,31,33,35,37,39,41-43,58H,13-21,24,26,28,30,32,34,36,38,40,44H2,1-12H3/b46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+,54-43+
constant: false

metaR BTNt2
kinetic law: MODEL1310110008#
name: Biotin reversible transport via proton symport
modifier: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
fast: false
reactant: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_c5a6b6bf_e97e_426d_8142_d6ab61e6f010
boundary condition: true
is: SBO:0000252
name: GALNT9
constant: false
is: Q9HCQ5
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:50614
initial concentration: NaN

metaR EX ptdca LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentadecanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_257e0bb9_41be_4393_92e2_381998ca61b3
name: SULT2A1
initial concentration: NaN
constant: false
is encoded by: hsa:6822
boundary condition: true
is: SBO:0000252
is: Q06520
type: Species
initial amount: NaN
has only substance units: false

metaM sebacid c
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
is: C08277
name: sebacicacid
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00792
notes: FORMULA: C10H16O4 CHARGE: -2

metaM orn m
type: Species
is: HMDB00214
is: CHEBI:46912
boundary condition: false
is: C01602
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
name: Ornithine
initial amount: NaN
constant: false
initial concentration: 1.0

metaM etfox m
is: HMDB00145
boundary condition: false
notes: FORMULA: R CHARGE: 0
is: SBO:0000247
name: Electron transfer flavoprotein oxidized
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17263
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_fe86a116_b75f_41fe_a402_f3dc305fecdc
has only substance units: false
is encoded by: hsa:10327
boundary condition: true
constant: false
name: AKR1A1
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

metaM malcoa c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: Malonyl-CoA
has only substance units: false
is: C00083
constant: false
type: Species
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: HMDB01175
is: CHEBI:57384
initial amount: NaN

metaR r0339
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.2.22
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
product: MODEL1310110008#
reversible: false
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
kinetic law: MODEL1310110008#
fast: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_e4e17eac_ac05_42b4_bfd1_abf441e532a0
is encoded by: hsa:5295
is: SBO:0000297
constant: false
has part: E7EX19
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
name: PIK3CD:PIK3R1
type: Species

metaR XYLtly
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
name: Xylose efflux from lysosome
reactant: MODEL1310110008#
type: Reaction
fast: false
kinetic law: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110008#

metaM digalsgalside hs e
has only substance units: false
is: C06127
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/8384
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
is: SBO:0000247
name: Digalactosylceramidesulfate
initial amount: NaN
constant: false
boundary condition: false

metaR ITCOAL1m
modifier: MODEL1310110008#
fast: false
is: SBO:0000176
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
reversible: true
reactant: MODEL1310110008#
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/6.2.1.4

metaR DRPA
name: deoxyribose-phosphate aldolase
kinetic law: MODEL1310110008#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110008#
fast: false
product: MODEL1310110008#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:

metaR COQ5m
fast: false
name: Ubiquinone biosynthesis methyltransferase COQ5
kinetic law: MODEL1310110008#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:_2.1.1.- IT
type: Reaction
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_34f7fe6c_c5ad_460f_bd05_059f819303b7
has part: P23921
constant: false
has only substance units: false
name: RRM1:RRM2
has part: P31350
type: Species
initial amount: NaN
is encoded by: hsa:6240
is encoded by: hsa:6241
is: SBO:0000297
initial concentration: NaN
boundary condition: true

metaR HS2ly
modifier: MODEL1310110008#
name: heparan-N-sulfatase, lysosomal
is: SBO:0000176
product: MODEL1310110008#
reversible: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.10.1.1
fast: false

metaR BTNPLm
type: Reaction
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
fast: false
is: SBO:0000176
modifier: MODEL1310110008#
reversible: false
is described by: ECO:0000000
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/6.3.4.10
reactant: MODEL1310110008#

metaM ttdca e
boundary condition: false
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
is: CHEBI:30807
name: tetradecanoate (n-C14:0)
is: C06424
is: HMDB00806
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_0b31adb9_9b19_4c56_aea9_45252877736f
has only substance units: false
is: SBO:0000252
is: Q9Y2D0
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:11238
name: CA5B

metaM uacgam c
constant: false
boundary condition: false
type: Species
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
initial amount: NaN
is: CHEBI:57705
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
initial concentration: 1.0
is: SBO:0000247
is: HMDB00290
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_0c3369ac_a15e_4f67_95a9_4a2e4abccc2c
initial concentration: NaN
is encoded by: hsa:4830
has only substance units: false
type: Species
is: SBO:0000297
boundary condition: true
constant: false
initial amount: NaN
name: NME1:NME2

metaM estrones e
is: CHEBI:60050
initial concentration: 1.0
name: estrone 3-sulfate(1-)
has only substance units: false
notes: FORMULA: C18H21O5S CHARGE: -1 INCHI: InChI=1S/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/p-1/t14-,15-,16+,18+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00961 EHMN_ABBREVIATION: C02538
type: Species
is: HMDB01425
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247

metaM chsterol m
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00067
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: CHEBI:16113
name: cholesterol
initial amount: NaN
is: SBO:0000247
constant: false

metaM lys L m
is: SBO:0000247
name: L-lysinium(1+)
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: HMDB00182
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:32551

metaM 3htdcoa c
constant: false
type: Species
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
has only substance units: false
is: HMDB02014
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: (S)-3-Hydroxytetradecanoyl-CoA

metaM zymstnl r
initial amount: NaN
name: 5alpha-cholest-8-en-3beta-ol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB06841
is: CHEBI:16608

metaR LEUTA
reversible: true
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.6.1.42
reactant: MODEL1310110008#
name: leucine transaminase
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
is described by: ECO:0000269
kinetic law: MODEL1310110008#
product: MODEL1310110008#

metaM lys L n
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: CHEBI:32551
name: L-lysinium(1+)
initial amount: NaN
type: Species
is: HMDB00182
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_37a4da0d_9f12_414e_9e50_3e8acedd251d
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q13907
name: IDI1
is encoded by: hsa:3422
boundary condition: true
type: Species

metaM hdd2coa m
name: trans-Hexadec-2-enoyl-CoA
is: HMDB03945
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
is: C05272
constant: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: CHEBI:61526

metaR BILIRUBt2
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000185
reversible: true
modifier: MODEL1310110008#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
name: bilirubin transport via bicarbonate countertransport
reactant: MODEL1310110008#
type: Reaction

metaR GAPD
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
modifier: MODEL1310110008#
fast: false
is described by: ECO:0000134
name: glyceraldehyde-3-phosphate dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.12
reversible: true
product: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000176

metaR FRUt4
is described by: ECO:0000269
kinetic law: MODEL1310110008#
is: SBO:0000185
reversible: true
type: Reaction
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
product: MODEL1310110008#
name: D-fructose transport via sodium cotransport
fast: false
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_99d41fe1_92b2_4028_8746_26120869a2d7
has part: O43837
is encoded by: hsa:3420
has only substance units: false
is encoded by: hsa:3421
has part: P51553
is: SBO:0000297
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
type: Species
name: IDH3A:IDH3B:IDH3G

metaR EX tettet6 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosatetraenoic acid n-6 exchange
type: Reaction

metaM ppi n
initial amount: NaN
has only substance units: false
is: HMDB00250
is: CHEBI:33019
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
name: diphosphate(3-)
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_db8b8370_55b2_433d_abe6_326de46ec717
initial amount: NaN
name: SLC26A4
constant: false
is: O43511
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:5172
initial concentration: NaN
has only substance units: false

metaR FAOXC226205x
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110008#
product: MODEL1310110008#
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaR ORPT
fast: false
name: orotate phosphoribosyltransferase
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.2.10
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110008#
type: Reaction
reversible: true
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:

metaR SUCCt2m
type: Reaction
fast: false
name: succinate transport, mitochondrial
is: SBO:0000185
reversible: true
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110008#
is described by: ECO:0000269
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#

metaR G14Tg
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
product: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000269

metaM digalsgalside hs g
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
is: http://identifiers.org/pubchem.compound/8384
initial concentration: 1.0
name: Digalactosylceramidesulfate
constant: false
initial amount: NaN
is: SBO:0000247
is: C06127

metaR DECDICRNe
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of decadienoyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_988ce156_1fb4_4400_97c4_d4da01b189e9
name: _2544_1_c
has only substance units: false
is encoded by: hsa:2544
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR TETPENT6t
reversible: true
product: MODEL1310110008#
fast: false
name: fatty acid transport via diffusion
type: Reaction
kinetic law: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110008#

metaM ttdca c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
name: myristate
is: CHEBI:30807
type: Species
is: HMDB00806
is: SBO:0000247
boundary condition: false
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424

metaM ppi m
is: HMDB00250
is: CHEBI:33019
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
constant: false
is: SBO:0000247
is: C00013
initial concentration: 1.0
name: Diphosphate
has only substance units: false
boundary condition: false
initial amount: NaN

metaR r2201
kinetic law: MODEL1310110008#
product: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: MODEL1310110008#
reversible: true
is: SBO:0000185
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_37ef2bb0_dfab_4f9c_8593_93de681726e8
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1854
has only substance units: false
constant: false
name: DUT
is: P33316
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_e7cfa49c_eccc_4a57_b904_375b0b5875d8
constant: false
is: SBO:0000252
name: IDH3B
is encoded by: hsa:3420
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN

metaM em2emgacpail hs r
boundary condition: false
is: CHEBI:16240
initial concentration: 1.0
is: HMDB03125
has only substance units: false
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
initial amount: NaN
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_1ce07ead_c6ff_485a_bb12_94545e549d3d
is: SBO:0000252
is: Q6GTM5
name: SC5DL
initial concentration: NaN
type: Species
is encoded by: hsa:6309
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_d059e62c_cf9b_4eee_96b0_b57f697d109f
is: Q9UNU6
initial amount: NaN
boundary condition: true
constant: false
name: CYP8B1
is encoded by: hsa:1582
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_c7a55886_a89e_4a72_afa5_fccd79d6d96a
initial amount: NaN
is: Q9NZJ6
is: SBO:0000252
name: COQ3
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:51805
has only substance units: false

metaM chsterol r
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:16113
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: SBO:0000247
name: cholesterol
type: Species
is: HMDB00067

metaM CE2915 e
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041
constant: false
type: Species
notes: FORMULA: C44H60N7O11 CHARGE: -1 INCHI: InChI=1/C44H61N7O11/c1-5-26(4)37(44(61)62)49-40(57)34-14-10-22-51(34)43(60)31(19-20-35(53)54)46-41(58)36(25(2)3)48-38(55)32(24-27-11-7-6-8-12-27)47-39(56)33-13-9-21-50(33)42(59)30(45)23-28-15-17-29(52)18-16-28/h6-8,11-12,15-18,25-26,30-34,36-37,52H,5,9-10,13-14,19-24,45H2,1-4H3,(H,46,58)(H,47,56)(H,48,55)(H,49,57)(H,53,54)(H,61,62)/p-1/t26-,30-,31+,32+,33-,34+,36-,37-/m1/s1 EHMN_ABBREVIATION: CE2915
is: C01936
name: beta-casomorphin
has only substance units: false

metaM dcamp c
is: SBO:0000247
is: CHEBI:57567
initial concentration: 1.0
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
boundary condition: false
name: N6-(1,2-Dicarboxyethyl)-AMP
is: HMDB00536
initial amount: NaN
constant: false
is: C03794
type: Species
has only substance units: false

metaR TCHOLAte
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
kinetic law: MODEL1310110008#
is described by: ECO:0000000
fast: false

metaR HMGCOAtm
reversible: true
kinetic law: MODEL1310110008#
is: SBO:0000185
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110008#
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport

metaM hepcoa m
initial amount: NaN
name: heptanoylcoa
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB12969
constant: false
is: SBO:0000247
notes: FORMULA: C28H44N7O17P3S CHARGE: -4
has only substance units: false

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaR r0937
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110008#
name: Transport reaction
kinetic law: MODEL1310110008#
type: Reaction
product: MODEL1310110008#

metaR GUAt
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
type: Reaction
is: SBO:0000185
reactant: MODEL1310110008#
modifier: MODEL1310110008#
fast: false
is described by: ECO:0000269
reversible: true
name: Guanine transport
kinetic law: MODEL1310110008#
product: MODEL1310110008#

metaR r2202
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110008#
reversible: true
type: Reaction
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
product: MODEL1310110008#

metaM 10fthf7glu e
boundary condition: false
notes: FORMULA: C50H57N13O25 CHARGE: -8
initial concentration: 1.0
is: CHEBI:58190
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
is: HMDB00224
name: 10-formyltetrahydrofolate-[Glu](7)

http://identifiers.org/biomodels.db/MODEL1310110008#_472ee82a_dba5_4c15_a1e5_fd1b40387e12
name: AMY1A
initial concentration: NaN
type: Species
is: Q6NSB3
is encoded by: hsa:276
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false

metaR r0502
kinetic law: MODEL1310110008#
fast: false
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.113
reversible: true
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
product: MODEL1310110008#
reactant: MODEL1310110008#
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4

metaM biliverd c
constant: false
type: Species
is: CHEBI:57991
is: HMDB01008
boundary condition: false
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: biliverdin(2-)

http://identifiers.org/biomodels.db/MODEL1310110008#_7ea355df_4bde_4f8a_a983_73fad75e61e0
name: NSDHL
is: Q15738
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:50814
type: Species

metaR ACALDtr
fast: false
reactant: MODEL1310110008#
is: SBO:0000185
name: acetaldehyde reversible transport (ER)
product: MODEL1310110008#
reversible: true
kinetic law: MODEL1310110008#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:9028626 NOTES:

metaR EX tetdec2crn
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_9bafc22e_6e73_4a4f_b779_cafbee947393
is: SBO:0000252
boundary condition: true
is encoded by: hsa:56953
type: Species
is: Q9NPB1
initial amount: NaN
name: NT5M
initial concentration: NaN
has only substance units: false
constant: false

metaR NACHEX10ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
modifier: MODEL1310110008#
reversible: false
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_af574fa2_d40e_4443_bba3_f53257e37545
name: COX7B2
type: Species
boundary condition: true
has only substance units: false
is: Q8TF08
is: SBO:0000252
constant: false
is encoded by: hsa:170712
initial amount: NaN
initial concentration: NaN

metaR FAOXC241C221x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C24:1-->C22:1)x
type: Reaction

metaR r0936
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110008#
is: SBO:0000185
fast: false
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110008#
type: Reaction
name: Transport reaction

metaR CYSSNAT5tc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR RE2649C
is version of: http://identifiers.org/ec-code/3.1.2.2
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
reversible: true
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110008#
type: Reaction
fast: false
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000000
name: RE2649

http://identifiers.org/biomodels.db/MODEL1310110008#_a36e12fe_7503_4a0d_a0fd_353f317d4d3b
is encoded by: hsa:AD000092
constant: false
initial amount: NaN
has only substance units: false
name: _AD000092_1_c
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaM 3aib D m
name: D-3-Amino-isobutanoate
is: C03265
boundary condition: false
is: HMDB02299
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
type: Species

metaM CE2418 m
is: SBO:0000247
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
type: Species
initial concentration: 1.0
is: HMDB11123
constant: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
has only substance units: false
initial amount: NaN
is: CHEBI:28387
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_54649ded_865b_4993_9a65_e8f5124c286c
type: Species
is encoded by: hsa:2588
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is: P34059
name: GALNS
is: SBO:0000252
initial amount: NaN

metaR MTHFC
name: methenyltetrahydrofolate cyclohydrolase
reversible: true
modifier: MODEL1310110008#
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.5.4.9
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.5.1.5
reactant: MODEL1310110008#

metaR VALt5m
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
type: Reaction
reactant: MODEL1310110008#
name: Valine reversible mitochondrial transport
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_be641c38_3967_4872_bda1_5d64896de6a1
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is: P78330
has only substance units: false
name: PSPH
is encoded by: hsa:5723
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_e1022134_33e1_4b9f_a4f5_b743ea548093
is: Q96CD2
type: Species
name: PPCDC
is: SBO:0000252
is encoded by: hsa:60490
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR MI4PP
type: Reaction
reversible: false
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.3.25
name: myo-inositol 4-phosphatase
reactant: MODEL1310110008#
modifier: MODEL1310110008#
fast: false
is described by: ECO:0000269
is: SBO:0000176

metaR RE0383C
is version of: http://identifiers.org/ec-code/1.1.1.2
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
reversible: true
modifier: MODEL1310110008#
name: RE0383

metaM naglc2p U c
constant: false
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human uterine homolog
is: CHEBI:18278
has only substance units: false
is: SBO:0000247
notes: FORMULA: C1105H1810N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species

metaM decdicoa c
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
is: HMDB01168
constant: false
has only substance units: false
initial amount: NaN
name: decadienoylcoa

http://identifiers.org/biomodels.db/MODEL1310110008#_a78bdc63_b324_480a_b4a1_fcd4150a5b06
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
name: GBA
boundary condition: true
is encoded by: hsa:2629
constant: false

metaM HC02023 r
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:46898
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
name: Cholesterol-ester-ol
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1

metaR GBA
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ
reactant: MODEL1310110008#
reversible: false
product: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.2.1.45
name: Glucosylceramidase
is: SBO:0000176
type: Reaction
modifier: MODEL1310110008#
is described by: ECO:0000000

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

metaM fgam c
boundary condition: false
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
is: CHEBI:58426
type: Species
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB01308
has only substance units: false
is: C04376
constant: false

metaM cspg e l
is: HMDB02183
is: CHEBI:36005
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
type: Species
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
initial concentration: 1.0

metaM lys L c
initial concentration: 1.0
boundary condition: false
is: CHEBI:32551
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: HMDB00182
has only substance units: false
type: Species
name: L-lysinium(1+)
constant: false
initial amount: NaN
is: SBO:0000247

metaR r0829
is version of: http://identifiers.org/ec-code/4.1.1.37
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110008#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110008#
reactant: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_d92f5a1e_0c1e_4c1b_a1fc_15a493ddd625
boundary condition: true
initial amount: NaN
name: SULT1E1
constant: false
is encoded by: hsa:6783
is: P49888
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species

metaR r0504
reactant: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/2.3.3.10
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
product: MODEL1310110008#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

metaM HC00460 c
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
name: 2,5-dihydroxybenzoate
has only substance units: false
initial concentration: 1.0
is: CHEBI:58044
constant: false

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaM betald c
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
is: CHEBI:15710
boundary condition: false
name: betaine aldehyde
initial concentration: 1.0
is: HMDB01252
has only substance units: false
type: Species

metaR EX sprm LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_sprm(e)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_50e684fb_e617_4689_9f6f_552d4cd07274
is: SBO:0000252
initial amount: NaN
is: P83881
name: RPL36A
initial concentration: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:6173

metaM mi145p c
boundary condition: false
is: CHEBI:203600
type: Species
constant: false
has only substance units: false
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
initial concentration: 1.0
is: HMDB01498
is: SBO:0000247
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_7391b5f0_1eba_4487_87e7_982cc3e73964
name: PDE5A
is encoded by: hsa:8654
type: Species
has only substance units: false
constant: false
is: O76074
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR C6DCCACT
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of adipoyl carnitine into cytosol
type: Reaction

metaM ppi x
type: Species
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00250
name: Diphosphate
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial amount: NaN
boundary condition: false
is: C00013
is: CHEBI:33019
initial concentration: 1.0

metaR RE1447M
is: SBO:0000176
reactant: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.41
is described by: ECO:0000000
modifier: MODEL1310110008#
name: RE1447
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
type: Reaction
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110008#_47a0c6e8_8379_4fed_9ff9_ca124c4f2942
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: _U37519_1_m
is encoded by: hsa:U37519
type: Species
initial concentration: NaN

metaM ptth m
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: SBO:0000247
is: HMDB03426
name: pantetheine
initial amount: NaN
has only substance units: false
is: CHEBI:16753
boundary condition: false

metaM HC02217 c
name: prostaglandin-g2
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:27647
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
is: SBO:0000247

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_27c522f0_ab2f_4bbc_93e6_b2a32b2c912c
initial amount: NaN
is encoded by: hsa:3712
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is: B3KVI7
name: IVD
initial concentration: NaN
type: Species

metaR LEUKTRD4t
product: MODEL1310110008#
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
name: leukotriene D4 transport
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_5651dc4e_0983_4ef6_98d0_aa556df6aae5
initial concentration: NaN
type: Species
is: SBO:0000252
name: B3GNT7
is encoded by: hsa:93010
initial amount: NaN
has only substance units: false
constant: false
is: Q8NFL0
boundary condition: true

metaM lys L e
initial concentration: 1.0
boundary condition: false
is: CHEBI:32551
is: HMDB00182
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
type: Species
constant: false
initial amount: NaN
name: L-lysinium(1+)
has only substance units: false
is: SBO:0000247

metaM chsterol e
initial amount: NaN
constant: false
name: cholesterol
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00067
is: CHEBI:16113
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
boundary condition: false

metaR AGTix
reversible: false
reactant: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
name: alanine-glyoxylate transaminase (irreversible), (peroxisomal)
is version of: http://identifiers.org/ec-code/2.6.1.44
is described by: ECO:0000269
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (189.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:1703535,PMID:9038835,PMID:9783918 NOTES:NCD
fast: false
is: SBO:0000176

metaM hs deg16 l
is: HMDB02704
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
is: SBO:0000247
is: CHEBI:21338
constant: false
name: heparan sulfate, degradation product 16

metaR MTHFD
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
name: methylenetetrahydrofolate dehydrogenase (NADP)
is version of: http://identifiers.org/ec-code/1.5.1.5
reversible: true
product: MODEL1310110008#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
is described by: ECO:0000134
modifier: MODEL1310110008#

metaR FAOXC163x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_97f500fe_b047_4f21_810a_eec965c04f01
is: SBO:0000252
is encoded by: hsa:6549
type: Species
name: SLC9A2
is: Q9UBY0
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_2039f738_55a1_49a9_9001_acbc6b80b114
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:218
is: P30838
initial amount: NaN
type: Species
name: ALDH3A1

http://identifiers.org/biomodels.db/MODEL1310110008#_c9484cf7_4f59_4e8e_83ca_0efa668e572c
constant: false
name: IDH1
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:3417
type: Species
is: SBO:0000252
is: O75874

metaM cholate c
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00619
type: Species
name: Cholate
is: CHEBI:29747

metaM pydx5p e
is: CHEBI:597326
has only substance units: false
boundary condition: false
is: HMDB01491
notes: FORMULA: C8H8NO6P CHARGE: -2 INCHI: InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)/p-2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
is: SBO:0000247
initial amount: NaN
constant: false
name: pyridoxal 5'-phosphate(2-)
type: Species
initial concentration: 1.0

metaR RE1447N
is: SBO:0000176
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
kinetic law: MODEL1310110008#
is described by: ECO:0000000
name: RE1447
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110008#

metaM peamn c
type: Species
name: 2-phenylethanaminium
initial concentration: 1.0
is: HMDB12275
boundary condition: false
is: CHEBI:225237
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_1ff0e154_a180_4d3c_9552_cfbf0740e508
has only substance units: false
is: SBO:0000252
is: P46721
boundary condition: true
name: SLCO1A2
is encoded by: hsa:6579
initial amount: NaN
initial concentration: NaN
type: Species
constant: false

metaM chsterol l
initial amount: NaN
initial concentration: 1.0
is: HMDB00067
name: cholesterol
constant: false
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
boundary condition: false
has only substance units: false
is: CHEBI:16113
is: SBO:0000247

metaM hmbil c
type: Species
boundary condition: false
initial concentration: 1.0
name: Hydroxymethylbilane
initial amount: NaN
constant: false
is: C01024
is: HMDB01137
is: SBO:0000247
has only substance units: false
is: CHEBI:57845
notes: FORMULA: C40H38N4O17 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00628 EHMN_ABBREVIATION: C01024

metaR PETHCT
fast: false
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.7.14
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (5833.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.14 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110008#
name: phosphoethanolamine cytidyltransferase
is: SBO:0000176
reversible: false

metaR FAOXC16C14m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C14)m
type: Reaction

metaM ksi pre11 g
is: CHEBI:28067
type: Species
is: SBO:0000247
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 11
boundary condition: false
has only substance units: false
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
initial concentration: 1.0
constant: false

metaM n2m2mn l
has only substance units: false
is: C00022
notes: FORMULA: C42H71N3O31 CHARGE: 0
initial concentration: 1.0
is: HMDB00243
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)
boundary condition: false
is: CHEBI:15361
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/3324

metaR r0509
product: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
is described by: ECO:0000000
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110008#

metaM ksi deg40 l
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: keratan sulfate I, degradation product 40
initial concentration: 1.0
type: Species
is: HMDB00143
notes: FORMULA: C40H68N2O31 CHARGE: 0
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110008#_038eaa42_956d_4d9a_a0b4_abb6ff255d23
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:1491
is: P32929
initial amount: NaN
initial concentration: NaN
name: CTH
constant: false

metaR KHte
type: Reaction
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110008#
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110008#
reversible: true
name: KHte

metaR FAOXC121C10x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

metaR RE1517M
product: MODEL1310110008#
is described by: ECO:0000000
reactant: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
name: RE1517
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.13
is: SBO:0000176
reversible: true

metaM HC02217 e
is: SBO:0000247
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
name: prostaglandin-g2
initial amount: NaN
is: CHEBI:27647
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
type: Species

metaR ASCBt
type: Reaction
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000185
reversible: true
product: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
name: L-ascorbate transport via facilitated diffusion
is described by: ECO:0000000

metaR FAOXC2051843m
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of fatty acid
reactant: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction
product: MODEL1310110008#

metaR S6T13g
reactant: MODEL1310110008#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110008#
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110008#
reversible: false
is: SBO:0000176

metaR CYTK8n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110008#
is: SBO:0000176
name: cytidylate kinase (CMP,dATP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
is described by: ECO:0000269
reversible: true
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_a023c1f7_9626_4115_9a0f_d2dfe6ff681f
is: SBO:0000252
is encoded by: hsa:D29675
has only substance units: false
name: _D29675_1_e
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true

metaR HMGCOAtx
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
fast: false
reactant: MODEL1310110008#
product: MODEL1310110008#
kinetic law: MODEL1310110008#

metaR Q10H2e
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
reversible: true
is described by: ECO:0000134
name: transport of ubiquinol into lymph
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
fast: false

metaR r1167
fast: false
reactant: MODEL1310110008#
name: EC:2.3.1.26
product: MODEL1310110008#
type: Reaction
reversible: false
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
is: SBO:0000176
is described by: ECO:0000000

metaR BILDGLCURt
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
fast: false
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
reversible: true
product: MODEL1310110008#
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_27516591_b1ff_4a0e_bb0b_db379258c0e5
name: PFKM:PFKP
is encoded by: hsa:5213
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
constant: false
has part: P08237
boundary condition: true
has only substance units: false
type: Species

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

metaR GASNASEly
name: glycosylasparaginase, lysosomal
modifier: MODEL1310110008#
reactant: MODEL1310110008#
reversible: false
product: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.5.1.26

metaR FAOXC122x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)x
type: Reaction

metaR DGK2m
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.8 Confidence Level: 2 AUTHORS: NOTES:Added EC- JLR IT
name: deoxyguanylate kinase (dGMP:dATP) (mitochondrial)
product: MODEL1310110008#
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

metaM pydx5p c
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB01491
is: CHEBI:597326
is: C00018
notes: FORMULA: C8H8NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
initial concentration: 1.0
initial amount: NaN
constant: false
name: Pyridoxal 5'-phosphate

metaR FUMSO3tm
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110008#
reactant: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110008#
name: Fumarate:sulfite antiport, mitochondrial
is described by: ECO:0000269
is: SBO:0000185

metaR DLNLCGt
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
product: MODEL1310110008#
is: SBO:0000185
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_f3f451de_bbba_4903_bfb8_dc2dbccd547d
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:3038
name: HAS3
initial amount: NaN
constant: false
is: SBO:0000252
is: Q96RV2
initial concentration: NaN

metaR NACHEX19ly
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#

metaM cholate e
constant: false
type: Species
is: CHEBI:29747
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
name: Cholate
is: HMDB00619
is: SBO:0000247
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_4e5b89bd_1f0d_4b8f_9c38_5ee2f26c277e
is: SBO:0000252
is encoded by: hsa:2686
constant: false
is: A0PJJ9
name: GGT7
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_b02412d1_f1ff_4893_9469_26794cb65b00
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
name: NDUFS5
is encoded by: hsa:4725
type: Species
is: Q6IBA0

http://identifiers.org/biomodels.db/MODEL1310110008#_7f501d0a_4c4b_47bf_ad21_ebc95c9fcb7d
initial concentration: NaN
name: ALDH2
boundary condition: true
type: Species
is: P05091
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:217
is: SBO:0000252

metaR r2308
type: Reaction
kinetic law: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reversible: true
reactant: MODEL1310110008#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110008#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_d34f3260_28a0_4b07_afb0_aa0647393847
constant: false
is: A7E2E0
is: SBO:0000252
is encoded by: hsa:5293
initial concentration: NaN
name: PIK3CD
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_6e1ae942_bb49_4257_b367_a5da57684156
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
name: NT5C1B
initial amount: NaN
is encoded by: hsa:93034
boundary condition: true
is: Q96P26
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_c8091cae_a735_4b0e_872b_aaa68fd2c0c6
is: O76082
name: SLC22A5
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6584
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_2bcbe8e1_b62f_4c61_8ddb_3218367d830d
is: Q9P2X0
name: DPM3
initial concentration: NaN
is encoded by: hsa:54344
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false

metaM 3htdcoa m
type: Species
constant: false
initial concentration: 1.0
is: HMDB02288
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
has only substance units: false
boundary condition: false
name: (S)-3-Hydroxytetradecanoyl-CoA
is: SBO:0000247
initial amount: NaN

metaM bilglcur r
initial concentration: 1.0
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
constant: false
name: mono(glucosyluronic acid)bilirubin(2-)
is: CHEBI:57767
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_1ae9b99b_0b57_45ce_b820_1cccd05efa7a
is: SBO:0000252
type: Species
initial concentration: NaN
name: ACOT2
has only substance units: false
initial amount: NaN
is: P49753
is encoded by: hsa:10965
constant: false
boundary condition: true

metaR TTDCRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: transport into the mitochondria (carnitine)
product: MODEL1310110008#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110008#
is described by: ECO:0000000
modifier: MODEL1310110008#
reactant: MODEL1310110008#
reversible: false
fast: false

metaR r2309
fast: false
reversible: true
reactant: MODEL1310110008#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110008#_448914fa_4823_4aaf_8900_bc6273e293af
is: P08842
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:412
name: STS
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
type: Species

metaR EX adrn LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adrenic acid exchange
type: Reaction

metaM hdd2coa x
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:61526
name: (E)-hexadec-2-enoyl-CoA(4-)
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
type: Species
has only substance units: false
constant: false
is: HMDB03945
is: SBO:0000247

metaR r1007
product: MODEL1310110008#
kinetic law: MODEL1310110008#
name: Facilitated diffusion
reactant: MODEL1310110008#
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
is: SBO:0000185

metaR BILDGLCURtr
fast: false
type: Reaction
product: MODEL1310110008#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
is: SBO:0000185
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
name: glucuronidated compound transport

metaM L2aadp c
boundary condition: false
name: L-2-aminoadipate(1-)
has only substance units: false
type: Species
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:58672
is: HMDB00510

metaM galgluside hs g
is: HMDB00295
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
has only substance units: false
name: galactosyl glucosyl ceramide
is: SBO:0000247
type: Species
boundary condition: false
constant: false
is: C00015
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58223

metaM man6p c
is: CHEBI:17369
is: SBO:0000247
is: HMDB01078
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
has only substance units: false
boundary condition: false
name: D-Mannose 6-phosphate
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0

metaM CE5786 e
name: kinetensin
has only substance units: false
initial amount: NaN
is: HMDB02710
is: CHEBI:27485
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
constant: false

metaR PIPLC
is: SBO:0000176
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.4.11
name: phosphatidylinositol phospholipase C
type: Reaction
reversible: false
product: MODEL1310110008#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_5e0cc3ca_4d56_47bf_a575_5e4ddb99b563
constant: false
is encoded by: hsa:5211
is: SBO:0000297
has only substance units: false
initial concentration: NaN
name: PFKL:PFKP
has part: Q7L2M7
type: Species
boundary condition: true
initial amount: NaN

metaM lnlncacrn m
constant: false
boundary condition: false
is: SBO:0000247
name: alpha-linolenyl carnitine
is: HMDB06319
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
type: Species
initial amount: NaN

metaM pail hs n
name: 1-phosphatidyl-1D-myo-inositol(1-)
type: Species
boundary condition: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
initial amount: NaN
is: SBO:0000247
is: CHEBI:57880
initial concentration: 1.0
has only substance units: false
constant: false

metaM Rtotal2 e
is: SBO:0000247
is: HMDB00244
is: C00255
initial amount: NaN
name: R total 2 position
is: CHEBI:3554
notes: FORMULA: CO2FULLR2 CHARGE: -1
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
has only substance units: false

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

metaM succ x
is: HMDB00254
is: SBO:0000247
type: Species
has only substance units: false
name: Succinate
is: C00042
boundary condition: false
is: CHEBI:30031
constant: false
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
initial amount: NaN

metaR ALCD21 L
modifier: MODEL1310110008#
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.1.99.24
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
reactant: MODEL1310110008#
is: SBO:0000176
product: MODEL1310110008#
name: alcohol dehydrogenase (L-1,2-propanediol)
kinetic law: MODEL1310110008#

metaM xol27oh m
boundary condition: false
constant: false
has only substance units: false
is: HMDB02103
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17703
name: 26-hydroxycholesterol
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
type: Species

metaR RE1796R
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.145
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
type: Reaction
name: RE1796
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110008#

metaR H2Ot
reactant: MODEL1310110008#
reversible: true
name: H2O transport via diffusion
fast: false
kinetic law: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:renamed from H20t5 to H2Ot NCD
is: SBO:0000185
modifier: MODEL1310110008#
is described by: ECO:0000269

metaM 2decdicoa m
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
constant: false
name: 2,7-decadienoylcoa

metaR S23T3g
reversible: false
fast: false
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.6
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_bb0b78e3_7606_443f_9047_48dcd662c076
has only substance units: false
initial amount: NaN
name: LPL
is encoded by: hsa:4023
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is: P06858
constant: false

metaM Asn X Ser Thr r
initial amount: NaN
is: C01342
is: SBO:0000247
is: CHEBI:28938
notes: FORMULA: XH CHARGE: 0
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
has only substance units: false
name: protein-linked asparagine residue (N-glycosylation site)
is: HMDB00051

http://identifiers.org/biomodels.db/MODEL1310110008#_2a512ce0_aadc_4b0f_9f8c_c8a66c24b4fe
is: Q59F77
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: PLCB2
constant: false
initial concentration: NaN
is encoded by: hsa:5330
is: SBO:0000252

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaM ptdcacoa c
constant: false
initial concentration: 1.0
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB06499
has only substance units: false
type: Species
name: pentadecanoyl Coenzyme A

metaR RE3556C
is: SBO:0000176
name: RE3556
kinetic law: MODEL1310110008#
reversible: true
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110008#

metaR RE0915E
is: SBO:0000176
reactant: MODEL1310110008#
name: RE0915
reversible: true
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
fast: false
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.2.1.17
type: Reaction
modifier: MODEL1310110008#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.1

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaM g3m8masn r
initial concentration: 1.0
type: Species
constant: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: C05873
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C88H147N2O70X CHARGE: 0
is: SBO:0000247

metaM 3hmp m
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
name: 3-hydroxy-2-methylpropanoate
is: SBO:0000247
is: HMDB00023
is: CHEBI:11805
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
boundary condition: false
initial amount: NaN

metaR r1706
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110008#
reversible: false
modifier: MODEL1310110008#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110008#
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110008#

metaM xylu D c
name: D-xylulose
constant: false
is: HMDB01644
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m1/s1
initial concentration: 1.0
is: CHEBI:17140
boundary condition: false

metaR TETDEC2CRNe
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of tetradecadienoyl carnitine into extra cellular space
type: Reaction

metaR AG13T15g
product: MODEL1310110008#
modifier: MODEL1310110008#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110008#
type: Reaction
is described by: ECO:0000000

metaR HACD1m
type: Reaction
kinetic law: MODEL1310110008#
is: SBO:0000176
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
reactant: MODEL1310110008#
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110008#_05fa084a_daef_46df_bd1e_92a89391c439
is: SBO:0000252
boundary condition: true
name: BAAT
type: Species
initial concentration: NaN
is: Q14032
is encoded by: hsa:570
initial amount: NaN
constant: false
has only substance units: false

metaR r0801
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
kinetic law: MODEL1310110008#
fast: false
product: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110008#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1

http://identifiers.org/biomodels.db/MODEL1310110008#_ebc30fb2_fe41_4748_a4fc_2f3ff289e362
name: ALDOB
is encoded by: hsa:229
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: P05062
constant: false
boundary condition: true
type: Species

metaR SO4t4 2
reactant: MODEL1310110008#
reversible: true
kinetic law: MODEL1310110008#
is: SBO:0000185
type: Reaction
name: sulfate transport via sodium symport
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
modifier: MODEL1310110008#
is described by: ECO:0000269
fast: false
product: MODEL1310110008#

metaM 2dpmhobq m
is: HMDB06484
boundary condition: false
notes: FORMULA: C58H88O4 CHARGE: 0 INCHI: InChI=1S/C58H88O4/c1-43(2)23-14-24-44(3)25-15-26-45(4)27-16-28-46(5)29-17-30-47(6)31-18-32-48(7)33-19-34-49(8)35-20-36-50(9)37-21-38-51(10)39-22-40-52(11)41-42-54-53(12)55(59)57(61)58(62-13)56(54)60/h23,25,27,29,31,33,35,37,39,41,61H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b44-25+,45-27+,46-29+,47-31+,48-33+,49-35+,50-37+,51-39+,52-41+
initial amount: NaN
is: CHEBI:50771
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: 2-decaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone
type: Species
constant: false

metaR EX tethex3 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosahexaenoic acid, n-3 exchange
type: Reaction

metaM hdd2crn m
is: SBO:0000247
has only substance units: false
is: HMDB06317
initial amount: NaN
name: trans-Hexadec-2-enoyl carnitine
boundary condition: false
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
constant: false
type: Species
initial concentration: 1.0

metaR FAOXC225C204x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)x
type: Reaction

metaR HSD17B42x
fast: false
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110008#
type: Reaction
name: hydroxysteroid (17-beta) dehydrogenase 4
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
product: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000269
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_27dbb520_1f49_4686_89a9_50a27c25cb6e
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1962
initial amount: NaN
is: Q9NY65
boundary condition: true
name: EHHADH
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_8e5b91fd_8b55_477f_bfa0_dce60361cbc3
is encoded by: hsa:4594
has only substance units: false
is: P22033
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: MUT
type: Species
initial concentration: NaN

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaR r0739
reactant: MODEL1310110008#
is described by: ECO:0000000
reversible: true
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:
modifier: MODEL1310110008#
product: MODEL1310110008#

metaM sph1p c
is: HMDB01383
constant: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
initial amount: NaN
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:57939
has only substance units: false

metaR FAOXC225C226m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

metaM retinol c
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00305
type: Species
boundary condition: false
is: CHEBI:50211
name: retinol
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_8081049e_40c8_40eb_b195_9498ce367b74
has only substance units: false
type: Species
is: SBO:0000252
constant: false
name: PDE8A
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5151
boundary condition: true
is: H0YMZ7

metaM bhb e
boundary condition: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
name: (R)-3-hydroxybutyrate
is: CHEBI:10983
initial concentration: 1.0
is: HMDB00011
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247

metaR M8MASNterg
name: m8masn transport from ER to Golgi apparatus
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11007802 NOTES:NCD
product: MODEL1310110008#
reversible: false
reactant: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
type: Reaction

metaM ksi deg39 l
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C48H81N3O36 CHARGE: 0
type: Species
constant: false
boundary condition: false
name: keratan sulfate I, degradation product 39
is: HMDB00143
is: CHEBI:12936
initial amount: NaN

metaM ddsmsterol r
is: HMDB03896
initial concentration: 1.0
initial amount: NaN
name: 7-dehydrodesmosterol
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
constant: false
is: CHEBI:27910
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM ibcoa m
is: CHEBI:57338
initial amount: NaN
boundary condition: false
is: HMDB01243
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
has only substance units: false
constant: false
type: Species
name: isobutyryl-CoA(4-)

metaR ACP1 FMN
fast: false
is: SBO:0000176
reactant: MODEL1310110008#
modifier: MODEL1310110008#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.2
kinetic law: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:8522318 NOTES:INVALID ECO TERM: IFH
name: acid phosphatase (FMN)
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110008#_ea356598_de34_4cbb_aaa4_8de16449012b
type: Species
name: ACPP
boundary condition: true
is encoded by: hsa:55
initial amount: NaN
is: SBO:0000252
is: P15309
has only substance units: false
initial concentration: NaN
constant: false

metaM gtp e
is: HMDB01273
type: Species
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: SBO:0000247
has only substance units: false
constant: false
name: GTP(4-)
initial amount: NaN
boundary condition: false
is: CHEBI:37565
initial concentration: 1.0

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaM hs deg17 l
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
constant: false
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
is: CHEBI:21338
name: heparan sulfate, degradation product 17
initial amount: NaN
is: HMDB02704
initial concentration: 1.0

metaR ASPTA
product: MODEL1310110008#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.1
reversible: true
name: aspartate transaminase

metaM xol27oh r
is: HMDB02103
is: CHEBI:17703
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
boundary condition: false
name: 26-hydroxycholesterol
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaR r1705
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: false
product: MODEL1310110008#
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_347adca0_0995_4598_946d_930ecc43a2e2
name: ALG3
type: Species
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10195

metaR EX dchac LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for deoxycholic acid
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_586bc039_78e7_4f2f_b6d2_d1713471bca5
is: SBO:0000252
is encoded by: hsa:54363
boundary condition: true
is: Q9UJM8
initial amount: NaN
has only substance units: false
name: HAO1
initial concentration: NaN
constant: false
type: Species

metaR NDP8ex
product: MODEL1310110008#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110008#
type: Reaction
name: nucleoside-diphosphatase (UTP), extracellular
reactant: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
fast: false
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.6.1.6

metaR NADtpu
product: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: NAD transporter, peroxisome
reactant: MODEL1310110008#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110008#_5b81fb27_723c_4f1e_bd9a_39aab6004d4c
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2713
type: Species
name: GK3P
initial concentration: NaN
has only substance units: false
constant: false

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR C181CPT2
modifier: MODEL1310110008#
name: transport of Octadecenoyl-CoA into mitochondrial matrix
product: MODEL1310110008#
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV
reactant: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110008#

metaM sph1p e
has only substance units: false
initial amount: NaN
type: Species
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: SBO:0000247
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
initial concentration: 1.0
is: CHEBI:57939
is: HMDB01383
boundary condition: false
constant: false

metaM malttr e
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: C01835
name: maltotriose
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
is: CHEBI:27931
initial amount: NaN
is: HMDB01262
has only substance units: false
type: Species
constant: false

metaR URAt
kinetic law: MODEL1310110008#
is described by: ECO:0000269
type: Reaction
reversible: true
product: MODEL1310110008#
name: uracil transport via facilated diffusion
modifier: MODEL1310110008#
is: SBO:0000185
reactant: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110008#_4b4a8c5b_e295_4117_aba2_7eaeb1e8a9c9
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:55293
has only substance units: false
is: Q8IX04
name: UEVLD

metaM galside hs l
boundary condition: false
initial concentration: 1.0
is: CHEBI:12947
name: D-galactosyl-N-acylsphingosine
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
constant: false
type: Species

metaM Rtotal2 c
is: HMDB01564
has only substance units: false
initial amount: NaN
name: R total 2 position
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: CO2FULLR2 CHARGE: -1
constant: false
type: Species
boundary condition: false
is: CHEBI:57876

http://identifiers.org/biomodels.db/MODEL1310110008#_7c87a77c_1445_4dc9_9b72_fcdf8401fdb1
is: E9KL44
is encoded by: hsa:3030
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
has only substance units: false
name: HADHA
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110008#_e99a0f4b_fe51_4e25_97ca_4607bb08d1ce
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: SOD1
has only substance units: false
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:6647
is: P00441

metaM gtp c
is: HMDB01273
type: Species
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
name: GTP
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:37565
initial amount: NaN
is: C00044

metaR r0734
product: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
reactant: MODEL1310110008#
reversible: false
fast: false
kinetic law: MODEL1310110008#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_7d7758ca_3a51_48aa_8719_c73d5a0ff5f5
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: LHPP
constant: false
is encoded by: hsa:64077
is: Q9H008

metaM cdp m
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP(3-)
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: false
is: HMDB01546
is: CHEBI:58069
initial concentration: 1.0

metaR VALPHELAT2tc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Valine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM hexdicoa r
constant: false
is: C08260
is: SBO:0000247
name: hexadecanedioylcoa
has only substance units: false
boundary condition: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
type: Species
is: HMDB00672
initial amount: NaN
initial concentration: 1.0

metaR RE3050R
reversible: true
name: RE3050
is: SBO:0000176
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110008#_ec98be67_a506_4291_95d3_b3b8e38d6c94
boundary condition: true
is encoded by: hsa:8372
constant: false
is: SBO:0000252
has only substance units: false
is: O43820
initial amount: NaN
type: Species
name: HYAL3
initial concentration: NaN

metaR MG3er
product: MODEL1310110008#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
type: Reaction
reactant: MODEL1310110008#
fast: false
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
kinetic law: MODEL1310110008#
is: SBO:0000176

metaM doco13ac e
is: SBO:0000247
name: docosenoic acid (C22:1)
is: HMDB02068
initial concentration: 1.0
constant: false
notes: FORMULA: C22H41O2 CHARGE: -1
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_88ecadd2_64d0_4e04_95e0_f197dcfc2723
initial amount: NaN
name: PANK3
is: Q9H999
is encoded by: hsa:79646
constant: false
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaR FAOXC2242046m
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: false
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
modifier: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
product: MODEL1310110008#

metaR r0051
modifier: MODEL1310110008#
fast: false
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
is version of: http://identifiers.org/ec-code/3.1.3.5
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110008#
is: SBO:0000176
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110008#_ec2dd789_f59b_4218_9a1f_fbc1d20802ff
type: Species
is: P46926
has only substance units: false
name: GNPDA1
is encoded by: hsa:10007
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM cdp n
constant: false
name: CDP(3-)
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: HMDB01546
is: CHEBI:58069
initial concentration: 1.0
is: SBO:0000247

metaR r0735
kinetic law: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
reversible: true
reactant: MODEL1310110008#
modifier: MODEL1310110008#

metaR RE1796M
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.145
is described by: ECO:0000000
name: RE1796
is: SBO:0000176
reversible: true
product: MODEL1310110008#
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110008#_5a1bc51c_d7d7_439c_ac09_92a541a656b5
has only substance units: false
is: O00400
name: SLC33A1
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:9197
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_0e8a5c2c_c406_4df2_be8d_bb94364cb8ad
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:51181
constant: false
name: DCXR
is: Q7Z4W1
boundary condition: true

metaM Asn X Ser Thr l
is: SBO:0000247
is: HMDB00051
is: C01342
is: CHEBI:28938
constant: false
type: Species
boundary condition: false
initial amount: NaN
name: protein-linked asparagine residue (N-glycosylation site)
has only substance units: false
notes: FORMULA: XH CHARGE: 0
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_7d437f30_db3b_415e_9f92_801fd37d4873
type: Species
has only substance units: false
is: Q86YW0
constant: false
initial concentration: NaN
name: PLCZ1
boundary condition: true
is encoded by: hsa:89869
is: SBO:0000252
initial amount: NaN

metaR r0732
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110008#
product: MODEL1310110008#
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110008#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110008#_2840d130_3f19_49ce_8a70_6148f384f506
name: FDFT1
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P37268
is encoded by: hsa:2222
type: Species
constant: false
initial concentration: NaN

metaM xoltriol c
is: HMDB01457
type: Species
initial concentration: 1.0
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
is: SBO:0000247
is: CHEBI:16496
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN

metaR ME2m
is version of: http://identifiers.org/ec-code/1.1.1.38
reversible: false
modifier: MODEL1310110008#
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: malic enzyme (NADP), mitochondrial
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
is version of: http://identifiers.org/ec-code/1.1.1.40
kinetic law: MODEL1310110008#
product: MODEL1310110008#

metaM tststerone r
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:17347
initial concentration: 1.0
name: testosterone
has only substance units: false
initial amount: NaN
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
constant: false
is: HMDB00234

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_9f5ddabe_c49e_4458_92bb_6bb312674732
has only substance units: false
constant: false
name: SLC16A10
boundary condition: true
initial concentration: NaN
is encoded by: hsa:117247
is: SBO:0000252
type: Species
initial amount: NaN
is: Q8TF71

metaM prostgi2 e
type: Species
name: prostaglandin I2(1-)
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01335
constant: false
is: CHEBI:57403
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
initial amount: NaN

metaM uacgam g
type: Species
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00290
is: CHEBI:57705
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR M13N2Tg
type: Reaction
reactant: MODEL1310110008#
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.1.101
fast: false
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
is: SBO:0000176
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
product: MODEL1310110008#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110008#_ffb02519_2528_49dc_8464_e5fa43c7859b
is encoded by: hsa:29922
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
name: NME7
initial concentration: NaN
has only substance units: false
constant: false
is: Q9Y5B8

metaR FACOAL246 1
kinetic law: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
is: SBO:0000176
is described by: ECO:0000000
reversible: true
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110008#

metaM hdd2crn c
has only substance units: false
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
boundary condition: false
is: HMDB06317
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
name: trans-Hexadec-2-enoyl carnitine
constant: false

metaR r0733
is described by: ECO:0000000
reversible: false
fast: false
modifier: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.12
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_6559f973_faf2_466a_a1b9_95975bc4a62d
initial amount: NaN
is encoded by: hsa:1215
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is: Q4FEB3
boundary condition: true
has only substance units: false
name: CMA1

metaM galside hs c
constant: false
is: SBO:0000247
is: CHEBI:12947
type: Species
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
has only substance units: false
initial amount: NaN
boundary condition: false
name: D-galactosyl-N-acylsphingosine

http://identifiers.org/biomodels.db/MODEL1310110008#_e4b6b19e_2d22_48d8_83a0_dd4f4b075b0c
name: UCKL1
constant: false
initial concentration: NaN
boundary condition: true
is: Q53HM1
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:54963

metaR EX c8crn
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoyl carnitine
type: Reaction

metaR EX dheas LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dehydroepiandrosterone sulfate exchange
type: Reaction

metaM 35cgmp c
has only substance units: false
constant: false
type: Species
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 3',5'-cyclic GMP(1-)
boundary condition: false
is: CHEBI:57746
is: HMDB01314

http://identifiers.org/biomodels.db/MODEL1310110008#_f2feebc4_9bc3_417a_b6ef_f4df8a2d2bb8
initial concentration: NaN
is: B7Z5T8
boundary condition: true
has only substance units: false
is encoded by: hsa:1375
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
name: CPT1B

metaR TCYNTtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
reversible: false
name: Thiocyanate transport via diffusion (mitochondrial)
reactant: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaM c6crn x
notes: FORMULA: C13H25NO4 CHARGE: 0
has only substance units: false
is: HMDB00705
constant: false
type: Species
name: hexanoyl carnitine
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_af234794_8afe_4e62_ac0e_f74e33e7b6c2
is: SBO:0000252
is: B4DER4
initial amount: NaN
name: PIK3CB
has only substance units: false
is encoded by: hsa:5291
type: Species
boundary condition: true
constant: false
initial concentration: NaN

metaR S6T7g
reactant: MODEL1310110008#
modifier: MODEL1310110008#
reversible: false
is: SBO:0000176
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110008#
is described by: ECO:0000000
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction

metaR r0730
type: Reaction
product: MODEL1310110008#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110008#
fast: false
modifier: MODEL1310110008#
reversible: false
kinetic law: MODEL1310110008#
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaR GLCNACASE3ly
kinetic law: MODEL1310110008#
name: alpha-N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.50
product: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
type: Reaction
reactant: MODEL1310110008#
is: SBO:0000176
fast: false
reversible: false

metaM Rtotalcoa c
boundary condition: false
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
initial amount: NaN
name: R total Coenzyme A
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:16189
is: HMDB01448
constant: false
type: Species

metaM em2emgacpail prot hs r
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
initial concentration: 1.0
is: C00213
constant: false
is: SBO:0000247
is: HMDB00271
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2X CHARGE: 0
is: CHEBI:3513

metaR r1421
name: Free diffusion
reactant: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reversible: true
fast: false

metaR C181CPT1
type: Reaction
name: transport of Octadecenoyl-CoA into mitochondrial matrix
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
modifier: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000269
reversible: false
product: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_839d2101_a107_4357_a813_97fdaaebf03c
is: B7Z3I7
has only substance units: false
type: Species
constant: false
boundary condition: true
is encoded by: hsa:4190
name: MDH1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_53dbad36_08ec_4a30_bf2f_1e06ae7ca083
type: Species
is encoded by: hsa:10870
name: HCST
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: Q9UBK5

http://identifiers.org/biomodels.db/MODEL1310110008#_3fa7292e_b852_43f2_ba65_975ba5095558
is: P04746
has only substance units: false
initial concentration: NaN
name: AMY2A
is encoded by: hsa:279
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252

metaR MTHFCm
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.3
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true
is described by: ECO:0000269
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
type: Reaction

metaM dhea r
name: 3beta-hydroxyandrost-5-en-17-one
type: Species
is: SBO:0000247
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:28689
constant: false
has only substance units: false
is: HMDB00077

metaM malcoa r
constant: false
is: CHEBI:57384
is: HMDB01175
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: malonyl-CoA(4-)
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
has only substance units: false
type: Species
is: SBO:0000247

metaM cs e deg1 l
has only substance units: false
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00868
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
constant: false
boundary condition: false
is: CHEBI:57737
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_39979b39_5312_4f8e_b5c7_a4ef52611c29
has only substance units: false
initial amount: NaN
type: Species
name: _AI926493_1_c
boundary condition: true
is encoded by: hsa:AI926493
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_b601b3fc_cec0_4312_9a8e_66ee201c23d6
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: Q10469
is encoded by: hsa:4247
name: MGAT2
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR r0731
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110008#
reversible: false
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110008#

metaR FAOXC163GC142m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_9677a507_75d9_432d_9793_d7a2424d38e7
has only substance units: false
is: P54802
is encoded by: hsa:4669
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: NAGLU
type: Species

metaR EX c81crn
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octenoyl carnitine
type: Reaction

metaR RE0344C
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.65
name: RE0344
is version of: http://identifiers.org/ec-code/3.1.2.2
reversible: true
fast: false
kinetic law: MODEL1310110008#
product: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_060d0424_a463_401b_9d72_666b324c4bf1
name: CTSA
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is: P10619
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:5476

metaM g1p c
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
is: CHEBI:58601
name: D-Glucose 1-phosphate
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: C00103
is: HMDB01586
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_d373b599_eca8_4cd8_aec4_61a2d491febf
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3030
boundary condition: true
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:3032
has part: P55084
has part: E9KL44
name: HADHA:HADHB
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_fe2ce6a2_8ba9_46b5_ac36_6878ca8220fa
constant: false
is: SBO:0000297
is encoded by: hsa:8503
has only substance units: false
name: PIK3CD:PIK3R3
initial concentration: NaN
initial amount: NaN
boundary condition: true
has part: A7E2E0
has part: Q92569
is encoded by: hsa:5293
type: Species

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_a1260432_0d0f_4cd0_b65d_186e8f05b603
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:6576
name: SLC25A1
constant: false
is: SBO:0000252
is: D9HTE9
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_a6085106_9b36_45f7_a9b9_c8c9e872f015
is encoded by: hsa:1719
name: DHFR
is: P00374
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_1dabf817_cc8b_4c06_8d37_20ee9f01b888
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: P04745
type: Species
is encoded by: hsa:278
name: AMY1C

http://identifiers.org/biomodels.db/MODEL1310110008#_156dd3af_6e48_4ea4_b915_482893fc62c2
is encoded by: hsa:AI697028
type: Species
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: _AI697028_1_m

metaR XOL27OHtm
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110008#
name: 27 hydroxy cholesterol transport
fast: false
reversible: true
product: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ

metaR AKR1C1
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (1645.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.1.20 Confidence Level: 4 AUTHORS: PMID:8486699 NOTES:NJ
type: Reaction
name: aldo-keto reductase family 1, member C1 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.3.1.20
reversible: false
modifier: MODEL1310110008#
is described by: ECO:0000269
reactant: MODEL1310110008#
is: SBO:0000176
fast: false

metaM acgam r
is: HMDB00215
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
name: N-acetyl-D-glucosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: SBO:0000247
is: CHEBI:17411
initial concentration: 1.0
type: Species

metaM gtp m
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
name: GTP
has only substance units: false
boundary condition: false
is: HMDB01273
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: C00044
type: Species
is: CHEBI:37565

metaM gtp n
initial concentration: 1.0
is: CHEBI:37565
constant: false
boundary condition: false
is: HMDB01273
has only substance units: false
is: SBO:0000247
name: GTP(4-)
initial amount: NaN
type: Species
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044

http://identifiers.org/biomodels.db/MODEL1310110008#_f86d9d3c_f17e_4031_9725_0e6c312a5f58
is encoded by: hsa:10654
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: PMVK
type: Species
is: Q6FGV9
is: SBO:0000252
boundary condition: true

metaM bhb m
is: HMDB00011
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
type: Species
initial amount: NaN
is: CHEBI:10983
initial concentration: 1.0
name: (R)-3-hydroxybutyrate

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaM gar c
type: Species
is: HMDB02022
is: SBO:0000247
name: N1-(5-Phospho-D-ribosyl)glycinamide
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
is: CHEBI:58457
has only substance units: false
initial amount: NaN
is: C03838

http://identifiers.org/biomodels.db/MODEL1310110008#_d4943217_8ddc_413c_9239_f203ab8955a5
has only substance units: false
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:AI971036
name: _AI971036_1_c
initial amount: NaN
is: SBO:0000252

metaR S6TASE8ly
reversible: true
reactant: MODEL1310110008#
name: N-acetylgalactosamine-6-sulfatase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110008#
is described by: ECO:0000000
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false

metaR 5OXPROt
kinetic law: MODEL1310110008#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110008#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 5-oxoprolinate
fast: false
reversible: true
product: MODEL1310110008#

metaR G14T7g
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
modifier: MODEL1310110008#
product: MODEL1310110008#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110008#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
is: SBO:0000176

metaR BILGLCURtr
type: Reaction
reactant: MODEL1310110008#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
fast: false
kinetic law: MODEL1310110008#
name: glucuronidated compound transport
reversible: true
is described by: ECO:0000000
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_7fac180a_40b0_438d_acbc_964b6b096d33
constant: false
name: ALDH7A1
is: SBO:0000252
is: E7EPT3
is encoded by: hsa:501
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species

metaM galside hs g
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:12947
has only substance units: false
name: D-galactosyl-N-acylsphingosine
boundary condition: false

metaR XYLUR
reversible: true
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
product: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.10
is described by: ECO:0000269
fast: false
is: SBO:0000176
type: Reaction
name: xylulose reductase

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaM thcrm hs g
boundary condition: false
name: trihexosyl ceramide
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
has only substance units: false
is: CHEBI:24636
constant: false
is: SBO:0000247

metaR OCTAt
fast: false
reactant: MODEL1310110008#
product: MODEL1310110008#
kinetic law: MODEL1310110008#
name: Octanoate transport via diffusion
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_78ec0036_9fce_4aa4_857d_e49e4f5b3aac
type: Species
name: NOS1
constant: false
boundary condition: true
is: B4DG68
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4842
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_fa355029_2643_4adc_a546_b5059641617f
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: Q9BY49
initial concentration: NaN
name: PECR
is encoded by: hsa:55825

metaR r0321
fast: false
reactant: MODEL1310110008#
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
is version of: http://identifiers.org/ec-code/6.3.5.2
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000000
reversible: false
type: Reaction
is: SBO:0000176
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_02e0cc90_35c3_4546_a4fa_6e9fb4419a10
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:761
type: Species
is: P07451
name: CA3
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM prostgi2 c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
name: prostaglandin I2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: HMDB01335
has only substance units: false
is: CHEBI:57403
type: Species

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

W3 CDTF: Fri Aug 31 03:07:06 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110008#_89f5bbe4_aa19_4b4b_9295_6793ab906eb4
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is: Q76EJ3
name: SLC35D2
has only substance units: false
type: Species
is encoded by: hsa:11046
initial concentration: NaN

metaR AMPtp
fast: false
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: AMP transporter, peroxisome
reversible: true
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ

http://identifiers.org/biomodels.db/MODEL1310110008#_3cf85889_525d_4046_a063_2c64dfdd74e6
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1374
initial amount: NaN
is: Q8WZ48
name: CPT1A
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_b692b6c1_1a72_460e_8340_ac8e0d68e751
is encoded by: hsa:81539
initial concentration: NaN
type: Species
name: SLC38A1
is: Q9H2H9
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR STRDNCCPT2
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110008#
reversible: false
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000000
type: Reaction
name: carnitine transferase

metaR P5CDm
is version of: http://identifiers.org/ec-code/1.5.1.12
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
kinetic law: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
reversible: false
is: SBO:0000176
product: MODEL1310110008#
type: Reaction
is described by: ECO:0000269
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
modifier: MODEL1310110008#

metaM hs deg21 l
is: CHEBI:16126
constant: false
initial concentration: 1.0
notes: FORMULA: C37H55NO38S2 CHARGE: -4
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: SBO:0000247

metaM 2decdicoa x
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
initial concentration: 1.0
type: Species
name: 2,7-decadienoylcoa
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110008#_56f32f9b_b58a_4fd3_b75d_dfc1541aa0b2
is: P31040
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:6389
is: SBO:0000252
boundary condition: true
name: SDHA
has only substance units: false
initial amount: NaN

metaR CSNAT2m
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.7
product: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
fast: false
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
modifier: MODEL1310110008#
reversible: true
name: carnitine O-aceyltransferase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110008#_ee101e1a_dc86_4508_bfca_e0eb38586f4b
boundary condition: true
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6487
name: ST3GAL3
has only substance units: false

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_fcb72702_db5d_4095_9729_724d916a5e75
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI926493
name: _AI926493_1_m
has only substance units: false
type: Species

W3 CDTF: Fri Aug 31 03:07:06 BST 2012

metaR EX tststerones LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: testosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_0fe95410_6b83_4a78_99d3_137404fec103
type: Species
initial concentration: NaN
is: P19440
is encoded by: hsa:2678
has only substance units: false
constant: false
name: GGT1
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_d3dfbcce_8dd7_42a8_aa0d_9b153fc09fa2
name: NDUFA12
constant: false
is: F8VQS7
is encoded by: hsa:55967
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR ALCD21 D
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
is: SBO:0000176
type: Reaction
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.1
reversible: false
reactant: MODEL1310110008#
name: alcohol dehydrogenase (D-1,2-propanediol)
is version of: http://identifiers.org/ec-code/1.1.99.24
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110008#

metaR STRDNCCPT1
is: SBO:0000176
reversible: false
reactant: MODEL1310110008#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
product: MODEL1310110008#
name: carnitine O-palmitoyltransferase

metaM galside hs e
type: Species
is: CHEBI:12947
name: D-galactosyl-N-acylsphingosine
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
constant: false
has only substance units: false
initial concentration: 1.0

metaR ALAt2r
name: L-alanine reversible transport via proton symport
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: true
is described by: ECO:0000304
modifier: MODEL1310110008#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
fast: false
reactant: MODEL1310110008#

metaR RE1836X
reactant: MODEL1310110008#
is: SBO:0000176
product: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
modifier: MODEL1310110008#
reversible: true
is described by: ECO:0000000
name: RE1836
type: Reaction
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.176

http://identifiers.org/biomodels.db/MODEL1310110008#_8d2d0441_751f_436c_872b_89d7a08478ee
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:M68895
boundary condition: true
constant: false
name: _M68895_1_c
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_d37ce53a_c2f8_4904_a04b_198af22348a3
has only substance units: false
name: ATP5E
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is: P56381
is encoded by: hsa:514

metaR r1428
is: SBO:0000185
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
reactant: MODEL1310110008#
name: Free diffusion
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110008#
fast: false
type: Reaction

metaR ASNS1
reversible: false
notes: GENE_ASSOCIATION: (440.1) or (440.3) or (440.2) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 6.3.5.4 Confidence Level: 4 AUTHORS: PMID:2564390,PMID:2886907 NOTES:
is: SBO:0000176
product: MODEL1310110008#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110008#
reactant: MODEL1310110008#
name: asparagine synthase (glutamine-hydrolysing)
fast: false
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/6.3.5.4

metaM dcacoa x
is: HMDB06404
has only substance units: false
is: C05274
is: SBO:0000247
name: Decanoyl-CoA (n-C10:0CoA)
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: CHEBI:61430
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274

http://identifiers.org/biomodels.db/MODEL1310110008#_795514e5_41b1_40c2_a2e0_477dbda1fc7f
name: NME1
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:4830

metaM glyclt x
name: glycolate
boundary condition: false
constant: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
initial amount: NaN
is: HMDB00115
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:29805
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_84cdf259_3787_4578_a7b9_332d6180bb9f
is: SBO:0000252
is: O75355
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:956
has only substance units: false
type: Species
name: ENTPD3

metaM l2n2m2mn l
has only substance units: false
is: HMDB00143
constant: false
initial amount: NaN
notes: FORMULA: C54H91N3O41 CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
type: Species
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110008#_4b4ddb19_a980_4036_af15_2a6546686278
initial concentration: NaN
name: SDHC
is: Q99643
is encoded by: hsa:6391
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species

metaR RE0569E
reactant: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000176
modifier: MODEL1310110008#
name: RE0569
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (4017.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
type: Reaction
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_6114b85a_a67d_4508_bde7_dbeff56658c8
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: ATP2B4
is: P23634
is encoded by: hsa:493
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_18f0cd6d_e41a_4e91_bf16_85c95fc910da
is encoded by: hsa:2585
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q01415
name: GALK2

metaM 4ppan c
name: D-4'-Phosphopantothenate
type: Species
is: HMDB01016
initial concentration: 1.0
is: C03492
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
is: SBO:0000247
constant: false
is: CHEBI:10986

metaR DMATTx
fast: false
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000176
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.5.1.1
type: Reaction
is described by: ECO:0000134
name: dimethylallyltranstransferase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110008#_14388d22_d559_4363_9cd3_7ac73d7e0064
boundary condition: true
is encoded by: hsa:3036
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: HAS1
is: SBO:0000252
is: Q8IYH3
initial amount: NaN

metaR CYSO
modifier: MODEL1310110008#
is: SBO:0000176
kinetic law: MODEL1310110008#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
is version of: http://identifiers.org/ec-code/1.13.11.20
product: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
name: cysteine oxidase
reversible: false

metaM aprgstrn e
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042
type: Species
constant: false
is: HMDB03069
boundary condition: false
initial amount: NaN
name: (20S)-20-hydroxypregn-4-en-3-one
is: SBO:0000247
is: CHEBI:28453

metaM ach c
initial concentration: 1.0
type: Species
has only substance units: false
name: acetylcholine
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: HMDB00895
is: CHEBI:15355
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false

metaM mn l
initial concentration: 1.0
has only substance units: false
type: Species
name: beta-1,4-mannose-N-acetylglucosamine
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
initial amount: NaN
constant: false
boundary condition: false
is: HMDB06535
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_ca356e5d_da85_476a_9033_10a133249d40
is: P47989
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
name: XDH
is encoded by: hsa:7498
initial amount: NaN
boundary condition: true

metaR CSPG Btly
name: chondroitin sulfate B transport, extracellular to lysosome
is described by: ECO:0000000
reactant: MODEL1310110008#
is: SBO:0000185
fast: false
product: MODEL1310110008#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110008#

metaR NDPK10n
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
modifier: MODEL1310110008#
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110008#
is: SBO:0000176

metaR FACOAL200
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
type: Reaction
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110008#_23c251ba_9b71_43b6_9e9e_d388836092a4
boundary condition: true
is: SBO:0000252
name: SULT2B1
constant: false
has only substance units: false
is encoded by: hsa:6820
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_32a20f0a_5a0a_4820_8031_f96970c4beba
is: SBO:0000252
name: DGKG
type: Species
constant: false
is: P49619
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:1608

http://identifiers.org/biomodels.db/MODEL1310110008#_b795ff3d_1d34_4470_90f1_7dbfcc3326b9
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is: P49753
is encoded by: hsa:10965
initial amount: NaN
name: ACOT2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_eb3c0fa7_54f8_416a_a59f_c7afdad99b5d
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:11332
is: O00154
name: ACOT7
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false

metaR GAL3ST11
name: Galactosylceramide sulfotransferase
reversible: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110008#
is: SBO:0000176
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.8.2.11
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
product: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false

metaM docoscoa x
initial concentration: 1.0
name: docosanoylcoa
has only substance units: false
initial amount: NaN
type: Species
is: HMDB12930
boundary condition: false
notes: FORMULA: C43H74N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_68d0767b_1b8d_4e8a_ae03_513159741e42
constant: false
boundary condition: true
type: Species
name: ADSL
has only substance units: false
is: SBO:0000252
is encoded by: hsa:158
initial concentration: NaN
initial amount: NaN
is: P30566

metaR GLYCtm
is: SBO:0000185
reactant: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
product: MODEL1310110008#
name: glycerol transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
reversible: true
is described by: ECO:0000000

metaM pdx5p c
has only substance units: false
boundary condition: false
is: CHEBI:58589
constant: false
notes: FORMULA: C8H10NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00459 EHMN_ABBREVIATION: C00627
initial amount: NaN
is: HMDB01319
initial concentration: 1.0
type: Species
is: C00627
is: SBO:0000247
name: Pyridoxine 5'-phosphate

metaR PItg
name: phosphate transport, Golgi apparatus
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110008#
is: SBO:0000185
reactant: MODEL1310110008#
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_03d70398_6541_452e_bc3d_02474fdde3e7
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:3177
constant: false
name: SLC29A2
is: Q14542
boundary condition: true

metaM pyam5p c
is: SBO:0000247
is: HMDB01555
has only substance units: false
notes: FORMULA: C8H12N2O5P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00475 EHMN_ABBREVIATION: C00647
name: Pyridoxamine 5'-phosphate
initial amount: NaN
constant: false
is: C00647
initial concentration: 1.0
is: CHEBI:58451
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_460bfcd1_7994_4610_901a_ff3cd349abc9
has only substance units: false
initial concentration: NaN
name: ADCY7
is: SBO:0000252
type: Species
is encoded by: hsa:113
is: P51828
boundary condition: true
initial amount: NaN
constant: false

metaR FAOXC16DCr
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

metaM ump r
boundary condition: false
name: UMP
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247
initial concentration: 1.0
is: HMDB00288
type: Species
initial amount: NaN
is: CHEBI:57865
has only substance units: false
constant: false

metaM pchol hs c
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
is: CHEBI:16110
has only substance units: false
initial amount: NaN
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
name: Phosphatidylcholine
boundary condition: false

metaR FAOXC226
reversible: false
product: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000000
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
is: SBO:0000176
reactant: MODEL1310110008#
type: Reaction

metaR INSt
type: Reaction
reversible: true
modifier: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
name: Inosine transport (diffusion)
product: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
is: SBO:0000185
is described by: ECO:0000269

metaR GAL3ST12
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.8.2.11
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
name: Galactosylceramide sulfotransferase
product: MODEL1310110008#
reversible: false

metaM aprgstrn c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042
is: SBO:0000247
is: CHEBI:28453
type: Species
boundary condition: false
constant: false
is: HMDB03069
initial amount: NaN
name: (20S)-20-hydroxypregn-4-en-3-one

metaR r0512
fast: false
type: Reaction
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110008#
is: SBO:0000176
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110008#_1bd818b4_73ae_4b2d_8622_00bd9d1ac20d
constant: false
is: SBO:0000252
initial amount: NaN
is: P39656
is encoded by: hsa:1650
name: DDOST
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR r1429
name: Free diffusion
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
reactant: MODEL1310110008#

metaM ksi deg7 l
name: keratan sulfate I, degradation product 7
boundary condition: false
constant: false
initial amount: NaN
is: HMDB01354
has only substance units: false
is: CHEBI:57455
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C210H337N15O181S10 CHARGE: -10

metaM strdnccoa c
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: C16163
is: HMDB06519
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205473
name: stearidonyl coenzyme A
is: SBO:0000247
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1

metaM c226crn c
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
initial concentration: 1.0
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/127055
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB06510
name: cervonyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110008#_081e13d3_8f79_4fda_a095_78f466d6c3fd
constant: false
type: Species
is encoded by: hsa:64077
is: SBO:0000252
name: LHPP
initial amount: NaN
initial concentration: NaN
is: Q9H008
has only substance units: false
boundary condition: true

metaM ksi deg17 l
name: keratan sulfate I, degradation product 17
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00143
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:12936

metaM fuc1p L c
is: HMDB01265
is: SBO:0000247
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
boundary condition: false
constant: false
name: L-Fucose 1-phosphate
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:28319

metaM ttdcrn c
type: Species
has only substance units: false
initial amount: NaN
is: HMDB05066
boundary condition: false
name: tetradecanoyl carnitine
is: http://identifiers.org/pubchem.compound/3413344
is: SBO:0000247
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_659dce5d_bac1_41ba_9fed_68dd0cf32268
constant: false
has only substance units: false
name: ZADH2
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
is: Q4G1C4
is encoded by: hsa:284273

