metaR r2119
modifier: MODEL1310110007#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110007#_39c1f9e7_a4ec_4a4d_a183_21b8ae7cf134
type: Species
is encoded by: hsa:10400
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: PEMT
has only substance units: false
constant: false
is: SBO:0000252

metaM din e
is: HMDB00071
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: C05512
is: CHEBI:28997
name: Deoxyinosine
is: SBO:0000247
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaR r1538
kinetic law: MODEL1310110007#
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
modifier: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
reactant: MODEL1310110007#
type: Reaction
fast: false
is: SBO:0000185

metaR r0817
is version of: http://identifiers.org/ec-code/2.3.1.41
fast: false
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
is: SBO:0000185
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
type: Reaction
product: MODEL1310110007#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_9b43cb97_bd0d_48e1_93c6_14ffd0c84d28
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
name: ACAD9
is: Q9H845
initial amount: NaN
is encoded by: hsa:28976

http://identifiers.org/biomodels.db/MODEL1310110007#_bad5d177_96fb_4b9f_bc64_357def2fd7c4
has only substance units: false
type: Species
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P39656
name: DDOST
is: SBO:0000252
is encoded by: hsa:1650

metaM dcacoa x
is: C05274
name: Decanoyl-CoA (n-C10:0CoA)
initial concentration: 1.0
is: HMDB06404
is: CHEBI:61430
initial amount: NaN
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
constant: false
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247

metaM 4hexdtetcoa m
initial concentration: 1.0
constant: false
is: HMDB02288
name: 4,7,10,13-hexadecatetraenoylcoa
initial amount: NaN
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false

metaR IDOURte
is described by: ECO:0000134
name: L-iduronate transport, extracellular
reactant: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_7d5eb6aa_089a_4ac8_9a7e_1eac1ea87183
has only substance units: false
name: AACS
type: Species
is: SBO:0000252
is encoded by: hsa:65985
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q86V21

metaR 3MOX4HOXPGALDOX
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
is: SBO:0000176
reversible: false
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false
is described by: ECO:0000304
modifier: MODEL1310110007#
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase
type: Reaction
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM ppi x
initial amount: NaN
has only substance units: false
name: Diphosphate
is: HMDB00250
is: CHEBI:33019
initial concentration: 1.0
is: C00013
constant: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_0abe4ea6_6f4d_4b22_90dd_58b71b1f5271
is: SBO:0000252
name: HADH
boundary condition: true
constant: false
is encoded by: hsa:3033
type: Species
initial amount: NaN
initial concentration: NaN
is: Q16836
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_730de7ea_a13e_458e_9dc3_6823993f8cac
initial concentration: NaN
name: PLCB1
is encoded by: hsa:23236
type: Species
initial amount: NaN
boundary condition: true
is: Q9NQ66
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_3854299d_690d_4f25_82f8_ea2f47f281df
is: SBO:0000252
constant: false
is encoded by: hsa:125206
initial amount: NaN
initial concentration: NaN
name: SLC5A10
is: A0PJK1
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_9736400a_423b_4dde_8222_958dfabc8728
initial concentration: NaN
has only substance units: false
is encoded by: hsa:65010
is: SBO:0000252
is: Q9Y3Y1
type: Species
constant: false
boundary condition: true
name: SLC26A6
initial amount: NaN

metaR RE2069C
is: SBO:0000176
kinetic law: MODEL1310110007#
reversible: true
is described by: ECO:0000000
product: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
reactant: MODEL1310110007#
name: RE2069
fast: false

metaR r2118
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000000

metaR PVD3
kinetic law: MODEL1310110007#
fast: false
product: MODEL1310110007#
reversible: true
type: Reaction
is: SBO:0000176
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
is described by: ECO:0000134
name: Previtamin D3 formation

metaM Lcystin e
type: Species
is: HMDB00192
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: CHEBI:16283
is: SBO:0000247
name: L-cystine
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_bab4eec4_812f_41a7_b96c_67e3bcdc701a
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8801
is: SBO:0000252
type: Species
boundary condition: true
constant: false
name: SUCLG2
is: Q96I99
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_0bd91c0e_f490_4036_bd9f_61f9a8afa8ba
initial amount: NaN
name: PRDX1
has only substance units: false
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5052

http://identifiers.org/biomodels.db/MODEL1310110007#_2be1254e_7b62_4ece_bff3_32310ec0a45e
boundary condition: true
name: PAH
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:5053
is: P00439
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_0509ecd9_5496_4df6_9947_47b151e2e65d
initial amount: NaN
is: SBO:0000297
name: PAFAH1B2:PAFAH1B3
constant: false
boundary condition: true
has part: A8DPS7
is encoded by: hsa:5050
is encoded by: hsa:5049
has only substance units: false
initial concentration: NaN
has part: Q15102
type: Species

metaR MMMm
modifier: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
name: methylmalonyl-CoA mutase
reversible: true
product: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.99.2

metaR r0963
is described by: ECO:0000000
name: Facilitated diffusion
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
product: MODEL1310110007#
type: Reaction
is: SBO:0000185
reversible: false

metaM thmmp m
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:37575
is: HMDB02666
name: thiamine(1+) monophosphate(2-)
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C12H16N4O4PS CHARGE: -1 INCHI: InChI=1S/C12H17N4O4PS/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19)/p-1 EHMN_ABBREVIATION: C01081
initial amount: NaN

metaR r0899
product: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
fast: false
name: Amino acid transporter ATB0+ Facilitated diffusion
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110007#
reversible: true
type: Reaction

metaR PROt4 2 r
fast: false
is: SBO:0000185
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
reversible: true
name: Proline transport (sodium symport) (2:1)
is described by: ECO:0000006
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110007#
type: Reaction
modifier: MODEL1310110007#

metaM ksii core2 l
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: SBO:0000247
type: Species
name: keratan sulfate II (core 2-linked)
initial concentration: 1.0
is: CHEBI:57255
is: HMDB01014
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_fc9f4b14_08ef_4bd0_aecf_bc07a0903524
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:AA532636
is: SBO:0000252
type: Species
name: _AA532636_1_m

metaR NDP7er
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
reactant: MODEL1310110007#
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#

metaM ahcys m
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
constant: false
name: S-Adenosyl-L-homocysteine
type: Species
initial amount: NaN
is: C00021
is: HMDB00939
is: CHEBI:16680

http://identifiers.org/biomodels.db/MODEL1310110007#_d7db1870_15af_470f_bda5_4f3a25a2aee9
initial concentration: NaN
constant: false
is encoded by: hsa:10400
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q9UBM1
has only substance units: false
name: PEMT
type: Species

metaM nadp r
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: HMDB00217
name: Nicotinamide adenine dinucleotide phosphate
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:58349
constant: false
boundary condition: false
is: C00006
has only substance units: false

metaR EX dheas LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dehydroepiandrosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_da72e361_f0d9_4632_a375_f40df35119a9
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:AA278423
type: Species
name: _AA278423_1_c

http://identifiers.org/biomodels.db/MODEL1310110007#_47368ae1_de73_44f0_882f_983da1951f99
initial amount: NaN
type: Species
boundary condition: true
name: HAO1
is: Q9UJM8
is: SBO:0000252
is encoded by: hsa:54363
has only substance units: false
initial concentration: NaN
constant: false

metaM dhcholestanate m
initial concentration: 1.0
constant: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
has only substance units: false
boundary condition: false
is: HMDB00359
is: CHEBI:16577
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_19fbc2bd_c350_4f17_b87c_faa43a554c11
name: GALNT6
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q8NCL4
constant: false
is encoded by: hsa:11226
is: SBO:0000252
type: Species

metaR PPItx
type: Reaction
product: MODEL1310110007#
name: Diphosphate transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reversible: true
kinetic law: MODEL1310110007#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110007#
is: SBO:0000185

metaR r2198
kinetic law: MODEL1310110007#
product: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
is: SBO:0000185
modifier: MODEL1310110007#
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5

metaR IMPC
is version of: http://identifiers.org/ec-code/2.1.2.3
product: MODEL1310110007#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
kinetic law: MODEL1310110007#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110007#
name: IMP cyclohydrolase
modifier: MODEL1310110007#

metaR BAAT4x
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:fourth version analog added in similarity to BAAT1x, BAAT2x NJ
fast: false
type: Reaction
name: bile acid Coenzyme A: amino acid N-acyltransferase
modifier: MODEL1310110007#
reversible: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110007#
is: SBO:0000176

metaR FTCD
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
product: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
is: SBO:0000176
reversible: false
is described by: ECO:0000134
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
name: formimidoyltransferase cyclodeaminase
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.5

http://identifiers.org/biomodels.db/MODEL1310110007#_4c0129ed_cde8_4656_b8f4_7c75910c1fd2
type: Species
initial amount: NaN
is encoded by: hsa:759
is: SBO:0000252
is: P00915
name: CA1
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM chlstol r
is: SBO:0000247
name: 5alpha-cholesta-7,24-dien-3beta-ol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
constant: false
initial amount: NaN
is: CHEBI:16290
initial concentration: 1.0
is: HMDB06842
type: Species
has only substance units: false
boundary condition: false

metaM dcdp n
is: CHEBI:58593
is: HMDB01245
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
name: dCDP(3-)
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_ce3e6687_9190_4d43_9268_b84c3f38de1d
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
is: SBO:0000252
name: PDE8A
initial amount: NaN
is encoded by: hsa:5151

metaM m7masnB g
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C64H107N2O50X CHARGE: 0
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C05881

metaM HC02180 c
has only substance units: false
type: Species
is: SBO:0000247
name: thromboxane-b2
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
constant: false
is: CHEBI:28728
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM HC00460 c
name: 2,5-dihydroxybenzoate
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:58044
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_9477059b_1d63_4481_9421_8b9c16c15d60
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:5130
name: PCYT1A
is: SBO:0000252
is: P49585
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_f7ad9427_5485_4d1c_90c1_5e450e46df9e
is: P08842
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:412
name: STS
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_627ab3e4_43cd_44a7_be91_a2167ac12d07
boundary condition: true
name: TYMP
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P19971
is encoded by: hsa:1890
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_d4d69a9b_1bcc_4091_adcb_da95182cc745
is: P35219
type: Species
is encoded by: hsa:767
constant: false
initial concentration: NaN
initial amount: NaN
name: CA8
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM mlthf m
initial amount: NaN
constant: false
is: HMDB01533
is: C00143
is: CHEBI:15636
name: 5,10-Methylenetetrahydrofolate
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
initial concentration: 1.0
boundary condition: false

metaR r2046
modifier: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
is described by: ECO:0000000
fast: false
product: MODEL1310110007#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR RE2998M
product: MODEL1310110007#
reactant: MODEL1310110007#
reversible: false
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
fast: false
name: RE2998
modifier: MODEL1310110007#

metaM zym int2 r
boundary condition: false
is: SBO:0000247
type: Species
constant: false
is: CHEBI:52386
name: zymosterol intermediate 2
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1

metaM 3hbcoa m
name: (S)-3-hydroxybutanoyl-CoA(4-)
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:57316
is: HMDB01166

metaR GALASE9ly
type: Reaction
product: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110007#
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
reversible: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4

metaM kynate c
is: CHEBI:58454
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00715
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
initial concentration: 1.0
name: kynurenate

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaM dcdp m
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:58593
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
name: dCDP(3-)
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB01245
boundary condition: false

metaM chsterol c
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
has only substance units: false
constant: false
boundary condition: false
is: HMDB00067
name: cholesterol
type: Species
is: CHEBI:16113
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM pail4p hs c
constant: false
initial amount: NaN
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
is: CHEBI:58178
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR FAOXC121C10x
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_e9d60fb2_00ee_47f6_9c9d_1b4197780ceb
boundary condition: true
has only substance units: false
is encoded by: hsa:5052
constant: false
name: PRDX1
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN

metaR r2196
reversible: true
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110007#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
is: SBO:0000185

metaM doco13ecoa x
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/24892791
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
type: Species
name: 13-docosenoylcoa
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_0cfb59f0_926c_41ee_a392_59fec45068ce
constant: false
boundary condition: true
is: SBO:0000252
name: UCK2
is: Q9BZX2
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:7371

metaM nadp x
has only substance units: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
name: Nicotinamide adenine dinucleotide phosphate
type: Species
is: SBO:0000247
constant: false
is: C00006
boundary condition: false
is: HMDB00217
initial concentration: 1.0
is: CHEBI:58349
initial amount: NaN

metaR VALt5m
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110007#
name: Valine reversible mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
fast: false

metaM Lkynr c
has only substance units: false
type: Species
name: L-kynurenine
is: HMDB00684
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:16946
initial amount: NaN
constant: false
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328

metaR r2115
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110007#
fast: false
type: Reaction
modifier: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

metaM frdp r
is: CHEBI:175763
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00961
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
constant: false
name: Farnesyl diphosphate
is: C00448
initial concentration: 1.0
has only substance units: false

metaR GHMT2r
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
fast: false
is described by: ECO:0000269
reversible: true
product: MODEL1310110007#
kinetic law: MODEL1310110007#
name: glycine hydroxymethyltransferase, reversible
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.1.2.1
modifier: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_961cea50_4222_44dd_8b2a_1811549a6ea5
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: IDS
is: P22304
has only substance units: false
is encoded by: hsa:3423
is: SBO:0000252
constant: false
type: Species

metaM gsn c
name: Guanosine
type: Species
is: HMDB00133
initial amount: NaN
is: CHEBI:16750
initial concentration: 1.0
is: C00387
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387

metaM ksi deg25 l
constant: false
has only substance units: false
is: CHEBI:16953
initial concentration: 1.0
notes: FORMULA: C118H192N8O98S4 CHARGE: -4
is: SBO:0000247
is: HMDB00812
type: Species
initial amount: NaN
name: keratan sulfate I, degradation product 25
boundary condition: false

metaM oxa m
constant: false
is: HMDB02329
initial amount: NaN
type: Species
is: CHEBI:30623
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
has only substance units: false
name: oxalate(2-)

metaM pram c
initial concentration: 1.0
initial amount: NaN
type: Species
name: 5-Phospho-beta-D-ribosylamine
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
has only substance units: false
boundary condition: false
is: C03090
is: HMDB01128
constant: false
is: CHEBI:58681
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_8d20ba5c_b00a_4040_94ce_7e817877aba4
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:AI934540
name: _AI934540_1_c

metaR RE3006M
is described by: ECO:0000000
kinetic law: MODEL1310110007#
name: RE3006
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110007#
type: Reaction
reversible: true
fast: false
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176

metaR SADT
type: Reaction
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.1.25
product: MODEL1310110007#
is described by: ECO:0000269
fast: false
is: SBO:0000176
reversible: false
name: sulfate adenylyltransferase
reactant: MODEL1310110007#

metaR EX glyphe LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylphenylalaine
type: Reaction

metaR RE0690E
modifier: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110007#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is version of: http://identifiers.org/ec-code/1.4.3.22
name: RE0690
reactant: MODEL1310110007#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110007#_06be2193_28d9_4be8_b974_a7a8a75f60d1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:54963
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
name: UCKL1
constant: false
is: Q53HM1

http://identifiers.org/biomodels.db/MODEL1310110007#_5fed6bcb_c774_4743_b7b5_89625e9a3a62
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:AI222095
has only substance units: false
is: SBO:0000252
name: _AI222095_1_m
type: Species
initial amount: NaN

metaR TALA
is: SBO:0000176
type: Reaction
reactant: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
name: transaldolase
is described by: ECO:0000000
modifier: MODEL1310110007#
product: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
is version of: http://identifiers.org/ec-code/2.2.1.2

metaM ser L m
is: HMDB00187
type: Species
constant: false
is: CHEBI:17115
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
initial concentration: 1.0
name: L-serine
is: SBO:0000247

metaM HC00900 c
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:30860
type: Species
is: SBO:0000247
boundary condition: false
name: Methylmalonate
has only substance units: false

metaR r2197
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
modifier: MODEL1310110007#
fast: false
reversible: true
kinetic law: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110007#

metaM s2l2fn2m2masn e
is: C00255
boundary condition: false
constant: false
name: PA6
initial concentration: 1.0
is: CHEBI:3554
is: SBO:0000247
notes: FORMULA: C90H145N6O65X CHARGE: -2
type: Species
is: HMDB00244
initial amount: NaN
has only substance units: false

metaM guln r
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
name: L-gulonate
is: HMDB03290
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
type: Species
initial amount: NaN
is: CHEBI:13115

metaR C14STRr
is: SBO:0000176
product: MODEL1310110007#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.3.1.70
type: Reaction
kinetic law: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
name: C-14 sterol reductase
reversible: false
reactant: MODEL1310110007#
modifier: MODEL1310110007#

metaR GALASE14ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110007#
reversible: false
is described by: ECO:0000000
fast: false
modifier: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR PRISTANALtx
name: pristanal peroxisomal transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
reversible: true
fast: false
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_150e61d9_293f_42ee_a823_2d01c55e7fbf
boundary condition: true
initial amount: NaN
is: Q15067
has only substance units: false
constant: false
is encoded by: hsa:51
initial concentration: NaN
is: SBO:0000252
name: ACOX1
type: Species

metaM cholate c
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: CHEBI:29747
is: SBO:0000247
name: Cholate
initial amount: NaN
boundary condition: false
is: HMDB00619
type: Species

metaR r2114
is described by: ECO:0000000
fast: false
modifier: MODEL1310110007#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
kinetic law: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

metaR DHCR71r
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
fast: false
is described by: ECO:0000134
reversible: false
name: 7-dehydrocholesterol reductase
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.21
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176

metaM aacoa x
type: Species
is: HMDB01484
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57286
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
initial amount: NaN
name: acetoacetyl-CoA(4-)
boundary condition: false

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaM chsterol e
boundary condition: false
initial concentration: 1.0
name: cholesterol
is: SBO:0000247
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
initial amount: NaN
is: CHEBI:16113
is: HMDB00067
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_c85a7a62_c317_4c57_aee7_ee266955c5be
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: CD38
has only substance units: false
is: P28907
is encoded by: hsa:952
constant: false
initial concentration: NaN

metaR LEUKTRE4t
is described by: ECO:0000000
reactant: MODEL1310110007#
product: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: leukotriene E4 transport
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110007#
fast: false

metaR LTD4DP
type: Reaction
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
fast: false
product: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#
name: Leukotriene D4 dipeptidase
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_52a2f641_f85c_40a7_9267_f2447cb5e122
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:763
boundary condition: true
initial amount: NaN
is: P35218
name: CA5A

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_816d9b6f_65d8_4f8f_b980_e934fb394209
is: Q14435
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:2591
boundary condition: true
is: SBO:0000252
name: GALNT3
initial amount: NaN

metaR GCC2cm
kinetic law: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.4.4.2
modifier: MODEL1310110007#
name: glycine-cleavage complex (lipoamide), mitochondrial
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.8.1.4
product: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.10
reversible: true
fast: false

metaR r2117
is: SBO:0000185
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaR ADMDC
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000176
type: Reaction
reversible: false
name: adenosylmethionine decarboxylase
product: MODEL1310110007#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.1.1.50
fast: false
notes: GENE_ASSOCIATION: (262.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.50 Confidence Level: 4 AUTHORS: PMID:2460457 NOTES:
modifier: MODEL1310110007#

metaR r1116
is: SBO:0000185
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
type: Reaction
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
product: MODEL1310110007#
fast: false

metaM g6p c
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:61548
initial concentration: 1.0
constant: false
is: C00092
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
type: Species
name: D-Glucose 6-phosphate
is: HMDB01401

metaM retinal r
initial amount: NaN
is: SBO:0000247
is: CHEBI:15035
has only substance units: false
type: Species
initial concentration: 1.0
name: retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
boundary condition: false
is: HMDB01358
constant: false

metaR COAtn
kinetic law: MODEL1310110007#
is: SBO:0000185
reactant: MODEL1310110007#
name: coenzyme A transport, nuclear
reversible: true
is described by: ECO:0000000
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
fast: false

metaM ksii core2 e
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:17268
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: HMDB00211
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
name: keratan sulfate II (core 2-linked)

metaM gsn e
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
name: Guanosine
is: HMDB00133
initial amount: NaN
type: Species
is: CHEBI:16750
is: C00387
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR DHPM1
kinetic law: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.5.2.2
modifier: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000269
name: dihydropyrimidinase (5,6-dihydrouracil)
product: MODEL1310110007#
is: SBO:0000176

metaR HS4ly
is version of: http://identifiers.org/ec-code/3.10.1.1
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
modifier: MODEL1310110007#
is described by: ECO:0000000
reactant: MODEL1310110007#
type: Reaction
reversible: false
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000176
name: heparan-N-sulfatase, lysosomal
fast: false

metaM but e
is: HMDB00039
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
has only substance units: false
constant: false
name: butyrate
type: Species
is: CHEBI:17968
is: SBO:0000247

metaR O2tm
reversible: true
reactant: MODEL1310110007#
is: SBO:0000185
name: O2 transport (diffusion)
product: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
is described by: ECO:0000000

metaR r0960
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000185
fast: false
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
reversible: true
is described by: ECO:0000000

metaR r1980
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110007#
product: MODEL1310110007#
fast: false
reversible: false
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_9be6a365_4f89_4f4f_bd72_cc4606a7915d
type: Species
is: SBO:0000252
has only substance units: false
name: ADH4
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:127
is: P08319

metaR FAOXC18480m
reactant: MODEL1310110007#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110007#
name: Beta oxidation of fatty acid
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
product: MODEL1310110007#
reversible: false
is: SBO:0000176

metaR r2193
product: MODEL1310110007#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction

metaM ksii core2 deg3 l
is: CHEBI:12936
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
constant: false
name: keratan sulfate II (core 2-linked), degradation product 3
is: HMDB00143

metaM dgdp c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
name: dGDP
boundary condition: false
is: HMDB00960
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
constant: false
is: C00361
is: CHEBI:58595
has only substance units: false

metaR THMPPtm
fast: false
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110007#
name: Thiamine diphosphate transport in via anion antiport, mitochondria
is described by: ECO:0000000
reactant: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:12014993 NOTES:IT
product: MODEL1310110007#

metaR r2195
reactant: MODEL1310110007#
is: SBO:0000185
modifier: MODEL1310110007#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110007#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction

metaM accoa x
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: HMDB01206
is: SBO:0000247
is: C00024
is: CHEBI:57288
name: Acetyl-CoA
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: false

metaR r2116
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110007#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110007#

metaR r1117
name: Facilitated diffusion
type: Reaction
reversible: true
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
fast: false
is: SBO:0000185

metaM dhcholestanate r
is: CHEBI:16577
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00359
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: SBO:0000247

metaM cholate e
initial concentration: 1.0
constant: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
type: Species
name: Cholate
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:29747
is: HMDB00619
has only substance units: false

metaR FAOXC165C164m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_557d4ddb_26c0_4be7_b229_f3e375e3673c
type: Species
constant: false
is encoded by: hsa:6716
is: P31213
initial concentration: NaN
initial amount: NaN
name: SRD5A2
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_dad7e54d_6871_40d7_91dc_a9b2c560135d
has only substance units: false
initial concentration: NaN
name: DPAGT1
boundary condition: true
is encoded by: hsa:1798
is: SBO:0000252
type: Species
initial amount: NaN
constant: false