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_0862cbaf_ec41_4233_888b_136f8ed4a6ac
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:55343
initial amount: NaN
is: SBO:0000252
is: B3KQH0
name: SLC35C1
constant: false

metaR EX nrvnc LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nervonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_b73c5c3d_dc33_4130_87c0_650d29d06402
type: Species
is encoded by: hsa:51227
has part: O94777
is encoded by: hsa:9091
has only substance units: false
is: SBO:0000297
has part: Q9BRB3
is encoded by: hsa:5283
is encoded by: hsa:5279
has part: Q14442
has part: Q92535
boundary condition: true
has part: B3KUV7
is encoded by: hsa:5277
initial concentration: NaN
initial amount: NaN
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
constant: false
is encoded by: hsa:8818

metaR DHFR
product: MODEL1310110008#
is: SBO:0000176
reversible: true
modifier: MODEL1310110008#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.3
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
name: dihydrofolate reductase
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
is described by: ECO:0000254

metaR ASNtN1
is: SBO:0000185
name: Asparagine transport (Na, H coupled)
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: true
modifier: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269
type: Reaction
product: MODEL1310110008#

metaM occoa m
type: Species
initial amount: NaN
boundary condition: false
name: Octanoyl-CoA (n-C8:0CoA)
has only substance units: false
is: SBO:0000247
is: C01944
is: CHEBI:57386
initial concentration: 1.0
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: HMDB01070
constant: false

metaR GALASE11ly
modifier: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
reactant: MODEL1310110008#
name: beta-galactosidase, lysosomal
product: MODEL1310110008#
is described by: ECO:0000000
fast: false
is: SBO:0000176

metaR ADK1m
name: adenylate kinase, mitochondrial
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110008#
is: SBO:0000176
reversible: true
fast: false
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_d73e03ad_7ab9_44de_a43a_eaf1b421ab3e
name: CHAT
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1103
is: SBO:0000252
constant: false
is: Q6LEN5

http://identifiers.org/biomodels.db/MODEL1310110008#_14ffaaea_1ee2_434f_a1ab_85bcc42d3355
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: AQP8
is encoded by: hsa:343
is: O94778
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_e13749bc_b0f8_4d73_b5d8_56d18b3c3450
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: _AI285872_1_c
has only substance units: false
constant: false
is encoded by: hsa:AI285872
type: Species

metaR FACOAL203
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110008#
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is: SBO:0000176

metaM thexddcoa m
initial amount: NaN
name: trans7,10-hexadecadienoylcoa
boundary condition: false
is: SBO:0000247
is: HMDB02288
constant: false
notes: FORMULA: C37H58N7O17P3S CHARGE: -4
has only substance units: false
type: Species
initial concentration: 1.0

metaR TRDR
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110008#
type: Reaction
reversible: false
name: thioredoxin reductase (NADPH)
fast: false
reactant: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.8.1.9
product: MODEL1310110008#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110008#_dc41bb7a_4fbf_428f_9c97_38fff3e5970f
has only substance units: false
is: Q9BT22
name: ALG1
initial concentration: NaN
is encoded by: hsa:56052
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252

metaR H2MTer L
modifier: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#
kinetic law: MODEL1310110008#
name: H2 mannosyltransferase, endoplasmic reticulum
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110008#
reversible: false

metaR FAOXC121x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_2ad61124_fe42_414d_9b46_a0079441d306
initial concentration: NaN
is: SBO:0000252
name: ACHE
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:43
type: Species

metaR 13DAMPPOX
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.21
modifier: MODEL1310110008#
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.22
fast: false
product: MODEL1310110008#
is described by: ECO:0000212
kinetic law: MODEL1310110008#
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB

metaM dhea c
boundary condition: false
initial amount: NaN
name: 3beta-hydroxyandrost-5-en-17-one
is: CHEBI:28689
initial concentration: 1.0
is: HMDB00077
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
is: SBO:0000247
constant: false
has only substance units: false
type: Species

metaR FACOAL204
type: Reaction
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
modifier: MODEL1310110008#
is described by: ECO:0000269
fast: false
is: SBO:0000176
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110008#_ae66af04_66db_47cb_9a1e_06d9638eec47
initial concentration: NaN
has only substance units: false
name: PPOX
type: Species
is encoded by: hsa:5498
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is: P50336

metaR Asn X Ser Thrtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
is: SBO:0000185
name: Asn-X-Ser/Thr transport (from ER to lysosome)
reactant: MODEL1310110008#
product: MODEL1310110008#
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110008#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110008#_da186c7f_90a1_4116_8576_753be6363bb6
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:29880
boundary condition: true
name: ALG5
is: Q9Y673

metaM succ m
has only substance units: false
is: C00042
initial amount: NaN
boundary condition: false
is: CHEBI:30031
name: Succinate
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
is: HMDB00254

metaM ptdcacoa m
type: Species
has only substance units: false
constant: false
is: HMDB06499
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
initial concentration: 1.0
is: SBO:0000247
name: pentadecanoyl Coenzyme A
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_2034ce9a_cf0b_4646_bccc_a40a06203162
boundary condition: true
constant: false
is encoded by: hsa:1371
name: CPOX
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is: P36551
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_96c60459_b09f_46f5_8f9c_4815e4250f1f
is: Q16878
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:1036
is: SBO:0000252
name: CDO1
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_7bf74440_59ad_4559_9207_71af4d1373be
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3948
is: P07864
initial concentration: NaN
name: LDHC
type: Species
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_d8a22fd3_a2b5_4852_b7cd_f970d495ad4e
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is: Q8TE04
constant: false
is encoded by: hsa:53354
initial concentration: NaN
name: PANK1
initial amount: NaN

metaM acgam l
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: N-acetyl-D-glucosamine
is: CHEBI:17411
type: Species
boundary condition: false
is: HMDB00215
is: SBO:0000247
constant: false

metaM fprica c
is: SBO:0000247
is: CHEBI:58467
is: C04734
boundary condition: false
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB01439
has only substance units: false
type: Species

metaR FACOAL205
modifier: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000000
type: Reaction
name: fatty-acid--CoA ligase
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110008#_17789246_c87d_4fef_8bd7_98c2476d5e90
initial amount: NaN
constant: false
is encoded by: hsa:3939
name: LDHA
is: P00338
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_0828d072_c6f0_4514_ba3c_c05f85f0a807
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:131
name: ADH7
is: SBO:0000252
is: P40394
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_657cd42b_cf2c_41c6_91d6_3b05575c871c
boundary condition: true
is encoded by: hsa:2495
is: P02794
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
name: FTH1

metaR FAOXC160
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
reactant: MODEL1310110008#
is: SBO:0000176
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: false
name: Beta oxidation of long chain fatty acid
product: MODEL1310110008#

metaR C101CPT1
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decenoylcarnitine
type: Reaction

metaM hexdicoa c
is: HMDB02014
constant: false
boundary condition: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
initial concentration: 1.0
initial amount: NaN
name: hexadecanedioylcoa
has only substance units: false
is: SBO:0000247
type: Species

metaM dhf m
initial concentration: 1.0
boundary condition: false
is: HMDB01056
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: dihydrofolate(2-)
constant: false
type: Species
is: CHEBI:57451

http://identifiers.org/biomodels.db/MODEL1310110008#_4fadc65d_8003_4542_bc37_982dc2aa42b2
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:37
initial amount: NaN
type: Species
constant: false
has only substance units: false
name: ACADVL
is: P49748
boundary condition: true

metaM 42A3HP24DB c
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/7956
initial concentration: 1.0
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
is: C05645
constant: false
is: HMDB04083
boundary condition: false
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
initial amount: NaN
has only substance units: false

metaR AKGMALtm
name: alpha-ketoglutarate/malate transporter
modifier: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
reversible: true
is: SBO:0000185
product: MODEL1310110008#

metaM acgam6p c
is: HMDB01062
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: N-acetyl-D-glucosamine 6-phosphate(2-)
type: Species
is: CHEBI:57513
is: SBO:0000247

metaM gacpail hs r
boundary condition: false
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: HMDB01401
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:61548
type: Species
is: SBO:0000247
has only substance units: false
name: glucosaminyl-acylphosphatidylinositol
is: C00092

metaR O2tm
kinetic law: MODEL1310110008#
name: O2 transport (diffusion)
product: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
type: Reaction
fast: false
reactant: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000000

metaM nrvnc c
is: CHEBI:32392
initial concentration: 1.0
name: nervonate
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: HMDB02368
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
is: SBO:0000247

metaR FAOXC225C204m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaR RE1518M
is: SBO:0000176
fast: false
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.3.99.13
reversible: true
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000
reactant: MODEL1310110008#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
name: RE1518

metaR GNMT
modifier: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.1.20
type: Reaction
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
name: glycine N-methyltransferase
notes: GENE_ASSOCIATION: (27232.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.1.20 Confidence Level: 4 AUTHORS: PMID:10843803,PMID:11810299 NOTES:
fast: false
reversible: false

metaR PFK
reactant: MODEL1310110008#
modifier: MODEL1310110008#
reversible: false
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.1.11
kinetic law: MODEL1310110008#
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5214.1) or (5211.2) or (5214.1 and 5211.1) or (5214.1 and 5213.1) or (5213.1) or (5214.1 and 5211.2) or (5211.1) or (5211.1 and 5213.1) or (5213.1 and 5211.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000304
name: phosphofructokinase

http://identifiers.org/biomodels.db/MODEL1310110008#_959f55b0_8fb4_41f4_a070_a5b4088790d4
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3421
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: E9PDD5
name: IDH3G

http://identifiers.org/biomodels.db/MODEL1310110008#_d2e18ae3_760d_44ef_922c_39b01183afc3
has only substance units: false
is encoded by: hsa:8528
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
name: DDO
type: Species

metaR O2tn
reactant: MODEL1310110008#
is: SBO:0000185
name: O2 nuclear transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
is described by: ECO:0000000

metaR FACOAL245 1
is: SBO:0000176
kinetic law: MODEL1310110008#
reversible: true
product: MODEL1310110008#
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110008#
type: Reaction
name: fatty-acid--CoA ligase
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaM HC02203 c
is: CHEBI:27820
type: Species
is: SBO:0000247
name: prostaglandin-a2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaM cs a l
is: SBO:0000247
constant: false
has only substance units: false
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
is: CHEBI:36005
initial concentration: 1.0
is: HMDB02183
boundary condition: false
type: Species
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_839cad12_3e30_40be_8771_e0a09179f2dc
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10400
name: PEMT
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN

metaR RE3326M
type: Reaction
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
reactant: MODEL1310110008#
modifier: MODEL1310110008#
fast: false
product: MODEL1310110008#
is described by: ECO:0000000
kinetic law: MODEL1310110008#
name: RE3326
is version of: http://identifiers.org/ec-code/1.2.4.4

http://identifiers.org/biomodels.db/MODEL1310110008#_3dec72be_2023_46c7_b1d9_a496246edf26
name: IDI2
is encoded by: hsa:91734
constant: false
initial concentration: NaN
is: Q9BXS1
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR H2O2t
product: MODEL1310110008#
is: SBO:0000185
reactant: MODEL1310110008#
name: hydrogen peroxide transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
type: Reaction
reversible: true
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110008#_44ced8c0_9365_43fb_91e0_165ee4524f77
has only substance units: false
is encoded by: hsa:5832
is: SBO:0000252
constant: false
is: P54886
boundary condition: true
type: Species
initial amount: NaN
name: ALDH18A1
initial concentration: NaN

metaR GLCNACASE4ly
is version of: http://identifiers.org/ec-code/3.2.1.50
type: Reaction
name: alpha-N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110008#
is: SBO:0000176
fast: false
reversible: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
modifier: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#

metaM L2aadp6sa c
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB01263
initial amount: NaN
is: SBO:0000247
is: CHEBI:17917
name: L-allysine
boundary condition: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
type: Species

metaR FORtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
product: MODEL1310110008#
is described by: ECO:0000000
reversible: true
name: FOR transporter, endoplasmic reticulum
reactant: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
is: SBO:0000185

metaR FACOAL245 2
fast: false
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110008#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
name: fatty-acid--CoA ligase

metaM nrvnc e
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
name: nervonate
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB02368
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:32392

http://identifiers.org/biomodels.db/MODEL1310110008#_5ae9e121_c340_4d35_8588_ac400fd0e34b
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: GCK
constant: false
type: Species
is encoded by: hsa:2645
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_3f2d261d_84b3_41aa_a87f_3fc11d2eb8a3
name: CYP1A1
is: A0N0X8
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:1543
type: Species

metaM occoa x
boundary condition: false
initial concentration: 1.0
is: C01944
name: Octanoyl-CoA (n-C8:0CoA)
is: CHEBI:57386
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
has only substance units: false
is: HMDB01070
constant: false
type: Species
is: SBO:0000247
initial amount: NaN

metaR ABTD
type: Reaction
fast: false
name: L-arabinitol 4-dehydrogenase
reactant: MODEL1310110008#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110008#_ecd89818_9aa7_4c8c_8dc6_f81f09d5199d
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:125
type: Species
boundary condition: true
is: P00325
initial concentration: NaN
name: ADH1B

metaM glutcoa c
constant: false
is: HMDB01339
name: glutaryl-CoA(5-)
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1
type: Species

metaR O2tp
reactant: MODEL1310110008#
is: SBO:0000185
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
type: Reaction
name: O2 transport, peroxisomal
product: MODEL1310110008#
is described by: ECO:0000000
fast: false

metaR C100CPT1
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decanoylcarnitine
type: Reaction

metaR SGPL12r
modifier: MODEL1310110008#
is: SBO:0000176
product: MODEL1310110008#
kinetic law: MODEL1310110008#
name: Sphingosine-1-phosphate lyase
reactant: MODEL1310110008#
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.2.27
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
is described by: ECO:0000304
fast: false
reversible: false

metaM tettet6coa c
initial amount: NaN
name: tetracosatetraenoyl coenzyme A
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB06516
has only substance units: false
constant: false
is: C16171
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205481

metaR GGH 7THFe
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
name: Gamma-glutamyl hydrolase (7THF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
modifier: MODEL1310110008#

metaR EX 3ddcrn
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

metaR S6T14g
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
reversible: false
product: MODEL1310110008#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110008#_900fe68a_58d0_46ca_8204_02f501da588a
name: PLCB1
type: Species
has only substance units: false
constant: false
is encoded by: hsa:23236
is: Q9NQ66
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR CYTK9n
is described by: ECO:0000269
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reversible: true
name: cytidylate kinase (CMP,dCTP),nuclear
fast: false
modifier: MODEL1310110008#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110008#_45d5d42d_7157_4997_80c7_8e07d8d6d082
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
name: AMY2B
initial amount: NaN
initial concentration: NaN
constant: false
is: P19961
is encoded by: hsa:280

metaM itacon m
has only substance units: false
initial concentration: 1.0
is: CHEBI:17240
initial amount: NaN
constant: false
is: HMDB02092
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
name: itaconate(2-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_461ba041_ef9e_47f3_9220_6f8175c63e81
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is: Q9GZX3
type: Species
is encoded by: hsa:4166
name: CHST6

metaR DGNSKm
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
name: deoxyguanosine kinase
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.113
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (1716.5) or (1716.1) or (1716.4) or (1716.2) or (1716.3) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:8692979 NOTES:
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_1a4b61d2_e490_4f8e_867f_d004ea52fa23
is: F6SH78
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:60481
boundary condition: true
is: SBO:0000252
has only substance units: false
name: ELOVL5
initial concentration: NaN

metaR FAOXC225C226x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

metaM e4p c
is: SBO:0000247
is: HMDB01321
has only substance units: false
is: C00279
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
is: CHEBI:16897
name: D-Erythrose 4-phosphate
type: Species
initial amount: NaN

metaM tststerone e
type: Species
is: CHEBI:17347
name: testosterone
initial amount: NaN
is: HMDB00234
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_93c946e4_df19_4a2c_97e0_5dbf76b8e3cb
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
name: AK7
is: Q96M32
initial amount: NaN
type: Species
is encoded by: hsa:122481
is: SBO:0000252

metaM dhf c
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
boundary condition: false
is: C00415
is: CHEBI:57451
name: 7,8-Dihydrofolate
has only substance units: false
is: HMDB01056

metaM adp r
is: CHEBI:456216
boundary condition: false
has only substance units: false
is: SBO:0000247
name: ADP(3-)
is: HMDB01341
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false

metaR OMPDC
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.10
is: SBO:0000176
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
product: MODEL1310110008#
modifier: MODEL1310110008#
fast: false
name: orotidine-5'-phosphate decarboxylase
reversible: false
is described by: ECO:0000269

metaM n2m2masn g
is: SBO:0000247
is: C11530
has only substance units: false
notes: FORMULA: C50H83N4O35X CHARGE: 0
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
type: Species
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaR NADtx
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
fast: false
type: Reaction
name: transport of NAD into peroxisome
reactant: MODEL1310110008#
is described by: ECO:0000134
kinetic law: MODEL1310110008#
product: MODEL1310110008#

metaR HSPGtly
name: heparan sulfate transport, extracellular to lysosome
product: MODEL1310110008#
type: Reaction
reversible: false
is: SBO:0000185
reactant: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110008#

metaM ttdcrn m
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3413344
name: tetradecanoyl carnitine
is: HMDB05066
initial concentration: 1.0
constant: false
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110008#_a91561c3_7522_49ce_a70a_cbbb89b5b0ba
initial amount: NaN
is: Q9NUB1
constant: false
boundary condition: true
name: ACSS1
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:84532
has only substance units: false

metaR EX ddecrn
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lauroyl carnitine
type: Reaction

metaR r0517
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reversible: true
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
fast: false
is: SBO:0000176
modifier: MODEL1310110008#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110008#_96825108_5ae7_4d94_b180_abd2038b6fdc
initial amount: NaN
is: A6NFM2
constant: false
is encoded by: hsa:5831
type: Species
is: SBO:0000252
name: PYCR1
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM acgam c
is: SBO:0000247
name: N-acetyl-D-glucosamine
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:17411
has only substance units: false
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: HMDB00215
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_4c3256b0_134d_4d4c_a592_3369adcfc405
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:197257
name: LDHD
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110008#_4ffa3db1_ae20_419c_a544_68958df09d48
boundary condition: true
is encoded by: hsa:2678
initial concentration: NaN
type: Species
constant: false
is: P19440
is: SBO:0000252
name: GGT1
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_f1bbcc07_4b7f_4f93_8933_83baea5d889e
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaM CE5854 e
constant: false
initial amount: NaN
is: HMDB02710
initial concentration: 1.0
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
is: SBO:0000247
has only substance units: false
name: gama-CEHC-glucuronide
is: CHEBI:27485
boundary condition: false
type: Species

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaM dopa e
is: CHEBI:59905
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: HMDB00073
is: SBO:0000247
name: dopaminium(1+)
has only substance units: false

metaR FAOXC81C61m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

metaM HC02203 e
has only substance units: false
name: prostaglandin-a2
constant: false
is: CHEBI:27820
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR TYRTAm
is: SBO:0000176
reversible: true
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.6.1.5
product: MODEL1310110008#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (6898.1) or (2806.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: PMID:1973834 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.6.1.1
name: tyrosine transaminase, mitochondrial
fast: false

metaM ksi pre14 g
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
name: keratan sulfate I biosynthesis, precursor 14
is: CHEBI:28067
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_22bc6c9d_4062_402b_a787_300ab0a01683
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:65010
constant: false
type: Species
initial concentration: NaN
name: SLC26A6
is: Q9Y3Y1
has only substance units: false
boundary condition: true

metaR HSD17B4x
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
modifier: MODEL1310110008#
type: Reaction
reversible: false
product: MODEL1310110008#
is described by: ECO:0000269
name: hydroxysteroid (17-beta) dehydrogenase 4
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107

metaM sucr e
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00258
name: Sucrose
has only substance units: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00091 EHMN_ABBREVIATION: C00089
is: CHEBI:17992
type: Species
is: C00089
initial amount: NaN

metaM tststerone c
is: SBO:0000247
name: testosterone
is: CHEBI:17347
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
type: Species
is: HMDB00234
boundary condition: false

metaR EX tetdece1crn
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecenoyl carnitine
type: Reaction

metaR CYTDK1
reactant: MODEL1310110008#
type: Reaction
fast: false
product: MODEL1310110008#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.48
kinetic law: MODEL1310110008#
is: SBO:0000176
modifier: MODEL1310110008#
reversible: false
name: ATPcytidine 5-phosphotransferase

http://identifiers.org/biomodels.db/MODEL1310110008#_ccfd79d1_38ed_4fee_b73f_9eabcb51b088
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is: P05166
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:5096
name: PCCB

metaR r2420
product: MODEL1310110008#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110008#_51bcaf60_02c5_48e8_b2c5_827e8c5b6741
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:5833
boundary condition: true
is: F5H8B1
initial concentration: NaN
name: PCYT2
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_39e9bd26_cc3e_4b44_a46e_90cfe6526f5d
boundary condition: true
name: PCCA
is encoded by: hsa:5095
is: C9JPQ8
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_6e38bc87_8d67_4483_9caa_a44795e831ba
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
name: SLC24A4
is encoded by: hsa:123041
initial concentration: NaN
constant: false

metaR RE1691M
fast: false
type: Reaction
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.8.1.1
name: RE1691
reversible: true
modifier: MODEL1310110008#
reactant: MODEL1310110008#

metaR DPHMBDCm
product: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110008#
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate decarboxylation
reactant: MODEL1310110008#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212,PMID:7380842 NOTES:enzyme has not been identified yet IT
reversible: false

metaM q10 e
is: SBO:0000247
name: ubiquinone-10
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:46245
is: HMDB01072
boundary condition: false
initial amount: NaN

metaR RE3421R
is described by: ECO:0000000
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
name: RE3421
type: Reaction
fast: false
reversible: true

metaR PPCOAOm
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
product: MODEL1310110008#
type: Reaction

metaM dtdp c
type: Species
is: C00363
initial concentration: 1.0
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
boundary condition: false
is: CHEBI:58369
name: dTDP
is: SBO:0000247
is: HMDB01274
has only substance units: false
initial amount: NaN
constant: false

metaR BIOCYTtn
name: biocytin transport, nuclear
is: SBO:0000185
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
fast: false
is described by: ECO:0000000
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110008#_8425b599_53c8_41b0_9689_1326e4415641
has only substance units: false
type: Species
is: SBO:0000252
is: Q9NRZ7
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:56894
boundary condition: true
constant: false
name: AGPAT3

http://identifiers.org/biomodels.db/MODEL1310110008#_dd5ca95e_8271_4315_a0d7_3eaffadce731
name: PANK1
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:53354
type: Species
has only substance units: false

metaR DADA
type: Reaction
name: Deoxyadenosine deaminase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.4.4
product: MODEL1310110008#
reactant: MODEL1310110008#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false

metaR S4TASE1ly
kinetic law: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is: SBO:0000176
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.12
modifier: MODEL1310110008#
is described by: ECO:0000000
name: N-acetylgalactosamine-4-sulfatase, lysosomal
reactant: MODEL1310110008#
product: MODEL1310110008#

metaM mpdol U c
has only substance units: false
notes: FORMULA: C1245H2040N20O220P20 CHARGE: -20
boundary condition: false
is: CHEBI:18396
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species

metaM 4mzym int1 r
constant: false
name: 4-Methylzymosterol intermediate 1
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB06927
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_53c9d7b3_f3e0_465f_bc02_af4c3e54dde9
is: O14561
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: NDUFAB1
initial concentration: NaN
is encoded by: hsa:4706

metaR r0813
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:
is: SBO:0000185
modifier: MODEL1310110008#
type: Reaction
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.9
reversible: false
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_4bbe55f8_1121_4553_b567_9cd0373cb2f9
initial concentration: NaN
is encoded by: hsa:5136
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q9Y633
name: PDE1A
constant: false
type: Species
initial amount: NaN

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaR RPE
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
is described by: ECO:0000000
type: Reaction
product: MODEL1310110008#
fast: false
modifier: MODEL1310110008#
reversible: true
is: SBO:0000176
reactant: MODEL1310110008#
name: ribulose 5-phosphate 3-epimerase
is version of: http://identifiers.org/ec-code/5.1.3.1
kinetic law: MODEL1310110008#

metaM dcdp c
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: CHEBI:58593
is: SBO:0000247
has only substance units: false
type: Species
is: C00705
initial amount: NaN
boundary condition: false
is: HMDB01245
name: dCDP
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_1ab95383_ed8f_4722_bd0d_84c712e0b372
is encoded by: hsa:57468
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q9H2X9
constant: false
initial amount: NaN
is: SBO:0000252
name: SLC12A5
type: Species

metaM ocdececrn c
has only substance units: false
name: 11-octadecenoyl carnitine
initial amount: NaN
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C25H47NO4 CHARGE: 0
is: HMDB06351
is: SBO:0000247

metaR FAOXC181C181OHm
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C18:1OH)m
type: Reaction

metaM aps c
is: SBO:0000247
is: CHEBI:58243
boundary condition: false
is: HMDB01003
name: 5'-adenylyl sulfate(2-)
initial amount: NaN
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
constant: false
has only substance units: false
initial concentration: 1.0
type: Species

metaM ksii core2 pre10 g
initial concentration: 1.0
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 10
has only substance units: false
initial amount: NaN
type: Species

metaR THRGLNexR
name: L-threonine/glycine reversible exchange
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
is described by: ECO:0000304
fast: false

metaR BPNT
is described by: ECO:0000269
fast: false
reactant: MODEL1310110008#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.7
name: 3',5'-bisphosphate nucleotidase
modifier: MODEL1310110008#
product: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
is: SBO:0000176
type: Reaction

metaR PYRt2m
product: MODEL1310110008#
is described by: ECO:0000000
modifier: MODEL1310110008#
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
reversible: true
is: SBO:0000185
type: Reaction
name: pyruvate mitochondrial transport via proton symport
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD

http://identifiers.org/biomodels.db/MODEL1310110008#_42f94114_2ba9_405e_a1b7_bf5e5a904df8
boundary condition: true
is: P20594
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:4882
name: NPR2

metaR PItx
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: Phosphate transporter, peroxisome
type: Reaction
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#

metaR LSTO2r
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.21.6
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
product: MODEL1310110008#
modifier: MODEL1310110008#
name: Lathosterol oxidase
fast: false
reversible: false
is described by: ECO:0000269

metaM 5eipencoa m
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
name: 5,8,11,14,17-eicosapentenoylcoa
initial concentration: 1.0

metaR GLUDym
type: Reaction
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/1.4.1.3
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
product: MODEL1310110008#
reactant: MODEL1310110008#
name: glutamate dehydrogenase (NADP), mitochondrial
reversible: true
is described by: ECO:0000269
is: SBO:0000176

metaR SUCCOAPET
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaR GLUPRT
type: Reaction
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.14
name: glutamine phosphoribosyldiphosphate amidotransferase
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110008#
modifier: MODEL1310110008#
reactant: MODEL1310110008#

metaM sql r
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
is: CHEBI:15440
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00256
initial concentration: 1.0
name: squalene
is: SBO:0000247
constant: false
type: Species

metaR IMPC
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110008#
name: IMP cyclohydrolase
modifier: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.1.2.3
is: SBO:0000176
reversible: true
reactant: MODEL1310110008#

metaR SPHS1Pte
is described by: ECO:0000000
name: sphingosine-1-phosphate transport
reactant: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
is: SBO:0000185
reversible: true
product: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_6186456b_e3be_4ce4_8860_ba2ca44a4c00
constant: false
name: OAT
is: P04181
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:4942
initial concentration: NaN

metaM tetdecdicoa x
initial concentration: 1.0
is: SBO:0000247
name: 5,8-tetradecadienoylcoa
has only substance units: false
boundary condition: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
is: HMDB02288
initial amount: NaN
type: Species
constant: false

metaM CE4794 m
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:57923
name: cis-6-dodecenoyl-CoA

metaM btn c
name: Biotin
boundary condition: false
has only substance units: false
is: CHEBI:3420
notes: FORMULA: C10H15N2O3S CHARGE: -1
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: C00120
is: HMDB00030
is: SBO:0000247

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_5c96d551_e34b_4187_9234_1ee7f7de230b
type: Species
is encoded by: hsa:123041
initial concentration: NaN
boundary condition: true
is: Q8NFF2
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: SLC24A4

metaM dtdp e
type: Species
initial concentration: 1.0
is: CHEBI:58369
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274
initial amount: NaN
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_c8e83e17_ffa1_4a97_8880_4602388f68bd
has only substance units: false
constant: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:1716
name: DGUOK
is: SBO:0000252
initial concentration: NaN

metaR TIGCRNe
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tiglyl carnitine into the extra cellular fluid
type: Reaction

metaM nad c
is: HMDB00902
is: http://identifiers.org/pubchem.compound/3305
is: CHEBI:57540
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
name: Nicotinamide adenine dinucleotide
is: C00003
is: SBO:0000247
has only substance units: false

metaR SO4OXAtex2
fast: false
name: sulfate transport via oxalate countertransport (2:1)
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
reversible: false
modifier: MODEL1310110008#
is described by: ECO:0000304
is: SBO:0000185
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
type: Reaction

metaR RE0512M
type: Reaction
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
name: RE0512
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110008#
fast: false

metaR LEUPHELAT2tc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM adp n
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial concentration: 1.0
constant: false
is: HMDB01341
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:456216
name: ADP(3-)
boundary condition: false

metaR RE3241R
reactant: MODEL1310110008#
product: MODEL1310110008#
name: RE3241
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
fast: false
is: SBO:0000176
kinetic law: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
reversible: false

metaR S23T2g
modifier: MODEL1310110008#
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.99.4
is: SBO:0000176
fast: false
kinetic law: MODEL1310110008#
is described by: ECO:0000000
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_208168ec_87e5_4872_9250_e14e994d5309
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q15392
name: DHCR24
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:1718

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaM fadh2 m
has only substance units: false
boundary condition: false
is: CHEBI:58307
constant: false
initial concentration: 1.0
is: HMDB01197
name: Flavin adenine dinucleotide reduced
initial amount: NaN
is: C01352
is: SBO:0000247
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_8d5d10a8_27d8_4611_a569_9de5645b8a36
name: AMACR
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q9UHK6
constant: false
has only substance units: false
is encoded by: hsa:23600

http://identifiers.org/biomodels.db/MODEL1310110008#_8835c3b6_2f8d_4764_b3d1_07c7dba6514d
name: _206_1_c
is encoded by: hsa:206
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_4a2e1af4_a9db_4456_ac04_b6469280cf49
is encoded by: hsa:10195
name: ALG3
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_eb9f5b7f_f184_4e84_a061_6478db9b38e3
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
name: _AI539321_1_c
is encoded by: hsa:AI539321
is: SBO:0000252

metaM adp m
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3310
name: ADP
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: C00008
is: SBO:0000247
is: CHEBI:456216
is: HMDB01341

http://identifiers.org/biomodels.db/MODEL1310110008#_a145a7ab_ec02_45e3_bfd5_b8b575f054ed
constant: false
is: B3KQV3
type: Species
is: SBO:0000252
name: PIP4K2C
is encoded by: hsa:79837
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR 3HCO3 NAt
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
reversible: true
reactant: MODEL1310110008#
name: 3HCO3_NAt
kinetic law: MODEL1310110008#
type: Reaction
is: SBO:0000185
product: MODEL1310110008#

metaR FUMtm
is: SBO:0000185
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
fast: false
product: MODEL1310110008#
reversible: true
name: fumarate transport, mitochondrial

metaR r0060
product: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
is described by: ECO:0000000
reactant: MODEL1310110008#
reversible: false
fast: false
is: SBO:0000176
name: L-serine ammonia-lyase Glycine, serine and threonine metabolism EC:4.3.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.3.1.17 Confidence Level: 0 AUTHORS: PMID:4433562 NOTES:

metaR CO2t
name: CO2 transporter via diffusion
fast: false
type: Reaction
reactant: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
reversible: true
kinetic law: MODEL1310110008#
product: MODEL1310110008#

metaR r0812
is version of: http://identifiers.org/ec-code/2.3.1.41
type: Reaction
modifier: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000185
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
product: MODEL1310110008#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
fast: false

metaM ump c
has only substance units: false
initial concentration: 1.0
is: C00105
initial amount: NaN
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
boundary condition: false
is: SBO:0000247
constant: false
name: UMP
type: Species
is: HMDB00288

metaR DHDPBMTm
is described by: ECO:0000269
product: MODEL1310110008#
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: 2.1.1.114 Confidence Level: 4 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.1.1.114 IT
name: dihydroxydecaprenylbenzoate methyltransferase
reversible: false
reactant: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.1.114
fast: false

metaR FAOXC1811603m
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
type: Reaction
product: MODEL1310110008#
reversible: false
kinetic law: MODEL1310110008#
is described by: ECO:0000269
modifier: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation fatty acid

metaR PYRt2p
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12705896,PMID:12739169,PMID:9786900 NOTES:NCD
reactant: MODEL1310110008#
is: SBO:0000185
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
product: MODEL1310110008#
reversible: true
name: pyruvate peroxisomal transport via proton symport
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_b7a3561a_2d16_49ff_a4fe_2b1844ce6ec7
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:LOC647190
initial amount: NaN
boundary condition: true
name: _LOC647190_1_c
type: Species

metaR MANtly
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
name: mannose efflux from lysosome
product: MODEL1310110008#
reversible: false
type: Reaction

metaM strdnccoa x
is: SBO:0000247
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: HMDB06519
is: C16163
name: stearidonyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205473
initial amount: NaN
has only substance units: false

metaR EX HC01361 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Dihydroneopterin
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_eb1b6235_4f3e_4aae_89c5_0824dc702ee0
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:285973
name: ATG9B
is: Q674R7
has only substance units: false
boundary condition: true

metaR RPI
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
type: Reaction
reversible: true
name: ribose-5-phosphate isomerase
is version of: http://identifiers.org/ec-code/5.3.1.6
is: SBO:0000176
modifier: MODEL1310110008#
product: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
reactant: MODEL1310110008#

metaR ME1m
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.38
reversible: false
modifier: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
is described by: ECO:0000000
name: malic enzyme (NAD), mitochondrial
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110008#_3fd4b9ed_1533_4969_bf28_9929b42a8d63
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is: P48448
constant: false
boundary condition: true
is encoded by: hsa:222
name: ALDH3B2
has only substance units: false

metaR MALTe
is described by: ECO:0000269
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8972.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:3143729 NOTES:IF
is version of: http://identifiers.org/ec-code/3.2.1.20
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000176
name: alpha-glucosidase, extracellular
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110008#_684ad7c4_1869_42ef_a9b5_c36c61044a6a
initial amount: NaN
name: B3GALNT1
type: Species
is: Q8TDY1
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:8706

http://identifiers.org/biomodels.db/MODEL1310110008#_c73eac7e_965c_497a_bab8_1ea6bbfa1a17
is encoded by: hsa:10246
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: O00624
name: SLC17A2
is: SBO:0000252
constant: false
type: Species
has only substance units: false

metaM hestratriol c
constant: false
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB05896
is: SBO:0000247
initial amount: NaN
name: 4,17 dihydroxy estradiol

metaR NACHEX9ly
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
modifier: MODEL1310110008#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110008#
product: MODEL1310110008#

metaM accoa c
is: SBO:0000247
boundary condition: false
is: C00024
has only substance units: false
is: HMDB01206
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
name: Acetyl-CoA
is: CHEBI:57288
initial amount: NaN

metaM 3hexdcoa m
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: 3-hydroxyhexadecanoylcoa
is: C05258
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
initial concentration: 1.0
type: Species
constant: false
is: HMDB03932
boundary condition: false

metaM pro L m
type: Species
is: SBO:0000247
is: CHEBI:17203
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
boundary condition: false
has only substance units: false
name: L-proline
is: HMDB00162
initial concentration: 1.0
initial amount: NaN
constant: false

metaR r0747
is described by: ECO:0000000
kinetic law: MODEL1310110008#
type: Reaction
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
product: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
reactant: MODEL1310110008#
is: SBO:0000176
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:

metaM pail45p hs c
type: Species
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:28910
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
name: phosphatidylinositol 4,5-bisphosphate
is: SBO:0000247

metaM ump e
is: HMDB00288
is: SBO:0000247
type: Species
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:57865
has only substance units: false
name: UMP(2-)
constant: false

metaM trdrd c
is: CHEBI:15967
type: Species
name: Reduced thioredoxin
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
is: C00342

metaR PI345P3Pn
reactant: MODEL1310110008#
modifier: MODEL1310110008#
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, nuclear
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.67
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863,PMID:12728269 NOTES:NCD
product: MODEL1310110008#
reversible: false
kinetic law: MODEL1310110008#
is described by: ECO:0000000

metaR FAS160COA
type: Reaction
kinetic law: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
product: MODEL1310110008#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110008#
name: fatty-acyl-CoA synthase (n-C16:0CoA)

metaR AG13T16g
modifier: MODEL1310110008#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
reactant: MODEL1310110008#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction

metaM dd5ecoa m
name: 5-dodecenoylcoa
initial amount: NaN
is: HMDB13028
is: C01942
has only substance units: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false

metaR SMPD4
kinetic law: MODEL1310110008#
is: SBO:0000176
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
is described by: ECO:0000000
product: MODEL1310110008#
fast: false
reversible: false
type: Reaction
name: sphingomyelinase

metaM c6dc x
name: adipoyl carnitine
type: Species
constant: false
has only substance units: false
is: HMDB04047
is: C14143
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C13H22NO6 CHARGE: -1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_2d177eb5_3bf8_497a_a77c_81fba2eeb49d
initial amount: NaN
name: ALDH3B2
is encoded by: hsa:222
is: SBO:0000252
constant: false
has only substance units: false
type: Species
boundary condition: true
is: P48448
initial concentration: NaN

metaM mmcoa R m
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:57326
has only substance units: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
is: HMDB01269
name: (R)-methylmalonyl-CoA(5-)

http://identifiers.org/biomodels.db/MODEL1310110008#_44419593_46e2_4805_be08_06f33f49f30e
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8818
name: DPM2
is: O94777
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM 3odcoa m
initial amount: NaN
type: Species
is: HMDB03939
is: CHEBI:28528
is: SBO:0000247
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
name: 3-Oxodecanoyl-CoA

metaR r0202
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
reactant: MODEL1310110008#
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110008#
is described by: ECO:0000000
reversible: true
product: MODEL1310110008#

metaR ICDHyrm
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
product: MODEL1310110008#
reactant: MODEL1310110008#
modifier: MODEL1310110008#
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.42
reversible: true
is described by: ECO:0000269
name: Isocitrate dehydrogenase (NADP+)
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_ac1f4f88_5aff_4dde_9051_e8f2ca01b961
boundary condition: true
is: SBO:0000252
has only substance units: false
name: SLC38A5
type: Species
is: Q8WUX1
is encoded by: hsa:92745
initial concentration: NaN
initial amount: NaN
constant: false

metaR r0960
kinetic law: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
reactant: MODEL1310110008#
fast: false
reversible: true

metaM paps c
boundary condition: false
is: CHEBI:58339
is: SBO:0000247
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB01134
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053

metaR 2HBt2
name: 2-hydroxybutyrate cotransport with proton
reversible: true
modifier: MODEL1310110008#
product: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_cfa47356_c0c4_4833_974c_d4ad48d1ed93
constant: false
type: Species
has only substance units: false
name: TM7SF2
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7108
boundary condition: true
is: O76062

metaR NACHEX27ly
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110008#
reversible: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
is: SBO:0000176
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110008#

metaM c226crn m
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
constant: false
has only substance units: false
name: cervonyl carnitine
is: http://identifiers.org/pubchem.compound/127055
initial concentration: 1.0
is: HMDB06510
boundary condition: false

metaM btn e
is: C00120
name: Biotin
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:3420
constant: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: HMDB00030

metaM hestratriol e
name: 4,17 dihydroxy estradiol
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
type: Species
has only substance units: false
boundary condition: false
is: HMDB05896
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false

metaR GULLACter
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES:NCD
kinetic law: MODEL1310110008#
name: gulonolactone endoplasmic reticular transport
is: SBO:0000185

metaM ump g
type: Species
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial concentration: 1.0
boundary condition: false
is: CHEBI:57865
constant: false
is: HMDB00288
is: SBO:0000247
has only substance units: false
name: UMP(2-)

metaM od2coa m
is: HMDB06529
name: trans-Octadec-2-enoyl-CoA
type: Species
is: CHEBI:50570
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h18-19,26-28,32-34,38,49-50H,4-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b19-18+/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE2244

http://identifiers.org/biomodels.db/MODEL1310110008#_67b7abb5_84c4_43f1_9b15_822cccd87900
initial amount: NaN
boundary condition: true
is encoded by: hsa:8611
name: PPAP2A
constant: false
has only substance units: false
is: SBO:0000252
is: G3XA95
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_8bc5927f_bcb5_470e_b654_79a43d1f0cff
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:100128062
name: _100128062_1_m
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

metaM 34dhmald m
is: C05577
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB06242
is: http://identifiers.org/pubchem.compound/7903
is: SBO:0000247
name: 3,4-Dihydroxymandelaldehyde
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
has only substance units: false
type: Species

metaR DCSPTN1t
product: MODEL1310110008#
type: Reaction
name: fatty acid transport via diffusion
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#

metaM pail45p hs n
type: Species
initial concentration: 1.0
name: phosphatidylinositol 4,5-bisphosphate
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:28910
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_b806bc31_8821_43e7_96be_80bd77c84cb1
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is: Q96SL4
name: GPX7
is encoded by: hsa:2882
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_c693422d_439b_45c3_8f84_15f9935d96c9
name: _AI620219_1_c
is: SBO:0000252
type: Species
is encoded by: hsa:AI620219
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true

metaR PItn
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#
is: SBO:0000185
name: phosphate transport, nuclear

metaR r1433
product: MODEL1310110008#
type: Reaction
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110008#
fast: false
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_9ee3c15f_8ab1_43f3_bf35_d8ef41a3cd1d
constant: false
type: Species
is encoded by: hsa:5805
initial amount: NaN
name: PTS
has only substance units: false
initial concentration: NaN
is: Q03393
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_a0deffd1_347e_4bf7_98fc_4a7cd01f8cc1
boundary condition: true
is encoded by: hsa:212
type: Species
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: Q5JZF5
name: ALAS2
is: SBO:0000252

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaM m2emgacpail hs r
type: Species
boundary condition: false
constant: false
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
is: C00080
initial concentration: 1.0
is: CHEBI:24636
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false

metaR sink tetdec2coa LPAREN c RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDEC2COASINK
type: Reaction

metaM q10 m
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB01072
name: ubiquinone-10
is: CHEBI:46245

metaM ddece1crn e
constant: false
is: HMDB02250
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: dodecenoyl carnitine
has only substance units: false
is: SBO:0000247
notes: FORMULA: C19H35NO4 CHARGE: 0

metaM 5tedtricoa m
is: SBO:0000247
type: Species
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
name: 5,8,11-tetradecatrienoylcoa
initial amount: NaN
is: HMDB02288
constant: false
boundary condition: false

metaR FAOXC16180m
name: Beta oxidation fatty acid
type: Reaction
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
reversible: false
fast: false
modifier: MODEL1310110008#
is described by: ECO:0000269
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_f2d09299_7671_4cba_a1d7_c99131d956cb
is: SBO:0000252
constant: false
has only substance units: false
name: SLC22A2
boundary condition: true
initial concentration: NaN
is: O15244
type: Species
initial amount: NaN
is encoded by: hsa:6582

metaM tddedicoa m
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280771
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
name: trans3,6dodecadienoylcoa
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_1e5265bd_1c27_42e1_a14f_7a3fd92f2230
name: PIP5K1A
is: SBO:0000252
is encoded by: hsa:8394
type: Species
initial amount: NaN
boundary condition: true
is: Q99755
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_aae425b4_b020_465a_b163_1f82caffc46a
initial amount: NaN
is: P51687
is: SBO:0000252
is encoded by: hsa:6821
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
constant: false
name: SUOX

metaR AKR1D2
is version of: http://identifiers.org/ec-code/1.3.1.3
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
type: Reaction
reversible: false
modifier: MODEL1310110008#
fast: false
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
is described by: ECO:0000269
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000176

metaR r1434
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
reversible: false
product: MODEL1310110008#
name: Transport reaction
is: SBO:0000185
type: Reaction

metaR r0743
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
modifier: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
reversible: false
product: MODEL1310110008#
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
kinetic law: MODEL1310110008#

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaR G14T6g
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
product: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110008#_17fd93fb_9b11_4cd2_8c94_7570983fd7bc
is encoded by: hsa:5281
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000297
has part: Q6IB04
name: PIGF:PIGO
boundary condition: true
is encoded by: hsa:84720

metaM g1m8masn r
constant: false
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C76H127N2O60X CHARGE: 0
initial concentration: 1.0
initial amount: NaN
type: Species
is: C05875

metaR PHACCOAGLNAC
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
is: SBO:0000176
reactant: MODEL1310110008#
type: Reaction
reversible: false
product: MODEL1310110008#
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
fast: false
kinetic law: MODEL1310110008#

metaM accoa g
has only substance units: false
type: Species
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: CHEBI:57288
constant: false
is: HMDB01206
name: acetyl-CoA(4-)
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM ac m
is: SBO:0000247
boundary condition: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial concentration: 1.0
is: CHEBI:30089
initial amount: NaN
name: acetate
constant: false
type: Species
has only substance units: false
is: HMDB00042

metaR NACHEX16ly
type: Reaction
is: SBO:0000176
modifier: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110008#
is described by: ECO:0000000
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaM dcdp m
initial amount: NaN
is: CHEBI:58593
is: SBO:0000247
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB01245
type: Species
has only substance units: false
name: dCDP(3-)

metaM paps g
is: HMDB01134
is: CHEBI:58339
is: SBO:0000247
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
initial concentration: 1.0
constant: false

metaM ppp9 m
name: Protoporphyrin
type: Species
initial concentration: 1.0
notes: FORMULA: C34H32N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00905 EHMN_ABBREVIATION: C02191
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00241
boundary condition: false
has only substance units: false
is: CHEBI:36159

http://identifiers.org/biomodels.db/MODEL1310110008#_7bd8032a_7575_4416_9aab_6ab120130b75
is: P34896
is encoded by: hsa:6470
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
name: SHMT1
constant: false

metaR FUCtly
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110008#
name: L-fucose efflux from lysosome
reactant: MODEL1310110008#
is described by: ECO:0000000
kinetic law: MODEL1310110008#

metaM acetone m
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB01659
type: Species
name: acetone
is: CHEBI:15347
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM pchol hs m
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16110
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
initial amount: NaN
has only substance units: false
constant: false
name: Phosphatidylcholine
type: Species

metaR NADPtxu
product: MODEL1310110008#
reversible: false
reactant: MODEL1310110008#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ potential for free H NJ
is: SBO:0000185
kinetic law: MODEL1310110008#
is described by: ECO:0000000
name: NADP transporter, peroxisome

metaR ACCOAC
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaR r0744
kinetic law: MODEL1310110008#
fast: false
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
product: MODEL1310110008#
reversible: false
reactant: MODEL1310110008#
is: SBO:0000176

metaR r0311
kinetic law: MODEL1310110008#
reversible: false
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
product: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
reactant: MODEL1310110008#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.9

metaM trdox m
constant: false
is: CHEBI:18191
has only substance units: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
initial concentration: 1.0
boundary condition: false
name: Oxidized thioredoxin
is: SBO:0000247
initial amount: NaN
type: Species

metaR S6T8g
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction
fast: false
product: MODEL1310110008#
reactant: MODEL1310110008#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110008#_42bb4b3b_9c6e_4c70_aeb0_ee2e9c8c96f1
type: Species
has only substance units: false
is encoded by: hsa:509
name: ATP5C1
boundary condition: true
initial amount: NaN
is: Q6I9V2
constant: false
is: SBO:0000252
initial concentration: NaN

metaR HSAT4ly
is: SBO:0000185
product: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
kinetic law: MODEL1310110008#

metaM ddece1crn c
name: dodecenoyl carnitine
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB03712
notes: FORMULA: C19H35NO4 CHARGE: 0
constant: false
initial amount: NaN
type: Species
has only substance units: false

metaR PYRt2r
type: Reaction
reactant: MODEL1310110008#
name: pyruvate reversible transport via proton symport
is: SBO:0000185
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
fast: false
is described by: ECO:0000269
modifier: MODEL1310110008#
reversible: true
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_f7049bbb_fc1d_4ad8_ba21_e6cfc54db98e
type: Species
is encoded by: hsa:51227
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
name: PIGP
is: P57054
constant: false
initial concentration: NaN

metaM dtdp m
is: C00363
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial amount: NaN
is: CHEBI:58369
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
name: dTDP
type: Species
is: HMDB01274
initial concentration: 1.0

metaR FATP2t
reactant: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000269
fast: false
name: fatty acid electroneutral transport
modifier: MODEL1310110008#
reversible: true
type: Reaction
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ

metaM dcdp n
initial amount: NaN
is: CHEBI:58593
is: HMDB01245
initial concentration: 1.0
is: SBO:0000247
name: dCDP(3-)
has only substance units: false
constant: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_17c4daaa_8d68_4f24_92aa_de4d702c65e6
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial concentration: NaN
name: HSD17B2
initial amount: NaN
is: P37059
boundary condition: true
is encoded by: hsa:3294

metaR ALR3
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110008#
is: SBO:0000176
kinetic law: MODEL1310110008#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.21
modifier: MODEL1310110008#
is described by: ECO:0000269
fast: false
name: aldose reductase (acetol)
reversible: false

metaR FAOXC81C61x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)x
type: Reaction

metaM 4mzym int2 r
initial amount: NaN
constant: false
name: 4-Methylzymosterol intermediate 2
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
is: HMDB06838
boundary condition: false
has only substance units: false

metaM pail45p hs m
is: CHEBI:28910
has only substance units: false
constant: false
initial concentration: 1.0
name: phosphatidylinositol 4,5-bisphosphate
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species

metaR CITt4 4
name: citrate transport via sodium symport
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
is: SBO:0000185
type: Reaction
reactant: MODEL1310110008#
is described by: ECO:0000006
fast: false
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reversible: true
modifier: MODEL1310110008#

metaM dmnoncoa c
type: Species
is: HMDB11604
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
constant: false
name: 4,8 dimethylnonanoyl-CoA
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM 3hexdcoa c
is: HMDB03932
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
name: 3-hydroxyhexadecanoylcoa
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
boundary condition: false
is: SBO:0000247
is: C05258

metaM pro L c
initial amount: NaN
is: HMDB00162
boundary condition: false
name: L-proline
is: CHEBI:17203
initial concentration: 1.0
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
constant: false
type: Species
is: SBO:0000247
has only substance units: false

metaM omhpal c
is: HMDB06294
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C16H30O3 CHARGE: -1
has only substance units: false
name: w-hydroxypalmiticacid
is: SBO:0000247

metaR r0399
reactant: MODEL1310110008#
product: MODEL1310110008#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
reversible: true
kinetic law: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.2
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
fast: false
type: Reaction

metaM xyl D c
is: CHEBI:15936
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
name: aldehydo-D-xylose
boundary condition: false

metaM strdnccoa m
is: http://identifiers.org/pubchem.compound/47205473
is: C16163
has only substance units: false
is: HMDB06519
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
type: Species
constant: false
boundary condition: false
name: stearidonyl coenzyme A
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_eeee2c9e_fe89_469d_9520_7e535a5d9aa4
initial concentration: NaN
is encoded by: hsa:51196
is: SBO:0000252
is: Q9P212
type: Species
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
name: PLCE1

metaM dtdp n
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB01274
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: CHEBI:58369

metaM spmd c
is: SBO:0000247
constant: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
has only substance units: false
is: HMDB01257
name: Spermidine
is: CHEBI:57834
is: C00315
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR RE0577C
type: Reaction
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is: SBO:0000176
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000000
kinetic law: MODEL1310110008#
name: RE0577
modifier: MODEL1310110008#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_943db66d_6c0c_42ba_9746_7b4c1ab5d30a
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:10400
is: Q9UBM1
name: PEMT

metaM adp c
is: http://identifiers.org/pubchem.compound/3310
boundary condition: false
is: SBO:0000247
has only substance units: false
name: ADP
is: CHEBI:16761
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB01341
type: Species
is: C00008

metaR C161OHc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecenoylcarnitine
type: Reaction

metaR G6PDH1rer
is: SBO:0000176
product: MODEL1310110008#
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
is version of: http://identifiers.org/ec-code/1.1.1.47
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
reactant: MODEL1310110008#
is described by: ECO:0000269
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#

metaR LNLNCAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110008#
is: SBO:0000185
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110008#
name: fatty acid transport via diffusion
reactant: MODEL1310110008#
is described by: ECO:0000000

metaR IVCOAACBP
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Isovaleryl-CoA from mitochondria into cytosol
type: Reaction

metaR FAOXC18280m
name: Beta oxidation of fatty acid
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
modifier: MODEL1310110008#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:2, transe -> c8:0 - 5 rounds of beta ox, lose 2 degrees of unsat - only 3 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110008#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110008#

metaM succ e
is: SBO:0000247
is: HMDB00254
name: succinate(2-)
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
has only substance units: false
constant: false
type: Species
is: CHEBI:30031

metaM hs deg18 l
initial amount: NaN
constant: false
is: CHEBI:17180
name: heparan sulfate, degradation product 18
is: HMDB01352
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM ump n
is: CHEBI:57865
has only substance units: false
constant: false
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: UMP(2-)

metaM HC00900 c
type: Species
initial amount: NaN
name: Methylmalonate
has only substance units: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
is: CHEBI:30860
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false

metaR H2O2tp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
reactant: MODEL1310110008#
is: SBO:0000185
product: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110008#
name: hydrogen peroxide peroxisomal transport via diffusion

metaM pro L e
is: HMDB00162
is: CHEBI:17203
type: Species
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
boundary condition: false
name: L-proline
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM xyl D e
initial amount: NaN
name: aldehydo-D-xylose
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: CHEBI:15936
is: SBO:0000247
has only substance units: false

metaR CITt4 2
modifier: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
fast: false
kinetic law: MODEL1310110008#
reversible: true
name: citrate transport via sodium symport

metaR EX CE4723 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: neocasomorphin (1-5) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_6d391194_60f6_4ca6_9a4d_f04c5ee43e1c
initial amount: NaN
name: _D29675_1_c
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:D29675
has only substance units: false

metaM occoa c
is: SBO:0000247
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
type: Species
is: HMDB01070
boundary condition: false
is: C01944
initial amount: NaN
constant: false
name: Octanoyl-CoA (n-C8:0CoA)
has only substance units: false
initial concentration: 1.0
is: CHEBI:57386

http://identifiers.org/biomodels.db/MODEL1310110008#_50e5e951_7eaa_468f_96a7_6608b1b248e1
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:514
name: ATP5E
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_7370f0e3_f209_43f4_9e62_af2046f5549d
is: SBO:0000297
is encoded by: hsa:54344
is encoded by: hsa:8813
has part: O94777
name: DPM3:DPM1:DPM2
is encoded by: hsa:8818
has only substance units: false
initial amount: NaN
type: Species
has part: O60762
boundary condition: true
has part: Q86TM7
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_3039949f_1c8e_45fc_964d_86fe077073f1
type: Species
is: P16278
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:2720
boundary condition: true
name: GLB1
initial amount: NaN
initial concentration: NaN

metaR ALR2
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
product: MODEL1310110008#
fast: false
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.21
kinetic law: MODEL1310110008#
name: aldose reductase (methylglyoxal)
reversible: false

metaR MTHFD2
is version of: http://identifiers.org/ec-code/3.5.4.9
is: SBO:0000176
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: true
fast: false
reactant: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
name: methylenetetrahydrofolate dehydrogenase (NAD)
is described by: ECO:0000134

metaM glu5p m
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H8NO7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01092 EHMN_ABBREVIATION: C03287
is: HMDB01228
type: Species
initial concentration: 1.0
name: L-Glutamate 5-phosphate
constant: false
is: CHEBI:58274
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_999537d2_18bd_4905_a36c_c7cf23d16344
has part: A8K7W0
has only substance units: false
has part: O95497
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: VNN3:VNN2:VNN1
constant: false
is encoded by: hsa:8876
is: SBO:0000297
is encoded by: hsa:55350
type: Species
is encoded by: hsa:8875

metaR GARFT
is version of: http://identifiers.org/ec-code/2.1.2.2
fast: false
modifier: MODEL1310110008#
name: phosphoribosylglycinamide formyltransferase
is described by: ECO:0000269
reactant: MODEL1310110008#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
type: Reaction
product: MODEL1310110008#

metaM ump m
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57865
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
name: UMP(2-)
type: Species
is: HMDB00288

metaR SCP2x
fast: false
name: peroxisomal thiolase 2
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways version 2 analog added as per KEGG NJ
is: SBO:0000176
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.3.1.176
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reversible: false
modifier: MODEL1310110008#
is described by: ECO:0000269
type: Reaction

metaM fadh2 r
type: Species
is: SBO:0000247
constant: false
is: HMDB01197
is: CHEBI:58307
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
name: FADH2(2-)
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM succ c
has only substance units: false
initial concentration: 1.0
name: Succinate
is: CHEBI:30031
constant: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: SBO:0000247
is: HMDB00254
is: C00042

metaR r1435
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000000
name: Transport reaction

metaR GPIDA2er
reversible: false
fast: false
kinetic law: MODEL1310110008#
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
modifier: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaM cpppg3 c
name: Coproporphyrinogen III
type: Species
is: HMDB01261
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: C03263
notes: FORMULA: C36H40N4O8 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01085 EHMN_ABBREVIATION: C03263
constant: false
initial amount: NaN
is: CHEBI:57309
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_ab5c0916_a143_40f9_b1db_3aab381dd270
boundary condition: true
is: Q6IBE6
is encoded by: hsa:6484
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
name: ST3GAL4
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_6a3bacf3_cb66_4ab8_a376_439e10011d43
name: ALDH1A3
constant: false
has only substance units: false
is encoded by: hsa:220
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is: P47895

http://identifiers.org/biomodels.db/MODEL1310110008#_99cbd1c6_09cb_4285_a095_0b25d5735b51
constant: false
is encoded by: hsa:6574
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: SLC20A1
is: Q8WUM9

metaR LALDO2x
reactant: MODEL1310110008#
type: Reaction
name: D-Lactaldehyde:NAD+ 1-oxidoreductase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF
modifier: MODEL1310110008#
is: SBO:0000176
product: MODEL1310110008#
reversible: false
fast: false
kinetic law: MODEL1310110008#

metaR r0394
reactant: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
kinetic law: MODEL1310110008#
type: Reaction

metaM 5mthf c
name: 5-Methyltetrahydrofolate
is: C00440
type: Species
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: CHEBI:3729
is: HMDB01396
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR HISD
fast: false
is version of: http://identifiers.org/ec-code/4.3.1.3
name: histidase
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110008#
reversible: false
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
product: MODEL1310110008#
is: SBO:0000176

metaM btn n
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:57586
is: HMDB00030
constant: false
initial amount: NaN
name: biotinate
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120

metaR TSTSTERONESULT
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (6822.1) or (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES:NJ
fast: false
modifier: MODEL1310110008#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110008#
name: testosterone sulfotransferase
is version of: http://identifiers.org/ec-code/2.8.2.14
reversible: false
product: MODEL1310110008#

metaM 3hdececrn c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB02014
notes: FORMULA: C23H43NO5 CHARGE: 0
name: 3-hydroxyhexadecenoylcarnitine
type: Species
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_6a2a6059_62bf_4efe_98d1_20011305a70a
is: SBO:0000252
type: Species
is encoded by: hsa:R14373
name: _R14373_1_x
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_6645030f_2f70_43ef_a7bf_7221a0113845
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
name: SULT1A1
is encoded by: hsa:6817
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110008#_ff85e487_2056_4af3_8f44_151721b55fa1
is: SBO:0000252
is encoded by: hsa:AA576959
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: _AA576959_1_c
boundary condition: true

metaM pa hs c
name: phosphatidate(2-)
is: CHEBI:57739
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR r0741
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
fast: false

metaR H2O2tn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
product: MODEL1310110008#
fast: false
name: hydrogen peroxide nuclear transport
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110008#
reversible: true
kinetic law: MODEL1310110008#

metaR P450SCC1m
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
type: Reaction
product: MODEL1310110008#
reversible: true
is: SBO:0000176
is described by: ECO:0000134
fast: false
name: cholesterol monooxygenase
kinetic law: MODEL1310110008#

metaM trdrd m
boundary condition: false
name: Reduced thioredoxin
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: CHEBI:15967
initial concentration: 1.0
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342

metaM btn m
is: CHEBI:57586
initial amount: NaN
name: biotinate
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00030
constant: false
boundary condition: false
initial concentration: 1.0

metaM rib D e
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB00283
initial amount: NaN
name: D-ribose
is: CHEBI:16988
initial concentration: 1.0
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_d1dc2704_b36d_4136_a8e0_16475685a4ef
initial concentration: NaN
is encoded by: hsa:AI291895
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
name: _AI291895_1_c
type: Species

metaM pram c
is: CHEBI:58681
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: C03090
is: SBO:0000247
initial amount: NaN
is: HMDB01128
boundary condition: false
name: 5-Phospho-beta-D-ribosylamine

metaR PI3P3Pn
product: MODEL1310110008#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110008#
name: phosphatidylinositol-3-phosphate 3-phosphatase, nuclear
reactant: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:EC 3.1.3.- NCD
reversible: false
is: SBO:0000176

metaM hs deg1 l
constant: false
initial concentration: 1.0
name: heparan sulfate, degradation product 1
is: CHEBI:17180
boundary condition: false
is: HMDB01352
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
has only substance units: false
type: Species

metaR PYDAMK
is version of: http://identifiers.org/ec-code/2.7.1.35
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
name: pyridoxamine kinase
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#

metaM ocdececrn m
has only substance units: false
notes: FORMULA: C25H47NO4 CHARGE: 0
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB06351
boundary condition: false
name: 11-octadecenoyl carnitine
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_ca23c430_2f27_499b_9dd4_1b8ef4170fcf
is: Q8TCG5
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:126129
is: SBO:0000252
name: CPT1C
constant: false

metaR FAOXC4C2m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C4-->C2)m
type: Reaction

metaR r2435
is: SBO:0000185
reversible: false
product: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3

metaM rib D c
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
has only substance units: false
boundary condition: false
type: Species
name: D-ribose
is: CHEBI:16988
is: HMDB00283
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_e39b3d39_6ab7_4e06_ad82_b22693c9b253
is encoded by: hsa:4846
initial concentration: NaN
name: NOS3
is: A0S0A7
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species

metaR DDECE1CRNe
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of dodecenoyl carnitine into extra cellular space
type: Reaction

metaR SEBCOAPET
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaM ei11ecoa x
initial amount: NaN
boundary condition: false
name: 11-eicosenoylcoa
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
type: Species

metaR MALtm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
reactant: MODEL1310110008#
reversible: true
type: Reaction
product: MODEL1310110008#
is: SBO:0000185
fast: false
name: malate transport, mitochondrial
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000269

metaM hmgcoa x
constant: false
type: Species
has only substance units: false
boundary condition: false
is: HMDB01375
name: Hydroxymethylglutaryl-CoA
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial concentration: 1.0
is: CHEBI:15467

metaM 3thexddcoacrn e
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
is: HMDB02014
notes: FORMULA: C23H41NO5 CHARGE: 0
is: SBO:0000247
constant: false
type: Species

metaM 3tdcrn c
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C21H41NO5 CHARGE: 0
is: SBO:0000247
type: Species
initial amount: NaN
name: 3-hydroxy-tetradecanoyl carnitine
is: HMDB02014

metaR BDMT U
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
fast: false
is: SBO:0000176
product: MODEL1310110008#
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)
is version of: http://identifiers.org/ec-code/2.4.1.142
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110008#
is described by: ECO:0000000

metaM 3hdececrn e
boundary condition: false
is: HMDB12930
constant: false
initial amount: NaN
initial concentration: 1.0
name: 3-hydroxyhexadecenoylcarnitine
notes: FORMULA: C23H43NO5 CHARGE: 0
has only substance units: false
type: Species
is: SBO:0000247

metaM acetone c
is: CHEBI:15347
name: acetone
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB01659
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207

http://identifiers.org/biomodels.db/MODEL1310110008#_4be28294_aba9_446f_b9d8_9c82cd417154
is: Q9UMR5
constant: false
initial amount: NaN
name: PPT2
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:9374

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

metaR NODe
name: NODe
kinetic law: MODEL1310110008#
reversible: true
is: SBO:0000185
product: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110008#
fast: false
is described by: ECO:0000134

metaR APOCF
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
name: Apocarboxylase formation
is: SBO:0000176
product: MODEL1310110008#
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_e5ee6a7e_316f_471c_9dd8_0672cfbce9d7
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaM ac c
constant: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: HMDB00042
is: SBO:0000247
has only substance units: false
name: acetate
type: Species
is: CHEBI:30089
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR EX crvnc LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC22:6 exchange
type: Reaction

metaR SIAASE4ly
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110008#
product: MODEL1310110008#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
kinetic law: MODEL1310110008#
name: sialidase, lysosomal

metaM s2l2n2m2masn l
constant: false
name: de-Fuc form of PA6
boundary condition: false
initial amount: NaN
is: CHEBI:18287
is: HMDB00174
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C84H135N6O61X CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110008#_0a7d57b6_6604_4d59_8d42_c1e54eccd74d
is encoded by: hsa:BE042354
is: SBO:0000252
type: Species
has only substance units: false
constant: false
name: _BE042354_1_m
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR CYTDt
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is: SBO:0000185
product: MODEL1310110008#
name: cytidine facilated transport in cytosol
type: Reaction
reactant: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000269
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_7fc98343_ab2f_4207_a710_daee4403c799
boundary condition: true
name: PLCD4
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:84812
is: Q9BRC7
constant: false
initial amount: NaN
initial concentration: NaN

metaM sprm e
constant: false
is: CHEBI:45725
initial concentration: 1.0
boundary condition: false
name: spermine(4+)
is: HMDB01256
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR FADDPle
type: Reaction
notes: GENE_ASSOCIATION: (5167.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000176
fast: false
reversible: false
name: FAD diphosphatase
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.4.1
is described by: ECO:0000134
product: MODEL1310110008#
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_b73403dc_69dd_4c79_9b7c_934f953a69af
is encoded by: hsa:3613
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
name: IMPA2
is: O14732
initial concentration: NaN
initial amount: NaN
type: Species

metaR FAOXC10C8x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

metaR r0527
fast: false
product: MODEL1310110008#
type: Reaction
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
kinetic law: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:

metaR r1292
name: Postulated transport reaction
kinetic law: MODEL1310110008#
is described by: ECO:0000000
reactant: MODEL1310110008#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction
product: MODEL1310110008#
reversible: true

metaR DPPS
type: Reaction
name: decaprenyl synthase
kinetic law: MODEL1310110008#
product: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 2 AUTHORS: PMID:16262699 NOTES:by analogy to other dimethyl transferase rxns. See PMID: 10586494, human interemidate (from C15 ->C50) not explicitly determined yet, however it is known to occur since this pathway is essential in Q10 synthesis. For human metabolism: may be associated w/ GeneID: 23590 TPRT - recheck lit in future IT and NJ
is described by: ECO:0000134
reversible: false
is: SBO:0000176

metaR SPHS1Ptr
is described by: ECO:0000000
reactant: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
kinetic law: MODEL1310110008#
name: sphingosine-1-phosphate transport
product: MODEL1310110008#
type: Reaction
is: SBO:0000185
fast: false

metaR MERCPLACCYSt
kinetic law: MODEL1310110008#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
reactant: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000000
name: 3-mercaptolactate-cysteine disulfide transport, extracellular
type: Reaction

metaM ksi deg37 l
initial concentration: 1.0
is: HMDB01354
type: Species
constant: false
is: SBO:0000247
name: keratan sulfate I, degradation product 37
boundary condition: false
has only substance units: false
notes: FORMULA: C62H104N4O46 CHARGE: 0
initial amount: NaN
is: CHEBI:57455

metaM acetone e
has only substance units: false
boundary condition: false
name: acetone
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
initial amount: NaN
is: HMDB01659
is: CHEBI:15347

metaM ac e
is: CHEBI:30089
is: SBO:0000247
initial amount: NaN
name: acetate
constant: false
type: Species
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
has only substance units: false
initial concentration: 1.0
is: HMDB00042
boundary condition: false

metaM xyl D l
initial concentration: 1.0
name: aldehydo-D-xylose
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:15936
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_993fe099_ef97_413c_917f_5249df4a94bc
initial concentration: NaN
name: ALDH7A1
is: E7EPT3
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:501

metaM 4pyrdx c
is: HMDB00017
initial concentration: 1.0
boundary condition: false
type: Species
name: 4-pyridoxate
initial amount: NaN
constant: false
notes: FORMULA: C8H9NO4 CHARGE: 0 INCHI: InChI=1S/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)/p-1 EHMN_ABBREVIATION: C00847
is: CHEBI:30959
has only substance units: false
is: SBO:0000247

metaR r2439
kinetic law: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12759755 NOTES:
type: Reaction
product: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
is: SBO:0000185
name: Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP), TCDB:2.A.53.2.2
reversible: false

metaM pa hs m
name: phosphatidate(2-)
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:57739
is: SBO:0000247
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
initial concentration: 1.0
has only substance units: false
type: Species

metaR SERGLYexR
product: MODEL1310110008#
modifier: MODEL1310110008#
reversible: true
type: Reaction
kinetic law: MODEL1310110008#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110008#
fast: false
name: L-Serine/Glycine reversible exchange
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110008#_79220da5_b779_4d13_810c_3a5c2a89ef56
initial amount: NaN
is encoded by: hsa:7389
is: P06132
initial concentration: NaN
name: UROD
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
type: Species

metaR AHEXASE2ly
fast: false
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110008#_de9c89cf_7e13_433e_85a2_1be486733858
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:10476
type: Species
name: ATP5H
initial concentration: NaN
is: O75947

metaR ADCim
product: MODEL1310110008#
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
is: SBO:0000176
kinetic law: MODEL1310110008#
name: Acetoacetate decarboxylation (irreversible), mitochondrial
is described by: ECO:0000000

metaR P4508B13r
reactant: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reversible: false
product: MODEL1310110008#
fast: false
name: sterol 12-alpha-hydroxylase (nadh)
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.14.13.95
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)

metaM 3dpdhb m
notes: FORMULA: C57H85O4 CHARGE: -1 INCHI: InChI=1S/C57H86O4/c1-43(2)21-12-22-44(3)23-13-24-45(4)25-14-26-46(5)27-15-28-47(6)29-16-30-48(7)31-17-32-49(8)33-18-34-50(9)35-19-36-51(10)37-20-38-52(11)39-40-53-41-54(57(60)61)42-55(58)56(53)59/h21,23,25,27,29,31,33,35,37,39,41-42,58-59H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,60,61)/b44-23+,45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+
initial amount: NaN
initial concentration: 1.0
is: CHEBI:50775
constant: false
name: 3-Decaprenyl-4,5-dihdydroxybenzoate
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_4184d5e6_531a_46ed_94c2_52d3a7cb4e38
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: Q7KYS4
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5143
name: PDE4C

metaR PETOHMm hs
is: SBO:0000176
kinetic law: MODEL1310110008#
name: phosphatidylethanolamine N-methyltransferase
reactant: MODEL1310110008#
fast: false
modifier: MODEL1310110008#
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.1.17
is described by: ECO:0000254
reversible: false
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ

http://identifiers.org/biomodels.db/MODEL1310110008#_1319e864_d5bd_4da4_aeb9_8eaa86aeb568
initial concentration: NaN
is encoded by: hsa:160728
constant: false
boundary condition: true
is: SBO:0000252
name: SLC5A8
is: Q8N695
has only substance units: false
initial amount: NaN
type: Species

metaR r0317
reactant: MODEL1310110008#
fast: false
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.1.2.10
is version of: http://identifiers.org/ec-code/1.8.1.4
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.4.4.2
reversible: true

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

metaM tyr L e
is: CHEBI:17895
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: HMDB00158
has only substance units: false
name: L-tyrosine
constant: false
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR r1299
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110008#
is: SBO:0000185
fast: false
name: Vesicular transport
type: Reaction
product: MODEL1310110008#
kinetic law: MODEL1310110008#

metaM trdox c
is: CHEBI:18191
initial amount: NaN
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
name: Oxidized thioredoxin
is: C00343
boundary condition: false

metaM hestratriol r
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
type: Species
is: SBO:0000247
boundary condition: false
name: 4,17 dihydroxy estradiol
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB05896

metaM fadh2 x
name: FADH2(2-)
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB01197
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: CHEBI:58307
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM 4pyrdx e
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
name: 4-pyridoxate
is: CHEBI:30959
notes: FORMULA: C8H9NO4 CHARGE: 0 INCHI: InChI=1S/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)/p-1 EHMN_ABBREVIATION: C00847
has only substance units: false
is: SBO:0000247
is: HMDB00017

http://identifiers.org/biomodels.db/MODEL1310110008#_d7bc6ddb_b070_4870_8f71_bec222d762bf
has only substance units: false
is encoded by: hsa:3945
is: P07195
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
name: LDHB

metaR CRNtim
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
name: L-carnitine transport out of mitochondria via diffusion
product: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
fast: false
reactant: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000269
reversible: false

metaR BILIRUBtr
fast: false
name: lipid, flip-flop intracellular transport
product: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ

metaR r0523
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
modifier: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
fast: false
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000
is: SBO:0000176

metaR r1298
is: SBO:0000185
reversible: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
name: Vesicular transport
fast: false
is described by: ECO:0000000

metaR SUCOASm
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
name: Succinate--CoA ligase (ADP-forming)
type: Reaction
product: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.4
modifier: MODEL1310110008#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.5
reversible: true

metaR OCD11CRNCACT
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaM CE1944 c
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
initial concentration: 1.0
initial amount: NaN
is: CHEBI:36781
name: 1-pyrrolinium
is: SBO:0000247
boundary condition: false
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_b731b1f2_165e_4498_b6dd_40582043b01e
name: PDE6A:PDE6C:PDE6D:PDE6G:PDE6B
has only substance units: false
is encoded by: hsa:5148
is: SBO:0000297
constant: false
is encoded by: hsa:5147
initial amount: NaN
initial concentration: NaN
has part: O43924
type: Species
has part: P18545
boundary condition: true

metaM malthp e
name: maltoheptaose
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: C01936
boundary condition: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
is: http://identifiers.org/pubchem.compound/5041

metaM cit m
is: SBO:0000247
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: C00158
initial concentration: 1.0
constant: false
name: Citrate
is: CHEBI:16947
initial amount: NaN
is: HMDB00094
type: Species
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_67dd9b65_8884_4243_a8c6_b2e1fdacecc3
is encoded by: hsa:AI348006
constant: false
name: _AI348006_1_c
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaM c101coa c
name: decenoylcoa
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247
is: HMDB00651

metaM glu5sa m
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
name: L-Glutamate 5-semialdehyde
initial concentration: 1.0
is: HMDB02104
has only substance units: false
is: C01165
boundary condition: false
initial amount: NaN
is: CHEBI:17232

metaM eicostetcoa c
type: Species
is: SBO:0000247
boundary condition: false
name: eicosatetranoyl coenzyme A
has only substance units: false
is: C16164
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
constant: false