metaR COAtm
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
modifier: MODEL1310110007#
product: MODEL1310110007#
type: Reaction
name: CoA transporter
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000269
fast: false
reversible: true
is: SBO:0000185

metaM 5forthf c
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
is: HMDB01534
boundary condition: false
is: CHEBI:57456
type: Species
is: SBO:0000247
name: 5-Formiminotetrahydrofolate
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: C00664

metaM m3mpdol L c
initial amount: NaN
notes: FORMULA: C1480H2428N20O370P20 CHARGE: -20
constant: false
type: Species
boundary condition: false
is: CHEBI:37632
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human liver homolog

http://identifiers.org/biomodels.db/MODEL1310110007#_66e73732_735b_405a_a333_297b7acf6286
is encoded by: hsa:U37519
initial concentration: NaN
name: _U37519_1_m
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species

metaR PPItr
reversible: true
kinetic law: MODEL1310110007#
is: SBO:0000185
fast: false
product: MODEL1310110007#
reactant: MODEL1310110007#
name: Diphosphate transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
type: Reaction
is described by: ECO:0000000

metaM HC01403 m
is: CHEBI:28325
type: Species
constant: false
name: (S)-Hydroxydecanoyl-CoA
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
boundary condition: false
initial amount: NaN

metaR OCOAT1m
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (5019.1) or (64064.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.8.3.5 Confidence Level: 4 AUTHORS: PMID:10964512,PMID:11756565 NOTES:TDV
modifier: MODEL1310110007#
is: SBO:0000176
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
type: Reaction
name: 3-oxoacid CoA-transferase
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.8.3.5

metaR UROLACer
name: uronolactonase, endoplasmic reticulum
is described by: ECO:0000000
product: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.19 Confidence Level: 1 AUTHORS: PMID:13587494 NOTES:NCD
reactant: MODEL1310110007#
reversible: true
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_88e2a2e7_19ec_4224_beb3_beeee1f5d0d4
boundary condition: true
constant: false
is encoded by: hsa:2730
has only substance units: false
has part: E1CEI4
initial concentration: NaN
initial amount: NaN
has part: P48507
is: SBO:0000297
name: GCLC:GCLM
is encoded by: hsa:2729
type: Species

metaR LALDO
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110007#
is: SBO:0000176
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.1
kinetic law: MODEL1310110007#
fast: false
modifier: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_6fd7ff9c_90c8_4af6_bb70_e861163e641f
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3631
initial amount: NaN
name: INPP4A
boundary condition: true
is: Q96PE3

metaR r1640
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110007#
product: MODEL1310110007#
type: Reaction
reversible: true
is: SBO:0000185
modifier: MODEL1310110007#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaR COAtp
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110007#
name: coenzyme A transport, peroxisomal
is described by: ECO:0000000
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110007#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_5ac01b2e_e745_489c_a0b2_a8f3ed62dca5
is: SBO:0000252
initial amount: NaN
type: Species
name: PANK2
is encoded by: hsa:80025
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_fe3327e1_38e7_4545_8379_f0230576bebd
initial amount: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:AI469183
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: _AI469183_1_x

http://identifiers.org/biomodels.db/MODEL1310110007#_e40f7e57_9ea3_4573_8bbf_91ae1851271f
constant: false
boundary condition: true
has only substance units: false
is: Q99798
is: SBO:0000252
name: ACO2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:50
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_161cd603_2842_4f20_9866_b7a65b4f1bd2
boundary condition: true
name: SRM
is: P19623
is encoded by: hsa:6723
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
constant: false

metaR GLYPHEPEPT1tc
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycylphenylalanine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_02388776_f6c8_4e7a_8f8d_40721704d04c
is: Q53YE7
constant: false
is encoded by: hsa:4128
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: MAOA
type: Species
initial amount: NaN

metaM dcdp c
type: Species
is: C00705
name: dCDP
boundary condition: false
is: CHEBI:58593
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: HMDB01245
initial concentration: 1.0
constant: false
initial amount: NaN

metaR r2341
type: Reaction
product: MODEL1310110007#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
fast: false
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#

metaM pail4p hs n
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
constant: false
is: CHEBI:58178
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277

metaR ITCOALm
reactant: MODEL1310110007#
reversible: true
modifier: MODEL1310110007#
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.2.1.5
kinetic law: MODEL1310110007#
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.4
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_ed60e840_0517_4ff2_8cf1_c46e72d5a698
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
name: ALDH1A2
is: B4DZR2
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:8854

metaR GLCt2 2
modifier: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110007#
name: D-glucose transport in via proton symport
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:

metaM mlthf c
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: SBO:0000247
boundary condition: false
name: 5,10-Methylenetetrahydrofolate
constant: false
has only substance units: false
is: HMDB01533
is: C00143
initial amount: NaN
type: Species
is: CHEBI:15636
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_5e48ee06_a2e1_40a1_a24a_6f8f3ecc932f
type: Species
initial concentration: NaN
initial amount: NaN
is: O75355
is encoded by: hsa:956
boundary condition: true
name: ENTPD3
has only substance units: false
is: SBO:0000252
constant: false

metaR O2tn
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110007#
name: O2 nuclear transport
product: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaR 4HPRO LTte
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
is: SBO:0000185
fast: false
name: Transport of trans-4-hydroxy-L-proline
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_c827d09e_4325_454a_a5a8_7509a1614195
initial amount: NaN
is encoded by: hsa:4597
name: MVD
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: P53602
has only substance units: false

metaM dhcholestanate c
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
boundary condition: false
is: CHEBI:16577
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: HMDB00359
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_041cfc16_da86_4f62_b4d9_9c7b5209a507
type: Species
constant: false
name: AK5
is encoded by: hsa:26289
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_4e948e4b_1317_4d08_96ac_275e1d6d516a
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: _AA526438_1_c
constant: false
initial concentration: NaN
is encoded by: hsa:AA526438

metaR RE1796R
is version of: http://identifiers.org/ec-code/1.1.1.145
reactant: MODEL1310110007#
name: RE1796
reversible: true
is: SBO:0000176
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
modifier: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#
fast: false
type: Reaction

metaM orot c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:30839
has only substance units: false
is: HMDB00226
name: Orotate
is: C00295
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
boundary condition: false
type: Species

metaM hspg e
constant: false
initial amount: NaN
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
has only substance units: false
name: heparan sulfate proteoglycan
type: Species
is: HMDB00719
boundary condition: false
initial concentration: 1.0
is: CHEBI:15699
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_6509e8e7_7d36_46a2_ae9b_76dd9e5e013f
type: Species
boundary condition: true
is encoded by: hsa:5140
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
name: PDE3B
has only substance units: false
is: Q13370

metaM CE2424 m
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
initial amount: NaN
is: CHEBI:28387
is: HMDB11123
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
has only substance units: false
type: Species
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR THCHOLSTOICtm
type: Reaction
product: MODEL1310110007#
reversible: true
kinetic law: MODEL1310110007#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110007#
is: SBO:0000185
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ

metaM tym c
constant: false
has only substance units: false
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
is: SBO:0000247
is: CHEBI:327995
boundary condition: false
name: tyraminium
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00306

http://identifiers.org/biomodels.db/MODEL1310110007#_60d34d92_c6c0_467d_9448_e8de0a4e0890
name: ALDH3B2
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:222
constant: false
is: SBO:0000252
is: P48448
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_c95c20f8_0c7c_40c0_8f8f_ccdcc45ff3d6
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4697
initial concentration: NaN
initial amount: NaN
is: O00483
type: Species
name: NDUFA4
constant: false

metaM retinal c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:15035
is: HMDB01358
is: SBO:0000247
name: retinal
type: Species

metaM ppcoa x
is: SBO:0000247
type: Species
is: C00100
name: Propanoyl-CoA
boundary condition: false
is: HMDB01275
initial amount: NaN
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:57392

metaM accoa n
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57288
boundary condition: false
type: Species
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
name: acetyl-CoA(4-)
is: HMDB01206

metaR BTNPLm
type: Reaction
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/6.3.4.10
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
fast: false
is: SBO:0000176
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
reactant: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000000
reversible: false

metaM nad c
has only substance units: false
is: CHEBI:57540
is: C00003
is: SBO:0000247
type: Species
name: Nicotinamide adenine dinucleotide
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/3305
is: HMDB00902
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_8d5ed931_1191_416e_acad_661c8ab309c1
has only substance units: false
constant: false
is: SBO:0000252
is: O60547
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:2762
boundary condition: true
name: GMDS

metaM ksi deg22 l
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 22
notes: FORMULA: C132H214N9O111S5 CHARGE: -5
is: HMDB00812
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:16953

metaR O2St
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
product: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
reversible: true
name: superoxide anion transport via diffusion (extracellular)
reactant: MODEL1310110007#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_0a210dd1_c3f6_4a93_a20b_8950c96bf94b
initial concentration: NaN
name: _M68895_1_c
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:M68895
constant: false
is: SBO:0000252

metaM prostgd2 r
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
constant: false
is: HMDB01403
name: prostaglandin D2(1-)
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57406
type: Species
initial concentration: 1.0
initial amount: NaN

metaR r1642
reversible: true
type: Reaction
modifier: MODEL1310110007#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#

metaM galside hs l
has only substance units: false
is: CHEBI:12947
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
name: D-galactosyl-N-acylsphingosine
constant: false

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaR r0339
is version of: http://identifiers.org/ec-code/3.1.2.22
is described by: ECO:0000000
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
modifier: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
kinetic law: MODEL1310110007#
product: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.2.2
reversible: false

metaR COAtr
kinetic law: MODEL1310110007#
reversible: true
is: SBO:0000185
name: COA transporter, endoplasmic reticulum
fast: false
is described by: ECO:0000000
reactant: MODEL1310110007#
product: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

http://identifiers.org/biomodels.db/MODEL1310110007#_a4fa10de_9c12_4efa_80ef_c654b4097936
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is: B4DNK4
name: PKM2
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5315

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_15517211_1402_4420_ba55_0d1945a845c0
initial concentration: NaN
is: Q9HBF5
is encoded by: hsa:400410
boundary condition: true
is: SBO:0000252
name: ST20
constant: false
has only substance units: false
type: Species
initial amount: NaN

metaM thym e
constant: false
is: HMDB00262
initial concentration: 1.0
name: thymine
type: Species
is: SBO:0000247
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:17821

metaM 3mlda c
is: SBO:0000247
boundary condition: false
type: Species
is: C05828
initial concentration: 1.0
constant: false
name: 3-Methylimidazoleacetic acid
is: HMDB02820
is: http://identifiers.org/pubchem.compound/8122
has only substance units: false
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
initial amount: NaN

metaM accoa m
is: C00024
is: HMDB01206
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
name: Acetyl-CoA
is: CHEBI:57288
initial concentration: 1.0

metaM ppi n
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
name: diphosphate(3-)
is: CHEBI:33019
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
type: Species

metaM 5oxpro e
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57606
has only substance units: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
type: Species
name: 5-oxoprolinate
constant: false
is: HMDB00267

metaR r2343
type: Reaction
is described by: ECO:0000000
product: MODEL1310110007#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110007#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_0fd4619b_c9d5_4bb2_bf18_4010e6f4ba7e
initial concentration: NaN
is: P07195
has only substance units: false
name: LDHB
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:3945
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_00df6fd6_e2e0_4d7e_bc6e_e1ab3029aef8
is: SBO:0000252
is: P37268
initial amount: NaN
initial concentration: NaN
name: FDFT1
constant: false
type: Species
is encoded by: hsa:2222
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_a5bf7a28_9092_493c_9797_63d9f31ed71d
is encoded by: hsa:34
is: P11310
name: ACADM
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaR THYOXt
name: T4 transport via bicarbonate countertransport
fast: false
product: MODEL1310110007#
is: SBO:0000185
reactant: MODEL1310110007#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ

metaM s2l2fn2m2masn g
name: PA6
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00868
constant: false
is: CHEBI:57737
notes: FORMULA: C90H145N6O65X CHARGE: -2
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_25f57eb6_f4e5_4d03_8a53_df4fde899be5
initial concentration: NaN
is encoded by: hsa:26290
initial amount: NaN
is: Q9NY28
has only substance units: false
constant: false
boundary condition: true
type: Species
name: GALNT8
is: SBO:0000252

metaM ala B c
is: CHEBI:16958
is: HMDB00056
initial concentration: 1.0
name: beta-alanine
type: Species
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100

http://identifiers.org/biomodels.db/MODEL1310110007#_f2d1704a_f88e_41e0_b669_2198ae8af6d8
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110007#_0ad34629_a9bc_48b6_9991_3ab9cc83cd48
type: Species
is encoded by: hsa:84812
has only substance units: false
initial concentration: NaN
constant: false
is: Q9BRC7
initial amount: NaN
name: PLCD4
is: SBO:0000252
boundary condition: true

metaM g1p c
is: CHEBI:58601
is: C00103
is: SBO:0000247
initial amount: NaN
name: D-Glucose 1-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
type: Species
is: HMDB01586
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0

metaR r1641
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_6cdfb3a1_7ae3_4b06_9d4a_99dc17fb99b8
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: E9PCI1
is: SBO:0000252
name: ACP2
is encoded by: hsa:53
boundary condition: true
initial concentration: NaN

metaR O2tp
product: MODEL1310110007#
reactant: MODEL1310110007#
reversible: true
name: O2 transport, peroxisomal
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110007#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_61b291d2_cafc_4148_b304_7a81cf84a99a
constant: false
is: P04745
boundary condition: true
is encoded by: hsa:278
type: Species
is: SBO:0000252
name: AMY1C
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR BACCLm
reversible: false
is: SBO:0000176
product: MODEL1310110007#
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
is described by: ECO:0000254
reactant: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/6.3.4.10
kinetic law: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
fast: false

metaR FAOXC121x
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:1)x
type: Reaction

metaM thmmp c
initial concentration: 1.0
is: CHEBI:37575
is: SBO:0000247
is: C01081
initial amount: NaN
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
is: HMDB02666
boundary condition: false
type: Species
name: Thiamin monophosphate
has only substance units: false
constant: false

metaR FAOXC180
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110007#
product: MODEL1310110007#
reversible: false
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR DCYTt
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is: SBO:0000185
product: MODEL1310110007#
name: deoxycytidine transport via diffusion
fast: false

metaM ppi m
is: CHEBI:33019
is: HMDB00250
type: Species
initial concentration: 1.0
has only substance units: false
name: Diphosphate
is: SBO:0000247
is: C00013
boundary condition: false
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
constant: false

metaM nad e
is: CHEBI:57540
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00902
name: NAD(1-)
initial amount: NaN
constant: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003

http://identifiers.org/biomodels.db/MODEL1310110007#_84ce5690_c6e3_4e6e_9197_2da02de9054c
type: Species
is encoded by: hsa:272
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: B7Z763
boundary condition: true
constant: false
name: AMPD3

metaR 5MTHFt2le
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110007#
is described by: ECO:0000134
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
name: 5-methyltetrahydrofolate transport via anion exchange
reversible: true
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_4e232d65_9fa0_409b_9859_c07dc8094c42
boundary condition: true
name: DGKH
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q86XP1
is encoded by: hsa:160851
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_169c8b8a_ae3c_48cc_9c0d_a4e2fd83a28c
has only substance units: false
constant: false
is encoded by: hsa:200010
initial concentration: NaN
name: SLC5A9
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is: E9PAK4

metaR S3TASE3ly
is: SBO:0000176
kinetic law: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
reversible: true
name: N-acetylglucosamine-3-sulfatase, lysosomal
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110007#

metaR r1644
reversible: true
product: MODEL1310110007#
is: SBO:0000185
modifier: MODEL1310110007#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaM dgdp m
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00960
initial amount: NaN
constant: false
initial concentration: 1.0
name: dGDP(2-)
is: CHEBI:58595

metaR r1429
fast: false
is: SBO:0000185
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
reversible: true
name: Free diffusion

metaM f1a g
is: HMDB02917
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
type: Species
notes: FORMULA: C22H37N2O15X CHARGE: 0
has only substance units: false
name: F1alpha
is: CHEBI:17151

http://identifiers.org/biomodels.db/MODEL1310110007#_1cedef7e_eda4_4031_bdf6_c5fdd311f756
type: Species
is encoded by: hsa:55350
has only substance units: false
initial amount: NaN
name: VNN3:VNN2:VNN1
is: SBO:0000297
constant: false
initial concentration: NaN
boundary condition: true

metaM lac D e
is: HMDB01311
boundary condition: false
name: (R)-lactate
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:16004
is: SBO:0000247
type: Species
has only substance units: false

metaM rib D e
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: CHEBI:16988
constant: false
name: D-ribose
initial concentration: 1.0
is: HMDB00283

metaM 3mlda e
type: Species
has only substance units: false
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/8122
constant: false
initial amount: NaN
is: HMDB02820
is: C05828
name: 3-Methylimidazoleacetic acid
boundary condition: false

metaR NACHEX24ly
reactant: MODEL1310110007#
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110007#
type: Reaction
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_99cf4fe4_1ed6_434c_8def_a83c03f197e4
boundary condition: true
initial amount: NaN
is encoded by: hsa:4758
type: Species
name: NEU1
has only substance units: false
is: Q99519
is: SBO:0000252
initial concentration: NaN
constant: false

metaM so3 m
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: CHEBI:17137
is: SBO:0000247
name: hydrogensulfite
is: HMDB00240

metaR r1643
reactant: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110007#
is: SBO:0000185
modifier: MODEL1310110007#
fast: false

metaM dgdp n
initial concentration: 1.0
is: CHEBI:58595
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
constant: false
name: dGDP(2-)
boundary condition: false
has only substance units: false
is: HMDB00960
type: Species

metaM 7dhchsterol c
initial amount: NaN
is: HMDB00032
name: cholesta-5,7-dien-3beta-ol
is: CHEBI:17759
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_252a354d_42df_4583_b054_344ecc231df4
constant: false
is encoded by: hsa:53354
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: PANK1
has only substance units: false
type: Species
initial amount: NaN

metaM fe3 c
name: Fe3+
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: Fe CHARGE: 3
is: HMDB12943
has only substance units: false
constant: false
is: SBO:0000247

metaM ala B e
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: HMDB00056
constant: false
name: beta-alanine
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16958
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_eb5406d1_614e_454f_88f2_6f07b9416b6b
constant: false
is: P55084
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3032
has only substance units: false
type: Species
name: HADHB
initial amount: NaN

metaR GNDer
kinetic law: MODEL1310110007#
is: SBO:0000176
reactant: MODEL1310110007#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
name: phosphogluconate dehydrogenase, endoplasmic reticulum
fast: false
is described by: ECO:0000000
product: MODEL1310110007#

metaR DRIBt
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false
type: Reaction
reversible: true
name: deoxyribose transport via diffusion
is: SBO:0000185

metaM ksi deg33 l
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
is: HMDB00143
name: keratan sulfate I, degradation product 33
initial concentration: 1.0
is: CHEBI:12936
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_032ebf15_8aa1_4b2a_b4d5_4d9d2111635d
is: P04818
boundary condition: true
initial concentration: NaN
name: TYMS
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:7298
initial amount: NaN
has only substance units: false

metaR NACHEX22ly
type: Reaction
is described by: ECO:0000000
product: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110007#
is: SBO:0000176
modifier: MODEL1310110007#

metaR ACGAMK
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.1.59
fast: false
type: Reaction
name: N-acetylglucosamine kinase
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110007#
reversible: false
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
modifier: MODEL1310110007#

metaM s7p c
is: C05382
is: CHEBI:57483
type: Species
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB01068
name: Sedoheptulose 7-phosphate
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_415ff90f_8eb3_4a65_89c1_fbcaa1c853d6
is encoded by: hsa:11253
has only substance units: false
type: Species
name: MAN1B1
is: SBO:0000252
is: Q9UKM7
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM ser L e
initial amount: NaN
name: L-serine
has only substance units: false
is: CHEBI:17115
initial concentration: 1.0
is: HMDB00187
constant: false
type: Species
boundary condition: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_1d40fbb0_1fb0_4f87_96eb_bf7fa1a9980d
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: P31645
constant: false
type: Species
is encoded by: hsa:6532
boundary condition: true
name: SLC6A4

metaR FTHFL
modifier: MODEL1310110007#
name: Formate-tetrahydrofolate ligase
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.5.1.5
is: SBO:0000176

metaR M7MASNBterg
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110007#
name: m7masnB transport from endoplasmic reticulum to Golgi apparatus
reactant: MODEL1310110007#
reversible: false
product: MODEL1310110007#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaM adp x
initial amount: NaN
constant: false
is: HMDB01341
has only substance units: false
is: SBO:0000247
is: CHEBI:456216
boundary condition: false
name: ADP(3-)
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial concentration: 1.0
type: Species

metaM HC02180 e
is: CHEBI:28728
is: SBO:0000247
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
has only substance units: false
initial amount: NaN
name: thromboxane-b2
type: Species
initial concentration: 1.0
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_1c5c9332_12c2_4b19_9b7f_8b0f75120d1c
name: GPX5
has only substance units: false
constant: false
is encoded by: hsa:2880
initial concentration: NaN
boundary condition: true
type: Species
is: O75715
initial amount: NaN
is: SBO:0000252

metaM nadp m
is: SBO:0000247
boundary condition: false
is: HMDB00217
initial amount: NaN
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: C00006
type: Species
is: CHEBI:58349
name: Nicotinamide adenine dinucleotide phosphate
constant: false
has only substance units: false
initial concentration: 1.0

metaR r1646
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110007#
is described by: ECO:0000000
reversible: true
product: MODEL1310110007#
modifier: MODEL1310110007#
is: SBO:0000185

metaR PYNP2r
type: Reaction
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.3
name: pyrimidine-nucleoside phosphorylase (uracil)
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
modifier: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_d62b3953_e669_42a9_bad2_7b3ae93ea576
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: _HG2846_HT2983_1_c
boundary condition: true
constant: false
is encoded by: hsa:HG2846-HT2983

http://identifiers.org/biomodels.db/MODEL1310110007#_daa4a893_8133_49d4_8d8a_3040d0a91db1
type: Species
name: HK2
constant: false
is: P52789
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3099
initial concentration: NaN

metaR N3Tg
product: MODEL1310110007#
type: Reaction
modifier: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.122
is: SBO:0000176
kinetic law: MODEL1310110007#
reversible: false
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus

metaR r0480
reversible: true
kinetic law: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110007#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
product: MODEL1310110007#
fast: false
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103

http://identifiers.org/biomodels.db/MODEL1310110007#_3e622a9b_bb8e_405c_a1d2_2f32f3c9bfda
type: Species
is encoded by: hsa:5464
name: PPA1
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q15181
initial concentration: NaN
constant: false

metaM m7mpdol L r
notes: FORMULA: C1720H2828N20O570P20 CHARGE: -20
is: CHEBI:37636
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_f73955d5_8b53_47ec_9e59_d43ce006fdfa
is: Q4KWH8
type: Species
is encoded by: hsa:23007
name: PLCH1
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false

metaR LTC4CP
reversible: true
reactant: MODEL1310110007#
name: Leukotriene C4 carboxypeptidase
kinetic law: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
is: SBO:0000176
fast: false
product: MODEL1310110007#

metaM oxa x
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:30623
boundary condition: false
constant: false
name: oxalate(2-)
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial concentration: 1.0
is: HMDB02329
is: SBO:0000247

metaR r0968
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
reversible: false
product: MODEL1310110007#
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000185
name: Postulated transport reaction
type: Reaction

metaM hspg l
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
name: heparan sulfate proteoglycan
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:17899
is: HMDB01993

metaM lac D c
constant: false
has only substance units: false
is: HMDB01311
initial concentration: 1.0
is: CHEBI:16004
boundary condition: false
name: (R)-lactate
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1

metaR RE1796M
reversible: true
kinetic law: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
fast: false
reactant: MODEL1310110007#
is: SBO:0000176
product: MODEL1310110007#
is described by: ECO:0000000
modifier: MODEL1310110007#
name: RE1796
is version of: http://identifiers.org/ec-code/1.1.1.145

metaM din c
initial concentration: 1.0
is: SBO:0000247
name: Deoxyinosine
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
boundary condition: false
is: CHEBI:28997
is: C05512
type: Species
constant: false
is: HMDB00071
initial amount: NaN
has only substance units: false