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_875bdf9c_9d00_4e61_81e4_0d9b766d2d5d
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:79071
name: ELOVL6
type: Species
is: SBO:0000252
is: Q9H5J4
has only substance units: false
boundary condition: true

metaM nadp c
has only substance units: false
is: HMDB00217
is: SBO:0000247
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
constant: false
is: C00006
type: Species
is: CHEBI:58349
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate
initial amount: NaN
boundary condition: false

metaM tyr L c
has only substance units: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
name: L-tyrosine
is: CHEBI:17895
is: HMDB00158
type: Species
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR r0522
product: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10

metaR ASNtm
product: MODEL1310110008#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110008#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
is: SBO:0000185
fast: false
name: L-asparagine transport, mitochondrial
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_592997af_f5fb_424e_b90d_1b96c56d1205
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: EARS2
boundary condition: true
is: Q5JPH6
constant: false
is encoded by: hsa:124454
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_b769f3bc_4e52_4846_b1f9_b1f340af051e
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: _U37519_1_e
initial amount: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:U37519

metaR THMP
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD
reactant: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: thiamin phosphatase
reversible: false

metaR SPRMTDe
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: Larqu? E, Sabater-Molina M, Zamora S. (2007). Nutrition 23: 87-95, PMID: 11564949. NOTES:polyamines are taken up by diffusion process, although specific carriers and para-cellular transport has also been documented.
kinetic law: MODEL1310110008#
is described by: ECO:0000134
product: MODEL1310110008#
fast: false
type: Reaction
name: absorption for spermine across the basolateral side
is: SBO:0000185
reactant: MODEL1310110008#

metaR r0055
type: Reaction
product: MODEL1310110008#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.2.7
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
reversible: true
is: SBO:0000176
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.2.8
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_37a9491c_96ad_4500_ac57_152f01672db5
is: SBO:0000252
is: O60760
has only substance units: false
name: HPGDS
type: Species
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:27306
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_8c3c5a70_d791_4c96_92b1_172dcfc4c791
initial amount: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: B4DK61
name: ACOX1
is encoded by: hsa:51

metaR r2508
reversible: true
type: Reaction
kinetic law: MODEL1310110008#
is described by: ECO:0000000
reactant: MODEL1310110008#
name: Utilized transport
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_da18f128_4e09_45e4_8c10_4dcc83614b17
initial concentration: NaN
has only substance units: false
is encoded by: hsa:515
constant: false
initial amount: NaN
is: SBO:0000297
type: Species
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
boundary condition: true

metaR DNDPt42m
product: MODEL1310110008#
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dUTP transport via ADP antiport
reversible: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110008#
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_cc5f36ea_6bce_4021_a5e0_baf15a5a34e5
is: Q16698
boundary condition: true
has only substance units: false
is encoded by: hsa:1666
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: DECR1
type: Species

metaM CE5132 c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
type: Species
is: CHEBI:57923
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132

http://identifiers.org/biomodels.db/MODEL1310110008#_88226ce3_e58e_4446_bafa_a5bf47c312a3
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:R33828
has only substance units: false
type: Species
name: _R33828_1_c
boundary condition: true
initial concentration: NaN

metaR S6TASE9ly
reactant: MODEL1310110008#
name: N-acetylgalactosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110008#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: true
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false

metaR r2509
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110008#
reversible: true
name: Utilized transport
type: Reaction
kinetic law: MODEL1310110008#
is described by: ECO:0000000
reactant: MODEL1310110008#

metaM xtsn c
is: CHEBI:18107
constant: false
name: xanthosine
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00299
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_3c499303_c2a2_4582_a48a_3562710f9d87
boundary condition: true
name: TPI1P2
is encoded by: hsa:286016
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
type: Species

metaM dump n
boundary condition: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
name: dUMP(2-)
is: SBO:0000247
is: CHEBI:246422
type: Species
initial concentration: 1.0
is: HMDB01409
initial amount: NaN
constant: false
has only substance units: false

metaR r0208
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/4.4.1.1
modifier: MODEL1310110008#
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
reactant: MODEL1310110008#
product: MODEL1310110008#
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13

metaR FAOXC183C163Gm
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

metaM CE5788 e
is: SBO:0000247
name: kinetensin 1-7
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: HMDB02710
initial concentration: 1.0
is: CHEBI:27485

http://identifiers.org/biomodels.db/MODEL1310110008#_0a1c231f_ca2b_48f8_84f3_04bc901640d4
is encoded by: hsa:7086
boundary condition: true
is: E7EPA7
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
name: TKT
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_548a4b3b_d93f_433b_b0ce_7b980fe0bcaf
boundary condition: true
is: B3KTV4
constant: false
is encoded by: hsa:122622
has only substance units: false
name: ADSSL1
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM bhb c
is: HMDB00011
is: CHEBI:10983
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
has only substance units: false
boundary condition: false
is: SBO:0000247
name: (R)-3-hydroxybutyrate

metaM eicostetcoa m
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
has only substance units: false
is: C16164
initial concentration: 1.0
is: SBO:0000247
name: eicosatetranoyl coenzyme A
type: Species
constant: false
initial amount: NaN

metaM memgacpail hs r
constant: false
has only substance units: false
boundary condition: false
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:15809
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_3baee442_c570_4558_ad7b_22e82dd29853
constant: false
initial amount: NaN
is encoded by: hsa:57665
is: SBO:0000252
is: Q9HBH5
has only substance units: false
initial concentration: NaN
type: Species
name: RDH14
boundary condition: true

metaR GCALDD
is version of: http://identifiers.org/ec-code/1.2.1.36
fast: false
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110008#
is: SBO:0000176
modifier: MODEL1310110008#
product: MODEL1310110008#
name: Glycolaldehyde dehydrogenase
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR

metaR 3MOBt2im
reversible: false
reactant: MODEL1310110008#
is described by: ECO:0000000
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
product: MODEL1310110008#
fast: false
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport
is: SBO:0000185
type: Reaction

metaR FAOXC10C8m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_7e1ac7d5_d304_4a68_b2d1_5ebac5a4a74c
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P49247
type: Species
name: RPIA
is encoded by: hsa:22934
has only substance units: false

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaM s2l2n2m2masn e
constant: false
name: de-Fuc form of PA6
initial amount: NaN
is: SBO:0000247
is: CHEBI:3554
notes: FORMULA: C84H135N6O61X CHARGE: -2
type: Species
is: C00255
is: HMDB00244
has only substance units: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_844e3913_4cc3_482f_aa78_a790ea14033e
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is: B7Z792
name: NDUFS2
is encoded by: hsa:4720
has only substance units: false

metaR r0809
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:
name: Facilitated diffusion
kinetic law: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110008#
type: Reaction
reversible: true
reactant: MODEL1310110008#
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false

metaR UGLCNACtg
type: Reaction
is: SBO:0000185
name: UDP-GlcNAc Golgi transport via CMP antiport
fast: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000269
reversible: true
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110008#_64bf2c89_6b75_4b9a_a0d3_a21e373ee3dd
has only substance units: false
name: DHCR24
is encoded by: hsa:1718
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is: Q15392
initial amount: NaN

metaR 34HPLFM
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
fast: false
type: Reaction
name: 3-(4-hydroxyphenyl-)lactate formation

metaR FAOXC226C205m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

metaM nrvnccoa c
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
name: nervonyl coenzyme A
type: Species
is: SBO:0000247
is: C16532
constant: false
boundary condition: false

metaM elaidcrn c
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
name: Elaidic carnitine
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: HMDB06464
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_27013a57_bcf5_47e2_85f8_312b12cbf8ff
initial concentration: NaN
boundary condition: true
name: _AI915649_1_c
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI915649
type: Species

metaM fe3 e
constant: false
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
is: CHEBI:29034
is: HMDB12943
name: Fe3+
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_a8b0e2a0_83e5_42eb_8df0_966379510871
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false
name: _AI934540_1_c
is encoded by: hsa:AI934540

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

metaM CE1926 e
is: SBO:0000247
is: CHEBI:15748
name: gama-carboxyethyl-hydroxychroman
boundary condition: false
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
is: HMDB00127
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_750445f5_2e76_46cd_9055_cdea3aad7f03
name: ACADSB
type: Species
constant: false
initial concentration: NaN
is: P45954
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:36

metaR RE2426C
type: Reaction
name: RE2426
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:
product: MODEL1310110008#
reversible: true
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false

metaM m2mpdol U c
type: Species
boundary condition: false
constant: false
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: CHEBI:28049
notes: FORMULA: C1365H2240N20O320P20 CHARGE: -20
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_eedd3c28_984e_422b_9ae0_a04c1823f49d
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2592
is: B4E097
is: SBO:0000252
name: GALT
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaM omhpal r
type: Species
is: HMDB06294
constant: false
name: w-hydroxypalmiticacid
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C16H30O3 CHARGE: -1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_e72c4744_2937_4723_8df7_cdf9c1dc628f
boundary condition: true
is: O75912
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:9162
name: DGKI
initial amount: NaN

metaR COQ3m
is: SBO:0000176
type: Reaction
reactant: MODEL1310110008#
is described by: ECO:0000269
fast: false
product: MODEL1310110008#
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
name: methyltransferase COQ3
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10777520,PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_2.1.1.114 IT
reversible: false
is version of: http://identifiers.org/ec-code/2.1.1.114

metaR SPTix
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (189.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:10960483,PMID:9783918 NOTES:
name: serine-pyruvate aminotransferase (irreversible), peroxisomal
fast: false
kinetic law: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110008#
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.6.1.44
modifier: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_ec92b987_d8b0_47f5_a1f8_b8a0e0e137ca
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q9Y6T7
name: DGKB
is encoded by: hsa:1607
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110008#_0b5481a4_3374_4e63_ade9_f5780aeb64dc
initial amount: NaN
is: F8WDN9
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:27068
is: SBO:0000252
name: PPA2
type: Species
initial concentration: NaN

metaM 5tedtricoa x
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
initial concentration: 1.0
name: 5,8,11-tetradecatrienoylcoa
is: HMDB02288
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_114d7f8d_d7fe_4800_987a_ca29dc65fb16
boundary condition: true
constant: false
initial concentration: NaN
type: Species
name: NDUFB9
initial amount: NaN
is encoded by: hsa:4715
is: Q9Y6M9
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110008#_af7f35ef_6828_4dfe_b920_0564b67d64f4
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:1586
name: CYP17A1
is: P05093
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true

metaM cit c
has only substance units: false
type: Species
is: CHEBI:16947
initial concentration: 1.0
is: C00158
boundary condition: false
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
name: Citrate
is: HMDB00094
initial amount: NaN
is: SBO:0000247

metaR BTNtn
is: SBO:0000185
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
name: Biotin transport, nuclear
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
product: MODEL1310110008#

metaM CE0849 m
is: SBO:0000247
boundary condition: false
is: CHEBI:57795
initial amount: NaN
name: cis,cis-palmito-7,10-dienoyl-CoA
type: Species
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
has only substance units: false
constant: false
initial concentration: 1.0

metaR RE1519M
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE1519
modifier: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
product: MODEL1310110008#
is described by: ECO:0000000
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.13

metaR PROD2m
product: MODEL1310110008#
name: Proline dehydrogenase (m)
modifier: MODEL1310110008#
is: SBO:0000176
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
is version of: http://identifiers.org/ec-code/1.5.99.8
reversible: false
type: Reaction
reactant: MODEL1310110008#

metaM dmpp x
is: HMDB01120
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:57623
constant: false
boundary condition: false
name: prenyl diphosphate(3-)
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_a8f90408_be4e_4ae1_8152_da00dedfce1e
constant: false
is: Q16348
initial concentration: NaN
initial amount: NaN
name: SLC15A2
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6565

metaR S6T15g
is described by: ECO:0000000
kinetic law: MODEL1310110008#
reversible: false
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.8.2.17
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.8.2.21
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110008#

metaM sprm c
name: spermine(4+)
is: SBO:0000247
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
boundary condition: false
initial amount: NaN
type: Species
is: HMDB01256
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:45725

metaR NH4t3r
is described by: ECO:0000269
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000185
name: ammonia transport via proton antiport
fast: false
reactant: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:

metaR URCN
reactant: MODEL1310110008#
name: URCN
is version of: http://identifiers.org/ec-code/4.2.1.49
product: MODEL1310110008#
modifier: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR C204CPT2
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
reversible: false
is: SBO:0000176
reactant: MODEL1310110008#
modifier: MODEL1310110008#
product: MODEL1310110008#
name: arachidonic acid transport into the mitochondria
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
is described by: ECO:0000000
type: Reaction

metaR PRODt2r
reactant: MODEL1310110008#
name: D-proline reversible transport via proton symport
reversible: true
is: SBO:0000185
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
product: MODEL1310110008#
type: Reaction
fast: false
is described by: ECO:0000304

metaR FAOXC221C201x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

metaR CMPSASn
type: Reaction
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.7.43
kinetic law: MODEL1310110008#
name: CMP sialic acid synthase, nuclear
product: MODEL1310110008#
reactant: MODEL1310110008#
modifier: MODEL1310110008#
fast: false

metaR ORNt4m
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
name: ornithine mitochondrial transport exchange with citruline
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
reversible: true
product: MODEL1310110008#
is described by: ECO:0000269
modifier: MODEL1310110008#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110008#_fc0b706f_88bc_4f0e_a518_1da8aaaecb4d
initial concentration: NaN
is: P31350
initial amount: NaN
has only substance units: false
boundary condition: true
name: RRM2
type: Species
is encoded by: hsa:6241
is: SBO:0000252
constant: false

metaM fe3 c
boundary condition: false
is: HMDB12943
type: Species
has only substance units: false
is: SBO:0000247
name: Fe3+
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: Fe CHARGE: 3

metaR r1291
kinetic law: MODEL1310110008#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110008#
fast: false
product: MODEL1310110008#
name: Postulated transport reaction
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaR NADS2
is version of: http://identifiers.org/ec-code/6.3.5.1
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110008#
fast: false
modifier: MODEL1310110008#
name: NAD synthase (glutamine-hydrolysing)
kinetic law: MODEL1310110008#
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110008#
is described by: ECO:0000269

metaM ppbng c
is: CHEBI:58126
boundary condition: false
is: C00931
has only substance units: false
constant: false
notes: FORMULA: C10H13N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00588 EHMN_ABBREVIATION: C00931
type: Species
is: SBO:0000247
name: Porphobilinogen
is: HMDB00245
initial concentration: 1.0
initial amount: NaN

metaM cdp e
type: Species
is: CHEBI:58069
is: SBO:0000247
initial concentration: 1.0
name: CDP(3-)
boundary condition: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: HMDB01546
initial amount: NaN
has only substance units: false
constant: false

metaR RE2541E
fast: false
product: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000000
name: RE2541
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000176
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31

metaR ABUTD
name: Aminobutyraldehyde dehydrogenase
reversible: false
product: MODEL1310110008#
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110008#
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110008#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110008#_d851e36f_6171_492d_89cb_5b7df6564e14
name: PGK2
type: Species
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:5232
initial amount: NaN
is: P07205
initial concentration: NaN
is: SBO:0000252

metaM bilirub c
is: CHEBI:57977
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
has only substance units: false
is: HMDB00054
constant: false
name: bilirubin(2-)
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_1f4ccba2_859b_45ee_bc79_2071ad81620b
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
name: _728637_1_c
type: Species
initial amount: NaN
is encoded by: hsa:728637
is: SBO:0000252

metaM nm2masn g
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C42H70N3O30X CHARGE: 0
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
boundary condition: false
is: SBO:0000247
is: C05884
constant: false
has only substance units: false
type: Species

metaR OAGD3tg
is described by: ECO:0000000
product: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
is: SBO:0000185
name: oagd3 hs intracellular transport
type: Reaction
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110008#_24875032_c5d7_4488_8474_58198fc77940
name: PDXK
is encoded by: hsa:8566
constant: false
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: O00764

metaR CYTDK2m
product: MODEL1310110008#
is: SBO:0000176
kinetic law: MODEL1310110008#
fast: false
type: Reaction
name: cytidine kinase (ATP), mitochondrial
reversible: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
is described by: ECO:0000000

metaR EX 3tdcrn
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-tetradecanoyl carnitine
type: Reaction

metaR GGLUCT
name: gamma-glutamylcyclotransferase
reversible: false
is version of: http://identifiers.org/ec-code/2.3.2.4
modifier: MODEL1310110008#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
type: Reaction
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000269
reactant: MODEL1310110008#

metaM tyr L m
constant: false
type: Species
is: HMDB00158
is: CHEBI:17895
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: L-tyrosine
initial concentration: 1.0
has only substance units: false

metaR DRBK
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.15 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
fast: false
is: SBO:0000176
name: Deoxyribokinase
is described by: ECO:0000304
product: MODEL1310110008#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.15
modifier: MODEL1310110008#

metaM cit e
type: Species
is: CHEBI:16947
has only substance units: false
name: citrate(3-)
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: HMDB00094
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_427c660b_41f8_4a61_a50f_3265dacf2a6e
has only substance units: false
constant: false
is encoded by: hsa:2877
is: P18283
boundary condition: true
is: SBO:0000252
name: GPX2
initial amount: NaN
initial concentration: NaN
type: Species

metaM 3tdcrn e
boundary condition: false
is: HMDB13336
notes: FORMULA: C21H41NO5 CHARGE: 0
name: 3-hydroxy-tetradecanoyl carnitine
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_70a2e57f_a38c_43da_ae08_7053afffa59a
boundary condition: true
is encoded by: hsa:6389
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is: P31040
constant: false
name: SDHA

http://identifiers.org/biomodels.db/MODEL1310110008#_6e14c66e_4d9c_4585_8f19_ac200b44f57d
is: SBO:0000252
name: NPR2
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4882
constant: false

metaM glygn4 e
is: HMDB00122
notes: FORMULA: C18H31O16X CHARGE: 0
initial amount: NaN
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
is: SBO:0000247
is: CHEBI:4167
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false

metaM glyclt c
has only substance units: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: HMDB00115
is: CHEBI:29805
name: glycolate

metaM 5hoxindoa c
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:27823
notes: FORMULA: C10H8NO3 CHARGE: -1 INCHI: InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14) HEPATONET_1.0_ABBREVIATION: HC01537 EHMN_ABBREVIATION: C05635
type: Species
name: 5-Hydroxyindoleacetate
is: SBO:0000247
is: HMDB00763
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_f7a0d389_3239_4cb6_a75b_c1ce16a42143
has only substance units: false
type: Species
name: OGDH
is: Q02218
is encoded by: hsa:4967
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true

metaM fol c
notes: FORMULA: C19H18N7O6 CHARGE: -1
name: Folate
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00121
is: SBO:0000247

metaM 3thexddcoacrn c
is: HMDB02014
constant: false
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C23H41NO5 CHARGE: 0
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_df99b281_fc42_4077_9111_ba7b4f2d71a9
is: Q9H3H5
initial amount: NaN
is: SBO:0000252
name: DPAGT1
has only substance units: false
is encoded by: hsa:1798
boundary condition: true
initial concentration: NaN
constant: false
type: Species

metaM ksi pre27 g
boundary condition: false
type: Species
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
is: HMDB00175
has only substance units: false
initial amount: NaN
is: C00130
initial concentration: 1.0
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 27
is: SBO:0000247
constant: false

metaR r2506
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110008#
is described by: ECO:0000000
name: Utilized transport
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110008#
reversible: true
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_29cf4821_4742_405c_aa15_c3ffc9dd2146
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:8503
boundary condition: true
is: Q92569
initial amount: NaN
name: PIK3R3
has only substance units: false
constant: false

metaR NDPK10
name: nucleoside-diphosphate kinase (ATP:dIDP)
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is described by: ECO:0000134
reversible: true
is: SBO:0000176
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
product: MODEL1310110008#
fast: false
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction

metaM ksi deg21 l
is: CHEBI:12936
name: keratan sulfate I, degradation product 21
is: HMDB00143
constant: false
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C132H213N9O114S6 CHARGE: -6

metaR HIStN1
kinetic law: MODEL1310110008#
name: Histidine transport (Na, H coupled)
type: Reaction
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is: SBO:0000185
product: MODEL1310110008#

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaR PROt2r
fast: false
name: L-proline reversible transport via proton symport
is: SBO:0000185
product: MODEL1310110008#
type: Reaction
reversible: true
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
modifier: MODEL1310110008#

metaR ILEt5m
is described by: ECO:0000000
is: SBO:0000185
name: Isoleucine mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
product: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110008#

metaM ahdt e
type: Species
constant: false
notes: FORMULA: C9H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C9H16N5O13P3/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-25-29(21,22)27-30(23,24)26-28(18,19)20/h4,6,15-16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,10,11,13,14,17)/p-4/t4-,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01367 EHMN_ABBREVIATION: C04895
name: 7,8-dihydroneopterin 3'-triphosphate(4-)
initial concentration: 1.0
is: CHEBI:58462
initial amount: NaN
boundary condition: false
is: HMDB00980
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_d0a7c917_b299_49a5_9c98_64f42cebe1e3
has only substance units: false
boundary condition: true
type: Species
name: LOXL2
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4017
is: Q9Y4K0

metaR SBTR
reversible: false
kinetic law: MODEL1310110008#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.21
modifier: MODEL1310110008#
product: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
reactant: MODEL1310110008#
is described by: ECO:0000269
name: D-sorbitol reductase
is version of: http://identifiers.org/ec-code/1.1.1.2

metaM 17ahprgnlone r
has only substance units: false
initial concentration: 1.0
is: CHEBI:28750
type: Species
is: HMDB00363
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
name: 17alpha-hydroxypregnenolone
notes: FORMULA: C21H32O3 CHARGE: 0 INCHI: InChI=1S/C21H32O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h4,15-18,23-24H,5-12H2,1-3H3/t15-,16+,17-,18-,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C05138

metaM cdp c
is: C00112
type: Species
initial concentration: 1.0
name: CDP
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: CHEBI:58069
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB01546
initial amount: NaN
constant: false

metaR AMACR2p
product: MODEL1310110008#
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/5.1.99.4
notes: GENE_ASSOCIATION: (23600.1) or (23600.2) SUBSYSTEM: Bile acid synthesis EC Number: 5.1.99.4 Confidence Level: 2 AUTHORS: NOTES:should be analogous to AMACRp as per KEGG - in this case: reductase not a racemase NJ
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#
name: alpha-methylacyl-CoA racemase (reductase)
is described by: ECO:0000304

metaR OAGD3te
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
name: oagd3 hs transport
product: MODEL1310110008#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
reversible: true
is: SBO:0000185
type: Reaction

metaM HC02207 e
name: prostaglandin-c2
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:27555
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
constant: false

metaR r2507
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
kinetic law: MODEL1310110008#
reversible: true
reactant: MODEL1310110008#
name: Utilized transport
is: SBO:0000185
fast: false
product: MODEL1310110008#
is described by: ECO:0000000

metaM q10 c
is: HMDB01072
name: ubiquinone-10
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: CHEBI:46245
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378

http://identifiers.org/biomodels.db/MODEL1310110008#_222ade5b_909f_4a23_97ed_0703c8302c00
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:8659
is: SBO:0000252
type: Species
constant: false
name: ALDH4A1

metaR NACHEX20ly
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
fast: false
product: MODEL1310110008#
reactant: MODEL1310110008#
modifier: MODEL1310110008#

metaM HC01401 m
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
has only substance units: false
type: Species
constant: false
is: CHEBI:27668
is: SBO:0000247
name: (S)-3-Hydroxydodecanoyl-CoA

metaR PI4PP
name: phosphatidylinositol-4-phosphate 4-phosphatase
reactant: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2425833 NOTES:NCD
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000

metaR DOLPMT4 Ler
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
product: MODEL1310110008#
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#

metaR FOAXC122C101x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)x
type: Reaction

metaM leuktrB4 c
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:57461
name: leukotriene B4(1-)
boundary condition: false
is: HMDB01085
constant: false

metaR SPRMS
fast: false
reactant: MODEL1310110008#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.5.1.22
reversible: false
name: spermine synthase
notes: GENE_ASSOCIATION: (6611.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.22 Confidence Level: 4 AUTHORS: PMID:7546290 NOTES:NCD
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000176
modifier: MODEL1310110008#
type: Reaction

metaR EX hpdca LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptadecanoate exchange
type: Reaction

metaR r0178
is: SBO:0000176
reactant: MODEL1310110008#
reversible: true
is version of: http://identifiers.org/ec-code/2.5.1.21
kinetic law: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
is described by: ECO:0000000
fast: false
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
modifier: MODEL1310110008#

metaR ASNNm
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (80150.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES:PMID: 11984834 (denotes it as potentially mitochondrial) mm
is: SBO:0000176
name: L-asparaginase (mitochondrial)
reactant: MODEL1310110008#
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.5.1.1
modifier: MODEL1310110008#
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110008#_03a05e63_57ba_493d_9ecf_e0e1ca6054d3
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:AA177072
constant: false
initial concentration: NaN
boundary condition: true
name: _AA177072_1_x
type: Species

metaR r0753
reversible: true
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000000
reactant: MODEL1310110008#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
fast: false

metaM mmcoa S m
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
initial amount: NaN
is: CHEBI:57327
is: HMDB02310
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
name: (S)-methylmalonyl-CoA(5-)

metaR EX c51crn
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

metaM biocyt c
type: Species
boundary condition: false
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/7886
is: C05552
initial amount: NaN
is: HMDB03134
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: SBO:0000247
initial concentration: 1.0
name: Biocytin

http://identifiers.org/biomodels.db/MODEL1310110008#_c8193cf6_553d_4e79_8d86_91dd714e573b
type: Species
is encoded by: hsa:3157
has only substance units: false
is: SBO:0000252
is: Q01581
name: HMGCS1
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN

metaR UREAt
kinetic law: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: (6523.1) or (6563.1) or (6528.1) or (8170.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:12856182,PMID:2490366,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:JLR
modifier: MODEL1310110008#
name: Urea transport via facilitate diffusion
type: Reaction
is described by: ECO:0000269
fast: false
product: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000185

metaR C142OHc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradeca dienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_c3289820_97a7_4c15_bc84_480c407ed223
name: DCK
is encoded by: hsa:1633
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: P27707

metaR EX 3thexddcoacrn
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy trans7,10-hexadecadienoyl carnitine
type: Reaction

metaM ca2 c
is: CHEBI:29108
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
initial concentration: 1.0
is: HMDB00464
name: calcium(2+)

http://identifiers.org/biomodels.db/MODEL1310110008#_892b1494_07ea_49cc_9430_ca0f92bd2ba3
is encoded by: hsa:7001
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
name: PRDX2
initial amount: NaN
initial concentration: NaN
type: Species

metaM HC02214 c
initial amount: NaN
constant: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
has only substance units: false
boundary condition: false
is: CHEBI:28852
name: prostaglandin-f1alpha
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR r0752
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is described by: ECO:0000000
reactant: MODEL1310110008#
is: SBO:0000176
modifier: MODEL1310110008#
type: Reaction
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110008#_a352136f_9223_46d8_9646_b13d8e86763e
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1544
is: P05177
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
name: CYP1A2
boundary condition: true

metaR r1997
type: Reaction
product: MODEL1310110008#
is: SBO:0000185
modifier: MODEL1310110008#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110008#_a11126ae_991e_4f94_98b1_1493cadeced3
name: PCBD1
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:5092
type: Species
initial amount: NaN
is: P61457
initial concentration: NaN
constant: false

metaR r0179
reversible: true
fast: false
is: SBO:0000176
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
kinetic law: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.27
is described by: ECO:0000000
modifier: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:

metaR FAS120COA
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
reactant: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction
name: fatty-acyl-CoA synthase (n-C12:0CoA)
fast: false
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_42f0a4d6_89d2_47e5_8bbb_522f43562c57
is: Q86XP1
name: DGKH
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:160851
constant: false

metaM ctdecdcoa m
is: HMDB00792
name: cis2trans4decadienoylcoa
type: Species
is: C08277
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
constant: false

metaM hs deg5 l
boundary condition: false
is: CHEBI:17895
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
is: HMDB00158
is: SBO:0000247
name: heparan sulfate, degradation product 5
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
initial amount: NaN

metaR CYTK2n
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110008#
is described by: ECO:0000269
name: cytidylate kinase (dCMP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is: SBO:0000176
fast: false
type: Reaction
reversible: true

metaR BDHm
is: SBO:0000176
is described by: ECO:0000269
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
reversible: true
type: Reaction
modifier: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.30

metaM dump c
is: C00365
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB01409
initial amount: NaN
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
name: dUMP
has only substance units: false
is: CHEBI:246422
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_50cd5f16_0029_4e95_a11d_66efb412e887
is: Q0VAA5
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:257068
name: PLCXD2
constant: false
is: SBO:0000252

metaM gal l
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
name: D-galactose
is: CHEBI:12936
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
initial amount: NaN
is: HMDB00143

metaM sgalside hs c
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB00187
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
boundary condition: false
name: sulfatide galactocerebroside
is: CHEBI:17115
constant: false
is: SBO:0000247

metaR r0385
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
is: SBO:0000176
fast: false
product: MODEL1310110008#
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:

metaM dctp c
name: dCTP
is: SBO:0000247
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: C00458
is: HMDB00998
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:16311

http://identifiers.org/biomodels.db/MODEL1310110008#_0b8d39e4_1fd9_4338_8803_d08aa4254781
name: ALDH9A1
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:223
is: P49189
initial concentration: NaN

metaR AG13T13g
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110008#
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110008#
reactant: MODEL1310110008#

metaM ksi pre6 g
is: CHEBI:58053
has only substance units: false
initial amount: NaN
type: Species
name: keratan sulfate I biosynthesis, precursor 6
notes: FORMULA: C107H174N7O80SX CHARGE: -2
is: SBO:0000247
boundary condition: false
is: HMDB00175
is: C00130
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_a18f77af_7837_4843_9269_a46fd408c758
is encoded by: hsa:9091
name: PIGQ
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is: B2RAU6
initial amount: NaN
constant: false

metaR ADPACTD
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport into cytosol (diffusion)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_32d08190_faad_4bd6_aec7_4fa9a5ca0de1
boundary condition: true
initial concentration: NaN
name: ATP5J2
is: Q6IBB3
is: SBO:0000252
constant: false
is encoded by: hsa:9551
initial amount: NaN
type: Species
has only substance units: false

metaM gd3 hs g
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: GD3
initial amount: NaN
type: Species
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
constant: false
is: CHEBI:28424
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_3d35ecd8_d2d9_49a6_834f_914aaa8d1cd7
is encoded by: hsa:226
name: ALDOA
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: P04075
constant: false
initial amount: NaN
boundary condition: true
type: Species

metaR r0750
reactant: MODEL1310110008#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:

metaR r0384
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
fast: false
is described by: ECO:0000000
reactant: MODEL1310110008#
type: Reaction
reversible: false
kinetic law: MODEL1310110008#
is: SBO:0000176
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110008#_b9d5dd2b_405d_4055_935b_0dc3e432522f
initial concentration: NaN
boundary condition: true
name: SOD1
is: P00441
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:6647
is: SBO:0000252
has only substance units: false

metaR FAOXC201C181x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

metaM hxcoa c
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: Hexanoyl-CoA (n-C6:0CoA)
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
initial concentration: 1.0
is: HMDB13130
boundary condition: false
is: SBO:0000247

metaM HC02214 e
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
name: prostaglandin-f1alpha
constant: false
initial amount: NaN
is: CHEBI:28852

metaR ACCOALm
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.17 Confidence Level: 2 AUTHORS: PMID:11150295 NOTES:TDV-mitochondrial version JLR- also acts on propanoate AMF- made reaction to create AMP not ADP and changed EC
name: acetate-CoA ligase (AMP-forming)
product: MODEL1310110008#
modifier: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
reversible: false
type: Reaction
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/6.2.1.1
is described by: ECO:0000304
is: SBO:0000176

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaR 4NPHSULT
reactant: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
kinetic law: MODEL1310110008#
reversible: false
fast: false
name: 4-Nitrophenol Sulfotransferase
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.8.2.1
type: Reaction
is described by: ECO:0000269

metaM ca2 e
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
name: calcium(2+)
is: HMDB00464
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:29108
initial concentration: 1.0

metaR 4HBZCOAFm
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
kinetic law: MODEL1310110008#
type: Reaction
name: 4-hydroxybenzoyl-CoA formation
is described by: ECO:0000000
product: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110008#_a1dd85af_2af3_4ca9_9353_7943798f1690
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:4711
initial concentration: NaN
type: Species
is: O43674
is: SBO:0000252
boundary condition: true
name: NDUFB5

metaR NACHEX12ly
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110008#
product: MODEL1310110008#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110008#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110008#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_86ae624d_5825_401d_b75c_a6b6e0074528
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:3421
name: IDH3G
initial amount: NaN
is: P51553
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_05bc5711_c7b8_4684_9b4a_8b696a0b0d9c
has only substance units: false
type: Species
is encoded by: hsa:285973
initial concentration: NaN
is: Q674R7
boundary condition: true
initial amount: NaN
name: ATG9B
constant: false
is: SBO:0000252

metaR DOPAt4 2 r
reactant: MODEL1310110008#
is described by: ECO:0000269
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
name: Dopamine reversible transport in via sodium symport (1:2)
modifier: MODEL1310110008#
type: Reaction

metaM trp L c
has only substance units: false
is: HMDB00929
is: SBO:0000247
boundary condition: false
is: CHEBI:16828
type: Species
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
initial amount: NaN
constant: false
name: L-tryptophan
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_b043e4c8_572e_4fbc_8a81_c40148992785
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: PIGL
is encoded by: hsa:9487
boundary condition: true
type: Species
is: Q9Y2B2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_92cd7fe9_d55f_4217_8b9d_5d01542c3011
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: E7EPT3
is encoded by: hsa:501
name: ALDH7A1
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaR PPBNGS
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (210.1) or (210.2) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.24 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
type: Reaction
name: porphobilinogen synthase
fast: false
is described by: ECO:0000269
reversible: false
product: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/4.2.1.24
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_49e6bf38_8af8_4220_af89_aa10f3be867c
is: P80365
type: Species
name: HSD11B2
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3291

metaM ksii core2 deg3 l
type: Species
is: HMDB00143
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:12936
is: SBO:0000247
constant: false
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 3

http://identifiers.org/biomodels.db/MODEL1310110008#_6ecf8b62_fe3a_4817_8836_1b9fa08d06c1
name: PLCG2
is encoded by: hsa:5336
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: P16885
initial concentration: NaN

metaR RNDR1
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110008#
is described by: ECO:0000254
name: ribonucleoside-diphosphate reductase (ADP)
type: Reaction
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
modifier: MODEL1310110008#

metaR UMPK
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
fast: false
product: MODEL1310110008#
modifier: MODEL1310110008#
reversible: true
is: SBO:0000176
name: UMP kinase
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110008#_a7e488f2_f62d_431b_9750_8d71dc9da008
is: Q16762
name: TST
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:7263
type: Species
initial concentration: NaN
initial amount: NaN

metaM HC00250 e
is: SBO:0000247
initial amount: NaN
is: CHEBI:29919
initial concentration: 1.0
boundary condition: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
constant: false
has only substance units: false
name: hydrosulfide
type: Species

metaM hmgcoa m
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB01375
constant: false
type: Species
name: Hydroxymethylglutaryl-CoA
boundary condition: false
is: CHEBI:15467
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356

metaR SPMS
notes: GENE_ASSOCIATION: (6723.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.16 Confidence Level: 4 AUTHORS: PMID:2069720,PMID:8343131 NOTES:
product: MODEL1310110008#
fast: false
reversible: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#
name: spermidine synthase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.5.1.16
is: SBO:0000176

metaR FACOAL140i
name: fatty-acid--CoA ligase (tetradecanoate)
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
modifier: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_37b02f4a_a492_4e30_a582_e5eb670d75b9
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is: P51648
name: ALDH3A2
boundary condition: true
is encoded by: hsa:224

http://identifiers.org/biomodels.db/MODEL1310110008#_cb9a433e_01cc_43ad_b007_e830840802a5
constant: false
boundary condition: true
is encoded by: hsa:26503
is: SBO:0000252
is: Q9NRA2
name: SLC17A5
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false

metaM trp L e
name: L-tryptophan
initial concentration: 1.0
is: HMDB00929
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:16828
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080

metaR RNDR2
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: false
fast: false
type: Reaction
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
name: ribonucleoside-diphosphate reductase (GDP)
is described by: ECO:0000254
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000176

metaM prgnlone m
is: HMDB00253
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
name: pregnenolone
is: CHEBI:16581
is: SBO:0000247

metaM dec47dicoa m
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: 4,7-decadienoylcoa
type: Species
is: http://identifiers.org/pubchem.compound/16019966
constant: false

metaM ksi pre9 g
is: HMDB00175
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58053
type: Species
is: C00130
name: keratan sulfate I biosynthesis, precursor 9
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_8c2bbfed_3098_4077_88c2_6b1e45eee2bf
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:226
has only substance units: false
name: ALDOA
is: SBO:0000252

metaM 2hexdtricoa m
is: HMDB02288
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: 2,7,10-hexadecatrienoylcoa
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_6bd6a873_bec7_4133_81dd_47705e4bb404
name: HK1
is: B3KXY9
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3098
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_8ce7fd6b_a1bc_4bfd_80b6_2e384204d4b1
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: _AV717590_1_c
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AV717590

metaR FAOXC164GC163m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

metaR r0389
is described by: ECO:0000000
kinetic law: MODEL1310110008#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110008#
name: Pyridoxine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.1.3.12
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.1.3.12 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
reversible: true
fast: false

metaR r0755
reactant: MODEL1310110008#
fast: false
modifier: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
is: SBO:0000176
type: Reaction
reversible: true
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
kinetic law: MODEL1310110008#

metaM sgalside hs g
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
has only substance units: false
name: sulfatide galactocerebroside
constant: false
type: Species
is: HMDB00061
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58343

metaR GALU
name: UTP-glucose-1-phosphate uridylyltransferase
product: MODEL1310110008#
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is: SBO:0000176
reactant: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.9
reversible: true

metaR HMGCOASim
reversible: false
reactant: MODEL1310110008#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.3.10
product: MODEL1310110008#
kinetic law: MODEL1310110008#
name: Hydroxymethylglutaryl CoA synthase (ir)
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
modifier: MODEL1310110008#
type: Reaction
fast: false
is: SBO:0000176

metaM pail34p hs c
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
initial amount: NaN
is: CHEBI:57658
type: Species
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_209bab5b_b77f_4396_9d07_1a58bd2c648a
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
name: _AA532636_1_m
is encoded by: hsa:AA532636
boundary condition: true
initial amount: NaN

metaM 2docopencoa m
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
has only substance units: false
name: 2,7,10,13,16-docosapentenoylcoa
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_55e42cb7_ce3b_41f7_9bb4_60b167dbc14e
initial amount: NaN
name: CYP1B1
is encoded by: hsa:1545
has only substance units: false
is: Q16678
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
boundary condition: true

metaM dlnlcgcoa m
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: dihomo-gamma-linolenyl coenzyme A
is: CHEBI:27979
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102

metaR S6TASE18ly
modifier: MODEL1310110008#
reactant: MODEL1310110008#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110008#
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
product: MODEL1310110008#
fast: false

metaM HC00250 c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:29919
initial amount: NaN
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
has only substance units: false
name: hydrosulfide
constant: false
type: Species

metaM mi134p c
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:58414
is: HMDB01143
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_cebb5e7a_19b2_4be5_bf85_8bd7512d2d47
constant: false
is encoded by: hsa:AA419122
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: _AA419122_1_c
is: SBO:0000252

metaM 3pg m
is: SBO:0000247
boundary condition: false
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
initial amount: NaN
is: HMDB00807
type: Species
constant: false
is: CHEBI:58272
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_167e2352_5a4a_4d50_815e_13389288b00d
has only substance units: false
name: _AI090874_1_c
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI090874
is: SBO:0000252
boundary condition: true

metaM pcrn m
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/107738
has only substance units: false
name: propionyl-carnitine
initial concentration: 1.0
is: HMDB00824
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3

metaR r0388
product: MODEL1310110008#
name: Pyridoxamine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.4.3.5
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110008#
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:

metaR MCLACCYSR
kinetic law: MODEL1310110008#
product: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
name: 3-mercaptolactate:cysteine reductase
reversible: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

metaR EX 3ivcrn
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-isovaleryl carnitine
type: Reaction

metaR r0754
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
fast: false
product: MODEL1310110008#
is described by: ECO:0000000
modifier: MODEL1310110008#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reactant: MODEL1310110008#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true

metaM 3hmbcoa m
is: SBO:0000247
has only substance units: false
constant: false
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
is: HMDB01356
boundary condition: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
initial concentration: 1.0
type: Species
is: CHEBI:57312
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_dc020145_18b9_4107_b8d6_52b7102a962f
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: SLC6A10P
is encoded by: hsa:386757

metaM ksi deg33 l
type: Species
is: HMDB00143
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
name: keratan sulfate I, degradation product 33
boundary condition: false
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
initial concentration: 1.0
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110008#_d4ba0ae1_4c94_4233_8cbd_086b9dfff14b
initial concentration: NaN
constant: false
boundary condition: true
name: INPP1
is: SBO:0000252
is encoded by: hsa:3628
has only substance units: false
type: Species
is: P49441
initial amount: NaN

metaR MGCHrm
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
is version of: http://identifiers.org/ec-code/4.2.1.18
fast: false
modifier: MODEL1310110008#
reversible: true
type: Reaction
reactant: MODEL1310110008#
is described by: ECO:0000269
product: MODEL1310110008#
kinetic law: MODEL1310110008#
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110008#_fc4fd716_4114_4c57_b60a_1edabbd117b1
name: TPK1
type: Species
constant: false
is encoded by: hsa:27010
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: F5GZG6
is: SBO:0000252

metaM dump m
name: dUMP(2-)
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
constant: false
is: SBO:0000247
is: HMDB01409
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:246422
type: Species
initial concentration: 1.0

metaR GluForTx
name: Glutamate formimidoyltransferase
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
fast: false
reactant: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000176
modifier: MODEL1310110008#
reversible: false
kinetic law: MODEL1310110008#
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.5
is described by: ECO:0000269

metaR CHSTEROLtrc
name: transport of cholesterol into the cytosol
is: SBO:0000185
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000134
reactant: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
reversible: true
fast: false

metaM dlnlcgcoa r
has only substance units: false
initial amount: NaN
is: CHEBI:27979
name: dihomo-gamma-linolenyl coenzyme A
boundary condition: false
initial concentration: 1.0
is: C03595
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102

metaR MM7Cbg
modifier: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
reactant: MODEL1310110008#
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110008#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.113
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
product: MODEL1310110008#

metaR H2Otly
type: Reaction
kinetic law: MODEL1310110008#
reversible: true
fast: false
name: H2O transport, lysosomal
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110008#
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_3d8f8c42_d414_4166_a3f0_a6895c8c2ce0
name: MYO5B
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4645
boundary condition: true
type: Species
is: Q9H6Y6

metaM 4izp c
name: 4-Imidazolone-5-propanoate
type: Species
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB01014
initial amount: NaN
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
is: CHEBI:57255
boundary condition: false
initial concentration: 1.0

metaM hyptaur e
is: SBO:0000247
constant: false
is: CHEBI:16668
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00965
initial amount: NaN
name: Hypotaurine
boundary condition: false
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5)

http://identifiers.org/biomodels.db/MODEL1310110008#_f63bd1cd_c5a4_4a2e_88ab_8d0efa7bb481
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:759
is: P00915
name: CA1
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR IDOURte
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
name: L-iduronate transport, extracellular
product: MODEL1310110008#
fast: false
is described by: ECO:0000134
reactant: MODEL1310110008#

metaR CYSGLYexR
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
name: L-cysteine/glycine reversible exchanger
product: MODEL1310110008#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110008#
reversible: true
reactant: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110008#_b2877250_1594_4d56_bd58_8fa3c57ad271
is: SBO:0000297
is encoded by: hsa:4967
initial amount: NaN
initial concentration: NaN
has part: B4E3E9
boundary condition: true
name: DLD:DLST:OGDH:PDHX
constant: false
has only substance units: false
type: Species

metaR URIt5le
is: SBO:0000185
reactant: MODEL1310110008#
reversible: false
name: uridine transport in via sodium symport (1:2)
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
modifier: MODEL1310110008#
fast: false
is described by: ECO:0000134
product: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_83469955_1552_4aff_8ba3_4c9654382c98
initial amount: NaN
has only substance units: false
name: ITPKA
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is: P23677
is encoded by: hsa:3706
type: Species

metaR GALT
is: SBO:0000176
reactant: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
fast: false
modifier: MODEL1310110008#
is described by: ECO:0000000
name: galactose-1-phosphate uridylyltransferase
reversible: true
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.7.12

http://identifiers.org/biomodels.db/MODEL1310110008#_c0555f8f_5293_49c7_8f52_17ff69cb2d9a
initial concentration: NaN
name: CYP19A1
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:1588
is: P11511

metaR EX thym LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymine exchange
type: Reaction

metaR r1487
kinetic law: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
is described by: ECO:0000000
name: EC:6.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000176
product: MODEL1310110008#
type: Reaction
reversible: true

metaM prgnlone c
constant: false
name: pregnenolone
is: HMDB00253
is: CHEBI:16581
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953
initial concentration: 1.0

metaM gdpmann c
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
boundary condition: false
is: CHEBI:57527
type: Species
name: GDP-alpha-D-mannose(2-)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB01163
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_bf841218_0447_4300_8c46_2c089b828dfd
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is: F5H2Y9
is encoded by: hsa:8854
name: ALDH1A2
is: SBO:0000252
initial amount: NaN
type: Species

metaM gal e
is: C00124
boundary condition: false
is: CHEBI:0
initial concentration: 1.0
initial amount: NaN
name: D-Galactose
constant: false
is: HMDB00143
notes: FORMULA: C6H12O6 CHARGE: 0
type: Species
has only substance units: false
is: SBO:0000247

metaR r0647
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
fast: false
name: Spontaneous reaction
is described by: ECO:0000000
product: MODEL1310110008#
reversible: true
is: SBO:0000176
reactant: MODEL1310110008#
type: Reaction

metaR RE3626M
is: SBO:0000176
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: false
product: MODEL1310110008#
name: RE3626
reactant: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
fast: false
is described by: ECO:0000000

metaM dodecanac x
is: HMDB00623
type: Species
name: Dodecanedioic acid
has only substance units: false
notes: FORMULA: C12H20O4 CHARGE: -2
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaM ksii core4 l
type: Species
boundary condition: false
is: HMDB01644
has only substance units: false
name: keratan sulfate II (core 4-linked)
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
is: SBO:0000247
is: CHEBI:17140

metaM dctp n
boundary condition: false
has only substance units: false
is: CHEBI:16311
initial concentration: 1.0
name: dCTP
is: C00458
initial amount: NaN
constant: false
is: HMDB00998
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
type: Species
is: SBO:0000247

metaM dudp n
is: CHEBI:60471
has only substance units: false
initial concentration: 1.0
type: Species
name: dUDP(3-)
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: HMDB01000
initial amount: NaN

metaR TMNDNCCRNt
type: Reaction
modifier: MODEL1310110008#
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110008#
reactant: MODEL1310110008#
name: transport into the mitochondria (carnitine)
fast: false
reversible: false
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_ee1d4610_7d76_4ac0_ba75_a83b0b24ade9
initial concentration: NaN
is: Q49AT3
has only substance units: false
name: B3GALNT1
boundary condition: true
type: Species
is encoded by: hsa:8706
initial amount: NaN
is: SBO:0000252
constant: false

metaR r2110
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110008#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110008#_1029f7c3_656f_4985_9c96_f81feedabba5
is: P49915
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:8833
name: GMPS

http://identifiers.org/biomodels.db/MODEL1310110008#_293114b3_a54a_4436_a246_65a3bd06369d
type: Species
has only substance units: false
name: _T83654_1_m
initial concentration: NaN
is encoded by: hsa:T83654
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM glx c
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00119
has only substance units: false
name: glyoxylate
is: CHEBI:36655

metaM phytcoa x
constant: false
name: phytanoyl-CoA(4-)
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57391
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
is: HMDB01359
boundary condition: false

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaR GALt4
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
product: MODEL1310110008#
type: Reaction
fast: false
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110008#
reversible: true
name: galactose transport via sodium symport
modifier: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_1a7e80bb_d045_421a_890f_28dc13f5d280
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:10587
is: SBO:0000252
name: TXNRD2
boundary condition: true
has only substance units: false
type: Species
is: Q9NNW7

metaM so4 c
name: sulfate
has only substance units: false
type: Species
is: CHEBI:16189
initial amount: NaN
is: SBO:0000247
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
boundary condition: false
is: HMDB01448
constant: false

metaM CE5101 m
boundary condition: false
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
type: Species
initial concentration: 1.0
is: CHEBI:57795
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_775af516_39c6_499e_8799_c221594a6149
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: SI
boundary condition: true
is encoded by: hsa:6476
constant: false
has only substance units: false
is: P14410

metaR r2111
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110008#
fast: false
is: SBO:0000185
reactant: MODEL1310110008#
is described by: ECO:0000000
reversible: true

metaR 5HOXINDACTO2OX
is: SBO:0000176
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.3.1 Confidence Level: 2 AUTHORS: PMID:11306106 NOTES:SAB questionable--balanced, but h2o2 production is based on an obscure comment in entrez
name: 5-Hydroxyindoleacetaldehyde:oxygen oxidoreductase
modifier: MODEL1310110008#
reversible: false
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.2.3.1
fast: false
reactant: MODEL1310110008#

metaR r0497
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.4.2
is: SBO:0000176
reactant: MODEL1310110008#
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
fast: false
reversible: true
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
product: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110008#_174be770_60eb_4f03_b464_3d3209a332b6
is: O14734
name: ACOT8
type: Species
is encoded by: hsa:10005
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaM ksii core4 pre9 g
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
name: keratan sulfate II biosynthesis, precursor 9
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:28067
has only substance units: false
initial amount: NaN

metaM sgalside hs l
is: CHEBI:16349
name: sulfatide galactocerebroside
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
has only substance units: false
is: HMDB00904
is: SBO:0000247

metaM gal c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C00124
is: CHEBI:0
initial amount: NaN
name: D-Galactose
notes: FORMULA: C6H12O6 CHARGE: 0
has only substance units: false
constant: false
type: Species
is: HMDB00143

metaR r0758
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:8155713,PMID:8605195 NOTES:
is: SBO:0000176
reversible: true
type: Reaction
fast: false
name: 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase Tryptophan metabolism EC:1.2.1.3
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.5.4.16

http://identifiers.org/biomodels.db/MODEL1310110008#_da327a66_c83d_48dd_a98c_1a8980cd9d57
name: SLC35B2
type: Species
is: Q8TB61
boundary condition: true
initial amount: NaN
is encoded by: hsa:347734
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_d4e5ea1b_edcb_4c99_88e3_d9842944b421
type: Species
name: LDHA
constant: false
is encoded by: hsa:3939
initial concentration: NaN
is: P00338
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_c976000c_b458_4278_b8fe_4f80a754ec87
is encoded by: hsa:83549
constant: false
type: Species
boundary condition: true
initial amount: NaN
name: UCK1
is: Q5JT09
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

metaR FAOXC163C143m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_e6f28655_e23c_4d22_8d22_a1e3645c12f0
is: Q9HAB8
is: SBO:0000252
name: PPCS
initial amount: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:79717

metaR LYStm
name: Lysine mitochondrial transport via ornithine carrier
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110008#
fast: false
reversible: true
kinetic law: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_cb20cf54_8841_486f_b68b_f635d4e72d3b
is: SBO:0000252
boundary condition: true
name: PDE9A
is encoded by: hsa:5152
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
type: Species

metaM hmgcoa c
boundary condition: false
is: HMDB01375
has only substance units: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial amount: NaN
name: Hydroxymethylglutaryl-CoA
is: CHEBI:15467
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_5b92c5bd_c086_4e1b_9573_08e1d6f1e581
is: P07195
has only substance units: false
is encoded by: hsa:3945
type: Species
name: LDHB
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM hs deg4 l
is: SBO:0000247
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
has only substance units: false
constant: false
name: heparan sulfate, degradation product 4
initial amount: NaN
is: CHEBI:16126
initial concentration: 1.0
type: Species
boundary condition: false

metaR SEBACIDTD
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacic acid into cytosol (diffusion)
type: Reaction

metaR r0644
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_8064b064_8ffb_48a1_9ff6_d7f7a193e8f4
initial amount: NaN
name: ATP5G3
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:518
constant: false
type: Species

metaM C05280 m
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
boundary condition: false
has only substance units: false
is: HMDB03952
is: CHEBI:28002
initial concentration: 1.0
initial amount: NaN
name: cis,cis-3,6-Dodecadienoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110008#_0bf8feb8_8744_4267_8d5b_fc30db9ed09d
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is: Q06055
is encoded by: hsa:517
initial concentration: NaN
name: ATP5G2
initial amount: NaN
has only substance units: false

metaM decdicrn e
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C17H29NO4 CHARGE: 0
name: decadienoyl carnitine
type: Species
constant: false
boundary condition: false
is: HMDB13325

metaM Lcystin e
initial concentration: 1.0
is: CHEBI:16283
type: Species
name: L-cystine
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
boundary condition: false
is: HMDB00192
constant: false

metaR C162OHc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxy hexadecadienoyl carnitine
type: Reaction

metaR DCYTt
reversible: true
fast: false
name: deoxycytidine transport via diffusion
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
product: MODEL1310110008#

metaM tetpent6coa x
name: tetracosapentaenoyl coenzyme A, n-6
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
initial concentration: 1.0
initial amount: NaN
is: C16172
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_a413ad1b_ac15_4a09_9bcd_85e0fd02290e
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:10905
boundary condition: true
name: MAN1A2
is: O60476
constant: false
initial amount: NaN
initial concentration: NaN

metaR LYStn
name: L-lysine transport, nuclear
is: SBO:0000185
kinetic law: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
type: Reaction
product: MODEL1310110008#
fast: false
reactant: MODEL1310110008#

metaR LSTO1r
is version of: http://identifiers.org/ec-code/1.14.21.6
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
type: Reaction
fast: false
reactant: MODEL1310110008#
modifier: MODEL1310110008#
name: Lathosterol oxidase
reversible: false
kinetic law: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110008#

metaM tetde5coa x
boundary condition: false
is: SBO:0000247
name: 5-tetradecenoylcoa
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB13109
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
constant: false

metaR G14T9g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
reactant: MODEL1310110008#
reversible: false
product: MODEL1310110008#
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110008#_474dcb77_c98f_437d_8f9b_49821f9fb7cb
is: Q9H0P0
initial concentration: NaN
name: NT5C3
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:51251
constant: false
has only substance units: false
boundary condition: true

metaR r0643
fast: false
reversible: true
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
is: SBO:0000176
type: Reaction

metaR RE1845X
product: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
name: RE1845
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000176
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
kinetic law: MODEL1310110008#

metaM 1pyr5c m
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:15893
constant: false
is: HMDB01301
is: C03912
name: 1-Pyrroline-5-carboxylate

metaR CRNt
type: Reaction
kinetic law: MODEL1310110008#
is: SBO:0000185
name: L-carnitine reversible transport
reversible: true
fast: false
reactant: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110008#

metaM adrncrn m
notes: FORMULA: C29H49NO4 CHARGE: 0
is: SBO:0000247
boundary condition: false
is: HMDB00062
is: CHEBI:16347
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
name: Adrenyl carnitine
is: C00318

http://identifiers.org/biomodels.db/MODEL1310110008#_73d90999_3ce2_41d3_bd1c_0d832e1e37aa
boundary condition: true
type: Species
initial amount: NaN
constant: false
name: SLC34A2
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10568
is: O95436

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaM decdicrn c
is: HMDB13325
initial concentration: 1.0
initial amount: NaN
name: decadienoyl carnitine
notes: FORMULA: C17H29NO4 CHARGE: 0
is: SBO:0000247
type: Species
constant: false
boundary condition: false
has only substance units: false

metaR LCADi
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
is described by: ECO:0000304
fast: false
product: MODEL1310110008#
is: SBO:0000176
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110008#
name: lactaldehyde dehydrogenase
reversible: false
modifier: MODEL1310110008#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.36

metaM Lcystin c
boundary condition: false
is: CHEBI:16283
is: SBO:0000247
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
name: L-cystine
has only substance units: false
constant: false
is: HMDB00192
initial amount: NaN
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_763fc15b_410c_4705_8b7e_b20a2916c6bb
is: Q38G75
name: GALE
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:2582
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR RE1533M
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1533
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000176
modifier: MODEL1310110008#
fast: false
reversible: true
product: MODEL1310110008#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR r0642
fast: false
reactant: MODEL1310110008#
is described by: ECO:0000000
reversible: true
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
product: MODEL1310110008#

metaR ACACT10m
product: MODEL1310110008#
is described by: ECO:0000134
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
name: acetyl-CoA C-acetyltransferase, mitochondrial
is: SBO:0000176
reactant: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.9
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency

metaM 3pg c
is: C00197
name: 3-Phospho-D-glycerate
is: HMDB00807
initial concentration: 1.0
is: CHEBI:58272
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/3497

metaR C162OHe
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C16:2OH
type: Reaction

metaM 4ppcys c
is: C04352
is: CHEBI:59458
type: Species
constant: false
initial amount: NaN
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
is: SBO:0000247
is: HMDB01117
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352

metaR r0494
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110008#
reversible: true
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
kinetic law: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

metaM gpi sig r
is: CHEBI:58190
boundary condition: false
initial amount: NaN
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
is: HMDB00224
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: Y CHARGE: 0
is: SBO:0000247

metaM tethex3coa x
name: tetracosahexaenoyl coenzyme A
is: HMDB06243
is: C16168
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205478
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM dudp m
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: CHEBI:60471
name: dUDP(3-)
is: HMDB01000
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
boundary condition: false

metaM hyptaur c
initial concentration: 1.0
name: Hypotaurine
type: Species
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
is: HMDB00965
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:16668
constant: false
boundary condition: false

metaM f6p c
initial amount: NaN
name: D-Fructose 6-phosphate
boundary condition: false
is: C00085
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/3385
is: HMDB00124
is: CHEBI:57579
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR LNLNCACRNt
kinetic law: MODEL1310110008#
is: SBO:0000185
reactant: MODEL1310110008#
fast: false
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
product: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#
reversible: false

metaM methf m
boundary condition: false
type: Species
initial amount: NaN
constant: false
name: (6R)-5,10-methenyltetrahydrofolate
is: SBO:0000247
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: CHEBI:57455
initial concentration: 1.0
has only substance units: false
is: HMDB01354

metaR r0641
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.4
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
modifier: MODEL1310110008#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110008#_736b3933_d753_4da2_91e3_8006c4e5053b
has only substance units: false
name: AOC2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:314
initial amount: NaN
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_b7226767_402a_4ebc_98ef_e78bf53f91fa
initial amount: NaN
initial concentration: NaN
is: P48448
is encoded by: hsa:222
is: SBO:0000252
type: Species
constant: false
has only substance units: false
name: ALDH3B2
boundary condition: true

metaM HC01459 x
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA
is: CHEBI:27458
has only substance units: false

metaR PHETHPTOX2
reversible: false
modifier: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395
is: SBO:0000176
reactant: MODEL1310110008#
is described by: ECO:0000269
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
fast: false
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.14.16.1

metaM idour c
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
boundary condition: false
type: Species
is: HMDB02704
constant: false
is: CHEBI:21338
initial amount: NaN
is: SBO:0000247
name: L-iduronate
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_b0719d99_62fe_4b11_9a9b_7f3bb3c56518
has only substance units: false
is encoded by: hsa:84693
boundary condition: true
type: Species
is: Q96PE7
name: MCEE
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false

metaR ALAGLNexR
kinetic law: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
reactant: MODEL1310110008#
name: L-alanine/glutamine reversible exchange
fast: false
is: SBO:0000185
modifier: MODEL1310110008#
type: Reaction
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_1d8be725_5b37_49ce_8878_5b45e2e7e273
initial concentration: NaN
is encoded by: hsa:377841
name: ENTPD8
constant: false
has only substance units: false
type: Species
is: Q5MY95
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR FAOXC226m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_a3c58c40_975b_45c2_bb25_a31cae716902
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
name: B3GALT5
is encoded by: hsa:10317
initial amount: NaN
type: Species
initial concentration: NaN

metaM cspg a e
constant: false
is: CHEBI:16040
boundary condition: false
type: Species
has only substance units: false
is: HMDB00630
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
initial concentration: 1.0
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
initial amount: NaN

metaM tridcoa m
name: tridecanoylcoa
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C34H56N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0
is: HMDB13109
has only substance units: false
boundary condition: false

metaR r1552
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110008#
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_dc0236ce_ae91_43f4_a98b_2387035abf6e
has only substance units: false
constant: false
is encoded by: hsa:231
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: AKR1B1
is: P15121
initial amount: NaN

metaM chito2pdol U c
has only substance units: false
type: Species
is: CHEBI:12427
initial concentration: 1.0
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
notes: FORMULA: C1185H1940N20O170P20 CHARGE: -20
constant: false
is: SBO:0000247
boundary condition: false

metaM accoa x
type: Species
constant: false
has only substance units: false
is: SBO:0000247
name: Acetyl-CoA
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: CHEBI:57288
is: HMDB01206
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: C00024

http://identifiers.org/biomodels.db/MODEL1310110008#_9c0e13e2_1c2a_4b8d_b1f5_8a2339d323ec
is encoded by: hsa:6546
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
is: F6VPY9
initial amount: NaN
name: SLC8A1
type: Species
boundary condition: true

metaR r2105
reversible: true
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
product: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR DESAT18 4
is version of: http://identifiers.org/ec-code/1.14.19.1
is: SBO:0000176
modifier: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
product: MODEL1310110008#
reactant: MODEL1310110008#

metaR MM8Cg
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.113
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
is described by: ECO:0000000
reversible: false
type: Reaction
modifier: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110008#_42566bbb_1be4_46a8_82ae_10638f3896b0
is encoded by: hsa:8228
is: P41247
constant: false
type: Species
is: SBO:0000252
name: PNPLA4
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_658f9f43_83e6_4786_9364_b3bc71d180bb
is: O14735
constant: false
boundary condition: true
has only substance units: false
name: CDIPT
initial amount: NaN
is encoded by: hsa:10423
type: Species
is: SBO:0000252
initial concentration: NaN

metaM hexdectecoa x
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB02288
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
name: 2,4,7,10-hexadecatetraenoylcoa
constant: false
has only substance units: false
initial amount: NaN

metaR GALASE19ly
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
product: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.6.4
name: beta-galactosidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110008#
is described by: ECO:0000269

metaM glx m
is: CHEBI:36655
is: HMDB00119
initial amount: NaN
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
name: glyoxylate
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
constant: false

metaR r1492
is: SBO:0000185
reactant: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110008#
name: Utilized transport

metaR r1553
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110008#
is described by: ECO:0000000
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM apoC c
is: SBO:0000247
is: CHEBI:33190
initial amount: NaN
has only substance units: false
is: HMDB11111
constant: false
boundary condition: false
name: Apocarboxlase (no lys residue)
initial concentration: 1.0
type: Species
notes: FORMULA: XH CHARGE: 0

metaR r2104
is: SBO:0000185
product: MODEL1310110008#
reactant: MODEL1310110008#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110008#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_a0b188c2_56ba_422f_ac76_67de7211f3eb
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: GBA
is: P04062
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:2629

metaR GALASE9ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
product: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4

http://identifiers.org/biomodels.db/MODEL1310110008#_884abeac_d794_4d96_83dc_71e8b6a9a2ed
initial amount: NaN
is encoded by: hsa:4645
is: Q9H6Y6
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
name: MYO5B
is: SBO:0000252
type: Species

metaM 2hexdtricoa x
initial amount: NaN
initial concentration: 1.0
name: 2,7,10-hexadecatrienoylcoa
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
constant: false
type: Species
is: HMDB02288
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR HMGCOARc
is described by: ECO:0000134
fast: false
product: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
is version of: http://identifiers.org/ec-code/1.1.1.34
is: SBO:0000176
reversible: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#

metaM fadh2 c
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
initial concentration: 1.0
name: FADH2(2-)
is: CHEBI:58307
constant: false
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB01197
initial amount: NaN

metaM so4 l
boundary condition: false
initial amount: NaN
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false
is: SBO:0000247
is: CHEBI:16189
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB01448
name: sulfate

metaR S6TASE10ly
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: galactose-6-sulfate sulfatase, lysosomal
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: true
modifier: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5

metaM mi1p D c
is: SBO:0000247
name: 1D-myo-inositol 1-phosphate(2-)
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: HMDB02985
is: CHEBI:58433

metaR r2107
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110008#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
product: MODEL1310110008#
type: Reaction

metaR r1554
kinetic law: MODEL1310110008#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110008#_0cab8887_9233_45d6_a07f_82adb15aa58b
type: Species
name: ACOT7
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: O00154
is encoded by: hsa:11332

http://identifiers.org/biomodels.db/MODEL1310110008#_f4a59804_5a3b_4826_aa7b_902ca1cfc03a
boundary condition: true
has only substance units: false
is encoded by: hsa:8574
initial concentration: NaN
initial amount: NaN
is: O43488
constant: false
type: Species
is: SBO:0000252
name: AKR7A2

metaR RBFK
modifier: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110008#
is described by: ECO:0000269
kinetic law: MODEL1310110008#
type: Reaction
name: riboflavin kinase
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.1.26
is: SBO:0000176

metaM lanost r
boundary condition: false
is: SBO:0000247
is: HMDB01251
initial concentration: 1.0
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
name: lanosterol
type: Species
is: CHEBI:16521
initial amount: NaN
has only substance units: false
constant: false

metaR r2106
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
reversible: true
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

metaR FAOXC143C123m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

metaM prpp c
has only substance units: false
type: Species
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00280
name: 5-Phospho-alpha-D-ribose 1-diphosphate
is: C00119
is: CHEBI:58017
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_cecf8009_0185_4244_9443_4350a74996a9
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:124
is: P07327
constant: false
initial concentration: NaN
type: Species
name: ADH1A
initial amount: NaN

metaM xol7ah c
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
initial amount: NaN
type: Species
is: CHEBI:2290
is: SBO:0000247
name: 7alpha-hydroxy-5beta-cholestan-3-one
is: HMDB06892
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_7485d279_e101_4b91_a58b_85c6abf2be28
has only substance units: false
boundary condition: true
is: Q9UFY1
is encoded by: hsa:5335
is: SBO:0000252
name: PLCG1
constant: false
initial concentration: NaN
initial amount: NaN
type: Species

metaR C180CPT2
reactant: MODEL1310110008#
product: MODEL1310110008#
name: carnitine O-stearoyl transferase
reversible: false
modifier: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
kinetic law: MODEL1310110008#

metaR HPDCAt
reversible: true
name: fatty acid transport via diffusion
type: Reaction
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
product: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000185
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110008#_2d1cf3f8_7142_446b_864e_cff9974797c8
initial concentration: NaN
is encoded by: hsa:7371
name: UCK2
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is: Q9BZX2

metaR GULNDer
is: SBO:0000176
reversible: true
fast: false
name: gulonate dehydrogenase, endoplasmic reticulum
is described by: ECO:0000000
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.19 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
product: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction

metaR r1556
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110008#
reversible: true
product: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR HISSNAT5tc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR PI4PLC
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.4.11
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000176
name: phosphatidylinositol 4-phosphate phospholipase C
modifier: MODEL1310110008#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
reversible: false
type: Reaction

metaR r2101
kinetic law: MODEL1310110008#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
modifier: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM so4 e
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
boundary condition: false
is: SBO:0000247
name: sulfate
is: CHEBI:16189
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: HMDB01448
type: Species

metaR RE3001M
is: SBO:0000176
reactant: MODEL1310110008#
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.34
name: RE3001
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:

metaR C180CPT1
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (1375.4) or (1375.2) or (126129.1) or (1375.1) or (1374.1) or (1375.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TV (see C160CRN)
type: Reaction
modifier: MODEL1310110008#
name: production of stearoylcarnitine
is: SBO:0000176
reversible: false
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110008#_b42f095c_d170_4706_b6b1_37e3334f1235
boundary condition: true
initial concentration: NaN
name: SLC25A26
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:115286
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_e4fc33aa_08d1_453a_8667_12fa40576f07
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial concentration: NaN
name: CA9
is: Q16790
has only substance units: false
is encoded by: hsa:768
initial amount: NaN

metaM crtsl r
type: Species
is: HMDB00063
initial concentration: 1.0
is: CHEBI:17650
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C21H30O5 CHARGE: 0 INCHI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00735
constant: false
name: cortisol

metaR r1557
is described by: ECO:0000000
reactant: MODEL1310110008#
reversible: true
product: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110008#

metaM biocyt n
is: http://identifiers.org/pubchem.compound/7886
name: Biocytin
initial concentration: 1.0
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: HMDB03134
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: C05552
boundary condition: false

metaM prpp e
initial amount: NaN
is: CHEBI:58017
type: Species
initial concentration: 1.0
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
constant: false
has only substance units: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
boundary condition: false
is: SBO:0000247
is: HMDB00280

metaR C30CPT1
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of propionylcarnitine
type: Reaction

metaR r2100
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
is described by: ECO:0000000

metaR FTHFL
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
product: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.5
reversible: true
name: Formate-tetrahydrofolate ligase

metaR AHCYSte
product: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110008#
is: SBO:0000185
fast: false
name: Transport of S-adenosyl-L-homocysteine
is described by: ECO:0000134
kinetic law: MODEL1310110008#

metaR ACGPID
kinetic law: MODEL1310110008#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
modifier: MODEL1310110008#
reversible: false
name: N-acetylglucosaminylphosphatidylinositol deacetylase
is version of: http://identifiers.org/ec-code/3.5.1.89

metaM hxcoa x
name: Hexanoyl-CoA (n-C6:0CoA)
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00705
constant: false
initial concentration: 1.0

metaR NCKt
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
fast: false
is described by: ECO:0000269
type: Reaction
name: Na+/Ca2+-K+ exchange
product: MODEL1310110008#
reactant: MODEL1310110008#
reversible: true
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110008#_6d758d4f_0e24_4afc_8ec4_c91639ade048
boundary condition: true
name: SLC4A5
is: SBO:0000252
is encoded by: hsa:57835
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false

metaR INSTt4
modifier: MODEL1310110008#
reactant: MODEL1310110008#
reversible: true
product: MODEL1310110008#
type: Reaction
name: inositol transport via sodium symport
kinetic law: MODEL1310110008#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110008#_add84b5f_224b_4172_98e1_3c8c755f8638
is: O43272
constant: false
is: SBO:0000252
is encoded by: hsa:5625
name: PRODH
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_4a526fe2_fc26_43c4_b6dc_e6903c939d7a
is: SBO:0000252
is encoded by: hsa:79611
is: Q9H6R3
name: ACSS3
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_d62a9762_e065_4442_8edf_32419cd7952d
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:6520
boundary condition: true
is: P08195
initial amount: NaN
name: SLC3A2

http://identifiers.org/biomodels.db/MODEL1310110008#_8333722a_e276_4b4c_894e_51501c4ed2d3
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1807
is: Q14117
initial concentration: NaN
constant: false
name: DPYS

metaM biocyt m
initial concentration: 1.0
is: HMDB03134
is: http://identifiers.org/pubchem.compound/7886
type: Species
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
constant: false
boundary condition: false
has only substance units: false
is: C05552
initial amount: NaN
name: Biocytin
is: SBO:0000247

metaR FAOXC102C103x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_091b47db_0983_41f0_93b7_6db957cf4feb
has only substance units: false
is: Q9NPB1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
name: NT5M
boundary condition: true
is encoded by: hsa:56953

metaR AHCYStd
type: Reaction
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
name: diffusion of S-Adenosyl-L-homocysteine
fast: false
is: SBO:0000185

metaR PPA
type: Reaction
modifier: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000269
reversible: false
name: inorganic diphosphatase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.1
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
kinetic law: MODEL1310110008#
fast: false
product: MODEL1310110008#

metaR r2103
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110008#
fast: false
reversible: true
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110008#
is: SBO:0000185
modifier: MODEL1310110008#

metaR OCD11CRNCPT2
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaM 2docohexecoa m
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
initial amount: NaN
name: 2,7,10,13,16,19-docosahexenoylcoa
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_4daeb0a2_0a20_4bd7_8d3e_daddc3500c17
type: Species
constant: false
is: SBO:0000252
name: TK2
initial amount: NaN
boundary condition: true
has only substance units: false
is: O00142
is encoded by: hsa:7084
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_b7f30886_4d9c_4377_8d27_740f7da294bc
initial concentration: NaN
name: DPM3:DPM1:DPM2
has part: Q9P2X0
type: Species
constant: false
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:54344
boundary condition: true
has only substance units: false
is encoded by: hsa:8818

metaR SIAT4Bg
is: SBO:0000176
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.99.4
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
product: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
is described by: ECO:0000269
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
reactant: MODEL1310110008#
reversible: false
type: Reaction

metaR r1559
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110008#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000000

metaM gthrd m
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
name: glutathionate(1-)
initial concentration: 1.0
is: HMDB00125
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: CHEBI:57925
has only substance units: false
constant: false

metaM HC01401 x
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
initial amount: NaN
type: Species
is: CHEBI:27668
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: (S)-3-Hydroxydodecanoyl-CoA

metaM acetol c
has only substance units: false
name: hydroxyacetone
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:27957
is: HMDB06961
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_12f9c98b_70df_40a0_bcbb_bac990ac3749
initial amount: NaN
is encoded by: hsa:8654
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
type: Species
has only substance units: false
name: PDE5A

metaM phytcoa c
type: Species
initial amount: NaN
is: CHEBI:57391
name: phytanoyl-CoA(4-)
constant: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
boundary condition: false
is: HMDB01359
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR r2102
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: true
reactant: MODEL1310110008#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110008#
fast: false

metaR UDPG4E
name: UDPglucose 4-epimerase
is version of: http://identifiers.org/ec-code/5.1.3.2
fast: false
reversible: true
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
type: Reaction
product: MODEL1310110008#
is: SBO:0000176
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110008#_0bf33628_25b0_480d_b8e5_7499ec175727
initial amount: NaN
is encoded by: hsa:10201
has only substance units: false
is: SBO:0000252
name: NME6
initial concentration: NaN
constant: false
is: O75414
boundary condition: true
type: Species

metaR C4tmc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine into mitochondrial matrix
type: Reaction

metaM dnad c
is: HMDB01179
is: SBO:0000247
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: C00857
initial amount: NaN
is: CHEBI:18304
constant: false
name: Deamino-NAD+

http://identifiers.org/biomodels.db/MODEL1310110008#_ca636e14_7742_45cc_881d_45daf14dbcdf
is: P53602
is: SBO:0000252
is encoded by: hsa:4597
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
name: MVD
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_c3ad3a2b_33ad_4161_8cb9_9c0b4035b410
constant: false
type: Species
boundary condition: true
is: Q9GZV3
name: SLC5A7
is: SBO:0000252
is encoded by: hsa:60482
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM clpn hs c
notes: FORMULA: CHARGE: 0
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: CHEBI:21338
is: SBO:0000247
name: clpn_hs[c]
is: HMDB02704

http://identifiers.org/biomodels.db/MODEL1310110008#_2317c1b6_d03c_47e1_a83f_3aacd99e12fd
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is: Q96I99
constant: false
boundary condition: true
name: SUCLG2
is encoded by: hsa:8801
initial concentration: NaN

metaR ACOAD10m
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
product: MODEL1310110008#
modifier: MODEL1310110008#
is: SBO:0000176
type: Reaction

metaM dgchol c
is: HMDB00637
constant: false
has only substance units: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: glycochenodeoxycholate
is: CHEBI:36252
initial concentration: 1.0
type: Species

metaR EX c3dc
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for malonyl carnitine
type: Reaction

metaR VLCSr
is: SBO:0000176
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
fast: false
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: Very-long-chain-fatty-acid-CoA ligase
product: MODEL1310110008#
type: Reaction
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110008#
reactant: MODEL1310110008#

metaR DMNONCRNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
product: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110008#
reversible: true
kinetic law: MODEL1310110008#
name: 4,8 dimethylnonanoyl carnitine transport (mitochondria)

metaR RE0456M
is described by: ECO:0000000
reactant: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6997299,PMID:8483833 NOTES:
kinetic law: MODEL1310110008#
reversible: true
is: SBO:0000176
product: MODEL1310110008#
type: Reaction
name: RE0456

metaR 4HOXPACDOX NADP
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
type: Reaction
reversible: true
product: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
is: SBO:0000176
kinetic law: MODEL1310110008#
is described by: ECO:0000304
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase

metaM tetpent6coa c
has only substance units: false
boundary condition: false
is: C16172
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
initial amount: NaN
initial concentration: 1.0
name: tetracosapentaenoyl coenzyme A, n-6

metaR DIGALSIDEtg
name: digalside hs intracellular transport
type: Reaction
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false

metaR CH25H
is described by: ECO:0000269
reactant: MODEL1310110008#
reversible: false
type: Reaction
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.14.99.38
fast: false
modifier: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000176
name: cholesterol 25-hydroxylase
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaM urcan c
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
initial concentration: 1.0
is: CHEBI:17771
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: C00785
constant: false
is: HMDB00301
boundary condition: false
type: Species
name: Urocanate

metaR LTD4DP
product: MODEL1310110008#
name: Leukotriene D4 dipeptidase
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110008#_0c702ff0_c87f_40d8_a3d3_a8268640d0c5
initial amount: NaN
name: COX8C
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:341947
type: Species
is: Q7Z4L0
has only substance units: false

metaM gthox e
type: Species
has only substance units: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: CHEBI:58297
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB03337
boundary condition: false
is: SBO:0000247

metaM cyan e
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
initial amount: NaN
initial concentration: 1.0
name: hydrogen cyanide
is: HMDB02084
is: CHEBI:18407
has only substance units: false
boundary condition: false

metaR DURAD2
product: MODEL1310110008#
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
name: dihydrothymin dehydrogenase (NADP)
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
is version of: http://identifiers.org/ec-code/1.3.1.2
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110008#
reversible: true
is described by: ECO:0000269

metaR r0181
is described by: ECO:0000000
reactant: MODEL1310110008#
fast: false
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
kinetic law: MODEL1310110008#
reversible: true
modifier: MODEL1310110008#

metaR AMETtd
reactant: MODEL1310110008#
name: diffusion of S-Adenosyl-L-methionine
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000134
product: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR LEUKTRF4t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
fast: false
reactant: MODEL1310110008#
name: leukotriene F4 transport
product: MODEL1310110008#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110008#
is described by: ECO:0000000

metaR ACOAD1fm
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
type: Reaction
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
is: SBO:0000176
modifier: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110008#

MODEL1310110008#
species: metaM mmcoa S m
species: metaM bildglcur r
species: metaM Ssq23epx r
species: metaM lneldccoa c
species: metaM fmn c
species: metaM gluside hs c
species: metaM idp c
species: metaM pmtcoa r
species: metaM 4nph c
species: metaM tridcoa m
species: metaM dudp c
species: metaM dmnoncoa c
species: metaM ocdcea e
species: metaM sphmyln hs c
species: metaM 3octpencoa m
species: metaM bilglcur c
species: metaM dcsptn1crn c
species: metaM xoltriol c
species: metaM hexdiac c
stoichiometry: 0.036117
stoichiometry: 2.0
species: metaM so4 e
species: metaM cspg b l
species: metaM ala D c
species: metaM HC01610 e
species: metaM urate c
species: metaM 2docopencoa x
species: metaM lnlncacrn c
species: metaM 3thexddcoa m
species: metaM c10crn e
species: metaM coucoa m
species: metaM trp L e
species: metaM succ x
species: metaM mercplaccys c
species: metaM dcdp c
species: metaM estradiol r
species: metaM hexe3coa x
species: metaM 2obut c
species: metaM HC02206 e
species: metaM ksii core2 deg5 l
species: metaM ksii core4 pre1 g
species: metaM gal l
species: metaM ksii core2 g
species: metaM akg x
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
species: metaM s2l2n2m2mn l
species: metaM 3octdece1crn c
species: metaM udpglcur r
species: metaM gullac c
species: metaM CE5854 e
species: metaM ksi deg21 l
species: metaM pmtcoa m
species: metaM dchac e
species: metaM tdec4ecoa m
species: metaM hom L e
species: metaM adrncoa c
species: metaM mgacpail hs r
value: 0.0
species: metaM docohexcoa m
species: metaM CE2432 m
species: metaM xol27oh r
species: metaM nadh c
species: metaM 4mptnl e
species: metaM glyc R c
species: metaM ocdececrn m
species: metaM docoscoa x
species: metaM dag hs r
species: metaM 3hmp m
species: metaM coa c
species: metaM xol7ah c
species: metaM ksi pre21 g
species: metaM 4nphsf e
species: metaM ksi deg41 l
species: metaM decdicrn e
species: metaM c8crn e
species: metaM 2maacoa m
species: metaM nrpphr c
species: metaM sebacid x
species: metaM pi l
species: metaM fmn e

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaM adrncrn c
has only substance units: false
name: Adrenyl carnitine
is: CHEBI:16347
is: HMDB00062
type: Species
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C29H49NO4 CHARGE: 0
is: SBO:0000247
is: C00318

http://identifiers.org/biomodels.db/MODEL1310110008#_b5347160_d976_4833_8068_ef2fb11cbd5b
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:AI935189
has only substance units: false
initial amount: NaN
boundary condition: true
name: _AI935189_1_m
is: SBO:0000252

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaM apoC m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:32551
name: Apocarboxlase (no lys residue)
type: Species
constant: false
initial amount: NaN
is: HMDB00182
notes: FORMULA: XH CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110008#_c304df32_1cae_4162_898f_ee0404a6b37c
is encoded by: hsa:5139
initial concentration: NaN
name: PDE3A
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
is: Q14432
boundary condition: true

metaR NTD2m
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (56953.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.3.5
fast: false
name: 5'-nucleotidase (UMP), mitochondrial
modifier: MODEL1310110008#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110008#
is: SBO:0000176
type: Reaction

metaM 4hexdtricoa m
type: Species
is: HMDB02288
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
name: 4,7,10-hexadecatrienoylcoa

metaM Ser Gly Ala X Gly l
has only substance units: false
notes: FORMULA: XH CHARGE: 0
is: HMDB02183
boundary condition: false
type: Species
is: CHEBI:36005
name: protein-linked serine residue (glycosaminoglycan attachment site)
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_24741dee_edfd_4e89_bb21_3bbb8784692b
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
name: _H77542_1_r
is encoded by: hsa:H77542
boundary condition: true

metaM strch2 e
boundary condition: false
initial amount: NaN
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
is: CHEBI:4167
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C18H32O16 CHARGE: 0
has only substance units: false
initial concentration: 1.0
is: HMDB00122

metaM hexdectecoa m
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: false
is: HMDB02288
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: SBO:0000247
name: 2,4,7,10-hexadecatetraenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110008#_c31b7f5a_d26b_44ce_bf8b_63eede4389c6
is: SBO:0000252
initial amount: NaN
type: Species
is: Q6IBC4
is encoded by: hsa:4726
has only substance units: false
boundary condition: true
name: NDUFS6
constant: false
initial concentration: NaN

metaM gthox c
is: HMDB03337
is: C00127
name: Oxidized glutathione
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:58297
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127

metaM cyan c
has only substance units: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
boundary condition: false
name: hydrogen cyanide
initial concentration: 1.0
type: Species
is: HMDB02084
initial amount: NaN
is: CHEBI:18407
is: SBO:0000247
constant: false

metaM hexe3coa m
has only substance units: false
is: SBO:0000247
is: HMDB06522
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
initial concentration: 1.0
name: 3-hexenoylcoa
boundary condition: false
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_0b88b3d5_e022_4355_8f08_76a99324517c
constant: false
boundary condition: true
type: Species
name: DGKQ
has only substance units: false
is encoded by: hsa:1609
initial amount: NaN
is: P52824
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110008#_db168088_a76a_43eb_9095_f775723c50fe
initial amount: NaN
name: RRM2
initial concentration: NaN
is encoded by: hsa:6241
boundary condition: true
type: Species
constant: false
is: P31350
is: SBO:0000252
has only substance units: false

metaM dsmsterol r
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB02719
initial amount: NaN
is: CHEBI:17737
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
constant: false
name: desmosterol

metaR PE HSter
product: MODEL1310110008#
is described by: ECO:0000000
reversible: true
name: phosphatidylethanolamine scramblase
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110008#_7b51c1ee_54f9_455c_8b62_0cf6db5cffb1
constant: false
is encoded by: hsa:3141
initial concentration: NaN
is: P50747
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: HLCS
type: Species

metaR r2109
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110008#
kinetic law: MODEL1310110008#

metaR HIBDm
is described by: ECO:0000269
kinetic law: MODEL1310110008#
reversible: true
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.31
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
is: SBO:0000176
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
modifier: MODEL1310110008#
reactant: MODEL1310110008#

metaR CYTK13n
reactant: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dATP),nuclear
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction
is described by: ECO:0000269
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_53490273_0ba1_47e9_b87f_5820e87ec72b
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:6487
is: SBO:0000252
type: Species
initial concentration: NaN
name: ST3GAL3
has only substance units: false

metaR GALASE15ly
fast: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
name: beta-galactosidase, lysosomal
modifier: MODEL1310110008#
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110008#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_acf8bb56_4d8c_4863_97b2_57a454c1366b
initial amount: NaN
is: P06744
is encoded by: hsa:2821
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: GPI
constant: false
boundary condition: true

metaM 4h2oglt m
initial concentration: 1.0
type: Species
is: CHEBI:17742
is: SBO:0000247
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
constant: false
initial amount: NaN
boundary condition: false
is: HMDB02070
name: 4-hydroxy-2-oxoglutarate(2-)
has only substance units: false

metaR DNDPt9m
kinetic law: MODEL1310110008#
name: dADP transport via dTDP antiport
reversible: false
modifier: MODEL1310110008#
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110008#

metaR r1993
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000
modifier: MODEL1310110008#
fast: false
reversible: false

metaM xu5p D c
constant: false
name: D-xylulose 5-phosphate(2-)
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00868
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
type: Species
boundary condition: false
is: CHEBI:57737

metaR ADPT
is described by: ECO:0000269
fast: false
product: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (353.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.7 Confidence Level: 4 AUTHORS: PMID:14674717,PMID:15196008 NOTES:
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.2.7
kinetic law: MODEL1310110008#
name: adenine phosphoribosyltransferase
is: SBO:0000176
type: Reaction
reversible: false

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR r2108
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110008#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110008#
reversible: true

metaR CYSTGLUex
reversible: false
is: SBO:0000185
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (23657.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
fast: false
name: L-cystine/L-glutamate exchanger
kinetic law: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
is described by: ECO:0000269
reactant: MODEL1310110008#

metaR FAOXC185C164m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

metaR S6T16g
reversible: false
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110008#
is: SBO:0000176

metaM HC02208 c
initial amount: NaN
name: prostaglandin-d1
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
type: Species
has only substance units: false
constant: false
is: CHEBI:27696
is: SBO:0000247

metaM so4 m
is: HMDB01448
boundary condition: false
constant: false
is: CHEBI:16189
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
initial amount: NaN
name: sulfate

metaM progly c
type: Species
notes: FORMULA: C7H12N2O3 CHARGE: 0
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB11178
name: L-Prolinylglycine
initial amount: NaN
constant: false

metaR r1992
is: SBO:0000185
reactant: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
reversible: false
product: MODEL1310110008#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000

metaR r0186
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110008#
is: SBO:0000176
reactant: MODEL1310110008#
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
modifier: MODEL1310110008#

metaM prostgh2 c
type: Species
is: HMDB01381
constant: false
is: CHEBI:57405
has only substance units: false
name: prostaglandin H2(1-)
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial concentration: 1.0

metaM accoa m
initial amount: NaN
constant: false
is: CHEBI:57288
name: Acetyl-CoA
is: SBO:0000247
is: C00024
is: HMDB01206
has only substance units: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial concentration: 1.0
boundary condition: false
type: Species

metaR ALAGLYexR
type: Reaction
is: SBO:0000185
reactant: MODEL1310110008#
reversible: true
modifier: MODEL1310110008#
fast: false
product: MODEL1310110008#
kinetic law: MODEL1310110008#
name: L-alanine/glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304

metaR CYTK3n
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
product: MODEL1310110008#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,CTP),nuclear
modifier: MODEL1310110008#

metaR r0390
is: SBO:0000176
reversible: true
reactant: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
type: Reaction
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_7dbbe3e0_d0e1_48f8_ac31_c15e6e2b6cd0
initial concentration: NaN
is: SBO:0000252
is: Q92521
is encoded by: hsa:9488
constant: false
name: PIGB
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN

metaM hxcoa m
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
has only substance units: false
name: Hexanoyl-CoA (n-C6:0CoA)
is: SBO:0000247
is: HMDB06522
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
initial amount: NaN

metaR EX glyphe LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylphenylalaine
type: Reaction

metaR DESAT18 6
reversible: false
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
name: fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
is described by: ECO:0000269

metaM glx x
is: CHEBI:36655
name: glyoxylate
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: HMDB00119
type: Species
constant: false
initial amount: NaN

metaR FADtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
name: FAD transporter, peroxisomal
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#

metaR THBPT4ACAMDASE
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
modifier: MODEL1310110008#
reversible: false
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.96
product: MODEL1310110008#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction

metaR S3TASE3ly
product: MODEL1310110008#
name: N-acetylglucosamine-3-sulfatase, lysosomal
is: SBO:0000176
fast: false
kinetic law: MODEL1310110008#
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD

metaM hs deg10 l
initial concentration: 1.0
type: Species
name: heparan sulfate, degradation product 10
has only substance units: false
is: HMDB00127
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:15748

metaM accoa n
is: HMDB01206
name: acetyl-CoA(4-)
is: CHEBI:57288
initial amount: NaN
has only substance units: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_3eb9d103_2689_441d_8fef_e3d58d55e976
type: Species
has only substance units: false
name: SLC35A1
is encoded by: hsa:10559
is: P78382
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_eb0e41d1_7536_4078_95f7_d7296b993944
initial concentration: NaN
boundary condition: true
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:U37519
has only substance units: false
is: SBO:0000252
name: _U37519_1_c

metaM cspg a l
initial amount: NaN
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
is: SBO:0000247
constant: false
is: CHEBI:36005
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB02183
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_7275da91_049d_41e2_bea1_7ef4878a5bc5
constant: false
initial concentration: NaN
name: _AU149534_1_m
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:AU149534
is: SBO:0000252
type: Species

metaM gthrd c
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00125
type: Species
name: Reduced glutathione
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: CHEBI:57925
initial concentration: 1.0
is: C00051

http://identifiers.org/biomodels.db/MODEL1310110008#_e47e264d_6379_4df4_bfcc_1da97e0ce810
is: Q8WYR1
initial concentration: NaN
boundary condition: true
is encoded by: hsa:23533
is: SBO:0000252
constant: false
has only substance units: false
name: PIK3R5
type: Species
initial amount: NaN

metaM dgchol e
is: HMDB00637
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: glycochenodeoxycholate
is: SBO:0000247
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: CHEBI:36252
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_9c892f7a_4fba_4f3a_ad04_17f3c75a1501
constant: false
is encoded by: hsa:8883
boundary condition: true
is: A8MU28
type: Species
is: SBO:0000252
name: NAE1
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM ksi pre17 g
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
is: CHEBI:28067
is: SBO:0000247
has only substance units: false
type: Species
name: keratan sulfate I biosynthesis, precursor 17

metaR ALASm
fast: false
modifier: MODEL1310110008#
is described by: ECO:0000254
reversible: false
reactant: MODEL1310110008#
name: 5-aminolevulinate synthase
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
is: SBO:0000176
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.3.1.29
is version of: http://identifiers.org/ec-code/2.3.1.37
type: Reaction

metaM glygn5 e
notes: FORMULA: C12H21O11X CHARGE: 0
boundary condition: false
is: HMDB06372
initial concentration: 1.0
name: glycogen, structure 5 (glycogenin-2[1,4-Glc])
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: CHEBI:33871
is: SBO:0000247

metaM ksi pre10 g
constant: false
type: Species
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
is: C00130
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 10
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58053
is: HMDB00175

metaR EX ksi deg1 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I, degradation product 1 exchange
type: Reaction

metaR GALASE6ly
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110008#
name: beta-galactosidase, lysosomal
is: SBO:0000176
reactant: MODEL1310110008#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction

metaR SIAASE3ly
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
modifier: MODEL1310110008#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110008#
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110008#
reversible: false
fast: false

metaR r1994
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000000
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110008#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR LINKDEG1ly
name: degradation of proteoglycan linkage region, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
product: MODEL1310110008#
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction

metaR sink decdicoa LPAREN c RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Sink for 2,6-dodecadienoylcoa(c)
type: Reaction

metaM CE2421 m
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:30623
type: Species
is: SBO:0000247
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
name: (3S)-3-hydroxylinoleoyl-CoA
is: HMDB02329

metaR r1551
is described by: ECO:0000000
fast: false
product: MODEL1310110008#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110008#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_d4842b24_607c_4221_b102_467d6d59b343
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9197
is: O00400
constant: false
initial amount: NaN
name: SLC33A1

metaM progly e
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: HMDB11178
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: L-Prolinylglycine
notes: FORMULA: C7H12N2O3 CHARGE: 0

metaM cholcoaone x
constant: false
boundary condition: false
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:58507
is: HMDB06891
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
initial concentration: 1.0

metaM gthrd e
constant: false
name: glutathionate(1-)
is: HMDB00125
has only substance units: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57925

metaR r0393
is: SBO:0000176
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
product: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
reversible: false
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.74
modifier: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_67cc5a7a_25d5_4ab3_8ad4_a0600b7c97ff
initial amount: NaN
boundary condition: true
is encoded by: hsa:1716
has only substance units: false
name: DGUOK
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_fee8ff20_b6c8_4546_a5e5_3c0e2eba058c
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:197257
name: LDHD
is: Q86WU2
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN

metaM HC02208 e
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
name: prostaglandin-d1
initial concentration: 1.0
is: CHEBI:27696
type: Species
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1

metaR ADA
is version of: http://identifiers.org/ec-code/3.5.4.4
modifier: MODEL1310110008#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
name: Adenosine deaminase
kinetic law: MODEL1310110008#
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_7cd445e1_f4d6_49d1_9451_ac3222f6f37c
name: PDE1A
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
is: P54750
is encoded by: hsa:5136
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_bca90122_e22e_4d06_bb61_f18ae2e5161e
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:518
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_b88d94c9_18ea_4afd_8eb7_0451b0538065
initial concentration: NaN
is encoded by: hsa:1956
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is: P00533
name: EGFR
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_a9d05aeb_5cb7_458d_81d9_ca54abd2e8ee
initial amount: NaN
has only substance units: false
boundary condition: true
name: SLC8A3
is: SBO:0000252
is encoded by: hsa:6547
initial concentration: NaN
constant: false
type: Species

metaR r0308
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
reactant: MODEL1310110008#
fast: false
is described by: ECO:0000000
reversible: false
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
product: MODEL1310110008#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_46fd16e2_d958_4129_923d_659664053ada
has only substance units: false
is encoded by: hsa:760
constant: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
name: CA2
is: P00918

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR C14STRr
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.3.1.70
fast: false
name: C-14 sterol reductase
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
reactant: MODEL1310110008#
is: SBO:0000176
kinetic law: MODEL1310110008#
reversible: false
product: MODEL1310110008#

metaM co2 x
boundary condition: false
type: Species
name: carbon dioxide
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:16526
is: SBO:0000247
is: HMDB01967
initial concentration: 1.0

metaR FAOXC12DCc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: formation of dodecanedioyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_e73c54ec_6398_4975_98ac_6f91fce6c1d0
boundary condition: true
is encoded by: hsa:3290
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: HSD11B1
is: SBO:0000252
constant: false
type: Species

metaR AKGDm
kinetic law: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/1.2.4.2
modifier: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4
notes: GENE_ASSOCIATION: (4967.2) and (1738.1 and 8050.1) and (1743.1) or (4967.1) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Citric acid cycle EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:1542694 NOTES:EC taken from Ligand TV. Genetic
product: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.3.1.61
is described by: ECO:0000134
name: 2-oxoglutarate dehydrogenase
reversible: false

metaR G14T8g
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110008#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
kinetic law: MODEL1310110008#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
is: SBO:0000176

metaM prostgh2 e
boundary condition: false
is: HMDB01381
name: prostaglandin H2(1-)
initial concentration: 1.0
has only substance units: false
is: CHEBI:57405
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: SBO:0000247
type: Species
initial amount: NaN

metaR CHOLATEt
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
is: SBO:0000185
name: cholate transport via bicarbonate countertransport
type: Reaction
reactant: MODEL1310110008#
modifier: MODEL1310110008#
reversible: true

metaR CSNt
reactant: MODEL1310110008#
is: SBO:0000185
product: MODEL1310110008#
type: Reaction
is described by: ECO:0000269
name: cytosine transport via facilated diffusion
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
reversible: true
fast: false

metaR FAOXC101C102m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_d1694cc2_5850_4d70_9208_3dbd56d475f7
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q5QPH3
type: Species
constant: false
name: ACSS2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:55902

metaR CORE2GTg
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
modifier: MODEL1310110008#
product: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.102
is: SBO:0000176
reactant: MODEL1310110008#
type: Reaction
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
reversible: false
kinetic law: MODEL1310110008#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110008#_9ce25d19_0121_4264_91fc_1608b17c9835
is: SBO:0000252
constant: false
type: Species
name: PNPO
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:55163
is: Q9NVS9
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_1eb491db_5ed7_45dc_b707_5b55042cc13f
constant: false
boundary condition: true
has only substance units: false
name: GALT
is encoded by: hsa:2592
initial concentration: NaN
is: SBO:0000252
is: B2RAT6
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_ce99f2fe_8bad_4c40_828a_2c8e801a948f
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: STARD3
boundary condition: true
type: Species
is: B4DUY1
constant: false
initial concentration: NaN
is encoded by: hsa:10948

metaR PPPGOm
kinetic law: MODEL1310110008#
name: protoporphyrinogen oxidase, mitochondrial
is version of: http://identifiers.org/ec-code/1.3.3.4
fast: false
product: MODEL1310110008#
reversible: false
reactant: MODEL1310110008#
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5498.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.4 Confidence Level: 2 AUTHORS: PMID:8771201 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110008#_85d8a824_b4f3_4aed_8696_66ee33210c1e
has only substance units: false
is encoded by: hsa:570
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q14032
initial amount: NaN
constant: false
name: BAAT
type: Species

metaR DIGALSIDEtl
reversible: true
type: Reaction
name: digalside hs intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
kinetic law: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#
is: SBO:0000185

metaM dcacoa m
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:61430
is: HMDB06404
name: Decanoyl-CoA (n-C10:0CoA)
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: C05274
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR HPYRR2x
reversible: false
type: Reaction
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (3948.1) or (197257.1) or (3945.1) or (160287.1) or (3945.1 and 3939.1) or (92483.1) or (3939.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:14635115,PMID:5635456 NOTES:NCD
name: hydroxypyruvate reductase (NADH)
is: SBO:0000176
product: MODEL1310110008#
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.27
is version of: http://identifiers.org/ec-code/1.1.2.4
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110008#_2843f75a_6e24_4e7e_b8c8_2ae8fa8520f4
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:3417
is: O75874
has only substance units: false
name: IDH1
initial concentration: NaN
boundary condition: true
constant: false

metaR IZPN
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110008#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110008#
name: Imidazolonepropionase
product: MODEL1310110008#
is: SBO:0000176

metaR SRTNt6 2 r
reactant: MODEL1310110008#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
reversible: true
modifier: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
kinetic law: MODEL1310110008#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110008#_fabcc851_e3a5_4ef4_b034_cccbc307c275
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6120
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q53TV9
type: Species
name: RPE

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_952188ba_9d5a_4a80_938f_d7ce303f3a55
initial concentration: NaN
is encoded by: hsa:522
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
name: ATP5J
type: Species
initial amount: NaN

metaR S2TASE3ly
modifier: MODEL1310110008#
reversible: false
kinetic law: MODEL1310110008#
product: MODEL1310110008#
fast: false
name: iduronate-2-sulfatase, lysosomal
reactant: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.13
is: SBO:0000176

metaR PPM
product: MODEL1310110008#
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.2.2
is: SBO:0000176
modifier: MODEL1310110008#
reversible: true
fast: false
is described by: ECO:0000000
name: phosphopentomutase
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (5236.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110008#_c2b493cb_c92e_41a8_ae6d_2100833b69be
type: Species
is encoded by: hsa:6888
name: TALDO1
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P37837
constant: false
is: SBO:0000252

metaR PAIL45P HStn
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_973a7f74_c8fe_4fd6_976d_b5360a9cbc27
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: ALAS1
is: Q5JAM2
is encoded by: hsa:211
type: Species

metaR r1117
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
name: Facilitated diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
reversible: true

metaR FAOXC163C164x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)x
type: Reaction

metaM 2dp6mobq m
boundary condition: false
is: CHEBI:50773
constant: false
name: 2-decaprenyl-6-methoxy-1,4-benzoquinone
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C57H86O3 CHARGE: 0 INCHI: InChI=1S/C57H86O3/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58)43-56(60-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+

http://identifiers.org/biomodels.db/MODEL1310110008#_8afb26c5_753d_4d28_b13b_8bb3052608d2
is: SBO:0000252
initial amount: NaN
is: Q8IXK2
type: Species
has only substance units: false
constant: false
is encoded by: hsa:79695
initial concentration: NaN
name: GALNT12
boundary condition: true

metaM HC01444 e
type: Species
initial concentration: 1.0
name: Galactosylglycerol
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
has only substance units: false
is: CHEBI:15754
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false

metaM mi4p D c
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:58469
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3-,4+,5-,6-/m0/s1
initial amount: NaN
type: Species
name: 1D-myo-inositol 4-phosphate(2-)
is: HMDB01313

metaR KSII CORE2tly
is described by: ECO:0000000
reversible: false
product: MODEL1310110008#
kinetic law: MODEL1310110008#
name: keratan sulfate II (core 2) transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110008#
fast: false
type: Reaction

metaM lnlncacoa m
name: alpha-Linolenoyl-CoA
is: HMDB06290
constant: false
is: CHEBI:51985
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
type: Species

metaR r1116
type: Reaction
reversible: true
fast: false
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
is described by: ECO:0000000
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000185

metaM thbpt4acam n
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: CHEBI:15374
type: Species
boundary condition: false
is: SBO:0000247
name: 4a-hydroxytetrahydrobiopterin
is: HMDB02281
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false

metaM gthox m
constant: false
is: CHEBI:58297
type: Species
is: HMDB03337
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaM cyan m
type: Species
name: hydrogen cyanide
constant: false
initial amount: NaN
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: HMDB02084
is: CHEBI:18407
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR S6TASE17ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110008#
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
product: MODEL1310110008#
reversible: true
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110008#

metaR HPDCACRNCPT2
is described by: ECO:0000000
name: heptadecanoate transport into the mitochondria
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
reactant: MODEL1310110008#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110008#
product: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.3.1.21

metaM ksi pre30 g
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00175
is: C00130
constant: false
has only substance units: false
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
is: CHEBI:58053
initial concentration: 1.0
type: Species
name: keratan sulfate I biosynthesis, precursor 30

metaR FAOXC164C143m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)m
type: Reaction

metaR CHSTEROLt2
fast: false
is described by: ECO:0000000
reactant: MODEL1310110008#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
name: cholesterol intracellular transport
product: MODEL1310110008#
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_f464f595_f562_40e5_b6ff_3efb903541bf
boundary condition: true
is: P49748
initial amount: NaN
has only substance units: false
name: ACADVL
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:37
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_c1a9ebcc_0470_493d_8911_ab4290367a34
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
name: SLC5A1
type: Species
constant: false
initial concentration: NaN
is: P13866
is encoded by: hsa:6523

metaM guln c
name: L-gulonate
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB03290
initial amount: NaN
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
boundary condition: false
is: CHEBI:13115
constant: false
is: SBO:0000247

metaR r0377
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000000
type: Reaction
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
reactant: MODEL1310110008#
reversible: false
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.4.3
product: MODEL1310110008#

metaR FAOXC162C162OHm
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:2-->C16:2OH)m
type: Reaction

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaM c4dc c
is: C02862
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: succinyl carnitine
constant: false
is: http://identifiers.org/pubchem.compound/213144
notes: FORMULA: C11H18NO6 CHARGE: -1
is: HMDB02013
type: Species

metaR HPDCACRNCPT1
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.2) or (1375.3) or (1374.1) or (126129.1) or (1375.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
reactant: MODEL1310110008#
is: SBO:0000176
type: Reaction
product: MODEL1310110008#
kinetic law: MODEL1310110008#
name: carnitine fatty-acyl transferase

http://identifiers.org/biomodels.db/MODEL1310110008#_72eef1a6_be5e_4fd4_8175_7b53176c81a7
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:6508
name: SLC4A3
has only substance units: false
is: SBO:0000252
is: P48751
constant: false
initial concentration: NaN

metaR NDP7ex
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
name: nucleoside-diphosphatase (UDP), extracellular
is version of: http://identifiers.org/ec-code/3.6.1.6
reversible: false
is: SBO:0000176
product: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#

metaR CHSTEROLt3
is: SBO:0000185
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110008#
type: Reaction
name: cholesterol intracellular transport
fast: false
reversible: true

metaR SUBEACTD
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberic acid into cytosol (diffusion)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_39ebfd74_42cc_478e_bb40_057df942bb32
is encoded by: hsa:5150
initial concentration: NaN
type: Species
is: SBO:0000252
name: PDE7A
initial amount: NaN
is: Q13946
boundary condition: true
has only substance units: false
constant: false

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaR PDE1
reversible: false
is: SBO:0000176
product: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.4.35
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
reactant: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.17
kinetic law: MODEL1310110008#
type: Reaction
name: 3',5'-cyclic-nucleotide phosphodiesterase

metaR TETDECE1CRNe
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tetradecenoyl carnitine into extra cellular space
type: Reaction

metaR RAI2
is described by: ECO:0000000
reactant: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
reversible: true
name: retinal isomerase (9-cis)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
product: MODEL1310110008#
fast: false
is: SBO:0000176

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_c252b69c_0634_457c_8eec_fe0795f39f0b
is: Q7L266
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: ASRGL1
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:80150

http://identifiers.org/biomodels.db/MODEL1310110008#_19159a28_1da3_414b_9690_724c60f72cea
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
name: ITPKB
is: P27987
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3707
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_40662659_4d4e_4f1d_ac47_9502eec13a79
has only substance units: false
initial concentration: NaN
name: PDE3B
is: SBO:0000252
is: A7E2E5
boundary condition: true
is encoded by: hsa:5140
constant: false
type: Species
initial amount: NaN

metaM hs deg3 l
name: heparan sulfate, degradation product 3
type: Species
is: CHEBI:16126
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_9dec2401_2096_4203_a5c4_59325ad98a17
initial concentration: NaN
is encoded by: hsa:8527
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: Q16760
is: SBO:0000252
name: DGKD
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_02660f5e_81d4_48a4_aabf_8ba5e6e685a7
name: _AA177072_1_c
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:AA177072
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR PDE4
is version of: http://identifiers.org/ec-code/3.1.4.35
is: SBO:0000176
modifier: MODEL1310110008#
name: 3',5'-cyclic-nucleotide phosphodiesterase
is described by: ECO:0000269
product: MODEL1310110008#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.17
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#

metaR G6PDH2rer
type: Reaction
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.47
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
modifier: MODEL1310110008#
fast: false
is: SBO:0000176
product: MODEL1310110008#
is described by: ECO:0000269
reactant: MODEL1310110008#
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
reversible: true

metaR DOLPMT2 Uer
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
is described by: ECO:0000000
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
kinetic law: MODEL1310110008#

metaR r0488
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
is: SBO:0000176
kinetic law: MODEL1310110008#
fast: false
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
type: Reaction

metaM CE4724 e
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5041
name: apelin (1-12)
constant: false
notes: FORMULA: C60H105N22O15S CHARGE: 3 INCHI: InChI=1/C60H102N22O15S/c1-33(2)27-40(77-50(88)37(12-6-21-69-59(64)65)74-55(93)44-15-9-24-81(44)56(94)38(13-7-22-70-60(66)67)75-48(86)35(62)17-18-46(63)84)51(89)79-42(31-83)53(91)78-41(28-34-29-68-32-72-34)52(90)73-36(11-4-5-20-61)49(87)71-30-47(85)80-23-8-14-43(80)54(92)76-39(19-26-98-3)57(95)82-25-10-16-45(82)58(96)97/h29,32-33,35-45,83H,4-28,30-31,61-62H2,1-3H3,(H2,63,84)(H,68,72)(H,71,87)(H,73,90)(H,74,93)(H,75,86)(H,76,92)(H,77,88)(H,78,91)(H,79,89)(H,96,97)(H4,64,65,69)(H4,66,67,70)/p+3/t35-,36-,37-,38+,39-,40+,41+,42-,43+,44+,45-/m1/s1 EHMN_ABBREVIATION: CE4724
is: C01936
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_79792f97_76dc_45bd_b787_56e4ad0516ab
name: CPT2
constant: false
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:1376
initial amount: NaN
is: SBO:0000252
is: P23786
initial concentration: NaN

metaM 3tetd7ecoa m
has only substance units: false
initial concentration: 1.0
name: 3-hydroxy tetradecenoyl-7-coa
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
is: HMDB05066

metaR FAOXC143C123x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)x
type: Reaction

metaR 2DR1PP
product: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false
name: 2-deoxy-D-ribose 1-phosphate phosphorylase
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110008#_150245b5_5862_4788_b450_49c5de3a4347
is encoded by: hsa:10935
initial amount: NaN
is: SBO:0000252
name: PRDX3
initial concentration: NaN
type: Species
has only substance units: false
is: E9PH29
boundary condition: true
constant: false

metaR CHSTEROLt1
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000185
name: cholesterol intracellular transport
reactant: MODEL1310110008#
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110008#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?

metaR FAOXC161C141m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:1-->C14:1)m
type: Reaction

metaR PI4P3K
reactant: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000000
name: phosphatidylinositol 4-phosphate 3-kinase
fast: false
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.154
product: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
is: SBO:0000176

metaR r1051
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110008#
name: Vesicular transport
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_e809df82_57e6_44f0_933a_841589c04cdf
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:8818
has only substance units: false
name: DPM2
is: O94777
type: Species
is: SBO:0000252

metaR RE3000M
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110008#
is described by: ECO:0000000
kinetic law: MODEL1310110008#
reversible: true
modifier: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
name: RE3000

metaR EHGLAT2m
reversible: false
product: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000304
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110008#_ef7d6d79_e915_49a0_9620_261bcfc60fd8
type: Species
name: ACSL4
constant: false
is encoded by: hsa:2182
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q5JWV8
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110008#_3217b9ba_25f5_4e98_b03f_fe905506507f
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
name: ATP5H
is: A0PJH2
is encoded by: hsa:10476
type: Species
initial concentration: NaN

metaM hexdiac r
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: hexadecanediocacid
is: SBO:0000247
type: Species
is: C08260
is: HMDB00672
constant: false
notes: FORMULA: C16H28O4 CHARGE: -2

metaR DGULND
name: dehydro-L-gulonate decarboxylase
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
product: MODEL1310110008#
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110008#

metaM ksii core2 deg2 l
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
constant: false
has only substance units: false
is: CHEBI:12936
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate II (core 2-linked), degradation product 2
boundary condition: false
is: HMDB00143
type: Species

metaR NACHEX2ly
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110008#
modifier: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
kinetic law: MODEL1310110008#
is described by: ECO:0000000

metaR FAOXC161802m
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
reversible: false
reactant: MODEL1310110008#
name: Beta oxidation fatty acid
kinetic law: MODEL1310110008#
product: MODEL1310110008#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110008#

metaR 4NPHSFte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
fast: false
product: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110008#
name: xenobiotic transport
type: Reaction
reversible: true
reactant: MODEL1310110008#

metaM ptrc c
is: SBO:0000247
is: HMDB01414
initial amount: NaN
is: CHEBI:326268
name: Putrescine
initial concentration: 1.0
boundary condition: false
is: C00134
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
has only substance units: false
type: Species
constant: false

metaM lnlncacoa c
initial concentration: 1.0
name: alpha-Linolenoyl-CoA
type: Species
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
is: CHEBI:51985
has only substance units: false
is: HMDB06290

metaM hs deg20 l
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
name: heparan sulfate, degradation product 20
is: CHEBI:16126
constant: false

metaM c6crn c
name: hexanoyl carnitine
notes: FORMULA: C13H25NO4 CHARGE: 0
is: HMDB00705
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN

metaM sphs1p c
is: HMDB00277
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:60119
has only substance units: false
constant: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
name: sphingosine 1-phosphate(1-)
is: SBO:0000247
initial amount: NaN

metaM 3hdeccoa c
initial concentration: 1.0
name: 3-hydroxyhexadecenoylcoa
initial amount: NaN
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
type: Species
is: HMDB02014
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false

metaR ETFQO
type: Reaction
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.5.1
reactant: MODEL1310110008#
is: SBO:0000176
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
product: MODEL1310110008#
name: Electron transfer flavoprotein-ubiquinone oxidoreductase

metaR C140CPT1
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of myristoylcarnitine
type: Reaction

metaR RE3301C
modifier: MODEL1310110008#
reversible: true
kinetic law: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.4.4
type: Reaction
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
name: RE3301
reactant: MODEL1310110008#

metaR FAOXC164C165x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_6b0d19fe_4dd1_43f6_ba6e_c2f5b62ffe8e
initial concentration: NaN
is encoded by: hsa:8395
has only substance units: false
name: PIP5K1B
initial amount: NaN
is: O14986
boundary condition: true
is: SBO:0000252
constant: false
type: Species

metaR RE2666C
is: SBO:0000176
reversible: false
name: RE2666
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:
reactant: MODEL1310110008#
type: Reaction

metaM xol7aone r
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
type: Species
is: HMDB01993
has only substance units: false
name: 7alpha-hydroxycholest-4-en-3-one
boundary condition: false
is: SBO:0000247
is: CHEBI:17899
constant: false
initial amount: NaN
initial concentration: 1.0

metaM c6crn e
initial concentration: 1.0
name: hexanoyl carnitine
notes: FORMULA: C13H25NO4 CHARGE: 0
is: HMDB00705
constant: false
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR sink dd2coa LPAREN c RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: DD2COASINK
type: Reaction

metaR FAOXC183C163m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_42a1f326_b137_467f_b5bd_509e170b572e
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:3295
is: E9PB82
has only substance units: false
name: HSD17B4
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_8a0b77c4_f59c_4025_bc60_56a6328d69ac
boundary condition: true
name: GCK
is: P35557
initial amount: NaN
is encoded by: hsa:2645
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM co2 r
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: HMDB01967
is: CHEBI:16526
has only substance units: false
is: C00011
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
name: CO2

metaR CGLYt3 2
is described by: ECO:0000304
kinetic law: MODEL1310110008#
fast: false
product: MODEL1310110008#
name: Cys-Gly transport in via proton symport
is: SBO:0000185
reactant: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB

metaR DCSPTN1CRNt
is: SBO:0000185
type: Reaction
name: transport into the mitochondria (carnitine)
fast: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
product: MODEL1310110008#
reversible: false

metaR r0483
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110008#
is: SBO:0000176
reversible: true
fast: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
product: MODEL1310110008#

metaR FAOXC12DCTc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dodecanedioyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_08921951_19f9_4075_a49d_ed96ef6c687b
initial amount: NaN
is encoded by: hsa:BG035985
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: _BG035985_1_c
boundary condition: true
constant: false

metaM dcacoa c
is: CHEBI:61430
is: C05274
boundary condition: false
type: Species
constant: false
is: HMDB06404
name: Decanoyl-CoA (n-C10:0CoA)
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
has only substance units: false

metaM sphs1p e
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: CHEBI:60119
name: sphingosine 1-phosphate(1-)
initial amount: NaN
boundary condition: false
is: HMDB00277

metaR FAS100COA
reversible: false
modifier: MODEL1310110008#
fast: false
type: Reaction
name: fatty acyl-CoA synthase (n-C10:0CoA)
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110008#
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110008#_820f0d95_9c73_4ce4_9a7f_79df7e8e3f34
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:29968
has only substance units: false
name: PSAT1
type: Species
boundary condition: true

metaR FAOXC102C103m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_8ab2d81b_33f1_41e0_9735_b7ead907cbd1
is encoded by: hsa:6487
type: Species
initial concentration: NaN
name: ST3GAL3
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: Q5T4W8
is: SBO:0000252

metaM csn e
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
is: HMDB00630
boundary condition: false
name: cytosine
initial concentration: 1.0
is: CHEBI:16040
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_d0a63b35_4473_4fe9_ad82_4d5c23e9659c
type: Species
name: _AV727634_1_c
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AV727634

http://identifiers.org/biomodels.db/MODEL1310110008#_d185fcf5_e828_4b17_aa83_782c534a2c54
boundary condition: true
is encoded by: hsa:5295
has only substance units: false
initial concentration: NaN
name: PIK3R1
is: P27986
initial amount: NaN
type: Species
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110008#_2767cf07_b634_43e2_ba29_604c7f392bb2
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P53794
name: SLC5A3
constant: false
boundary condition: true
is encoded by: hsa:6526

http://identifiers.org/biomodels.db/MODEL1310110008#_02eaeb5e_60cf_42a0_8d30_a97945e0bb08
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: COL4A3BP
type: Species
boundary condition: true
has only substance units: false
constant: false
is: Q9Y5P4
is encoded by: hsa:10087

http://identifiers.org/biomodels.db/MODEL1310110008#_e3439f09_63ef_4cdd_90e3_82dfd6abc997
is: SBO:0000252
initial amount: NaN
type: Species
name: GSR
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:2936
is: P00390
constant: false

metaM 3dsphgn c
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
has only substance units: false
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
is: HMDB01480
is: CHEBI:58299
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_ce3a0ac5_8acb_450a_91f5_1c51bde7ae73
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
name: _AI222095_1_e
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI222095
type: Species

metaR RE1709N
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/4.2.1.96
name: RE1709
reactant: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110008#
reversible: true
modifier: MODEL1310110008#
is: SBO:0000176

metaR C81CRNe
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octenoyl carnitine into the extra cellular space
type: Reaction

metaM ksii core2 pre1 g
name: keratan sulfate II biosynthesis, precursor 1
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C33H53N3O23X CHARGE: -1
boundary condition: false
is: CHEBI:28067
type: Species

metaM 4hexdtricoa x
constant: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial concentration: 1.0
name: 4,7,10-hexadecatrienoylcoa
type: Species
has only substance units: false
initial amount: NaN
is: HMDB02288
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_19468baa_17ee_4a3f_8d12_52d4fc88f56d
type: Species
boundary condition: true
is encoded by: hsa:1737
initial concentration: NaN
name: DLAT
is: SBO:0000252
initial amount: NaN
constant: false
is: Q86YI5
has only substance units: false

metaR G5SADrm
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
type: Reaction
reactant: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
is described by: ECO:0000000
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
product: MODEL1310110008#
is: SBO:0000176

metaM 3tetd7ecoa c
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
name: 3-hydroxy tetradecenoyl-7-coa
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB05066

metaM csn c
boundary condition: false
is: HMDB00630
initial amount: NaN
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
type: Species
initial concentration: 1.0
name: cytosine
is: CHEBI:16040
has only substance units: false
is: SBO:0000247
constant: false

metaR OAADC
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: oxaloacetate decarboxylase
type: Reaction

metaR FAOXC161C161OHm
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of 3-hydroxyhexadecenoylcoA
type: Reaction

metaR MI14PP
reactant: MODEL1310110008#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.57
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
name: inositol-1,4-bisphosphate 1-phosphatase
kinetic law: MODEL1310110008#
product: MODEL1310110008#
modifier: MODEL1310110008#

metaR SIAASEly
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110008#
fast: false
reversible: false
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
name: sialidase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaM ksii core2 pre3 g
notes: FORMULA: C47H76N4O33X CHARGE: -1
type: Species
is: CHEBI:58053
initial amount: NaN
is: HMDB00175
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 3
is: C00130
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR r0480
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is: SBO:0000176
product: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
reversible: true
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_63b47321_fc1c_44ef_9c3b_3e3625e7e451
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:353
is: P07741
constant: false
name: APRT
is: SBO:0000252

metaR RE1532M
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110008#
product: MODEL1310110008#
name: RE1532
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM HC02213 e
is: SBO:0000247
constant: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
is: CHEBI:28031
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: prostaglandin-e3
type: Species
boundary condition: false

metaM acac m
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
name: acetoacetate
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: HMDB00060
initial concentration: 1.0
is: CHEBI:13705
has only substance units: false

metaM cmp n
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB00095
name: CMP(2-)
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:60377
initial concentration: 1.0

metaR FAOXC101C102x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)x
type: Reaction

metaR C80CPT1
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of octanoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_8de9c865_04ed_4b0d_adcd_25cbed585b99
initial amount: NaN
is encoded by: hsa:H17063
name: _H17063_1_c
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
constant: false

metaR HPYRtp
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
name: hydroxypyruate transport, peroxisomal
product: MODEL1310110008#
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12185464 NOTES:NCD
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110008#_f135ce2c_a823_45ad_9a19_3e433b38ba56
is: SBO:0000252
boundary condition: true
name: ALDH9A1
has only substance units: false
type: Species
is encoded by: hsa:223
initial concentration: NaN
constant: false
initial amount: NaN
is: P49189

metaM dopa c
boundary condition: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: CHEBI:59905
type: Species
has only substance units: false
is: HMDB00073
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: dopaminium(1+)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_ad4a0fd5_0cd3_4ed1_9d10_cd24595f6d90
is encoded by: hsa:4830
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000297
initial amount: NaN
initial concentration: NaN
constant: false
name: NME1:NME2

metaR PHEACGLNt
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
reversible: true
fast: false
name: PHEACGLN extracellular transport via diffusion
type: Reaction
product: MODEL1310110008#
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_729ea2f4_b0c1_4f05_863c_bcd4724a075c
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaM dgchol x
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
constant: false
name: glycochenodeoxycholate
is: HMDB00637
has only substance units: false
is: CHEBI:36252
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_3430dea9_2038_4a05_96d0_725f88eaea4a
type: Species
initial amount: NaN
is: P08237
has only substance units: false
is encoded by: hsa:5213
boundary condition: true
name: PFKM
is: SBO:0000252
constant: false
initial concentration: NaN

metaM g6p c
initial amount: NaN
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
constant: false
has only substance units: false
is: CHEBI:61548
initial concentration: 1.0
name: D-Glucose 6-phosphate
is: C00092
is: SBO:0000247
is: HMDB01401
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_fe6d338b_632d_4aed_b649_a3497ece9b46
is encoded by: hsa:84720
initial amount: NaN
has part: Q07326
name: PIGF:PIGO
is: SBO:0000297
boundary condition: true
is encoded by: hsa:5281
has part: Q8TEQ8
type: Species
constant: false
initial concentration: NaN
has only substance units: false

metaR r0655
type: Reaction
modifier: MODEL1310110008#
product: MODEL1310110008#
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000176

metaM cmp m
initial amount: NaN
is: CHEBI:60377
name: CMP(2-)
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
is: HMDB00095
initial concentration: 1.0
constant: false

metaM co2 m
initial amount: NaN
is: CHEBI:16526
name: CO2
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: C00011
initial concentration: 1.0
constant: false
is: HMDB01967

metaR AG13T14g
type: Reaction
reversible: false
modifier: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110008#

metaR FAOXC164C143x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)x
type: Reaction

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaR PRFGS
product: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#
reversible: false
name: phosphoribosylformylglycinamidine synthase
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/6.3.5.3
fast: false
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110008#_2dd75e7b_95af_450b_a09e_d70a5b46d200
type: Species
has only substance units: false
initial amount: NaN
name: ECHS1
initial concentration: NaN
is encoded by: hsa:1892
boundary condition: true
constant: false
is: SBO:0000252
is: P30084

metaR TDCRNe
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of myristoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_881ec856_3c73_4738_8221_b23df7aa3b0b
name: SLC4A10
is: B7Z1R0
has only substance units: false
is encoded by: hsa:57282
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
constant: false

metaR S2TASE2ly
product: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
name: iduronate-2-sulfatase, lysosomal
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.6.13
is: SBO:0000176
reversible: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
fast: false
modifier: MODEL1310110008#

metaR DOLGLCP Uter
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
product: MODEL1310110008#
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)
reactant: MODEL1310110008#
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110008#

metaM dhcholoylcoa x
boundary condition: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
type: Species
is: HMDB06895
is: CHEBI:27393
initial amount: NaN

metaR CYTK12n
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dCTP),nuclear
modifier: MODEL1310110008#
reversible: true
product: MODEL1310110008#
fast: false
is: SBO:0000176
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
kinetic law: MODEL1310110008#

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_58417d3c_e7fd_40aa_8c3e_8115e2d47e44
has only substance units: false
is encoded by: hsa:51301
boundary condition: true
constant: false
is: Q9P109
is: SBO:0000252
initial amount: NaN
name: GCNT4
initial concentration: NaN
type: Species

metaR r1566
is described by: ECO:0000000
product: MODEL1310110008#
kinetic law: MODEL1310110008#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110008#
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR ASPTAm
reactant: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
type: Reaction
name: aspartate transaminase
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000269
is: SBO:0000176
fast: false
product: MODEL1310110008#

metaR MALSO4tm
fast: false
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000269
is: SBO:0000185
reversible: true
modifier: MODEL1310110008#
name: Malate:sulfate antiport, mitochondrial
type: Reaction

metaM dhdascb c
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
constant: false
name: dehydroascorbide(1-)
is: HMDB01264
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:58070
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_69a4d9c1_fd1e_48a7_89d1_0e3e5dc382cb
constant: false
boundary condition: true
is: B4DX62
is: SBO:0000252
is encoded by: hsa:6487
initial amount: NaN
type: Species
name: ST3GAL3
has only substance units: false
initial concentration: NaN

metaM thr L e
initial concentration: 1.0
name: L-threonine
is: SBO:0000247
type: Species
is: CHEBI:16857
boundary condition: false
constant: false
is: HMDB00167
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
initial amount: NaN
has only substance units: false

metaM HC02213 c
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
boundary condition: false
name: prostaglandin-e3
is: CHEBI:28031
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_6431d172_7f4c_49f3_9a2c_f8043b40cc26
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:728441
type: Species
constant: false
initial concentration: NaN
name: GGT2

metaR OPAHir
reactant: MODEL1310110008#
name: 5-Oxoproline amidohydrolase (ATP-hydrolysing) (ir)
reversible: false
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (26873.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.5.2.9 Confidence Level: 4 AUTHORS: PMID:9751079 NOTES:AF Added from KEGG
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.5.2.9
is described by: ECO:0000134
product: MODEL1310110008#
modifier: MODEL1310110008#

metaR r1567
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110008#
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: true
type: Reaction

metaM r1p c
is: HMDB01489
name: alpha-D-Ribose 1-phosphate
initial concentration: 1.0
is: CHEBI:57720
boundary condition: false
initial amount: NaN
is: C00442
has only substance units: false
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
type: Species
constant: false
is: SBO:0000247

metaR r0650
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.36
modifier: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110008#
reversible: true
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is described by: ECO:0000000

metaR HOCTDECCRNe
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyoctadecanoyl carnitine into extra cellular space
type: Reaction

metaR MECOALm
product: MODEL1310110008#
kinetic law: MODEL1310110008#
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
is described by: ECO:0000212
reactant: MODEL1310110008#
is: SBO:0000176
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/6.2.1.4
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.2.1.5

metaR LGNCCOAtx
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
is described by: ECO:0000000
product: MODEL1310110008#
reversible: true
fast: false
name: fatty acid intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_7d56271b_e4b1_4946_ace9_88d13d3e0a34
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:205
boundary condition: true
constant: false
is: P27144
initial amount: NaN
name: AK4

metaR PIt7
fast: false
kinetic law: MODEL1310110008#
reversible: true
reactant: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
name: phosphate transport in/out via three Na+ symporter
product: MODEL1310110008#
is described by: ECO:0000269
is: SBO:0000185

metaM m3mpdol U c
initial amount: NaN
boundary condition: false
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human uterine homolog
notes: FORMULA: C1425H2340N20O370P20 CHARGE: -20
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:37632
constant: false

metaR UAGALDP
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: UDP-N-acetylgalactosamine diphosphorylase
is: SBO:0000176
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000
reversible: false
fast: false

metaR PRGNLONEtr
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110008#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110008#
name: pregnenolone intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
fast: false
product: MODEL1310110008#

metaM lnlccrn c
is: HMDB06469
boundary condition: false
has only substance units: false
type: Species
name: Linoleyl carnitine
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
initial amount: NaN
constant: false

metaR r0651
type: Reaction
kinetic law: MODEL1310110008#
reversible: true
fast: false
product: MODEL1310110008#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is version of: http://identifiers.org/ec-code/1.5.1.2
modifier: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
reactant: MODEL1310110008#
is: SBO:0000176

metaR r1564
reactant: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110008#
fast: false
is: SBO:0000185
reversible: true
type: Reaction

metaM prpncoa m
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
has only substance units: false
is: CHEBI:57367
is: HMDB02307
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
name: acryloyl-CoA(4-)
boundary condition: false

metaR PIt8
is described by: ECO:0000006
reversible: true
fast: false
name: phosphate transport in/out via Na+ symporter
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
modifier: MODEL1310110008#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110008#
product: MODEL1310110008#
kinetic law: MODEL1310110008#

metaR 5AOPtm
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10558864 NOTES:NCD. Delta-aminolevulinic acid is produced in mitochondria then converted to PBG in the cytoplasm. Could not find anything on the transporter itself.
name: 5-Aminolevulinate mitochondrial transport
is: SBO:0000185
type: Reaction
is described by: ECO:0000134
fast: false
product: MODEL1310110008#

metaM ksii core4 e
initial concentration: 1.0
name: keratan sulfate II (core 4-linked)
is: HMDB00211
is: CHEBI:17268
initial amount: NaN
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
is: SBO:0000247
type: Species
boundary condition: false
constant: false
has only substance units: false

metaM 2docopencoa x
has only substance units: false
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
name: 2,7,10,13,16-docosapentenoylcoa
type: Species
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
initial concentration: 1.0
constant: false

metaR r1565
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#
reactant: MODEL1310110008#
reversible: true

metaR C18OHc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecanoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_1759887f_7811_4c62_b5f1_b87a279f2c6b
type: Species
constant: false
is: SBO:0000252
name: CMPK1
is: B2R6S5
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:51727
has only substance units: false

metaR GALK
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.1.157
fast: false
reversible: false
product: MODEL1310110008#
modifier: MODEL1310110008#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.6
name: galactokinase
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
reactant: MODEL1310110008#
is described by: ECO:0000000

metaM ksi deg6 l
initial amount: NaN
name: keratan sulfate I, degradation product 6
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
is: HMDB00143
constant: false
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:12936
boundary condition: false
initial concentration: 1.0

metaM 7thf e
name: heptaglutamyl folate (THF)
boundary condition: false
is: HMDB06559
is: SBO:0000247
notes: FORMULA: C49H57N13O24 CHARGE: -8
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
initial amount: NaN

metaR FAOXC14C12m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_331f4b46_4bec_4fb4_b7ea_ffe0566002be
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:2181
is: O95573
name: ACSL3
type: Species

metaM glyc m
name: Glycerol
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: HMDB00131
initial amount: NaN
type: Species
is: C00116
is: CHEBI:17754
boundary condition: false
constant: false
initial concentration: 1.0

metaR FAOXC8C6m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)m
type: Reaction

metaR HDECEACBP
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecenoylcoa from mitochondria into the cytosol
type: Reaction

metaR PMTCOAtx
name: fatty acid intracellular transport
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
reversible: true
product: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

http://identifiers.org/biomodels.db/MODEL1310110008#_62c7cfb6_ccaf_4bd9_990d_0f146a050deb
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:3420
has only substance units: false
name: IDH3B

metaM guln r
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
name: L-gulonate
is: CHEBI:13115
initial concentration: 1.0
type: Species
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
is: HMDB03290
initial amount: NaN

metaM oxa c
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB02329
has only substance units: false
name: oxalate(2-)
is: SBO:0000247
type: Species
is: CHEBI:30623
boundary condition: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209

metaM pentcoa m
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
type: Species
is: C00888
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB13037
name: pentanoylcoa

http://identifiers.org/biomodels.db/MODEL1310110008#_3a778739_d67c_47c0_855c_2a96d66b491d
has only substance units: false
is encoded by: hsa:10195
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
type: Species
name: ALG3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_613238d6_c6bd_4f14_9837_72c137db6835
boundary condition: true
name: MAN2B1
type: Species
is: O00754
constant: false
initial amount: NaN
is encoded by: hsa:4125
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM fdp c
name: D-Fructose 1,6-bisphosphate
initial concentration: 1.0
is: C00354
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:16905
constant: false
initial amount: NaN
is: HMDB01058
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
is: http://identifiers.org/pubchem.compound/3647
is: SBO:0000247

metaM mescon m
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
name: Mesaconate
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00749
is: CHEBI:36986

metaM lnlncacrn c
type: Species
is: HMDB06319
name: alpha-linolenyl carnitine
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
initial concentration: 1.0

metaM 3tetd7ecoacrn c
type: Species
name: 3-hydroxy tetradecenoyl-7-carnitine
initial amount: NaN
has only substance units: false
constant: false
is: HMDB02014
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C21H39NO5 CHARGE: 0

metaM 3tetd7ecoacrn e
notes: FORMULA: C21H39NO5 CHARGE: 0
constant: false
name: 3-hydroxy tetradecenoyl-7-carnitine
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB02014
type: Species

metaM xol7a r
type: Species
boundary condition: false
is: HMDB01496
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
is: CHEBI:1296
name: 20-hydroxycholesterol

http://identifiers.org/biomodels.db/MODEL1310110008#_cfbce162_a791_437c_8290_5edfa8f657e8
initial amount: NaN
is: P31939
initial concentration: NaN
type: Species
name: ATIC
has only substance units: false
is encoded by: hsa:471
boundary condition: true
is: SBO:0000252
constant: false

metaR GLCNACPT U
reversible: false
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110008#
is: SBO:0000176
modifier: MODEL1310110008#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.8.15
fast: false
kinetic law: MODEL1310110008#
type: Reaction
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (uterus)
product: MODEL1310110008#

metaR TALA
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
name: transaldolase
reversible: true
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.2.1.2
modifier: MODEL1310110008#
is: SBO:0000176

metaM ksii core4 g
initial amount: NaN
type: Species
is: CHEBI:17140
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial concentration: 1.0
name: keratan sulfate II (core 4-linked)
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB01644
has only substance units: false

metaR C12DCTD
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Dodecanedioic acid by diffusion
type: Reaction

metaM 2mop m
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01172
is: CHEBI:57700
name: 2-methyl-3-oxopropanoate
constant: false
type: Species
has only substance units: false

metaM ppa m
is: CHEBI:17272
initial amount: NaN
name: propionate
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
type: Species
is: HMDB00237
boundary condition: false
has only substance units: false
constant: false

metaR G14T20g
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110008#
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110008#
type: Reaction

metaM pail hs c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:57880
type: Species
constant: false
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol(1-)
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
has only substance units: false

metaR FAOXC163C142x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)x
type: Reaction

metaM 3spyr c
name: 3-sulfonatopyruvate(2-)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H2O6S CHARGE: -2 INCHI: InChI=1S/C3H4O6S/c4-2(3(5)6)1-10(7,8)9/h1H2,(H,5,6)(H,7,8,9)/p-2 EHMN_ABBREVIATION: C05528
constant: false
type: Species
initial amount: NaN
is: CHEBI:57940
is: HMDB04045
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_76babc56_7859_4497_8b60_24666d5cf7e8
type: Species
has only substance units: false
initial concentration: NaN
name: PCBD1
constant: false
boundary condition: true
is encoded by: hsa:5092
is: SBO:0000252
initial amount: NaN
is: P61457

metaR FAOXC183806m
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
reversible: false
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of fatty acid
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
product: MODEL1310110008#
modifier: MODEL1310110008#

metaM dolp U c
is: SBO:0000247
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:57683
constant: false
type: Species
name: dolichyl phosphate(2-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_c324bed7_ac04_4e6c_837b_4ead1af0c0e0
has only substance units: false
is: SBO:0000252
boundary condition: true
name: AMPD2
is: B2RB47
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:271
initial concentration: NaN

metaR EX ivcrn
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for isovaleryl carnitine
type: Reaction

metaM oxa e
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:30623
initial amount: NaN
is: HMDB02329
name: oxalate(2-)
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_bf93273a_6a7e_4474_8a5c_f647345e3b75
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2954
constant: false
boundary condition: true
initial amount: NaN
type: Species
name: GSTZ1
is: SBO:0000252
is: A6NED0

metaR r1568
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110008#
reversible: true
product: MODEL1310110008#
type: Reaction

metaM 2hb e
is: HMDB00008
has only substance units: false
name: 2-Hydroxybutyrate
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
is: CHEBI:1148
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species

metaM ptrc e
is: HMDB01414
boundary condition: false
constant: false
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
initial amount: NaN
is: CHEBI:326268
is: SBO:0000247
initial concentration: 1.0
name: Putrescine
is: C00134
has only substance units: false
type: Species

metaM xol7aone m
constant: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
has only substance units: false
boundary condition: false
is: CHEBI:17899
type: Species
is: HMDB01993
initial amount: NaN
initial concentration: 1.0
name: 7alpha-hydroxycholest-4-en-3-one
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_a76398c5_72c0_41a1_906c_6ec71a5e67bb
initial amount: NaN
name: HK1
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:3098
type: Species
initial concentration: NaN
is: P19367
is: SBO:0000252

metaM dudp c
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB01000
is: CHEBI:60471
is: C01346
is: SBO:0000247
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
name: dUDP

metaR XOLDIOLONEt
fast: false
is: SBO:0000185
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
product: MODEL1310110008#
reversible: true

metaM thr L c
name: L-threonine
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00167
type: Species
is: CHEBI:16857
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_b5238cf6_3cdb_4063_bb08_ff5d9fb146ec
name: SLCO4A1
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
is: Q96BD0
type: Species
initial concentration: NaN
is encoded by: hsa:28231

metaR GPIAT
modifier: MODEL1310110008#
reversible: false
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
name: glucosaminylphosphatidyl inositol acetyltransferase
reactant: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
is: SBO:0000176
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110008#

metaM 2hb c
is: SBO:0000247
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
is: HMDB00008
name: 2-Hydroxybutyrate
boundary condition: false
has only substance units: false
is: CHEBI:1148
initial concentration: 1.0
constant: false
initial amount: NaN

metaM ksi pre16 g
boundary condition: false
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 16
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
has only substance units: false
is: C00130
type: Species
constant: false
is: HMDB00175

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaR CLFORtex
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
name: chloride transport via formate countertransport
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is: SBO:0000185
is described by: ECO:0000304
reversible: false
fast: false
product: MODEL1310110008#
modifier: MODEL1310110008#

metaM utp e
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: UTP(4-)
is: CHEBI:46398
type: Species
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
initial amount: NaN
is: HMDB00285
constant: false
has only substance units: false

metaR PROSTGE2t2
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110008#
name: prostaglandin uniport
product: MODEL1310110008#
reversible: true
modifier: MODEL1310110008#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
kinetic law: MODEL1310110008#

metaM mi14p c
initial concentration: 1.0
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
is: SBO:0000247
is: CHEBI:58282
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
initial amount: NaN
has only substance units: false
is: HMDB00968
type: Species
boundary condition: false
constant: false

metaR r1569
is: SBO:0000185
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM cs a deg1 l
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB01354
type: Species
initial amount: NaN
is: CHEBI:57455
has only substance units: false
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
is: SBO:0000247

metaM m8mpdol U r
initial amount: NaN
constant: false
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:59093
notes: FORMULA: C1725H2840N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1
boundary condition: false
initial concentration: 1.0

metaR ATPtx
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110008#
reversible: true
type: Reaction
kinetic law: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
name: ATP transporter, peroxisomal
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_52c612ce_09e4_47ec_b391_f9031bff0645
is: Q9H6Y6
type: Species
initial concentration: NaN
is encoded by: hsa:4645
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: MYO5B
constant: false

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaR r0193
kinetic law: MODEL1310110008#
is: SBO:0000176
product: MODEL1310110008#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110008#
type: Reaction
fast: false
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110008#_1200f1d8_ce09_4d0b_ae60_1e0ab31226d9
initial concentration: NaN
name: _AI378339_1_m
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:AI378339

metaM prgnlone r
name: pregnenolone
type: Species
constant: false
is: CHEBI:16581
has only substance units: false
boundary condition: false
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00253

metaM ksi deg18 l
constant: false
is: HMDB00143
initial concentration: 1.0
name: keratan sulfate I, degradation product 18
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
has only substance units: false
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110008#_e0335fa0_215d_40aa_817b_ca009ebec922
has only substance units: false
is encoded by: hsa:AA788780
boundary condition: true
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: _AA788780_1_c

metaM utp c
is: CHEBI:46398
is: HMDB00285
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
constant: false
has only substance units: false
is: C00075
initial amount: NaN
name: UTP
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM thbpt4acam c
name: 4a-hydroxytetrahydrobiopterin
has only substance units: false
initial amount: NaN
is: CHEBI:15374
constant: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
boundary condition: false
is: SBO:0000247
is: HMDB02281
type: Species
initial concentration: 1.0

metaM glyc c
initial concentration: 1.0
is: HMDB00131
type: Species
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: CHEBI:17754
is: C00116
is: SBO:0000247
name: Glycerol
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN

metaR RE1709C
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
product: MODEL1310110008#
name: RE1709
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110008#
reversible: true
kinetic law: MODEL1310110008#

metaM retinal cis 9 c
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB01358
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
initial concentration: 1.0
is: CHEBI:17898
constant: false
name: all-trans-retinal
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_a945aa66_d483_4459_9b73_4ea03468b00d
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
name: PNP
is: P00491
has only substance units: false
is encoded by: hsa:4860
constant: false
boundary condition: true

metaR TRPt
type: Reaction
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110008#
name: L-tryptophan transport
is: SBO:0000185
fast: false

metaR PRGNLONEtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction
fast: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: pregnenolone intracellular transport

metaR r0191
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.24
modifier: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
is described by: ECO:0000000
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
reactant: MODEL1310110008#
reversible: false
fast: false
product: MODEL1310110008#

metaM tethex3coa c
has only substance units: false
constant: false
is: C16168
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
is: HMDB06243
is: http://identifiers.org/pubchem.compound/47205478
boundary condition: false
initial amount: NaN
type: Species
name: tetracosahexaenoyl coenzyme A
initial concentration: 1.0
is: SBO:0000247

metaM xol7aone c
initial concentration: 1.0
type: Species
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB01993
constant: false
name: 7alpha-hydroxycholest-4-en-3-one
is: CHEBI:17899
initial amount: NaN

metaR FAOXTC122m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization trans(C12:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_f6351e01_d6c2_4493_af58_45873c2dadcc
is encoded by: hsa:4124
initial amount: NaN
name: MAN2A1
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is: Q16706

metaR GASNASE3ly
modifier: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
reversible: false
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.5.1.26
type: Reaction
is described by: ECO:0000000
fast: false
name: glycosylasparaginase, lysosomal
kinetic law: MODEL1310110008#
product: MODEL1310110008#

metaM CE2839 e
boundary condition: false
is: C01936
initial concentration: 1.0
has only substance units: false
name: maltodecaose
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
type: Species
constant: false

metaR C2tcx
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of acetylcarnitine from peroxisomes to cytosol
type: Reaction

metaR EX HC00822 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chitobiose exchange
type: Reaction

metaM retfa c
type: Species
is: CHEBI:50211
is: SBO:0000247
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
initial concentration: 1.0
is: HMDB00305
initial amount: NaN
has only substance units: false
boundary condition: false
name: fatty acid retinol
constant: false

metaM gam6p c
initial amount: NaN
name: D-Glucosamine 6-phosphate
is: HMDB01254
is: CHEBI:12962
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
initial concentration: 1.0
constant: false

metaM methf c
boundary condition: false
type: Species
constant: false
is: C00445
name: 5,10-Methenyltetrahydrofolate
initial concentration: 1.0
is: SBO:0000247
is: HMDB01354
initial amount: NaN
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: CHEBI:57455
has only substance units: false

metaR 10FTHFtm
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reversible: true
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
kinetic law: MODEL1310110008#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_18e9de8d_21e4_4820_9f59_d9325f2a6578
boundary condition: true
is encoded by: hsa:80704
is: Q9BZV2
initial amount: NaN
initial concentration: NaN
name: SLC19A3
is: SBO:0000252
has only substance units: false
type: Species
constant: false

metaR ADAe
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.4.4
product: MODEL1310110008#
is: SBO:0000176
name: Adenosine deaminase, extracellular
fast: false

metaR EX 4pyrdx LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Pyridoxate exchange
type: Reaction

metaM c12dc c
type: Species
name: dodecanedioyl carnitine
is: HMDB00623
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C19H34NO6 CHARGE: -1

metaM hexdiac c
is: C08260
is: SBO:0000247
has only substance units: false
type: Species
constant: false
notes: FORMULA: C16H28O4 CHARGE: -2
boundary condition: false
is: HMDB00672
name: hexadecanediocacid
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_0e7c754c_45a9_46ee_9f89_7a6dc6395d4b
is: SBO:0000252
initial amount: NaN
name: MDH1B
is: Q5I0G3
initial concentration: NaN
is encoded by: hsa:130752
boundary condition: true
has only substance units: false
constant: false
type: Species

metaM dmnoncrn x
boundary condition: false
is: HMDB06202
is: SBO:0000247
constant: false
has only substance units: false
name: 4,8-dimethylnonanoyl carnitine
notes: FORMULA: C18H37NO4 CHARGE: 0
initial concentration: 1.0
type: Species
initial amount: NaN

metaM glyc e
constant: false
initial concentration: 1.0
is: C00116
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
boundary condition: false
is: CHEBI:17754
has only substance units: false
is: HMDB00131
initial amount: NaN
type: Species
name: Glycerol
is: SBO:0000247

metaR HIVCACBP
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyisovalerylcoa from mitochondria into the cytosol
type: Reaction

metaR EX arachcoa LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: arachidyl coenzyme A exchange
type: Reaction

metaM ksii core4 pre8 g
initial concentration: 1.0
constant: false
notes: FORMULA: C83H134N7O61SX CHARGE: -2
is: C00130
is: SBO:0000247
is: HMDB00175
type: Species
is: CHEBI:58053
boundary condition: false
has only substance units: false
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 8

metaR C3DCe
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of malonyl carnitine into extra cellular space
type: Reaction

metaR TTDCAtr
reactant: MODEL1310110008#
reversible: true
name: tetradecanoate (transport)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110008#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_b5e1dc07_390d_4870_924f_4f9b44c65ee8
is: P22413
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:5167
name: ENPP1

metaR r1562
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110008#
is: SBO:0000185
reversible: true
type: Reaction
fast: false

metaR DNDPt8m
product: MODEL1310110008#
kinetic law: MODEL1310110008#
name: dADP transport via dUDP antiport
is described by: ECO:0000269
type: Reaction
reversible: false
is: SBO:0000185
fast: false
reactant: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110008#_73996f19_cf46_4a7d_8f34_82e469eb8e30
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:8897
initial amount: NaN
constant: false
name: MTMR3
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_c9f1040f_db24_44dd_ac92_c6f7f33ff275
boundary condition: true
name: _AA278423_1_c
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AA278423
constant: false

metaR EX 3ttetddcoacrn
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy trans5,8tetradecadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_817e78e3_4202_4417_b457_79a7b195c059
constant: false
has only substance units: false
name: GGT5
is: P36269
initial amount: NaN
is encoded by: hsa:2687
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true

metaR 4PYRDX
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT Reaction correct??? (active transport)
fast: false
name: 4-Pyridoxal secretion
product: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000185
kinetic law: MODEL1310110008#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_f31a67b7_12ad_46fd_8d2b_928f39b35bc9
is: SBO:0000252
initial amount: NaN
name: DGKZ
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8525
is: G3V0F6
type: Species
boundary condition: true

metaR C142OHe
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:2-OH
type: Reaction

metaM dcyt e
initial amount: NaN
is: HMDB00014
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: Deoxycytidine
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: CHEBI:15698
boundary condition: false
type: Species
is: C00881

metaM g6p r
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:61548
has only substance units: false
constant: false
name: D-Glucose 6-phosphate
is: C00092
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: HMDB01401

metaR MALTSULtm
kinetic law: MODEL1310110008#
is described by: ECO:0000269
type: Reaction
name: Malate:thiosulfate antiport, mitochondrial
product: MODEL1310110008#
is: SBO:0000185
reactant: MODEL1310110008#
modifier: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false

metaR r1563
reversible: true
is: SBO:0000185
reactant: MODEL1310110008#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110008#
type: Reaction

metaR S6T17g
reversible: false
reactant: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
type: Reaction

metaR r0196
reversible: true
product: MODEL1310110008#
is described by: ECO:0000000
reactant: MODEL1310110008#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000176
fast: false

metaR r0381
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
is described by: ECO:0000000
kinetic law: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
type: Reaction
is: SBO:0000176
product: MODEL1310110008#
reversible: true
reactant: MODEL1310110008#

metaR R group phosphotase 2
kinetic law: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110008#
reversible: false
type: Reaction
fast: false
name: R group phosphotase 2