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaM ppi r
boundary condition: false
initial amount: NaN
name: Diphosphate
is: CHEBI:33019
is: C00013
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00250
type: Species

metaR DCSPTN1COAtx
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110007#
reactant: MODEL1310110007#
name: fatty acid intracellular transport
type: Reaction
kinetic law: MODEL1310110007#

metaM chol n
type: Species
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial concentration: 1.0
is: CHEBI:15354
name: choline
is: HMDB00097
is: SBO:0000247
boundary condition: false

metaM orot e
type: Species
has only substance units: false
name: orotate
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: HMDB00226
boundary condition: false
initial amount: NaN
is: CHEBI:30839

metaM galside hs g
name: D-galactosyl-N-acylsphingosine
is: CHEBI:12947
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
type: Species
initial concentration: 1.0
constant: false

metaR r1645
product: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110007#
is: SBO:0000185
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
reversible: true

metaR r0670
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
fast: false
product: MODEL1310110007#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110007#_13d5338d_4e19_4ef8_9ac9_4a512d191e0d
is: Q8IW54
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:5138
initial concentration: NaN
is: SBO:0000252
name: PDE2A
type: Species
boundary condition: true

metaM fe3 e
is: HMDB12943
is: SBO:0000247
name: Fe3+
constant: false
is: CHEBI:29034
has only substance units: false
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN

metaR NAGLCAly
reactant: MODEL1310110007#
reversible: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110007#
product: MODEL1310110007#
name: N-acetylglucosaminidase, lysosomal
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
is described by: ECO:0000000

metaM thbpt4acam c
initial concentration: 1.0
is: CHEBI:15374
boundary condition: false
has only substance units: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
initial amount: NaN
type: Species
is: SBO:0000247
name: 4a-hydroxytetrahydrobiopterin
is: HMDB02281
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_578cf377_b3a8_4062_a2dd_fd146c676696
is: SBO:0000252
has only substance units: false
is: E9PEI9
is encoded by: hsa:4047
name: LSS
initial amount: NaN
type: Species
boundary condition: true
constant: false
initial concentration: NaN

metaM ksi deg41 l
is: HMDB00143
constant: false
notes: FORMULA: C34H58N2O26 CHARGE: 0
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:12936
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: keratan sulfate I, degradation product 41

http://identifiers.org/biomodels.db/MODEL1310110007#_567cba8c_1a46_493a_914b_278f06aea3bc
has part: B3KT19
is: SBO:0000297
constant: false
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5291
has part: B4DER4
name: PIK3CB:PIK3R1
is encoded by: hsa:5295

metaR GHMT2rm
reactant: MODEL1310110007#
fast: false
product: MODEL1310110007#
type: Reaction
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.1
name: glycine hydroxymethyltransferase, reversible, mitochondrial
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD

metaM ser L c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17115
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
boundary condition: false
is: HMDB00187
type: Species
constant: false
name: L-serine
is: SBO:0000247
has only substance units: false

metaM chol m
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00097
constant: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
boundary condition: false
is: CHEBI:15354
is: SBO:0000247
name: choline
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_0fb0adcf_5c14_4a3a_ae7d_c1a4924bb72f
has only substance units: false
is: P13866
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
name: SLC5A1
is encoded by: hsa:6523

metaR FACOAL206
product: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:NJ
name: fatty-acid--CoA ligase
reversible: true
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110007#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110007#

metaM hco3 m
is: SBO:0000247
initial concentration: 1.0
name: Bicarbonate
is: C00288
is: CHEBI:17544
initial amount: NaN
constant: false
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: HMDB00595

metaM Lcystin c
has only substance units: false
is: SBO:0000247
name: L-cystine
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB00192
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: CHEBI:16283
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_1dd85894_6bf2_4def_8fc5_5fef52e5ef1d
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
constant: false
name: GART
is: Q59HH3
is encoded by: hsa:2618

metaR r0160
fast: false
is version of: http://identifiers.org/ec-code/2.1.3.2
is described by: ECO:0000000
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
modifier: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_a3d6b8e1_4372_4ac7_9afb_ad526d9e5113
initial concentration: NaN
name: SLC12A5
constant: false
is encoded by: hsa:57468
has only substance units: false
is: SBO:0000252
type: Species
is: Q9H2X9
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_6e43cb8a_4c21_4cdc_be12_57984ae689c7
is: Q8WXF9
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
name: SLC2A11
is encoded by: hsa:66035
has only substance units: false

metaM biocyt m
type: Species
is: SBO:0000247
constant: false
is: HMDB03134
is: C05552
initial concentration: 1.0
name: Biocytin
initial amount: NaN
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: http://identifiers.org/pubchem.compound/7886
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_5b08201c_ed8a_4e68_b54c_0a94bd85031b
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:10637
initial concentration: NaN
name: LEFTY1
is: O75610

http://identifiers.org/biomodels.db/MODEL1310110007#_454b08ce_0232_458d_8249_563060018a64
initial concentration: NaN
is: Q5QPH3
type: Species
initial amount: NaN
name: ACSS2
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:55902
constant: false

metaM 4aphdob c
type: Species
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
initial amount: NaN
is: SBO:0000247
is: CHEBI:58147
initial concentration: 1.0
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
is: HMDB00978
has only substance units: false
boundary condition: false
constant: false

metaM malt e
is: C00208
is: CHEBI:17306
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
name: Maltose
initial amount: NaN
is: HMDB00163
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_a45ae84c_7c65_406b_bd50_70d77074b812
is: SBO:0000252
is encoded by: hsa:766
has only substance units: false
boundary condition: true
is: Q86YU0
type: Species
constant: false
name: CA7
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_1bda6937_660e_4d05_b89c_6c1b6ab083a1
is encoded by: hsa:6391
constant: false
initial amount: NaN
type: Species
is: Q99643
name: SDHC
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM lnlncgcoa m
initial concentration: 1.0
has only substance units: false
is: CHEBI:57363
is: SBO:0000247
name: gamma-linolenoyl-CoA(4-)
type: Species
is: HMDB06368
constant: false
boundary condition: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_47eb1202_f9bf_49cc_9323_fea032974609
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
name: PKLR
has only substance units: false
is: P30613
initial concentration: NaN
is encoded by: hsa:5313

metaM succ x
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:30031
boundary condition: false
has only substance units: false
constant: false
is: HMDB00254
initial amount: NaN
name: Succinate
is: C00042
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042

metaM hs deg3 l
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: heparan sulfate, degradation product 3
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
is: CHEBI:16126

http://identifiers.org/biomodels.db/MODEL1310110007#_d8bd7d6d_a09e_4034_b3b5_269bcd3eb769
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
constant: false
name: _83530_1_c
initial amount: NaN
is encoded by: hsa:83530
is: SBO:0000252

metaR r1635
type: Reaction
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
is: SBO:0000185
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110007#
fast: false

metaR BTNt2
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
fast: false
is described by: ECO:0000269
modifier: MODEL1310110007#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110007#
name: Biotin reversible transport via proton symport
kinetic law: MODEL1310110007#
reversible: true
product: MODEL1310110007#

metaR DGAT
is version of: http://identifiers.org/ec-code/2.3.1.20
kinetic law: MODEL1310110007#
fast: false
modifier: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
name: diacylglycerol acyltransferase
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
reactant: MODEL1310110007#
is: SBO:0000176
reversible: false

metaR 3MLDAt
kinetic law: MODEL1310110007#
is: SBO:0000185
fast: false
reactant: MODEL1310110007#
is described by: ECO:0000000
name: 3MLDA extracellular transport via diffusion
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11411609 NOTES:SAB
product: MODEL1310110007#

metaM HC01496 m
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
is: CHEBI:28095
boundary condition: false
is: SBO:0000247
name: 2-Amino-3-oxoadipate

http://identifiers.org/biomodels.db/MODEL1310110007#_12577e96_eb26_4940_bdd9_cbe7ba367086
is: Q70HW3
constant: false
name: SLC25A26
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:115286
has only substance units: false

metaM btn c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: CHEBI:3420
is: HMDB00030
name: Biotin
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
is: C00120
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_374fec1e_30cf_4dc5_a11e_1b71713bfb95
initial amount: NaN
is encoded by: hsa:377841
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
name: ENTPD8
has only substance units: false
is: Q5MY95
constant: false

metaR UGT1A10r
type: Reaction
reversible: true
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
is version of: http://identifiers.org/ec-code/2.4.1.17
fast: false
kinetic law: MODEL1310110007#
is: SBO:0000176
product: MODEL1310110007#
is described by: ECO:0000134
reactant: MODEL1310110007#
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified

http://identifiers.org/biomodels.db/MODEL1310110007#_a8507076_180a_4833_940b_d6ed4083838e
initial amount: NaN
name: ACADS
type: Species
is: SBO:0000252
is: P16219
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:35

http://identifiers.org/biomodels.db/MODEL1310110007#_08966a21_3e26_4813_aebd_f9b0557929a8
has only substance units: false
type: Species
name: _AA419122_1_c
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AA419122

http://identifiers.org/biomodels.db/MODEL1310110007#_f57f3642_1d2f_4b02_83cc_a6400c797ad6
name: MTMR1
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q13613
type: Species
constant: false
boundary condition: true
is encoded by: hsa:8776
initial concentration: NaN

metaM nadp c
boundary condition: false
initial concentration: 1.0
is: CHEBI:58349
is: C00006
has only substance units: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: SBO:0000247
name: Nicotinamide adenine dinucleotide phosphate
is: HMDB00217
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_18f908f6_62f8_4956_a289_1c0c21632755
boundary condition: true
name: SC5DL
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q6GTM5
initial amount: NaN
is encoded by: hsa:6309
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_506236a5_7a1a_4d84_9c59_c1e478fa5e66
is encoded by: hsa:51727
constant: false
initial amount: NaN
name: CMPK1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: B2R6S5
has only substance units: false
type: Species

metaR RE1903R
product: MODEL1310110007#
name: RE1903
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
kinetic law: MODEL1310110007#
is: SBO:0000176
reactant: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_c224f49d_56f0_48d4_b4cb_11c800060b6f
type: Species
initial amount: NaN
is encoded by: hsa:386757
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
name: SLC6A10P

http://identifiers.org/biomodels.db/MODEL1310110007#_59dee793_000e_4438_beb5_eeb7864437eb
constant: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AL048840
has only substance units: false
name: _AL048840_1_c
is: SBO:0000252

metaM leuktrC4 c
is: CHEBI:57973
type: Species
initial amount: NaN
is: HMDB01198
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
name: leukotriene C4(2-)
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_07f72dcd_11ac_4ae7_8452_1c6a7b7d9208
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:80704
constant: false
is: Q9BZV2
name: SLC19A3
initial concentration: NaN
type: Species

metaR CERT2rt
name: ceramide transport protein
reactant: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
modifier: MODEL1310110007#
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110007#

metaR DOLPMT3 Ler
is: SBO:0000176
product: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.4.1.260
modifier: MODEL1310110007#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
type: Reaction
kinetic law: MODEL1310110007#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false

metaR GLYSARCNc
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Hydrolysis of glycylsarcosine for uptake
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_3e6fd0c5_909b_4ae4_91af_a021133f26db
initial amount: NaN
is encoded by: hsa:11227
initial concentration: NaN
name: GALNT5
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
constant: false
is: A5PKZ1

metaR r1636
product: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110007#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110007#
is described by: ECO:0000000

metaR ACOAO7p
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
reactant: MODEL1310110007#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
modifier: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#

metaM ksi deg18 l
type: Species
is: HMDB00143
has only substance units: false
name: keratan sulfate I, degradation product 18
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:12936
initial amount: NaN
constant: false
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
boundary condition: false

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaR r0517
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110007#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
is described by: ECO:0000000
product: MODEL1310110007#
type: Reaction
reversible: true
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#

metaM nad m
boundary condition: false
is: HMDB00902
type: Species
initial concentration: 1.0
is: CHEBI:57540
is: SBO:0000247
is: C00003
initial amount: NaN
constant: false
name: Nicotinamide adenine dinucleotide
is: http://identifiers.org/pubchem.compound/3305
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_ed0c97ab_1bd7_4662_9a93_7f541a1ae8ab
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:2650
is: Q02742
name: GCNT1
initial concentration: NaN

metaM dhbpt c
is: CHEBI:20680
constant: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00038
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: 6,7-dihydrobiopterin

metaM creat c
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: HMDB00064
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:16919
is: SBO:0000247
initial amount: NaN
name: creatine

metaM udpgal c
is: SBO:0000247
name: UDP-D-galactose(2-)
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:58439
initial amount: NaN
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
has only substance units: false
constant: false
is: HMDB00302

metaR FATP2t
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
type: Reaction
name: fatty acid electroneutral transport
reversible: true
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false
is: SBO:0000185
product: MODEL1310110007#
reactant: MODEL1310110007#

metaM malt c
initial concentration: 1.0
boundary condition: false
is: HMDB00163
name: Maltose
is: SBO:0000247
constant: false
is: C00208
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
is: CHEBI:17306

metaR SO4tl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
is: SBO:0000185
product: MODEL1310110007#
type: Reaction
name: Sulfate transport (lysosome)
is described by: ECO:0000269
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_7f6496fd_27b5_4991_aca9_15abd6e07928
type: Species
is encoded by: hsa:57379
name: AICDA
has only substance units: false
constant: false
is: Q546Y9
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR r0483
kinetic law: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
product: MODEL1310110007#
reversible: true
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
reactant: MODEL1310110007#

metaM galside hs c
constant: false
initial amount: NaN
type: Species
is: CHEBI:12947
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
name: D-galactosyl-N-acylsphingosine

metaM adp n
name: ADP(3-)
type: Species
initial amount: NaN
constant: false
is: CHEBI:456216
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: HMDB01341
initial concentration: 1.0

metaR r1637
modifier: MODEL1310110007#
reversible: true
kinetic law: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110007#_c21aa0ed_60f0_44bc_9134_8d4ee559fba1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: HSD3B2
is: P26439
has only substance units: false
is encoded by: hsa:3284
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_31deaba6_1e55_4394_b57f_20dd12604a00
is: Q86VV3
type: Species
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:953
has only substance units: false
name: ENTPD1

metaM malthp e
constant: false
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041
is: C01936
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
name: maltoheptaose
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_670cf6f9_2d71_4d58_9e72_582f2826af14
name: SLC25A21
is: SBO:0000252
constant: false
type: Species
is: G3V4L5
has only substance units: false
boundary condition: true
is encoded by: hsa:89874
initial concentration: NaN
initial amount: NaN

metaR SPODM
name: superoxide dismutase
modifier: MODEL1310110007#
is: SBO:0000176
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.15.1.1
product: MODEL1310110007#
type: Reaction
fast: false
kinetic law: MODEL1310110007#
is described by: ECO:0000269
reversible: false

metaM ppcoa m
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial amount: NaN
type: Species
has only substance units: false
is: C00100
is: HMDB01275
initial concentration: 1.0
is: CHEBI:57392
name: Propanoyl-CoA
is: SBO:0000247
constant: false
boundary condition: false

metaR r1638
reversible: true
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110007#
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#

metaR EX pectindchac LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectin-deoxycholic acid complex
type: Reaction

metaR PGISr
kinetic law: MODEL1310110007#
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ
name: Prostaglandin I2 synthase
reactant: MODEL1310110007#
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.99.4
modifier: MODEL1310110007#
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_f099f441_5092_445b_8c9b_72e7b654f667
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1718
is: SBO:0000252
has only substance units: false
type: Species
name: DHCR24
initial amount: NaN
is: Q15392

metaR UMPK4n
reversible: true
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (GTP),nuclear
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110007#
type: Reaction
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_99c7ace7_29ae_437c_808d_3f19e14d5b83
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1582
name: CYP8B1
boundary condition: true
is: Q9UNU6
type: Species
has only substance units: false
constant: false

metaM lnlccoa c
is: HMDB01064
name: linoleic coenzyme A
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/5462164
has only substance units: false
is: SBO:0000247

metaM ppi e
is: CHEBI:33019
is: SBO:0000247
is: C00013
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
constant: false
boundary condition: false
name: Diphosphate
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_f20a2612_7822_454a_ba82_8512ef0d5499
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
name: ADCY6
is encoded by: hsa:112
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_4d8f50db_39ba_443d_8970_b3f274a7550f
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:728637
is: SBO:0000252
constant: false
initial concentration: NaN
name: _728637_1_c

metaM adp m
name: ADP
type: Species
boundary condition: false
is: HMDB01341
is: C00008
initial amount: NaN
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3310
is: CHEBI:456216
is: SBO:0000247
has only substance units: false

metaM btn e
boundary condition: false
constant: false
is: SBO:0000247
is: C00120
type: Species
initial concentration: 1.0
name: Biotin
has only substance units: false
is: HMDB00030
initial amount: NaN
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: CHEBI:3420

metaR r1434
reversible: false
fast: false
is: SBO:0000185
name: Transport reaction
type: Reaction
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110007#
is described by: ECO:0000000

metaR EX pect LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectins
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_8f691f0f_aaa4_4a6c_8188_538a61d02ad2
name: BPNT1
initial concentration: NaN
is encoded by: hsa:10380
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: O95861

metaM ala B m
name: beta-alanine
initial concentration: 1.0
initial amount: NaN
is: HMDB00056
is: CHEBI:16958
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
type: Species
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_157add7f_7ff0_4d42_8ab1_bb5ab0686d6e
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: ALDH7A1
constant: false
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:501
is: E7EPT3

metaR r2344
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110007#
reversible: true
kinetic law: MODEL1310110007#
is: SBO:0000185

metaR r1639
is: SBO:0000185
fast: false
modifier: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110007#
reversible: true
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_9e0755e2_94e3_4c28_871f_40d771eddc2d
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is: P19367
initial amount: NaN
type: Species
name: HK1
is encoded by: hsa:3098
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_ca1ba025_7013_4356_b225_b1f3675fc15a
has only substance units: false
boundary condition: true
initial amount: NaN
name: SLC27A5
is encoded by: hsa:10998
is: Q9Y2P5
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252

metaR NACHEX15ly
is described by: ECO:0000000
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
reversible: false
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110007#_caf42035_5908_45bc_b741_72c2b2b7d760
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:7359
initial concentration: NaN
boundary condition: true
name: _7359_1_c

metaR HSPGtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false
name: heparan sulfate transport, extracellular to lysosome
product: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_305d2e5d_0233_4364_9449_414230cd6e3f
boundary condition: true
constant: false
is: SBO:0000252
name: PC
initial amount: NaN
initial concentration: NaN
is: P11498
is encoded by: hsa:5091
type: Species
has only substance units: false

metaM frdp c
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00961
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: CHEBI:175763
type: Species
is: C00448
constant: false
name: Farnesyl diphosphate

metaM arach e
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB02212
name: arachidate
is: CHEBI:32360
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
boundary condition: false
initial concentration: 1.0

metaR AMETtd
fast: false
reversible: true
product: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
name: diffusion of S-Adenosyl-L-methionine
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR INSTt2r
kinetic law: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
fast: false
type: Reaction
modifier: MODEL1310110007#
is: SBO:0000185
reactant: MODEL1310110007#
name: inositol transport in via proton symport
product: MODEL1310110007#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110007#_c5b90333_b78a_4e9c_a4f4_c7cfbe244941
has only substance units: false
type: Species
is encoded by: hsa:6817
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: SULT1A1

metaR GLYAMDTRc
reversible: true
fast: false
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.1.4.1
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (2628.1) SUBSYSTEM: Urea cycle EC Number: 2.1.4.1 Confidence Level: 4 AUTHORS: PMID:8547310 NOTES:SAB c
type: Reaction
is: SBO:0000176
reactant: MODEL1310110007#
product: MODEL1310110007#
name: glycine amidinotransferase (c)
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110007#_2905e453_8018_4ace_b968_aa48a381fc6d
is: SBO:0000252
initial amount: NaN
type: Species
name: MTMR6
is encoded by: hsa:9107
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q9Y217
constant: false

metaR RE2659R
reactant: MODEL1310110007#
is: SBO:0000176
type: Reaction
product: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
is described by: ECO:0000000
name: RE2659

http://identifiers.org/biomodels.db/MODEL1310110007#_e8233746_faa4_487f_9273_bede3c8731bb
name: AMACR
boundary condition: true
type: Species
is: Q3KT79
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:23600
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_782bd53b_2b6f_44d3_b00d_cc7a46747ada
type: Species
initial concentration: NaN
is: SBO:0000252
name: _AA576959_1_c
constant: false
is encoded by: hsa:AA576959
boundary condition: true
initial amount: NaN
has only substance units: false

metaM rbt c
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
has only substance units: false
is: HMDB00508
boundary condition: false
constant: false
name: D-ribitol
type: Species
is: CHEBI:15963
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_8b4e1dfd_206c_4523_8abe_a66cc7da36b6
name: CA3
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is: P07451
boundary condition: true
initial concentration: NaN
is encoded by: hsa:761
constant: false

metaR PSERT
reactant: MODEL1310110007#
modifier: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
reversible: false
is: SBO:0000176
name: phosphoserine transaminase
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:
is version of: http://identifiers.org/ec-code/2.6.1.52
is described by: ECO:0000269
type: Reaction

metaM thym c
initial amount: NaN
is: C00178
constant: false
is: CHEBI:17821
is: HMDB00262
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
initial concentration: 1.0
name: Thymine
has only substance units: false

metaR UDPG4E
is: SBO:0000176
name: UDPglucose 4-epimerase
product: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
modifier: MODEL1310110007#
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/5.1.3.2

http://identifiers.org/biomodels.db/MODEL1310110007#_20e81baf_1765_4e26_9b17_1ce0af03a9a1
has only substance units: false
is encoded by: hsa:C7orf24
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: _C7orf24_1_m

metaR DHFR
reversible: true
fast: false
product: MODEL1310110007#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.5.1.3
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
name: dihydrofolate reductase
is described by: ECO:0000254

metaM phyt2ohcoa x
boundary condition: false
name: 2-hydroxyphytanoyl-CoA(4-)
is: HMDB01295
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)32(50)40(54)70-20-19-43-30(49)17-18-44-38(53)35(52)41(6,7)22-63-69(60,61)66-68(58,59)62-21-29-34(65-67(55,56)57)33(51)39(64-29)48-24-47-31-36(42)45-23-46-37(31)48/h23-29,32-35,39,50-52H,8-22H2,1-7H3,(H,43,49)(H,44,53)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/t26?,27?,28?,29-,32?,33-,34-,35+,39-/m1/s1 EHMN_ABBREVIATION: C07343
is: CHEBI:57334
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_5ba2f9e7_5732_4464_a3ab_d4fb91f1713e
is: Q9NUB1
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:84532
initial amount: NaN
is: SBO:0000252
name: ACSS1
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_49963a3f_415b_4e1a_8c2a_c08e5097c61a
initial concentration: NaN
constant: false
is encoded by: hsa:10606
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: PAICS
type: Species
is: P22234
boundary condition: true

metaR SMS
product: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000269
fast: false
is: SBO:0000176
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
name: Sphingomyelin synthase (homo sapiens)
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.7.8.27
type: Reaction
reversible: false

metaM malttr e
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
initial concentration: 1.0
is: HMDB01262
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
is: C01835
boundary condition: false
has only substance units: false
is: CHEBI:27931
name: maltotriose

metaR FAOXC183C163Gm
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

metaM CE1935 e
constant: false
initial amount: NaN
notes: FORMULA: C10H26N3O CHARGE: 3 INCHI: InChI=1/C10H23N3O/c11-5-3-8-12-6-1-2-7-13-9-4-10-14/h10,12-13H,1-9,11H2/p+3 EHMN_ABBREVIATION: CE1935
name: spermine monoaldehyde
is: HMDB02329
is: CHEBI:30623
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0

metaM itaccoa m
is: HMDB03377
type: Species
name: itaconyl-CoA(5-)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
is: CHEBI:57381
constant: false
boundary condition: false