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR STS1
product: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.6.2
reversible: false
type: Reaction
reactant: MODEL1310110008#
is: SBO:0000176
modifier: MODEL1310110008#
name: Steryl-sulfatase
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ

metaM ppa e
is: HMDB00237
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
name: propionate
initial amount: NaN
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial concentration: 1.0
is: CHEBI:17272
type: Species

metaR CYTK4n
type: Reaction
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reversible: true
product: MODEL1310110008#
kinetic law: MODEL1310110008#
name: cytidylate kinase (dCMP,GTP),nuclear
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110008#_a11ce74a_6609_44e3_bfa6_d6b17a190bd5
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6799
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: SULT1A2

metaR DOPASFt
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110008#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
kinetic law: MODEL1310110008#
is: SBO:0000185
name: Dopamine 3-0-sulfate transport (diffusion)
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_0c45afae_42d0_4011_849e_aaae4a93cc91
type: Species
boundary condition: true
name: CA14
has only substance units: false
is encoded by: hsa:23632
is: A8K3J4
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

metaR R group phosphotase 1
type: Reaction
kinetic law: MODEL1310110008#
name: R group phosphotase 1
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
product: MODEL1310110008#
fast: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110008#

metaM dcyt c
initial amount: NaN
is: CHEBI:15698
type: Species
boundary condition: false
has only substance units: false
is: C00881
name: Deoxycytidine
initial concentration: 1.0
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: HMDB00014
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_f6ebab38_b0e2_4987_910a_abcf442a0e6a
is encoded by: hsa:6240
name: RRM1
is: P23921
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR r1560
type: Reaction
reversible: true
product: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110008#

metaR EICOSTETt
name: fatty acid transport via diffusion
reactant: MODEL1310110008#
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110008#
is: SBO:0000185
kinetic law: MODEL1310110008#

metaR NDP7er
kinetic law: MODEL1310110008#
is described by: ECO:0000000
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
is: SBO:0000176
product: MODEL1310110008#
reversible: false
fast: false
reactant: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD

metaR CDPDAGtm
kinetic law: MODEL1310110008#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
product: MODEL1310110008#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110008#
reversible: true
name: intracellular transport

metaM glyc S e
notes: FORMULA: C3H5O4 CHARGE: 0
name: (S)-Glycerate
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB06372
is: SBO:0000247
constant: false
type: Species
is: CHEBI:33871
initial amount: NaN

metaR NACHEX13ly
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110008#
is: SBO:0000176
reactant: MODEL1310110008#
fast: false
product: MODEL1310110008#

metaR RIBt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110008#
name: ribose transport via diffusion
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110008#
reversible: true
product: MODEL1310110008#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_78769c64_2f22_4d1e_bf2f_2daefdabd735
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q59EH3
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:52
initial amount: NaN
name: ACP1

http://identifiers.org/biomodels.db/MODEL1310110008#_3ca68e56_c97b_4037_8cf8_f174e3991f92
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:84720
name: PIGO
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaR PCRNtm
name: transport into the mitochondria from cytosol (carnitine)
reactant: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
product: MODEL1310110008#
is: SBO:0000185

metaR r1561
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110008#
is: SBO:0000185
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110008#

metaM ppa c
is: HMDB00237
name: propionate
has only substance units: false
type: Species
is: CHEBI:17272
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163

metaM 2mop c
constant: false
has only substance units: false
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: HMDB01172
name: 2-methyl-3-oxopropanoate
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57700
boundary condition: false

metaR FAOXC164C165m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_1f60ac8c_2a80_411e_9672_d74a8d9f2b29
initial concentration: NaN
is encoded by: hsa:80025
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: PANK2
is: Q9BZ23

metaR FUCASEe
type: Reaction
is: SBO:0000176
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.2.1.51
is described by: ECO:0000000
kinetic law: MODEL1310110008#
name: alpha-fucosidase, extracellular
reversible: false
reactant: MODEL1310110008#
modifier: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD

metaR CITRtm
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110008#
reactant: MODEL1310110008#
name: citrulline mitochondrial transport via proton antiport

http://identifiers.org/biomodels.db/MODEL1310110008#_b3600d8d_a94b_4b0d_ac84_83b7791063e8
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6785
has only substance units: false
constant: false
is: Q9GZR5
type: Species
name: ELOVL4

metaM msa m
is: HMDB11111
type: Species
constant: false
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:33190
name: 3-oxopropanoate
is: SBO:0000247

metaR ADSS
fast: false
kinetic law: MODEL1310110008#
name: adenylosuccinate synthase
is version of: http://identifiers.org/ec-code/6.3.4.4
is: SBO:0000176
modifier: MODEL1310110008#
is described by: ECO:0000134
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
product: MODEL1310110008#
reversible: false
type: Reaction

metaR PAIL4P HStn
is: SBO:0000185
product: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
reactant: MODEL1310110008#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_ffd45a9a_c9fc_402a_82ee_b0992c729c74
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:10678
name: B3GNT2
constant: false
is: SBO:0000252
initial concentration: NaN

metaM ksi pre7 g
initial amount: NaN
constant: false
is: CHEBI:58053
is: C00130
name: keratan sulfate I biosynthesis, precursor 7
is: HMDB00175
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C115H187N8O85SX CHARGE: -2
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_b4e7e91c_8f31_46de_bc0c_06c0582cbef6
name: ST3GAL1
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6482
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaR EX CE5869 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lysyl-proline exchange
type: Reaction

metaR COt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
kinetic law: MODEL1310110008#
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110008#
name: CO transporter via diffusion
product: MODEL1310110008#
fast: false

metaR r1467
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110008#
reactant: MODEL1310110008#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110008#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110008#_e4719269_a0fb_4e7f_934c_567078e0865e
is encoded by: hsa:80270
is: SBO:0000252
constant: false
boundary condition: true
is: Q9H2F3
initial amount: NaN
type: Species
name: HSD3B7
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_5a41abb7_068e_4c09_b525_6080e13726a4
constant: false
is: P17568
initial amount: NaN
has only substance units: false
is encoded by: hsa:4713
initial concentration: NaN
type: Species
is: SBO:0000252
name: NDUFB7
boundary condition: true

metaR NH4tp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110008#
fast: false
name: ammonia peroxisomal transport
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110008#_4d6dd36c_b267_4e4c_9f6a_6d41cb050217
is: SBO:0000252
constant: false
type: Species
boundary condition: true
is encoded by: hsa:D87002
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: _D87002_1_m

metaM dgsn c
is: C00330
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
constant: false
is: CHEBI:17172
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: Deoxyguanosine
is: HMDB00085
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_e4dc7cfe_9613_46a9_bc54_bb1f0e2e5aa2
constant: false
initial concentration: NaN
boundary condition: true
is: O60488
is encoded by: hsa:2182
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
name: ACSL4

http://identifiers.org/biomodels.db/MODEL1310110008#_94963dca_96a1_4e54_9e17_6275775a353f
type: Species
initial amount: NaN
name: AK3
is: SBO:0000252
initial concentration: NaN
is: E7ET30
is encoded by: hsa:50808
boundary condition: true
has only substance units: false
constant: false

metaR r0627
fast: false
is described by: ECO:0000000
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_a254b77e_0cb9_47bf_8b49_b2c5aba7fb6b
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:9123
is: O15427
is: SBO:0000252
constant: false
type: Species
has only substance units: false
name: SLC16A3

metaR CSAPASEly
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110008#
product: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
type: Reaction
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)
reversible: false

metaR r0779
product: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
reactant: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110008#_36728048_3ed3_44a4_b35a_747b719f9af1
boundary condition: true
name: PLCD3
is: Q8N3E9
type: Species
is encoded by: hsa:113026
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110008#_9209b240_0a37_4310_9e82_8f0119223d46
is encoded by: hsa:57127
is: Q9H310
initial amount: NaN
initial concentration: NaN
name: RHBG
constant: false
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false

metaR EX strch2 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_27280bf6_9b4d_4b8e_a6a8_2453cb5e5152
is encoded by: hsa:1738
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
constant: false
name: DLD
is: P09622

http://identifiers.org/biomodels.db/MODEL1310110008#_b0d16185_c8c6_47ea_8e96_ba927ec48e59
is: P51160
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:5146
constant: false
name: PDE6C
initial amount: NaN
has only substance units: false

metaM arachdcrn m
boundary condition: false
is: CHEBI:57387
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
name: C20:4 carnitine
is: HMDB01322

metaR r0365
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
kinetic law: MODEL1310110008#
is: SBO:0000176
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
product: MODEL1310110008#
reversible: false
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.3.1.72
modifier: MODEL1310110008#

metaR LEUGLYHYc
reversible: true
kinetic law: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
is described by: ECO:0000134
is: SBO:0000176
name: hydrolysis of leucylglycine
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_6d96b6d5_88d1_4775_8bfe_fbba9a0b0ef9
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:9843
initial amount: NaN
has only substance units: false
type: Species
name: HEPH
boundary condition: true
is: E9PHN8

http://identifiers.org/biomodels.db/MODEL1310110008#_e9997577_2804_4c87_929e_7099548df6ac
is: E9PDK1
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: SLC4A9
is encoded by: hsa:83697
is: SBO:0000252
boundary condition: true
constant: false

metaM hpdcacoa c
type: Species
initial amount: NaN
boundary condition: false
name: heptadecanoyl coa
is: SBO:0000247
has only substance units: false
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
is: HMDB06497
initial concentration: 1.0
constant: false

metaM dmnoncrn m
has only substance units: false
constant: false
name: 4,8 dimethylnonanoyl carnitine
is: SBO:0000247
boundary condition: false
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
is: HMDB06202
initial concentration: 1.0
initial amount: NaN
type: Species

metaM h2o x
type: Species
name: H2O
is: CHEBI:15377
initial concentration: 1.0
is: C00001
constant: false
is: HMDB02111
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR GUAPRT
type: Reaction
reactant: MODEL1310110008#
modifier: MODEL1310110008#
name: guanine phosphoribosyltransferase
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
reversible: false
is version of: http://identifiers.org/ec-code/2.4.2.8
fast: false

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaM tettet6 c
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB06246
constant: false
name: tetracosatetraenoic acid n-6
type: Species
initial concentration: 1.0
boundary condition: false

metaR RE2079R
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
is: SBO:0000176
name: RE2079
kinetic law: MODEL1310110008#
is described by: ECO:0000000
reactant: MODEL1310110008#
product: MODEL1310110008#
reversible: true
type: Reaction

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaM dolp U r
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57683
name: dolichyl phosphate(2-)
boundary condition: false
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110

metaR CDSm
type: Reaction
reversible: false
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
name: phosphatidate cytidylyltransferase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.41

http://identifiers.org/biomodels.db/MODEL1310110008#_463d4f01_73b0_4338_a721_efbf63735df1
has only substance units: false
type: Species
is: SBO:0000252
name: ELOVL2
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:54898
is: Q9NXB9
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_a016cd9f_88bd_468d_8176_d224d0e31339
initial concentration: NaN
is: SBO:0000297
has part: P07327
has only substance units: false
boundary condition: true
name: ADH1A:ADH1B
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:124

http://identifiers.org/biomodels.db/MODEL1310110008#_bf3bb2bc_8525_4320_8008_37d6aae2fb79
initial concentration: NaN
is encoded by: hsa:4191
initial amount: NaN
name: MDH2
has only substance units: false
constant: false
is: P40926
is: SBO:0000252
boundary condition: true
type: Species

metaR ECOAH1m
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
fast: false
is: SBO:0000176
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/4.2.1.18
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
product: MODEL1310110008#
is described by: ECO:0000304
reversible: true

metaR AG13T11g
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110008#
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110008#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110008#_80a1f333_20ff_4584_905d_50bff4820f79
initial concentration: NaN
is encoded by: hsa:10195
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: ALG3
is: Q92685

metaR DUMPtn
is: SBO:0000185
type: Reaction
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: dUMP nuclear transport
fast: false
product: MODEL1310110008#
is described by: ECO:0000000
kinetic law: MODEL1310110008#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110008#_1181fec3_8f11_4230_b098_b8a2797de98f
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: DDO
constant: false
is encoded by: hsa:8528
initial concentration: NaN
type: Species
is: Q99489

http://identifiers.org/biomodels.db/MODEL1310110008#_6cb4c384_7ac0_454a_9e17_316139001f8b
initial concentration: NaN
is encoded by: hsa:U52111
name: _U52111_1_c
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_316bde3c_1311_45eb_a0da_b91bba565963
name: ATP5G3
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:518
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110008#_705d466d_cfe5_48d9_aa7f_dda487a8f906
name: _H77542_1_c
initial amount: NaN
constant: false
is encoded by: hsa:H77542
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252

metaR DTTPtn
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
kinetic law: MODEL1310110008#
name: dTTP diffusion in nucleus
type: Reaction
product: MODEL1310110008#

metaR LNLCt
reversible: true
type: Reaction
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000000
name: Linoleic acid (n-C18:2) transport in via diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
product: MODEL1310110008#

metaM nicrnt c
is: SBO:0000247
has only substance units: false
is: CHEBI:57502
name: Nicotinate D-ribonucleotide
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
type: Species
is: C01185
is: HMDB01132
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_c1282852_3554_4f91_88cc_f907a77924b1
initial concentration: NaN
is encoded by: hsa:1629
type: Species
has only substance units: false
has part: P21953
is: SBO:0000297
name: DBT:DLD:BCKDHA:BCKDHB
initial amount: NaN
is encoded by: hsa:593
is encoded by: hsa:594
has part: B4DP47
boundary condition: true
constant: false
has part: P11182

metaM val L m
boundary condition: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
has only substance units: false
is: CHEBI:16414
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: HMDB00883
name: L-valine
initial amount: NaN

metaM docohexcoa x
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: 2,4,7,10,13,16-docosahexenoylcoa
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN
type: Species
is: SBO:0000247
constant: false

metaR MMMm
is version of: http://identifiers.org/ec-code/5.4.99.2
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
is: SBO:0000176
kinetic law: MODEL1310110008#
name: methylmalonyl-CoA mutase
reversible: true
fast: false
modifier: MODEL1310110008#
is described by: ECO:0000269
product: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction

metaR EX tdcrn
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for myristoyl carnitine
type: Reaction

metaM gmp e
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:58115
name: GMP(3-)
initial concentration: 1.0
is: HMDB01397
boundary condition: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: SBO:0000247

metaM dcholcoa r
name: chenodeoxycholoyl coenzyme a
is: CHEBI:28701
initial amount: NaN
is: SBO:0000247
is: HMDB06292
has only substance units: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
boundary condition: false
constant: false
type: Species
initial concentration: 1.0

metaM man c
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: HMDB00169
name: D-Mannose
boundary condition: false
initial concentration: 1.0
is: C00159
is: CHEBI:16024

http://identifiers.org/biomodels.db/MODEL1310110008#_a77a4354_543a_4429_bb2e_adc33fa92401
type: Species
is: Q3MHC9
constant: false
name: SKIV2L2
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:23517
has only substance units: false

metaR GPIMTer L
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
reversible: false
modifier: MODEL1310110008#
is: SBO:0000176
reactant: MODEL1310110008#
product: MODEL1310110008#
fast: false
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
type: Reaction
kinetic law: MODEL1310110008#
is described by: ECO:0000000

metaR r0911
name: Facilitated diffusion
reactant: MODEL1310110008#
is described by: ECO:0000000
kinetic law: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
product: MODEL1310110008#
is: SBO:0000185
fast: false
reversible: true

metaM sbcoa x
name: suberylcoa
boundary condition: false
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
is: http://identifiers.org/pubchem.compound/16019966
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR GNDer
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
is described by: ECO:0000000
product: MODEL1310110008#
type: Reaction
fast: false
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
name: phosphogluconate dehydrogenase, endoplasmic reticulum
is: SBO:0000176

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_78cab5fe_b3d8_4388_bd2f_63c079fbe410
is: Q9P1E4
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
name: MAN2A2
is encoded by: hsa:4122
has only substance units: false

metaM c12dccoa c
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
boundary condition: false
initial amount: NaN
name: dodecanedioylcoa
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00623
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_c4d3da9b_47a3_4143_954b_843455163449
boundary condition: true
name: GALNT2
has only substance units: false
is encoded by: hsa:2590
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
is: Q10471

metaM 6pgc r
is: HMDB01316
name: 6-phosphonatooxy-D-gluconate
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:58759

metaR RE1531M
reactant: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1531
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR FAOXC184m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_f7c0f5cd_6065_4c21_9241_68d5ac5ce74d
is: A8K761
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4716
name: NDUFB10

metaR FAOXC2442246x
is described by: ECO:0000269
fast: false
reactant: MODEL1310110008#
reversible: false
product: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c24:4,n-6 -> c22:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/4.2.1.107
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110008#

metaR GLYC3PFADm
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
reversible: false
product: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000176
kinetic law: MODEL1310110008#
type: Reaction
name: glycerophosphate shuttle for trasnfer of reducing equivalents
fast: false

metaR CERT1rt
is version of: http://identifiers.org/ec-code/2.7.11.1
name: ceramide transport protein
type: Reaction
modifier: MODEL1310110008#
fast: false
product: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000304
reactant: MODEL1310110008#
reversible: true
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide

metaM glyc S c
constant: false
boundary condition: false
is: SBO:0000247
name: (S)-Glycerate
is: HMDB06372
has only substance units: false
is: CHEBI:33871
notes: FORMULA: C3H5O4 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
type: Species

metaR r0360
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110008#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is: SBO:0000176
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/6.2.1.16
kinetic law: MODEL1310110008#
reversible: false
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reactant: MODEL1310110008#

metaM dgsn e
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00085
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
name: Deoxyguanosine
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: C00330
is: CHEBI:17172

metaR C142ACBP
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradeca dienoyl coa from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_d2d73053_38c2_4596_a567_e5c05d2c3a24
constant: false
is encoded by: hsa:117248
name: GALNTL2
initial amount: NaN
is: SBO:0000252
is: Q8N3T1
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN

metaM gmp c
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
is: CHEBI:58115
is: C00144
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
name: GMP
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB01397

metaR r0774
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
modifier: MODEL1310110008#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000
reactant: MODEL1310110008#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37

metaM hs deg2 l
is: HMDB01352
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:17180
has only substance units: false
name: heparan sulfate, degradation product 2
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_33bf5105_2270_4ec0_8baf_62e95dc46a0f
has only substance units: false
type: Species
name: SLC25A15
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:10166
is: Q9Y619
is: SBO:0000252
initial concentration: NaN

metaM CE5120 m
boundary condition: false
name: trans-2-cis-8-tetradecadienoyl-CoA
initial concentration: 1.0
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
is: CHEBI:57923
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaM c226coa x
is: http://identifiers.org/pubchem.compound/47205479
name: cervonyl coenzyme A
is: C16169
constant: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR r0629
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is: SBO:0000176
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.6.1.22
is version of: http://identifiers.org/ec-code/3.1.4.1
reversible: true
modifier: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_ee33abe0_d80f_4baa_93a3_dd589463cdd0
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:AGPAT7
initial amount: NaN
boundary condition: true
name: _AGPAT7_1_c
initial concentration: NaN

metaR GLYK
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.30
modifier: MODEL1310110008#
product: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
name: glycerol kinase
reactant: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (2710.2) or (2712.1) or (2710.1) or (2713.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269

metaR FAS80COA L
modifier: MODEL1310110008#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110008#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
product: MODEL1310110008#
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
fast: false
reactant: MODEL1310110008#
is: SBO:0000176

metaM 3ddcrn c
notes: FORMULA: C19H37NO5 CHARGE: 0
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
name: 3-hydroxydodecanoylcarnitine
is: HMDB00623
initial amount: NaN
constant: false
initial concentration: 1.0

metaR r2538
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110008#
is: SBO:0000185
product: MODEL1310110008#
is described by: ECO:0000000
fast: false
name: Utilized transport
reversible: true
reactant: MODEL1310110008#

metaM ksi deg25 l
is: SBO:0000247
type: Species
has only substance units: false
name: keratan sulfate I, degradation product 25
is: CHEBI:57455
initial concentration: 1.0
is: HMDB01354
constant: false
notes: FORMULA: C118H192N8O98S4 CHARGE: -4
initial amount: NaN
boundary condition: false

metaR FTCD
fast: false
reversible: false
name: formimidoyltransferase cyclodeaminase
reactant: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
is: SBO:0000176
kinetic law: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.1.2.5
is described by: ECO:0000134

metaR FAS140COA
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
fast: false
is described by: ECO:0000269
modifier: MODEL1310110008#
reactant: MODEL1310110008#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110008#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
name: fatty-acyl-CoA synthase (n-C14:0CoA)

metaM h2o r
initial amount: NaN
has only substance units: false
is: C00001
type: Species
name: H2O
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB02111
initial concentration: 1.0
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

metaM n2m2nm l
has only substance units: false
notes: FORMULA: C58H97N5O41 CHARGE: 0
boundary condition: false
initial amount: NaN
name: n2m2nmasn (w/o peptide linkage)
constant: false
is: HMDB00573
is: SBO:0000247
type: Species
is: CHEBI:30825
initial concentration: 1.0

metaR EX sl L LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-sulfolactate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_95601d25_c6b9_45d2_a55c_380bb3221227
name: SLC40A1
is: SBO:0000252
is: Q9NP59
has only substance units: false
boundary condition: true
is encoded by: hsa:30061
initial concentration: NaN
type: Species
constant: false
initial amount: NaN

metaM arachdcrn c
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01322
name: C20:4 carnitine
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:57387
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_2dd5462c_a00f_4c92_b290_6a3f8d0b85ad
initial concentration: NaN
is encoded by: hsa:5332
boundary condition: true
has only substance units: false
initial amount: NaN
name: PLCB4
is: SBO:0000252
is: Q15147
constant: false
type: Species

metaM dmnoncrn c
notes: FORMULA: C18H37NO4 CHARGE: 0
name: 4,8-dimethylnonanoyl carnitine
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB06202
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false

metaR CLPNDt
reversible: true
fast: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
product: MODEL1310110008#

metaM utp m
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: UTP(4-)
is: HMDB00285
is: CHEBI:46398
type: Species
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075

http://identifiers.org/biomodels.db/MODEL1310110008#_01295f12_392d_45dd_9c68_65fe8ca172f7
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: Q86V21
name: AACS
is encoded by: hsa:65985
initial concentration: NaN
is: SBO:0000252

metaR ADSK
is described by: ECO:0000269
type: Reaction
reversible: false
name: adenylyl-sulfate kinase
fast: false
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
product: MODEL1310110008#
is: SBO:0000176
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.1.25
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_d7b421a1_cbda_4082_971a_74784846e698
has only substance units: false
initial amount: NaN
name: DGKH
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:160851
is: A8K0I1
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_46f4765e_6629_40ed_9fb2_7b7ac1723fc8
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8706
type: Species
initial amount: NaN
constant: false
is: O75752
has only substance units: false
name: B3GALNT1

metaR r2539
type: Reaction
fast: false
name: Postulated transport reaction
is described by: ECO:0000000
kinetic law: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110008#

metaM 3ddcrn e
is: SBO:0000247
notes: FORMULA: C19H37NO5 CHARGE: 0
is: HMDB00791
boundary condition: false
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: C02838
name: 3-hydroxydodecanoylcarnitine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_c7df2f8e_b6ee_498a_86d6_073db26a347b
has only substance units: false
name: CPT1B
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
is: E9PCP2
is encoded by: hsa:1375

metaR APOCFm
fast: false
kinetic law: MODEL1310110008#
is: SBO:0000176
reversible: false
reactant: MODEL1310110008#
product: MODEL1310110008#
name: Apocarboxylase formation, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_b3bd5a1e_1ba4_4484_bbaf_ab6320920d0f
initial amount: NaN
type: Species
boundary condition: true
is: A5JJ20
initial concentration: NaN
name: SLC4A4
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:8671

metaM pyr x
is: CHEBI:15361
is: C00022
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
initial concentration: 1.0
is: HMDB00243
name: pyruvate
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3324
has only substance units: false
constant: false
type: Species

metaM man g
type: Species
is: SBO:0000247
name: D-mannose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: CHEBI:16024
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00169
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_396c8f66_c22c_4cbf_84d2_acb8a40d320a
initial concentration: NaN
is: Q9NRX3
constant: false
boundary condition: true
is: SBO:0000252
type: Species
name: NDUFA4L2
initial amount: NaN
has only substance units: false
is encoded by: hsa:56901

http://identifiers.org/biomodels.db/MODEL1310110008#_345430c3_8eb8_4534_a3a5_39b4eb6b8a97
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:1716
boundary condition: true
is: E5KSL5
name: DGUOK
is: SBO:0000252
initial amount: NaN

metaR RE3624M
type: Reaction
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: false
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE3624
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reactant: MODEL1310110008#

metaR S3TASE1ly
reactant: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
name: N-acetylglucosamine-3-sulfatase, lysosomal
kinetic law: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
reversible: true
is: SBO:0000176

metaR r1148
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
is described by: ECO:0000000
name: Active transport
type: Reaction
fast: false
kinetic law: MODEL1310110008#
is: SBO:0000185
product: MODEL1310110008#

metaM utp n
is: HMDB00285
has only substance units: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: CHEBI:46398
initial concentration: 1.0
name: UTP(4-)
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
boundary condition: false

metaR S6TASE21ly
product: MODEL1310110008#
modifier: MODEL1310110008#
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110008#_dee3ecec_7427_47b9_8f46_0f9e68f8890c
name: SLC25A12
is: O75746
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8604
initial amount: NaN
type: Species

metaM val L c
constant: false
is: CHEBI:16414
name: L-valine
is: HMDB00883
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_4886c629_7734_45d8_8715_ef23b9c1ad6a
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:5144
type: Species
name: PDE4D
has only substance units: false
boundary condition: true
is: Q08499
is: SBO:0000252

metaM fmn c
type: Species
is: SBO:0000247
constant: false
is: HMDB01520
is: CHEBI:58210
initial concentration: 1.0
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
is: C00061
name: FMN
initial amount: NaN
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_e29d2aa2_25f5_4082_bf40_6335a339ac76
constant: false
is: SBO:0000252
type: Species
name: HMOX1
is: Q6FH11
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:3162

http://identifiers.org/biomodels.db/MODEL1310110008#_7f33bbce_9c0d_4192_9d83_ce994d7abc50
constant: false
name: PDE6G
initial amount: NaN
is: P18545
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5148
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_58ec09f3_036c_49b2_a0eb_8addb828617f
initial amount: NaN
is encoded by: hsa:27124
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species
name: INPP5J

metaR FAOXC12DCx
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanedioyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_b348219b_7008_4297_91c9_826a70890d68
name: CA12
is encoded by: hsa:771
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_8504124f_206d_4a35_8ec2_352bd1f105d1
name: ADCY5
boundary condition: true
is encoded by: hsa:111
is: O95622
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
type: Species
initial amount: NaN

metaR GLCAASE7ly
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.31
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
product: MODEL1310110008#
type: Reaction
reversible: false
name: beta-glucuronidase, lysosomal
is: SBO:0000176
fast: false

metaR r2130
product: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR SEBACACT
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of sebacic acidd
type: Reaction

metaR r2537
is: SBO:0000185
reactant: MODEL1310110008#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110008#
name: Utilized transport
product: MODEL1310110008#
is described by: ECO:0000000
reversible: true

metaR AG13T8g
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_7b0dda17_f47c_4376_9d78_2f2426237ac1
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:175
name: AGA
initial amount: NaN
constant: false
boundary condition: true
is: P20933
is: SBO:0000252

metaM lald L c
boundary condition: false
is: SBO:0000247
name: (S)-lactaldehyde
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
constant: false
is: HMDB03052
type: Species
has only substance units: false
is: CHEBI:18041

metaR RE1520M
modifier: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
type: Reaction
name: RE1520
reactant: MODEL1310110008#
fast: false

metaR DOLP Uter
product: MODEL1310110008#
reactant: MODEL1310110008#
name: dolichol phosphate flippase (uterus)
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_51dfbb33_d74e_4771_8978_e37d47725536
initial amount: NaN
name: PYCRL
has only substance units: false
is: SBO:0000252
is: Q53H96
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:65263
boundary condition: true

metaR r2131
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110008#
is: SBO:0000185
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110008#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110008#

metaR RE2659R
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
product: MODEL1310110008#
is: SBO:0000176
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
name: RE2659

metaR r2092
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110008#
type: Reaction
is: SBO:0000185
product: MODEL1310110008#
reversible: true
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
fast: false
is described by: ECO:0000000

metaM fmn e
is: HMDB01520
boundary condition: false
has only substance units: false
is: CHEBI:58210
is: SBO:0000247
is: C00061
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C17H19N4O9P CHARGE: -2
name: FMN
type: Species
constant: false

metaM btcoa c
type: Species
initial amount: NaN
is: C00136
is: CHEBI:57371
name: Butanoyl-CoA
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
boundary condition: false
is: HMDB01088
constant: false
has only substance units: false

metaM h2o n
is: SBO:0000247
type: Species
is: HMDB02111
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
name: water
boundary condition: false
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

metaM 3aib D c
boundary condition: false
is: C03265
constant: false
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
initial concentration: 1.0
is: HMDB02299
type: Species
name: D-3-Amino-isobutanoate
initial amount: NaN
is: SBO:0000247

metaM val L e
is: HMDB00883
is: CHEBI:16414
type: Species
initial concentration: 1.0
name: L-valine
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
has only substance units: false
boundary condition: false
constant: false

metaR r2534
product: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true

metaM ksi pre33 g
constant: false
type: Species
is: C00130
name: keratan sulfate I biosynthesis, precursor 33
is: SBO:0000247
is: CHEBI:58053
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
boundary condition: false
has only substance units: false
is: HMDB00175
initial concentration: 1.0
initial amount: NaN

metaR G14T21g
reversible: false
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110008#
type: Reaction
fast: false
kinetic law: MODEL1310110008#
is: SBO:0000176

metaM hpdcacoa m
boundary condition: false
is: HMDB06497
initial concentration: 1.0
is: SBO:0000247
name: heptadecanoyl coa
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
constant: false

metaR r2132
type: Reaction
is described by: ECO:0000000
fast: false
modifier: MODEL1310110008#
product: MODEL1310110008#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110008#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110008#_d936b540_fb64_46ea_b387_d0b41fb36d92
is: Q5HYI4
is encoded by: hsa:6713
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
name: SQLE
type: Species
constant: false
is: SBO:0000252

metaR PI45PLC
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000176
product: MODEL1310110008#
reversible: false
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.11

metaR r1464
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110008#
is: SBO:0000185
reversible: true
name: Active transport

http://identifiers.org/biomodels.db/MODEL1310110008#_500ba308_a26a_4f2f_bc29_6c9494fdb6a9
is: SBO:0000252
name: A4GALT
initial concentration: NaN
constant: false
is encoded by: hsa:53947
boundary condition: true
initial amount: NaN
is: Q9NPC4
has only substance units: false
type: Species

metaM man l
is: CHEBI:16024
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false
is: SBO:0000247
has only substance units: false
name: D-mannose
type: Species
is: HMDB00169

metaM thmpp c
initial amount: NaN
name: Thiamine diphosphate
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:45931
has only substance units: false
is: HMDB01372
type: Species
constant: false
boundary condition: false
is: C00068

metaR FAOXC181C161m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C16:1)m
type: Reaction

metaR r2093
type: Reaction
modifier: MODEL1310110008#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110008#

metaM h2o m
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: C00001
boundary condition: false
name: H2O
has only substance units: false
is: CHEBI:15377
is: SBO:0000247

metaR r2535
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_b1cea354_bb29_4cd0_abd8_8fc520392015
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is: O14734
initial amount: NaN
boundary condition: true
name: ACOT8
is encoded by: hsa:10005

http://identifiers.org/biomodels.db/MODEL1310110008#_1281a634_9464_41b1_b07a_03b645329f9e
is: SBO:0000252
name: _N63787_1_c
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:N63787
boundary condition: true
constant: false

metaM ksii core4 pre7 g
name: keratan sulfate II biosynthesis, precursor 7
constant: false
notes: FORMULA: C75H121N6O56SX CHARGE: -2
is: SBO:0000247
has only substance units: false
is: CHEBI:58053
is: HMDB00175
initial concentration: 1.0
is: C00130
initial amount: NaN
boundary condition: false
type: Species

metaR r2133
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110008#
reactant: MODEL1310110008#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110008#
product: MODEL1310110008#

metaM c8dc c
boundary condition: false
is: HMDB00791
initial amount: NaN
notes: FORMULA: C15H26NO6 CHARGE: -1
initial concentration: 1.0
constant: false
is: C02838
has only substance units: false
type: Species
name: suberyl carnitine
is: SBO:0000247

metaR GALASE3ly
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
kinetic law: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
modifier: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR r1144
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10823827 NOTES:
is: SBO:0000185
product: MODEL1310110008#
is described by: ECO:0000000
reactant: MODEL1310110008#
reversible: false
name: Major Facilitator(MFS) TCDB:2.A.18.6.3
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_ae381750_bff0_41e5_aa83_f7b44805599a
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:4724
boundary condition: true
is: O43181
initial concentration: NaN
name: NDUFS4

metaM tettet6 e
has only substance units: false
name: tetracosatetraenoic acid n-6
initial amount: NaN
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
boundary condition: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB06246

metaM lnlccrn m
boundary condition: false
name: Linoleyl carnitine
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB06469
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110008#_9923c073_1336_4630_981f_20c27d4e2269
is: SBO:0000252
name: GPX5
type: Species
constant: false
has only substance units: false
is encoded by: hsa:2880
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: O75715

http://identifiers.org/biomodels.db/MODEL1310110008#_4b2dd46b_22fc_48e2_b1f0_fba72cfb48cd
initial amount: NaN
name: B3GNT1
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:11041
initial concentration: NaN
is: O43505
is: SBO:0000252

metaR r2532
reactant: MODEL1310110008#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110008#
is: SBO:0000185
product: MODEL1310110008#

metaR PROSTGF2t
reactant: MODEL1310110008#
is: SBO:0000185
kinetic law: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
fast: false
name: prostaglandin uniport

metaR r2090
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000000
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110008#
modifier: MODEL1310110008#

metaM h2o l
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB02111
name: water
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

metaR EX elaid LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: elaidic acid exchange
type: Reaction

metaR FAOXC8C6x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_877db212_f430_40da_b9a7_6a975921fcf1
is encoded by: hsa:498
is encoded by: hsa:509
initial concentration: NaN
type: Species
has part: P25705
boundary condition: true
is: SBO:0000297
initial amount: NaN
constant: false
has part: Q6I9V2
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
has only substance units: false

metaM hs deg13 l
has only substance units: false
constant: false
name: heparan sulfate, degradation product 13
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:17180
is: HMDB01352
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_dae4cddf_bbb2_476e_8474_c1dd3f220b7f
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: SLC43A2
constant: false
is encoded by: hsa:124935
is: Q8N370

metaM ha pre1 l
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:16126
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
name: hyaluronan biosynthesis, precursor 1
is: SBO:0000247
constant: false

metaM ksii core2 pre7 g
name: keratan sulfate II biosynthesis, precursor 7
has only substance units: false
is: HMDB00175
boundary condition: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C67H108N5O51SX CHARGE: -2
is: CHEBI:58053
initial concentration: 1.0
is: SBO:0000247
is: C00130

metaM CE4790 m
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
boundary condition: false
is: CHEBI:57923

metaR r1147
product: MODEL1310110008#
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_b5065c86_357f_4213_b9d4_66f27e74ad1b
name: ALAD
is encoded by: hsa:210
is: P13716
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false

metaM 4hphac e
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
type: Species
initial concentration: 1.0
constant: false
is: HMDB00020
name: 4-hydroxyphenylacetate
is: CHEBI:48999
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR r1466
is described by: ECO:0000000
type: Reaction
name: EC:2.3.1.86
reversible: true
reactant: MODEL1310110008#
is: SBO:0000176
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110008#
fast: false

metaR FE3MTP1
modifier: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000134
reversible: false
name: transport of ferrous iron into blood
fast: false
product: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:

metaR PPItm
reversible: true
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
fast: false
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110008#
type: Reaction
name: diphopshate transporter, mitochondrial
reactant: MODEL1310110008#

metaR FALDH
modifier: MODEL1310110008#
type: Reaction
name: formaldehyde dehydrogenase
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
reversible: true
reactant: MODEL1310110008#
is: SBO:0000176
fast: false

metaM fpram c
constant: false
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58478
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
has only substance units: false
type: Species
boundary condition: false
is: C04640
initial amount: NaN
is: HMDB06211

http://identifiers.org/biomodels.db/MODEL1310110008#_62dd4449_4cab_4f7b_8334_f0520bb8034f
constant: false
name: LTA4H
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is: P09960
is encoded by: hsa:4048
initial concentration: NaN

metaR r2091
type: Reaction
product: MODEL1310110008#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110008#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110008#

metaR HEXCOAACBP
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexanoyl-CoA (n-C6:0CoA) from mitochondria into cytosol
type: Reaction

metaM clpndcoa c
is: http://identifiers.org/pubchem.compound/47205476
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
constant: false
is: SBO:0000247
type: Species
boundary condition: false
name: clupanodonyl CoA
has only substance units: false
initial amount: NaN
is: C16166
initial concentration: 1.0
is: HMDB06267

http://identifiers.org/biomodels.db/MODEL1310110008#_1ab59eb7_b4cb_4521_a634_61ed48db7938
is encoded by: hsa:11212
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
name: PROSC
is: SBO:0000252
is: O94903

metaM xoldioloneh c
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
constant: false
is: CHEBI:2288
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB06887
type: Species

metaM dcholcoa x
boundary condition: false
has only substance units: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
name: chenodeoxycholoyl coenzyme a
initial amount: NaN
is: HMDB06292
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:28701
is: SBO:0000247

metaM docohexcoa m
name: 2,4,7,10,13,16-docosahexenoylcoa
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
type: Species
boundary condition: false
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN

metaR DALAt2r
reversible: true
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
type: Reaction
modifier: MODEL1310110008#
fast: false
name: D-alanine transport via proton symport
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000304

metaM dgsn m
has only substance units: false
type: Species
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:17172
boundary condition: false
name: Deoxyguanosine
is: C00330
initial concentration: 1.0
is: HMDB00085

metaR CO2ter
reactant: MODEL1310110008#
product: MODEL1310110008#
name: CO2 endoplasmic reticular transport via diffusion
kinetic law: MODEL1310110008#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

metaM c12dc x
notes: FORMULA: C19H34NO6 CHARGE: -1
initial concentration: 1.0
type: Species
is: C05279
boundary condition: false
constant: false
name: dodecanedioyl carnitine
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB11123

http://identifiers.org/biomodels.db/MODEL1310110008#_45e6a888_8e82_4cef_9197_677ce0259f69
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8704
name: B4GALT2
type: Species

metaM cs b deg1 l
is: CHEBI:57455
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
initial concentration: 1.0
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
initial amount: NaN
is: SBO:0000247
is: HMDB01354
boundary condition: false
constant: false
type: Species
has only substance units: false

metaR r2098
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction
modifier: MODEL1310110008#
is described by: ECO:0000000
reversible: true
product: MODEL1310110008#
fast: false

metaR r2125
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110008#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110008#
reversible: true
reactant: MODEL1310110008#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110008#

metaM c226coa m
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: cervonyl coenzyme A
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205479
initial amount: NaN
is: C16169

metaR r0908
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
name: Postulated transport reaction
reversible: true
reactant: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
fast: false

metaR ADPCOACROT
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoyl carnitine
type: Reaction

metaR PPNCL3
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.2.5
kinetic law: MODEL1310110008#
name: phosphopantothenate-cysteine ligase
product: MODEL1310110008#
type: Reaction
fast: false
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110008#
modifier: MODEL1310110008#

metaR SEBCOACROT
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

metaR CHOLtn
name: Choline transport, nuclear through pores
is described by: ECO:0000000
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
is: SBO:0000185
product: MODEL1310110008#

metaR PUNP5
fast: false
modifier: MODEL1310110008#
is described by: ECO:0000269
kinetic law: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
name: purine-nucleoside phosphorylase (Inosine)
is: SBO:0000176
reactant: MODEL1310110008#
reversible: true
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.2.1

metaR S6TASE16ly
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110008#
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true

metaM 4hphac c
has only substance units: false
name: 4-hydroxyphenylacetate
is: CHEBI:48999
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
constant: false
is: HMDB00020
initial concentration: 1.0
is: SBO:0000247

metaM co2 e
type: Species
is: HMDB01967
constant: false
has only substance units: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: SBO:0000247
is: CHEBI:16526
is: C00011
boundary condition: false
initial concentration: 1.0
name: CO2
initial amount: NaN

metaM cmp e
type: Species
constant: false
has only substance units: false
is: HMDB00095
is: CHEBI:60377
is: SBO:0000247
name: CMP(2-)
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM ksi deg41 l
boundary condition: false
initial concentration: 1.0
is: HMDB00143
name: keratan sulfate I, degradation product 41
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:12936
is: SBO:0000247
type: Species
notes: FORMULA: C34H58N2O26 CHARGE: 0

metaM cgly e
boundary condition: false
type: Species
is: HMDB00078
initial amount: NaN
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
name: L-cysteinylglycine
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:4047
is: SBO:0000247

metaM tcynt m
initial amount: NaN
is: CHEBI:18022
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
type: Species
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB01453
initial concentration: 1.0
name: thiocyanate

metaR r2124
modifier: MODEL1310110008#
reversible: true
reactant: MODEL1310110008#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
product: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

metaM 3oddcoa x
is: HMDB03937
constant: false
is: SBO:0000247
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
type: Species
initial concentration: 1.0
has only substance units: false
name: 3-Oxododecanoyl-CoA
boundary condition: false
initial amount: NaN
is: CHEBI:27868

metaR M1316Mg
type: Reaction
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.114
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
reversible: false
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
product: MODEL1310110008#

metaM 56dura c
constant: false
is: CHEBI:15901
initial concentration: 1.0
boundary condition: false
name: 5,6-dihydrouracil
initial amount: NaN
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
is: HMDB00076
type: Species
is: SBO:0000247
has only substance units: false

metaR r2097
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reversible: true
product: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#

metaM core6 g
has only substance units: false
is: CHEBI:16478
type: Species
is: SBO:0000247
notes: FORMULA: C16H27N2O10X CHARGE: 0
boundary condition: false
name: Core 6
constant: false
initial amount: NaN
initial concentration: 1.0

metaR P4501B1r
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.14.14.1
is: SBO:0000176
reversible: false
name: cytochrome P450 1B1
notes: GENE_ASSOCIATION: (1545.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:8910454 NOTES:_4 hydroxylation of 17 beta estradiol NJ
kinetic law: MODEL1310110008#
type: Reaction
fast: false
is described by: ECO:0000269
product: MODEL1310110008#
modifier: MODEL1310110008#

metaR r0909
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
fast: false
reversible: true
reactant: MODEL1310110008#
is: SBO:0000185
product: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
name: Transport reaction
kinetic law: MODEL1310110008#

metaR HSAT1ly
product: MODEL1310110008#
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110008#
reversible: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
name: heparan-glucosaminide N-acetyltransferase, lysosomal
is described by: ECO:0000000

metaM crm hs e
name: N-acylsphingosine
boundary condition: false
is: CHEBI:52639
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
has only substance units: false
initial amount: NaN

metaR sink c101coa LPAREN c RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C101COASINK
type: Reaction

metaR DM dem2emgacpail prot hs r
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dem2emgacpail prot hs(r)
type: Reaction

metaR PUNP6
reversible: true
product: MODEL1310110008#
name: purine-nucleoside phosphorylase (Deoxyinosine)
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
kinetic law: MODEL1310110008#
is: SBO:0000176
fast: false
reactant: MODEL1310110008#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
modifier: MODEL1310110008#

metaR r2127
product: MODEL1310110008#
reactant: MODEL1310110008#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110008#
fast: false
reversible: true
modifier: MODEL1310110008#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM prostge2 c
type: Species
constant: false
is: HMDB01220
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: prostaglandin E2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: CHEBI:606564
initial amount: NaN
boundary condition: false

metaR r1154
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
type: Reaction
name: EC:1.2.7.2
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110008#
product: MODEL1310110008#
fast: false
is described by: ECO:0000000

metaR MAN6PI
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
name: mannose-6-phosphate isomerase
fast: false
type: Reaction
reactant: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000304
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.8
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:

metaR r2096
reactant: MODEL1310110008#
modifier: MODEL1310110008#
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110008#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR EX decdicrn
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decadienoyl carnitine
type: Reaction

metaR ORNDC
reversible: false
type: Reaction
kinetic law: MODEL1310110008#
product: MODEL1310110008#
name: Ornithine Decarboxylase
notes: GENE_ASSOCIATION: (4953.1) SUBSYSTEM: Urea cycle EC Number: 4.1.1.17 Confidence Level: 4 AUTHORS: PMID:2317811 NOTES:JLR- added proton to balance
is: SBO:0000176
modifier: MODEL1310110008#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/4.1.1.17

metaR RE1342C
name: RE1342
product: MODEL1310110008#
is: SBO:0000176
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
is described by: ECO:0000000
kinetic law: MODEL1310110008#

metaR r2095
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
fast: false
modifier: MODEL1310110008#
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110008#_9fd079dd_4ad9_41c0_9133_61da47662888
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10157
initial amount: NaN
type: Species
boundary condition: true
is: A4D0W4
has only substance units: false
name: AASS

metaM c16dc c
is: SBO:0000247
constant: false
is: HMDB00712
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C23H42NO6 CHARGE: -1
type: Species
name: Hexadecanedioic acid mono-L-carnitine ester

metaR PUNP7
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000176
reactant: MODEL1310110008#
name: purine-nucleoside phosphorylase (Xanthosine)
reversible: true
is described by: ECO:0000269
fast: false
product: MODEL1310110008#

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaM cgly c
is: CHEBI:4047
boundary condition: false
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
name: L-cysteinylglycine
has only substance units: false
is: HMDB00078
initial concentration: 1.0
initial amount: NaN

metaR r2126
is described by: ECO:0000000
fast: false
modifier: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000185
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

metaM co2 c
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: CO2 CHARGE: 0
is: HMDB01967
constant: false
is: SBO:0000247
boundary condition: false
name: CO2
is: CHEBI:3313
is: C00011
initial concentration: 1.0

metaM cmp c
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: HMDB00095
is: CHEBI:60377
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
name: CMP
boundary condition: false
initial concentration: 1.0
is: C00055

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_526ed4ff_7c8e_4078_9056_7dfad2eea0d9
is encoded by: hsa:23428
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
name: SLC7A8
is: Q86U05
boundary condition: true
has only substance units: false

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaR r1680
fast: false
type: Reaction
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110008#
is: SBO:0000185
reversible: false
is described by: ECO:0000000
product: MODEL1310110008#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110008#

metaM 5htrp c
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
name: 5-hydroxy-L-tryptophan
type: Species
boundary condition: false
is: HMDB00472
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17780
has only substance units: false

metaR r2094
is described by: ECO:0000000
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
product: MODEL1310110008#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_69b1cc91_4616_46a5_9593_3318d98324e6
is encoded by: hsa:2592
is: SBO:0000252
type: Species
is: B2RAT6
constant: false
name: GALT
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR C141ACBP
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradecenoyl coa from mitochondria into cytosol
type: Reaction

metaR EX digalsgalside hs LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Digalactosylceramidesulfate exchange
type: Reaction

metaR GGT6
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: true
fast: false
name: Gamma-glutamyltransferase
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_972e0c71_d82a_46eb_ad2c_e573b3066642
initial concentration: NaN
name: ACAA2
initial amount: NaN
is encoded by: hsa:10449
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is: P42765

metaM crm hs g
type: Species
name: N-acylsphingosine
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
has only substance units: false
is: CHEBI:52639
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_9bdab7ca_ca37_4e50_ab73_b5bbef9f22f8
is encoded by: hsa:30
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: ACAA1
type: Species
constant: false
is: Q96CA6
has only substance units: false

metaR HMBS
product: MODEL1310110008#
is: SBO:0000176
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
reactant: MODEL1310110008#
name: hydroxymethylbilane synthase
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.61
fast: false
notes: GENE_ASSOCIATION: (3145.1) SUBSYSTEM: Heme synthesis EC Number: 4.3.1.8 Confidence Level: 2 AUTHORS: PMID:2875434 NOTES:
is described by: ECO:0000254

metaR HS3ly
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.10.1.1
reactant: MODEL1310110008#
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
name: heparan-N-sulfatase, lysosomal
fast: false
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_71162fb7_bcfc_4b31_97f3_f682d4b7cd58
constant: false
boundary condition: true
type: Species
is: P48426
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5305
initial amount: NaN
name: PIP4K2A

metaM 2dr1p c
name: 2-Deoxy-D-ribose 1-phosphate
type: Species
boundary condition: false
constant: false
is: C00672
initial amount: NaN
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
is: HMDB01351
is: SBO:0000247
is: CHEBI:58576
has only substance units: false
initial concentration: 1.0

metaR PHEMEtm
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
product: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV changed name to"tm" to indicate mitochondrial transport NCD
reversible: true
name: Heme transport to cytosol

metaR r1681
type: Reaction
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110008#
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110008#
reversible: false
is: SBO:0000185
product: MODEL1310110008#

metaM ivcoa m
is: CHEBI:57345
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB01113
is: SBO:0000247
name: Isovaleryl-CoA
constant: false
has only substance units: false
initial amount: NaN

metaR r1576
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000185

metaR CYTK11n
reversible: true
modifier: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000269
product: MODEL1310110008#
name: cytidylate kinase (dCMP,dGTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110008#

metaR r2129
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
product: MODEL1310110008#
modifier: MODEL1310110008#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000

metaM prostge2 e
is: SBO:0000247
is: CHEBI:606564
type: Species
has only substance units: false
name: prostaglandin E2(1-)
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
initial amount: NaN
boundary condition: false
is: HMDB01220
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_e7088084_ce52_4c09_a155_c9bbd5d01cc0
type: Species
boundary condition: true
name: AGXT
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:189
is: SBO:0000252
has only substance units: false
is: P21549

http://identifiers.org/biomodels.db/MODEL1310110008#_31950c5b_188f_4ca4_8be3_454e615055dc
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:AI222095
boundary condition: true
name: _AI222095_1_m
initial concentration: NaN
is: SBO:0000252
type: Species

metaM c16dc e
name: Hexadecanedioic acid mono-L-carnitine ester
constant: false
is: SBO:0000247
is: HMDB00712
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C23H42NO6 CHARGE: -1
boundary condition: false
initial concentration: 1.0

metaM 3hdeccoa m
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
type: Species
name: 3-hydroxyhexadecenoylcoa
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB02288
initial amount: NaN

metaM octdececoa c
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: HMDB06351
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
name: octadecenoylcoa

metaR r1682
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110008#
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110008#
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_d822e75e_71c8_4247_a8ff_70076915c9cb
name: GGT1
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2678
is: P19440
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110008#_88ec63f5_eaa8_4258_82bd_5306d0697e72
is encoded by: hsa:54576
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: Q5DSZ6
initial concentration: NaN
name: UGT1A8

metaR ACACt2m
reversible: true
name: Acetoacetate mitochondrial transport via H+ symport
is: SBO:0000185
reactant: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#
is described by: ECO:0000269
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
product: MODEL1310110008#
fast: false

metaR PRO Dtde
reactant: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
fast: false
reversible: true
product: MODEL1310110008#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
is described by: ECO:0000134
name: D-proline transport, extracellular

metaR GLYCTDle
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
name: difussion of glycerol accross the brush border membrane
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110008#

metaR RE3003M
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
product: MODEL1310110008#
reactant: MODEL1310110008#
name: RE3003
is version of: http://identifiers.org/ec-code/5.3.3.8
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110008#

metaR OCDCAtr
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
name: fatty acid transport via diffusion
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110008#
is: SBO:0000185
type: Reaction
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_db1dd69c_325a_4429_84a2_082c1c9d2980
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:492
type: Species
constant: false
name: ATP2B3
initial amount: NaN
is: Q16720
boundary condition: true

metaM ksii core4 deg1 l
is: HMDB00868
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
has only substance units: false
constant: false
boundary condition: false
name: keratan sulfate II (core 4-linked), degradation product 1
is: SBO:0000247
is: CHEBI:57737

http://identifiers.org/biomodels.db/MODEL1310110008#_2f0efb4a_e9bf_491d_aaa8_3d39895aa922
initial concentration: NaN
has only substance units: false
name: ALPP
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
is: P05187
is encoded by: hsa:250
constant: false

metaR EX 4mptnl LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-methylpentanal Exchange
type: Reaction

metaM subeac x
type: Species
initial amount: NaN
notes: FORMULA: C8H12O4 CHARGE: -2
name: suberic acid
is: SBO:0000247
boundary condition: false
is: HMDB00893
has only substance units: false
constant: false
initial concentration: 1.0

metaR r1150
is described by: ECO:0000000
product: MODEL1310110008#
reversible: false
type: Reaction
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
fast: false
name: Facilitated diffusion
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000185

metaM glyb c
has only substance units: false
constant: false
is: HMDB00043
initial amount: NaN
name: glycine betaine
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17750
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719

metaR r1578
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000185
product: MODEL1310110008#

metaM ksi pre25 g
type: Species
name: keratan sulfate I biosynthesis, precursor 25
is: C00130
initial concentration: 1.0
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
is: HMDB00175
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110008#_3c10d12e_bd42_41c7_b2e6_e3e5fab35ae5
is encoded by: hsa:6342
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
name: SCP2
is: C9JC79
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_88123789_7257_4712_98d2_0d8c30c63520
is: P49189
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
name: ALDH9A1
is encoded by: hsa:223
initial concentration: NaN
constant: false

metaM xol7ah2al c
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
type: Species
is: CHEBI:27428
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB06894

http://identifiers.org/biomodels.db/MODEL1310110008#_aac83e0f_838c_46ce_98cd_d0a8375e39ab
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
name: NDUFV2
is: P19404
type: Species
initial amount: NaN
is encoded by: hsa:4729
has only substance units: false

metaR SQLSr
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
type: Reaction
fast: false
name: Squalene synthase
is version of: http://identifiers.org/ec-code/2.5.1.21
is described by: ECO:0000134
product: MODEL1310110008#
is: SBO:0000176
reactant: MODEL1310110008#
reversible: false
modifier: MODEL1310110008#

metaR r1684
product: MODEL1310110008#
type: Reaction
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110008#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
fast: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#

metaR r1861
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
name: Y+LAT2 Utilized transport
fast: false
is described by: ECO:0000000
reactant: MODEL1310110008#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#

metaR RE0452M
is: SBO:0000176
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
name: RE0452
is described by: ECO:0000000
type: Reaction
product: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
reversible: true

metaR r2099
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reversible: true
is: SBO:0000185
modifier: MODEL1310110008#
is described by: ECO:0000000
kinetic law: MODEL1310110008#
product: MODEL1310110008#

metaM 3ttetddcoa m
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: 3-hydroxy trans5,8tetradecadienoyl coa
is: HMDB02014
has only substance units: false

metaM 2octpencoa m
initial concentration: 1.0
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false
name: 2,6,9,12,15-octadecapentenoylcoa
constant: false

metaR r1579
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110008#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110008#
product: MODEL1310110008#
reversible: true
type: Reaction

metaM cmp g
type: Species
is: HMDB00095
initial concentration: 1.0
constant: false
name: CMP(2-)
is: CHEBI:60377
boundary condition: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_598f11ea_58d7_40db_a25c_a244c316137a
is encoded by: hsa:11226
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is: Q8NCL4
name: GALNT6
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_ee558f5b_083f_4737_9526_004abd986b67
is encoded by: hsa:56623
is: SBO:0000252
boundary condition: true
is: Q9NRR6
type: Species
initial concentration: NaN
has only substance units: false
name: INPP5E
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_93229432_1c8b_4965_be23_0f1fb1cd5278
is encoded by: hsa:84076
type: Species
constant: false
initial concentration: NaN
is: Q9H0I9
name: TKTL2
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM fn2m2masn g
is: CHEBI:32984
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1

metaM CE5121 m
initial concentration: 1.0
is: CHEBI:57449
has only substance units: false
type: Species
name: trans-3-decenoyl-CoA
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
boundary condition: false
constant: false
initial amount: NaN

metaM 12ppd S c
is: SBO:0000247
constant: false
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
is: CHEBI:29002
boundary condition: false
initial amount: NaN
is: HMDB06213
type: Species
has only substance units: false
name: (S)-propane-1,2-diol
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_96ecdb65_3ae9_4acd_a32d_9fff276f7ff4
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q99519
initial amount: NaN
is encoded by: hsa:4758
name: NEU1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_0509f07f_14bf_4fcc_b007_f70c719a5ef0
is: A6NFM2
name: PYCR1
boundary condition: true
initial amount: NaN
is encoded by: hsa:5831
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM glyald c
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: SBO:0000247
is: C00577
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: HMDB01051
name: D-Glyceraldehyde
initial concentration: 1.0
is: CHEBI:17378
boundary condition: false

metaR CHOLtu
kinetic law: MODEL1310110008#
fast: false
modifier: MODEL1310110008#
reactant: MODEL1310110008#
reversible: true
name: Choline uniport
type: Reaction
is described by: ECO:0000269
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
is: SBO:0000185

metaM arachdcrn r
has only substance units: false
is: CHEBI:57368
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: HMDB06523
type: Species
name: C20:4 carnitine
constant: false
boundary condition: false

metaR SQLEr
is version of: http://identifiers.org/ec-code/1.14.13.132
kinetic law: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
modifier: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
reversible: false
fast: false
name: Squalene epoxidase, endoplasmic reticular (NADP)
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD

metaR EX 3octdeccrn
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyoctadecanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_b29ed84a_9605_4210_abcc_b0fe01c9d73c
initial concentration: NaN
boundary condition: true
name: PC
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:5091
has only substance units: false
type: Species
is: P11498

metaR PTPATe
fast: false
name: PTPATe
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
product: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_f62ea3d5_b144_4582_a062_9d14d21205ab
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:26
initial amount: NaN
is: P19801
is: SBO:0000252
constant: false
has only substance units: false
name: ABP1

metaM glyald m
name: D-glyceraldehyde
boundary condition: false
constant: false
is: HMDB01051
is: CHEBI:17378
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
has only substance units: false
is: SBO:0000247

metaR r1685
type: Reaction
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110008#
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: false
is: SBO:0000185
fast: false
modifier: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_8f925eff_a6a4_4eea_93ee_4a363fcdc3fe
is: O60331
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:23396
is: SBO:0000252
constant: false
boundary condition: true
name: PIP5K1C

metaR CLPNDCOAtx
name: fatty acid intracellular transport
type: Reaction
kinetic law: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110008#
reversible: true
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_3fb07925_123d_4e64_9ecc_b1bdbc9dac97
initial concentration: NaN
name: NDUFV1
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:4723
constant: false
is: E5KNH5
boundary condition: true
initial amount: NaN

metaM 5adtststerones c
initial amount: NaN
initial concentration: 1.0
is: HMDB06278
has only substance units: false
type: Species
name: 5alpha-Dihydrotestosterone sulfate
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032

http://identifiers.org/biomodels.db/MODEL1310110008#_45842824_9aa2_4fc7_9aa4_7de454d8bba1
is: Q96QD8
type: Species
is encoded by: hsa:54407
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
name: SLC38A2

metaR r1686
fast: false
reactant: MODEL1310110008#
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
product: MODEL1310110008#
reversible: false

metaR PSSA1 hs
reactant: MODEL1310110008#
reversible: true
fast: false
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.8.29
name: Phosphatidylserine synthase homo sapiens
is described by: ECO:0000269
product: MODEL1310110008#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ

metaM tcynt e
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
has only substance units: false
name: thiocyanate
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB01453
constant: false
type: Species
is: CHEBI:18022

metaR r1573
reversible: true
kinetic law: MODEL1310110008#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110008#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110008#
fast: false

metaM 5HPET c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
boundary condition: false
is: CHEBI:57450
initial amount: NaN
type: Species
name: 5(S)-HPETE(1-)
is: SBO:0000247
is: HMDB01193
constant: false

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

metaR 3MOPte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110008#
is: SBO:0000185
product: MODEL1310110008#
fast: false
reversible: true
kinetic law: MODEL1310110008#
name: Transport of 3-methyl-2-oxopentanoate
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110008#_534664b2_6fe6_49dc_94e1_4ca9801cfddc
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:349565
name: NMNAT3
is: Q96T66
constant: false
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN

metaR OROTGLUt
reversible: true
fast: false
is described by: ECO:0000134
reactant: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: OROTGLUt
is: SBO:0000185
kinetic law: MODEL1310110008#

metaM ksi deg22 l
constant: false
name: keratan sulfate I, degradation product 22
initial amount: NaN
is: HMDB01354
initial concentration: 1.0
notes: FORMULA: C132H214N9O111S5 CHARGE: -5
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:57455
is: SBO:0000247

metaM c226coa c
constant: false
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205479
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
boundary condition: false
type: Species
is: C16169
name: cervonyl coenzyme A

metaR INSTt2r
fast: false
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
modifier: MODEL1310110008#
is described by: ECO:0000269
reactant: MODEL1310110008#
name: inositol transport in via proton symport
reversible: true
kinetic law: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
is: SBO:0000185

metaR CYSGLTH
name: Glutathione:cystine oxidoreductase
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
reactant: MODEL1310110008#
reversible: true
product: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#

metaR EX c5dc
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glutaryl carnitine
type: Reaction

metaR C10DCc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoylcarnitine
type: Reaction

metaR r1574
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_62237545_0b5c_4f7b_af0c_e21991d70d51
boundary condition: true
is: P35790
is: SBO:0000252
initial concentration: NaN
name: CHKA
constant: false
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:1119

metaR C162ACBP
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxy trans7,10-hexadecadienoylcoa from mitochondria into cytosol
type: Reaction

metaM c8dc x
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00893
boundary condition: false
name: suberyl carnitine
notes: FORMULA: C15H26NO6 CHARGE: -1
initial concentration: 1.0
has only substance units: false
constant: false

metaM asp L c
is: CHEBI:29991
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
name: L-aspartate(1-)
is: HMDB00191

metaM gmp g
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
has only substance units: false
is: HMDB01397
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
is: CHEBI:58115
initial concentration: 1.0
name: GMP(3-)
boundary condition: false

metaR H2CO3D
is described by: ECO:0000000
product: MODEL1310110008#
name: carboxylic acid dissociation
is version of: http://identifiers.org/ec-code/4.2.1.1
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
reactant: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
is: SBO:0000176
reversible: true
type: Reaction

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_39f2526a_da8e_42db_80cd_95663913a452
initial concentration: NaN
has only substance units: false
type: Species
is: D3DX95
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:1103
name: CHAT

metaR r1260
type: Reaction
product: MODEL1310110008#
is: SBO:0000176
name: EC:6.2.1.3
fast: false
is described by: ECO:0000000
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaM 5adtststerones e
is: HMDB06278
constant: false
initial concentration: 1.0
type: Species
name: 5alpha-Dihydrotestosterone sulfate
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032

metaR FAOXC181C161x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C18:1-->C16:1)x
type: Reaction

metaR B3GNT39g
modifier: MODEL1310110008#
type: Reaction
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reversible: false
reactant: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
kinetic law: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#

metaM adpac c
constant: false
has only substance units: false
is: HMDB00448
name: adipic acid
notes: FORMULA: C6H8O4 CHARGE: -2
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species

metaR r1575
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110008#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_91ea8107_8da2_4466_afa5_8e03d8d9ae8f
type: Species
boundary condition: true
constant: false
has only substance units: false
is: Q99424
name: ACOX2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8309

metaM tcynt c
name: thiocyanate
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
has only substance units: false
is: HMDB01453
type: Species
constant: false
initial amount: NaN
is: CHEBI:18022
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_22d3a944_ad06_482c_9a1b_20f4da38a4bc
is encoded by: hsa:219
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: ALDH1B1
boundary condition: true
constant: false
has only substance units: false
is: P30837
type: Species

metaM duri e
name: Deoxyuridine
initial amount: NaN
type: Species
constant: false
is: CHEBI:16450
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: C00526
initial concentration: 1.0
is: HMDB00012
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_7e4412ec_cc75_4a06_a947_8dd1016be546
is: SBO:0000252
is encoded by: hsa:1339
is: Q02221
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
name: COX6A2

http://identifiers.org/biomodels.db/MODEL1310110008#_41f5f7c7_7200_4fb7_a847_3742ef007895
is encoded by: hsa:570
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: Q14032
constant: false
name: BAAT
is: SBO:0000252

metaM core6 l
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: HMDB00143
is: CHEBI:12936
type: Species
constant: false
name: Core 6
initial amount: NaN

metaM vacc e
name: trans-vaccenate
is: CHEBI:30828
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_ba4bb026_880f_4f6a_931e_e7987e85b62d
has only substance units: false
is encoded by: hsa:151531
is: O95045
initial amount: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252
name: UPP2
initial concentration: NaN

metaM asp L e
name: L-aspartate(1-)
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00191
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
has only substance units: false
type: Species
is: CHEBI:29991
initial amount: NaN

metaM vacc c
is: CHEBI:30828
initial concentration: 1.0
name: trans-vaccenate
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
type: Species
is: C08367
constant: false

metaM 3ttetddcoa c
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: HMDB02014
boundary condition: false
initial amount: NaN
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
name: 3-hydroxy trans5,8tetradecadienoyl coa

http://identifiers.org/biomodels.db/MODEL1310110008#_1410a1cf_8758_4542_896e_6edb28674a0c
initial amount: NaN
is: Q15111
type: Species
initial concentration: NaN
name: PLCL1
constant: false
is: SBO:0000252
is encoded by: hsa:5334
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_85dad3f0_f84f_4bed_8480_a4a63360d20f
has only substance units: false
is encoded by: hsa:1629
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
name: DBT
is: P11182
boundary condition: true
is: SBO:0000252

metaR NDP8
is version of: http://identifiers.org/ec-code/2.7.4.9
is: SBO:0000176
reversible: false
fast: false
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110008#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110008#
kinetic law: MODEL1310110008#
name: nucleoside-diphosphatase (dUDP)
reactant: MODEL1310110008#

metaR CYTK5n
type: Reaction
name: cytidylate kinase (CMP),nuclear
product: MODEL1310110008#
modifier: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110008#
is described by: ECO:0000269

metaM 3thexddcoa m
is: HMDB02014
notes: FORMULA: C37H58N7O18P3S CHARGE: -4
has only substance units: false
constant: false
initial amount: NaN
name: 3-hydroxy trans7,10-hexadecadienoylcoa
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_20a2a180_cb34_4718_8e46_fe4daf3c9012
has only substance units: false
initial amount: NaN
is: P11168
constant: false
is encoded by: hsa:6514
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
name: SLC2A2

metaR S6T18g
type: Reaction
is: SBO:0000176
modifier: MODEL1310110008#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.8.2.17
reactant: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.21
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110008#
product: MODEL1310110008#

metaM udpg c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58367
is: C00029
name: UDPglucose
type: Species
is: SBO:0000247
is: HMDB00286
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
boundary condition: false
has only substance units: false

metaR PUNP1
kinetic law: MODEL1310110008#
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110008#
name: purine-nucleoside phosphorylase (Adenosine)
is: SBO:0000176
reactant: MODEL1310110008#
product: MODEL1310110008#
reversible: true

metaM c4dc x
is: HMDB02013
has only substance units: false
name: succinyl carnitine
notes: FORMULA: C11H18NO6 CHARGE: -1
is: http://identifiers.org/pubchem.compound/213144
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
is: C02862
boundary condition: false

metaR r1262
type: Reaction
name: EC:6.2.1.3
is: SBO:0000176
fast: false
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaR 5ADTSTSTERONESULT
type: Reaction
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES:NJ
is described by: ECO:0000269
fast: false
name: 5alpha-Dihydrotestosterone sulfotransferase
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.14
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_a3739984_11b0_423f_aea0_a98c9480c673
name: SLC29A1
boundary condition: true
initial concentration: NaN
is: Q99808
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:2030

metaM taur x
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
boundary condition: false
is: HMDB00251
initial amount: NaN
is: CHEBI:15891
is: SBO:0000247
name: taurine
has only substance units: false
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_e75d372a_7056_4577_9745_f59c64a72c9c
initial concentration: NaN
is: P48200
name: IREB2
constant: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:3658
is: SBO:0000252
has only substance units: false

metaR CEPTE
notes: GENE_ASSOCIATION: (10390.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
kinetic law: MODEL1310110008#
reversible: false
modifier: MODEL1310110008#
is described by: ECO:0000269
name: ethanolamine phosphotransferase
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.8.2
type: Reaction
reactant: MODEL1310110008#
is: SBO:0000176

metaM 3mb2coa m
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
type: Species
initial amount: NaN
name: 3-methylbut-2-enoyl-CoA(4-)
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB01493
is: CHEBI:57344
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_8230e05f_65ea_4a52_b069_c3f26b059b3d
has only substance units: false
is encoded by: hsa:5137
initial concentration: NaN
is: Q8NB10
initial amount: NaN
name: PDE1C
boundary condition: true
constant: false
is: SBO:0000252
type: Species

metaM duri c
is: HMDB00012
name: Deoxyuridine
type: Species
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: CHEBI:16450
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: C00526

http://identifiers.org/biomodels.db/MODEL1310110008#_e4a68986_cd5f_478f_b247_671dcb9e48c2
initial concentration: NaN
type: Species
is encoded by: hsa:3242
is: B3KQ63
is: SBO:0000252
name: HPD
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

metaR r1570
reactant: MODEL1310110008#
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110008#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR XOL7AONEtr
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110008#
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110008#

metaR PUNP2
product: MODEL1310110008#
reversible: true
type: Reaction
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110008#
name: purine-nucleoside phosphorylase (Deoxyadenosine)

metaM triodthy e
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
is: CHEBI:18258
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00265
name: 3,3',5-triiodo-L-thyronine

http://identifiers.org/biomodels.db/MODEL1310110008#_71c2d8d3_1237_4cb9_965b_2a4f2ca1e587
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5211
initial concentration: NaN
name: PFKL
is: P17858
initial amount: NaN

metaM 3oddcoa m
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
has only substance units: false
constant: false
is: HMDB03937
is: CHEBI:27868
is: SBO:0000247
initial concentration: 1.0
name: 3-Oxododecanoyl-CoA
type: Species
boundary condition: false
initial amount: NaN

metaR PUNP4
name: purine-nucleoside phosphorylase (Deoxyguanosine)
reversible: true
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
product: MODEL1310110008#
modifier: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110008#_d2998ace_3ed2_4d3e_9f1d_e8f6cf948f9e
is: SBO:0000252
is encoded by: hsa:2591
type: Species
boundary condition: true
name: GALNT3
initial concentration: NaN
constant: false
has only substance units: false
is: Q14435
initial amount: NaN

metaM crm hs c
is: CHEBI:52639
initial concentration: 1.0
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
constant: false
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: N-acylsphingosine

metaM eipencoa x
constant: false
name: 2,5,8,11,14-eicosapentaenoylcoa
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790

http://identifiers.org/biomodels.db/MODEL1310110008#_9edcae3f_058d_4dd3_9e8f_9fc64e00ac0e
is encoded by: hsa:3420
type: Species
is: O43837
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
name: IDH3B
is: SBO:0000252
initial amount: NaN

metaR r1571
type: Reaction
product: MODEL1310110008#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110008#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110008#

metaR TSULt4 3
is: SBO:0000185
fast: false
name: thiosulfate transport via sodium symport
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
reversible: true
product: MODEL1310110008#
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_5433e265_53c6_485a_a3e2_547bc05674a4
is: SBO:0000252
has only substance units: false
type: Species
is: P48651
name: PTDSS1
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:9791

metaR ANTHte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
kinetic law: MODEL1310110008#
name: Transport of anthranilate
type: Reaction
product: MODEL1310110008#
is: SBO:0000185
fast: false
reactant: MODEL1310110008#
reversible: true

metaR FUMAC
is version of: http://identifiers.org/ec-code/3.7.1.2
reversible: false
reactant: MODEL1310110008#
name: fumarylacetoacetase
fast: false
kinetic law: MODEL1310110008#
is: SBO:0000176
modifier: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110008#_0eeec52a_8f62_440a_a9e3_90d457356d21
boundary condition: true
constant: false
is encoded by: hsa:6901
name: TAZ
initial concentration: NaN
initial amount: NaN
type: Species
is: Q16635
has only substance units: false
is: SBO:0000252

metaR PYDXDH
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/1.2.3.1
kinetic law: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
reactant: MODEL1310110008#
reversible: false
name: pyridoxal dehydrogenase
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.2.3.1 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:IT

metaR PUNP3
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110008#
name: purine-nucleoside phosphorylase (Guanosine)
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
reactant: MODEL1310110008#
modifier: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reversible: true

metaR FAOXC12C10m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)m
type: Reaction

metaR r1591
product: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true

metaR EX ahdt LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 7,8-dihydroneopterin 3-triphosphate(4-)
type: Reaction

metaM hco3 m
is: C00288
type: Species
constant: false
boundary condition: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17544
name: Bicarbonate
is: HMDB00595

metaM m5mpdol U r
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:37634
has only substance units: false
notes: FORMULA: C1545H2540N20O470P20 CHARGE: -20
initial concentration: 1.0
constant: false
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaR ALOX52
product: MODEL1310110008#
reversible: false
fast: false
is described by: ECO:0000269
name: Arachidonate 5-lipoxygenase
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.13.11.34
is: SBO:0000176
reactant: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764

metaM phe L c
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00159
constant: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: CHEBI:17295
initial amount: NaN
name: L-phenylalanine

http://identifiers.org/biomodels.db/MODEL1310110008#_bff58fb9_d8c7_4bb0_8e2b_57adf12976bb
type: Species
name: _AI480132_1_c
is encoded by: hsa:AI480132
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110008#_780c00f4_42ae_4b63_8251_ea396f40d5ff
is: P43353
is encoded by: hsa:221
initial concentration: NaN
name: ALDH3B1
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_f34f25f0_e3eb_4c70_b58f_39d5ccc39aca
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:2109
boundary condition: true
name: ETFB
constant: false

metaR FACOAL240
is: SBO:0000176
name: fatty-acid--CoA ligase
modifier: MODEL1310110008#
fast: false
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaM cs b deg2 l
notes: FORMULA: C37H54NO41S3 CHARGE: -5
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB01354
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
is: CHEBI:57455
initial amount: NaN
constant: false

metaR DADNt4
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is: SBO:0000185
name: deoxyadenosine transport via diffusion
fast: false
kinetic law: MODEL1310110008#
reversible: true
is described by: ECO:0000000
product: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#

metaM 4hexdtetcoa m
initial concentration: 1.0
constant: false
type: Species
is: HMDB02288
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: 4,7,10,13-hexadecatetraenoylcoa
boundary condition: false

metaM apoC Lys c
initial amount: NaN
constant: false
notes: FORMULA: C6H13N2OX CHARGE: 0
initial concentration: 1.0
has only substance units: false
is: CHEBI:32551
boundary condition: false
name: Apocarboxylase (Lys residue)
type: Species
is: HMDB00182
is: SBO:0000247

metaR DCK2n
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.74
name: Deoxycytidine kinase, nuclear (UTP)
reactant: MODEL1310110008#
fast: false
is described by: ECO:0000269
reversible: true
product: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
kinetic law: MODEL1310110008#

metaR r0638
reactant: MODEL1310110008#
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction
is described by: ECO:0000000
product: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.8.1.2
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:

metaM ptdcacrn c
type: Species
is: CHEBI:15811
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: pendtadenoyl carnitine
initial concentration: 1.0
is: HMDB01721
constant: false
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1

metaM gpail hs c
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
initial concentration: 1.0
is: CHEBI:17049
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_b4d34c7e_593a_4083_81a4_df345a0fd780
name: PYCRL
initial concentration: NaN
is: Q53H96
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:65263
is: SBO:0000252
constant: false

metaM odecrn c
is: SBO:0000247
boundary condition: false
name: octadecenoyl carnitine
constant: false
is: CHEBI:57394
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
type: Species
is: HMDB01114
is: C00412

metaR r1590
kinetic law: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaM e4hglu m
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
is: HMDB02273
is: CHEBI:6331
constant: false
has only substance units: false
is: SBO:0000247
name: erythro-4-hydroxy-L-glutamate(1-)
type: Species
initial concentration: 1.0

metaM subeac c
name: suberic acid
has only substance units: false
boundary condition: false
notes: FORMULA: C8H12O4 CHARGE: -2
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00893

metaM gua e
is: SBO:0000247
type: Species
is: CHEBI:16235
name: guanine
initial concentration: 1.0
has only substance units: false
is: HMDB00132
constant: false
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_35714b50_72b1_4b4c_8f07_5b150e20e054
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:5538
boundary condition: true
constant: false
is: SBO:0000252
is: Q6FGQ4
type: Species
name: PPT1

http://identifiers.org/biomodels.db/MODEL1310110008#_417dcdbc_711e_4dbd_adac_192b008b54bd
initial amount: NaN
is: P24666
type: Species
constant: false
has only substance units: false
is encoded by: hsa:52
initial concentration: NaN
boundary condition: true
name: ACP1
is: SBO:0000252

metaR HAS2
is described by: ECO:0000269
name: hyaluronan synthase
reversible: false
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.1.212
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110008#
product: MODEL1310110008#

metaR FACOAL241
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110008#
is: SBO:0000176
reactant: MODEL1310110008#
product: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
is described by: ECO:0000000

metaR DHCHOLESTANATEtm
reversible: true
fast: false
reactant: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110008#
name: lipid, flip-flop intracellular transport

metaR TYRt
fast: false
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
name: L-tyrosine transport
type: Reaction
reactant: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000269
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_02e7aaf6_2cd4_40df_8658_1dbf1c2a2d7f
boundary condition: true
is: Q96G03
name: PGM2
initial concentration: NaN
type: Species
is encoded by: hsa:55276
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252

metaM hista c
is: SBO:0000247
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:58432
is: HMDB00870
type: Species
constant: false
name: histamium

metaR FUMTSULtm
reactant: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110008#
is described by: ECO:0000269
product: MODEL1310110008#
name: Fumarate:thiosulfate antiport, mitochondrial
is: SBO:0000185
reversible: true
fast: false

metaM thcholoylcoa x
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-8-9-30-36-31(12-15-48(29,30)6)47(5)14-11-28(56)19-27(47)20-33(36)58)7-10-32(57)26(2)45(63)79-18-17-50-35(59)13-16-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-34-39(74-76(64,65)66)38(60)44(73-34)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,26?,27+,28-,29-,30+,31+,32?,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
name: 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA
is: HMDB12456
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:27403
boundary condition: false
type: Species

metaM phe L e
is: SBO:0000247
boundary condition: false
is: HMDB00159
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:17295
initial amount: NaN
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
name: L-phenylalanine

http://identifiers.org/biomodels.db/MODEL1310110008#_81c77fb7_18c4_4ba9_a98b_d34ad4ed159f
initial amount: NaN
has only substance units: false
is encoded by: hsa:1892
boundary condition: true
constant: false
is: P30084
initial concentration: NaN
name: ECHS1
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110008#_ddd1eb44_6be2_4372_bd4e_59ec7649e514
is encoded by: hsa:26289
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
name: AK5
constant: false

metaM m4mpdol U r
initial amount: NaN
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: CHEBI:37633

metaR DHCR243r
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
name: 24-dehydrocholesterol reductase [Precursor]
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.3.1.72
reactant: MODEL1310110008#
is: SBO:0000176
product: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
fast: false
reversible: false
is described by: ECO:0000134

metaR ADRNCRNt
reactant: MODEL1310110008#
is: SBO:0000185
product: MODEL1310110008#
is described by: ECO:0000000
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (788.1) or (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
name: transport into the mitochondria (carnitine)
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110008#_54d5521a_f5fe_4bcc_9e57_8d55218bfc71
initial concentration: NaN
is: B2RB13
name: ACSL6
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:23305
initial amount: NaN
type: Species

metaM triodthy c
initial concentration: 1.0
type: Species
is: CHEBI:18258
constant: false
is: HMDB00265
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
boundary condition: false
has only substance units: false
initial amount: NaN
name: 3,3',5-triiodo-L-thyronine
is: SBO:0000247

metaR FACOAL1831
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
fast: false
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110008#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110008#

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR RE0830N
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.96
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110008#
modifier: MODEL1310110008#
fast: false
name: RE0830

http://identifiers.org/biomodels.db/MODEL1310110008#_1a6b0167_6e32_44b7_ac1c_300622f503e9
name: _PRO1933_1_m
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:PRO1933
constant: false

metaR BMTer L
type: Reaction
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
reactant: MODEL1310110008#
reversible: false
is: SBO:0000176
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
product: MODEL1310110008#
name: B mannosyltransferase, endoplasmic reticulum
fast: false
is described by: ECO:0000000

metaM gua c
type: Species
is: CHEBI:16235
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: C00242
is: HMDB00132
constant: false
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
boundary condition: false
name: Guanine

http://identifiers.org/biomodels.db/MODEL1310110008#_015213af_24b2_4004_a303_d36d105e8dca
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is encoded by: hsa:80347
initial amount: NaN
is: Q13057
name: COASY
has only substance units: false

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaM hexe3coa x
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
type: Species
name: 3-hexenoylcoa
is: SBO:0000247
is: HMDB06522
constant: false

metaR FMNAT
name: FMN adenylyltransferase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.2
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
reversible: false
product: MODEL1310110008#
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110008#
fast: false
modifier: MODEL1310110008#

metaR MG2er
reversible: false
reactant: MODEL1310110008#
is described by: ECO:0000000
kinetic law: MODEL1310110008#
product: MODEL1310110008#
fast: false
is: SBO:0000176
type: Reaction
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD

metaM HC00591 m
is: SBO:0000247
constant: false
name: 2-oxoglutaramate
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
initial amount: NaN
type: Species
is: CHEBI:16769
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR FACOAL1832
is described by: ECO:0000269
kinetic law: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110008#
reversible: true
name: fatty-acid--CoA ligase
fast: false
reactant: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE3114C
modifier: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_df5e9385_6a4e_44eb_a15d_63fb3f5c919d
type: Species
boundary condition: true
constant: false
name: COQ6
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:51004
has only substance units: false
initial concentration: NaN
is: B7Z3K8

metaM hista e
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
initial concentration: 1.0
is: HMDB00870
is: CHEBI:58432
has only substance units: false
constant: false
boundary condition: false
type: Species
name: histamium

metaR 4HBZFm
kinetic law: MODEL1310110008#
is described by: ECO:0000000
name: 4-hydroxybenzoate formation
reactant: MODEL1310110008#
reversible: false
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.

metaR S6TASE13ly
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110008#
is: SBO:0000176
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110008#
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110008#
fast: false

metaR r0787
is: SBO:0000176
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
fast: false
type: Reaction
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000000
kinetic law: MODEL1310110008#
reversible: false
reactant: MODEL1310110008#
modifier: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_1380303e_14bc_40d3_8c92_8d2d0f402a5c
name: SRD5A2
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: P31213
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:6716

metaM tymsf e
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
name: Tyramine O-sulfate
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB06409

http://identifiers.org/biomodels.db/MODEL1310110008#_d1f15f6d_b360_47bf_9ea9_f72973ac0697
initial concentration: NaN
name: AK2
is: SBO:0000252
is: P54819
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:204
has only substance units: false
type: Species

metaR PYDXtr
type: Reaction
product: MODEL1310110008#
name: Pyridoxal transport
is described by: ECO:0000000
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT
fast: false
reactant: MODEL1310110008#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110008#_e4a8e1f0_c9d8_4529_b1cd_0e7c8aa251cf
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:374291
is: SBO:0000252
name: NDUFS7
initial concentration: NaN
constant: false
is: O75251

metaM Rtotal3 c
is: HMDB01448
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: R total 3 position
is: CHEBI:16189
boundary condition: false
notes: FORMULA: CO2FULLR3 CHARGE: -1

metaM 3thexddcoa c
has only substance units: false
name: 3-hydroxy trans7,10-hexadecadienoylcoa
constant: false
is: SBO:0000247
notes: FORMULA: C37H58N7O18P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
is: HMDB02014
type: Species
boundary condition: false

metaR GLCt2 2
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:
reversible: true
name: D-glucose transport in via proton symport
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000269
modifier: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
is: SBO:0000185
type: Reaction

metaR FACOAL181i
product: MODEL1310110008#
is described by: ECO:0000269
reactant: MODEL1310110008#
modifier: MODEL1310110008#
name: C181 fatty acid activation
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110008#
reversible: false
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
is: SBO:0000176
type: Reaction

metaM acald r
is: CHEBI:15343
has only substance units: false
is: HMDB00990
is: SBO:0000247
type: Species
name: acetaldehyde
initial concentration: 1.0
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
constant: false
initial amount: NaN
boundary condition: false

metaM pydxn c
is: HMDB00239
type: Species
has only substance units: false
name: Pyridoxine
initial amount: NaN
is: C00314
constant: false
initial concentration: 1.0
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
is: CHEBI:16709
is: SBO:0000247
boundary condition: false

metaM 7dhf e
initial concentration: 1.0
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
is: SBO:0000247
initial amount: NaN
is: HMDB06559
name: heptaglutamyl folate (DHF)
boundary condition: false
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_6062cb20_ce9c_4fc5_bc69_3adc8bbe2fe0
is encoded by: hsa:39
is: SBO:0000252
type: Species
initial amount: NaN
name: ACAT2
boundary condition: true
constant: false
has only substance units: false
is: Q9BWD1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_37053c04_aac3_4ffd_bd53_5f47800720ad
is: Q9H903
type: Species
name: MTHFD2L
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:441024
initial concentration: NaN
boundary condition: true

metaR EX coa LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for coa
type: Reaction

metaR SULFOX
product: MODEL1310110008#
reversible: false
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.8.3.1
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14729666 NOTES:MM/TDV; r0140
reactant: MODEL1310110008#
is described by: ECO:0000134
name: sulfite oxidase
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110008#

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaR EX glygn4 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_ee8fe9f4_07ae_413f_86b6_b8835f3d382e
initial amount: NaN
constant: false
boundary condition: true
is: P23378
type: Species
is: SBO:0000252
is encoded by: hsa:2731
name: GLDC
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_ebaf9e1a_b860_4521_9a89_ce8408375690
constant: false
boundary condition: true
is encoded by: hsa:1103
is: SBO:0000252
initial concentration: NaN
is: D3DX95
name: CHAT
type: Species
has only substance units: false
initial amount: NaN

metaM strdnccrn m
type: Species
is: HMDB06463
notes: FORMULA: C25H41NO4 CHARGE: 0 INCHI: InChI=1/C25H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h6-7,9-10,13-14,17-18,23H,5,8,11-12,15-16,19-22H2,1-4H3/b7-6-,10-9-,14-13-,18-17-
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
name: stearidonyl carnitine

metaR r0789
reversible: true
reactant: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
type: Reaction
kinetic law: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110008#_402061e9_7b78_4e99_9574_53345b9899e1
initial concentration: NaN
is: SBO:0000252
name: PECR
is: Q9BY49
is encoded by: hsa:55825
initial amount: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false

metaM CE2433 m
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:57795

metaM tymsf c
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
has only substance units: false
name: Tyramine O-sulfate
is: HMDB06409
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
type: Species

metaR AMPDA
is described by: ECO:0000269
product: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.5.4.6
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110008#
reversible: false
reactant: MODEL1310110008#
name: Adenosine monophosphate deaminase
fast: false

metaM CE4872 c
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:15748
is: SBO:0000247
is: HMDB00127
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
initial amount: NaN
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
boundary condition: false
constant: false

metaR FAOXC185m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_01bd5c79_8e99_46ef_81ac_f4a56df29a5a
is encoded by: hsa:221
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P43353
name: ALDH3B1

metaR AHEXASEly
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110008#
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110008#

metaR r0788
is: SBO:0000176
reversible: true
reactant: MODEL1310110008#
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110008#
is described by: ECO:0000000
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
product: MODEL1310110008#

metaM sebcoa c
boundary condition: false
name: sebacoylcoa
constant: false
is: HMDB00651
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_d0c2db85_75a7_4012_98fd_975c6c95d88a
boundary condition: true
name: PLCB1
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:23236
is: SBO:0000252
constant: false
initial amount: NaN

metaR NACHEX26ly
product: MODEL1310110008#
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

metaR AG13T12g
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.1.149

http://identifiers.org/biomodels.db/MODEL1310110008#_b9542e4a_32e7_47ef_8d8a_04e5f5bed5d8
type: Species
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:3157
is: SBO:0000252
name: HMGCS1
initial concentration: NaN

metaR ACACT1r
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110008#
name: acetyl-CoA C-acetyltransferase
kinetic law: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.3.1.9
modifier: MODEL1310110008#
fast: false

metaM strdnccrn c
is: HMDB06463
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C25H41NO4 CHARGE: 0 INCHI: InChI=1/C25H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h6-7,9-10,13-14,17-18,23H,5,8,11-12,15-16,19-22H2,1-4H3/b7-6-,10-9-,14-13-,18-17-
has only substance units: false
type: Species
name: stearidonyl carnitine

metaM dolp L c
is: SBO:0000247
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
type: Species
is: CHEBI:57683
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: dolichyl phosphate(2-)
constant: false

metaR NDPK9n
is described by: ECO:0000269
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
modifier: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
reversible: true
product: MODEL1310110008#
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR NDPK8
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110008#
name: Nucleoside-diphosphate kinase (ATP:dADP)
product: MODEL1310110008#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110008#
fast: false
is: SBO:0000176

metaM udpg r
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Species
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: HMDB00286
is: CHEBI:58367

metaR FAOXC142C142OHm
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C14:2OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_595c4e7c_fa1d_421a_948a_409bcc365f71
constant: false
has only substance units: false
name: _AI824319_1_r
is encoded by: hsa:AI824319
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN

metaR NACHEX24ly
reversible: false
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110008#

metaM thmmp c
is: CHEBI:37575
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: Thiamin monophosphate
initial amount: NaN
is: HMDB02666
type: Species
is: C01081
constant: false
boundary condition: false
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081

metaR RE0830C
reversible: true
reactant: MODEL1310110008#
is described by: ECO:0000000
kinetic law: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is: SBO:0000176
fast: false
name: RE0830
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_003ec93f_924f_4a67_bee9_472d1ff8c45b
initial concentration: NaN
has only substance units: false
name: NOS1
boundary condition: true
is: B4DG68
is encoded by: hsa:4842
initial amount: NaN
type: Species
is: SBO:0000252
constant: false

metaR r1877
name: Y+LAT2 Utilized transport
reversible: false
type: Reaction
product: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110008#
is: SBO:0000185
modifier: MODEL1310110008#

metaR r0630
modifier: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.3.1
is described by: ECO:0000000
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.2

metaR ARACHCRNt
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000185
modifier: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110008#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR FOLR2
is: SBO:0000176
fast: false
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.5.1.3
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
modifier: MODEL1310110008#
is described by: ECO:0000254
product: MODEL1310110008#
type: Reaction
name: folate reductase
reversible: false

metaR NDPK7
name: nucleoside-diphosphate kinase (ATP:dCDP)
kinetic law: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000269

metaM lgnc c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
is: SBO:0000247
is: HMDB02003
is: CHEBI:31014
initial amount: NaN
boundary condition: false
name: lignocerate
constant: false
type: Species

metaM taur c
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00251
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: Taurine
notes: FORMULA: C2H7NO3S CHARGE: 0
is: CHEBI:3544
is: C00245

http://identifiers.org/biomodels.db/MODEL1310110008#_6510799d_86e6_4188_929d_bc1cfd00729c
constant: false
is encoded by: hsa:4709
initial amount: NaN
name: NDUFB3
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q6IB80
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_7583c900_a7ec_4fca_a005_e0bc610ce19f
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:440
name: ASNS
is: B4DXZ1
boundary condition: true

metaR FAOXC164C163x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_811310cc_9cc0_4af6_955d_9837f439c9d9
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
name: GCDH
is encoded by: hsa:2639
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q92947

http://identifiers.org/biomodels.db/MODEL1310110008#_45457e3b_bbcb_4e6c_83a3_d4b038f2f3b2
boundary condition: true
initial concentration: NaN
is: Q9Y2C5
is: SBO:0000252
is encoded by: hsa:10050
name: SLC17A4
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaM hdcea r
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB03229
has only substance units: false
name: palmitoleate
is: CHEBI:32372
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_abb808ed_6f7a_4811_9665_b9932507d255
initial amount: NaN
is: Q96L53
is encoded by: hsa:6487
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: ST3GAL3
has only substance units: false

metaR PGLer
modifier: MODEL1310110008#
name: 6-phosphogluconolactonase, endoplasmic reticulum
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.47
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
reversible: false
is described by: ECO:0000269
is: SBO:0000176

metaM ptdcacrn m
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
is: HMDB01721
is: CHEBI:15811
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
name: pendtadenoyl carnitine
initial amount: NaN
has only substance units: false

metaR ACACt2
name: acetoacetate transport via proton symport
fast: false
is: SBO:0000185
reactant: MODEL1310110008#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110008#
reversible: true
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
kinetic law: MODEL1310110008#

metaR DM gpi sig er
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaR C5DCe
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of glutaryl carnitine into the extra cellular fluid
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_211f56ee_eff2_4ab4_881b_409df5db3e53
boundary condition: true
has only substance units: false
type: Species
is: Q8N0X4
initial amount: NaN
name: CLYBL
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:171425

metaR MECOAS1m
reversible: true
fast: false
product: MODEL1310110008#
is: SBO:0000176
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
reactant: MODEL1310110008#
is described by: ECO:0000304
name: mesaconate--CoA ligase (GDP-forming)
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_26e39001_3817_4566_9eb6_6d0623aba200
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
name: AMDHD2
type: Species
is encoded by: hsa:51005
is: Q9Y303

metaM taur e
is: CHEBI:3544
type: Species
initial amount: NaN
name: Taurine
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C2H7NO3S CHARGE: 0
is: HMDB00251
is: C00245
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_cf1edd2b_8ff4_45db_9617_e63dfc013266
name: _AI601100_1_m
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:AI601100
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR CDIPTr
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
modifier: MODEL1310110008#
name: phosphatidylinositol synthase (Homo sapiens)
reversible: true
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.11
product: MODEL1310110008#
reactant: MODEL1310110008#
fast: false

metaM 5dpmev c
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1
constant: false
initial concentration: 1.0
is: HMDB01090
initial amount: NaN
boundary condition: false
name: (R)-5-Diphosphomevalonate

http://identifiers.org/biomodels.db/MODEL1310110008#_954411ca_0211_4775_9665_5e8b2b038298
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is: P48735
boundary condition: true
is encoded by: hsa:3418
initial concentration: NaN
type: Species
name: IDH2

metaM lgnc e
name: lignocerate
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB02003
is: CHEBI:31014
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
initial amount: NaN
constant: false
type: Species
boundary condition: false

metaM ksi pre8 g
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 8
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaR NDPK9
fast: false
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
reversible: true
name: nucleoside-diphosphate kinase (ATP:IDP)
reactant: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110008#_4e16bc40_e0ea_45bd_a4ad_0688a9db8406
initial concentration: NaN
is: Q9Y217
boundary condition: true
has only substance units: false
is encoded by: hsa:9107
name: MTMR6
constant: false
type: Species
is: SBO:0000252
initial amount: NaN

metaR G12MT2 U
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
reversible: false
kinetic law: MODEL1310110008#
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
is: SBO:0000176
product: MODEL1310110008#
fast: false

metaR ILETA
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
product: MODEL1310110008#
is described by: ECO:0000269
name: isoleucine transaminase
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.6.1.42
modifier: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
type: Reaction

metaR OCCOAtx
product: MODEL1310110008#
fast: false
is described by: ECO:0000000
name: fatty acid intracellular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
reversible: true

metaR RETFA
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
name: retinol acyltransferase
kinetic law: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
reversible: false
product: MODEL1310110008#
is: SBO:0000176
fast: false

metaR GALASE12ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
reversible: false
name: beta-galactosidase, lysosomal
is: SBO:0000176

metaR NDPK4
product: MODEL1310110008#
type: Reaction
fast: false
reactant: MODEL1310110008#
is described by: ECO:0000269
kinetic law: MODEL1310110008#
name: nucleoside-diphosphate kinase (ATP:dTDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110008#
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110008#_5c76509f_ee05_4010_b75c_de34dbe977fb
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5152
name: PDE9A
type: Species
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false

metaR FAOXC13C11m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C13-->C11)m
type: Reaction

metaR r0634
modifier: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.1
reversible: true
is described by: ECO:0000000
type: Reaction
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000176

metaM noncoa m
initial concentration: 1.0
is: C01942
name: nonanoylcoa
initial amount: NaN
boundary condition: false
notes: FORMULA: C30H48N7O17P3S CHARGE: -4
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB13028

metaR PPDOy
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
type: Reaction
modifier: MODEL1310110008#
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110008#
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.21
reversible: false
fast: false
is: SBO:0000176

metaR r2122
reactant: MODEL1310110008#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110008#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110008#
modifier: MODEL1310110008#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_d7d0bb5a_5b9a_492f_9c5f_7bb9792f947c
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: Q6LEN5
boundary condition: true
name: CHAT
initial amount: NaN
is encoded by: hsa:1103

metaM 3hbcoa m
name: (S)-3-hydroxybutanoyl-CoA(4-)
is: HMDB01166
has only substance units: false
is: SBO:0000247
is: CHEBI:57316
constant: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR RE1530C
product: MODEL1310110008#
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
name: RE1530

http://identifiers.org/biomodels.db/MODEL1310110008#_ab573eb5_1f81_4dd3_96e6_d75149a33001
is: Q5TEK5
is: SBO:0000252
name: PDE4B
is encoded by: hsa:5142
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false

metaM HC00591 c
is: CHEBI:16769
boundary condition: false
constant: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: 2-oxoglutaramate
type: Species

metaR ARGtm
is described by: ECO:0000269
reactant: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000185
kinetic law: MODEL1310110008#
name: arginine mitochondrial transport via ornithine carrier
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110008#

metaR NDPK3
modifier: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: true
fast: false
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:CDP)
product: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6

http://identifiers.org/biomodels.db/MODEL1310110008#_34ab45e1_cb8d_4c4a_b94c_74a1b608651c
constant: false
boundary condition: true
is encoded by: hsa:9245
initial concentration: NaN
initial amount: NaN
type: Species
name: GCNT3
has only substance units: false
is: SBO:0000252
is: O95395

metaM acgal1p c
initial concentration: 1.0
is: CHEBI:55404
has only substance units: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
name: N-Acetyl-D-galactosamine 1-phosphate
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB06480
initial amount: NaN
type: Species

metaM 4hexdtetcoa x
is: HMDB02288
name: 4,7,10,13-hexadecatetraenoylcoa
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN

metaM tdcrn c
type: Species
constant: false
is: HMDB05066
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: myristoyl carnitine
notes: FORMULA: C21H41NO4 CHARGE: 0
initial concentration: 1.0
has only substance units: false

metaR r0633
product: MODEL1310110008#
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
modifier: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.3
kinetic law: MODEL1310110008#

metaR r2123
product: MODEL1310110008#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110008#
is described by: ECO:0000000
modifier: MODEL1310110008#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110008#

metaR NAHCO3 HCLt
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110008#
name: bicarbonate transport (HCl/NaHCO3 exchange)
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
reactant: MODEL1310110008#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_fa4c0c3e_34a1_46f1_af8a_eb53aa6c997b
has only substance units: false
is: SBO:0000252
is: Q8TCD5
initial concentration: NaN
constant: false
name: NT5C
is encoded by: hsa:30833
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_330c4ac9_9833_4149_b3f4_c111ddf93458
is encoded by: hsa:3423
is: P22304
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
name: IDS
has only substance units: false
boundary condition: true

metaM ivcoa c
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB01113
name: Isovaleryl-CoA
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_140968dc_b6a1_47d3_baf5_ba86052c97c0
is encoded by: hsa:6817
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
name: SULT1A1
boundary condition: true
has only substance units: false

metaR NDPK6
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: true
reactant: MODEL1310110008#
is described by: ECO:0000269
is: SBO:0000176
name: Nucleoside-diphosphate kinase (ATP:dUDP)
fast: false

metaR MAL Ltx
is: SBO:0000185
is described by: ECO:0000134
product: MODEL1310110008#
reversible: true
name: Transport reaction for malate
reactant: MODEL1310110008#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_a76b9bf4_4033_49c8_b0db_cc9b6f2347d9
is: SBO:0000252
is: Q09327
initial concentration: NaN
type: Species
name: MGAT3
boundary condition: true
is encoded by: hsa:4248
has only substance units: false
constant: false
initial amount: NaN

metaR PI34P5K
reactant: MODEL1310110008#
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.68
reversible: false
modifier: MODEL1310110008#
fast: false
is: SBO:0000176
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
type: Reaction
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD

metaR r1879
reversible: false
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110008#
fast: false
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110008#
modifier: MODEL1310110008#

metaM cholcoads x
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB06889
is: CHEBI:27505
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA

metaR r0355
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
kinetic law: MODEL1310110008#
is: SBO:0000176
product: MODEL1310110008#
fast: false
modifier: MODEL1310110008#
reactant: MODEL1310110008#
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.3
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:

metaR DOLPMT U
product: MODEL1310110008#
modifier: MODEL1310110008#
reactant: MODEL1310110008#
name: Dolichyl-phosphate D-mannosyltransferase (uterus)
type: Reaction
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.83
fast: false
kinetic law: MODEL1310110008#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110008#_5a967ad3_25c8_49b0_859f_9af48a888ef3
name: PDE9A
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5152
initial concentration: NaN
type: Species

metaR r2120
type: Reaction
is described by: ECO:0000000
fast: false
modifier: MODEL1310110008#
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110008#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110008#_6432256a_e84a_4710_9ef0_3bedfe597f2e
name: HSD17B4
is: E9PB82
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:3295
is: SBO:0000252
initial amount: NaN

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_3096bfe7_1883_47b0_aa8a_248969499eed
type: Species
is encoded by: hsa:5152
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: PDE9A
is: SBO:0000252
constant: false

metaR AG13T9g
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
modifier: MODEL1310110008#
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_1e070217_2712_49c2_9d9a_57666458e2cd
is: Q7Z3X3
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:2799
boundary condition: true
name: GNS
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_6021226c_a1b2_49f3_b54c_96e1925af723
is encoded by: hsa:R06874
name: _R06874_1_r
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false

metaM ksi pre32 g
boundary condition: false
constant: false
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
has only substance units: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 32
initial amount: NaN
type: Species
is: CHEBI:28067
initial concentration: 1.0

metaR NDPK5
type: Reaction
modifier: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Nucleoside-diphosphate kinase (ATP:dGDP)
kinetic law: MODEL1310110008#
is described by: ECO:0000269
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM pglyc hs c
is: SBO:0000247
is: HMDB02704
name: pglyc_hs[c]
initial concentration: 1.0
constant: false
notes: FORMULA: CHARGE: 0
is: CHEBI:21338
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false

metaM sphgn c
is: CHEBI:57817
name: sphinganine(1+)
is: SBO:0000247
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
initial amount: NaN
constant: false
is: HMDB00269
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR NCNt
is described by: ECO:0000269
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
product: MODEL1310110008#
fast: false
modifier: MODEL1310110008#
name: Na+/Ca2+-NH4+ exchange
type: Reaction
is: SBO:0000185
reactant: MODEL1310110008#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110008#_55b5fbd0_922f_4aa7_8dac_2e0e1f5a0a43
is: Q86YT5
initial concentration: NaN
name: SLC13A5
is encoded by: hsa:284111
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaM odecrn m
has only substance units: false
is: C00412
initial amount: NaN
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:57394
is: HMDB01114
name: octadecenoyl carnitine
type: Species
is: SBO:0000247

metaM tdcrn e
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB05066
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: myristoyl carnitine
notes: FORMULA: C21H41NO4 CHARGE: 0
type: Species

metaR q10h2tc
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
product: MODEL1310110008#
fast: false
name: transport of ubiquinol into cytosol
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
is described by: ECO:0000134
reversible: true

metaR FAOXTC162TC142m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C16:2-->C14:2)m
type: Reaction

metaR r2121
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110008#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110008#
reversible: true
reactant: MODEL1310110008#
fast: false
modifier: MODEL1310110008#
type: Reaction
is: SBO:0000185

metaR r0354
product: MODEL1310110008#
is: SBO:0000176
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
reversible: false
modifier: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110008#

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaR PPDOx
reactant: MODEL1310110008#
product: MODEL1310110008#
modifier: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD
type: Reaction
reversible: false
name: Propane-1,2-diol:NAD+ 1-oxidoreductase
fast: false
kinetic law: MODEL1310110008#

metaR MCLOR
reactant: MODEL1310110008#
is: SBO:0000176
modifier: MODEL1310110008#
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.27
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110008#
name: 3-Mercaptolactate:NAD+ oxidoreductase
fast: false
type: Reaction

metaR r2115
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
modifier: MODEL1310110008#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR CYTK10n
product: MODEL1310110008#
kinetic law: MODEL1310110008#
name: cytidylate kinase (CMP,dGTP),nuclear
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
modifier: MODEL1310110008#
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_f2dbaef5_ec1f_4e14_91d8_b7c124feb9f1
type: Species
is encoded by: hsa:1375
constant: false
initial amount: NaN
name: CPT1B
is: Q53FV7
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR SR5ARr
kinetic law: MODEL1310110008#
type: Reaction
reversible: false
reactant: MODEL1310110008#
fast: false
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
is version of: http://identifiers.org/ec-code/1.3.99.5
is described by: ECO:0000134
modifier: MODEL1310110008#
is: SBO:0000176
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate

http://identifiers.org/biomodels.db/MODEL1310110008#_29226be5_3b62_40a8_8e3e_235fe75eb9f8
is encoded by: hsa:26275
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q6NVY1
is: SBO:0000252
name: HIBCH
boundary condition: true
constant: false
type: Species

metaM c12dccoa x
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: dodecanedioylcoa
is: HMDB03712
boundary condition: false
constant: false
notes: FORMULA: C33H51N7O19P3S CHARGE: -5

metaM 4ppcys m
has only substance units: false
initial amount: NaN
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: SBO:0000247
boundary condition: false
is: CHEBI:59458
type: Species
initial concentration: 1.0
is: HMDB01117
constant: false
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)

http://identifiers.org/biomodels.db/MODEL1310110008#_60ef5ca7_08c7_4361_a614_31b837a40ace
name: LSS
boundary condition: true
is: E9PEI9
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4047
initial amount: NaN

metaR HMGCOASi
name: Hydroxymethylglutaryl CoA synthase (ir)
modifier: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (3157.1) or (3157.2) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:1358203 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission Made irreversible to match KEGG data for S. aureus
reversible: false
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.3.3.10
fast: false
is: SBO:0000176
reactant: MODEL1310110008#
is described by: ECO:0000269

metaR OCTDECE1CRNe
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-octadecenoyl carnitine into extra cellular space
type: Reaction

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaM dc2coa x
name: trans-Dec-2-enoyl-CoA
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB01168
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4

metaM h2o g
is: CHEBI:15377
initial amount: NaN
is: HMDB02111
name: water
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
constant: false

metaR r2114
fast: false
kinetic law: MODEL1310110008#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110008#

metaM octd11ecoa c
name: 11-octadecenoylcoa
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/5280771
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
type: Species

metaR r1143
kinetic law: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10823827 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.18.6.3
product: MODEL1310110008#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110008#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110008#

metaR RE3218C
name: RE3218
reactant: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.6.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
product: MODEL1310110008#
fast: false
reversible: true
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110008#

metaR H6ET3er
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
product: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.8.1
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110008#
is: SBO:0000176
fast: false
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_3767cb01_f35b_435c_a831_693c51bae9e7
has only substance units: false
is encoded by: hsa:11343
name: MGLL
constant: false
is: B2ZGL7
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_3457700b_46f5_4c18_9fe9_97e4e0104f7e
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is: Q9NRA0
is encoded by: hsa:56848
constant: false
initial concentration: NaN
initial amount: NaN
name: SPHK2

metaM sbcoa c
is: HMDB00791
initial amount: NaN
name: suberylcoa
boundary condition: false
constant: false
type: Species
is: C02838
initial concentration: 1.0
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_6ff03d65_b8ab_4dd4_9336_7bb595d426c6
boundary condition: true
has only substance units: false
is encoded by: hsa:84701
is: SBO:0000252
is: Q96KJ9
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
name: COX4I2

metaM k e
constant: false
has only substance units: false
is: CHEBI:29103
is: HMDB00586
boundary condition: false
is: C00238
is: SBO:0000247
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
initial concentration: 1.0
type: Species
name: potassium
initial amount: NaN

metaM acald e
name: acetaldehyde
initial concentration: 1.0
type: Species
is: HMDB00990
is: CHEBI:15343
initial amount: NaN
has only substance units: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: SBO:0000247
constant: false
boundary condition: false

metaM adrncoa x
type: Species
has only substance units: false
is: C16170
constant: false
is: SBO:0000247
name: adrenyl coenzyme A
initial amount: NaN
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205480
initial concentration: 1.0

metaR DM anth
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR r2113
product: MODEL1310110008#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reversible: true
reactant: MODEL1310110008#
fast: false
is described by: ECO:0000000

metaM dodecanac c
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: Dodecanedioic acid
has only substance units: false
initial concentration: 1.0
is: HMDB00623
notes: FORMULA: C12H20O4 CHARGE: -2
constant: false
type: Species

metaM hs deg22 l
notes: FORMULA: C37H56NO35S CHARGE: -3
initial amount: NaN
is: CHEBI:21338
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB02704
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_8513c817_6dfd_4d3e_9f2f_0a1c2be58fad
constant: false
name: CYP51A1
is: SBO:0000252
is encoded by: hsa:1595
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q16850
initial concentration: NaN
type: Species

metaR RE0453N
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110008#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000000
name: RE0453
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
product: MODEL1310110008#
type: Reaction

metaR KCC2t
modifier: MODEL1310110008#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
is: SBO:0000185
product: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
name: K+-Cl- cotransporter (NH4+)
reversible: true
kinetic law: MODEL1310110008#

metaM zymst r
constant: false
is: SBO:0000247
name: zymosterol
initial amount: NaN
is: HMDB06271
has only substance units: false
type: Species
is: CHEBI:18252
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
boundary condition: false
initial concentration: 1.0

metaR T4HCINNMFM
type: Reaction
is: SBO:0000176
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
name: 4-hydroxycinnamate formation
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
is described by: ECO:0000000
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110008#_78eb0a38_116d_427b_9fbd_a2e915eab86d
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is: B2RDZ2
is encoded by: hsa:55312
initial amount: NaN
name: RFK
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_bf4a62c0_a693_41c2_b6ca_598c3d1f002d
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: O43924
constant: false
name: PDE6D
boundary condition: true
is encoded by: hsa:5147

metaM HC01415 m
has only substance units: false
is: CHEBI:27537
is: SBO:0000247
initial amount: NaN
name: (2E)-Octenoyl-CoA
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276

metaR NDPK1
name: nucleoside-diphosphate kinase (ATP:GDP)
type: Reaction
product: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110008#
reversible: true

metaR NACHEX15ly
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110008#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
modifier: MODEL1310110008#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110008#_95d32773_a4ea_48e9_97c1_c1a96b7e1bf1
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
constant: false
is: P23921
name: RRM1
initial concentration: NaN
is encoded by: hsa:6240
initial amount: NaN

metaM adpac x
has only substance units: false
is: SBO:0000247
name: adipic acid
constant: false
notes: FORMULA: C6H8O4 CHARGE: -2
boundary condition: false
initial concentration: 1.0
is: HMDB00448
type: Species
initial amount: NaN

metaM sebcoa x
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
boundary condition: false
constant: false
name: sebacoylcoa
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966

http://identifiers.org/biomodels.db/MODEL1310110008#_59da1c04_5431_402c_8c2d_c2ca9add3461
has only substance units: false
constant: false
is encoded by: hsa:25769
is: Q9UI40
initial amount: NaN
type: Species
boundary condition: true
name: SLC24A2
initial concentration: NaN
is: SBO:0000252

metaR r1690
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110008#
type: Reaction
is: SBO:0000185
product: MODEL1310110008#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#

metaR r2112
kinetic law: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110008#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000000

metaR CMPACNAtn
name: CMP-Sia nuclear export
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110008#
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000185

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR UDPACGALtl
product: MODEL1310110008#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110008#
name: udpacgal intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
reactant: MODEL1310110008#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110008#_16b1e918_0fbe_4d35_9eef_c1deca73e152
name: GGT1
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:2678

metaM k c
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:29103
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
initial concentration: 1.0
is: HMDB00586
name: potassium
is: C00238
type: Species
is: SBO:0000247

metaR NDPK2
name: nucleoside-diphosphate kinase (ATP:UDP)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
product: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000269
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR FCLTm
reversible: false
fast: false
product: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2235.1) or (2235.2) SUBSYSTEM: Heme synthesis EC Number: 4.99.1.1 Confidence Level: 2 AUTHORS: PMID:7983009 NOTES:NCD; r0096
kinetic law: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/4.99.1.1
reactant: MODEL1310110008#
name: Ferrochelatase, mitochondrial

metaR PCHOLPm hs
is version of: http://identifiers.org/ec-code/3.1.4.4
reactant: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110008#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
reversible: false
kinetic law: MODEL1310110008#
name: choline phosphatase

metaM ksii core2 deg4 l
notes: FORMULA: C58H95N5O43SX CHARGE: -1
name: keratan sulfate II (core 2-linked), degradation product 4
is: CHEBI:57455
is: HMDB01354
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_04621d2e_a2cd_48a2_86ed_b19f683c45ab
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:5286
is: SBO:0000252
type: Species
name: PIK3C2A
constant: false
initial amount: NaN
is: O00443

metaM ksi deg14 l
type: Species
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I, degradation product 14
has only substance units: false
is: HMDB00143
boundary condition: false
is: CHEBI:12936
constant: false
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_75372c43_8313_484a_8f2a_96e61536a087
boundary condition: true
name: UMPS
is encoded by: hsa:7372
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is: A8K5J1

metaR ACCOAgt
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
reversible: true
kinetic law: MODEL1310110008#
fast: false
product: MODEL1310110008#
name: acetyl-coa transport
reactant: MODEL1310110008#

metaR r2119
reversible: true
type: Reaction
product: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110008#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110008#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110008#_6bc81b24_26de_4601_86d3_e262d499275b
name: SLC4A1
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:6521
type: Species
boundary condition: true
is: SBO:0000252
is: P02730

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_7cd996fb_7005_4b42_8496_a0948e552250
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is: Q9H936
name: SLC25A22
is encoded by: hsa:79751
type: Species
boundary condition: true

metaR LNELDCCRNt
kinetic law: MODEL1310110008#
is: SBO:0000185
reactant: MODEL1310110008#
type: Reaction
reversible: false
name: transport into the mitochondria (carnitine)
product: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110008#_a5979dd9_a1c5_45a3_a01b_724b7290f474
initial concentration: NaN
type: Species
name: PDHX
boundary condition: true
has only substance units: false
is: O00330
constant: false
is encoded by: hsa:8050
is: SBO:0000252
initial amount: NaN

metaM asn L e
boundary condition: false
is: CHEBI:17196
name: L-asparagine
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00168
is: SBO:0000247
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
type: Species

metaR UGLT
is: SBO:0000176
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
fast: false
modifier: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.7.12
reversible: true
type: Reaction
name: UDPglucose--hexose-1-phosphate uridylyltransferase
kinetic law: MODEL1310110008#

metaR DOCO13ECOAtxc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 13-docosenoylcoa into peroxisomes
type: Reaction

metaR TSTSTERONESte
product: MODEL1310110008#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
name: sulfonated testosterone transport
fast: false
reversible: true
is described by: ECO:0000000

metaM ksii core2 deg1 l
initial amount: NaN
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 1
type: Species
has only substance units: false
constant: false
is: CHEBI:57737
initial concentration: 1.0
is: HMDB00868
is: SBO:0000247
notes: FORMULA: C70H113N5O59S3X CHARGE: -3

http://identifiers.org/biomodels.db/MODEL1310110008#_35b41791_883e_4a6b_a8a9_0d0d94326668
type: Species
is: P48764
boundary condition: true
name: SLC9A3
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:6550
initial amount: NaN
has only substance units: false

metaR r2118
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
modifier: MODEL1310110008#
is: SBO:0000185
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_6d457d91_d0c1_4e31_9860_0ed56b1b092d
initial concentration: NaN
boundary condition: true
type: Species
is: O15121
is encoded by: hsa:8560
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
name: DEGS1

metaM h2o c
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:3303
notes: FORMULA: H2O CHARGE: 0
is: C00001
type: Species
initial amount: NaN
is: HMDB02111
name: H2O
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_3c036792_5615_4b3f_b4bd_d3d6b46413cf
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: UPP1
is encoded by: hsa:7378
has only substance units: false

metaM xolest2 hs e
boundary condition: false
constant: false
is: CHEBI:17002
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
name: cholesterol ester
has only substance units: false
is: SBO:0000247

metaR KYNATESYN
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000176
fast: false
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
reversible: false
reactant: MODEL1310110008#
type: Reaction

metaR DURAD
name: dihydrouracil dehydrogenase (NADP)
product: MODEL1310110008#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.2
type: Reaction
is: SBO:0000176
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
is described by: ECO:0000269
fast: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_682103b7_bee6_41c3_a922_36d3afc5503f
constant: false
name: SLC23A2
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:9962
initial amount: NaN

metaM m4mpdol U c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
type: Species
is: CHEBI:37633
has only substance units: false
is: SBO:0000247
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaR THYMDtm
type: Reaction
reactant: MODEL1310110008#
fast: false
name: thymd transport
reversible: true
is: SBO:0000185
modifier: MODEL1310110008#
is described by: ECO:0000269
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:TDV
kinetic law: MODEL1310110008#

metaM din c
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: SBO:0000247
is: C05512
has only substance units: false
boundary condition: false
constant: false
name: Deoxyinosine
is: CHEBI:28997
is: HMDB00071

metaR S2TASE1ly
modifier: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.13
product: MODEL1310110008#
name: iduronate-2-sulfatase, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
reactant: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
reversible: false

metaR FAOXTC101TC102m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:1-->C10:2)m
type: Reaction

metaM mlthf c
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:15636
is: C00143
is: SBO:0000247
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
initial amount: NaN
constant: false
boundary condition: false
name: 5,10-Methylenetetrahydrofolate
is: HMDB01533

metaM btcoa m
initial concentration: 1.0
name: Butanoyl-CoA
is: SBO:0000247
is: C00136
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
is: HMDB01088
boundary condition: false
has only substance units: false
is: CHEBI:57371

http://identifiers.org/biomodels.db/MODEL1310110008#_e6ed107c_6e79_4ef1_9168_6d701e8f32e5
constant: false
is encoded by: hsa:22978
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P49902
name: NT5C2

metaR r1588
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#
reactant: MODEL1310110008#
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR r2117
kinetic law: MODEL1310110008#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110008#
fast: false
product: MODEL1310110008#
modifier: MODEL1310110008#
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110008#_bf7ef4d0_4f6c_499c_93b4_fe53ced48026
is encoded by: hsa:6487
has only substance units: false
type: Species
name: ST3GAL3
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_3de083c5_82a9_44e4_862e_729403b035db
is: Q15067
has only substance units: false
initial concentration: NaN
name: ACOX1
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:51
boundary condition: true
is: SBO:0000252

metaM asn L c
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
initial concentration: 1.0
is: CHEBI:17196
name: L-asparagine
constant: false
boundary condition: false
type: Species
is: HMDB00168
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM tsul m
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: HMDB00257
type: Species
name: thiosulfate(2-)
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16094
boundary condition: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_7487401a_0b2f_4918_ba2a_b282068ed798
initial amount: NaN
initial concentration: NaN
type: Species
is: P50226
is: SBO:0000252
is encoded by: hsa:6799
constant: false
has only substance units: false
name: SULT1A2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_34e22b15_7872_41a0_8780_729ad6dd5f91
is: SBO:0000252
constant: false
type: Species
name: VNN3
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:55350

metaM hco3 c
is: C00288
is: SBO:0000247
is: CHEBI:17544
constant: false
boundary condition: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
initial concentration: 1.0
is: HMDB00595
initial amount: NaN
type: Species
name: Bicarbonate
has only substance units: false

metaR r1589
product: MODEL1310110008#
reversible: true
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_c1140b8b_6eaf_4346_a7c5_98c8c2590c1f
is encoded by: hsa:3633
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: INPP5B
is: SBO:0000252
is: P32019
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_65d44c38_feeb_4ba1_a3b1_fc30ad6a5e0b
initial amount: NaN
name: _AI440329_1_r
boundary condition: true
constant: false
is encoded by: hsa:AI440329
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR r2116
product: MODEL1310110008#
reactant: MODEL1310110008#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

metaM pyr m
type: Species
has only substance units: false
is: C00022
initial concentration: 1.0
name: pyruvate
is: HMDB00243
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3324
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:15361

metaR C40CPT1
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

metaM h2o e
name: H2O
initial concentration: 1.0
is: CHEBI:15377
is: HMDB02111
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
boundary condition: false
is: C00001
type: Species

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaM dcholcoa c
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: CHEBI:28701
is: HMDB06292
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: SBO:0000247
name: chenodeoxycholoyl coenzyme a

metaR ACACT1x
name: acetyl-CoA C-acetyltransferase, mitochondrial
type: Reaction
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110008#
is described by: ECO:0000134
modifier: MODEL1310110008#
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
is version of: http://identifiers.org/ec-code/2.3.1.9

metaM din e
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:28997
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
name: Deoxyinosine
type: Species
is: SBO:0000247
is: C05512
is: HMDB00071
constant: false
initial amount: NaN

metaM acald c
initial concentration: 1.0
name: acetaldehyde
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
has only substance units: false
boundary condition: false
is: CHEBI:15343
is: SBO:0000247
is: HMDB00990
type: Species
initial amount: NaN
constant: false

metaR RE1804M
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
kinetic law: MODEL1310110008#
reversible: true
is described by: ECO:0000000
product: MODEL1310110008#
name: RE1804
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reactant: MODEL1310110008#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_a156f089_8559_4d63_94c4_986b4dccf1ec
constant: false
has part: F8W7V3
is: SBO:0000297
boundary condition: true
initial concentration: NaN
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
initial amount: NaN
is encoded by: hsa:517
is encoded by: hsa:9551
type: Species

metaR TMDK1m
name: thymidine kinase (ATP:thymidine)
modifier: MODEL1310110008#
reactant: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.21
notes: GENE_ASSOCIATION: (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:9342341 NOTES:TV
is: SBO:0000176
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110008#

metaM clpndcoa x
initial amount: NaN
is: SBO:0000247
is: HMDB06267
has only substance units: false
name: clupanodonyl CoA
is: http://identifiers.org/pubchem.compound/47205476
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: C16166

metaM 3hibutcoa m
name: (S)-3-Hydroxyisobutyryl-CoA
is: CHEBI:28259
type: Species
is: SBO:0000247
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB01052
boundary condition: false
initial amount: NaN

metaM air c
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:58592
is: HMDB01235
initial amount: NaN
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
is: C03373
boundary condition: false

metaR HIVCRNe
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-isovaleryl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_6b36829c_4376_40aa_8d8e_9fc2a8daa451
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q548A7
name: SLC26A6
type: Species
is encoded by: hsa:65010
constant: false
initial amount: NaN

metaR GMPtg
reactant: MODEL1310110008#
name: GMP transport (Golgi)
is: SBO:0000185
product: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
type: Reaction
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110008#_d0495f21_fae2_4e3d_b90b_3d55f9f467c0
is encoded by: hsa:23539
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: SLC16A8
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is: O95907

metaR r1586
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110008#
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110008#

metaM cholcoa x
is: CHEBI:57373
is: HMDB01374
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: choloyl-CoA(4-)

metaR SO4tl
reactant: MODEL1310110008#
fast: false
name: Sulfate transport (lysosome)
is: SBO:0000185
is described by: ECO:0000269
reversible: true
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
kinetic law: MODEL1310110008#
type: Reaction

metaM leuktrB4 e
is: CHEBI:57461
type: Species
name: leukotriene B4(1-)
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB01085
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165

metaR r0915
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_8033ab23_0ee6_44dd_90d4_381ffd9810ec
constant: false
type: Species
is: P21953
is encoded by: hsa:594
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: BCKDHB
has only substance units: false

metaM dlnlcgcoa c
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:27979
has only substance units: false
name: dihomo-gamma-linolenyl coenzyme A

metaR r0783
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110008#
fast: false

metaR C120CPT1
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanoylcarnitine
type: Reaction

metaM hco3 e
is: HMDB00595
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: CHEBI:17544
has only substance units: false
is: C00288
boundary condition: false
initial concentration: 1.0
name: Bicarbonate
initial amount: NaN

metaR RE0453C
reactant: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
is: SBO:0000176
name: RE0453
kinetic law: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is described by: ECO:0000000
reversible: true

metaR r1587
reversible: true
product: MODEL1310110008#
is: SBO:0000185
kinetic law: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_860518c9_b3a6_4538_977e_e6c20236c189
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: PANK2
is: Q6P1K9
type: Species
is encoded by: hsa:80025
constant: false
is: SBO:0000252
has only substance units: false

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_d5b7d089_3a85_4b65_aafb_5e7f5778a707
is encoded by: hsa:AA614647
boundary condition: true
name: _AA614647_1_c
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species

metaR NAt3 1
is described by: ECO:0000269
kinetic law: MODEL1310110008#
fast: false
name: sodium proton antiporter (H:NA is 1:1)
is: SBO:0000185
modifier: MODEL1310110008#
reversible: true
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
reactant: MODEL1310110008#
type: Reaction

metaR EX CE5868 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acetyl-seryl-aspartate exchange
type: Reaction

metaR FAOXC184x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_1ad4bf32_8d14_4ccf_a046_460f7dad3751
is: SBO:0000252
initial amount: NaN
is: P30520
constant: false
initial concentration: NaN
is encoded by: hsa:159
boundary condition: true
has only substance units: false
type: Species
name: ADSS

metaM hdcea c
initial amount: NaN
has only substance units: false
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
constant: false
type: Species
boundary condition: false
is: CHEBI:32372
is: HMDB03229
name: Hexadecenoate (n-C16:1)
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_14f606b1_c98c_48c0_9a7d_f93b54787072
is: SBO:0000252
is encoded by: hsa:2203
name: FBP1
initial amount: NaN
has only substance units: false
type: Species
is: Q2TU34
boundary condition: true
constant: false
initial concentration: NaN

metaR 4NPHte
reversible: true
name: xenobiotic transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
kinetic law: MODEL1310110008#
type: Reaction
is: SBO:0000185
product: MODEL1310110008#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110008#

metaM apoC Lys m
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00182
name: Apocarboxylase (Lys residue)
constant: false
initial amount: NaN
is: CHEBI:32551
is: SBO:0000247
notes: FORMULA: C6H13N2OX CHARGE: 0

metaR r1584
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110008#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110008#_adc290a8_0b87_4d7b_a046_c354309534b7
is encoded by: hsa:57786
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is: Q9NYW8
has only substance units: false
name: RBAK
constant: false

metaR MAL Lte
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
name: Transport of L-malate
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_b70e6d2b_6966_4cdd_b2dc_6070894133ce
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:8854
boundary condition: true
name: ALDH1A2
is: SBO:0000252
is: O94788
type: Species
initial amount: NaN

metaR FAOXC12C12OHm
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->OHC12)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_49b916f7_3f9a_49b4_99e1_04b626f66d69
is encoded by: hsa:2235
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: FECH
is: P22830
has only substance units: false
constant: false
initial amount: NaN

metaR CMPACNAtg
reversible: true
reactant: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
name: CMP-Sia Golgi transport via CMP antiport
is: SBO:0000185
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
kinetic law: MODEL1310110008#
is described by: ECO:0000269
fast: false

metaR r0784
is version of: http://identifiers.org/ec-code/1.3.1.38
fast: false
product: MODEL1310110008#
is: SBO:0000176
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110008#

metaM octd11ecoa m
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
name: 11-octadecenoylcoa
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: HMDB06294
constant: false

metaM 3dpdhb me m
is: CHEBI:50776
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
type: Species
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C58H87O4 CHARGE: -1 INCHI: InChI=1S/C58H88O4/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58(60)61)43-56(62-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43,59H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3,(H,60,61)/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+

metaM Rtotal3 e
has only substance units: false
name: R total 3 position
constant: false
notes: FORMULA: CO2FULLR3 CHARGE: -1
boundary condition: false
is: C00255
is: CHEBI:3554
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00244

http://identifiers.org/biomodels.db/MODEL1310110008#_8fbdbd3d_a632_4b29_b025_df3fbc14ee7d
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: _T83654_1_c
is encoded by: hsa:T83654
type: Species

metaR ST8SIA11
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is: SBO:0000176
name: Beta-galactoside alpha-2,3-sialyltransferase
type: Reaction
reactant: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.8
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
reversible: false

metaR r0913
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110008#
is: SBO:0000185

metaM btcoa x
has only substance units: false
name: Butanoyl-CoA
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: C00136
notes: FORMULA: C25H38N7O17P3S CHARGE: -4
is: HMDB01088
type: Species
constant: false

metaR ST8SIA12
is version of: http://identifiers.org/ec-code/2.4.99.8
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
reversible: false
is: SBO:0000176
name: Beta-galactoside alpha-2,3-sialyltransferase
fast: false
reactant: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000000

metaR r1585
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110008#
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR DUTPDP
fast: false
reactant: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: Confidence Level: 3 AUTHORS: NOTES:
kinetic law: MODEL1310110008#
is: SBO:0000176
reversible: false
product: MODEL1310110008#
is described by: ECO:0000134
name: dUTP diphosphatase

metaR GLXO1
reversible: false
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.2.4
fast: false
type: Reaction
name: glyoxylate oxidase
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.27
is: SBO:0000176
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (3939.1) or (55293.1) or (3945.1 and 3939.1) or (197257.1) or (92483.1) or (3945.1) or (160287.1) or (3948.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.3.5 Confidence Level: 4 AUTHORS: PMID:12768081,PMID:9038835,PMID:9604807,PMID:9783918 NOTES:NCD

metaM hdcea e
name: Hexadecenoate (n-C16:1)
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: CHEBI:32372
is: HMDB03229
initial amount: NaN

metaM pyr e
is: HMDB00243
is: CHEBI:15361
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
name: pyruvate
type: Species
has only substance units: false

metaM citr L e
name: citr_L[e]
type: Species
initial amount: NaN
is: CHEBI:16349
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00904
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277

metaR 4MOPte
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 4-methyl-2-oxopentanoate
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000134
reactant: MODEL1310110008#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110008#_8c21cf52_7b2a_45dd_b5db_1531b3c9a9c9
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is: Q16678
is encoded by: hsa:1545
initial concentration: NaN
initial amount: NaN
name: CYP1B1
constant: false

metaR DHPR2
is described by: ECO:0000304
is: SBO:0000176
fast: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3735413 NOTES:IT
product: MODEL1310110008#
type: Reaction
name: 6,7-dihydropteridine reduction
reversible: false
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_1062b5e5_11db_4b10_baf6_0306f95b6825
constant: false
name: PYCR2
type: Species
is encoded by: hsa:29920
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q96C36

metaM tsul c
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
constant: false
initial amount: NaN
name: thiosulfate(2-)
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: CHEBI:16094
initial concentration: 1.0
is: HMDB00257

http://identifiers.org/biomodels.db/MODEL1310110008#_447d3a40_a06f_4e53_8972_398e3e824101
name: ESCO2
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:157570
is: SBO:0000252
boundary condition: true
is: Q56NI9
initial amount: NaN

metaR CYTK6n
fast: false
reversible: true
kinetic law: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110008#
is described by: ECO:0000269
type: Reaction
name: cytidylate kinase (CMP,CTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110008#
modifier: MODEL1310110008#

metaR GLYC3Ptmc
reversible: true
kinetic law: MODEL1310110008#
product: MODEL1310110008#
name: glycerol-3-phopshate transport, cytoplasm
is described by: ECO:0000134
reactant: MODEL1310110008#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: added during gap filling. No evidence found for such a reaction. NOTES:added during gap filling. No evidence found for such a reaction.

metaR PROSTGI2t
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: true
fast: false
name: Prostaglandin I2 transport
product: MODEL1310110008#

metaR BTNDm
kinetic law: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#
is: SBO:0000176
fast: false
reversible: false
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
is version of: http://identifiers.org/ec-code/3.5.1.12
product: MODEL1310110008#
name: biotinidase (biotin), mitochondrial
reactant: MODEL1310110008#
is described by: ECO:0000269

metaR NOt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
product: MODEL1310110008#
is described by: ECO:0000000
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
is: SBO:0000185
reversible: true
name: NO transport (diffusion)

metaM ksi pre24 g
constant: false
boundary condition: false
is: C00130
type: Species
is: HMDB00175
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
is: CHEBI:58053
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 24

http://identifiers.org/biomodels.db/MODEL1310110008#_c3e07d6d_2926_4d24_88b9_3188e10a9a83
is encoded by: hsa:10400
constant: false
name: PEMT
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_cf230668_9cac_4fb8_bf92_95463e61ee3e
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:AU149534
is: SBO:0000252
name: _AU149534_1_e

http://identifiers.org/biomodels.db/MODEL1310110008#_a8c250fa_c2c9_4d67_8d1e_12d000d619c4
initial amount: NaN
type: Species
constant: false
is: E9PAK4
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: SLC5A9
is encoded by: hsa:200010

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

metaR HDCACBP
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR r1583
fast: false
reversible: true
reactant: MODEL1310110008#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX doco13ac
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_1ecf8f98_26dc_4f3b_bc86_728d3f5aab7d
is: Q9NP56
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:27115
constant: false
boundary condition: true
name: PDE7B

metaM dhcrm hs c
is: CHEBI:31488
has only substance units: false
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: dihydroceramide
initial concentration: 1.0
constant: false
type: Species

metaM dolp L r
type: Species
name: dolichyl phosphate(2-)
boundary condition: false
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57683
initial amount: NaN
constant: false
has only substance units: false

metaM pectindchac e
initial amount: NaN
type: Species
name: pectin-deoxycholic acid complex
constant: false
notes: FORMULA: C2559H3549O2539 CHARGE: -1
is: HMDB03402
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM citr L c
is: HMDB00904
type: Species
is: CHEBI:16349
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: L-citrulline
boundary condition: false
constant: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_15214634_2979_4a49_ae0e_0653fd591546
is encoded by: hsa:686
type: Species
has only substance units: false
constant: false
name: BTD
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P43251

metaM pyr c
is: HMDB00243
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3324
boundary condition: false
name: pyruvate
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1
constant: false
is: CHEBI:15361
type: Species
is: C00022
initial concentration: 1.0

metaM hs deg14 l
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
name: heparan sulfate, degradation product 14
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:16126
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_5a5dcab6_c02d_4179_9b61_7ee6aa9d3113
name: _H45672_1_m
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:H45672
initial amount: NaN
has only substance units: false

metaM dc2coa m
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
type: Species
constant: false
is: CHEBI:61406
name: trans-Dec-2-enoyl-CoA
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_55849d4e_5508_4347_bc01_05927d58a383
is: P00813
initial concentration: NaN
boundary condition: true
name: ADA
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:100

metaR r1580
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110008#
is: SBO:0000185
product: MODEL1310110008#
reversible: true
type: Reaction
kinetic law: MODEL1310110008#
is described by: ECO:0000000

metaM dec47dicoa x
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: 4,7-decadienoylcoa
constant: false
initial concentration: 1.0
type: Species

metaR r0780
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110008#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
reactant: MODEL1310110008#
fast: false
type: Reaction
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110008#_579d8336_2f11_421b_84e4_530334e6fcfa
name: NME4
is: SBO:0000252
is: O00746
constant: false
is encoded by: hsa:4833
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN

metaR METtec
name: L-methionine transport via diffusion (extracellular to cytosol)
modifier: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reactant: MODEL1310110008#
reversible: true
type: Reaction
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110008#
is: SBO:0000185

metaM tsul e
initial amount: NaN
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
name: thiosulfate(2-)
is: SBO:0000247
is: CHEBI:16094
type: Species
constant: false
is: HMDB00257
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR PGDI
is version of: http://identifiers.org/ec-code/5.3.99.2
is version of: http://identifiers.org/ec-code/2.5.1.18
reactant: MODEL1310110008#
name: Prostaglandin-H2 D-isomerase [Precursor]
fast: false
modifier: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
kinetic law: MODEL1310110008#
is described by: ECO:0000269
reversible: true
type: Reaction

metaM pcrn c
name: propionyl-carnitine
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/107738
is: HMDB00824
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3

metaM dem2emgacpail prot hs r
initial amount: NaN
constant: false
notes: FORMULA: C37H70N3O34P3FULLRCO2FULLR2CO2X CHARGE: 0
name: deacylated-(phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
has only substance units: false
is: CHEBI:53486
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB02925
type: Species

metaR r0917
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110008#

metaM asn L m
boundary condition: false
name: L-asparagine
initial amount: NaN
is: HMDB00168
has only substance units: false
is: SBO:0000247
is: CHEBI:17196
constant: false
initial concentration: 1.0
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
type: Species

metaM mlthf m
initial amount: NaN
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: HMDB01533
boundary condition: false
name: 5,10-Methylenetetrahydrofolate
constant: false
is: SBO:0000247
is: CHEBI:15636
type: Species
is: C00143
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_ec076267_c178_4568_b3e3_ba6f8d1be85b
is encoded by: hsa:9334
is: O43286
has only substance units: false
type: Species
name: B4GALT5
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false

metaR AKR1D
is described by: ECO:0000269
kinetic law: MODEL1310110008#
reversible: false
modifier: MODEL1310110008#
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.3.1.3
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
is: SBO:0000176
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
type: Reaction
fast: false

metaR DCK1n
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
is: SBO:0000176
type: Reaction
reversible: true
modifier: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.74
fast: false
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
name: Deoxycytidine kinase, nuclear (ATP)

metaM 2dp6mobq me m
is: CHEBI:50772
initial concentration: 1.0
name: 2-decaprenyl-6-methoxy-3-methyl-1,4-benzoquinone
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C58H88O3 CHARGE: 0 INCHI: InChI=1S/C58H88O3/c1-44(2)23-14-24-45(3)25-15-26-46(4)27-16-28-47(5)29-17-30-48(6)31-18-32-49(7)33-19-34-50(8)35-20-36-51(9)37-21-38-52(10)39-22-40-53(11)41-42-55-54(12)56(59)43-57(61-13)58(55)60/h23,25,27,29,31,33,35,37,39,41,43H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+,53-41+
initial amount: NaN
type: Species
boundary condition: false

metaM C05957 r
initial concentration: 1.0
is: CHEBI:27485
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
type: Species
name: Prostaglandin J2
is: SBO:0000247
is: HMDB02710

metaR r0781
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
modifier: MODEL1310110008#
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: true
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR r1581
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110008#
type: Reaction
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaM c81coa c
boundary condition: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
is: HMDB03949
name: octenoylcoa
has only substance units: false
initial amount: NaN
type: Species
is: C05276
constant: false

metaM CE2250 e
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C43H72N7O18P3S CHARGE: -4 INCHI: InChI=1S/C43H76N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-31(51)26-34(53)72-25-24-45-33(52)22-23-46-41(56)38(55)43(2,3)28-65-71(62,63)68-70(60,61)64-27-32-37(67-69(57,58)59)36(54)42(66-32)50-30-49-35-39(44)47-29-48-40(35)50/h29-30,32,36-38,42,54-55H,4-28H2,1-3H3,(H,45,52)(H,46,56)(H,60,61)(H,62,63)(H2,44,47,48)(H2,57,58,59)/t32-,36-,37-,38+,42-/m1/s1 EHMN_ABBREVIATION: CE2250
initial concentration: 1.0
name: 3-oxodocosanoyl-CoA
has only substance units: false
is: SBO:0000247
is: CHEBI:52328
boundary condition: false

metaR r1381
reactant: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
is: SBO:0000176

metaM udpacgal c
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
is: HMDB00304
name: UDP-N-acetyl-D-galactosamine(2-)
initial concentration: 1.0
is: CHEBI:57847
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial amount: NaN
constant: false

metaR r0791
is: SBO:0000176
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110008#
reversible: true
modifier: MODEL1310110008#
fast: false

metaR HBZOPT10m
kinetic law: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (27235.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:15153069,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.5.1.- IT
reversible: false
product: MODEL1310110008#
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.5.1.39
modifier: MODEL1310110008#
is: SBO:0000176
name: Hydroxybenzoate Decaprenyltransferase
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110008#_3061ed92_44b2_4cd5_bd0a_3c7201a47c6b
constant: false
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:5728
is: F6KD01
is: SBO:0000252
name: PTEN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_b3cb11a1_91a1_49a1_a901_4492eb436aa5
name: PRDX1
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:5052
initial amount: NaN
is: SBO:0000252
constant: false
is: Q06830

metaM ctp c
is: SBO:0000247
is: C00063
name: CTP
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:37563
has only substance units: false
constant: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial concentration: 1.0
is: HMDB00082

metaR r2378
type: Reaction
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110008#
product: MODEL1310110008#

metaR ALAtN1
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269
is: SBO:0000185
name: Alanine transport (Na, H coupled)
fast: false
product: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: true
modifier: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_e1a7779e_f265_494b_8be5_236b6db3ddd4
initial amount: NaN
is: SBO:0000252
is: P47895
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
name: ALDH1A3
is encoded by: hsa:220
type: Species

metaR r1380
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000176
reactant: MODEL1310110008#
fast: false

metaR PRPPS
modifier: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
fast: false
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: true
name: phosphoribosylpyrophosphate synthetase
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.6.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110008#_49352bec_e572_41e9_a86c_6f229013c653
name: SLC6A2
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:6530
is: SBO:0000252
is: Q96KH8

metaR EX succ LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Succinate exchange
type: Reaction

metaR GALASE5ly
modifier: MODEL1310110008#
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
fast: false
type: Reaction

metaR EX gthox LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxidized glutathione exchange
type: Reaction

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaR LALDO
is: SBO:0000176
reactant: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.1
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
kinetic law: MODEL1310110008#

metaM h e
constant: false
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
is: CHEBI:24636
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: "
is: C00080
has only substance units: false
boundary condition: false
initial amount: NaN
name: proton
type: Species

metaR OMHPALTD
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

metaM 3hexdtetcoa m
boundary condition: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
name: 3,7,10,13-hexadecatetraenoylcoa
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB02288
constant: false

metaR C121CPT1
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecenoylcarnitine
type: Reaction

metaM btamp c
type: Species
has only substance units: false
name: Biotinyl-5'-AMP
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:3110
is: SBO:0000247
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
boundary condition: false
is: HMDB04220

http://identifiers.org/biomodels.db/MODEL1310110008#_b2e7e76b_517d_4d07_bdae_1a17507197ea
type: Species
initial concentration: NaN
is encoded by: hsa:8867
boundary condition: true
is: O43426
is: SBO:0000252
has only substance units: false
name: SYNJ1
initial amount: NaN
constant: false

metaR r2379
is: SBO:0000185
reactant: MODEL1310110008#
product: MODEL1310110008#
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110008#

metaR FAOXC226C227m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

metaR EX CE2250 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-oxodocosanoyl-CoA exchange
type: Reaction

metaR r0680
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
type: Reaction
product: MODEL1310110008#
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.137
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110008#

metaR FAOXC122C101m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

metaM tmndnccoa m
is: SBO:0000247
type: Species
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB06514
name: timnodonyl coenzyme A
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1

metaM ctp e
initial concentration: 1.0
initial amount: NaN
name: CTP(4-)
type: Species
constant: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
boundary condition: false
is: CHEBI:37563
is: HMDB00082
is: SBO:0000247
has only substance units: false

metaR FACOAL1813
fast: false
product: MODEL1310110008#
type: Reaction
reversible: true
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110008#
name: fatty-acid--CoA ligase
is: SBO:0000176
is described by: ECO:0000269

metaM saccrp L m
is: HMDB00279
boundary condition: false
notes: FORMULA: C11H19N2O6 CHARGE: -1 INCHI: InChI=1S/C11H20N2O6/c12-7(10(16)17)3-1-2-6-13-8(11(18)19)4-5-9(14)15/h7-8,13H,1-6,12H2,(H,14,15)(H,16,17)(H,18,19)/p-1/t7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00363
initial amount: NaN
has only substance units: false
name: L-saccharopinate(1-)
is: CHEBI:57951
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_50182e8a_a12d_4162_bb44_3c524f05b5f1
initial concentration: NaN
name: SLC14A2
has only substance units: false
initial amount: NaN
is encoded by: hsa:8170
constant: false
is: SBO:0000252
type: Species
is: Q15849
boundary condition: true

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaM pail4p hs c
boundary condition: false
is: CHEBI:58178
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
initial concentration: 1.0

metaR r0792
product: MODEL1310110008#
modifier: MODEL1310110008#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
reactant: MODEL1310110008#
reversible: true
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_308913e1_63d2_4d75_8504_3b13d7f8bbd9
type: Species
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:8818
is encoded by: hsa:5277
has only substance units: false
boundary condition: true
initial amount: NaN
has part: P37287
constant: false
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ

metaM vacccrn m
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
is: HMDB06351
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
name: Vaccenyl carnitine
boundary condition: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_b9583a74_596b_4fcc_96de_8b8dec0b4ab4
initial concentration: NaN
is encoded by: hsa:AI971036
constant: false
is: SBO:0000252
name: _AI971036_1_x
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN

metaM eitetcoa m
name: 5,8,11,14-eicosatetraenoylcoa
constant: false
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790

metaM h c
boundary condition: false
name: proton
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: "
type: Species
is: C00080
is: http://identifiers.org/pubchem.compound/3380
constant: false
has only substance units: false
is: CHEBI:24636
is: SBO:0000247
initial amount: NaN

metaR PAPtg
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110008#
name: adenosine 3',5'-bisphosphate Golgi transport
is: SBO:0000185
fast: false
kinetic law: MODEL1310110008#
reversible: false
reactant: MODEL1310110008#

metaR FAOXC225m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_80a5f95d_16e3_4156_ad87_9151710fb991
is: Q5TDP6
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:51557
type: Species
name: LGSN
boundary condition: true
is: SBO:0000252

metaM cortsn r
initial concentration: 1.0
type: Species
notes: FORMULA: C21H28O5 CHARGE: 0 INCHI: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00762
name: cortisone
initial amount: NaN
boundary condition: false
is: HMDB02802
constant: false
is: CHEBI:16962
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_b9662119_6c42_4916_89df_ac565cffd883
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI631997
initial amount: NaN
name: _AI631997_1_m
initial concentration: NaN
has only substance units: false
constant: false

metaR r2079
is: SBO:0000185
reversible: true
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
modifier: MODEL1310110008#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110008#
is described by: ECO:0000000

metaR NDPK4n
reversible: true
is: SBO:0000176
is described by: ECO:0000304
product: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
modifier: MODEL1310110008#
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110008#

metaR PEAMNO
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.21
product: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
fast: false
name: Phenethylamine oxidase
reversible: false
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
is described by: ECO:0000304
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.4.3.4
is version of: http://identifiers.org/ec-code/1.4.3.22

http://identifiers.org/biomodels.db/MODEL1310110008#_cb40ad78_f7ad_4259_9018_790a00f20b66
name: CA12
constant: false
type: Species
is: O43570
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:771

metaM ethamp c
boundary condition: false
type: Species
has only substance units: false
name: ethamp[c]
initial concentration: 1.0
constant: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: CHEBI:58190
initial amount: NaN
is: HMDB00224
is: SBO:0000247

metaM ksi pre22 g
name: keratan sulfate I biosynthesis, precursor 22
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
is: C00130
initial concentration: 1.0
is: HMDB00175
has only substance units: false
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110008#_b9141743_fd55_4fbe_a4af_176b300cdc32
type: Species
has only substance units: false
name: GGT7
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:2686
initial amount: NaN
is: A0PJJ9
is: SBO:0000252

metaM dlnlcgcrn m
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:16004
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
initial concentration: 1.0
name: dihomo-gamma-linolenyl carnitine
is: HMDB01311

metaR r1384
name: Guanosine aminohydrolase EC:3.5.4.15
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110008#
is: SBO:0000176
reactant: MODEL1310110008#
fast: false

metaM 34hpp e
boundary condition: false
is: HMDB00707
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
constant: false
type: Species
is: SBO:0000247
name: 3-(4-hydroxyphenyl)pyruvate
has only substance units: false
is: CHEBI:36242

metaM zym int2 r
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
constant: false
boundary condition: false
is: CHEBI:52386
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: zymosterol intermediate 2
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_a8fc19fc_f5a6_4120_84b7_85bd2e984eec
is: SBO:0000252
is encoded by: hsa:10587
name: TXNRD2
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_872bf290_fa37_4bdb_9ff9_7837b4fc2118
initial concentration: NaN
initial amount: NaN
name: AK2
is encoded by: hsa:204
boundary condition: true
has only substance units: false
type: Species
constant: false
is: SBO:0000252

metaM urea c
constant: false
name: Urea
is: C00086
type: Species
initial amount: NaN
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
boundary condition: false
is: SBO:0000247
is: HMDB00294
has only substance units: false
is: CHEBI:16199
initial concentration: 1.0

metaR FACOAL1812
reversible: true
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: fatty-acid--CoA ligase
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110008#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110008#_5cdb1f64_377c_4122_8a6e_dc652abbc78a
is: SBO:0000252
name: PLCG1
initial amount: NaN
is: P19174
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:5335
has only substance units: false

metaM HC01522 c
initial concentration: 1.0
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
boundary condition: false
is: SBO:0000247
type: Species
name: Gentisate aldehyde
is: CHEBI:28508
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_54e4512b_20b6_434b_a5e6_83a4149e2b47
type: Species
is encoded by: hsa:728226
initial amount: NaN
boundary condition: true
name: _728226_1_m
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252

metaR r0797
modifier: MODEL1310110008#
name: glycine N-choloyltransferase EC:2.3.1.65
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
reactant: MODEL1310110008#

metaR EX c10crn
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decanoyl carnitine
type: Reaction

metaM 3sala m
initial concentration: 1.0
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
is: CHEBI:61085
is: C00606
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
name: 3-sulfino-L-alanine (1-)
boundary condition: false

metaM HC01434 x
initial concentration: 1.0
constant: false
is: CHEBI:58931
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
boundary condition: false
name: oxalatosuccinate(3-)

http://identifiers.org/biomodels.db/MODEL1310110008#_3576083e_28c7_44a1_b183_5a594734bb4d
type: Species
is encoded by: hsa:5152
name: PDE9A
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_6ae6dd39_9675_44dc_ae4a_c5a8f49fe6bd
has only substance units: false
is encoded by: hsa:8706
boundary condition: true
name: B3GALNT1
initial amount: NaN
initial concentration: NaN
is: B3KTQ4
is: SBO:0000252
constant: false
type: Species

metaM ksi deg32 l
constant: false
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
is: SBO:0000247
has only substance units: false
is: CHEBI:12936
is: HMDB00143
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: keratan sulfate I, degradation product 32
type: Species

metaR RE3005M
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
name: RE3005
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110008#

metaR EX adn LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Adenosine
type: Reaction

metaM pan4p m
is: SBO:0000247
name: pantetheine 4'-phosphate(2-)
type: Species
is: CHEBI:47942
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB01416
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_ad208f2b_9c6b_4960_ba90_5d9108805388
name: MSMO1
is: A8MYF6
initial amount: NaN
is encoded by: hsa:6307
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_2fda5c09_b78c_4c73_b7a7_628565dab26f
is encoded by: hsa:64078
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
name: SLC28A3
is: Q9HAS3
has only substance units: false

metaR r0796
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110008#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110008#
product: MODEL1310110008#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_e379b720_04e4_4df7_a231_3b6cb74c119b
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q9GZS9
boundary condition: true
type: Species
is encoded by: hsa:23563
name: CHST5
has only substance units: false
initial amount: NaN

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

metaM 34hpp c
is: CHEBI:36242
is: HMDB00707
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
constant: false
has only substance units: false
name: 3-(4-hydroxyphenyl)pyruvate
boundary condition: false
is: SBO:0000247

metaR GCC2cm
reactant: MODEL1310110008#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.10
is described by: ECO:0000269
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.4.4.2
reversible: true
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
name: glycine-cleavage complex (lipoamide), mitochondrial

metaM urea e
initial amount: NaN
is: C00086
name: Urea
type: Species
is: SBO:0000247
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
boundary condition: false
is: HMDB00294
is: CHEBI:16199
constant: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_2e40d127_0f88_46b9_ad2e_13613f5474ce
type: Species
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5167
is: P22413
is: SBO:0000252
name: ENPP1
boundary condition: true

metaM 2dodtricoa m
initial amount: NaN
constant: false
type: Species
is: HMDB11123
has only substance units: false
boundary condition: false
is: SBO:0000247
name: 2,6,9-dodecatrienoylcoa
is: C05279
initial concentration: 1.0
notes: FORMULA: C33H48N7O17P3S CHARGE: -4

metaR DHEAtr
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.8.2.2 Confidence Level: 1 AUTHORS: PMID:11535246,PMID:1588921 NOTES:
reversible: true
product: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
type: Reaction
is described by: ECO:0000269
name: Dehydroepiandrosterone transport
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_f61cde5f_d76b_48fa_9fb6_d9389f8ed16a
name: PIK3C2B
type: Species
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: O00750
is: SBO:0000252
is encoded by: hsa:5287
initial amount: NaN

metaM h g
name: proton
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
constant: false
is: CHEBI:24636
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_58627acb_0551_495c_86e6_53834b05538e
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:55350
has only substance units: false
initial concentration: NaN
name: VNN3