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

metaM 4nph e
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
is: SBO:0000247
has only substance units: false
name: 4-nitrophenolate
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57917
is: HMDB01232
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_e2df5c70_db32_45a7_b410_f83abfbc6269
type: Species
boundary condition: true
constant: false
initial concentration: NaN
name: GMPS
is: P49915
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8833
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_9740fd95_6944_4f96_93a1_b503f1c362cf
is: P09669
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
name: COX6C
has only substance units: false
boundary condition: true
is encoded by: hsa:1345

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_f38cfe74_2ab8_4483_814f_b6cbc0da2d84
has only substance units: false
is encoded by: hsa:114805
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q8IUC8
name: GALNT13
initial amount: NaN

metaM glyc3p x
is: C00093
is: HMDB00126
is: CHEBI:57597
initial concentration: 1.0
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
name: Glycerol 3-phosphate
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species

metaM udpgal g
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:58439
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
name: UDP-D-galactose(2-)
is: HMDB00302
constant: false

metaR r2346
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
name: Organic anion transporter 5 Utilized transport

metaR ILEt5m
name: Isoleucine mitochondrial transport
kinetic law: MODEL1310110007#
fast: false
reversible: true
product: MODEL1310110007#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is described by: ECO:0000000
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_f6d24f57_b0ba_446e_a61b_93aebb044caa
type: Species
has only substance units: false
initial concentration: NaN
name: NDUFV2
is encoded by: hsa:4729
is: SBO:0000252
boundary condition: true
constant: false
is: P19404
initial amount: NaN

metaM hs deg22 l
initial concentration: 1.0
is: HMDB02704
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C37H56NO35S CHARGE: -3
is: CHEBI:21338
has only substance units: false
constant: false
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
type: Species

metaR FAOXC163C164Gm
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_1aa504bc_23aa_4f7b_8579_0b40afe773d1
is: SBO:0000252
type: Species
name: SLC2A12
initial amount: NaN
is encoded by: hsa:154091
has only substance units: false
is: Q8TD20
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_0aa53d5f_a934_4dd3_97aa_b404c69c8e46
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8854
is: SBO:0000252
boundary condition: true
is: O94788
name: ALDH1A2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_e48b5f87_9e36_4d57_b0be_2627fa7ef1f5
is: SBO:0000252
is: B2RB13
name: ACSL6
type: Species
initial amount: NaN
is encoded by: hsa:23305
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

metaM adp r
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: HMDB01341
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:456216
boundary condition: false
has only substance units: false
name: ADP(3-)
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_1791cb03_f1d9_4f41_ab2a_933d66f09433
constant: false
is: SBO:0000297
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4830
name: NME1:NME2
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_120cad79_d4ac_49a0_b5c4_d8cc8a3c4b69
is: P13804
initial amount: NaN
name: ETFA
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:2108

metaM arach c
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: arachidate
is: SBO:0000247
is: HMDB02212
is: CHEBI:32360
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
boundary condition: false
initial concentration: 1.0

metaM HC01406 m
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:28264
type: Species
initial concentration: 1.0
has only substance units: false
name: 3-Oxooctanoyl-CoA
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267

metaM 12ppd R c
initial amount: NaN
type: Species
is: HMDB01881
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
name: (R)-propane-1,2-diol
initial concentration: 1.0
is: CHEBI:28972
constant: false
boundary condition: false

metaR ACACT7p
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110007#
reversible: false
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
kinetic law: MODEL1310110007#
is: SBO:0000176
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal

http://identifiers.org/biomodels.db/MODEL1310110007#_d63e7ca2_0730_4de1_a23e_c0824bdd3586
name: PLCG1
type: Species
initial amount: NaN
is encoded by: hsa:5335
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q9UFY1
constant: false
initial concentration: NaN

metaR GUAt
type: Reaction
modifier: MODEL1310110007#
name: Guanine transport
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
product: MODEL1310110007#
reversible: true
reactant: MODEL1310110007#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110007#
is: SBO:0000185

metaR r1435
type: Reaction
reactant: MODEL1310110007#
is: SBO:0000185
reversible: false
fast: false
kinetic law: MODEL1310110007#
name: Transport reaction
product: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:

metaR r1540
product: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
modifier: MODEL1310110007#
is described by: ECO:0000000

metaR FAOXC164m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaM CE2435 m
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57795
constant: false
has only substance units: false
initial amount: NaN
name: trans,cis-deca-2,4-dienoyl-CoA

metaM rbt e
is: SBO:0000247
name: D-ribitol
initial amount: NaN
is: HMDB00508
is: CHEBI:15963
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species

metaR r2347
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false
is: SBO:0000185
reversible: true
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110007#
is described by: ECO:0000000

metaR BILGLCURtr
kinetic law: MODEL1310110007#
is: SBO:0000185
reactant: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
name: glucuronidated compound transport

http://identifiers.org/biomodels.db/MODEL1310110007#_7cec6700_4c78_464f_a822_0467a0230443
type: Species
initial amount: NaN
name: DGKB
boundary condition: true
is encoded by: hsa:1607
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q9Y6T7

http://identifiers.org/biomodels.db/MODEL1310110007#_9734ea52_eaa4_4627_9579_2455e53f6d9d
is encoded by: hsa:3418
initial concentration: NaN
has only substance units: false
is: P48735
boundary condition: true
initial amount: NaN
name: IDH2
type: Species
constant: false
is: SBO:0000252

metaR CYSGLUexR
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110007#
name: L-cysteine/L-glutamine reversible exchanger
product: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
is: SBO:0000185
reversible: true
is described by: ECO:0000304
modifier: MODEL1310110007#

metaR SGPL12r
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.1.2.27
product: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000176
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
is described by: ECO:0000304
name: Sphingosine-1-phosphate lyase

metaR r0488
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000176
reactant: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:

metaR r0512
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
modifier: MODEL1310110007#
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
reactant: MODEL1310110007#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000176
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110007#
product: MODEL1310110007#

metaR CYTK14n
product: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
name: cytidylate kinase (dCMP,CTP),nuclear
is described by: ECO:0000269
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR AHC
notes: GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
type: Reaction
reversible: true
modifier: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.3.1.1
kinetic law: MODEL1310110007#
fast: false
is described by: ECO:0000269
name: adenosylhomocysteinase
product: MODEL1310110007#

metaR GAL3ST11
fast: false
type: Reaction
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.8.2.11
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
product: MODEL1310110007#
reversible: false
name: Galactosylceramide sulfotransferase
modifier: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000000

metaM nadp e
constant: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 INCHI: InChI=1S/C21H28N7O17P3/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39)/p-3/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00217
is: CHEBI:58349
initial amount: NaN
type: Species
boundary condition: false
name: NADP+(3-)

http://identifiers.org/biomodels.db/MODEL1310110007#_bdd32efe_0e59_402d_a877_2b658c5a7635
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is: O43426
is encoded by: hsa:8867
initial concentration: NaN
name: SYNJ1
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_22d59fa7_e138_428c_bbdb_67aafd380a28
type: Species
name: ST3GAL2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6483
is: Q16842
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR G13MT L
kinetic law: MODEL1310110007#
is described by: ECO:0000000
modifier: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
product: MODEL1310110007#
name: Glycolipid 1,3-alpha-D-mannosyltransferase (liver)
reversible: false
fast: false
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.132

http://identifiers.org/biomodels.db/MODEL1310110007#_1450a3df_fcf8_4171_81b4_9ff6e9866d53
has only substance units: false
type: Species
initial amount: NaN
is: Q08499
is: SBO:0000252
constant: false
name: PDE4D
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5144

metaR CYTK6
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110007#
reversible: true
name: cytidylate kinase (CMP,CTP)
kinetic law: MODEL1310110007#
fast: false
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_4540e2b5_07f7_43ff_8990_d07941fa7218
is: Q15102
is encoded by: hsa:5050
is: SBO:0000252
constant: false
name: PAFAH1B3
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false

metaM ura c
type: Species
is: C00106
boundary condition: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: CHEBI:17568
is: HMDB00300
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
name: Uracil
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_5fbab92d_dc13_45bc_b315_e9adce573d44
has only substance units: false
initial amount: NaN
name: OGDHL
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:55753
type: Species
is: Q9ULD0

metaM xoldioloneh c
is: SBO:0000247
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
constant: false
initial concentration: 1.0
is: HMDB06887
boundary condition: false
type: Species
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
initial amount: NaN
is: CHEBI:2288
has only substance units: false

metaM air c
is: HMDB01235
constant: false
type: Species
is: CHEBI:58592
initial concentration: 1.0
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
is: SBO:0000247
is: C03373
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
has only substance units: false
boundary condition: false
initial amount: NaN

metaR r0668
is: SBO:0000176
modifier: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.2.19
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
type: Reaction
reversible: true
fast: false
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
kinetic law: MODEL1310110007#
product: MODEL1310110007#

metaR RTOTAL3FATPc
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal3 by enterocytes
type: Reaction

metaR ALOX52
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
product: MODEL1310110007#
name: Arachidonate 5-lipoxygenase
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.34
fast: false
modifier: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_29687a38_2ac3_4bbe_b353_c1dba01ef64d
initial concentration: NaN
is encoded by: hsa:55350
name: VNN3
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true

metaM ksi deg19 l
type: Species
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I, degradation product 19
is: HMDB00812
has only substance units: false
notes: FORMULA: C146H236N10O124S6 CHARGE: -6
boundary condition: false
is: CHEBI:16953
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_cb05b7af_ad7e_4246_a268_19e39f64d6ec
initial amount: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:3295
is: E9PB82
has only substance units: false
is: SBO:0000252
name: HSD17B4
initial concentration: NaN

metaR r0055
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.4.2.7
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.8
type: Reaction
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
is described by: ECO:0000000
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
reactant: MODEL1310110007#
reversible: true
is: SBO:0000176
product: MODEL1310110007#

metaR GLCAASE8ly
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.31
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
reactant: MODEL1310110007#
type: Reaction
fast: false
modifier: MODEL1310110007#
name: beta-glucuronidase, lysosomal
is described by: ECO:0000269
product: MODEL1310110007#

metaR ALDD2y
is version of: http://identifiers.org/ec-code/1.2.1.36
is described by: ECO:0000000
reactant: MODEL1310110007#
fast: false
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110007#
name: aldehyde dehydrogenase (acetaldehyde, NADP)
product: MODEL1310110007#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110007#_5c70fc54_1532_41bf_9914_f4cd876e3a1d
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: E7EQF2
is: SBO:0000252
constant: false
name: CROT
is encoded by: hsa:54677
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_7b235820_6723_4f60_9392_6c82a687492e
initial concentration: NaN
is encoded by: hsa:956
name: ENTPD3
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: O75355
type: Species

metaM prostge1 e
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB01442
type: Species
constant: false
boundary condition: false
name: prostaglandin E1(1-)
is: CHEBI:57397

metaM adprib c
type: Species
is: HMDB01178
is: SBO:0000247
is: CHEBI:57967
boundary condition: false
has only substance units: false
notes: FORMULA: C15H21N5O14P2 CHARGE: -2 EHMN_ABBREVIATION: C00301
constant: false
initial amount: NaN
is: C00301
name: ADPribose
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_290b3b6d_776c_40e0_9c83_e0067a16f472
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: Q9NYW8
type: Species
is: SBO:0000252
is encoded by: hsa:57786
initial concentration: NaN
name: RBAK

metaR r2110
is: SBO:0000185
product: MODEL1310110007#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110007#
fast: false
modifier: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_0e484f8a_1fa0_4277_ba8d_2163816c50ac
is encoded by: hsa:5296
boundary condition: true
type: Species
has part: O00459
constant: false
is: SBO:0000297
is encoded by: hsa:5290
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: PIK3CA:PIK3R2
has part: P42336

metaM dece3coa m
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
name: 3-decenoylcoa
initial concentration: 1.0
is: SBO:0000247

metaR CYTK5
name: cytidylate kinase (dCMP)
product: MODEL1310110007#
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110007#

metaR RE3626M
fast: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reactant: MODEL1310110007#
reversible: false
type: Reaction
kinetic law: MODEL1310110007#
name: RE3626
modifier: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176

metaM adp c
has only substance units: false
is: CHEBI:16761
name: ADP
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB01341
is: C00008
constant: false
is: http://identifiers.org/pubchem.compound/3310
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_04b34003_b92e_461c_93b0_65de70360c67
initial concentration: NaN
is encoded by: hsa:55512
boundary condition: true
is: Q9NY59
is: SBO:0000252
type: Species
initial amount: NaN
name: SMPD3
constant: false
has only substance units: false

metaR MAL Lte
type: Reaction
product: MODEL1310110007#
fast: false
is described by: ECO:0000134
reversible: true
is: SBO:0000185
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110007#
name: Transport of L-malate

http://identifiers.org/biomodels.db/MODEL1310110007#_30dabd2a_817a_47a1_8f81_d1628f33298c
name: _AI697028_1_m
is encoded by: hsa:AI697028
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_8cebf5dd_1e5f_484d_8adb_b2316c859c78
name: SLC13A1
is: SBO:0000252
is encoded by: hsa:6561
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
is: Q9BZW2
initial amount: NaN

metaM nad r
is: SBO:0000247
initial concentration: 1.0
type: Species
name: NAD(1-)
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
is: CHEBI:57540
is: HMDB00902
constant: false

metaM but c
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: CHEBI:17968
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
type: Species
boundary condition: false
is: HMDB00039
name: butyrate

metaR DOLGPP Ler
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (liver)
reactant: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#
type: Reaction
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_15aa0b20_6b55_4f3c_b43d_49908665571d
type: Species
initial amount: NaN
initial concentration: NaN
name: GLRX2
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:51022

http://identifiers.org/biomodels.db/MODEL1310110007#_52c46114_ce7e_44e4_8cf5_4ba312c81c9e
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
name: SCD5
boundary condition: true
is: SBO:0000252
is: Q86SK9
has only substance units: false
is encoded by: hsa:79966

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

http://identifiers.org/biomodels.db/MODEL1310110007#_0f0cd256_e1b3_4bb9_b02b_40aec5702eb1
type: Species
is encoded by: hsa:3028
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q99714
name: HSD17B10

metaM lnlccoa m
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: HMDB01064
name: linoleic coenzyme A
is: http://identifiers.org/pubchem.compound/5462164

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR CYTK5n
reversible: true
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
type: Reaction
modifier: MODEL1310110007#
fast: false
name: cytidylate kinase (CMP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000269

metaR r2111
kinetic law: MODEL1310110007#
is: SBO:0000185
reactant: MODEL1310110007#
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110007#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110007#_f40faf75_fb4c_4e25_8489_f7695aa04e3d
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:9498
initial amount: NaN
boundary condition: true
type: Species
name: SLC4A8
initial concentration: NaN
is: E7EML0

http://identifiers.org/biomodels.db/MODEL1310110007#_2c130811_db18_4913_a2a9_6575cc1286b1
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: _AI694761_1_c
initial concentration: NaN
is encoded by: hsa:AI694761
type: Species
has only substance units: false

metaR CYTK4
modifier: MODEL1310110007#
type: Reaction
is: SBO:0000176
product: MODEL1310110007#
fast: false
name: cytidylate kinase (dCMP)(GTP)
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000269

metaM 10fthf c
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: C00234
boundary condition: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454
name: 10-Formyltetrahydrofolate
is: HMDB00972
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_a547d714_7bf5_42ac_abec_5f2d87d70b52
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6241
boundary condition: true
constant: false
initial amount: NaN
name: RRM2
is: P31350
has only substance units: false
type: Species

metaR r0812
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
is: SBO:0000185
kinetic law: MODEL1310110007#
reversible: true
fast: false
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.41
product: MODEL1310110007#
is described by: ECO:0000000
reactant: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85

metaM lnlncgcoa c
is: SBO:0000247
is: HMDB06368
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57363
type: Species
name: gamma-linolenoyl-CoA(4-)
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
constant: false

metaM ura e
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
type: Species
initial concentration: 1.0
is: HMDB00300
is: CHEBI:17568
boundary condition: false
name: uracil

http://identifiers.org/biomodels.db/MODEL1310110007#_db04b983_e445_4bc3_a35f_4602146b05d6
is encoded by: hsa:79695
boundary condition: true
initial concentration: NaN
type: Species
constant: false
name: GALNT12
is: SBO:0000252
initial amount: NaN
is: Q8IXK2
has only substance units: false

metaR GALSGLT1le
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-Galactose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

metaR BTNDm
is version of: http://identifiers.org/ec-code/3.5.1.12
is described by: ECO:0000269
product: MODEL1310110007#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
name: biotinidase (biotin), mitochondrial
reactant: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
reversible: false

metaR RE1845X
fast: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
product: MODEL1310110007#
name: RE1845
is: SBO:0000176
type: Reaction
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#

W3 CDTF: Thu Aug 30 18:18:43 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110007#_ae0f6dd8_aad3_4e8e_9444_7cff7ed6eb8f
boundary condition: true
name: HCST
initial amount: NaN
has only substance units: false
is: Q9UBK5
is: SBO:0000252
is encoded by: hsa:10870
type: Species
constant: false
initial concentration: NaN

metaR r2112
is described by: ECO:0000000
product: MODEL1310110007#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
reversible: true
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

metaR CHOLt4
fast: false
product: MODEL1310110007#
kinetic law: MODEL1310110007#
name: choline, sodium cotransport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
reactant: MODEL1310110007#
type: Reaction
reversible: true
is: SBO:0000185
modifier: MODEL1310110007#

metaM prostge1 c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
name: prostaglandin E1(1-)
is: HMDB01442
boundary condition: false
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: CHEBI:57397

metaR CYTK3
reversible: true
fast: false
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000269
product: MODEL1310110007#
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
name: cytidylate kinase (CMP)(GTP)

metaR C4STMO2r
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
is described by: ECO:0000000
fast: false
name: C-4 methyl sterol oxidase
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.14.13.72
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.170
reactant: MODEL1310110007#

metaM adp e
boundary condition: false
name: ADP(3-)
has only substance units: false
is: CHEBI:456216
is: SBO:0000247
is: HMDB01341
constant: false
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_d9ca7e04_e59b_4599_9ed2_35300be87da6
name: _AA021081_1_r
is encoded by: hsa:AA021081
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaM btn m
initial concentration: 1.0
has only substance units: false
is: HMDB00030
is: SBO:0000247
boundary condition: false
is: CHEBI:57586
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
initial amount: NaN
name: biotinate
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_3af9bed8_3ec6_4aac_a72b_086fe51d9b4d
boundary condition: true
is: SBO:0000297
is encoded by: hsa:2108
has only substance units: false
name: ETFA:ETFB
constant: false
has part: P13804
type: Species
is encoded by: hsa:2109
initial concentration: NaN
initial amount: NaN

metaR GACMTRc
is version of: http://identifiers.org/ec-code/2.1.1.2
kinetic law: MODEL1310110007#
reversible: true
type: Reaction
fast: false
product: MODEL1310110007#
reactant: MODEL1310110007#
name: guanidinoacetate N-methyltransferase (c)
notes: GENE_ASSOCIATION: (2593.1) or (2593.2) SUBSYSTEM: Urea cycle EC Number: 2.1.1.2 Confidence Level: 4 AUTHORS: PMID:2001229 NOTES:SAB c
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110007#

metaR 1PPDCRp
reactant: MODEL1310110007#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110007#
fast: false
reversible: false
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
name: delta1-piperideine-2-carboxylate reductase, perixosomal
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_a0b27756_21bc_4fcb_846c_95e39a257754
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q9HAS3
name: SLC28A3
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:64078
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_965a21e7_7faa_4d28_ad96_033018a8544e
initial concentration: NaN
constant: false
is: Q8TCD5
name: NT5C
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:30833
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_e8ac1ac9_3c36_42de_92d7_f6b9ec4f228d
type: Species
is: P31939
boundary condition: true
has only substance units: false
name: ATIC
is: SBO:0000252
is encoded by: hsa:471
initial amount: NaN
initial concentration: NaN
constant: false

metaR r0669
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
reversible: false
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
reactant: MODEL1310110007#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_aaeb52c0_b64a_44f0_b484_98112633bfb6
name: LDHAL6B
boundary condition: true
is: Q9BYZ2
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:92483
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_a36f6968_b7e2_4be0_9e6c_375fc14e052d
is encoded by: hsa:2530
initial amount: NaN
type: Species
name: FUT8
has only substance units: false
initial concentration: NaN
constant: false
is: B4DFS7
is: SBO:0000252
boundary condition: true

metaR AIRCr
name: phosphoribosylaminoimidazole carboxylase
reversible: true
type: Reaction
modifier: MODEL1310110007#
fast: false
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/6.3.2.6
product: MODEL1310110007#
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_28efe68b_0ec0_446a_9d06_15ec47e233b9
has only substance units: false
name: _AW299740_1_m
constant: false
boundary condition: true
type: Species
is encoded by: hsa:AW299740
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM oxa c
is: HMDB02329
constant: false
is: SBO:0000247
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial concentration: 1.0
name: oxalate(2-)
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:30623
boundary condition: false

metaR ALDD2x
reactant: MODEL1310110007#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.2.1.36
is: SBO:0000176
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
name: aldehyde dehydrogenase (acetaldehyde, NAD)
reversible: false
is described by: ECO:0000000

metaR r2113
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
product: MODEL1310110007#

metaM 10fthf e
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial amount: NaN
has only substance units: false
name: 10-formyltetrahydrofolate(2-)
is: HMDB00972
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57454

http://identifiers.org/biomodels.db/MODEL1310110007#_140f7881_a650_4239_bc55_baf6f22bfc9b
has only substance units: false
is: SBO:0000252
name: ACADSB
initial concentration: NaN
type: Species
constant: false
is: P45954
is encoded by: hsa:36
initial amount: NaN
boundary condition: true

metaR DNDPt24m
product: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000269
name: dTDP transport via dADP antiport
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
fast: false
modifier: MODEL1310110007#
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR RE1533M
reactant: MODEL1310110007#
fast: false
type: Reaction
name: RE1533
is described by: ECO:0000000
product: MODEL1310110007#
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110007#_180dacbc_f76e_4c26_b379_c18ba79e320c
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: SLC26A6
has only substance units: false
is: Q9NQU1
type: Species
constant: false
is encoded by: hsa:65010

metaR r1544
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
reactant: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110007#
product: MODEL1310110007#
fast: false

metaR FAOXC16080m
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
product: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
reversible: false
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction

metaM Rtotal2coa c
initial amount: NaN
is: HMDB00095
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:60377
constant: false
name: R total 2 coenzyme A
is: C00055
has only substance units: false
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4

metaM dcacoa m
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: Decanoyl-CoA (n-C10:0CoA)
boundary condition: false
constant: false
initial amount: NaN
is: C05274
type: Species
is: CHEBI:61430
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: HMDB06404

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_82ac7192_30c5_4464_bcb8_4eafb6a2ee79
is encoded by: hsa:53354
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is: Q8TE04
has only substance units: false
name: PANK1
initial amount: NaN

metaM creat e
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
has only substance units: false
name: creatine
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00064
is: CHEBI:16919
is: SBO:0000247
boundary condition: false

metaR UAG2EMAi
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/5.1.3.14
reversible: false
reactant: MODEL1310110007#
modifier: MODEL1310110007#
type: Reaction
name: UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
is described by: ECO:0000269
fast: false
is: SBO:0000176

metaR r1547
reactant: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
type: Reaction

metaR PEROXx
is: SBO:0000176
product: MODEL1310110007#
reversible: false
reactant: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ
name: peroxisomal lumped long chain fatty acid oxidation
kinetic law: MODEL1310110007#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR DHEAtr
is described by: ECO:0000269
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
product: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.8.2.2 Confidence Level: 1 AUTHORS: PMID:11535246,PMID:1588921 NOTES:
name: Dehydroepiandrosterone transport

metaR RE2541E
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: true
fast: false
name: RE2541
is described by: ECO:0000000
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:

metaR DESAT20 2
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
type: Reaction
kinetic law: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
reversible: false
is described by: ECO:0000000
name: fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)
product: MODEL1310110007#
modifier: MODEL1310110007#
is: SBO:0000176

metaM dgmp c
type: Species
is: CHEBI:57673
initial amount: NaN
is: C00362
is: HMDB01044
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
name: dGMP

metaR r0051
is: SBO:0000176
product: MODEL1310110007#
reversible: true
modifier: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.5
fast: false
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#

metaR PMTCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110007#
is: SBO:0000185
name: fatty acid intracellular transport
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_d56acfa6_85b4_42b4_98dd_0ce0a5ee0d73
constant: false
is encoded by: hsa:8897
name: MTMR3
is: Q13615
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_b4fccefb_e462_4bb5_abce_825d470e107f
initial amount: NaN
is: Q16836
name: HADH
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3033
is: SBO:0000252
has only substance units: false
constant: false

metaM 34hpp c
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
name: 3-(4-hydroxyphenyl)pyruvate
constant: false
is: CHEBI:36242
is: SBO:0000247
is: HMDB00707
initial amount: NaN
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179

metaR ADNt
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110007#
name: adenosine facilated transport in cytosol
kinetic law: MODEL1310110007#
is described by: ECO:0000269
product: MODEL1310110007#
is: SBO:0000185
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT

metaR FMNAT
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
type: Reaction
product: MODEL1310110007#
fast: false
name: FMN adenylyltransferase
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.2
is: SBO:0000176
reactant: MODEL1310110007#
is described by: ECO:0000134

metaM ppcoa c
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial amount: NaN
is: CHEBI:57392
initial concentration: 1.0
is: HMDB01275
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
is: C00100
name: Propanoyl-CoA
type: Species

metaM HC01409 m
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
is: CHEBI:27540
is: SBO:0000247
constant: false
initial amount: NaN
name: Hexanoyl-CoA
has only substance units: false
type: Species

metaM accoa c
is: SBO:0000247
is: CHEBI:57288
type: Species
initial amount: NaN
name: Acetyl-CoA
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: C00024
is: HMDB01206
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_b1fe7b62_997d_495f_b093_6d8d0fce35c4
is encoded by: hsa:3038
type: Species
is: O00219
is: SBO:0000252
constant: false
boundary condition: true
name: HAS3
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR PPItm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
is: SBO:0000185
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
name: diphopshate transporter, mitochondrial
fast: false
reversible: true
product: MODEL1310110007#
is described by: ECO:0000134

metaM tdchola x
boundary condition: false
name: taurochenodeoxycholate
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00951
initial concentration: 1.0
is: CHEBI:9407
type: Species
is: SBO:0000247

metaM C02470 c
is: HMDB00881
type: Species
boundary condition: false
is: C02470
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
is: http://identifiers.org/pubchem.compound/5485
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
name: Xanthurenic acid

metaM ppi c
is: CHEBI:0
constant: false
is: SBO:0000247
name: Diphosphate
notes: FORMULA: HO7P2 CHARGE: -3
initial amount: NaN
initial concentration: 1.0
is: HMDB00250
type: Species
is: C00013
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_ed75b066_3f8e_4fa4_9c6c_375cfb6003b5
initial concentration: NaN
is: Q9NVE7
has only substance units: false
boundary condition: true
name: PANK4
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:55229
initial amount: NaN

metaM fru c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
name: D-Fructose
is: HMDB00660
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: CHEBI:15824
is: C00095
constant: false

metaR HPCLx
notes: GENE_ASSOCIATION: (26062.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10468558 NOTES:pristanal is the fatty aldehyde analog of pristanic acid Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde. NJ
name: 2-hydroxyphytanoyl-CoA lyase
is described by: ECO:0000269
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaR RE2269E
fast: false
is: SBO:0000176
name: RE2269
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
is version of: http://identifiers.org/ec-code/3.4.21.39
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110007#
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#

metaR S6TASE16ly
is described by: ECO:0000000
kinetic law: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110007#
modifier: MODEL1310110007#
reversible: true
is: SBO:0000176
product: MODEL1310110007#

metaM 2mp2coa m
is: HMDB01011
constant: false
is: CHEBI:27754
initial amount: NaN
initial concentration: 1.0
name: 2-Methylprop-2-enoyl-CoA
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
is: SBO:0000247

metaR PIK3
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110007#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.154
is: SBO:0000176
modifier: MODEL1310110007#
reversible: false
fast: false
name: phosphatidylinositol 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.137
product: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.153

metaR PI45P5P
fast: false
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.36
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
type: Reaction
is: SBO:0000176
product: MODEL1310110007#
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase

metaR r1546
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true

metaR SERtN1
is described by: ECO:0000269
reversible: true
product: MODEL1310110007#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
name: Serine transport (Na, H coupled)
modifier: MODEL1310110007#
type: Reaction

metaM CE1617 r
type: Species
has only substance units: false
is: HMDB01358
is: SBO:0000247
is: CHEBI:17898
name: 9-cis-retinoate
initial concentration: 1.0
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8-,16-14+ EHMN_ABBREVIATION: CE1617
initial amount: NaN
constant: false
boundary condition: false

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

W3 CDTF: Thu Aug 30 18:18:43 BST 2012

metaM oxa e
has only substance units: false
is: HMDB02329
initial amount: NaN
constant: false
is: CHEBI:30623
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
name: oxalate(2-)

metaR AICART
type: Reaction
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000269
modifier: MODEL1310110007#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
product: MODEL1310110007#
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
is version of: http://identifiers.org/ec-code/2.1.2.3
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_eb262afa_76df_449a_ad60_7c8bba8ed52e
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:6120
name: RPE
is: Q96AT9
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252

metaR DASCBR
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
product: MODEL1310110007#
fast: false
reversible: false
modifier: MODEL1310110007#
is: SBO:0000176
reactant: MODEL1310110007#
is described by: ECO:0000269
kinetic law: MODEL1310110007#
name: dehydroascorbate reductase
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.4.1

metaR r0268
is version of: http://identifiers.org/ec-code/3.1.3.1
is version of: http://identifiers.org/ec-code/3.1.3.2
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
product: MODEL1310110007#
type: Reaction
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
reactant: MODEL1310110007#
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:

metaR r1977
kinetic law: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110007#
name: Y+LAT2 Utilized transport
is: SBO:0000185
reactant: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false

metaR PTPAT
reactant: MODEL1310110007#
is: SBO:0000176
reversible: true
product: MODEL1310110007#
name: Phosphopantetheine adenylyltransferase (EC 2.7.7.3)
is version of: http://identifiers.org/ec-code/2.7.7.3
modifier: MODEL1310110007#
is described by: ECO:0000269
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_249bd4af_b32f_47f8_a1fd_3d467623423d
name: _AI769281_1_e
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:AI769281
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false

metaR ARSA
reversible: false
modifier: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: Arylsulfatase A
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.6.8
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#

metaR 13DAMPPOX
is: SBO:0000176
fast: false
product: MODEL1310110007#
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.4.3.21
is described by: ECO:0000212
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
is version of: http://identifiers.org/ec-code/1.4.3.22
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110007#_fefaf65f_4c92_4efe_aba1_ad390751758e
is: SBO:0000297
is encoded by: hsa:55350
type: Species
boundary condition: true
constant: false
initial concentration: NaN
name: VNN3:VNN2:VNN1
has only substance units: false
initial amount: NaN
is encoded by: hsa:8875
has part: O95498

metaR RE3269C
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.48
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
name: RE3269
modifier: MODEL1310110007#
type: Reaction
is: SBO:0000176
product: MODEL1310110007#

metaR CYTK8
name: cytidylate kinase (CMP,dATP)
type: Reaction
is: SBO:0000176
product: MODEL1310110007#
reactant: MODEL1310110007#
reversible: true
kinetic law: MODEL1310110007#
fast: false
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR CYTK9
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
name: cytidylate kinase (CMP,dCTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
product: MODEL1310110007#
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110007#

metaR r1549
reactant: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110007#
fast: false
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR NDPK2n
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
fast: false
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
reactant: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
is: SBO:0000176

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaM adprib e
notes: FORMULA: C15H21N5O14P2 CHARGE: -2 INCHI: InChI=1S/C15H23N5O14P2/c16-12-7-13(18-3-17-12)20(4-19-7)14-10(23)8(21)5(32-14)1-30-35(26,27)34-36(28,29)31-2-6-9(22)11(24)15(25)33-6/h3-6,8-11,14-15,21-25H,1-2H2,(H,26,27)(H,28,29)(H2,16,17,18)/p-2/t5-,6-,8-,9-,10-,11-,14-,15?/m1/s1 EHMN_ABBREVIATION: C00301
initial concentration: 1.0
is: CHEBI:57967
is: SBO:0000247
constant: false
initial amount: NaN
name: D-ribofuranos-5-yl-ADP(2-)
boundary condition: false
has only substance units: false
type: Species
is: HMDB01178

metaR PI345P3P
is described by: ECO:0000000
is: SBO:0000176
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
reactant: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.3.67
fast: false
type: Reaction
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reversible: false

metaM dgmp e
name: dGMP(2-)
is: CHEBI:57673
initial amount: NaN
is: HMDB01044
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
type: Species
initial concentration: 1.0

metaM 34hpp e
initial concentration: 1.0
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
name: 3-(4-hydroxyphenyl)pyruvate
is: HMDB00707
type: Species
constant: false
is: SBO:0000247
is: CHEBI:36242
initial amount: NaN
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_31854bfa_8229_4bb6_8675_7e2f8c4588d0
is encoded by: hsa:80270
boundary condition: true
name: HSD3B7
has only substance units: false
initial amount: NaN
constant: false
is: Q9H2F3
is: SBO:0000252
initial concentration: NaN
type: Species

metaR r0267
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
product: MODEL1310110007#
type: Reaction
reversible: true
reactant: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.9
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
fast: false
kinetic law: MODEL1310110007#

metaM leuktrC4 e
is: CHEBI:57973
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
constant: false
is: SBO:0000247
is: HMDB01198
boundary condition: false
name: leukotriene C4(2-)
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaM CE5117 m
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
boundary condition: false
constant: false
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
initial amount: NaN
is: CHEBI:57923
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR FAOXC122m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaR RE2304E
modifier: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000176
name: RE2304
notes: GENE_ASSOCIATION: (7177.1) or (64499.1) or (23430.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.59 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
type: Reaction
reversible: true
product: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.4.21.59
kinetic law: MODEL1310110007#
fast: false

metaM nad x
has only substance units: false
boundary condition: false
is: CHEBI:57540
is: HMDB00902
name: Nicotinamide adenine dinucleotide
is: C00003
constant: false
is: http://identifiers.org/pubchem.compound/3305
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN

metaM fru e
initial concentration: 1.0
has only substance units: false
is: HMDB00660
boundary condition: false
type: Species
is: CHEBI:15824
name: D-Fructose
constant: false
is: C00095
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
initial amount: NaN
is: SBO:0000247

metaR CYTK7
name: cytidylate kinase (CMP,UTP)
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_406c13c6_c060_4d20_a07a_8eb1e1e2835e
has only substance units: false
constant: false
is encoded by: hsa:122622
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: ADSSL1
is: Q8N142
boundary condition: true

metaR r1548
fast: false
reactant: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110007#
reversible: true
type: Reaction
is: SBO:0000185

metaR PALFATPtc
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

metaR DIDPtn
kinetic law: MODEL1310110007#
fast: false
type: Reaction
name: dIDP nuclear transport
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110007#
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_3cea1992_17c8_425f_b710_4195c5047cf6
boundary condition: true
is: Q308M7
is encoded by: hsa:5169
initial amount: NaN
initial concentration: NaN
name: ENPP3
type: Species
constant: false
has only substance units: false
is: SBO:0000252

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaR IDOURtly
fast: false
kinetic law: MODEL1310110007#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#
name: iduronate transport into lysososme
type: Reaction
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
modifier: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_09163422_f6e3_4032_99fc_98faee5779ba
is encoded by: hsa:4124
type: Species
boundary condition: true
has only substance units: false
name: MAN2A1
is: SBO:0000252
initial amount: NaN
is: Q16706
constant: false
initial concentration: NaN

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR DESAT20 1
type: Reaction
reactant: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
reversible: false
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is: SBO:0000176
fast: false
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#

metaR ALAGLNexR
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
is: SBO:0000185
type: Reaction
modifier: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
name: L-alanine/glutamine reversible exchange
fast: false
reversible: true

metaR INSt
product: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
kinetic law: MODEL1310110007#
reversible: true
modifier: MODEL1310110007#
fast: false
is: SBO:0000185
name: Inosine transport (diffusion)
type: Reaction
is described by: ECO:0000269

metaM xyl D l
has only substance units: false
name: aldehydo-D-xylose
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
constant: false
is: CHEBI:15936
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR MMEm
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.1.99.1
reversible: true
modifier: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
name: methylmalonyl-CoA epimerase/racemase
fast: false
is: SBO:0000176
kinetic law: MODEL1310110007#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_11369f30_d61c_42f6_a7bb_7eab2a608406
initial concentration: NaN
constant: false
is encoded by: hsa:1962
is: SBO:0000252
name: EHHADH
has only substance units: false
is: Q9NY65
type: Species
boundary condition: true
initial amount: NaN

metaR r1903
product: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Y+LAT2 Utilized transport
fast: false
is: SBO:0000185
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reversible: false
reactant: MODEL1310110007#

metaR r2109
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110007#
reactant: MODEL1310110007#
product: MODEL1310110007#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
kinetic law: MODEL1310110007#
fast: false
is: SBO:0000185
reversible: true

metaM nrpphr e
is: HMDB00216
initial amount: NaN
constant: false
is: CHEBI:33569
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
type: Species
initial concentration: 1.0
name: Norepinephrine

http://identifiers.org/biomodels.db/MODEL1310110007#_4e3d34d4_fd7e_43c1_ab41_e1273f7c430e
is: O75874
has only substance units: false
constant: false
is encoded by: hsa:3417
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
name: IDH1

metaM glc D c
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: CHEBI:4167
is: HMDB00122
is: SBO:0000247
name: D-glucose
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species

metaM 2hb c
is: HMDB00008
is: SBO:0000247
initial concentration: 1.0
name: 2-Hydroxybutyrate
initial amount: NaN
boundary condition: false
is: CHEBI:1148
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_3d75e62e_d201_4380_bd3d_314d1f263835
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:AA977580
name: _AA977580_1_c
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaR RE2954C
is version of: http://identifiers.org/ec-code/2.7.1.40
is: SBO:0000176
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
product: MODEL1310110007#
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
modifier: MODEL1310110007#
fast: false
is described by: ECO:0000000
name: RE2954
type: Reaction

metaR C226CPT2
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110007#
name: C226 transport into the mitochondria
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110007#
modifier: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV

metaM 2hb e
is: HMDB00008
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
initial concentration: 1.0
initial amount: NaN
name: 2-Hydroxybutyrate
has only substance units: false
constant: false
type: Species
is: CHEBI:1148
boundary condition: false

metaR 4MOPte
reversible: true
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110007#
is described by: ECO:0000134
reactant: MODEL1310110007#
name: Transport of 4-methyl-2-oxopentanoate
fast: false
is: SBO:0000185
type: Reaction

metaM glyc3p c
is: C00093
initial amount: NaN
constant: false
boundary condition: false
name: Glycerol 3-phosphate
has only substance units: false
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: HMDB00126
is: CHEBI:57597
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR RE1448N
fast: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
name: RE1448
is: SBO:0000176
product: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_baee4926_1b5d_4953_91b2_91d0d18a7e05
has only substance units: false
is: Q96NR8
name: RDH12
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:145226
initial amount: NaN
constant: false

metaM ddcacoa m
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
name: Dodecanoyl-CoA (n-C12:0CoA)
is: C01832
is: CHEBI:57375
constant: false
initial amount: NaN
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: HMDB03571
is: SBO:0000247

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaR NACHEX11ly
type: Reaction
is: SBO:0000176
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110007#
product: MODEL1310110007#
fast: false
is described by: ECO:0000000
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110007#

metaR r2108
fast: false
product: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

metaM ditp c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
is: HMDB03537
is: CHEBI:61382
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
name: dITP(4-)

http://identifiers.org/biomodels.db/MODEL1310110007#_41d32837_7010_4989_8fd8_0119c0ac3cb5
is: P05164
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:4353
name: MPO
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN

metaR S3TASE2ly
fast: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
type: Reaction
reversible: true
name: N-acetylglucosamine-3-sulfatase, lysosomal
is: SBO:0000176

metaM dgsn c
initial concentration: 1.0
constant: false
is: C00330
type: Species
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: SBO:0000247
boundary condition: false
is: CHEBI:17172
name: Deoxyguanosine
initial amount: NaN
is: HMDB00085
has only substance units: false

metaR DHCR72r
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
is described by: ECO:0000269
name: 7-dehydrocholesterol reductase
modifier: MODEL1310110007#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110007#_597827ea_7d42_449a_94b4_f935edb27424
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
name: MGAT2
has only substance units: false
is encoded by: hsa:4247
boundary condition: true
is: Q10469
initial concentration: NaN

metaM CE1940 e
constant: false
name: spermidine monoaldehyde 2
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: HMDB02329
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-3-6-9-5-1-2-7-10/h7,9H,1-6,8H2/p+1 EHMN_ABBREVIATION: CE1940
is: CHEBI:30623
is: SBO:0000247

metaM HC02206 c
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:57399
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
name: prostaglandin C1(1-)
is: SBO:0000247
constant: false
boundary condition: false

metaR r0686
type: Reaction
reactant: MODEL1310110007#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
reversible: true
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.2.2

http://identifiers.org/biomodels.db/MODEL1310110007#_2a87e6e8_7448_492b_897a_0b731eb09fb7
has only substance units: false
is: B2RDZ2
type: Species
boundary condition: true
is encoded by: hsa:55312
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
name: RFK

metaM mi3p D c
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m0/s1
initial amount: NaN
name: 1D-myo-inositol 3-phosphate(2-)
is: CHEBI:58401
has only substance units: false
is: HMDB06814
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: SBO:0000247

metaM so4 c
is: HMDB01448
is: CHEBI:16189
initial concentration: 1.0
name: sulfate
constant: false
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial amount: NaN

metaM Asn X Ser Thr l
is: CHEBI:28938
notes: FORMULA: XH CHARGE: 0
is: HMDB00051
constant: false
has only substance units: false
name: protein-linked asparagine residue (N-glycosylation site)
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: C01342

metaR r0885
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is: SBO:0000185
reactant: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
fast: false
modifier: MODEL1310110007#
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.3.1.38

http://identifiers.org/biomodels.db/MODEL1310110007#_2dc4c3c7_4e4a_4bf9_a7da_85071c8b62de
is: P19801
type: Species
is: SBO:0000252
is encoded by: hsa:26
initial concentration: NaN
constant: false
boundary condition: true
name: ABP1
has only substance units: false
initial amount: NaN

metaM 6thf e
is: http://identifiers.org/pubchem.compound/169691
is: SBO:0000247
name: hexaglutamyl folate (THF)
has only substance units: false
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
initial amount: NaN

metaR r2107
is: SBO:0000185
modifier: MODEL1310110007#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110007#
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR r1837
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
reversible: false
is: SBO:0000185
type: Reaction
product: MODEL1310110007#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR LEUt5m
type: Reaction
reversible: true
name: leucine mitochondrial transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reactant: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#

metaR NH4tp
reactant: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#
type: Reaction
fast: false
kinetic law: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: ammonia peroxisomal transport

metaM nrpphr c
has only substance units: false
is: HMDB00216
is: CHEBI:33569
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
name: Norepinephrine
initial concentration: 1.0
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_641af8cf_da5b_45ec_9724_3ce96a5dc614
has only substance units: false
name: ENTPD1
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:953
constant: false
is: Q86VV3

metaM glc D e
is: CHEBI:4167
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
has only substance units: false
is: HMDB00122
initial amount: NaN
is: SBO:0000247
name: D-glucose
boundary condition: false
initial concentration: 1.0
constant: false

metaM lnlncg l
constant: false
boundary condition: false
is: HMDB03073
is: SBO:0000247
is: CHEBI:32391
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
name: gamma-linolenate
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_cd125364_76cc_4ee2_8b39_0eec9b9996f7
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10327
constant: false
boundary condition: true
name: AKR1A1
type: Species
has only substance units: false

metaR ALCD2yf
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES:NCD
fast: false
kinetic law: MODEL1310110007#
type: Reaction
reversible: false
modifier: MODEL1310110007#
is: SBO:0000176
name: alcohol dehydrogenase (ethanol, NADP), forward reaction
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110007#

metaR r0683
type: Reaction
reactant: MODEL1310110007#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
modifier: MODEL1310110007#
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110007#_de443db4_a2f8_4f51_a962_d83e9a26b756
initial concentration: NaN
is encoded by: hsa:10449
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
name: ACAA2
is: P42765
initial amount: NaN
constant: false

metaM dcholcoa r
type: Species
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:28701
is: HMDB06292
name: chenodeoxycholoyl coenzyme a
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337

http://identifiers.org/biomodels.db/MODEL1310110007#_32838ace_76ca_4db4_8f87_11546b87ab1f
is encoded by: hsa:9843
is: E9PHN8
type: Species
constant: false
boundary condition: true
initial amount: NaN
name: HEPH
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR r1904
is described by: ECO:0000000
type: Reaction
product: MODEL1310110007#
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110007#_524b50bb_cd19_4efd_b0c5_7d6db83f72d0
is encoded by: hsa:30061
boundary condition: true
name: SLC40A1
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: Q9NP59
initial amount: NaN