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaM cholcoa c
initial amount: NaN
is: HMDB01374
initial concentration: 1.0
name: choloyl-CoA(4-)
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
is: CHEBI:57373
is: SBO:0000247
constant: false
has only substance units: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_4096664a_340e_4f47_9e67_f4f25b5c8581
has only substance units: false
is encoded by: hsa:6319
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
name: SCD
is: O00767

metaR GLYCLTtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
product: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
is described by: ECO:0000000
name: glycolate transport into peroxisome
type: Reaction
reactant: MODEL1310110008#
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110008#_09c7de50_d4de_4073_b248_f4fca7edd894
initial concentration: NaN
type: Species
name: ATP8A1
is: SBO:0000252
is: Q9Y2Q0
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:10396

http://identifiers.org/biomodels.db/MODEL1310110008#_8ac16a3c_0096_4c33_a0a3_638d535fa577
constant: false
boundary condition: true
initial amount: NaN
is: O14521
type: Species
initial concentration: NaN
name: SDHD
is encoded by: hsa:6392
has only substance units: false
is: SBO:0000252

metaM HC01434 m
name: oxalatosuccinate(3-)
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:58931
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
type: Species

metaM glc D c
constant: false
is: HMDB00122
is: CHEBI:4167
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false

metaR r2136
is: SBO:0000185
kinetic law: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
fast: false
modifier: MODEL1310110008#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6

metaM 3ivcrn c
is: HMDB06870
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: C05998
is: http://identifiers.org/pubchem.compound/11966188
type: Species
constant: false
has only substance units: false
notes: FORMULA: C12H23NO5 CHARGE: 0
boundary condition: false
name: 3-hydroxy-isovaleryl carnitine

metaM tmndnccoa c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
has only substance units: false
type: Species
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB06514
name: timnodonyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110008#_19240004_07bd_46c8_b734_462a1e0890d6
boundary condition: true
is encoded by: hsa:1503
is: SBO:0000252
type: Species
name: CTPS1
is: P17812
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_659dcce0_8a25_4929_8ab2_a47e523e0073
is: SBO:0000252
name: AK1
is: P00568
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:203
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_b87e6222_c68f_4be7_804a_906b6f2c7a44
initial amount: NaN
is encoded by: hsa:2629
name: GBA
boundary condition: true
type: Species
has only substance units: false
constant: false
is: B7Z6S1
is: SBO:0000252
initial concentration: NaN

metaR r0686
kinetic law: MODEL1310110008#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.2.2
product: MODEL1310110008#
is described by: ECO:0000000
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
fast: false
reactant: MODEL1310110008#
is: SBO:0000176
modifier: MODEL1310110008#
type: Reaction

metaR S6TASE11ly
fast: false
reversible: true
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
type: Reaction
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.6.14

metaM HC02202 e
name: prostaglandin A1(1-)
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:57398
type: Species
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
has only substance units: false

metaR r1654
is: SBO:0000185
modifier: MODEL1310110008#
reversible: true
reactant: MODEL1310110008#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110008#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR FADH2tx
product: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
type: Reaction
name: FADH2 transporter, peroxisomal
is described by: ECO:0000000
reactant: MODEL1310110008#
is: SBO:0000185
reversible: true

metaM ksi pre19 g
has only substance units: false
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
initial concentration: 1.0
type: Species
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 19
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
is: C00130
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110008#_80409ff1_38b0_4ef5_ad0c_0f243821b672
name: LPGAT1
boundary condition: true
initial concentration: NaN
type: Species
is: Q92604
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:9926
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110008#_cd18b717_012d_46f6_a235_16cec07a3225
initial amount: NaN
initial concentration: NaN
is: P59796
type: Species
name: GPX6
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:257202

metaR G14T16g
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110008#
fast: false
modifier: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_7b954efa_1a5a_4dea_9462_fb75ff44ec0a
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:2109
name: ETFA:ETFB
boundary condition: true
has part: P38117
constant: false
has only substance units: false
is: SBO:0000297

metaR HOCTDACBP
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyoctadecenoylcoa from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_62d43ce0_042d_444d_b2fc_f51e8a9e9750
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: MGAT1
type: Species
is encoded by: hsa:4245
constant: false
is: P26572
boundary condition: true
has only substance units: false

metaR CORE6GTg
is version of: http://identifiers.org/ec-code/2.4.1.102
fast: false
reactant: MODEL1310110008#
name: Core 6 beta-GlcNAc-transferase A, Golgi apparatus
product: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2650.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
reversible: false

metaR AG13T6g
reversible: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110008#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176

metaM pail4p hs n
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:58178
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
is: SBO:0000247
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
boundary condition: false
constant: false
has only substance units: false

metaR S6T1g
type: Reaction
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110008#
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110008#_a3623262_c606_4d9e_9ba5_c0b04e0cc8c7
is encoded by: hsa:5236
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
name: PGM1
is: B4DPV0
is: SBO:0000252

metaR RE2972M
is version of: http://identifiers.org/ec-code/2.7.1.67
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
fast: false
reactant: MODEL1310110008#
type: Reaction
name: RE2972
kinetic law: MODEL1310110008#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
modifier: MODEL1310110008#
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_951b1404_e2ef_433c_bf2d_ed5b6501a14c
is: Q9NQU1
boundary condition: true
initial concentration: NaN
name: SLC26A6
is encoded by: hsa:65010
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_85492e2d_8341_4bb3_9afb_9167add8d6b0
is: P07954
has only substance units: false
is encoded by: hsa:2271
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: FH
type: Species

metaR r2137
fast: false
kinetic law: MODEL1310110008#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110008#
is described by: ECO:0000000
modifier: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_18431f8f_7cb0_44ab_8587_89d0798e0efb
initial amount: NaN
is: SBO:0000252
name: _BE966236_1_c
has only substance units: false
constant: false
is encoded by: hsa:BE966236
type: Species
boundary condition: true
initial concentration: NaN

metaR r1653
kinetic law: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110008#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
modifier: MODEL1310110008#
is described by: ECO:0000000

metaR FAOXC11C9m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C11-->C9)m
type: Reaction

metaR 34HPPte
kinetic law: MODEL1310110008#
name: Transport of 3-(4-hydroxyphenyl)pyruvate
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000134

metaM retinal cis 13 r
type: Species
constant: false
is: CHEBI:45487
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: 13-cis-retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
boundary condition: false
is: HMDB06220

metaR FAOXC101m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

metaM 3hpp m
name: 3-hydroxypropionate
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: CHEBI:16510
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
is: HMDB00700
has only substance units: false
is: SBO:0000247

metaR LNLNCGt
product: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110008#
reversible: true
is: SBO:0000185
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110008#_40a1bb8f_b8c5_4d70_aca7_7d78222adccd
type: Species
boundary condition: true
has only substance units: false
name: _BE966236_1_m
is: SBO:0000252
is encoded by: hsa:BE966236
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_5c437ca4_b29d_4cda_aeaa_3d9cc0e98cf7
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:7378
constant: false
is: SBO:0000252
name: UPP1
is: Q16831
initial amount: NaN
boundary condition: true

metaR PIK3
is version of: http://identifiers.org/ec-code/2.7.1.153
kinetic law: MODEL1310110008#
name: phosphatidylinositol 3-kinase
reversible: false
product: MODEL1310110008#
fast: false
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.154
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.1.137

metaM glc D e
is: HMDB00122
initial amount: NaN
has only substance units: false
is: CHEBI:4167
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose
is: SBO:0000247
boundary condition: false
type: Species
constant: false

metaR r0295
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#
reversible: false
product: MODEL1310110008#
fast: false
name: glycine synthase Nitrogen metabolism EC:2.1.2.10

metaR HTDCACBP
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxytetradecanoyl-CoA from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_692820e7_ca7b_416f_8d05_6bf2c4968970
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:728441
boundary condition: true
name: GGT2
initial amount: NaN
is: SBO:0000252

metaM ethamp r
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: HMDB00224
initial concentration: 1.0
type: Species
constant: false
name: O-phosphonatoethanaminium(1-)
initial amount: NaN
is: CHEBI:58190

metaR r1656
reactant: MODEL1310110008#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
modifier: MODEL1310110008#
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110008#
is: SBO:0000185
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110008#_684b28f7_50f3_42d6_a165_b5a367b6f91e
name: _AA854479_1_m
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:AA854479

metaM glcur r
boundary condition: false
initial amount: NaN
is: HMDB00127
type: Species
name: D-glucuronate
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:15748
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_bdae774d_d60a_4bd5_9fa7_d212c64728a7
name: PANK3
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: Q9H999
is encoded by: hsa:79646
is: SBO:0000252
boundary condition: true
constant: false

metaR r0688
modifier: MODEL1310110008#
reversible: true
kinetic law: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
is: SBO:0000176
type: Reaction
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3

metaR SUCD1m
is: SBO:0000176
name: succinate dehydrogenase
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000134
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
is version of: http://identifiers.org/ec-code/1.3.5.1
kinetic law: MODEL1310110008#

metaM 2mb2coa m
name: 2-methylcrotonoyl-CoA(4-)
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
is: HMDB02054
initial concentration: 1.0
is: CHEBI:57337

http://identifiers.org/biomodels.db/MODEL1310110008#_eb581fde_7a75_4cb0_a867_8a6e2b3c3106
is: A0PJM6
is encoded by: hsa:1120
initial concentration: NaN
type: Species
constant: false
name: CHKB
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110008#_5df278c2_693d_4d18_8957_20be939052e2
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:8396
initial amount: NaN
type: Species
initial concentration: NaN
is: P78356
name: PIP4K2B

metaM 12ppd R c
boundary condition: false
initial concentration: 1.0
name: (R)-propane-1,2-diol
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
is: CHEBI:28972
constant: false
type: Species
is: HMDB01881
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR GLCSGLT1le
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-glucose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

metaR D3AIBTm
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110008#
product: MODEL1310110008#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
kinetic law: MODEL1310110008#
is: SBO:0000176
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial

metaR r1655
modifier: MODEL1310110008#
product: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaR r2139
modifier: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
kinetic law: MODEL1310110008#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM 34hpp m
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
name: 3-(4-hydroxyphenyl)pyruvate
constant: false
initial concentration: 1.0
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
is: CHEBI:36242
is: HMDB00707
type: Species

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_ddc625cc_c08d_4d54_b3c9_a407dfe9be7e
has part: Q8WYR1
type: Species
is: SBO:0000297
has only substance units: false
is encoded by: hsa:23533
name: PIK3R5:PIK3CG
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

metaR CSND
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#
name: Cytosine deaminase
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_92753e6e_2066_424e_a2cd_2c981d68c102
initial amount: NaN
is encoded by: hsa:3033
constant: false
type: Species
has only substance units: false
is: Q16836
name: HADH
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR N2M2NMASNtly
is described by: ECO:0000000
name: n2m2nmasn transport, extracellular to lysosome
product: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110008#
type: Reaction
reversible: false
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_22704def_771e_44cc_98ca_332bc9a8ade2
boundary condition: true
has only substance units: false
is: Q308M7
constant: false
type: Species
is encoded by: hsa:5169
name: ENPP3
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_a7d710d1_5ebe_412d_b0b2_ccc78a90dd71
type: Species
is: SBO:0000252
is encoded by: hsa:205
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
name: AK4

http://identifiers.org/biomodels.db/MODEL1310110008#_f5c50d63_5401_4504_9bff_8b9d533ac0ca
name: SCD5
constant: false
is encoded by: hsa:79966
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: Q86SK9

http://identifiers.org/biomodels.db/MODEL1310110008#_905258ab_0303_42c0_b813_34c524491516
is encoded by: hsa:9962
constant: false
initial amount: NaN
is: SBO:0000252
is: Q9UGH3
name: SLC23A2
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_1bedbfba_93e0_4778_88e3_b4ff9685b9df
is encoded by: hsa:2987
initial amount: NaN
is: SBO:0000252
name: GUK1
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: Q16774
boundary condition: true

metaM udpacgal g
is: CHEBI:57847
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: UDP-N-acetyl-D-galactosamine(2-)
is: HMDB00304
constant: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
boundary condition: false
type: Species
is: SBO:0000247

metaR r1650
modifier: MODEL1310110008#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110008#
fast: false
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110008#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_d990ce9e_67c9_496c_98f2_68095083f1c6
boundary condition: true
constant: false
type: Species
is encoded by: hsa:3417
has only substance units: false
initial amount: NaN
is: O75874
is: SBO:0000252
initial concentration: NaN
name: IDH1

metaR FAOXC225x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)x
type: Reaction

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaR ARACHDtr
kinetic law: MODEL1310110008#
product: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
is: SBO:0000185
name: intracellular transport
reversible: true
is described by: ECO:0000000
type: Reaction

metaR NACHEX17ly
reactant: MODEL1310110008#
is: SBO:0000176
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110008#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
fast: false
modifier: MODEL1310110008#

metaM sphings c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
is: CHEBI:57756
boundary condition: false
name: sphingosine(1+)
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: HMDB00252

http://identifiers.org/biomodels.db/MODEL1310110008#_524c58c6_f1f5_46ac_958f_ff9ce3648d32
is encoded by: hsa:AL048840
name: _AL048840_1_c
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

metaM 3hpcoa m
name: 3-hydroxypropanoyl-CoA(4-)
is: HMDB06807
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:58528
has only substance units: false
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668

metaR TCYNTt
type: Reaction
fast: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reversible: false
is: SBO:0000185
name: Thiocyanate transport via diffusion (cytosol to extracellular)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaM ficytC m
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
constant: false
initial concentration: 1.0
name: Ferricytochrome c
is: CHEBI:15991

http://identifiers.org/biomodels.db/MODEL1310110008#_ea84ff44_2455_4167_be7c_8238ea1193fe
type: Species
is encoded by: hsa:5152
boundary condition: true
initial concentration: NaN
name: PDE9A
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR ACETONEt2m
type: Reaction
product: MODEL1310110008#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000185
name: acetone mitochondrial transport via proton symport
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_4483c9b9_4744_4477_8949_1ad67179d049
name: ALDH1L1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:10840
constant: false
has only substance units: false
initial amount: NaN
is: O75891

metaR LTA4H
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/3.3.2.6
reversible: false
modifier: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
name: Leukotriene A-4 hydrolase
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110008#_0dcfc6b4_947d_4566_8ada_06c22b7e5afa
name: _AI640625_1_c
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI640625
constant: false

metaR UGALNACtg
product: MODEL1310110008#
fast: false
modifier: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
kinetic law: MODEL1310110008#
name: UDP-GalNAc Golgi transport via CMP antiport
is described by: ECO:0000269
reactant: MODEL1310110008#
type: Reaction
is: SBO:0000185

metaM hs deg11 l
has only substance units: false
type: Species
initial concentration: 1.0
name: heparan sulfate, degradation product 11
initial amount: NaN
is: HMDB00868
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C55H81N3O67S7 CHARGE: -8
is: CHEBI:57737

metaR r1652
fast: false
modifier: MODEL1310110008#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110008#
is: SBO:0000185
product: MODEL1310110008#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110008#
type: Reaction

metaR G6Pter
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD

metaM acnam c
is: CHEBI:35418
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: SBO:0000247
type: Species
name: N-acetylneuraminate
is: HMDB00230
initial amount: NaN
constant: false

metaM Ser Thr l
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00224
notes: FORMULA: XH CHARGE: 0
initial amount: NaN
is: CHEBI:58190
type: Species
name: protein-linked serine or threonine residue (O-glycosylation site)

metaR HS4ly
kinetic law: MODEL1310110008#
is: SBO:0000176
reversible: false
fast: false
name: heparan-N-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
product: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.10.1.1
is described by: ECO:0000000
reactant: MODEL1310110008#

metaM btamp m
is: SBO:0000247
initial concentration: 1.0
name: Biotinyl-5'-AMP
is: CHEBI:3110
type: Species
is: HMDB04220
boundary condition: false
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_ef0f4efb_2d83_43da_93f9_6118a316cd7c
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5464
is: Q15181
boundary condition: true
name: PPA1
type: Species
has only substance units: false

metaM lgt S c
name: (R)-S-lactoylglutathionate(1-)
initial amount: NaN
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
type: Species
is: CHEBI:57474
constant: false
is: SBO:0000247
is: HMDB01066
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR GLCNACASE5ly
modifier: MODEL1310110008#
type: Reaction
reversible: false
product: MODEL1310110008#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is: SBO:0000176
name: alpha-N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.2.1.50

metaR r0683
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
type: Reaction
product: MODEL1310110008#
reversible: false
reactant: MODEL1310110008#
is described by: ECO:0000000
modifier: MODEL1310110008#
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110008#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_98779926_c5b3_49bb_9b6f_dd780fc73f86
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:114112
type: Species
is: Q86VQ6
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: TXNRD3

metaR r1651
reactant: MODEL1310110008#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110008#
fast: false
product: MODEL1310110008#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110008#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110008#_0fadad49_b1ad_415e_a149_1a202de3ac18
is encoded by: hsa:5277
constant: false
name: PIGA
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_83d8a84a_e91c_4041_9651_457f4300f366
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
name: _AA203143_1_c
initial concentration: NaN
is encoded by: hsa:AA203143

metaR FAOXC101x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)x
type: Reaction

metaR r2141
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110008#
reversible: true
fast: false
kinetic law: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110008#_9788fc4f_2d07_40ab_a36d_a0572633d590
has only substance units: false
is: Q6IBB5
name: NDUFA1
constant: false
initial amount: NaN
is encoded by: hsa:4694
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR BTNt4i
name: Biotin uptake (antiport)
fast: false
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110008#
reversible: false
kinetic law: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
modifier: MODEL1310110008#
reactant: MODEL1310110008#

metaR FACOAL170
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
fast: false
type: Reaction
reversible: true
is: SBO:0000176
product: MODEL1310110008#
name: fatty-acid--CoA ligase
is described by: ECO:0000000
modifier: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_87f3eb59_b6af_4df2_b2e3_41903d59b0ae
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: GK
constant: false
is: P32189
is encoded by: hsa:2710
initial amount: NaN
boundary condition: true

metaM f1p c
has only substance units: false
is: CHEBI:18105
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB01076
name: D-Fructose 1-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00662 EHMN_ABBREVIATION: C01094
is: C01094
initial amount: NaN
constant: false
is: SBO:0000247

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaR S4TASE3ly
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.12
modifier: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
kinetic law: MODEL1310110008#
reversible: true

metaR FUCASE2e
is described by: ECO:0000000
product: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:10460218,PMID:11389735,PMID:12604617,PMID:2317201 NOTES:NCD
reactant: MODEL1310110008#
name: alpha-fucosidase, extracellular
kinetic law: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.51

http://identifiers.org/biomodels.db/MODEL1310110008#_596d0319_33e7_4cc0_ba83_3e74d3ceee49
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:4953
is: SBO:0000252
name: ODC1
boundary condition: true
is: P11926

metaM s2l2fn2m2masn e
name: PA6
is: SBO:0000247
notes: FORMULA: C90H145N6O65X CHARGE: -2
has only substance units: false
is: C00255
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00244
constant: false
initial concentration: 1.0
is: CHEBI:3554

metaM gam e
is: SBO:0000247
has only substance units: false
is: CHEBI:17315
is: C00329
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
constant: false
is: HMDB01514
name: D-Glucosamine
type: Species
initial concentration: 1.0

metaM glcur l
name: D-glucuronate
initial amount: NaN
is: HMDB00127
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:15748

http://identifiers.org/biomodels.db/MODEL1310110008#_a018fc2c_e1e6_4345_abf1_00d008a5fe26
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR r2140
fast: false
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110008#
product: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110008#

metaR IPDPtx
is described by: ECO:0000134
product: MODEL1310110008#
name: Isopentenyl diphosphate transport (peroxisome)
kinetic law: MODEL1310110008#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_7939d713_8a56_431d_9612_e467e3fe8fe2
initial concentration: NaN
initial amount: NaN
type: Species
is: Q99999
name: GAL3ST1
is: SBO:0000252
is encoded by: hsa:9514
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_6b86c1eb_10ec_482a_a002_0115f6bbd662
is encoded by: hsa:5315
name: PKM2
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P14618
type: Species
initial amount: NaN
is: SBO:0000252
constant: false

metaM ksi pre35 g
is: SBO:0000247
type: Species
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
constant: false
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 35
has only substance units: false
is: CHEBI:28067
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_0e52a0ea_44de_45c0_ad64_451955e771a9
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AF080579
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: _AF080579_1_c

http://identifiers.org/biomodels.db/MODEL1310110008#_993d8f83_8503_4f43_b038_3de8e7853871
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaM CE2424 m
type: Species
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
is: HMDB11123
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:28387
has only substance units: false

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

metaM HC01180 c
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-4-3(1-16-19(10,11)12)18-6(9,5(4)8)2-17-20(13,14)15/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C03785
is: SBO:0000247
type: Species
name: D-tagatofuranose 1,6-bisphosphate(4-)
initial concentration: 1.0
is: CHEBI:58694

metaR r0139
is version of: http://identifiers.org/ec-code/2.3.2.2
reversible: true
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
modifier: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110008#

metaM 3mox4hpac m
type: Species
has only substance units: false
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
is: CHEBI:28111
is: HMDB05175
initial concentration: 1.0
constant: false
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_c0ba78d9_76a9_4bbb_beda_9d9f985003e2
is: Q8TBG4
constant: false
initial concentration: NaN
is encoded by: hsa:64850
type: Species
name: AGXT2L1
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR PI345P3P
is described by: ECO:0000000
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.3.67
fast: false
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
product: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000176
modifier: MODEL1310110008#
type: Reaction
reversible: false

metaR PNTOte
fast: false
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is: SBO:0000185
name: Transport of (R)-Pantothenate
product: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
is described by: ECO:0000134

metaR GULN3D
is: SBO:0000176
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
reactant: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#
name: L-gulonate 3-dehydrogenase
kinetic law: MODEL1310110008#

metaM dpcoa e
type: Species
is: SBO:0000247
is: C00882
initial concentration: 1.0
initial amount: NaN
name: Dephospho-CoA
is: CHEBI:57328
is: HMDB01373
has only substance units: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
boundary condition: false
constant: false

metaR r2142
modifier: MODEL1310110008#
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
product: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110008#_d01d5344_573a_49d0_ba98_56339026364a
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:3419
initial amount: NaN
initial concentration: NaN
is: P50213
type: Species
name: IDH3A
is: SBO:0000252

metaR PI45P5P
fast: false
reactant: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.3.36
modifier: MODEL1310110008#
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase

metaM acnam n
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
type: Species
name: N-acetylneuraminate
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00230
initial concentration: 1.0
has only substance units: false
is: CHEBI:35418
is: SBO:0000247

metaR MMSAD3m
reversible: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.2.1.27
is: SBO:0000176
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
fast: false
product: MODEL1310110008#
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaR P45017A1r
fast: false
is described by: ECO:0000134
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.14.99.9
kinetic law: MODEL1310110008#
name: Cytochrome P450 17A1
reversible: false
notes: GENE_ASSOCIATION: (1586.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.99.9 Confidence Level: 4 AUTHORS: PMID:7893148 NOTES:cytosolic by default - RETURN AND CHECK AFTER DEEPER LIT SEARCH NJ. Kinetic studies conducted with recombinant e.coli transfected with human p450c17 with pregnenolone as substrate
is: SBO:0000176
reactant: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction

metaR GLCURtly
modifier: MODEL1310110008#
is described by: ECO:0000269
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
name: glucuronate transport into lysososme
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD

metaR FAOXTC182TC162m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C18:2-->C16:2)m
type: Reaction

metaR r2497
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
is: SBO:0000185
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110008#
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#

metaR CBR2
modifier: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.189
reversible: false
name: Carbonyl reductase [NADPH] 1
is described by: ECO:0000269
product: MODEL1310110008#
fast: false
type: Reaction
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ
kinetic law: MODEL1310110008#

metaM cmpacna c
type: Species
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial concentration: 1.0
boundary condition: false
name: CMP-N-acetyl-beta-neuraminate(2-)
constant: false
is: CHEBI:57812
initial amount: NaN
is: SBO:0000247
is: HMDB01176
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_bd705889_6c6d_4b01_8aee_0b29abfca92a
initial amount: NaN
boundary condition: true
name: ACHE
initial concentration: NaN
is encoded by: hsa:43
has only substance units: false
is: SBO:0000252
type: Species
constant: false
is: P22303

metaR r1657
type: Reaction
reversible: true
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
product: MODEL1310110008#
is: SBO:0000185
reactant: MODEL1310110008#

metaR RE1523M
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1523
modifier: MODEL1310110008#
product: MODEL1310110008#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaM hs deg7 l
has only substance units: false
name: heparan sulfate, degradation product 7
type: Species
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01352
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
is: SBO:0000247
is: CHEBI:17180

metaM ksii core2 pre6 g
is: SBO:0000247
constant: false
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 6
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C61H98N5O46SX CHARGE: -2

metaR r0463
reversible: true
reactant: MODEL1310110008#
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
kinetic law: MODEL1310110008#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_0630f5bd_7902_448c_9961_d3051d8dcd9a
has only substance units: false
is encoded by: hsa:1329
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q53YB7
initial concentration: NaN
constant: false
name: COX5B

metaR OCT11EFATP
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of vaccenic acid by cells
type: Reaction

metaM lac L x
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00190
has only substance units: false
is: SBO:0000247
is: CHEBI:16651
constant: false
name: (S)-lactate
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial amount: NaN

metaR PROSTGE2t
fast: false
type: Reaction
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
name: prostaglandin transport via bicarbonate countertransport
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
product: MODEL1310110008#
is described by: ECO:0000269
modifier: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_43ca82f3_ff61_4095_bb9c_c17a01ef6d82
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10599
constant: false
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: SLCO1B1
is: Q9Y6L6

metaM dtmp m
is: SBO:0000247
name: dTMP
type: Species
is: C00364
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
has only substance units: false
is: CHEBI:26999
initial amount: NaN
constant: false
boundary condition: false
is: HMDB01227
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_3f8d77dd_7a5f_474c_bbf6_c505a643f6f3
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: GUCY2D
is: Q02846
is encoded by: hsa:3000
has only substance units: false

metaR r1841
fast: false
product: MODEL1310110008#
type: Reaction
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110008#
modifier: MODEL1310110008#
reversible: false
is: SBO:0000185

metaR r1658
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110008#
reactant: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110008#
fast: false

metaR DOLPMT4 Uer
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000000
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
product: MODEL1310110008#
type: Reaction
reversible: false
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:

metaR CYSAMOe
product: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: CYSAMOe
type: Reaction
kinetic law: MODEL1310110008#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110008#_cb57df61_ba93_4f31_aa04_956fa18e7988
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5052
name: PRDX1
type: Species
has only substance units: false

metaR r0464
kinetic law: MODEL1310110008#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
reversible: true
reactant: MODEL1310110008#
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3

metaM acnam l
has only substance units: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: HMDB00230
constant: false
type: Species
is: CHEBI:35418
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: N-acetylneuraminate

http://identifiers.org/biomodels.db/MODEL1310110008#_73f6046d_75ef_4022_963d_2b189bad4221
boundary condition: true
is encoded by: hsa:38
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: ACAT1
is: P24752
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_a3c3f7dd_b92d_4b7b_837c_8fdfdc7a2a1f
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:765
name: CA6
boundary condition: true
initial concentration: NaN
is: Q5FC00
constant: false
is: SBO:0000252

metaM dpcoa l
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial amount: NaN
is: SBO:0000247
is: CHEBI:57328
name: 3'-dephospho-CoA(2-)
is: HMDB01373
constant: false

metaM Ser Thr g
type: Species
initial concentration: 1.0
name: protein-linked serine or threonine residue (O-glycosylation site)
constant: false
initial amount: NaN
is: HMDB00645
notes: FORMULA: XH CHARGE: 0
is: CHEBI:58336
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR DECCRNe
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydecanoyl carnitine into extra cellular space
type: Reaction

metaM didp c
boundary condition: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
type: Species
is: CHEBI:28823
is: HMDB03536
initial concentration: 1.0
name: dIDP
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247

metaR r1659
reversible: true
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110008#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110008#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_0a76231a_87ce_4959_8a8c_cc698a2b4cc1
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI924226
name: _AI924226_1_m
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_f57af538_7a90_4733_a63c_eca123fad0f9
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:522
type: Species
initial amount: NaN
is: SBO:0000297
has only substance units: false
initial concentration: NaN
boundary condition: true
has part: Q6NZ59

metaR r2380
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110008#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110008#
reversible: true
type: Reaction
reactant: MODEL1310110008#
fast: false
is: SBO:0000185

metaM hdcoa c
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
is: HMDB06532
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Hexadecenoyl-CoA (n-C16:1CoA)
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species

metaM h x
is: CHEBI:24636
type: Species
name: proton
has only substance units: false
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
is: C00080
initial amount: NaN

metaR r0570
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
is described by: ECO:0000000
reversible: true
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
is version of: http://identifiers.org/ec-code/6.3.3.2
modifier: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
product: MODEL1310110008#
is: SBO:0000176
type: Reaction

metaR FAOXC5OHc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: (3-hydroxyisovalerylcoa-->3-hydroxyisovalerylcarnitine)c
type: Reaction

metaM glcur e
is: CHEBI:15748
name: D-glucuronate
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
constant: false
is: HMDB00127
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_e2e8c89f_dbf8_4fdb_aa67_ee7b60504193
is: Q9UPR5
name: SLC8A2
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:6543
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false

metaR EX c16dc
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecanedioic acid mono-L-carnitine ester
type: Reaction

metaM tmndnccoa x
constant: false
is: SBO:0000247
is: HMDB06514
has only substance units: false
name: timnodonyl coenzyme A
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaR G14T17g
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110008#
reactant: MODEL1310110008#
reversible: false
fast: false
type: Reaction
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
kinetic law: MODEL1310110008#

metaR SADT
type: Reaction
modifier: MODEL1310110008#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.25
product: MODEL1310110008#
name: sulfate adenylyltransferase
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
reversible: false
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#

metaR DASPO1p
modifier: MODEL1310110008#
is: SBO:0000176
name: D-aspartate oxidase, peroxisomal
kinetic law: MODEL1310110008#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.3.1
type: Reaction
reversible: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (8528.2) or (8528.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 1.4.3.1 Confidence Level: 4 AUTHORS: PMID:12209855,PMID:9820813 NOTES:MM
product: MODEL1310110008#
fast: false

metaM tetpent6 e
boundary condition: false
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
name: tetracosapentaenoic acid, n-6
is: HMDB06322
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_2f18071b_ab46_4249_b07c_34e210e9d6f4
type: Species
has only substance units: false
is: P49902
is encoded by: hsa:22978
initial concentration: NaN
name: NT5C2
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false

metaM HC02202 c
is: CHEBI:57398
constant: false
name: prostaglandin A1(1-)
type: Species
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR r0571
is: SBO:0000176
name: (S)-Methylmalonyl-CoA hydrolase Propanoate metabolism EC:3.1.2.17
type: Reaction
reversible: true
reactant: MODEL1310110008#
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.5.1.8
is described by: ECO:0000000
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.17 Confidence Level: 0 AUTHORS: PMID:3071714,PMID:6885824 NOTES:
fast: false
kinetic law: MODEL1310110008#

metaR r0287
fast: false
modifier: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110008#
type: Reaction
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: false

metaM gam c
is: SBO:0000247
boundary condition: false
type: Species
is: C00329
is: CHEBI:17315
name: D-Glucosamine
initial amount: NaN
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB01514

metaM cmpacna g
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: HMDB01176
is: CHEBI:57812
type: Species
constant: false
initial amount: NaN
name: CMP-N-acetyl-beta-neuraminate(2-)
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR EX CE4722 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-casomorphin (1-6) exchange
type: Reaction

metaR RBK
product: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.15
name: ribokinase
is described by: ECO:0000304

metaR ACGALK
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110008#
reversible: false
type: Reaction
reactant: MODEL1310110008#
name: N-acetylgalactosamine kinase
is described by: ECO:0000000
product: MODEL1310110008#

metaM citr L m
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
name: L-citrulline
is: HMDB00904
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:16349

http://identifiers.org/biomodels.db/MODEL1310110008#_efe853fd_e340_4abd_b2f3_809671ece6f2
initial amount: NaN
initial concentration: NaN
name: ITPA
is: Q9BY32
is encoded by: hsa:3704
boundary condition: true
is: SBO:0000252
constant: false
type: Species
has only substance units: false

metaM hdcoa m
is: SBO:0000247
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
has only substance units: false
constant: false
is: HMDB06532
initial amount: NaN
name: Hexadecenoyl-CoA (n-C16:1CoA)
initial concentration: 1.0
boundary condition: false
type: Species

metaM dd3coa x
is: HMDB04257
boundary condition: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
has only substance units: false
type: Species
name: 3-dodecenoylcoa
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR GGH 10FTHF7GLUe
product: MODEL1310110008#
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
reactant: MODEL1310110008#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
is: SBO:0000176
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction

metaM glcur c
initial concentration: 1.0
is: SBO:0000247
name: D-glucuronate
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
constant: false
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:15748
is: HMDB00127

metaR 3DPHBH1
reactant: MODEL1310110008#
name: Hydroxylation of 3-Decaprenyl-4-hydroxybenzoate (NADH)
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212 NOTES:Used to make Ubiquinone-10 enzyme has not been identified yet. IT
is: SBO:0000176
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_8c00b9ae_16ae_45d0_8eba_9f2e8ed6395f
boundary condition: true
initial amount: NaN
is: Q86VV3
type: Species
name: ENTPD1
has only substance units: false
constant: false
is encoded by: hsa:953
is: SBO:0000252
initial concentration: NaN

metaM T4hcinnm m
is: HMDB02035
is: CHEBI:12876
notes: FORMULA: C9H7O3 CHARGE: -1 INCHI: InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/p-1/b6-3+ EHMN_ABBREVIATION: C00811
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
name: trans-4-coumarate
has only substance units: false
boundary condition: false

metaM h n
is: CHEBI:24636
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: proton
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
boundary condition: false

metaR S6TASE19ly
type: Reaction
modifier: MODEL1310110008#
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.6.14

http://identifiers.org/biomodels.db/MODEL1310110008#_2a36a155_c0b2_4a36_aff2_5684f0569cd2
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: SLC22A1
is: O15245
initial concentration: NaN
is encoded by: hsa:6580
constant: false
type: Species

metaR HSD3A2r
product: MODEL1310110008#
reactant: MODEL1310110008#
modifier: MODEL1310110008#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is version of: http://identifiers.org/ec-code/1.1.1.225
reversible: true
fast: false
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is: SBO:0000176
kinetic law: MODEL1310110008#
type: Reaction
is described by: ECO:0000000

metaR RE2625C
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
type: Reaction
name: RE2625
reversible: true

metaR r2382
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110008#
product: MODEL1310110008#
modifier: MODEL1310110008#
reactant: MODEL1310110008#
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_e2b9ab4f_5139_4cc4_9815_14211189295c
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: SULT1A3
is: P50224
boundary condition: true
constant: false
type: Species
is encoded by: hsa:6818
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_f25dc58f_65bb_4894_ade1_04f47b8d42e7
constant: false
has part: O95498
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8875
initial amount: NaN
type: Species
is encoded by: hsa:55350
is: SBO:0000297
boundary condition: true
name: VNN3:VNN2:VNN1

metaR BACCLm
is: SBO:0000176
product: MODEL1310110008#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/6.3.4.10
reversible: false
reactant: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
fast: false
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial

metaM CE2431 m
is: SBO:0000247
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
type: Species
initial amount: NaN
name: cis-deca-4-enoyl-CoA
is: CHEBI:57795
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR r1377
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110008#
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
is: SBO:0000176
reversible: true
fast: false
product: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110008#

metaR PDX5PO
kinetic law: MODEL1310110008#
product: MODEL1310110008#
modifier: MODEL1310110008#
name: pyridoxine 5'-phosphate oxidase
is version of: http://identifiers.org/ec-code/1.4.3.5
reversible: true
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES:NCD
is: SBO:0000176
fast: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110008#

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

metaR r1950
is: SBO:0000185
kinetic law: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
reversible: false
product: MODEL1310110008#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
modifier: MODEL1310110008#

metaR r2385
fast: false
modifier: MODEL1310110008#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
product: MODEL1310110008#
reversible: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110008#_03e22976_5cf2_4a02_bbfb_64e714819ba3
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2876
initial concentration: NaN
has only substance units: false
type: Species
name: GPX1
constant: false

metaR MM6bg
kinetic law: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is version of: http://identifiers.org/ec-code/3.2.1.113
reversible: false
fast: false
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
product: MODEL1310110008#

metaM dpcoa m
boundary condition: false
constant: false
type: Species
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57328
name: 3'-dephospho-CoA(2-)
is: HMDB01373
is: SBO:0000247
has only substance units: false

metaR NACHEX23ly
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
reversible: false
kinetic law: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110008#

metaM 5aizc c
initial amount: NaN
has only substance units: false
is: C04751
boundary condition: false
constant: false
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
is: SBO:0000247
is: CHEBI:58564
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
initial concentration: 1.0
is: HMDB06273
type: Species

metaR ALADGLYexR
modifier: MODEL1310110008#
is described by: ECO:0000304
type: Reaction
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110008#
name: D-alanine/glycine reversible exchange
kinetic law: MODEL1310110008#
reversible: true
is: SBO:0000185
fast: false

metaR r1374
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110008#
name: EC:3.2.1.14
reversible: false
is: SBO:0000176
product: MODEL1310110008#

metaR IDOAASE4ly
name: alpha-L-iduronidase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.76
fast: false
reactant: MODEL1310110008#
modifier: MODEL1310110008#
reversible: false
kinetic law: MODEL1310110008#
is: SBO:0000176
product: MODEL1310110008#
type: Reaction

metaM asp L m
constant: false
initial concentration: 1.0
is: HMDB00191
is: CHEBI:29991
name: L-aspartate(1-)
is: SBO:0000247
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false

metaM h l
name: proton
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
boundary condition: false
is: C00080
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: "
is: CHEBI:24636

http://identifiers.org/biomodels.db/MODEL1310110008#_fba3d203_3fa5_449b_8923_7a49dcb90cc1
is: P48735
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: IDH2
type: Species
is encoded by: hsa:3418

metaR r2384
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110008#
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
fast: false
modifier: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110008#_c1ac15d7_6cd8_4e26_b127_afc86a1be23e
initial concentration: NaN
name: PDE9A
initial amount: NaN
is encoded by: hsa:5152
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_395a1610_d4e1_4d62_9acd_d8a5a453d02d
type: Species
is encoded by: hsa:2752
is: SBO:0000252
name: GLUL
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: P15104
initial amount: NaN

metaM ura e
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: CHEBI:17568
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
name: uracil
type: Species
is: HMDB00300
initial amount: NaN
has only substance units: false

metaR FBA2
modifier: MODEL1310110008#
is described by: ECO:0000304
reactant: MODEL1310110008#
fast: false
type: Reaction
is: SBO:0000176
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/4.1.2.13
reversible: true
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110008#

metaM ksi deg12 l
constant: false
is: HMDB00143
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
is: SBO:0000247
type: Species
has only substance units: false
name: keratan sulfate I, degradation product 12
is: CHEBI:12936

metaR ELAIDCRNt
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110008#
name: transport into the mitochondria (carnitine)
is: SBO:0000185
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110008#
modifier: MODEL1310110008#
product: MODEL1310110008#
fast: false

metaR PPAt
kinetic law: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
is: SBO:0000185
product: MODEL1310110008#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
is described by: ECO:0000000
type: Reaction
name: Propionate transport, diffusion

metaR Uritm
name: uridine facilated transport in mitochondria
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
product: MODEL1310110008#
is: SBO:0000185
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000269
modifier: MODEL1310110008#

metaR NAt
kinetic law: MODEL1310110008#
is described by: ECO:0000269
reactant: MODEL1310110008#
reversible: true
name: sodium transport (uniport)
modifier: MODEL1310110008#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6526.1) or (6523.1) or (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:1372904,PMID:15546855,PMID:2490366,PMID:7537337,PMID:7789985,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:
type: Reaction
fast: false
product: MODEL1310110008#

metaM fru e
initial amount: NaN
name: D-Fructose
initial concentration: 1.0
constant: false
is: C00095
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
type: Species
is: HMDB00660
boundary condition: false
is: SBO:0000247
is: CHEBI:15824

metaR r0130
reactant: MODEL1310110008#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
type: Reaction
product: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
reversible: true

metaR r1375
is described by: ECO:0000000
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110008#
name: Transport reaction
type: Reaction
reversible: false
kinetic law: MODEL1310110008#

metaM h m
type: Species
is: C00080
constant: false
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: proton

metaR SUCCtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
name: succinate transporter, peroxisome
reactant: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
reversible: true

metaR r0575
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.1.48
is described by: ECO:0000000
fast: false
reactant: MODEL1310110008#
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
reversible: true
is: SBO:0000176
modifier: MODEL1310110008#
type: Reaction

metaR DGSNtm
reversible: true
type: Reaction
reactant: MODEL1310110008#
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110008#
name: deoyguanosine transport in mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:3696164 NOTES:
product: MODEL1310110008#

metaM undcoa m
name: undecanoylcoa
notes: FORMULA: C32H52N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
is: HMDB13114
boundary condition: false

metaR RE2349C
fast: false
product: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
type: Reaction
name: RE2349
is version of: http://identifiers.org/ec-code/2.6.1.64
is: SBO:0000176
reactant: MODEL1310110008#
modifier: MODEL1310110008#
reversible: true
kinetic law: MODEL1310110008#

metaM CE5162 r
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:57923
initial amount: NaN
name: trans,cis-2,9-octadecadienoyl-CoA
boundary condition: false

metaR r2387
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
product: MODEL1310110008#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110008#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110008#
is: SBO:0000185
modifier: MODEL1310110008#

metaM s2l2n2m2mn l
constant: false
initial concentration: 1.0
boundary condition: false
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00573
notes: FORMULA: C76H123N5O57 CHARGE: -2
is: CHEBI:30825
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_bda28a78_b658_419d_88b1_190c1614404e
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
name: SLC9A1
constant: false
is encoded by: hsa:6548
is: P19634
boundary condition: true
initial concentration: NaN

metaR PACCOAL
type: Reaction
product: MODEL1310110008#
is: SBO:0000176
name: phenylacetate-CoA ligase
kinetic law: MODEL1310110008#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
reversible: false

metaM dtmp e
is: CHEBI:26999
constant: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
name: dTMP(2-)
is: HMDB01227
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

metaR SPMTDe
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
reversible: true
product: MODEL1310110008#
name: SPMTDe
reactant: MODEL1310110008#
is described by: ECO:0000134
fast: false
is: SBO:0000185

metaM h r
initial amount: NaN
is: C00080
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
has only substance units: false
is: CHEBI:24636
name: proton
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3380
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_559842cb_120e_43fd_a178_50734bbe8c01
is: O00462
initial concentration: NaN
name: MANBA
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:4126
boundary condition: true

metaM 5mta e
notes: FORMULA: C11H15N5O3S CHARGE: 0
is: CHEBI:17509
is: HMDB01173
name: 5-Methylthioadenosine
initial concentration: 1.0
is: C00170
type: Species
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247

metaM 3octdece1coa c
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
is: HMDB13336
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
name: 3-hydroxyoctadecenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110008#_9ff3116d_6d3a_4f49_a480_89076cb73e95
boundary condition: true
has only substance units: false
is: Q11201
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
name: ST3GAL1
is encoded by: hsa:6482
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_3cd650c6_2b47_4510_81b6_ad28c21d5b08
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q11203
has only substance units: false
constant: false
is encoded by: hsa:6487
boundary condition: true
name: ST3GAL3

metaR FBA4
is version of: http://identifiers.org/ec-code/4.1.2.13
notes: GENE_ASSOCIATION: (226.2) or (229.1) or (226.3) or (230.1) or (226.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.2.13 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
product: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
type: Reaction
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
is: SBO:0000176
kinetic law: MODEL1310110008#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110008#

metaR r2386
is described by: ECO:0000000
kinetic law: MODEL1310110008#
fast: false
reversible: false
is: SBO:0000185
modifier: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110008#

metaM ura c
is: CHEBI:17568
is: SBO:0000247
initial amount: NaN
constant: false
is: C00106
has only substance units: false
initial concentration: 1.0
is: HMDB00300
name: Uracil
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
type: Species
boundary condition: false

metaR O2t
fast: false
product: MODEL1310110008#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
reactant: MODEL1310110008#
reversible: true
name: o2 transport (diffusion)
is described by: ECO:0000000

metaR TETHEX3t
kinetic law: MODEL1310110008#
is described by: ECO:0000000
name: fatty acid transport via diffusion
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110008#
is: SBO:0000185
product: MODEL1310110008#
reversible: true

metaM octdececrn c
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0
constant: false
type: Species
boundary condition: false
is: HMDB06351
initial amount: NaN
initial concentration: 1.0
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_b11ce568_2045_4269_81fe_cf1ddcc95124
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:218
boundary condition: true
is: P30838
constant: false
type: Species
name: ALDH3A1
initial concentration: NaN

metaM tetpent3 e
type: Species
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: HMDB06323
is: SBO:0000247
name: tetracosapentaenoic acid, n-3
initial concentration: 1.0
boundary condition: false

metaM fru c
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
is: C00095
type: Species
is: HMDB00660
has only substance units: false
name: D-Fructose
is: CHEBI:15824
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
boundary condition: false

metaR GLYSNAT5tc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM dadp n
name: dADP(3-)
initial concentration: 1.0
is: HMDB01508
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: CHEBI:57667

metaM 44mctr r
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB01023
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
has only substance units: false
constant: false
is: CHEBI:17813
initial concentration: 1.0
initial amount: NaN

metaR r2389
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
fast: false
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110008#

metaR r1378
type: Reaction
is described by: ECO:0000000
product: MODEL1310110008#
reversible: true
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
reactant: MODEL1310110008#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
kinetic law: MODEL1310110008#

metaR XOL7AH2tm
reversible: true
type: Reaction
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110008#
is: SBO:0000185
fast: false
reactant: MODEL1310110008#
product: MODEL1310110008#

metaM cmpacna n
boundary condition: false
is: CHEBI:57812
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
name: CMP-N-acetyl-beta-neuraminate(2-)
is: HMDB01176
has only substance units: false

metaR r0578
product: MODEL1310110008#
modifier: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/4.1.2.27
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is described by: ECO:0000000

metaM 3octpencoa m
name: 3,6,9,12,15-octadecapentenoylcoa
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false
initial amount: NaN
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
initial concentration: 1.0

metaM malthx e
initial concentration: 1.0
name: Maltohexaose
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
type: Species
constant: false
is: SBO:0000247
is: C01936
initial amount: NaN
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041

metaM dtmp c
has only substance units: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
type: Species
name: dTMP
is: CHEBI:26999
is: SBO:0000247
is: C00364
constant: false
initial concentration: 1.0
is: HMDB01227
initial amount: NaN
boundary condition: false

metaR IDOAASE1ly
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
type: Reaction
reversible: false
kinetic law: MODEL1310110008#
is: SBO:0000176
fast: false
product: MODEL1310110008#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.76
reactant: MODEL1310110008#
modifier: MODEL1310110008#
name: alpha-L-iduronidase, lysosomal

metaM bamppald c
is: HMDB01106
is: http://identifiers.org/pubchem.compound/7975
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
is: C05665
initial amount: NaN
name: beta-Aminopropion aldehyde
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_9a0eb024_1a18_4f05_8fb5_bffd46ceb348
is: B3KN25
is encoded by: hsa:10390
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
name: CEPT1
initial amount: NaN

metaR C10CRNe
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decanoyl carnitine into extra cellular space
type: Reaction

metaR G3PD2m
kinetic law: MODEL1310110008#
name: glycerol-3-phosphate dehydrogenase (FAD), mitochondrial
notes: GENE_ASSOCIATION: (2820.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.99.5 Confidence Level: 2 AUTHORS: PMID:11385633,PMID:8549872 NOTES:replaces old version which contains redundant metabolite (gly3p) NCD split compartmentation NJ
is version of: http://identifiers.org/ec-code/1.1.5.3
reactant: MODEL1310110008#
type: Reaction
is described by: ECO:0000304
product: MODEL1310110008#
modifier: MODEL1310110008#
is: SBO:0000185
reversible: false
fast: false

metaR r2388
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
kinetic law: MODEL1310110008#
is: SBO:0000185
reversible: false
type: Reaction
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000000
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR GTHP
is described by: ECO:0000134
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.11.1.15
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.11.1.12
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
fast: false
product: MODEL1310110008#
name: glutathione peroxidase
type: Reaction
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.11.1.9

metaR r0579
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
modifier: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#
reversible: true
fast: false
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is version of: http://identifiers.org/ec-code/1.13.11.19
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_39035c1b_3714_4edf_9d60_f8645e198c8b
initial amount: NaN
is: A8K8P8
has only substance units: false
constant: false
is: SBO:0000252
type: Species
name: FUT8
boundary condition: true
is encoded by: hsa:2530
initial concentration: NaN

metaR GTHO
fast: false
is: SBO:0000176
kinetic law: MODEL1310110008#
product: MODEL1310110008#
modifier: MODEL1310110008#
name: glutathione oxidoreductase
is described by: ECO:0000254
type: Reaction
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
is version of: http://identifiers.org/ec-code/1.8.1.7
reversible: false
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_32bb78ce_89b0_4a3b_b540_58c96b6f3624
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q67FW5
initial amount: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:146712
name: B3GNTL1

http://identifiers.org/biomodels.db/MODEL1310110008#_77b904a0_b8cc_4870_bf0c_d68a3d52f2f4
is: SBO:0000252
is: Q7KZA3
boundary condition: true
type: Species
constant: false
has only substance units: false
name: FECH
initial concentration: NaN
is encoded by: hsa:2235
initial amount: NaN

metaM tetpent3 c
has only substance units: false
type: Species
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial amount: NaN
name: tetracosapentaenoic acid, n-3
constant: false
is: HMDB06323
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_4d776098_a5c2_4e49_8987_976d84840dbe
constant: false
boundary condition: true
name: GGT3P
is encoded by: hsa:2679
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110008#_1ffaa3c0_76e3_4789_a969_c93a3cfaddf1
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: ACSS1
is encoded by: hsa:84532
type: Species
is: Q9NUB1
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_6e050107_bdeb_4d41_b71d_a3e06ca6a08e
is: SBO:0000252
boundary condition: true
name: B3GNT6
initial amount: NaN
is encoded by: hsa:192134
type: Species
has only substance units: false
is: A8K9Q8
initial concentration: NaN
constant: false

metaM mi1345p c
initial amount: NaN
is: HMDB01059
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
boundary condition: false
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
is: SBO:0000247
type: Species
constant: false
is: CHEBI:57895
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_74cc17b0_987f_4b53_b88c_97d6adb4d1e4
is encoded by: hsa:1120
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: CHKB
boundary condition: true
type: Species
initial amount: NaN
is: Q9Y259

http://identifiers.org/biomodels.db/MODEL1310110008#_9ccb4183_dd5e_439a_afa7_229738e4a065
boundary condition: true
type: Species
name: CRAT
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:1384
initial amount: NaN

metaR r1797
fast: false
product: MODEL1310110008#
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110008#
is described by: ECO:0000000
reversible: false
name: Y+LAT2 Utilized transport

metaM prostge1 c
is: HMDB01442
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
initial amount: NaN
is: CHEBI:57397
is: SBO:0000247
initial concentration: 1.0
name: prostaglandin E1(1-)
constant: false

metaM udp m
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: HMDB00295
is: CHEBI:58223
initial amount: NaN
boundary condition: false
has only substance units: false
name: UDP(3-)
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_0dbab50c_e36f_43f0_9d7c_a61478b6bb8f
name: PIK3C2G
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:5288
is: SBO:0000252
is: O75747
type: Species

metaR ACNAMtn
product: MODEL1310110008#
is: SBO:0000185
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
reversible: false
is described by: ECO:0000000
fast: false
type: Reaction
name: N-acetylneuraminate nuclear import
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM hpdcacrn c
name: heptadecanoyl carnitine
is: SBO:0000247
has only substance units: false
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
boundary condition: false
is: HMDB06210
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false

metaR UAG4E
name: UDP-N-acetylglucosamine 4-epimerase
reversible: true
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/5.1.3.2
is: SBO:0000176
modifier: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110008#

metaR C204CRNt
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
is: SBO:0000185
fast: false
product: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110008#
reversible: false
name: arachidonic acid transport into the mitochondria

http://identifiers.org/biomodels.db/MODEL1310110008#_250670ff_c77b_4c51_b7bb_46b1b8253f34
constant: false
is encoded by: hsa:516
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: ATP5G1
is: Q6FIH7
boundary condition: true
type: Species

metaR NACHEX18ly
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
type: Reaction
reversible: false
product: MODEL1310110008#
modifier: MODEL1310110008#
is: SBO:0000176
kinetic law: MODEL1310110008#
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR KSIt
is described by: ECO:0000000
fast: false
product: MODEL1310110008#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
is: SBO:0000185
name: keratan sulfate I transport, golgi to extracellular

metaR S4TASE2ly
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.12
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
reactant: MODEL1310110008#
fast: false
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is described by: ECO:0000000
is: SBO:0000176

metaM r5p r
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
name: alpha-D-Ribose 5-phosphate
is: CHEBI:18189
is: HMDB00618
constant: false

metaR LINKDEG4ly
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
reactant: MODEL1310110008#
reversible: false
is: SBO:0000176
name: degradation of proteoglycan linkage region, lysosomal
type: Reaction

metaM ksi e
is: HMDB00211
is: SBO:0000247
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
boundary condition: false
has only substance units: false
is: CHEBI:17268
initial amount: NaN
name: keratan sulfate I
initial concentration: 1.0
constant: false
type: Species

metaR HSD3B7P
fast: false
reversible: false
is described by: ECO:0000269
name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
kinetic law: MODEL1310110008#
is: SBO:0000176
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.181
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110008#
type: Reaction

metaM udp n
is: CHEBI:58223
name: UDP(3-)
type: Species
is: HMDB00295
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_697e7be6_4326_49f6_8bbf_fd1d286d4350
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: PDE9A
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:5152

metaR G5SDym
type: Reaction
reversible: false
product: MODEL1310110008#
modifier: MODEL1310110008#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110008#
name: glutamate-5-semialdehyde dehydrogenase (m)
is version of: http://identifiers.org/ec-code/1.2.1.41
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 1.2.1.41 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m TDV: name change from G5SDm
is described by: ECO:0000254

metaM 5mta c
boundary condition: false
is: CHEBI:17509
is: SBO:0000247
is: HMDB01173
constant: false
initial amount: NaN
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
has only substance units: false
type: Species
name: 5-Methylthioadenosine
is: C00170
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_ac18526b_0d3a_4de9_bbed_9f72f9720241
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: PANK2
initial amount: NaN
is encoded by: hsa:80025
boundary condition: true
type: Species

metaM pail345p hs c
has only substance units: false
is: CHEBI:57836
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
is: SBO:0000247
type: Species
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)

metaR UMPK2n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
product: MODEL1310110008#
is: SBO:0000176
reversible: true
modifier: MODEL1310110008#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
name: UMP kinase (CTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110008#_e057deca_c1bd_486b_8bfb_f91ffcc9e1cb
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is: O75521
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10455
has only substance units: false
name: ECI2

metaR EHGLATm
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
is: SBO:0000176
reactant: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
is described by: ECO:0000212
type: Reaction
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#

metaM mercplaccys e
boundary condition: false
name: 3-mercaptolactate-cysteine disulfide
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB06512
constant: false

metaM glu L c
type: Species
initial concentration: 1.0
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: HMDB00148
is: SBO:0000247
has only substance units: false
is: CHEBI:29985
initial amount: NaN
constant: false
boundary condition: false
name: L-glutamate(1-)

metaM lac L e
is: SBO:0000247
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
name: (S)-lactate
is: HMDB00190
is: CHEBI:16651
initial concentration: 1.0

metaM prostge1 e
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: SBO:0000247
is: CHEBI:57397
constant: false
initial concentration: 1.0
is: HMDB01442
name: prostaglandin E1(1-)
type: Species

metaM CE5119 m
constant: false
name: trans-3-cis-8-tetradecadienoyl-CoA
type: Species
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:57923
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_62482f6b_9041_4b5c_a965_d1aff53665c2
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:3948
name: LDHC
is: SBO:0000252
initial concentration: NaN
type: Species

metaM c10crn c
type: Species
initial concentration: 1.0
is: HMDB00651
boundary condition: false
name: decanoyl carnitine
notes: FORMULA: C17H33NO4 CHARGE: 0
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_35f5f572_7d9f_4eca_8c9b_2ab68f62839a
is encoded by: hsa:51109
boundary condition: true
is: B4DDW0
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
name: RDH11

http://identifiers.org/biomodels.db/MODEL1310110008#_708c7edb_740c_417c_b145_0f1c9b8ac6ee
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: _MBOAT5_1_c
is: SBO:0000252
is encoded by: hsa:MBOAT5
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_924135e8_23b8_45e7_bbb8_499da6eed32a
initial concentration: NaN
name: CPT2
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is: P23786
boundary condition: true
is encoded by: hsa:1376

metaR PPAn
fast: false
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reversible: false
name: inorganic diphosphatase, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_206dafd9_cded_4404_9cf4_ed43283820bc
constant: false
is: Q3KQV9
initial concentration: NaN
initial amount: NaN
name: UAP1L1
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:91373
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110008#_0507cf10_b8ef_44b9_9cf3_4f8006bcb6f2
has only substance units: false
boundary condition: true
is encoded by: hsa:522
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial amount: NaN
is: SBO:0000297
type: Species
has part: Q6IB54
constant: false

metaM ksi deg19 l
has only substance units: false
is: CHEBI:57455
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
name: keratan sulfate I, degradation product 19
initial concentration: 1.0
notes: FORMULA: C146H236N10O124S6 CHARGE: -6
is: HMDB01354

http://identifiers.org/biomodels.db/MODEL1310110008#_20845181_26b3_42b2_a29a_051a9e85987a
is: Q96N66
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:79143
initial concentration: NaN
is: SBO:0000252
name: MBOAT7
constant: false
initial amount: NaN

metaM ins c
boundary condition: false
is: C00294
initial concentration: 1.0
is: HMDB00195
is: CHEBI:17596
name: Inosine
constant: false
initial amount: NaN
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: SBO:0000247
has only substance units: false
type: Species

metaR EX CE4724 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: apelin (1-12) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_c5381e5d_a48e_4c0b_b23f_d83acd27a4f9
boundary condition: true
has only substance units: false
name: _AI971036_1_m
is encoded by: hsa:AI971036
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
initial concentration: NaN

metaR LNELDCCPT2
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110008#
product: MODEL1310110008#
name: carnitine transferase
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR EX oxa LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

metaR FAOXC14C14OHm
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C14OH)m
type: Reaction

metaM man1p c
is: HMDB06330
is: SBO:0000247
is: CHEBI:35374
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
name: D-Mannose 1-phosphate

metaM didp n
is: SBO:0000247
is: HMDB03536
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
type: Species
has only substance units: false
is: CHEBI:28823
initial amount: NaN
name: dIDP

metaR EX 3tetd7ecoacrn
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy tetradecenoyl-7-carnitine
type: Reaction

metaM lac L c
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: (S)-lactate
initial concentration: 1.0
is: HMDB00190
constant: false
is: CHEBI:16651
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177

metaR PRAGSr
is: SBO:0000176
name: phosphoribosylglycinamide synthase
product: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110008#
reversible: true
is version of: http://identifiers.org/ec-code/2.1.2.2
reactant: MODEL1310110008#

metaR TSTSTERONEt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110008#
is: SBO:0000185
reactant: MODEL1310110008#
name: Testosterone transport
product: MODEL1310110008#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_0d13c5f1_079d_4a0a_a367_0c6cddebdeb2
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: O75747
name: PIK3C2G
boundary condition: true
is encoded by: hsa:5288

metaR RE0583C
type: Reaction
kinetic law: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000176
name: RE0583
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:

metaM c10crn e
is: HMDB00651
initial concentration: 1.0
initial amount: NaN
name: decanoyl carnitine
boundary condition: false
notes: FORMULA: C17H33NO4 CHARGE: 0
is: SBO:0000247
has only substance units: false
type: Species
constant: false

metaR CYTK9
modifier: MODEL1310110008#
type: Reaction
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110008#
product: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,dCTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110008#
is: SBO:0000176

metaR RE2973N
modifier: MODEL1310110008#
product: MODEL1310110008#
name: RE2973
is version of: http://identifiers.org/ec-code/2.7.1.154
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110008#
type: Reaction
is: SBO:0000176
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_0633a902_0aec_4402_8e71_71b882eb2e95
is: P27338
initial concentration: NaN
boundary condition: true
constant: false
name: MAOB
is: SBO:0000252
is encoded by: hsa:4129
initial amount: NaN
type: Species
has only substance units: false

metaR FACOAL1821
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE1514C
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
fast: false
name: fatty-acid--CoA ligase
reversible: true
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000269
is: SBO:0000176

metaM xoltetrol c
boundary condition: false
initial concentration: 1.0
is: HMDB01231
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
initial amount: NaN
is: CHEBI:17278
type: Species

metaM udp r
name: UDP
boundary condition: false
has only substance units: false
is: CHEBI:58223
is: C00015
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
constant: false
is: HMDB00295
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR VACCCPT2
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110008#
reversible: false
type: Reaction
reactant: MODEL1310110008#
name: carnitine transferase
kinetic law: MODEL1310110008#
product: MODEL1310110008#

metaM ins e
is: CHEBI:17596
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
name: Inosine
initial amount: NaN
type: Species
is: C00294
is: HMDB00195
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: SBO:0000247

metaR NDPK5n
reversible: true
product: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
kinetic law: MODEL1310110008#
is described by: ECO:0000304
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
reactant: MODEL1310110008#

metaM lneldc e
is: HMDB06270
constant: false
initial concentration: 1.0
has only substance units: false
name: linoelaidic acid (all trans C18:2)
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
is: SBO:0000247

metaM ivcrn e
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB00688
name: isovaleryl carnitine
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C12H23NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110008#_7a7055a7_d47f_4642_8631_8116b33c1cc6
initial concentration: NaN
constant: false
is: Q9NQR4
is encoded by: hsa:56954
has only substance units: false
boundary condition: true
is: SBO:0000252
name: NIT2
type: Species
initial amount: NaN

metaM so3 m
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: CHEBI:17137
type: Species
has only substance units: false
boundary condition: false
is: HMDB00240
initial amount: NaN
name: hydrogensulfite

metaR HEX4
is described by: ECO:0000304
product: MODEL1310110008#
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
reversible: false
reactant: MODEL1310110008#
name: hexokinase (D-mannose:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.2
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.1
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975

http://identifiers.org/biomodels.db/MODEL1310110008#_f45d8620_8695_4a05_b7b3_1ba86d78ce65
name: TSTA3
initial amount: NaN
is encoded by: hsa:7264
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is: Q13630
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_594693b5_3ef7_4d81_8b33_73259eeeb692
boundary condition: true
is: Q9NY65
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1962
initial amount: NaN
name: EHHADH

metaR VACCCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
reversible: false
product: MODEL1310110008#
is: SBO:0000176
name: carnitine O-palmitoyltransferase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
type: Reaction
reactant: MODEL1310110008#

metaM o2s e
boundary condition: false
initial concentration: 1.0
name: superoxide
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: HMDB02168
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:18421
is: SBO:0000247

metaR FACOAL1822
is described by: ECO:0000269
name: fatty-acid--CoA ligase
is: SBO:0000176
product: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
reactant: MODEL1310110008#
type: Reaction
fast: false
kinetic law: MODEL1310110008#

metaR LNELDCCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
type: Reaction
reactant: MODEL1310110008#
reversible: false
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000176
name: carnitine O-palmitoyltransferase

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaM ksii core2 deg5 l
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB00143
initial amount: NaN
notes: FORMULA: C50H82N4O38SX CHARGE: -1
type: Species
boundary condition: false
is: CHEBI:12936
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 5

http://identifiers.org/biomodels.db/MODEL1310110008#_4cda1875_dd72_4147_828a_be1c32b01293
constant: false
initial concentration: NaN
is encoded by: hsa:8876
name: VNN1
is: SBO:0000252
boundary condition: true
has only substance units: false
is: O95497
type: Species
initial amount: NaN

metaR EICOSTETCRNt
reactant: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: transport into the mitochondria (carnitine)
reversible: false
type: Reaction
product: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_5d59368c_a4b7_4b80_8ae1_7e140a70a6f8
constant: false
initial concentration: NaN
name: _C7orf24_1_m
is encoded by: hsa:C7orf24
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

metaM uppg3 c
type: Species
is: SBO:0000247
is: CHEBI:57308
has only substance units: false
boundary condition: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00643 EHMN_ABBREVIATION: C01051
constant: false
name: Uroporphyrinogen III
initial amount: NaN
is: HMDB01086
is: C01051
initial concentration: 1.0

metaR UDPGLCter
product: MODEL1310110008#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
name: UDP-Glc endoplasmic reticulum transport via CMP antiport

metaR DOLPMT3 Uer
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110008#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110008#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.260
fast: false
modifier: MODEL1310110008#
product: MODEL1310110008#

metaR AICARte
reactant: MODEL1310110008#
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110008#
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
product: MODEL1310110008#
fast: false
reversible: true

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaR HCO3 CLt
is: SBO:0000185
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
name: bicarbonate transport (Cl-/HCO3- exchange)
product: MODEL1310110008#
is described by: ECO:0000269
type: Reaction
reversible: true
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM

metaR HEX7
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000304
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
name: hexokinase (D-fructose:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.2
is version of: http://identifiers.org/ec-code/2.7.1.1
modifier: MODEL1310110008#
reversible: false
product: MODEL1310110008#
fast: false

metaM dectricoa x
is: SBO:0000247
name: 2,4,7-decatrienoylcoa
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false

metaR C16OHc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecanoylcarnitinec
type: Reaction

metaR ACHtn
product: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
is described by: ECO:0000000
kinetic law: MODEL1310110008#
fast: false
type: Reaction
name: Acetylcholin transport, nuclear trhough pores
is: SBO:0000185
reactant: MODEL1310110008#

metaM CE5867 e
name: N-acetyl-seryl-aspartyl-lysyl-proline
boundary condition: false
initial amount: NaN
constant: false
is: HMDB02710
type: Species
is: CHEBI:27485
notes: FORMULA: C20H32N5O9 CHARGE: -1 INCHI: InChI=1/C20H33N5O9/c1-11(27)22-14(10-26)18(31)24-13(9-16(28)29)17(30)23-12(5-2-3-7-21)19(32)25-8-4-6-15(25)20(33)34/h12-15,26H,2-10,21H2,1H3,(H,22,27)(H,23,30)(H,24,31)(H,28,29)(H,33,34)/p-1/t12-,13+,14-,15-/m0/s1 EHMN_ABBREVIATION: CE5867
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR TPI
modifier: MODEL1310110008#
product: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/5.3.1.1
reversible: true
type: Reaction
name: triose-phosphate isomerase
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000134

metaR DNDPt26m
modifier: MODEL1310110008#
fast: false
reversible: false
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000269
is: SBO:0000185
name: dCDP transport via dUDP antiport
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction

metaM ivcrn c
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB00688
name: isovaleryl carnitine
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C12H23NO4 CHARGE: 0
has only substance units: false

metaM leugly c
initial amount: NaN
name: Leucylglycine
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C8H16N2O3 CHARGE: 0
constant: false
is: http://identifiers.org/pubchem.compound/97364
has only substance units: false

metaM lneldc c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB06270
constant: false
name: linoelaidic acid (all trans C18:2)
boundary condition: false
type: Species
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
initial amount: NaN

metaR CHOLK
fast: false
reactant: MODEL1310110008#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.32
product: MODEL1310110008#
is: SBO:0000176
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
name: Choline kinase
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110008#_81f431a5_4cde_49f6_81d2_691deafe330d
is: Q6P4B4
is encoded by: hsa:5198
constant: false
initial concentration: NaN
has only substance units: false
name: PFAS
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_1a8651cb_5685_45e4_b732_c227ad1840fe
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3098
constant: false
type: Species
is: P78542
name: HK1
initial amount: NaN
has only substance units: false

metaR r1798
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110008#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110008#
fast: false
modifier: MODEL1310110008#
is: SBO:0000185
reactant: MODEL1310110008#

metaR FERO
type: Reaction
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
modifier: MODEL1310110008#
reversible: false
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
name: ferroxidase
kinetic law: MODEL1310110008#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_8e40617b_3635_4fcc_bf66_db5ff7030274
is encoded by: hsa:79623
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q96FL9
type: Species
name: GALNT14
initial amount: NaN

metaM aacoa c
has only substance units: false
is: C00332
initial amount: NaN
constant: false
is: HMDB01484
type: Species
name: Acetoacetyl-CoA
boundary condition: false
is: SBO:0000247
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
initial concentration: 1.0
is: CHEBI:57286

metaM mercplaccys c
is: HMDB06512
type: Species
constant: false
name: 3-mercaptolactate-cysteine disulfide
has only substance units: false
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaM ha deg1 l
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
name: hyaluronan degradation product 1
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16336
notes: FORMULA: C22H33N2O16 CHARGE: -1

metaM pmtcoa m
initial amount: NaN
is: HMDB01338
has only substance units: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
constant: false
is: C00154
type: Species
boundary condition: false
is: CHEBI:57379
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_f0077ca0_334b_46bd_9d20_bee6575d5673
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: SLC4A2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6522
initial concentration: NaN
is: F8W682

http://identifiers.org/biomodels.db/MODEL1310110008#_ede1cbdd_e1bf_4583_a845_4677088b6d3c
constant: false
type: Species
name: CA4
is encoded by: hsa:762
has only substance units: false
is: Q6FHI7
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_db943f1b_1261_400a_89c7_37520faa1c48
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:5152
name: PDE9A

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_1e4337fd_1260_466a_844e_5d31ea56bf9d
has only substance units: false
name: AKR1A1
boundary condition: true
is encoded by: hsa:10327
is: P14550
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false

metaR AIRCr
kinetic law: MODEL1310110008#
name: phosphoribosylaminoimidazole carboxylase
reversible: true
product: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/6.3.2.6

http://identifiers.org/biomodels.db/MODEL1310110008#_653a2ebc_d119_4961_99b4_5bfbe9950d30
has only substance units: false
constant: false
initial concentration: NaN
type: Species
boundary condition: true
name: ALDH3A1
is: SBO:0000252
is encoded by: hsa:218
initial amount: NaN
is: P30838

metaM i e
is: HMDB12238
initial concentration: 1.0
constant: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:16382
boundary condition: false
name: iodide
type: Species

metaR RE0691C
kinetic law: MODEL1310110008#
is: SBO:0000176
reactant: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
type: Reaction
fast: false
product: MODEL1310110008#
name: RE0691
is described by: ECO:0000000

metaM tag hs c
type: Species
has only substance units: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
is: CHEBI:17855
initial amount: NaN
initial concentration: 1.0
name: triglyceride
is: SBO:0000247
boundary condition: false
constant: false

metaR r1644
reactant: MODEL1310110008#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
modifier: MODEL1310110008#
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110008#
is: SBO:0000185

metaM hspg e
initial concentration: 1.0
name: heparan sulfate proteoglycan
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB02259
is: CHEBI:32366
type: Species

metaM elaid e
boundary condition: false
initial concentration: 1.0
name: elaidate
constant: false
is: HMDB00573
type: Species
is: CHEBI:30825
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_9de92ae5_bcb2_4c9f_a913_64c901d918eb
has only substance units: false
initial concentration: NaN
is encoded by: hsa:92483
is: Q9BYZ2
boundary condition: true
name: LDHAL6B
initial amount: NaN
type: Species
constant: false
is: SBO:0000252

metaR CYTK5
reactant: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110008#
name: cytidylate kinase (dCMP)
reversible: true
product: MODEL1310110008#
kinetic law: MODEL1310110008#

metaR HEX1
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: hexokinase (D-glucose:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.1
is version of: http://identifiers.org/ec-code/2.7.1.2
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_c174bfba_678b_4bf4_a0d2_baff121d1301
type: Species
is: SBO:0000252
is encoded by: hsa:10935
is: P30048
constant: false
initial concentration: NaN
has only substance units: false
name: PRDX3
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_5d32f0e6_3ca1_4c7d_a05f_605a2e2a14aa
initial concentration: NaN
initial amount: NaN
constant: false
is: P53396
has only substance units: false
boundary condition: true
is: SBO:0000252
name: ACLY
is encoded by: hsa:47
type: Species

metaR r2089
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110008#
reversible: true
product: MODEL1310110008#
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_4f1c45c8_f9de_4ebc_ad5a_5e24373abed5
initial amount: NaN
constant: false
initial concentration: NaN
name: _286297_1_c
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:286297

http://identifiers.org/biomodels.db/MODEL1310110008#_8a4946de_be09_4177_9276_6f2f440d0105
is encoded by: hsa:8527
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
name: DGKD
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_49e6f240_c1ef_4e25_9650_b6e00f164958
name: _AA629629_1_m
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:AA629629

metaM HC01406 m
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
constant: false
has only substance units: false
is: CHEBI:28264
name: 3-Oxooctanoyl-CoA

metaM 3octdece1coa m
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/5280355
has only substance units: false
constant: false
boundary condition: false
name: 3-hydroxyoctadecenoylcoa
initial concentration: 1.0

metaR APRGSTRNte
kinetic law: MODEL1310110008#
type: Reaction
name: hydroxyprogesterone transport
is described by: ECO:0000000
product: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
reactant: MODEL1310110008#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110008#_faf2b9da_274c_4e0f_bc60_e59e86608344
type: Species
is: P07864
name: LDHC
initial amount: NaN
is encoded by: hsa:3948
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false

metaR FAOXC163C164Gm
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

metaR r1643
reactant: MODEL1310110008#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
product: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaR CYTK6
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is described by: ECO:0000269
name: cytidylate kinase (CMP,CTP)
type: Reaction
fast: false
modifier: MODEL1310110008#
reversible: true
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110008#

metaR PPItx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110008#
reversible: true
fast: false
kinetic law: MODEL1310110008#
name: Diphosphate transporter, peroxisome
reactant: MODEL1310110008#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaM aacoa m
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: HMDB01484
is: SBO:0000247
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
name: acetoacetyl-CoA(4-)
boundary condition: false
is: CHEBI:57286
initial amount: NaN

metaR S6T2g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110008#
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_1fdc9072_02e0_47be_b5cd_5fe1273c644f
boundary condition: true
name: GALK2
constant: false
initial concentration: NaN
is encoded by: hsa:2585
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

metaR RE3004M
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE3004
product: MODEL1310110008#
is: SBO:0000176
modifier: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR ATP2ter
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110008#
name: AMP/ATP transporter, endoplasmic reticulum
product: MODEL1310110008#
type: Reaction

metaR KAS8
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
name: b-ketoacyl synthetase (palmitate, n-C16:0)
is: SBO:0000176
reactant: MODEL1310110008#
fast: false
modifier: MODEL1310110008#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110008#
type: Reaction
product: MODEL1310110008#

metaR r0698
is version of: http://identifiers.org/ec-code/3.1.2.27
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
fast: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
is: SBO:0000176
type: Reaction
modifier: MODEL1310110008#
reversible: true
kinetic law: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_f03d3e33_1d0c_4f8f_aaaa_909451524d42
is: Q04760
boundary condition: true
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2739
initial amount: NaN
name: GLO1

http://identifiers.org/biomodels.db/MODEL1310110008#_daf03f54_c677_4374_a3d8_f8801837bd2b
initial amount: NaN
is encoded by: hsa:145226
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
name: RDH12
is: Q96NR8

http://identifiers.org/biomodels.db/MODEL1310110008#_cbaf8a5d_31fc_4bfd_81f8_f5d2b6a33ca9
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:6611
type: Species
is: P52788
initial concentration: NaN
is: SBO:0000252
name: SMS
boundary condition: true

metaR CYTK7
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110008#
is described by: ECO:0000269
kinetic law: MODEL1310110008#
fast: false
modifier: MODEL1310110008#
product: MODEL1310110008#
name: cytidylate kinase (CMP,UTP)
is: SBO:0000176
type: Reaction

metaR r1642
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
modifier: MODEL1310110008#
reversible: true
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110008#

metaM tag hs e
initial amount: NaN
is: CHEBI:17855
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
is: SBO:0000247
name: triglyceride
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_b3a53472_e6e5_4f80_9856_ec816628ba34
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:83594
name: NUDT12
type: Species
is: Q9BQG2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_961b70f0_c2a1_4f2d_932c_d32c2b4efe6e
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:80025
initial amount: NaN
name: PANK2
constant: false
is: Q6P1K9
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_18a48291_5352_4aee_af61_224434aa0496
is: SBO:0000252
is encoded by: hsa:53
is: E9PCI1
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
name: ACP2
has only substance units: false
boundary condition: true

metaM elaid c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
name: elaidate
type: Species
is: HMDB00573
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:30825
constant: false

metaR DINt
name: deoxyinosine transport via diffusion
type: Reaction
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
fast: false
reactant: MODEL1310110008#
product: MODEL1310110008#
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaR r2087
reactant: MODEL1310110008#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
product: MODEL1310110008#
fast: false
modifier: MODEL1310110008#
reversible: true
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_8669b91d_ec5d_4c40_8293_4c00b8f89831
name: MCCC1:MCCC2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:64087
type: Species
has part: Q9HCC0
is: SBO:0000297
initial amount: NaN
has part: Q96RQ3
is encoded by: hsa:56922
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_ac285238_075a_4949_b617_83a891b4f320
initial amount: NaN
is encoded by: hsa:10317
initial concentration: NaN
constant: false
type: Species
name: B3GALT5
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR DNDPt15m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
kinetic law: MODEL1310110008#
is: SBO:0000185
reactant: MODEL1310110008#
type: Reaction
name: dUDP transport via dGDP antiport
is described by: ECO:0000269
reversible: false
product: MODEL1310110008#
modifier: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_0b9f8b17_8283_47fd_8e43_ab365d320441
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ZADH2
is encoded by: hsa:284273
is: Q8N4Q0
boundary condition: true
constant: false
initial concentration: NaN
type: Species

metaM o2s c
initial amount: NaN
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: CHEBI:18421
is: HMDB02168
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: superoxide

http://identifiers.org/biomodels.db/MODEL1310110008#_4cc55a13_ad61_41e4_a069_e2a4185f3570
is: P60891
initial concentration: NaN
name: PRPS1
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:5631
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_32496477_9833_46e8_ac90_97523c817f01
name: PDE9A
is encoded by: hsa:5152
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species

metaM tetpent6 c
is: SBO:0000247
name: tetracosapentaenoic acid, n-6
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB06322
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
has only substance units: false
type: Species

metaM ksi l
has only substance units: false
is: C00445
is: CHEBI:57455
initial concentration: 1.0
name: keratan sulfate I
is: HMDB01354
boundary condition: false
is: SBO:0000247
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
initial amount: NaN
type: Species
constant: false

metaM ru5p D c
boundary condition: false
name: D-ribulose 5-phosphate(2-)
is: CHEBI:58121
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00618
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188

metaR EX CE5867 LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acetyl-seryl-aspartyl-lysyl-proline exchange
type: Reaction

metaR CYTK8
product: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,dATP)
fast: false
reactant: MODEL1310110008#
modifier: MODEL1310110008#
reversible: true
kinetic law: MODEL1310110008#

metaR S6TASE1ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110008#
type: Reaction
fast: false
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true

metaR r1641
modifier: MODEL1310110008#
reversible: true
fast: false
product: MODEL1310110008#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#

metaR r2088
type: Reaction
is described by: ECO:0000000
product: MODEL1310110008#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
modifier: MODEL1310110008#

metaM ha pre1 e
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
boundary condition: false
constant: false
initial concentration: 1.0
name: hyaluronan biosynthesis, precursor 1
type: Species
is: CHEBI:16126
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR UAGDP
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
reactant: MODEL1310110008#
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
name: UDP-N-acetylglucosamine diphosphorylase
modifier: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.23
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_3ec1c443_9e64_4692_b346_eb92e90ddcab
constant: false
boundary condition: true
initial amount: NaN
is: P23434
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:2653
name: GCSH

http://identifiers.org/biomodels.db/MODEL1310110008#_1bc4cf8a_6a5d_4ec6_abd9_6e3590109645
is: C9JFZ1
constant: false
initial concentration: NaN
name: SYNJ1
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:8867
boundary condition: true

metaR PPItr
kinetic law: MODEL1310110008#
name: Diphosphate transporter, endoplasmic reticulum
reactant: MODEL1310110008#
is: SBO:0000185
product: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
type: Reaction
fast: false

metaM cdpea c
has only substance units: false
notes: FORMULA: C11H19N4O11P2 CHARGE: -1 INCHI: InChI=1S/C11H20N4O11P2/c12-2-4-23-27(19,20)26-28(21,22)24-5-6-8(16)9(17)10(25-6)15-3-1-7(13)14-11(15)18/h1,3,6,8-10,16-17H,2,4-5,12H2,(H,19,20)(H,21,22)(H2,13,14,18)/p-1/t6-,8-,9-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00433 EHMN_ABBREVIATION: C00570
is: CHEBI:57876
name: cdpea[c]
type: Species
boundary condition: false
initial amount: NaN
is: HMDB01564
is: SBO:0000247
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_311f3de2_a245_40b1_bcfb_35a6953a98dc
is: SBO:0000252
is encoded by: hsa:1629
type: Species
name: DBT
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is: P11182
initial concentration: NaN

metaR r2084
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110008#
is: SBO:0000185
modifier: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
fast: false

metaR r2085
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110008#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
modifier: MODEL1310110008#
reversible: true

metaR CYTK1
is described by: ECO:0000269
kinetic law: MODEL1310110008#
is: SBO:0000176
type: Reaction
product: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
name: cytidylate kinase (CMP)

metaR r1640
fast: false
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110008#
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_85c2d09b_b1ee_4bf7_87e7_6f883b04cc46
is: P46459
name: NSF
is encoded by: hsa:4905
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN

metaR DOLMANP Lter
fast: false
is: SBO:0000185
reversible: false
name: dolichol-phosphate mannose flippase (liver)
product: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110008#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110008#_e34a9d80_d31c_44a8_bec7_9569959b117e
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AL525798
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
name: _AL525798_1_c

metaM ipdp x
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB01347
type: Species
is: CHEBI:128769
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
name: isopentenyl diphosphate(3-)
has only substance units: false
initial amount: NaN
constant: false

metaM homoval m
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
type: Species
is: CHEBI:545959
name: Homovanillate
initial concentration: 1.0
is: HMDB00118
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
boundary condition: false

metaM ttetddcoa m
initial amount: NaN
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
name: trans5,8tetradecadienoylcoa
is: HMDB02288
initial concentration: 1.0

metaM Ssq23epx r
initial amount: NaN
boundary condition: false
is: CHEBI:15441
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
type: Species
constant: false
name: (S)-2,3-epoxysqualene
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01188

http://identifiers.org/biomodels.db/MODEL1310110008#_cdd427cc_1d93_4cd5_94ae_1d21173dfe1a
initial amount: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
is: Q8N5Z0
initial concentration: NaN
is encoded by: hsa:51166
is: SBO:0000252
name: AADAT

metaR PRGNLONESULT
fast: false
product: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.14
reversible: false
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (6822.1) or (6820.2) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:12145317,PMID:9799594 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.8.2.2
type: Reaction
name: steroid sulfotransferase
is described by: ECO:0000269
modifier: MODEL1310110008#
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_b9b9a3a5_4558_42b5_9c89_c001ae49a00c
is encoded by: hsa:10317
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
name: B3GALT5

metaM pmtcoa c
has only substance units: false
name: Palmitoyl-CoA (n-C16:0CoA)
is: HMDB01338
initial concentration: 1.0
is: SBO:0000247
is: C00154
constant: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:3454

metaR r2086
is described by: ECO:0000000
product: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
type: Reaction
modifier: MODEL1310110008#

metaR FAOXC246226x
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:6 -> c22:6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
is: SBO:0000176
modifier: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
name: Beta oxidation of long chain fatty acid
kinetic law: MODEL1310110008#
reversible: false
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR RE3566C
name: RE3566
kinetic law: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110008#
product: MODEL1310110008#

metaR CYTK2
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110008#
modifier: MODEL1310110008#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110008#
name: cytidylate kinase (dCMP)
reversible: true
kinetic law: MODEL1310110008#
fast: false

metaM i c
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: HMDB12238
name: iodide
initial amount: NaN
type: Species
is: CHEBI:16382
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_a7ceecc9_c1ce_4312_afd8_72b7edee803f
has only substance units: false
is encoded by: hsa:10841
boundary condition: true
name: FTCD
initial amount: NaN
constant: false
is: O95954
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_8f9bcc3c_2f56_4069_b2d8_421bd02b8d2d
boundary condition: true
is encoded by: hsa:1806
is: Q12882
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
name: DPYD
has only substance units: false
is: SBO:0000252

metaR r2082
type: Reaction
fast: false
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110008#
modifier: MODEL1310110008#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_1bc36236_da58_4abb_a96c_f4a9023bcc07
is: P82251
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:11136
constant: false
type: Species
boundary condition: true
name: SLC7A9
has only substance units: false

metaR CYOOm3
product: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
name: cytochrome c oxidase, mitochondrial Complex IV
reversible: false
is version of: http://identifiers.org/ec-code/1.9.3.1
kinetic law: MODEL1310110008#
is described by: ECO:0000134
reactant: MODEL1310110008#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110008#

metaM ksi g
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: HMDB01644
has only substance units: false
name: keratan sulfate I
is: SBO:0000247
is: CHEBI:17140

metaR DLNLCGCRNt
fast: false
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110008#
name: transport into the mitochondria (carnitine)
type: Reaction
reversible: false

metaM 3decdicoa x
is: SBO:0000247
type: Species
initial amount: NaN
name: 3,7-decadienoylcoa
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
has only substance units: false

metaR GALASE16ly
modifier: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR r1791
reactant: MODEL1310110008#
reversible: false
fast: false
product: MODEL1310110008#
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is: SBO:0000185
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110008#_c1f9303b_5520_4261_a341_47af02e78aab
name: HADH
has only substance units: false
boundary condition: true
type: Species
constant: false
is encoded by: hsa:3033
is: Q16836
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR CYTK3
is: SBO:0000176
type: Reaction
name: cytidylate kinase (CMP)(GTP)
fast: false
is described by: ECO:0000269
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.4.3
modifier: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#

metaR SERtp
reversible: true
reactant: MODEL1310110008#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:10347152 NOTES:MM
is: SBO:0000185
name: L-serine transport, peroxisomal
kinetic law: MODEL1310110008#
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_5625dc17_38a6_4c68_9a3a_ab913e0045b2
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:275
has part: P23434
is encoded by: hsa:2731
is encoded by: hsa:2653
has part: P23378
is: SBO:0000297
boundary condition: true
has part: P48728
has only substance units: false
initial concentration: NaN
name: DLD:GCSH:GLDC:AMT

metaR r2083
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000000
modifier: MODEL1310110008#
is: SBO:0000185
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
product: MODEL1310110008#

metaR NDP7g
kinetic law: MODEL1310110008#
type: Reaction
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110008#
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.6.1.6
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
fast: false
reactant: MODEL1310110008#
is: SBO:0000176
name: nucleoside-diphosphatase (UDP), Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110008#_374f097e_1d64_41c7_b73d_a1c2708bbf4f
type: Species
name: BLVRA
has only substance units: false
constant: false
is: P53004
boundary condition: true
is: SBO:0000252
is encoded by: hsa:644
initial amount: NaN
initial concentration: NaN

metaR FAOXC61m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

metaR FAOXC10C10OHm
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->OHC10)m
type: Reaction

metaM hx2coa x
is: http://identifiers.org/pubchem.compound/11966188
is: HMDB06870
is: C05998
initial concentration: 1.0
type: Species
name: trans-Hex-2-enoyl-CoA
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4

metaR 3SPYRSPm
type: Reaction
reversible: false
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
is described by: ECO:0000000
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
fast: false
product: MODEL1310110008#
is: SBO:0000176
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_f6af5a40_c377_4844_b36c_2c11abc0d9a4
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:2194
constant: false
is: P49327
type: Species
is: SBO:0000252
name: FASN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_dc1349c1_2203_45f0_9ec5_bf5baf8883cb
boundary condition: true
constant: false
is: F5H066
name: SLC12A4
is: SBO:0000252
type: Species
is encoded by: hsa:6560
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_33c11099_d945_4093_8edf_dd262c294840
is encoded by: hsa:AF116616
initial amount: NaN
name: _AF116616_1_m
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true

metaR CYTK4
reactant: MODEL1310110008#
is: SBO:0000176
kinetic law: MODEL1310110008#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.3
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
product: MODEL1310110008#
name: cytidylate kinase (dCMP)(GTP)
reversible: true
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110008#_464f73c8_11a7_4e55_8c52_b6081e185ecd
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
name: GAPDH
is encoded by: hsa:2597
constant: false
is: E7EUT4

metaM glu L e
constant: false
is: SBO:0000247
is: CHEBI:29985
name: L-glutamate(1-)
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: HMDB00148
initial amount: NaN
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025

http://identifiers.org/biomodels.db/MODEL1310110008#_c573625a_f99f_48c3_939d_d5974e62e660
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
has part: P48201
is: SBO:0000297
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:518
constant: false

metaR r1856
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110008#
is: SBO:0000185
type: Reaction
name: Y+LAT2 Utilized transport
product: MODEL1310110008#
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000000
fast: false

metaM hspg l
name: heparan sulfate proteoglycan
type: Species
initial amount: NaN
is: HMDB01993
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
is: CHEBI:17899
is: SBO:0000247
initial concentration: 1.0

metaR FACOAL184
is described by: ECO:0000000
fast: false
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
reversible: true
type: Reaction
name: fatty-acid--CoA ligase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110008#_7ef99769_3605_43e6_9b04_8b4eb3181ed0
initial concentration: NaN
is: P14324
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
name: FDPS
initial amount: NaN
constant: false
is encoded by: hsa:2224

metaR GDPtg
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
fast: false
is: SBO:0000185
kinetic law: MODEL1310110008#
name: GDP intracellular transport
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110008#

metaM pmtcoa x
initial amount: NaN
is: HMDB01338
name: Palmitoyl-CoA (n-C16:0CoA)
is: C00154
has only substance units: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
constant: false
is: CHEBI:57379
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_4e28ed9e_5e4e_4f7e_bef1_0807243c88f4
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:W87865
initial amount: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
name: _W87865_1_c

http://identifiers.org/biomodels.db/MODEL1310110008#_8382bedc_3d98_42b3_b6ee_b5b7d2c3a06c
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: SLC24A4
type: Species
is encoded by: hsa:123041
constant: false

metaM 7dhchsterol r
constant: false
is: HMDB00032
is: CHEBI:17759
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
is: SBO:0000247
boundary condition: false
name: cholesta-5,7-dien-3beta-ol
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_73ae1282_190d_4f94_b9c2_281818ab36a1
name: ACAA2
is encoded by: hsa:10449
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is: P42765
boundary condition: true
initial amount: NaN
type: Species

metaR NTD3
fast: false
modifier: MODEL1310110008#
is: SBO:0000176
reversible: false
product: MODEL1310110008#
name: 5'-nucleotidase (dCMP)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.5
notes: GENE_ASSOCIATION: (93034.1) or (30833.1) or (93034.2) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
kinetic law: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_6ab44941_5402_4cf7_b399_335a333a9251
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:270
initial concentration: NaN
has only substance units: false
name: AMPD1
initial amount: NaN
is: P23109
boundary condition: true

metaR DNDPt37m
modifier: MODEL1310110008#
type: Reaction
name: dUTP transport via dTDP antiport
product: MODEL1310110008#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000269

metaR r2081
reactant: MODEL1310110008#
modifier: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110008#
reversible: true
type: Reaction

metaR L LACt4r
kinetic law: MODEL1310110008#
reversible: true
is: SBO:0000185
product: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
name: L-lactate reversible transport via sodium symport
type: Reaction
fast: false
reactant: MODEL1310110008#

metaR HOXG
is described by: ECO:0000134
is: SBO:0000176
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.14.99.3
type: Reaction
name: Heme oxygenase 1
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#

metaR CO2tm
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
fast: false
reversible: true
product: MODEL1310110008#
is: SBO:0000185
type: Reaction
name: CO2 transport (diffusion), mitochondrial
is described by: ECO:0000000
kinetic law: MODEL1310110008#

metaR SUBERCROT
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberyl carnitine
type: Reaction

metaR PYNP2r
is version of: http://identifiers.org/ec-code/2.4.2.3
kinetic law: MODEL1310110008#
reversible: true
reactant: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction
fast: false
is described by: ECO:0000269
name: pyrimidine-nucleoside phosphorylase (uracil)
is: SBO:0000176
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2

metaR ALDD2x
is: SBO:0000176
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
name: aldehyde dehydrogenase (acetaldehyde, NAD)
reversible: false
product: MODEL1310110008#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.2.1.36

metaR PHYCBOXL
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000176
reactant: MODEL1310110008#
type: Reaction
modifier: MODEL1310110008#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.28
name: L-Phenylalanine carboxy-lyase
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110008#_0fb92468_a4a3_46d4_8e70_4dcf39fba0d7
boundary condition: true
is: SBO:0000252
name: _LOC728997_1_c
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:LOC728997

metaM dhlam m
is: CHEBI:17694
name: dihydrolipoamide
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00985
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false

metaM digalside hs l
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
is: C06126
initial amount: NaN
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/8383
boundary condition: false
has only substance units: false
name: Digalactosylceramide
is: SBO:0000247
constant: false

metaM o2s x
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:18421
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial amount: NaN
name: superoxide
has only substance units: false
is: SBO:0000247
is: HMDB02168
boundary condition: false

metaR PSDm hs
product: MODEL1310110008#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
is: SBO:0000176
kinetic law: MODEL1310110008#
name: Phosphatidylserine decarboxylase
type: Reaction
fast: false
modifier: MODEL1310110008#
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/4.1.1.65
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110008#_b85ee9d4_57dd_4a60_ab42_9476eb9c3f51
type: Species
initial concentration: NaN
name: COQ2
boundary condition: true
has only substance units: false
is: Q96H96
constant: false
is: SBO:0000252
is encoded by: hsa:27235
initial amount: NaN

metaR NTD1
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110008#
name: 5'-nucleotidase (dUMP)
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
is: SBO:0000176
is described by: ECO:0000269
reversible: false
type: Reaction

metaR r2080
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110008#
reactant: MODEL1310110008#
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110008#_cdde4618_565d_4c59_b032_d0fddc2c2185
has part: Q9UBK5
is encoded by: hsa:10870
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000297
name: HCST:PIK3CG
has part: P48736
boundary condition: true
is encoded by: hsa:5294

metaR ALDD2y
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
product: MODEL1310110008#
is described by: ECO:0000000
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.2.1.36
name: aldehyde dehydrogenase (acetaldehyde, NADP)
is: SBO:0000176
reversible: false
reactant: MODEL1310110008#
fast: false
modifier: MODEL1310110008#

metaR C4DCCACT
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinyl carnitine into cytosol
type: Reaction

metaR r0149
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000176
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/1.14.13.39
fast: false
reversible: true
type: Reaction
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110008#

metaM adrncoa c
has only substance units: false
boundary condition: false
name: adrenyl coenzyme A
is: C16170
initial concentration: 1.0
constant: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205480
initial amount: NaN
is: SBO:0000247
type: Species

metaR r1649
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110008#

metaM dectricoa m
constant: false
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: 2,4,7-decatrienoylcoa
is: SBO:0000247
type: Species
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_3c3b6f62_177a_4bc6_b404_91ed87469e70
boundary condition: true
initial amount: NaN
is encoded by: hsa:6547
initial concentration: NaN
constant: false
name: SLC8A3
has only substance units: false
type: Species
is: SBO:0000252

metaR TTDCAFATPc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaR FAOXC165C164m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

metaM xol7ah3 c
initial amount: NaN
is: CHEBI:28540
boundary condition: false
initial concentration: 1.0
name: 5beta-cholestane-3alpha,7alpha,26-triol
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
has only substance units: false
type: Species
constant: false
is: HMDB12455
is: SBO:0000247

metaM dec24dicoa m
boundary condition: false
type: Species
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: 2,4-decadienoylcoa
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB01168
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_9e48728b_e8f9_46c6_8404_f4490b458f13
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: E9KL48
name: GLUD1
is encoded by: hsa:2746
initial concentration: NaN
is: SBO:0000252
type: Species

metaR CERT2rt
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
name: ceramide transport protein
modifier: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_033df657_9223_4e25_91c3_7bf09e5ee914
type: Species
boundary condition: true
initial concentration: NaN
name: FUT8
has only substance units: false
is: Q546E0
initial amount: NaN
is encoded by: hsa:2530
constant: false
is: SBO:0000252

metaM ksii core4 deg2 l
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
constant: false
is: HMDB00143
initial concentration: 1.0
is: CHEBI:12936
name: keratan sulfate II (core 4-linked), degradation product 2

metaR MALSO3tm
is described by: ECO:0000269
fast: false
reactant: MODEL1310110008#
name: Malate:sulfite antiport, mitochondrial
kinetic law: MODEL1310110008#
is: SBO:0000185
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reversible: true
type: Reaction
product: MODEL1310110008#

metaR RE1573M
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110008#
modifier: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
name: RE1573
reversible: true
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.3.8

metaM r5p c
initial amount: NaN
is: C00117
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
boundary condition: false
type: Species
initial concentration: 1.0
name: alpha-D-Ribose 5-phosphate
is: CHEBI:18189
constant: false
is: HMDB00618
has only substance units: false

metaR G3PD1
kinetic law: MODEL1310110008#
is: SBO:0000176
type: Reaction
reversible: true
name: glycerol-3-phosphate dehydrogenase (NAD)
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.8
modifier: MODEL1310110008#
reactant: MODEL1310110008#

metaM pe hs m
initial concentration: 1.0
name: phosphatidylethanolamine
type: Species
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:16038
initial amount: NaN
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350

http://identifiers.org/biomodels.db/MODEL1310110008#_ac8ab604_1208_4fb2_a892_312398c98f1c
type: Species
is: O95864
initial amount: NaN
has only substance units: false
name: FADS2
is encoded by: hsa:9415
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_b4f4f653_7398_4a77_87c9_c51e24dd9302
has only substance units: false
is: O15357
name: INPPL1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3636
type: Species
boundary condition: true
constant: false
initial amount: NaN

metaM ksi pre3 g
has only substance units: false
is: C00130
constant: false
type: Species
notes: FORMULA: C93H152N6O67X CHARGE: -1
is: SBO:0000247
is: CHEBI:58053
initial amount: NaN
is: HMDB00175
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 3
boundary condition: false

metaR CO2tp
reactant: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
name: CO2 peroxisomal transport
fast: false
reversible: true

metaR NTD7
reversible: false
name: 5'-nucleotidase (AMP)
is: SBO:0000176
reactant: MODEL1310110008#
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.5
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
product: MODEL1310110008#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_f81f2b2e_2f96_45df_a918_5f057983aaa7
is encoded by: hsa:6487
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
name: ST3GAL3

http://identifiers.org/biomodels.db/MODEL1310110008#_bda2b0bc_92d4_47be_a748_74038259bd33
has only substance units: false
initial amount: NaN
boundary condition: true
is: O75106
name: AOC2
is encoded by: hsa:314
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species

metaM 3ttetddcoacrn e
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
is: HMDB02014
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C21H37NO5 CHARGE: 0
constant: false
type: Species
initial amount: NaN
boundary condition: false

metaM udpacgal l
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: HMDB00304
initial amount: NaN
name: UDP-N-acetyl-D-galactosamine(2-)
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57847
boundary condition: false
type: Species
constant: false
has only substance units: false

metaR FAOXC61x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)x
type: Reaction

metaM dttp c
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: C00459
constant: false
has only substance units: false
is: CHEBI:37568
name: dTTP
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: HMDB01342
is: SBO:0000247

metaR r1647
modifier: MODEL1310110008#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
product: MODEL1310110008#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110008#
reversible: true
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM HC00342 c
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
constant: false
is: SBO:0000247
is: CHEBI:16383
type: Species
name: cis-aconitate(3-)

metaR AG13T7g
modifier: MODEL1310110008#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110008#
reversible: false
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
fast: false

metaR PROSTGE1t
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
fast: false
reactant: MODEL1310110008#
modifier: MODEL1310110008#
is: SBO:0000185
name: prostaglandin transport via bicarbonate countertransport
kinetic law: MODEL1310110008#
is described by: ECO:0000269
reversible: true
product: MODEL1310110008#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_2216ee9a_dcd0_44b9_828c_3d20aeec2f78
is encoded by: hsa:93034
name: NT5C1B
type: Species
is: SBO:0000252
is: B3KUK6
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_564de346_1e8a_4a52_9286_113f436bab63
is: P38571
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
name: LIPA
is encoded by: hsa:3988
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_17c3fe97_be72_4b1f_aedb_7144b61cf846
initial concentration: NaN
is encoded by: hsa:10846
initial amount: NaN
type: Species
name: PDE10A
has only substance units: false
boundary condition: true
constant: false
is: Q9Y233
is: SBO:0000252

metaR NTD6
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is: SBO:0000176
is described by: ECO:0000134
name: 5'-nucleotidase (dAMP)
product: MODEL1310110008#
fast: false
reversible: false
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110008#
type: Reaction

metaR GLYt2r
type: Reaction
name: glycine reversible transport via proton symport
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
reversible: true
is described by: ECO:0000304
is: SBO:0000185
product: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD

metaR r1648
fast: false
kinetic law: MODEL1310110008#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110008#
reversible: true

metaM 3deccrn e
initial concentration: 1.0
type: Species
is: HMDB02250
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C17H33NO5 CHARGE: 0
has only substance units: false
boundary condition: false
name: 3-hydroxydecanoylcarnitine

metaR r1851
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110008#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_067709c4_ff4c_452a_bd62_05f978a11991
type: Species
constant: false
initial amount: NaN
name: EGFL8
is encoded by: hsa:80864
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q99944
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_fe004c2a_c5e2_400e_a870_7255cdce352c
has only substance units: false
initial concentration: NaN
is: Q6IRT1
type: Species
name: ADH5
is encoded by: hsa:128
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_a5a85902_80f5_4a03_88f9_9ea78050235a
is: SBO:0000252
type: Species
initial amount: NaN
name: SLC23A1
has only substance units: false
is encoded by: hsa:9963
initial concentration: NaN
boundary condition: true
constant: false

metaM 3ttetddcoacrn c
constant: false
notes: FORMULA: C21H37NO5 CHARGE: 0
is: HMDB02014
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
type: Species

metaR DECDPtm
reversible: true
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:ubiquinone precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
name: lipid, flip-flop intracellular transport
type: Reaction
is: SBO:0000185
reactant: MODEL1310110008#
fast: false

metaR NACHEX25ly
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
modifier: MODEL1310110008#
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110008#
is described by: ECO:0000000

metaM glu L m
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: L-glutamate(1-)
type: Species
is: HMDB00148
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: CHEBI:29985

metaR r0580
reactant: MODEL1310110008#
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.7
is: SBO:0000176
kinetic law: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110008#
fast: false

metaR NTD5
type: Reaction
reactant: MODEL1310110008#
is described by: ECO:0000134
name: 5'-nucleotidase (dTMP)
fast: false
reversible: false
modifier: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:4291247 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Not clear whether it is cytosolic but enzymes in this metabolism often are
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.3.5

metaR r0475
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110008#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reversible: true

metaR SUBERICACT
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of suberic acid for formation of suberyl carnitine
type: Reaction

metaR r1645
reversible: true
reactant: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false

metaM dttp e
initial amount: NaN
type: Species
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:37568
name: dTTP(4-)
is: HMDB01342
has only substance units: false
is: SBO:0000247

metaR GALASE20ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110008#
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110008#

metaR EX pydx LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Pyridoxal
type: Reaction

metaR G14T18g
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is: SBO:0000176
fast: false
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38

metaM ctp n
is: HMDB00082
boundary condition: false
is: CHEBI:37563
is: SBO:0000247
name: CTP(4-)
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
type: Species

metaM ksi deg11 l
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
initial concentration: 1.0
initial amount: NaN
is: HMDB00143
has only substance units: false
boundary condition: false
name: keratan sulfate I, degradation product 11
type: Species
is: SBO:0000247
constant: false
is: CHEBI:12936

metaR 5ADTSTSTERONEte
type: Reaction
reactant: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110008#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
name: 5 alpha dihydrotesterone transport
product: MODEL1310110008#

metaM 3deccrn c
constant: false
is: HMDB00651
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C17H33NO5 CHARGE: 0
has only substance units: false
name: 3-hydroxydecanoylcarnitine
initial concentration: 1.0

metaM 5aop c
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
initial amount: NaN
is: CHEBI:17549
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB01149
is: SBO:0000247
name: 5-Amino-4-oxopentanoate
constant: false
is: C00430
type: Species

metaR r1646
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: true

metaM acgam1p c
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: HMDB01367
name: N-Acetyl-D-glucosamine 1-phosphate
is: CHEBI:7125
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256

http://identifiers.org/biomodels.db/MODEL1310110008#_e3fe4755_632a_4b29_9f22_e403cbd8e3bf
boundary condition: true
initial amount: NaN
type: Species
name: CYP19A1
constant: false
is encoded by: hsa:1588
has only substance units: false
initial concentration: NaN
is: Q8TCA4
is: SBO:0000252

metaR ACGAMK
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
kinetic law: MODEL1310110008#
is: SBO:0000176
name: N-acetylglucosamine kinase
modifier: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.1.59
is described by: ECO:0000269
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_f2d6ba40_544c_4597_be2a_155fb1c69acf
boundary condition: true
constant: false
name: GSTZ1
initial amount: NaN
type: Species
has only substance units: false
is: O43708
initial concentration: NaN
is encoded by: hsa:2954
is: SBO:0000252

metaR SERPT
kinetic law: MODEL1310110008#
product: MODEL1310110008#
name: serine C-palmitoyltransferase
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
modifier: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.50
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110008#_99c4803c_0712_4220_885d_ce286d636e2e
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: Q9NX14
is encoded by: hsa:54539
is: SBO:0000252
name: NDUFB11

metaR RETI2
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
product: MODEL1310110008#
name: retinol isomerase (9-cis)
reactant: MODEL1310110008#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_4364e916_c655_4bf8_a944_3ea527125448
is: SBO:0000252
is: P11182
constant: false
boundary condition: true
name: DBT
initial amount: NaN
is encoded by: hsa:1629
has only substance units: false
type: Species
initial concentration: NaN

metaR NDPK6m
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
product: MODEL1310110008#
is described by: ECO:0000254
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.

http://identifiers.org/biomodels.db/MODEL1310110008#_8c8be911_870b_434d_b41c_fa3ebade5317
is encoded by: hsa:4708
name: NDUFB2
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: H7C5B8
has only substance units: false
is: SBO:0000252
type: Species

metaM ipdp c
is: C00129
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:128769
has only substance units: false
is: HMDB01347
name: Isopentenyl diphosphate
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129

http://identifiers.org/biomodels.db/MODEL1310110008#_c8ac939e_978a_4dbf_8a9f_22c75640df46
name: GSTZ1
has only substance units: false
is encoded by: hsa:2954
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_7f90273e_aaa3_487a_9565_605a038d4c47
is: SBO:0000252
is encoded by: hsa:8897
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
name: MTMR3

metaR ACALDt
is: SBO:0000185
name: acetaldehyde reversible transport
fast: false
is described by: ECO:0000000
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110008#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_7d46612c_679c_4e6a_8f32_ff4a31102fdf
type: Species
is: SBO:0000252
is: P05496
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:516
name: ATP5G1
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_48d90abf_ea8d_414a_8088_17940ddb09a0
name: AOC3
is: Q16853
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:8639
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN

metaM tetdece1crn c
constant: false
is: SBO:0000247
is: HMDB02014
has only substance units: false
name: tetradecenoyl carnitine
type: Species
notes: FORMULA: C21H39NO4 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM leugly e
notes: FORMULA: C8H16N2O3 CHARGE: 0
constant: false
name: Leucylglycine
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/97364
type: Species
is: SBO:0000247

metaM ru5p D r
constant: false
is: CHEBI:58121
initial amount: NaN
boundary condition: false
name: D-ribulose 5-phosphate(2-)
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: HMDB00618
type: Species

metaR 5MTAte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 5-S-methyl-5-thioadenosine
reversible: true
product: MODEL1310110008#
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000134

metaM digalside hs c
constant: false
boundary condition: false
type: Species
is: SBO:0000247
name: Digalactosylceramide
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/8383
is: C06126
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126

metaM ctp m
is: SBO:0000247
boundary condition: false
type: Species
name: CTP(4-)
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
constant: false
is: HMDB00082
is: CHEBI:37563
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM idp e
name: IDP(3-)
is: SBO:0000247
initial concentration: 1.0
is: HMDB03335
constant: false
is: CHEBI:58280
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN

metaM 3decdicoa m
type: Species
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
name: 3,7-decadienoylcoa
initial amount: NaN

metaR DESAT22 1p
fast: false
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
type: Reaction
reactant: MODEL1310110008#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000000

metaM pe hs c
is: SBO:0000247
initial concentration: 1.0
name: phosphatidylethanolamine
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:16038
constant: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110008#_7a5a1460_b9d8_4b9c_a621_e8b8e6517339
has only substance units: false
name: SLC7A5
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:8140
boundary condition: true
is: Q8IV97

metaR RE2626C
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110008#
reactant: MODEL1310110008#
name: RE2626
is: SBO:0000176
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110008#_6fa222d9_5163_488d_8ca7_63369ffef6b2
type: Species
is: SBO:0000297
boundary condition: true
is encoded by: hsa:498
has part: B4DY56
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN

metaM HC00718 c
boundary condition: false
is: SBO:0000247
is: CHEBI:57781
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: N-methylethanolaminium phosphate(1-)
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1

http://identifiers.org/biomodels.db/MODEL1310110008#_7dfc056b_3722_4b3f_8207_302913d62d87
is encoded by: hsa:93183
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is: Q9H3S5
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: PIGM

metaR PIACGT
product: MODEL1310110008#
type: Reaction
fast: false
name: phosphatidylinositol N-acetylglucosaminyltransferase
reversible: false
reactant: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.83
is: SBO:0000176
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.1.198
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…

metaR r0587
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
is described by: ECO:0000000
fast: false
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
reversible: true
modifier: MODEL1310110008#
product: MODEL1310110008#

metaM dec24dicoa x
boundary condition: false
has only substance units: false
name: 2,4-decadienoylcoa
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: HMDB01168
initial amount: NaN

metaM n2m2nmn l
is: http://identifiers.org/pubchem.compound/3324
has only substance units: false
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
is: CHEBI:15361
notes: FORMULA: C50H84N4O36 CHARGE: 0
type: Species
is: C00022
initial concentration: 1.0
is: HMDB00243
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR r0474
reactant: MODEL1310110008#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reversible: true
product: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:

metaR r0142
is described by: ECO:0000000
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
reversible: false
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
fast: false
type: Reaction
product: MODEL1310110008#
reactant: MODEL1310110008#

metaR DOPASULT
modifier: MODEL1310110008#
is: SBO:0000176
reactant: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.8.2.1
reversible: false
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)
name: Dopamine Sulfotransferase
is described by: ECO:0000269
type: Reaction
product: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_0638b799_8a54_4076_8bb3_ceb5bf55f397
name: FLAD1
initial amount: NaN
is encoded by: hsa:80308
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true

metaM 5aop m
is: HMDB01149
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
constant: false
initial amount: NaN
is: C00430
is: CHEBI:17549
name: 5-Amino-4-oxopentanoate

metaR EX dgsn LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyguanosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_62a8ec1b_d8da_4b56_9095_d910f6ef61d5
is: SBO:0000252
type: Species
is: B3KT19
has only substance units: false
is encoded by: hsa:5295
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
name: PIK3R1

metaM so3 c
boundary condition: false
is: C00094
is: CHEBI:17137
name: Sulfite
has only substance units: false
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00240

metaM hpdcacrn m
initial concentration: 1.0
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
name: heptadecanoyl carnitine
is: HMDB06210
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
type: Species

metaR SARCStm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
name: Sarcosine transport (mitochondrial)
reactant: MODEL1310110008#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
is described by: ECO:0000000
fast: false

metaR FAOXC5C5OHm
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C5OH)m
type: Reaction

metaM pmtcoa r
initial amount: NaN
is: C00154
boundary condition: false
name: Palmitoyl-CoA (n-C16:0CoA)
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: CHEBI:3454
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: HMDB01338
is: SBO:0000247

metaR GLNS
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: glutamine synthetase
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/4.1.1.15
modifier: MODEL1310110008#
type: Reaction
fast: false
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_7f8a5de2_ba95_4e26_975e_a68e8a73b7b5
boundary condition: true
is encoded by: hsa:AA081045
name: _AA081045_1_m
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR r0584
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
reversible: true
reactant: MODEL1310110008#
modifier: MODEL1310110008#
is: SBO:0000176
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110008#_4ac7d56d_2859_4e66_854f_02327189c701
initial concentration: NaN
is: SBO:0000252
type: Species
is: A8K3L7
constant: false
boundary condition: true
name: CDIPT
initial amount: NaN
is encoded by: hsa:10423
has only substance units: false

metaM acrn c
initial amount: NaN
is: HMDB00201
is: CHEBI:57589
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
constant: false
type: Species
boundary condition: false
name: O-acetylcarnitine
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM eitetcoa x
type: Species
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
constant: false
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
name: 5,8,11,14-eicosatetraenoylcoa
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_d21416f1_ce98_4ad9_b343_ef8db9e6dfd4
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is: P00374
is encoded by: hsa:1719
name: DHFR
initial concentration: NaN
initial amount: NaN

metaM xol7ah3 m
initial concentration: 1.0
is: CHEBI:28540
boundary condition: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
is: SBO:0000247
constant: false
type: Species
name: 5beta-cholestane-3alpha,7alpha,26-triol
is: HMDB12455
has only substance units: false
initial amount: NaN

metaR NDPK6n
product: MODEL1310110008#
fast: false
type: Reaction
reactant: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is described by: ECO:0000304
kinetic law: MODEL1310110008#
reversible: true
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176

metaM hx2coa m
is: http://identifiers.org/pubchem.compound/11966188
constant: false
is: C05998
boundary condition: false
is: HMDB06870
name: trans-Hex-2-enoyl-CoA
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
type: Species

metaR NACHEX8ly
kinetic law: MODEL1310110008#
is described by: ECO:0000000
reversible: false
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110008#
reactant: MODEL1310110008#
fast: false

metaR 5ADTSTSTERONEtr
type: Reaction
reactant: MODEL1310110008#
is: SBO:0000185
name: 5 alpha dihydrotesterone intracellular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
kinetic law: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000

metaM pail345p hs n
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
is: SBO:0000247
type: Species
is: CHEBI:57836
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)

http://identifiers.org/biomodels.db/MODEL1310110008#_2ea3e86a_2f47_4214_8805_6e58e78362b0
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: UGP2
is encoded by: hsa:7360
type: Species
initial concentration: NaN
constant: false

metaR S6TASE22ly
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
name: galactose-6-sulfate sulfatase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: true
is: SBO:0000176
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
product: MODEL1310110008#

metaR r0472
kinetic law: MODEL1310110008#
reversible: true
reactant: MODEL1310110008#
product: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

http://identifiers.org/biomodels.db/MODEL1310110008#_55591a26_a010_442c_a823_56ed28b60e20
is encoded by: hsa:4514
is encoded by: hsa:1346
is encoded by: hsa:1351
has part: Q96KJ9
has part: Q7Z4L0
has part: H0UI06
has only substance units: false
constant: false
is encoded by: hsa:1339
is encoded by: hsa:9167
is encoded by: hsa:1329
is encoded by: hsa:341947
is encoded by: hsa:1327
has part: P20674
is encoded by: hsa:4513
has part: P00414
is: SBO:0000297
is encoded by: hsa:1347
is encoded by: hsa:9377
is encoded by: hsa:1345
is encoded by: hsa:4512
has part: Q7GXZ8
initial amount: NaN
has part: P13073
boundary condition: true
is encoded by: hsa:170712
has part: P24311
has part: Q53YB7
is encoded by: hsa:1350
has part: P14854
type: Species
has part: Q6FGA0
has part: P12074
has part: Q8TF08
has part: Q7GXY8
has part: P09669
initial concentration: NaN
is encoded by: hsa:1337
is encoded by: hsa:1340
is encoded by: hsa:125965
has part: Q53XN1
is encoded by: hsa:84701
has part: P24310
is encoded by: hsa:1349
has part: P15954
has part: Q6YFQ2
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: Q02221

metaR NTD8
modifier: MODEL1310110008#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.5
notes: GENE_ASSOCIATION: (22978.1) or (30833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
product: MODEL1310110008#
is: SBO:0000176
reactant: MODEL1310110008#
reversible: false
kinetic law: MODEL1310110008#
type: Reaction
fast: false
name: 5'-nucleotidase (dGMP)

http://identifiers.org/biomodels.db/MODEL1310110008#_5f84c81a_9877_4b5f_87f7_aa133e6ff7e2
is encoded by: hsa:5151
is: O60658
has only substance units: false
constant: false
name: PDE8A
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaM CE0785 m
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:57795
name: cis,cis-myristo-5,8-dienoyl-CoA
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
is: SBO:0000247

metaR AG13T10g
reactant: MODEL1310110008#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110008#
type: Reaction
reversible: false
product: MODEL1310110008#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110008#_45341414_bbe3_4e82_91eb_215021645635
constant: false
initial amount: NaN
is encoded by: hsa:131669
name: UROC1
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q68CJ7
type: Species
initial concentration: NaN

metaM adrncoa m
is: SBO:0000247
type: Species
is: C16170
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: adrenyl coenzyme A
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205480
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_ba64783e_0a09_4a45_a9c5_130369d321b2
name: SULT1A1
type: Species
has only substance units: false
is encoded by: hsa:6817
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaM o2s m
type: Species
initial amount: NaN
is: C00704
has only substance units: false
constant: false
is: CHEBI:18421
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: Superoxide anion
is: HMDB02168

metaR DDCRNe
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydodecanoyl carnitine into extra cellular space
type: Reaction

metaR NDP3ex
is: SBO:0000176
name: nucleoside-diphosphatase (GDP), extracellular
type: Reaction
reactant: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.6.1.6
fast: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
is described by: ECO:0000269
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: false

metaR r1965
kinetic law: MODEL1310110008#
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport
reversible: false
fast: false
modifier: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000000
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR DIDPtn
reactant: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000185
type: Reaction
fast: false
name: dIDP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_dfd73e2a_e259_4dfc_9f07_377c76146ea1
initial concentration: NaN
name: NDUFB6
boundary condition: true
has only substance units: false
is encoded by: hsa:4712
initial amount: NaN
is: O95139
type: Species
constant: false
is: SBO:0000252

metaM glc D r
type: Species
initial concentration: 1.0
has only substance units: false
name: D-glucose
is: HMDB00122
initial amount: NaN
constant: false
is: CHEBI:4167
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
boundary condition: false
is: SBO:0000247

metaR HSD3A1r
is: SBO:0000176
is described by: ECO:0000269
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
modifier: MODEL1310110008#
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.225
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110008#_0f7d8607_1b91_47b2_a6fa_548ea87966fb
is: SBO:0000252
constant: false
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
name: RRM2B
is: Q7LG56
is encoded by: hsa:50484
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_9de2fcfd_871a_4b08_b741_b4d858acfa9e
is encoded by: hsa:30
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
name: ACAA1
is: Q96CA6

http://identifiers.org/biomodels.db/MODEL1310110008#_6ecfa6e2_25c2_4c58_95b0_9d90bd69448f
constant: false
boundary condition: true
type: Species
name: _H17063_1_m
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:H17063
has only substance units: false
initial amount: NaN

metaM digalside hs g
is: C06126
boundary condition: false
initial amount: NaN
constant: false
name: Digalactosylceramide
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
is: http://identifiers.org/pubchem.compound/8383
initial concentration: 1.0

metaR GHMT2rm
fast: false
product: MODEL1310110008#
name: glycine hydroxymethyltransferase, reversible, mitochondrial
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.1
is: SBO:0000176
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110008#_26890ee5_652a_4fd3_b7f0_cb495cfbc65b
is: Q9NR34
has only substance units: false
type: Species
is encoded by: hsa:57134
boundary condition: true
name: MAN1C1
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN

metaM docosahexcoa m
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
initial amount: NaN
name: 3,7,10,13,16,19-docosahexenoylcoa
boundary condition: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_1243bc27_ca41_4a41_a9b0_27c40dc83b9d
has only substance units: false
constant: false
name: SLC7A6
is: SBO:0000252
is: Q92536
type: Species
is encoded by: hsa:9057
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_37d64c6f_f595_42dd_a023_be17b0a26d98
is: Q9Y2A9
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:10331
name: B3GNT3
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_0ae4ed0a_4bea_4e9f_98ba_f8b5fcbc1fdf
initial amount: NaN
boundary condition: true
is: Q1ET61
type: Species
name: SULT1A3
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6818
constant: false

metaM aacoa x
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:57286
is: HMDB01484
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: SBO:0000247
initial concentration: 1.0
type: Species
name: acetoacetyl-CoA(4-)
initial amount: NaN

metaR FAOXC165C164x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:5-->C16:4)x
type: Reaction

metaR r1964
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
reversible: false
type: Reaction
fast: false
name: Y+LAT2 Utilized transport
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110008#

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaM lnlc e
type: Species
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
initial concentration: 1.0
is: HMDB00673
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: linoleate
constant: false
has only substance units: false
is: CHEBI:30245

http://identifiers.org/biomodels.db/MODEL1310110008#_974f0b08_7ac7_4fa5_9530_53776423f612
boundary condition: true
is encoded by: hsa:5153
constant: false
type: Species
initial amount: NaN
is: Q7Z364
name: PDE1B
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM hdcecrn c
is: SBO:0000247
is: HMDB00222
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
has only substance units: false
name: Hexadecenoyl carnitine
type: Species
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_a5c9d4f9_26a7_4572_a438_1fbde602455b
type: Species
is: SBO:0000252
is encoded by: hsa:34
initial concentration: NaN
is: P11310
boundary condition: true
initial amount: NaN
name: ACADM
constant: false
has only substance units: false

metaR EX c6crn
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hexanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_351dae61_e3c8_4008_ac47_687039a1c4ca
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: Q8IWU9
constant: false
name: TPH2
is encoded by: hsa:121278

metaM ksi deg28 l
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I, degradation product 28
boundary condition: false
is: HMDB01354
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C104H170N7O85S3 CHARGE: -3
is: CHEBI:57455
has only substance units: false

metaR sink tetdece1coa LPAREN c RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDECE1COASINK
type: Reaction

metaM vacccrn c
has only substance units: false
constant: false
is: HMDB06351
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: Vaccenyl carnitine
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110008#_404040dc_f5b7_42a5_a381_abc5509e3a0a
is encoded by: hsa:205
initial concentration: NaN
is: P27144
initial amount: NaN
type: Species
constant: false
name: AK4
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR RE2973C
name: RE2973
is version of: http://identifiers.org/ec-code/2.7.1.154
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
product: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.137
reversible: true
kinetic law: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110008#
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.1.153

http://identifiers.org/biomodels.db/MODEL1310110008#_54d73de7_4212_4c91_a3bd_bcec4f0544a0
is: P16499
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:5145
type: Species
name: PDE6A
is: SBO:0000252

metaR r0145
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.3.1
modifier: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
reversible: true
kinetic law: MODEL1310110008#
fast: false
product: MODEL1310110008#
is described by: ECO:0000000

metaM tetdece1crn e
notes: FORMULA: C21H39NO4 CHARGE: 0
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
name: tetradecenoyl carnitine
is: HMDB02014
has only substance units: false
initial concentration: 1.0

metaM HC00342 m
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
boundary condition: false
name: cis-aconitate(3-)
is: SBO:0000247
constant: false
is: CHEBI:16383

metaR FACOAL180i
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
product: MODEL1310110008#
fast: false
kinetic law: MODEL1310110008#
reversible: false
name: C180 fatty acid activation
modifier: MODEL1310110008#
is: SBO:0000176
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_97c1ec0c_a9e1_4217_bac1_8eae228c429e
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:4710
constant: false
initial amount: NaN
name: NDUFB4
is: O95168
is: SBO:0000252
has only substance units: false

metaM 3sala c
constant: false
initial concentration: 1.0
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
is: CHEBI:61085
is: SBO:0000247
initial amount: NaN
name: 3-Sulfino-L-alanine
has only substance units: false
is: C00606
boundary condition: false
type: Species

metaR P45017A2r
is described by: ECO:0000134
product: MODEL1310110008#
type: Reaction
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.14.99.9
fast: false
modifier: MODEL1310110008#
name: Cytochrome P450 17A1
notes: GENE_ASSOCIATION: (1586.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.99.9 Confidence Level: 4 AUTHORS: PMID:12915666,PMID:7893148 NOTES:ER noted in locuslink ref - RETURN AND CHECK AFTER DEEPER LIT SEARCH NJ. PMID_12915666 quantifies kinetic parameters using microsomal proteins from fetal testicular tissue with tritiated hydroxy-pregnenolone as substrate
kinetic law: MODEL1310110008#
reversible: false
is: SBO:0000176

metaM o2s n
has only substance units: false
is: CHEBI:18421
is: HMDB02168
name: superoxide
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0

metaM C04849 e
is: SBO:0000247
is: CHEBI:57449
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
boundary condition: false
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: 1.0

metaM idp c
has only substance units: false
is: HMDB03335
initial amount: NaN
type: Species
is: SBO:0000247
name: IDP(3-)
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial concentration: 1.0
is: CHEBI:58280
boundary condition: false
constant: false

metaM HC00695 m
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
type: Species
name: S-Succinyldihydrolipoamide
constant: false
initial concentration: 1.0
is: CHEBI:17432
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR IDOAASE3ly
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
product: MODEL1310110008#
is described by: ECO:0000000
name: alpha-L-iduronidase, lysosomal
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.76
is: SBO:0000176
fast: false
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD

metaM HC01609 e
is: SBO:0000247
boundary condition: false
has only substance units: false
name: UroporphyrinogenI
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28766
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
constant: false
type: Species

metaM dttp n
boundary condition: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
has only substance units: false
name: dTTP
initial concentration: 1.0
initial amount: NaN
is: CHEBI:37568
type: Species
is: SBO:0000247
is: HMDB01342
constant: false
is: C00459

metaM lnlc c
is: CHEBI:30245
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
type: Species
initial concentration: 1.0
boundary condition: false
name: linoleate
has only substance units: false
is: HMDB00673
is: SBO:0000247
initial amount: NaN
constant: false

metaM 2dodtricoa x
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: C05279
type: Species
initial concentration: 1.0
name: 2,6,9-dodecatrienoylcoa
initial amount: NaN
is: HMDB11123

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_d69e5468_c85a_4c04_a4fd_5ec2e393cb20
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR r1966
type: Reaction
name: Y+LAT2 Utilized transport
reactant: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110008#
reversible: false
fast: false
modifier: MODEL1310110008#

metaR r2358
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110008#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110008#
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110008#

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

metaM ametam c
is: HMDB00988
is: SBO:0000247
has only substance units: false
boundary condition: false
name: S-Adenosylmethioninamine
constant: false
type: Species
is: C01137
is: CHEBI:57443
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137

metaR SUCCACT
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of succinate
type: Reaction

metaR HACD9m
modifier: MODEL1310110008#
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110008#
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
type: Reaction
product: MODEL1310110008#
fast: false
reversible: true
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid

metaR RE2974N
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
product: MODEL1310110008#
fast: false
name: RE2974
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000000

metaM tetdec2coa c
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
name: tetradecadienoylcoa
initial concentration: 1.0
is: HMDB02014
type: Species
is: SBO:0000247

metaR SFGTH
is: SBO:0000176
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is described by: ECO:0000269
reversible: true
type: Reaction
name: S-Formylglutathione hydralase
is version of: http://identifiers.org/ec-code/3.1.2.12
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
reactant: MODEL1310110008#
product: MODEL1310110008#
fast: false

metaR FAOXC2452256x
fast: false
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110008#
reversible: false
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:5,n-6 -> c22:5, n-6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
is: SBO:0000176

metaR RE2814M
fast: false
kinetic law: MODEL1310110008#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
product: MODEL1310110008#
name: RE2814
reactant: MODEL1310110008#

metaM 4mptnl c
name: 4-methylpentanal
type: Species
constant: false
boundary condition: false
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB01318
is: CHEBI:17998
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110008#_9ed62d6b_af8d_4c78_ad98_0804d70c4525
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:55229
type: Species
is: Q9NVE7
is: SBO:0000252
initial amount: NaN
name: PANK4
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_575c577d_864c_4d3f_8da9_3c32401b5413
boundary condition: true
initial amount: NaN
constant: false
name: _AI971023_1_c
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:AI971023
is: SBO:0000252

metaM 13dampp c
has only substance units: false
is: SBO:0000247
name: trimethylenediaminium
initial amount: NaN
is: CHEBI:57484
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
is: HMDB00002

metaR r0160
fast: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
reversible: false
is version of: http://identifiers.org/ec-code/2.1.3.2
product: MODEL1310110008#
type: Reaction
is described by: ECO:0000000
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
is: SBO:0000176
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:

metaM bildglcur r
boundary condition: false
is: HMDB03325
is: SBO:0000247
constant: false
type: Species
is: CHEBI:58471
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
has only substance units: false
initial amount: NaN
name: bis(beta-glucosyluronate)bilirubin
initial concentration: 1.0

metaM HC10852 r
name: palmitoleyl-CoA(4-)
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
is: SBO:0000247
is: CHEBI:61540

metaR r2359
reversible: true
fast: false
product: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM hpdca e
type: Species
initial amount: NaN
is: SBO:0000247
name: margarate
constant: false
initial concentration: 1.0
is: HMDB02259
is: CHEBI:32366
boundary condition: false
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_148123f1_92c5_4466_995d_25948f70fb46
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:F23536
name: _F23536_1_m
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110008#_96b7d212_b09d_48e5_a2d4_2897b0189cf1
is: Q9UHW9
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: SLC12A6
has only substance units: false
constant: false
is encoded by: hsa:9990
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_c558ea56_eaea_4ae6_8693_8f0dcc8ae4b3
is encoded by: hsa:AI761708
has only substance units: false
initial concentration: NaN
name: _AI761708_1_m
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species

metaM lnlncgcoa m
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: CHEBI:57363
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: gamma-linolenoyl-CoA(4-)
is: HMDB06368
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_7df85833_943e_4fbe_a6e2_0505f8277b3c
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:1583
is: G3XAD7
initial amount: NaN
boundary condition: true
name: CYP11A1
type: Species

metaR CYOR u10m
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000134
reactant: MODEL1310110008#
reversible: false
name: ubiquinol-6 cytochrome c reductase, Complex III
product: MODEL1310110008#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.92
fast: false
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
is: SBO:0000185
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#

metaR ESTSULT
is version of: http://identifiers.org/ec-code/2.8.2.1
reactant: MODEL1310110008#
reversible: false
is: SBO:0000176
product: MODEL1310110008#
is described by: ECO:0000269
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.8.2.4
name: Estrogen sulfotransferase
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6783.1) or (6817.4) or (6817.1) or (6817.3) or (6817.2) or (6817.5) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.4 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:8185618 NOTES:NJ

metaM arachcoa e
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB04258
constant: false
name: arachidyl coenzyme A
is: CHEBI:15527
type: Species
initial concentration: 1.0
has only substance units: false

metaR N3Tg
reversible: false
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
type: Reaction
is described by: ECO:0000000
product: MODEL1310110008#
modifier: MODEL1310110008#
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.122
fast: false

metaR KHK2
is version of: http://identifiers.org/ec-code/2.7.1.3
reactant: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.3 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
is described by: ECO:0000269
name: ketohexokinase (D-xylulose)
reversible: false
type: Reaction
product: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
modifier: MODEL1310110008#

metaR SIAASE2ly
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
fast: false
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
name: sialidase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
is described by: ECO:0000000

metaM rbt e
is: SBO:0000247
has only substance units: false
is: HMDB00508
boundary condition: false
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
name: D-ribitol
initial concentration: 1.0
constant: false
is: CHEBI:15963
initial amount: NaN

metaM CE5118 m
is: SBO:0000247
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
type: Species
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
is: CHEBI:57923

metaR EX s2l2n2m2masn LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: de-Fuc form of PA6 exchange
type: Reaction

metaM 4mptnl e
is: SBO:0000247
name: 4-methylpentanal
has only substance units: false
is: HMDB01318
constant: false
type: Species
is: CHEBI:17998
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_b942b133_9ba4_4960_814a_937a20d44f93
name: FUT8
constant: false
type: Species
is encoded by: hsa:2530
boundary condition: true
is: G3V5N0
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR TTDCPT1
product: MODEL1310110008#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1374.1) or (1375.2) or (126129.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110008#
fast: false

metaR P45019A1r
reactant: MODEL1310110008#
modifier: MODEL1310110008#
product: MODEL1310110008#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.14.14.1
name: aromatase
notes: GENE_ASSOCIATION: (1588.1) or (1588.2) SUBSYSTEM: Steroid metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:16322257 NOTES:Kinetic parameters determined for wild type aromatase and allozymes with tritiated androstenedione as substrate
is: SBO:0000176
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_5e1e62de_76e5_48e4_99d5_2758943475d9
is: P14618
is encoded by: hsa:5315
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
name: PKM2

metaM pnto R c
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
name: (R)-Pantothenate
type: Species
is: HMDB00210
is: CHEBI:7916
is: SBO:0000247
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568

metaR PIter
modifier: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110008#
name: phosphate transport, endoplasmic reticulum
is described by: ECO:0000212
reversible: true
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_da140920_16f0_470a_9519_9b53cd82fdf3
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5279
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
name: PIGC

http://identifiers.org/biomodels.db/MODEL1310110008#_7eacb8da_95a7_441d_86b0_a5afec7cfbee
initial concentration: NaN
constant: false
is encoded by: hsa:6576
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
name: SLC25A1
is: D9HTE9
has only substance units: false

metaR FAOXC226C225m
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

metaM CE4876 r
is: CHEBI:57923
constant: false
is: SBO:0000247
type: Species
name: delta12-Prostaglandin J2
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110008#_67b279cd_e614_4db0_8531_6c9bb8686457
name: _R51273_1_c
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:R51273

metaR RBTt
fast: false
name: ribitol transport via passive diffusion
kinetic law: MODEL1310110008#
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110008#
product: MODEL1310110008#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD

metaR TTDCPT2
name: carnitine transferase
is: SBO:0000176
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
reactant: MODEL1310110008#
fast: false
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
kinetic law: MODEL1310110008#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110008#_d07662ab_0555_4524_967f_70ac56a17238
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:498
type: Species
is: P25705
name: ATP5A1
constant: false
boundary condition: true
has only substance units: false

metaM udpglcur c
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
constant: false
initial concentration: 1.0
is: HMDB00935
name: UDP-D-glucuronate
type: Species
is: C00167
is: CHEBI:58052

metaM pheme c
has only substance units: false
initial amount: NaN
is: CHEBI:17627
type: Species
initial concentration: 1.0
boundary condition: false
is: C00032
is: HMDB03178
is: SBO:0000247
name: Protoheme
constant: false
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032

metaR THD1m
reversible: true
is version of: http://identifiers.org/ec-code/1.6.1.2
product: MODEL1310110008#
reactant: MODEL1310110008#
name: NAD(P) transhydrogenase
type: Reaction
notes: GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES:TDV (2-6-2003)
modifier: MODEL1310110008#
fast: false
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_6cb47e72_e0ef_4bc5_b31f_570f1d7ad3c4
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q5SPY7
type: Species
is encoded by: hsa:954
boundary condition: true
constant: false
name: ENTPD2
is: SBO:0000252

metaM arachcoa c
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
boundary condition: false
name: arachidyl coenzyme A
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15527
is: HMDB04258
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_d6ecfdd6_1b92_4ba4_a0cd_731e8c08a2de
is: SBO:0000252
is: Q9UHI5
name: SLC7A8
initial concentration: NaN
is encoded by: hsa:23428
constant: false
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false

metaM ksii core2 pre4 g
notes: FORMULA: C53H86N4O38X CHARGE: -1
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 4
is: CHEBI:58053
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: C00130
initial concentration: 1.0
is: HMDB00175

metaM 34dhoxmand m
is: SBO:0000247
has only substance units: false
is: CHEBI:27637
name: 3,4-Dihydroxymandelate
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
type: Species
initial amount: NaN
boundary condition: false
is: HMDB01866
constant: false
initial concentration: 1.0

metaM pnto R e
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: CHEBI:7916
has only substance units: false
is: HMDB00210
name: (R)-Pantothenate
initial concentration: 1.0
is: SBO:0000247

metaR r2354
reversible: true
fast: false
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110008#
product: MODEL1310110008#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_997819eb_8622_411a_9e49_1b1d98c1fdfd
boundary condition: true
has only substance units: false
is encoded by: hsa:3073
is: P06865
initial amount: NaN
name: HEXA
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110008#_122aecc7_5e26_430d_bd7f_1e2e5396dbce
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: ALOX5
has only substance units: false
is: P09917
constant: false
is encoded by: hsa:240
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110008#_0b541d84_8836_439f_b27e_ab4f69ffdbfd
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3632
has only substance units: false
boundary condition: true
initial concentration: NaN
name: INPP5A
type: Species
is: Q14642
constant: false

http://identifiers.org/biomodels.db/MODEL1310110008#_8ca4ca85_76b3_47b4_aac4_32ec0d75f5df
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: Q86YN1
initial concentration: NaN
name: DOLPP1
is encoded by: hsa:57171
is: SBO:0000252

metaR r1670
product: MODEL1310110008#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110008#
reversible: true
fast: false
kinetic law: MODEL1310110008#
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_2b589b90_ce7c_44ef_8d8f_d7080918ce25
constant: false
name: ATP2B2
has only substance units: false
is: Q4J699
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:491

metaR ACNACNGALGBSIDEtg
kinetic law: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000000
name: acnacngalgbside hs intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reversible: true
fast: false
reactant: MODEL1310110008#
product: MODEL1310110008#
type: Reaction

metaR r0892
modifier: MODEL1310110008#
is: SBO:0000185
name: Facilitated diffusion
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.27
reactant: MODEL1310110008#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110008#
type: Reaction
product: MODEL1310110008#
fast: false

metaR GLYtp
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
product: MODEL1310110008#
reversible: true
name: glycine passive transport to peroxisome
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_78e96f84_01d3_46bc_ad2e_1f43ac317b91
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:126328
name: NDUFA11
initial amount: NaN
is: C9JT23
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_f6a114f3_ef55_41df_8218_103906241ebb
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is: B4DKS0
initial concentration: NaN
is encoded by: hsa:6566
name: SLC16A1
type: Species

metaR BAAT3x
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110008#
type: Reaction
kinetic law: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000304
fast: false
modifier: MODEL1310110008#
reversible: false
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:third version analog added as per KEGG NJ
name: bile acid Coenzyme A: amino acid N-acyltransferase

metaR ETF
is: SBO:0000176
type: Reaction
product: MODEL1310110008#
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
reversible: false
fast: false
name: electron transfer flavoprotein
is described by: ECO:0000000

metaR r2355
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
reactant: MODEL1310110008#
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000185

metaM acnacngalgbside hs e
initial concentration: 1.0
is: CHEBI:3338
is: C00036
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00223
type: Species
name: disialyl galactosylgloboside
has only substance units: false
is: SBO:0000247
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110008#_f8d8609b_f7df_4a85_aca4_c5b0cd8b6516
initial concentration: NaN
initial amount: NaN
name: OPLAH
type: Species
is: O14841
is encoded by: hsa:26873
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true

metaM ocdca e
name: octadecanoate (n-C18:0)
type: Species
has only substance units: false
is: CHEBI:25629
constant: false
is: HMDB00827
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
is: C01530
initial concentration: 1.0
boundary condition: false

metaR LEUGLYPEPT1tc
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR A MANASEly
reactant: MODEL1310110008#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110008#
name: alpha-mannosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.24
reversible: false
fast: false
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_0170a3aa_7aaa_4614_a05c_3cd8d1950d25
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3418
name: IDH2
initial amount: NaN
is: P48735
is: SBO:0000252
has only substance units: false
type: Species

metaR URIt
name: uridine facilated transport in cytosol
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
type: Reaction
product: MODEL1310110008#
is described by: ECO:0000269
fast: false
reversible: true
reactant: MODEL1310110008#

metaR RE3347C
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
product: MODEL1310110008#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
name: RE3347

metaR HPDCACRNt
is described by: ECO:0000269
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
reactant: MODEL1310110008#
type: Reaction
reversible: false
is: SBO:0000185
name: heptadecanoate transport into the mitochondria
product: MODEL1310110008#
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ

metaR FAOXC102C101x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:1)x
type: Reaction

metaR RE3567C
fast: false
is: SBO:0000176
reversible: true
name: RE3567
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
product: MODEL1310110008#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_6f06344d_640f_48e4_aa47_c811827463c3
boundary condition: true
initial amount: NaN
constant: false
is: P14410
initial concentration: NaN
is encoded by: hsa:6476
has only substance units: false
is: SBO:0000252
type: Species
name: SI

metaR LINKDEG2ly
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
is described by: ECO:0000000
type: Reaction
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
name: degradation of proteoglycan linkage region, lysosomal
fast: false
reversible: false

metaM itaccoa m
type: Species
boundary condition: false
is: HMDB03377
constant: false
initial concentration: 1.0
has only substance units: false
name: itaconyl-CoA(5-)
is: CHEBI:57381
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
is: SBO:0000247
initial amount: NaN

metaM 2oxoadp m
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
has only substance units: false
name: 2-oxoadipate(2-)
is: HMDB00225
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:57499
constant: false
type: Species

metaM 3dodtricoa x
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: HMDB11123
is: SBO:0000247
boundary condition: false
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: C05279
name: 3,6,9-dodecatrienoylcoa

http://identifiers.org/biomodels.db/MODEL1310110008#_0b39f6e2_adf9_4a9d_90fe_22c4742dd2ec
is: SBO:0000252
is encoded by: hsa:6319
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: O00767
name: SCD

metaR r2356
fast: false
reversible: true
reactant: MODEL1310110008#
is: SBO:0000185
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
type: Reaction
product: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR FAOXC161C141x
kinetic law: MODEL1310110008#
product: MODEL1310110008#
reactant: MODEL1310110008#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C16:1-->C14:1)x
type: Reaction

metaM c81crn c
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB13324
boundary condition: false
has only substance units: false
notes: FORMULA: C15H27NO4 CHARGE: 0
constant: false
name: octenoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110008#_c954d389_72f1_49de_be5a_b9aa48ec29af
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:50484
is: Q7LG56
constant: false
has only substance units: false
name: RRM2B
is: SBO:0000252

metaR UDPGLCAter
type: Reaction
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110008#_90cad4e3_1fb1_43dc_92c3_4b5e549d55eb
has only substance units: false
constant: false
initial amount: NaN
name: NDUFA2
is: O43678
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4695
type: Species

metaM m1mpdol U c
type: Species
is: CHEBI:28067
initial amount: NaN
boundary condition: false
constant: false
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
notes: FORMULA: C1305H2140N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
initial concentration: 1.0
is: SBO:0000247

metaM pydam c
is: CHEBI:57761
is: C00534
is: SBO:0000247
type: Species
is: HMDB01431
initial amount: NaN
constant: false
boundary condition: false
name: Pyridoxamine
initial concentration: 1.0
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
has only substance units: false

metaR ACNACNGALGBSIDEte
name: acnacngalgbside hs transport
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
product: MODEL1310110008#
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#

metaR ICDHxm
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
name: Isocitrate dehydrogenase (NAD+)
is version of: http://identifiers.org/ec-code/1.1.1.41
kinetic law: MODEL1310110008#
fast: false
product: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (3421.2 and 3420.3 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.3 and 3421.1 and 3419.1) or (3421.1 and 3419.1 and 3420.2) or (3421.2 and 3419.1 and 3420.2) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.41 Confidence Level: 0 AUTHORS: PMID:10601238,PMID:14555658 NOTES:The reaction may be reversible. Strathern shows the reactions as irreversible. IF. Biochemical, Genetic
reversible: false
modifier: MODEL1310110008#

metaM acnacngalgbside hs c
name: disialyl galactosylgloboside
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: C00036
type: Species
constant: false
is: HMDB00223
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: CHEBI:3338

http://identifiers.org/biomodels.db/MODEL1310110008#_77e780d4_7de6_4fbe_9c66_cb9325d800e0
constant: false
is encoded by: hsa:5151
initial concentration: NaN
name: PDE8A
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species

metaM nh4 x
is: HMDB00051
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
is: C01342
is: CHEBI:28938
initial amount: NaN
name: Ammonium
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaM stcrn m
type: Species
has only substance units: false
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
name: stearoylcarnitine
constant: false
initial concentration: 1.0
is: HMDB00848
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR DTMPK
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.9
modifier: MODEL1310110008#
type: Reaction
name: dTMP kinase
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110008#
kinetic law: MODEL1310110008#
is: SBO:0000176
fast: false
is described by: ECO:0000269

metaM ksi pre21 g
name: keratan sulfate I biosynthesis, precursor 21
constant: false
initial concentration: 1.0
is: C00130
boundary condition: false
is: CHEBI:58053
initial amount: NaN
is: HMDB00175
has only substance units: false
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
is: SBO:0000247
type: Species

metaR r2357
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
is: SBO:0000185
type: Reaction
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110008#
reversible: true

metaM ocdca c
type: Species
is: CHEBI:25629
constant: false
is: HMDB00827
initial amount: NaN
is: SBO:0000247
name: stearate
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_653d7aff_270a_4771_b3af_08d7a8e0cb87
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
name: SLC7A11
is: Q9UPY5
is encoded by: hsa:23657

metaR r1671
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110008#
reversible: true
product: MODEL1310110008#
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
name: Y+LAT2 Utilized transport
fast: false
type: Reaction

metaR FAOXC2251836m
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110008#
name: Beta oxidation of fatty acid
type: Reaction
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110008#
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaR APOC LYS BTNP
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110008#
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110008#
name: proteolysis of apoC-Lys-btn
reactant: MODEL1310110008#
is: SBO:0000176
type: Reaction

metaM rbt c
is: HMDB00508
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
name: D-ribitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: CHEBI:15963

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110008#_0c76e4c5_52e3_4e94_9d0d_636806021d3f
initial amount: NaN
type: Species
boundary condition: true
constant: false
name: ATP5D
has only substance units: false
initial concentration: NaN
is encoded by: hsa:513
is: SBO:0000252

metaR CYTK14n
product: MODEL1310110008#
is described by: ECO:0000269
modifier: MODEL1310110008#
name: cytidylate kinase (dCMP,CTP),nuclear
fast: false
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110008#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110008#

metaM idp n
initial amount: NaN
initial concentration: 1.0
name: IDP(3-)
boundary condition: false
is: HMDB03335
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: SBO:0000247
type: Species
constant: false
has only substance units: false
is: CHEBI:58280

http://identifiers.org/biomodels.db/MODEL1310110008#_a00e0262_7a13_4626_af16_3942336dd283
type: Species
is: SBO:0000252
initial amount: NaN
is: Q13123
boundary condition: true
initial concentration: NaN
constant: false
name: IK
is encoded by: hsa:3550
has only substance units: false

metaR DHCR72r
product: MODEL1310110008#
modifier: MODEL1310110008#
reversible: false
kinetic law: MODEL1310110008#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
fast: false
is described by: ECO:0000269
name: 7-dehydrocholesterol reductase
type: Reaction
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/1.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110008#_32277f79_22bb_4da8_9215_9d983438a261
constant: false
is encoded by: hsa:22305
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
name: _22305_2_c
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110008#_f488987c_4aec_4172_a490_e1affb0b1c33
initial amount: NaN
is encoded by: hsa:HG2846-HT2983
has only substance units: false
name: _HG2846_HT2983_1_c
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species

metaR FADtru
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
product: MODEL1310110008#
reversible: false
name: FAD transporter, endoplasmic reticulum
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
type: Reaction

metaM 3docopencoa x
is: http://identifiers.org/pubchem.compound/24892790
name: 3,7,10,13,16-docosapentenoylcoa
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
has only substance units: false

metaM c81crn e
boundary condition: false
is: HMDB13324
is: SBO:0000247
has only substance units: false
name: octenoyl carnitine
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C15H27NO4 CHARGE: 0
initial concentration: 1.0

metaM ser D e
name: D-serine
is: CHEBI:16523
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
has only substance units: false
is: HMDB03406
constant: false

metaM xu1p D c
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h3,5-7,9H,1-2H2,(H2,10,11,12)/t3-,5-/m1/s1
is: SBO:0000247
name: D-Xylulose 1-phosphate
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB06534
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110008#_66863c88_2aca_45e4_888b_14e025b4726a
is encoded by: hsa:NOS2A
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial concentration: NaN
name: _NOS2A_1_e
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110008#_ec5d4266_1a7d_4ada_a65f_1ec700cdd7dc
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:T83654
has only substance units: false
name: _T83654_1_e
is: SBO:0000252
constant: false

metaR S6TASE25ly
modifier: MODEL1310110008#
kinetic law: MODEL1310110008#
name: galactose-6-sulfate sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110008#
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110008#

metaR UROLACer
product: MODEL1310110008#
reversible: true
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.19 Confidence Level: 1 AUTHORS: PMID:13587494 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
name: uronolactonase, endoplasmic reticulum
fast: false
type: Reaction

metaM 3mop e
is: CHEBI:28654
constant: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
name: 3-methyl-2-oxopentanoate
type: Species
is: HMDB00491
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR HEX10
kinetic law: MODEL1310110008#
name: hexokinase (D-glucosamine:ATP)
product: MODEL1310110008#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.2
is: SBO:0000176
reversible: false
modifier: MODEL1310110008#
type: Reaction
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/2.7.1.1
notes: GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
reactant: MODEL1310110008#

metaR AG13T4g
product: MODEL1310110008#
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
type: Reaction
reversible: false
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false

metaR INSTt4 2
kinetic law: MODEL1310110008#
modifier: MODEL1310110008#
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
fast: false
is described by: ECO:0000006
type: Reaction
is: SBO:0000185
reversible: true
name: inositol transport via sodium symport
reactant: MODEL1310110008#
product: MODEL1310110008#

metaR G14T14g
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110008#
reversible: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
product: MODEL1310110008#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reactant: MODEL1310110008#
kinetic law: MODEL1310110008#

http://identifiers.org/biomodels.db/MODEL1310110008#_52898adb_428c_486e_920c_4c6d1d4529e9
has only substance units: false
name: GCAT
initial concentration: NaN
is encoded by: hsa:23464
is: E2QC23
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110008#_4ff02677_7207_47b3_b724_88def0ee7b09
constant: false
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:23428
initial concentration: NaN
name: SLC7A8:SLC3A2
has only substance units: false
type: Species
has part: Q86U05
boundary condition: true

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110008#
reactant: MODEL1310110008#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaR UMPK3n
is: SBO:0000176
kinetic law: MODEL1310110008#
reversible: true
modifier: MODEL1310110008#
product: MODEL1310110008#
fast: false
reactant: MODEL1310110008#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
name: UMP kinase (UTP),nuclear
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR FRDPtr
reactant: MODEL1310110008#
type: Reaction
is: SBO:0000185
name: lipid, flip-flop intracellular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110008#
product: MODEL1310110008#

metaM lnlncgcoa r
initial amount: NaN
is: HMDB06368
type: Species
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
constant: false
is: SBO:0000247
is: CHEBI:57363
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: gamma-linolenoyl-CoA(4-)