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaR r2106
type: Reaction
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

metaR ABUTt2r
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
is: SBO:0000185
reversible: true
is described by: ECO:0000304
product: MODEL1310110007#
fast: false
name: 4-aminobutyrate reversible transport in via proton symport
type: Reaction
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_ec6796a8_eeec_4b5b_bfbe_6656b31e2bf2
is: SBO:0000252
name: ACSL5
has only substance units: false
is encoded by: hsa:51703
is: Q9ULC5
initial amount: NaN
type: Species
constant: false
boundary condition: true
initial concentration: NaN

metaM HC02206 e
constant: false
initial amount: NaN
has only substance units: false
name: prostaglandin C1(1-)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
type: Species
is: CHEBI:57399
is: SBO:0000247

metaR RE3520E
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.11.1.9
product: MODEL1310110007#
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000176
name: RE3520

metaM glyc m
has only substance units: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: SBO:0000247
name: Glycerol
is: CHEBI:17754
is: C00116
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00131
boundary condition: false

metaR r1995
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110007#
is: SBO:0000185
type: Reaction
product: MODEL1310110007#
fast: false
modifier: MODEL1310110007#

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

metaR ARACHCPT1
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
modifier: MODEL1310110007#
reversible: false
kinetic law: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110007#
is: SBO:0000176
type: Reaction
product: MODEL1310110007#

metaR C226CPT1
product: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000176
modifier: MODEL1310110007#
name: carnitine C22:6 transferase
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_ff31fd3b_408a_44aa_9281_f27fe35fcb26
name: _W74642_1_c
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:W74642
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM C02528 c
is: HMDB00518
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
boundary condition: false
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: chenodeoxycholate
is: SBO:0000247
is: CHEBI:36234

metaM so4 e
is: SBO:0000247
type: Species
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
boundary condition: false
initial concentration: 1.0
is: HMDB01448
is: CHEBI:16189
has only substance units: false
constant: false
initial amount: NaN
name: sulfate

metaR GLACter
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:3779687 NOTES:NCD
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
name: D-glucurono-6,3-lactone transport, endoplasmic reticulum
is: SBO:0000185
product: MODEL1310110007#
reversible: true
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_cd651155_cf16_4732_804f_9b2e0aae5d0a
initial amount: NaN
is: Q53TV9
is encoded by: hsa:6120
boundary condition: true
initial concentration: NaN
name: RPE
has only substance units: false
is: SBO:0000252
type: Species
constant: false

metaR PROSTGH2t
type: Reaction
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110007#
product: MODEL1310110007#
name: Prostaglandin H2 transport
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is described by: ECO:0000269

metaM xol7ah2al c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
type: Species
is: HMDB06894
constant: false
is: CHEBI:27428
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR ASCBt4
is described by: ECO:0000269
reversible: true
name: L-ascorbate transport via proton symport
type: Reaction
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD

metaR r2105
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR FAOXC16BRx
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16br)x
type: Reaction

metaR ALDD21
reactant: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
type: Reaction
name: aldehyde dehydrogenase (pristanal, NAD)
notes: GENE_ASSOCIATION: (224.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:8528251 NOTES:NJ
product: MODEL1310110007#
is described by: ECO:0000304
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3

metaR CLPNDCOAtx
reversible: true
fast: false
kinetic law: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
is: SBO:0000185
name: fatty acid intracellular transport
reactant: MODEL1310110007#
is described by: ECO:0000000

metaR CHOLPtg
name: choline phosphate intracellular transport
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ
reactant: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_d59b9c66_1013_4f01_b57e_1bc59d1dcc8f
name: NME1
is: P15531
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:4830

metaR GALASE5ly
is: SBO:0000176
kinetic law: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is described by: ECO:0000000
reactant: MODEL1310110007#
modifier: MODEL1310110007#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaM 2dr1p c
initial amount: NaN
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
is: C00672
is: HMDB01351
boundary condition: false
type: Species
constant: false
has only substance units: false
is: CHEBI:58576
name: 2-Deoxy-D-ribose 1-phosphate
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_30102dfa_67f0_4e5f_bedf_6b46b5a44291
name: _AI935189_1_m
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:AI935189
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM pacald c
constant: false
is: HMDB06236
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:16424
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
is: SBO:0000247
type: Species
name: phenylacetaldehyde
initial amount: NaN

metaR G5SADrm
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
product: MODEL1310110007#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110007#
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
is described by: ECO:0000000
reactant: MODEL1310110007#
fast: false
reversible: true

metaM hs deg21 l
notes: FORMULA: C37H55NO38S2 CHARGE: -4
has only substance units: false
initial concentration: 1.0
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
type: Species
initial amount: NaN
constant: false
is: CHEBI:16126
boundary condition: false
is: SBO:0000247

metaR ARACHCPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
name: carnitine transferase
modifier: MODEL1310110007#
reversible: false
fast: false
kinetic law: MODEL1310110007#

metaM duri n
is: SBO:0000247
constant: false
boundary condition: false
type: Species
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: HMDB00012
name: 2'-deoxyuridine
is: CHEBI:16450
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR NH4tn
reactant: MODEL1310110007#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
is described by: ECO:0000000
name: ammonia nuclear transport
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_134fab57_ce0e_410e_99a4_0ee09c774134
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2348
name: FOLR1
has only substance units: false
initial concentration: NaN
type: Species

metaR MANter
kinetic law: MODEL1310110007#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110007#
is: SBO:0000185
fast: false
product: MODEL1310110007#
name: mannose efflux from endoplasmic reticulum

metaR r2104
type: Reaction
product: MODEL1310110007#
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110007#
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110007#_25c1fff9_071c_43fc_a05e_777c4d1ee33b
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:3613
constant: false
is: O14732
initial amount: NaN
name: IMPA2

metaM acmana r
constant: false
is: HMDB01129
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:17122
name: N-acetyl-D-mannosamine
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_656722f2_3b7f_4a42_955f_2e1137813fde
constant: false
initial concentration: NaN
is encoded by: hsa:11000
boundary condition: true
has only substance units: false
name: SLC27A3
initial amount: NaN
type: Species
is: SBO:0000252
is: Q5K4L6

http://identifiers.org/biomodels.db/MODEL1310110007#_571cfea7_8961_48b2_b561_e8b257274867
initial amount: NaN
is encoded by: hsa:48
type: Species
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: ACO1
is: P21399

http://identifiers.org/biomodels.db/MODEL1310110007#_95b7bc6d_3a02_4ab6_9ae3_42b72a6f1e10
name: SLC38A2
is encoded by: hsa:54407
is: SBO:0000252
constant: false
is: Q96QD8
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM i e
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:16382
is: HMDB12238
constant: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
type: Species
initial concentration: 1.0
name: iodide
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_71c1a813_6baf_47d5_a4e6_6993526f886d
is encoded by: hsa:11212
initial concentration: NaN
name: PROSC
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
type: Species
is: O94903

http://identifiers.org/biomodels.db/MODEL1310110007#_c92c8b91_9a88_4a92_82e3_ef03f88efa61
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is: P09417
initial amount: NaN
constant: false
name: QDPR
is encoded by: hsa:5860
boundary condition: true

metaR GASNASE3ly
type: Reaction
name: glycosylasparaginase, lysosomal
kinetic law: MODEL1310110007#
is: SBO:0000176
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.26
product: MODEL1310110007#
modifier: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_263265ae_5ce2_45b3_abb2_a9ae89b68ea5
type: Species
initial concentration: NaN
constant: false
name: SLC27A2
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: O14975
is encoded by: hsa:11001

http://identifiers.org/biomodels.db/MODEL1310110007#_7d38e38c_3b85_4118_b959_a85d71b4466e
is encoded by: hsa:64064
constant: false
is: Q9BYC2
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: OXCT2

metaR r2103
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false
product: MODEL1310110007#
reactant: MODEL1310110007#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

metaM ksii core4 deg4 l
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00812
type: Species
has only substance units: false
name: keratan sulfate II (core 4-linked), degradation product 4
initial amount: NaN
is: CHEBI:16953
notes: FORMULA: C66H108N6O48SX CHARGE: -1
initial concentration: 1.0

metaM ksi deg32 l
boundary condition: false
type: Species
is: HMDB00143
has only substance units: false
constant: false
is: CHEBI:12936
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
initial concentration: 1.0
name: keratan sulfate I, degradation product 32

metaR RE3628M
name: RE3628
reactant: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
is: SBO:0000176
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
kinetic law: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
is described by: ECO:0000000

metaR RE2079R
is described by: ECO:0000000
name: RE2079
is: SBO:0000176
product: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_ee85d93e_2155_4871_8832_318946a0246e
has only substance units: false
is encoded by: hsa:2348
boundary condition: true
name: FOLR1
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species

metaR RE3565C
fast: false
type: Reaction
reversible: true
product: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is: SBO:0000176
reactant: MODEL1310110007#
is described by: ECO:0000000
name: RE3565

metaM gluside hs c
is: CHEBI:18368
boundary condition: false
name: D-glucosyl-N-acylsphingosine
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species

metaR r2102
modifier: MODEL1310110007#
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110007#

metaR DESAT22 1p
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110007#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110007#
product: MODEL1310110007#
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)

http://identifiers.org/biomodels.db/MODEL1310110007#_65254b28_691b_48ed_81aa_dc92ecfa9419
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaM Asn X Ser Thr r
is: HMDB00051
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: XH CHARGE: 0
type: Species
is: C01342
boundary condition: false
name: protein-linked asparagine residue (N-glycosylation site)
is: CHEBI:28938
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_d11cf6ab_6132_4274_9486_7b497bc3a4af
is encoded by: hsa:50484
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: RRM2B
has only substance units: false
is: Q7LG56
initial concentration: NaN
type: Species

metaM no c
is: SBO:0000247
is: CHEBI:16480
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
is: C00533
is: HMDB03378
boundary condition: false
name: Nitric oxide
initial amount: NaN
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533

metaR DM sTn antigen g
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM sTn antigen(g)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_3ca54e9b_307c_4e1c_a00b_23002a70c9d0
initial amount: NaN
constant: false
is: SBO:0000252
is: O15121
boundary condition: true
name: DEGS1
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:8560

metaR r0688
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
kinetic law: MODEL1310110007#
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
reactant: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_fad9de7a_0e85_47a1_a487_6263ae9e2695
is encoded by: hsa:5315
is: SBO:0000252
name: PKM2
boundary condition: true
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: P14618
has only substance units: false

metaR CYSPHELAT2tc
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Cysteine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR r1831
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
fast: false
is: SBO:0000185
product: MODEL1310110007#
modifier: MODEL1310110007#
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#

metaR r1630
reversible: true
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110007#
is described by: ECO:0000000

metaR MI1PP
fast: false
is described by: ECO:0000269
reversible: false
type: Reaction
product: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.3.25
name: myo-inositol 1-phosphatase
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
modifier: MODEL1310110007#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110007#_c53e88ca_de33_4ea7_8695_113ccf8ebb56
initial amount: NaN
is encoded by: hsa:8706
has only substance units: false
is: O75752
name: B3GALNT1
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_cab29499_8ab9_4ad0_a5ec_7fb9ae69149c
boundary condition: true
name: TK2
is: O00142
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:7084
is: SBO:0000252
type: Species

metaM imp c
has only substance units: false
initial concentration: 1.0
name: IMP
boundary condition: false
is: CHEBI:58053
initial amount: NaN
type: Species
is: C00130
is: HMDB00175
constant: false
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_29360e04_abc1_458e_b78a_e837d3f72aec
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4952
initial amount: NaN
has only substance units: false
name: OCRL

metaR r0733
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.12
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110007#
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reversible: false
fast: false
product: MODEL1310110007#
is described by: ECO:0000000

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaR ORETNF
type: Reaction
is described by: ECO:0000000
product: MODEL1310110007#
reversible: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
fast: false
name: 4-oxo-retinoic acid formation (oxidation)
reactant: MODEL1310110007#

metaR MALSO3tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110007#
name: Malate:sulfite antiport, mitochondrial
fast: false
type: Reaction
reactant: MODEL1310110007#
product: MODEL1310110007#
modifier: MODEL1310110007#

metaR r0179
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
type: Reaction
reactant: MODEL1310110007#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.27
reversible: true
fast: false
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
modifier: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#

metaM thr L c
is: CHEBI:16857
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00167
is: SBO:0000247
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
type: Species
has only substance units: false
name: L-threonine
constant: false

metaR PSP L
reversible: false
reactant: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
name: phosphoserine phosphatase (L-serine)
is version of: http://identifiers.org/ec-code/3.1.3.3
is: SBO:0000176
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
product: MODEL1310110007#
modifier: MODEL1310110007#

metaR r2355
type: Reaction
is: SBO:0000185
product: MODEL1310110007#
name: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000

metaR DOLGLCP Lter
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
product: MODEL1310110007#
is: SBO:0000185
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)
reactant: MODEL1310110007#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110007#
type: Reaction
reversible: false

metaR It
modifier: MODEL1310110007#
is described by: ECO:0000269
name: Iodide uniport
product: MODEL1310110007#
is: SBO:0000185
reactant: MODEL1310110007#
type: Reaction
reversible: true
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
fast: false

metaM cyan m
is: SBO:0000247
is: HMDB02084
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: hydrogen cyanide
is: CHEBI:18407
type: Species
constant: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
boundary condition: false

metaM spmd c
name: Spermidine
boundary condition: false
constant: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: SBO:0000247
is: HMDB01257
is: CHEBI:57834
is: C00315
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0

metaR SPODMn
is described by: ECO:0000269
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
product: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
reversible: false
fast: false
name: superoxide dismutase, nuclear
kinetic law: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.15.1.1

http://identifiers.org/biomodels.db/MODEL1310110007#_f6685f54_0f0c_413d_b7b6_9580d03fd6b3
has only substance units: false
initial amount: NaN
type: Species
name: TM7SF2
is: O76062
is encoded by: hsa:7108
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false

metaR RETH
kinetic law: MODEL1310110007#
name: retinyl ester hydrolase
is described by: ECO:0000000
reversible: false
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110007#
reactant: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.1.3
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110007#_9cf9f634_ec2c_47b7_8555_6a9db5554ab8
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:10841
initial amount: NaN
initial concentration: NaN
name: FTCD
type: Species
is: SBO:0000252

metaM gar c
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
initial concentration: 1.0
name: N1-(5-Phospho-D-ribosyl)glycinamide
boundary condition: false
initial amount: NaN
is: CHEBI:58457
constant: false
is: C03838
is: HMDB02022
is: SBO:0000247
type: Species
has only substance units: false

metaM ksi deg12 l
is: HMDB00143
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:12936
is: SBO:0000247
name: keratan sulfate I, degradation product 12
initial concentration: 1.0
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_e3cca646_1a2d_49bf_ba7a_299d38e8b818
initial concentration: NaN
type: Species
is: P18283
name: GPX2
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:2877
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_2d48314c_b8cb_4cee_a2b7_77c1749c7d54
is encoded by: hsa:AI972237
has only substance units: false
initial concentration: NaN
name: _AI972237_1_c
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
boundary condition: true

metaR r0732
product: MODEL1310110007#
is described by: ECO:0000000
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is: SBO:0000176
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#

metaM thr L e
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: SBO:0000247
type: Species
is: CHEBI:16857
constant: false
boundary condition: false
has only substance units: false
name: L-threonine
is: HMDB00167

http://identifiers.org/biomodels.db/MODEL1310110007#_4bacaf5c_036d_42be_9271_2215ec453ec6
name: PPA2
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
is: F8WDN9
type: Species
is encoded by: hsa:27068
initial concentration: NaN

metaM CE2839 e
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
is: http://identifiers.org/pubchem.compound/5041
is: C01936
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
name: maltodecaose
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_e1bc28b3_ea27_40f8_845c_2b394924d6db
constant: false
type: Species
name: SLC34A2
has only substance units: false
is: SBO:0000252
is: O95436
initial amount: NaN
is encoded by: hsa:10568
boundary condition: true
initial concentration: NaN

metaR PMANM
name: phosphomannomutase
modifier: MODEL1310110007#
fast: false
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/5.4.2.2
is version of: http://identifiers.org/ec-code/5.4.2.8
type: Reaction
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:

metaM fn2m2masn g
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
is: SBO:0000247
initial amount: NaN
is: CHEBI:32984
constant: false
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine

http://identifiers.org/biomodels.db/MODEL1310110007#_491a2c53_84d6_4f42_b0f2_b64c61bb94b8
name: GALNT11
has only substance units: false
is: B3KWF4
is encoded by: hsa:63917
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaR r0178
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
product: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#
fast: false
is version of: http://identifiers.org/ec-code/2.5.1.21
modifier: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
reactant: MODEL1310110007#
is described by: ECO:0000000
reversible: true

metaM dcholcoa x
boundary condition: false
has only substance units: false
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
name: chenodeoxycholoyl coenzyme a
is: HMDB06292
is: CHEBI:28701
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial concentration: 1.0

metaR r2354
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
fast: false
type: Reaction
product: MODEL1310110007#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_4ce46b5c_e821_4915_be1c_0dd462ef5bd8
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P15328
is: SBO:0000252
name: FOLR1
is encoded by: hsa:2348
constant: false
type: Species

metaM hom L c
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
constant: false
name: L-homoserine
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00719
is: SBO:0000247
has only substance units: false
is: CHEBI:15699

metaM glyc c
is: CHEBI:17754
is: C00116
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00131
name: Glycerol
initial concentration: 1.0
boundary condition: false

metaR r1109
reversible: true
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
product: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#
fast: false
is: SBO:0000176
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
type: Reaction

metaR SPODMm
kinetic law: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.15.1.1
reversible: false
fast: false
product: MODEL1310110007#
reactant: MODEL1310110007#
name: superoxide dismutase
type: Reaction
modifier: MODEL1310110007#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)

metaR SQLEr
reversible: false
modifier: MODEL1310110007#
name: Squalene epoxidase, endoplasmic reticular (NADP)
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
product: MODEL1310110007#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.132
reactant: MODEL1310110007#
is described by: ECO:0000134
kinetic law: MODEL1310110007#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110007#_8a3bb634_12a6_4c82_81df_445a4a78c1e4
is: SBO:0000252
has only substance units: false
is: Q13232
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:4832
initial concentration: NaN
name: NME3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_7cba7050_83d2_47f1_8f9b_e506b257d640
constant: false
has only substance units: false
is: O00459
boundary condition: true
name: PIK3R2
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5296
initial amount: NaN
type: Species

metaM xol7ah2al m
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
initial concentration: 1.0
type: Species
is: HMDB06894
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:27428
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_7b7bb2db_fd79_4895_aaee_0b80bbdb8dea
is encoded by: hsa:108
initial amount: NaN
has only substance units: false
name: ADCY2
is: Q71UM8
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaR r0735
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110007#
product: MODEL1310110007#
modifier: MODEL1310110007#

metaR r2353
is described by: ECO:0000000
type: Reaction
product: MODEL1310110007#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
reversible: true
fast: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110007#

metaR H2O2tly
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
reversible: true
name: hydrogen peroxide lysosomal transport via diffusion
reactant: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110007#
fast: false

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaM spmd e
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
constant: false
boundary condition: false
is: SBO:0000247
name: Spermidine
initial concentration: 1.0
is: HMDB01257
is: CHEBI:57834
is: C00315

metaM ps hs c
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
is: CHEBI:18303
is: SBO:0000247
name: ps_hs[c]

metaM lnlncg c
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
type: Species
has only substance units: false
name: gamma-linolenate
is: CHEBI:32391
constant: false
boundary condition: false
is: HMDB03073
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR PI4PLC
is described by: ECO:0000269
kinetic law: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
fast: false
reversible: false
reactant: MODEL1310110007#
name: phosphatidylinositol 4-phosphate phospholipase C
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.4.11
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is: SBO:0000176

metaM ach n
type: Species
constant: false
name: acetylcholine
is: SBO:0000247
is: HMDB00895
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:15355
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996

metaR FAOXC2051843m
reversible: false
reactant: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
name: Beta oxidation of fatty acid
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_fca5168c_a76c_49d8_83eb_3c25090a0bc6
initial concentration: NaN
name: CDS2
is encoded by: hsa:8760
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is: O95674
initial amount: NaN

metaR r1106
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110007#
product: MODEL1310110007#
name: Postulated transport reaction
is: SBO:0000185
is described by: ECO:0000000

metaM leuktrE4 c
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: CHEBI:57462
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: leukotriene E4(1-)
type: Species
is: HMDB02200

metaR r0531
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
reversible: true
reactant: MODEL1310110007#
product: MODEL1310110007#
modifier: MODEL1310110007#
fast: false
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.34
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_b71a3907_c2b4_4c69_ba9e_9d9279755852
boundary condition: true
is: SBO:0000252
name: HEXA
constant: false
is encoded by: hsa:3073
initial concentration: NaN
type: Species
is: P06865
has only substance units: false
initial amount: NaN

metaR HACD1m
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
is: SBO:0000176
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
fast: false
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_ac2130e6_470b_41f3_8c7a_34882c75ab79
boundary condition: true
is: SBO:0000252
is encoded by: hsa:84649
type: Species
name: DGAT2
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: Q96PD7

metaR MI3PP
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
name: myo-inositol 3-phosphatase
product: MODEL1310110007#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.25
is: SBO:0000176
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_6134955a_0b5b_42dc_a967_accf0966a085
is: SBO:0000252
boundary condition: true
is encoded by: hsa:55568
has only substance units: false
initial amount: NaN
constant: false
name: GALNT10
type: Species
is: Q86SR1
initial concentration: NaN

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_3e309743_76a3_41c1_ad47_d55d73ba64e4
boundary condition: true
is: B3KVI7
is: SBO:0000252
name: IVD
constant: false
is encoded by: hsa:3712
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_a92cb137_baea_45ba_8ee7_37b5495ef2bd
is encoded by: hsa:197258
is: Q8N0W3
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
name: FUK

metaR r0734
is described by: ECO:0000000
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110007#
reversible: false

metaR PTRCOX1
reversible: false
kinetic law: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.22
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.4.3.21
name: Putrescine:oxygen oxidoreductase (deaminating)
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:9119395 NOTES:SAB
modifier: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000304
type: Reaction
fast: false

metaM i c
constant: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
type: Species
is: CHEBI:16382
boundary condition: false
is: SBO:0000247
is: HMDB12238
initial concentration: 1.0
initial amount: NaN
name: iodide
has only substance units: false

metaM orot5p c
name: Orotidine 5'-phosphate
is: HMDB00218
initial concentration: 1.0
is: C01103
is: SBO:0000247
constant: false
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
is: CHEBI:57538
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false

metaM 4nph c
boundary condition: false
name: 4-nitrophenolate
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:57917
is: HMDB01232
has only substance units: false
constant: false

metaR DHORD9
is described by: ECO:0000269
product: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.3.5.2
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
name: dihydoorotic acid dehydrogenase (quinone10)
fast: false
reversible: false

metaR r2352
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110007#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110007#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_1cd9b932_3f3a_470e_9086_530ca04b0fac
type: Species
initial concentration: NaN
name: ECHS1
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P30084
is encoded by: hsa:1892
constant: false
has only substance units: false

metaR PRISTCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
name: pristcoa peroxisomal transport
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110007#
reversible: true
kinetic law: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#

metaM glyc e
is: HMDB00131
is: CHEBI:17754
is: C00116
initial amount: NaN
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
has only substance units: false
boundary condition: false
constant: false
name: Glycerol
type: Species
initial concentration: 1.0
is: SBO:0000247

metaM tag hs e
constant: false
initial concentration: 1.0
is: CHEBI:17855
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
type: Species
has only substance units: false
name: triglyceride
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_9c5d4a5f_107c_4f0d_94ad_ce61289507e2
name: GPX6
is: SBO:0000252
is: P59796
initial concentration: NaN
is encoded by: hsa:257202
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
type: Species

metaM stcoa m
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB01114
is: C00412
name: Stearoyl-CoA (n-C18:0CoA)
is: CHEBI:57394
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
boundary condition: false

metaM imp e
has only substance units: false
is: CHEBI:58053
name: IMP(2-)
initial amount: NaN
type: Species
constant: false
is: HMDB00175
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_18e46d48_9c89_4042_acec_e3a9f9447ac3
is encoded by: hsa:H77542
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
name: _H77542_1_c
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_d8c3530f_bc33_46ce_8f26_7c5953e28fd6
initial amount: NaN
is encoded by: hsa:275
initial concentration: NaN
type: Species
has only substance units: false
has part: P23434
is encoded by: hsa:2731
is: SBO:0000297
constant: false
has part: P48728
boundary condition: true
is encoded by: hsa:2653
name: DLD:GCSH:GLDC:AMT
has part: P23378

metaM prostgh2 c
initial amount: NaN
is: CHEBI:57405
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: SBO:0000247
constant: false
is: HMDB01381
has only substance units: false
type: Species
name: prostaglandin H2(1-)

metaR MEOHtly
product: MODEL1310110007#
reactant: MODEL1310110007#
name: Methanol transporter, lysosome
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NCD

metaM man1p c
name: D-Mannose 1-phosphate
is: CHEBI:35374
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB06330

metaR FERO
fast: false
kinetic law: MODEL1310110007#
reversible: false
modifier: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
name: ferroxidase
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
product: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000134

metaR r1634
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
reversible: true
is described by: ECO:0000000

metaM dhlam m
initial amount: NaN
is: CHEBI:17694
constant: false
has only substance units: false
type: Species
is: HMDB00985
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
name: dihydrolipoamide

metaM 4abutn m
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
constant: false
is: CHEBI:58264
type: Species
is: HMDB01080
is: SBO:0000247
boundary condition: false
name: 4-ammoniobutanal
initial amount: NaN

metaR PTPATe
is described by: ECO:0000134
type: Reaction
reversible: true
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
name: PTPATe
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110007#
fast: false

metaM duri e
type: Species
constant: false
is: C00526
is: HMDB00012
is: SBO:0000247
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
boundary condition: false
has only substance units: false
name: Deoxyuridine
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16450

http://identifiers.org/biomodels.db/MODEL1310110007#_786ad192_4754_42d6_9c68_541b3bd55caa
is: SBO:0000252
constant: false
is: P19801
is encoded by: hsa:26
has only substance units: false
name: ABP1
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_90cebade_a279_44d4_9644_5c44cf6628ad
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:53354
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
name: PANK1

metaM CE0849 m
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
name: cis,cis-palmito-7,10-dienoyl-CoA
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:57795
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0

metaR KHte
kinetic law: MODEL1310110007#
type: Reaction
reversible: true
reactant: MODEL1310110007#
product: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
name: KHte
is described by: ECO:0000134

metaR r1088
fast: false
type: Reaction
product: MODEL1310110007#
name: Active transport
kinetic law: MODEL1310110007#
is described by: ECO:0000000
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
reversible: true

metaM lnlncg e
is: HMDB03073
name: gamma-linolenate
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:32391
initial amount: NaN
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
initial concentration: 1.0
has only substance units: false

metaM HC02175 c
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
name: caprate
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
initial concentration: 1.0
constant: false
is: CHEBI:27689

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaR FACOAL184
type: Reaction
product: MODEL1310110007#
reversible: true
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false
is: SBO:0000176

metaM m2mn l
type: Species
has only substance units: false
is: SBO:0000247
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
is: HMDB06537
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1

metaM CE5119 m
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
name: trans-3-cis-8-tetradecadienoyl-CoA
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:57923

metaM cholcoads x
is: SBO:0000247
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
type: Species
is: HMDB06889
has only substance units: false
is: CHEBI:27505
constant: false
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_fdc5abaf_6eb3_4085_8c41_e10c7d4fab52
initial concentration: NaN
name: TMEM54
constant: false
is encoded by: hsa:113452
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q969K7
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_3c2a4456_9682_4edf_a64a_0b8e851b650e
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:4831
initial amount: NaN
name: NME2
is: P22392
has only substance units: false

metaR r1633
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false
is described by: ECO:0000000
product: MODEL1310110007#
reversible: true
type: Reaction

metaM ksi deg28 l
initial concentration: 1.0
notes: FORMULA: C104H170N7O85S3 CHARGE: -3
type: Species
boundary condition: false
constant: false
is: SBO:0000247
name: keratan sulfate I, degradation product 28
is: CHEBI:16953
has only substance units: false
is: HMDB00812
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_02fd41a6_5401_421d_85b6_130382702e76
initial concentration: NaN
is encoded by: hsa:8140
constant: false
name: SLC7A5
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is: Q8IV97

metaR r1836
type: Reaction
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000185
modifier: MODEL1310110007#
reactant: MODEL1310110007#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
fast: false

metaR GGH 5DHFe
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (5DHF), extracellular
modifier: MODEL1310110007#
is described by: ECO:0000000
reactant: MODEL1310110007#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110007#
reversible: false
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_1e9b305c_312d_4e22_a771_0dd32fafa7ef
boundary condition: true
is encoded by: hsa:18
name: ABAT
initial amount: NaN
type: Species
is: P80404
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_7cd835b9_4b96_4b96_ba9e_c8cfa3c0a019
initial concentration: NaN
constant: false
name: _AU149534_1_c
boundary condition: true
is encoded by: hsa:AU149534
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_ef2f60f0_8343_4cdc_95d7_3af88cfd75d2
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:48
is: P21399
name: ACO1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_55f17369_41e8_4132_9092_5a5591ffff07
is encoded by: hsa:5805
name: PTS
is: SBO:0000252
is: Q03393
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_7b03ec13_118d_4bfe_bb27_5f9bf45e2b17
is: P34896
boundary condition: true
is: SBO:0000252
constant: false
name: SHMT1
is encoded by: hsa:6470
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR r2030
is described by: ECO:0000000
reactant: MODEL1310110007#
reversible: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
product: MODEL1310110007#

metaM tag hs c
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:17855
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
constant: false
has only substance units: false
initial concentration: 1.0
name: triglyceride

metaR r0954
kinetic law: MODEL1310110007#
is: SBO:0000185
type: Reaction
reversible: true
name: MCT 1 Transport reaction
product: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17180682 NOTES:
is described by: ECO:0000000

metaR DM oretn n
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: 4-oxo-retonoic acid demand
type: Reaction

metaR NADPHtru
is described by: ECO:0000000
type: Reaction
fast: false
name: NADPH transporter, endoplasmic reticulum
kinetic law: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
reversible: false
product: MODEL1310110007#
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_1e66a506_b381_44c2_b0e0_0d7fa3f75a5b
is: G5E960
has only substance units: false
initial amount: NaN
type: Species
name: PLCB3
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5331

metaR r0731
type: Reaction
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#

metaM dec47dicoa m
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: 4,7-decadienoylcoa
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
constant: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
has only substance units: false

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaR EX sarcs LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sarcosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_8a37fe5c_3e64_4af3_b2c7_d2f55ac3ad59
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:2687
name: GGT5
initial amount: NaN
boundary condition: true
is: P36269
type: Species
initial concentration: NaN

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaR ILETAm
reactant: MODEL1310110007#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.42
type: Reaction
product: MODEL1310110007#
is described by: ECO:0000269
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
name: isoleucine transaminase, mitochondrial
fast: false
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110007#_cacfef86_7acd_4c6d_bc42_67b8efecdfef
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species
name: DGKQ
is encoded by: hsa:1609
has only substance units: false
initial concentration: NaN
is: P52824

http://identifiers.org/biomodels.db/MODEL1310110007#_88dc8c1f_d378_4b87_9c7c_738b77ab4fdc
boundary condition: true
type: Species
is: P19440
is: SBO:0000252
constant: false
is encoded by: hsa:2678
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: GGT1

metaR r0321
fast: false
modifier: MODEL1310110007#
reversible: false
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
kinetic law: MODEL1310110007#
is described by: ECO:0000000
reactant: MODEL1310110007#
is: SBO:0000176
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
is version of: http://identifiers.org/ec-code/6.3.5.2
type: Reaction

metaR r1632
product: MODEL1310110007#
modifier: MODEL1310110007#
reversible: true
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaM prostgh2 e
constant: false
name: prostaglandin H2(1-)
is: HMDB01381
type: Species
has only substance units: false
is: CHEBI:57405
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaR NRPPHRtu
type: Reaction
is: SBO:0000185
reactant: MODEL1310110007#
is described by: ECO:0000269
product: MODEL1310110007#
reversible: true
fast: false
modifier: MODEL1310110007#
name: Norepinephrine uniport
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

http://identifiers.org/biomodels.db/MODEL1310110007#_096d4c9d_17ed_44a4_bb57_e994710fa12b
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is: P48728
name: AMT
initial concentration: NaN
is encoded by: hsa:275
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_5341e32f_c2af_4f1d_8f24_89aea2da3e16
name: TRNT1
boundary condition: true
is encoded by: hsa:51095
constant: false
is: Q96Q11
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM HC01162 c
type: Species
is: CHEBI:58376
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate

metaM HC02175 e
type: Species
boundary condition: false
name: caprate
has only substance units: false
constant: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
is: CHEBI:27689
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM inost c
constant: false
is: HMDB00211
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: CHEBI:17268
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: myo-inositol

metaM 5aop m
is: C00430
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
name: 5-Amino-4-oxopentanoate
is: HMDB01149
is: CHEBI:17549

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaR r0730
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
is described by: ECO:0000000
product: MODEL1310110007#
type: Reaction
is: SBO:0000176
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
reactant: MODEL1310110007#
modifier: MODEL1310110007#
reversible: false
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_5ff89414_4904_4a13_9374_86aa94ecaec2
is encoded by: hsa:93034
has only substance units: false
is: Q96P26
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
name: NT5C1B
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_55353460_e75e_48ef_8a38_ff37931449a3
has only substance units: false
is: Q9Y227
name: ENTPD4
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:9583
initial amount: NaN
initial concentration: NaN

metaM ksii core2 deg2 l
name: keratan sulfate II (core 2-linked), degradation product 2
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:12936
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
is: HMDB00143

metaM inost e
is: SBO:0000247
name: myo-inositol
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
initial amount: NaN
is: HMDB00211
initial concentration: 1.0
constant: false
is: CHEBI:17268

metaR r0680
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.137
product: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#
reversible: true
is: SBO:0000176
reactant: MODEL1310110007#

metaR EX C02528 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chenodeoxycholate exchange
type: Reaction

metaR CYSGLYexR
kinetic law: MODEL1310110007#
product: MODEL1310110007#
name: L-cysteine/glycine reversible exchanger
modifier: MODEL1310110007#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110007#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT

metaR r1631
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110007#
is: SBO:0000185
reactant: MODEL1310110007#
fast: false
product: MODEL1310110007#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110007#_bc4efc60_a627_4bac_96f5_08ad75f7d8ab
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
name: ALDH1A3
constant: false
boundary condition: true
is encoded by: hsa:220
is: P47895

metaM hom L e
is: HMDB00719
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:15699
name: L-homoserine

metaM ksi deg6 l
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00143
initial amount: NaN
is: CHEBI:12936
is: SBO:0000247
name: keratan sulfate I, degradation product 6
type: Species
has only substance units: false

metaR EX nadp LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide adenine dinucleotide phosphate exchange
type: Reaction

metaM tetde5coa x
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
name: 5-tetradecenoylcoa
type: Species
initial amount: NaN
is: HMDB03952
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: C05280
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_40fa74b8_11df_4f8d_ab89_3c4e180078e5
is encoded by: hsa:27010
is: F5GZG6
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: TPK1
initial concentration: NaN
constant: false

metaR H2Oter
name: H2O endoplasmic reticulum transport
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110007#

metaR S6TASE15ly
kinetic law: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction
reversible: true
modifier: MODEL1310110007#
product: MODEL1310110007#
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_dd6e83d5_565b_4b1e_9c41_5f0a1ecf6d70
initial concentration: NaN
constant: false
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:AA081045
name: _AA081045_1_m
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_cce691a9_5727_493b_8016_0734401e7974
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3418
name: IDH2
is: P48735
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_b3579b9a_ef55_413b_92bf_f779af078745
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5297
initial amount: NaN
name: PI4KA
is: B4DYG5
constant: false
type: Species

metaR DNDPt10m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dADP transport via dCDP antiport
is: SBO:0000185
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
fast: false
product: MODEL1310110007#
reversible: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110007#

metaM Ser Thr l
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: XH CHARGE: 0
constant: false
name: protein-linked serine or threonine residue (O-glycosylation site)
is: CHEBI:58190
is: HMDB00224

metaM val L c
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
has only substance units: false
type: Species
is: HMDB00883
initial concentration: 1.0
boundary condition: false
is: CHEBI:16414
name: L-valine
constant: false
initial amount: NaN
is: SBO:0000247

metaM cyst L c
is: HMDB00099
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C7H14N2O4S CHARGE: 0 INCHI: InChI=1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00916
boundary condition: false
constant: false
type: Species
name: L-cystathionine
initial amount: NaN
is: CHEBI:17482

metaM his L e
boundary condition: false
is: CHEBI:15971
is: HMDB00177
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
name: L-histidine
initial concentration: 1.0

metaR r0170
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.1.40
modifier: MODEL1310110007#
is: SBO:0000176
fast: false
reactant: MODEL1310110007#
product: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
type: Reaction
is described by: ECO:0000000
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21

metaR OXAtp
is described by: ECO:0000000
name: oxalate transport out of peroxisome
type: Reaction
reactant: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
product: MODEL1310110007#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110007#_b6005d64_bbf2_4991_a117_27ec32fbf3fb
is: SBO:0000297
boundary condition: true
initial amount: NaN
is encoded by: hsa:8803
constant: false
has part: E5KS60
name: SUCLG1:SUCLA2
type: Species
has only substance units: false
initial concentration: NaN

metaM hs deg19 l
is: HMDB01352
name: heparan sulfate, degradation product 19
initial amount: NaN
constant: false
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
is: CHEBI:17180
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM gluside hs r
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
name: D-glucosyl-N-acylsphingosine
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
type: Species
is: CHEBI:18368

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR r1625
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110007#
modifier: MODEL1310110007#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_57c98f2e_4a73_43e1_a8bb_8f9bb23a0d67
is: SBO:0000252
name: _AF080579_1_c
is encoded by: hsa:AF080579
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
constant: false

metaM hdca r
initial concentration: 1.0
is: C00249
is: HMDB00220
name: Hexadecanoate (n-C16:0)
has only substance units: false
initial amount: NaN
is: CHEBI:7896
constant: false
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249

http://identifiers.org/biomodels.db/MODEL1310110007#_827a9bf7_76dd_4c68_a0ce_74ae4fbf90ae
is encoded by: hsa:10610
name: ST6GALNAC2
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q9UJ37
constant: false
type: Species

metaM cyan c
is: HMDB02084
is: SBO:0000247
boundary condition: false
name: hydrogen cyanide
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: CHEBI:18407
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false

metaR NDPK7
name: nucleoside-diphosphate kinase (ATP:dCDP)
reactant: MODEL1310110007#
product: MODEL1310110007#
modifier: MODEL1310110007#
reversible: true
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false

metaM acmana e
is: HMDB01129
initial amount: NaN
is: SBO:0000247
name: N-acetyl-D-mannosamine
constant: false
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:17122

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

metaR RDH3
is: SBO:0000176
modifier: MODEL1310110007#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.315
name: retinol dehydrogenase (11-cis,NADH)
kinetic law: MODEL1310110007#
type: Reaction
fast: false
product: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
reversible: true

metaM cit e
constant: false
is: SBO:0000247
name: citrate(3-)
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: HMDB00094
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: CHEBI:16947

http://identifiers.org/biomodels.db/MODEL1310110007#_080b9f8c_aa1d_49f5_a6c7_9371c61ec6c7
is: P15291
initial concentration: NaN
boundary condition: true
name: B4GALT1
is encoded by: hsa:2683
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_1f88326f_d42c_40df_b84b_4d8e58d901b8
name: GGT2
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:728441
initial amount: NaN

metaR RE1527M
fast: false
reversible: true
reactant: MODEL1310110007#
name: RE1527
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107

metaM HC02203 e
has only substance units: false
boundary condition: false
is: CHEBI:27820
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
constant: false
name: prostaglandin-a2
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_f328a17c_e98a_4f2f_bda6_55de28f77b59
boundary condition: true
name: GGT5
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2687
is: P36269
type: Species

metaM ksii core2 deg8 l
initial amount: NaN
name: keratan sulfate II (core 2-linked), degradation product 8
is: CHEBI:12936
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
constant: false
is: HMDB00143
initial concentration: 1.0
notes: FORMULA: C36H60N3O25X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110007#_bdeae947_0146_43a5_be9d_6dbebc796c32
has only substance units: false
is encoded by: hsa:79717
is: SBO:0000252
initial concentration: NaN
name: PPCS
boundary condition: true
initial amount: NaN
constant: false
is: Q9HAB8
type: Species

metaM m8mpdol L r
is: CHEBI:59093
type: Species
notes: FORMULA: C1780H2928N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1 EHMN_ABBREVIATION: C05868
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog

metaR 4NPHte
kinetic law: MODEL1310110007#
name: xenobiotic transport
reversible: true
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110007#
type: Reaction
fast: false

metaM pi g
has only substance units: false
name: hydrogenphosphate
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
type: Species
initial concentration: 1.0
is: HMDB00973
is: SBO:0000247
is: CHEBI:43474

metaR r1626
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110007#
is: SBO:0000185

metaR LNLNCAt
product: MODEL1310110007#
type: Reaction
reversible: true
kinetic law: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
is described by: ECO:0000000

metaR MTHFC
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
kinetic law: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.5
name: methenyltetrahydrofolate cyclohydrolase
reactant: MODEL1310110007#
fast: false
product: MODEL1310110007#

metaM ach c
boundary condition: false
initial concentration: 1.0
name: acetylcholine
is: SBO:0000247
type: Species
is: CHEBI:15355
is: HMDB00895
has only substance units: false
initial amount: NaN
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
constant: false

metaM C05965 e
constant: false
type: Species
name: 12(S)-HPETE(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB04243
is: CHEBI:57444
boundary condition: false
initial concentration: 1.0

metaR NDPK8
name: Nucleoside-diphosphate kinase (ATP:dADP)
reversible: true
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
reactant: MODEL1310110007#
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_6cf72eca_485b_419d_a5af_388f20d68cec
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
name: GAMT
is: Q14353
constant: false
is encoded by: hsa:2593
type: Species

metaR r0472
fast: false
product: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
kinetic law: MODEL1310110007#
type: Reaction

metaR RDH2
modifier: MODEL1310110007#
name: retinol dehydrogenase (9-cis,NADH)
reactant: MODEL1310110007#
is described by: ECO:0000269
reversible: true
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.315
kinetic law: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110007#_1f341017_d5a7_41e8_8063_2b7ad641f087
initial amount: NaN
is encoded by: hsa:570
is: SBO:0000252
name: BAAT
boundary condition: true
is: Q14032
initial concentration: NaN
type: Species
constant: false
has only substance units: false

metaM pail45p hs n
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
name: phosphatidylinositol 4,5-bisphosphate
is: CHEBI:28910
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637

metaR H2Otly
product: MODEL1310110007#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: H2O transport, lysosomal
fast: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#

metaM HC01231 m
type: Species
is: SBO:0000247
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
name: N-[(R)-pantothenoyl]-L-cysteinate
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:58480
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_b7a48428_d448_4c1c_bb4d_78837c47b42f
name: PANK1
initial concentration: NaN
has only substance units: false
is: Q8TE04
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:53354
constant: false

metaM lald L c
initial concentration: 1.0
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
constant: false
initial amount: NaN
is: HMDB03052
is: CHEBI:18041
is: SBO:0000247
has only substance units: false
boundary condition: false
name: (S)-lactaldehyde
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_b3f3a69b_743e_4684_bffa_323e126e1551
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is: O00746
boundary condition: true
name: NME4
is encoded by: hsa:4833
type: Species

metaM his L c
name: L-histidine
constant: false
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: CHEBI:15971
initial amount: NaN
initial concentration: 1.0
is: HMDB00177

metaR FUMSO3tm
fast: false
modifier: MODEL1310110007#
type: Reaction
reversible: true
is described by: ECO:0000269
is: SBO:0000185
name: Fumarate:sulfite antiport, mitochondrial
product: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110007#

metaR GLCNACASE1ly
product: MODEL1310110007#
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
name: alpha-N-acetylglucosaminidase, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.50
modifier: MODEL1310110007#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110007#_3e91e5a1_9b88_439b_88fe_4e8559ed325c
is encoded by: hsa:2678
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: P19440
type: Species
initial concentration: NaN
has only substance units: false
name: GGT1
constant: false

metaR DM dttp m
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dTTP demand
type: Reaction

metaR r1623
fast: false
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110007#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaR RDH1
modifier: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.315
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000269
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110007#
name: retinol dehydrogenase (all-trans)
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT

metaM ps hs m
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial amount: NaN
is: CHEBI:18303
is: SBO:0000247
initial concentration: 1.0
name: ps_hs[m]
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_97ab2e83_f642_4efa_bcca_43cc8b092c68
is: SBO:0000252
initial amount: NaN
constant: false
is: Q99714
name: HSD17B10
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3028

metaR NDPK5
modifier: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110007#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
name: Nucleoside-diphosphate kinase (ATP:dGDP)
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_8000b336_6285_4af3_974e_0b99af722b2e
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: PGM2
is encoded by: hsa:55276
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: Q96G03

http://identifiers.org/biomodels.db/MODEL1310110007#_1d4af03d_8472_4330_9546_144891353331
has part: Q53XN1
is encoded by: hsa:341947
has part: P12074
constant: false
is encoded by: hsa:1329
has part: Q7Z4L0
has part: Q02221
has part: P24310
has part: H0UI06
is encoded by: hsa:170712
boundary condition: true
is encoded by: hsa:1337
initial amount: NaN
is encoded by: hsa:1345
is encoded by: hsa:9377
has part: P24311
is encoded by: hsa:9167
type: Species
has part: P09669
has part: Q53YB7
is encoded by: hsa:4514
is encoded by: hsa:4512
has part: Q7GXY8
is encoded by: hsa:1350
is encoded by: hsa:1339
has part: Q7GXZ8
is encoded by: hsa:1327
is encoded by: hsa:1349
is encoded by: hsa:84701
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: Q6YFQ2
initial concentration: NaN
has part: Q96KJ9
is encoded by: hsa:4513
has part: P13073
is encoded by: hsa:125965
has part: P00414
is encoded by: hsa:1340
has part: Q6FGA0
is: SBO:0000297
has part: P15954
is encoded by: hsa:1347
has part: P14854
has part: Q8TF08
has only substance units: false
is encoded by: hsa:1346
has part: P20674
is encoded by: hsa:1351

metaM xol7ah3 m
boundary condition: false
name: 5beta-cholestane-3alpha,7alpha,26-triol
constant: false
initial amount: NaN
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
is: CHEBI:28540
initial concentration: 1.0
has only substance units: false
is: HMDB12455
type: Species
is: SBO:0000247

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaM pail45p hs m
type: Species
name: phosphatidylinositol 4,5-bisphosphate
has only substance units: false
is: SBO:0000247
is: CHEBI:28910
initial amount: NaN
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
boundary condition: false
constant: false
initial concentration: 1.0

metaR ARAB Lt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
product: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110007#
fast: false
type: Reaction
name: L-arabinoase extracellular transport
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_2d1c35a3_80d0_4adc_bc42_bc9d98162544
type: Species
is: Q9Y5P4
initial concentration: NaN
boundary condition: true
constant: false
name: COL4A3BP
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10087
initial amount: NaN

metaM HC02203 c
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
name: prostaglandin-a2
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:27820

metaM 4hexdtricoa m
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
name: 4,7,10-hexadecatrienoylcoa
has only substance units: false
is: HMDB02288
initial concentration: 1.0
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
type: Species

metaM cholcoar x
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
has only substance units: false
is: SBO:0000247
is: CHEBI:58677
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB02178

metaM C02528 r
name: chenodeoxycholate
is: CHEBI:36234
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00518
initial concentration: 1.0
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
has only substance units: false
constant: false
type: Species

metaR PIt7
name: phosphate transport in/out via three Na+ symporter
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
is described by: ECO:0000269
fast: false
product: MODEL1310110007#
reversible: true
type: Reaction
modifier: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#

metaR O2Stx
is described by: ECO:0000000
product: MODEL1310110007#
type: Reaction
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
name: superoxide anion transport via diffusion (peroxisome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110007#_9673a273_9577_46a5_935a_e9f4365a2641
initial amount: NaN
boundary condition: true
name: SLC6A9
type: Species
is: SBO:0000252
is encoded by: hsa:6536
constant: false
initial concentration: NaN
is: B7Z3W8
has only substance units: false

metaR GLCt4
is: SBO:0000185
kinetic law: MODEL1310110007#
reversible: true
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
reactant: MODEL1310110007#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110007#
fast: false
name: glucose transport via sodium symport

http://identifiers.org/biomodels.db/MODEL1310110007#_51ea1218_bf71_4718_9f5f_b3b8e9c19d7d
constant: false
name: _AI222095_1_e
type: Species
initial concentration: NaN
is encoded by: hsa:AI222095
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaM ach e
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00895
type: Species
name: acetylcholine
is: CHEBI:15355
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996

metaR r1624
is: SBO:0000185
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM aacoa m
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: CHEBI:57286
name: acetoacetyl-CoA(4-)
is: SBO:0000247
is: HMDB01484
constant: false
has only substance units: false

metaM g6p r
is: CHEBI:61548
constant: false
type: Species
is: C00092
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: D-Glucose 6-phosphate
is: HMDB01401
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
boundary condition: false

metaR DGK1
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000269
name: deoxyguanylate kinase (dGMP:ATP)
reactant: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.8
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_eb3ccf11_0d4f_4e0a_a5e8_062d9358633f
is encoded by: hsa:8802
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: SUCLG1
is: SBO:0000252
constant: false
is: P53597
type: Species

metaR NDPK6
kinetic law: MODEL1310110007#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110007#
fast: false
name: Nucleoside-diphosphate kinase (ATP:dUDP)
is: SBO:0000176
modifier: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110007#
is described by: ECO:0000269

metaM ahcys c
initial concentration: 1.0
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: C00021
is: HMDB00939
boundary condition: false
has only substance units: false
initial amount: NaN
name: S-Adenosyl-L-homocysteine
constant: false
is: CHEBI:16680
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_03041bda_b9da_435b_9092_c9c8956b3c07
name: DGUOK
has only substance units: false
is encoded by: hsa:1716
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
is: E5KSL6
boundary condition: true
initial concentration: NaN

metaR r1292
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000185
name: Postulated transport reaction
reactant: MODEL1310110007#
fast: false
reversible: true

metaR GLCNACT L
kinetic law: MODEL1310110007#
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (liver)
reactant: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110007#
reversible: false
type: Reaction
is: SBO:0000176

metaR PIt8
is: SBO:0000185
reversible: true
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
type: Reaction
kinetic law: MODEL1310110007#
name: phosphate transport in/out via Na+ symporter
fast: false
is described by: ECO:0000006
reactant: MODEL1310110007#
modifier: MODEL1310110007#

metaM so3 c
initial concentration: 1.0
is: CHEBI:17137
type: Species
is: C00094
initial amount: NaN
name: Sulfite
is: HMDB00240
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_cfa1dbe3_ee50_4cb7_9aaa_c681e7df5cf5
has only substance units: false
name: SLC14A1
is: SBO:0000252
is encoded by: hsa:6563
constant: false
is: G0W2N5
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN

metaR r2358
is described by: ECO:0000000
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110007#
reversible: true
name: Organic anion transporter 5 Utilized transport
fast: false
is: SBO:0000185

metaR r1629
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_afc28281_96b9_4661_8db7_67703217a05b
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10317
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: Q9Y2C3
name: B3GALT5

metaM 3decdicoa m
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
name: 3,7-decadienoylcoa
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/16019966

metaM C05279 m
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: trans,cis-Lauro-2,6-dienoyl-CoA
is: SBO:0000247
is: CHEBI:28387
has only substance units: false
is: HMDB11123
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
type: Species

metaM f1a l
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: CHEBI:17151
is: HMDB02917
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: F1alpha
constant: false
type: Species
has only substance units: false

metaR RE1845C
is: SBO:0000176
type: Reaction
name: RE1845
kinetic law: MODEL1310110007#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110007#
reactant: MODEL1310110007#

metaM chol e
is: C00114
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
name: Choline
boundary condition: false
has only substance units: false
type: Species
constant: false
is: CHEBI:15354
initial concentration: 1.0
initial amount: NaN
is: HMDB00097
is: SBO:0000247

metaR r1553
reactant: MODEL1310110007#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110007#
product: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR MANt1r
product: MODEL1310110007#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110007#
name: mannose transport (uniport)
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
reactant: MODEL1310110007#
is described by: ECO:0000269
kinetic law: MODEL1310110007#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_454341d4_9efc_4bb0_b6b6_dabd226b4a8b
constant: false
initial amount: NaN
type: Species
name: MANBA
is: SBO:0000252
is: O00462
has only substance units: false
is encoded by: hsa:4126
initial concentration: NaN
boundary condition: true

metaR r1090
product: MODEL1310110007#
reversible: false
is described by: ECO:0000000
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
reactant: MODEL1310110007#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110007#
type: Reaction

metaM core6 l
is: CHEBI:12936
is: HMDB00143
name: Core 6
initial amount: NaN
notes: FORMULA: C16H27N2O10X CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
boundary condition: false
has only substance units: false

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaM 2hexdtetcoa m
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: HMDB02288
initial concentration: 1.0
initial amount: NaN
type: Species
name: 2,7,10,13-hexadecatetraenoylcoa
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false

metaM lpam m
constant: false
type: Species
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00962
is: SBO:0000247
is: CHEBI:17460
name: lipoamide
boundary condition: false

metaR r0475
type: Reaction
product: MODEL1310110007#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110007#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110007#

metaR r1291
is: SBO:0000185
fast: false
name: Postulated transport reaction
reactant: MODEL1310110007#
product: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction
kinetic law: MODEL1310110007#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_8641dae1_0317_494f_b921_344ce58b00a1
is encoded by: hsa:51196
type: Species
is: SBO:0000252
initial concentration: NaN
name: PLCE1
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: Q9P212

metaR r1552
product: MODEL1310110007#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_56a618dd_6759_437a_b4c5_ba630971da8e
boundary condition: true
constant: false
name: ACOT7
is encoded by: hsa:11332
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: O00154

http://identifiers.org/biomodels.db/MODEL1310110007#_618e3d8b_13fb_4db3_8456_ccb38b6533e2
constant: false
is: P36969
type: Species
name: GPX4
is encoded by: hsa:2879
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR r2359
kinetic law: MODEL1310110007#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110007#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110007#

metaM thcrm hs g
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:24636
name: trihexosyl ceramide
is: SBO:0000247
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
has only substance units: false

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_5413a08a_5283_4496_911c_c77198bacfdd
constant: false
boundary condition: true
is: SBO:0000252
name: ADH5
initial concentration: NaN
has only substance units: false
is: Q6IRT1
initial amount: NaN
is encoded by: hsa:128
type: Species

metaM ditp n
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
is: HMDB03537
boundary condition: false
type: Species
name: dITP(4-)
is: CHEBI:61382
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN

metaM HC02149 m
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
name: O-Propanoylcarnitine
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:28867
constant: false
initial concentration: 1.0

metaR PECGCHLe
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of pectins with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaM ddcacoa x
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:57375
name: Dodecanoyl-CoA (n-C12:0CoA)
is: C01832
constant: false
is: HMDB03571
has only substance units: false
type: Species

metaM ps hs e
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
name: phosphatidylserine
type: Species
has only substance units: false
is: CHEBI:18303
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaM hs deg5 l
is: CHEBI:17895
initial concentration: 1.0
name: heparan sulfate, degradation product 5
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00158
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
type: Species

metaR BHBtm
fast: false
is described by: ECO:0000000
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000185
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
reversible: true
type: Reaction

metaM guln c
boundary condition: false
is: HMDB03290
type: Species
is: SBO:0000247
has only substance units: false
name: L-gulonate
initial concentration: 1.0
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
constant: false
initial amount: NaN
is: CHEBI:13115

metaM mal L c
is: CHEBI:15589
constant: false
name: (S)-malate(2-)
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: SBO:0000247
is: HMDB00156
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_9ddb5b9b_dd0e_40f2_a7e1_47a972d1832a
initial concentration: NaN
is: Q15392
is encoded by: hsa:1718
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: DHCR24
boundary condition: true

metaM dha e
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:16016
is: HMDB01882
name: glycerone

metaM dcholcoa c
initial amount: NaN
has only substance units: false
is: CHEBI:28701
is: HMDB06292
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: SBO:0000247
type: Species
initial concentration: 1.0
name: chenodeoxycholoyl coenzyme a
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_6dff11d0_65f3_4aff_9838_319131b8d941
is encoded by: hsa:4702
has only substance units: false
name: NDUFA8
constant: false
is: B1AM93
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252

metaR r2356
is: SBO:0000185
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110007#
product: MODEL1310110007#
name: Organic anion transporter 5 Utilized transport
type: Reaction
reversible: true
fast: false

metaM tcynt m
initial amount: NaN
has only substance units: false
is: CHEBI:18022
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: HMDB01453
name: thiocyanate
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
constant: false

metaR r1627
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
is described by: ECO:0000000
reactant: MODEL1310110007#
reversible: true

metaM o2s x
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
has only substance units: false
name: superoxide
constant: false
type: Species
is: CHEBI:18421
boundary condition: false
is: HMDB02168
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM CE2434 m
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
is: CHEBI:57795
boundary condition: false
initial concentration: 1.0
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
constant: false

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

metaM val L e
type: Species
is: SBO:0000247
is: HMDB00883
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
has only substance units: false
is: CHEBI:16414
initial concentration: 1.0
name: L-valine
constant: false
boundary condition: false
initial amount: NaN

metaR r1551
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110007#_4498bfea_6128_4b5e_a8ae_6dd343a9882a
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5730
type: Species
name: PTGDS
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: P41222

metaR r1446
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
name: EC:1.3.3.6
product: MODEL1310110007#
is described by: ECO:0000000
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:

metaM HC01223 m
is: SBO:0000247
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57340
type: Species
constant: false
has only substance units: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
boundary condition: false

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaM ksii core4 deg3 l
is: HMDB00143
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
initial amount: NaN
is: CHEBI:12936
name: keratan sulfate II (core 4-linked), degradation product 3
boundary condition: false
initial concentration: 1.0
type: Species

metaM chol c
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
has only substance units: false
name: Choline
boundary condition: false
is: C00114
initial concentration: 1.0
type: Species
is: CHEBI:15354
is: HMDB00097
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_fcfab6df_ec45_4083_9b14_490919f540fc
is: SBO:0000252
name: LTA4H
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:4048
is: P09960
initial amount: NaN
constant: false

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR HISD
is described by: ECO:0000269
kinetic law: MODEL1310110007#
is: SBO:0000176
fast: false
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
is version of: http://identifiers.org/ec-code/4.3.1.3
reactant: MODEL1310110007#
type: Reaction
reversible: false
product: MODEL1310110007#
name: histidase

metaM fgam c
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
is: C04376
is: CHEBI:58426
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
is: SBO:0000247
type: Species
is: HMDB01308

metaM cholcoa x
type: Species
is: HMDB01374
is: CHEBI:57373
boundary condition: false
name: choloyl-CoA(4-)
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794

metaR NDPK9
reversible: true
product: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
name: nucleoside-diphosphate kinase (ATP:IDP)
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM cit c
is: SBO:0000247
is: CHEBI:16947
initial concentration: 1.0
constant: false
name: Citrate
is: HMDB00094
has only substance units: false
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: C00158
initial amount: NaN
type: Species

metaM 10fthf6glu e
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
name: 10-formyltetrahydrofolate-[Glu](6)
is: CHEBI:57454
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
is: HMDB00972

metaM acmana c
type: Species
is: SBO:0000247
is: CHEBI:17122
name: N-acetyl-D-mannosamine
initial amount: NaN
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB01129

metaM xol27oh m
is: HMDB02103
is: CHEBI:17703
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
name: 26-hydroxycholesterol
constant: false
has only substance units: false

metaM hs deg6 l
is: HMDB01352
has only substance units: false
name: heparan sulfate, degradation product 6
type: Species
is: CHEBI:17180
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN

metaR RE0688E
type: Reaction
is: SBO:0000176
product: MODEL1310110007#
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.22
reactant: MODEL1310110007#
is described by: ECO:0000000
modifier: MODEL1310110007#
name: RE0688
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
fast: false
kinetic law: MODEL1310110007#

metaR FATP3t
fast: false
name: fatty acid electroneutral transport
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is described by: ECO:0000269
type: Reaction
reversible: true

metaR S2TASE1ly
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
type: Reaction
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
name: iduronate-2-sulfatase, lysosomal
reversible: false
is: SBO:0000176
product: MODEL1310110007#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.6.13

metaR FAOXC15ATPx
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C15)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_f4b3d5c9_5d89_4dc0_b031_97e00dcb82e2
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:3945
name: LDHB
type: Species
is: P07195
initial concentration: NaN
initial amount: NaN

metaM cyan e
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: hydrogen cyanide
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: HMDB02084
is: SBO:0000247
is: CHEBI:18407
initial concentration: 1.0

metaR r0523
is described by: ECO:0000000
kinetic law: MODEL1310110007#
is: SBO:0000176
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
fast: false
modifier: MODEL1310110007#
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
product: MODEL1310110007#
reversible: false
reactant: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1

metaR MTHFD
reversible: true
fast: false
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
is: SBO:0000176
name: methylenetetrahydrofolate dehydrogenase (NADP)
is version of: http://identifiers.org/ec-code/1.5.1.5
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110007#
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_214b97b9_49a9_49ad_b91f_28744cced6e7
is: E9KL44
is encoded by: hsa:3030
name: HADHA
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true

metaM prist c
initial concentration: 1.0
constant: false
name: pristanic acid
type: Species
is: CHEBI:51340
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
initial amount: NaN
is: HMDB00795
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR GALASE7ly
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
name: beta-galactosidase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
reversible: false
modifier: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18

http://identifiers.org/biomodels.db/MODEL1310110007#_08ea3fd6_b53c_4c82_a38e_1d30834d1f74
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: _D29675_1_c
type: Species
is encoded by: hsa:D29675

metaR r1628
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
is described by: ECO:0000000
reactant: MODEL1310110007#
reversible: true
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r2357
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110007#
product: MODEL1310110007#
fast: false
type: Reaction
reversible: true
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110007#

metaR MM7B2g
type: Reaction
reversible: false
is: SBO:0000176
fast: false
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
is described by: ECO:0000000
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is version of: http://identifiers.org/ec-code/3.2.1.113

http://identifiers.org/biomodels.db/MODEL1310110007#_f8009f53_28c7_4ffc_a6b0_9a5f47941c81
has only substance units: false
is: SBO:0000252
boundary condition: true
name: _AV727634_1_c
is encoded by: hsa:AV727634
initial amount: NaN
initial concentration: NaN
type: Species
constant: false

metaM pi m
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
is: HMDB00973
is: SBO:0000247
name: hydrogenphosphate
is: C00009
boundary condition: false
constant: false
type: Species
is: CHEBI:43474
initial amount: NaN

metaR ECOAH1m
modifier: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000304
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.2.1.18
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
is: SBO:0000176
type: Reaction
product: MODEL1310110007#

metaM 2obut c
is: HMDB00005
is: CHEBI:16763
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
name: 2-Oxobutanoate
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
boundary condition: false
is: C00109

metaM fprica c
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
constant: false
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:58467
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
is: HMDB01439
initial amount: NaN
is: C04734
is: SBO:0000247

metaR DNDPt25m
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
fast: false
name: dTDP transport via dCDP antiport
reactant: MODEL1310110007#
product: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000269
kinetic law: MODEL1310110007#
type: Reaction

metaM glc D r
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
name: D-glucose
is: HMDB00122
initial concentration: 1.0
is: CHEBI:4167
is: SBO:0000247
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040

http://identifiers.org/biomodels.db/MODEL1310110007#_64787adf_2260_4755_9ad1_ec444729ecaa
has only substance units: false
is encoded by: hsa:2182
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q5JWV8
name: ACSL4
constant: false
initial amount: NaN
type: Species

metaR FAOXC12C10x
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)x
type: Reaction

metaM nm4masn g
boundary condition: false
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C54H90N3O40X CHARGE: 0
is: C05882

metaR XYLt
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
fast: false
is described by: ECO:0000269
reactant: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
name: D-xylose reversible transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110007#_127a68d3_9362_4dfb_9619_99d9dd4b01e8
is: SBO:0000252
boundary condition: true
is encoded by: hsa:NOS2A
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: _NOS2A_1_e

metaM Ser Thr g
is: CHEBI:58336
is: HMDB00645
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
initial concentration: 1.0
constant: false
is: SBO:0000247
name: protein-linked serine or threonine residue (O-glycosylation site)

metaM 5oxpro c
initial concentration: 1.0
type: Species
name: 5-oxoprolinate
is: SBO:0000247
is: CHEBI:57606
is: HMDB00267
has only substance units: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
boundary condition: false
initial amount: NaN
constant: false

metaR HDCAter
kinetic law: MODEL1310110007#
is: SBO:0000185
type: Reaction
product: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
name: palmitate ER export
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_48e600b9_afba_494f_a04d_b63ece22c808
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:276
type: Species
name: AMY1A
is: SBO:0000252
has only substance units: false
is: Q6NSB3

http://identifiers.org/biomodels.db/MODEL1310110007#_2302f4ec_1b96_4e17_9cd6_826d2143463e
name: CEPT1
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:10390
is: B3KN25
is: SBO:0000252
type: Species
constant: false

metaR UNK3
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:
name: 2-keto-4-methylthiobutyrate transamination
is described by: ECO:0000000
type: Reaction
product: MODEL1310110007#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#

metaR r0474
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: true
product: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
kinetic law: MODEL1310110007#
type: Reaction

metaR O2t
is described by: ECO:0000000
name: o2 transport (diffusion)
is: SBO:0000185
reactant: MODEL1310110007#
product: MODEL1310110007#
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
kinetic law: MODEL1310110007#

metaR LNLCCRNt
is: SBO:0000185
fast: false
reactant: MODEL1310110007#
name: transport into the mitochondria (carnitine)
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: false

metaR C4STMO2Pr
reversible: false
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
type: Reaction
modifier: MODEL1310110007#
is: SBO:0000176
name: C-4 methyl sterol oxidase
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.170
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_7f562212_6e08_4d74_8cfd_ff5fc92cc951
initial concentration: NaN
is: A0S0A7
name: NOS3
is encoded by: hsa:4846
boundary condition: true
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM mal L e
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
name: (S)-malate(2-)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00156
has only substance units: false
constant: false
is: CHEBI:15589

metaR r0317
is version of: http://identifiers.org/ec-code/1.8.1.4
product: MODEL1310110007#
type: Reaction
modifier: MODEL1310110007#
reactant: MODEL1310110007#
reversible: true
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
is version of: http://identifiers.org/ec-code/2.1.2.10
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.4.4.2
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
fast: false
kinetic law: MODEL1310110007#

metaR r0522
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
product: MODEL1310110007#
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
modifier: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000176
reversible: false

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaR FAOXC14C12x
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

metaM cit m
initial concentration: 1.0
has only substance units: false
is: CHEBI:16947
type: Species
initial amount: NaN
is: C00158
is: SBO:0000247
name: Citrate
is: HMDB00094
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
constant: false
boundary condition: false

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaM no e
is: HMDB03378
is: CHEBI:16480
initial amount: NaN
name: Nitric oxide
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
is: C00533
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
constant: false
has only substance units: false

metaR NDP7ex
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
reversible: false
name: nucleoside-diphosphatase (UDP), extracellular
is: SBO:0000176
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.6.1.6
product: MODEL1310110007#
fast: false
type: Reaction
is described by: ECO:0000269

metaM thbpt c
type: Species
constant: false
name: 5,6,7,8-tetrahydrobiopterin
is: CHEBI:15372
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
is: HMDB00027
boundary condition: false
initial concentration: 1.0

metaR r2100
reactant: MODEL1310110007#
type: Reaction
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110007#_b4e54de5_af2c_4898_aa76_2be6aa6875bb
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
name: FLAD1
constant: false
is encoded by: hsa:80308
boundary condition: true

metaR r1557
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110007#
fast: false

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_222e9872_e70e_4a38_8c09_f0f271b9551a
name: ACSL1
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P33121
is encoded by: hsa:2180
has only substance units: false
constant: false
is: SBO:0000252
type: Species

metaR NACHEX26ly
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110007#
product: MODEL1310110007#
modifier: MODEL1310110007#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110007#_8ddeb3e9_5127_46b8_a18f_eda128b35e3d
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
name: _T83654_1_e
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:T83654

metaM chito2pdol L c
has only substance units: false
type: Species
boundary condition: false
is: HMDB01196
notes: FORMULA: C1240H2028N20O170P20 CHARGE: -20 INCHI: InChI=1S/C41H72N2O17P2/c1-25(2)13-9-14-26(3)15-10-16-27(4)17-11-18-28(5)19-12-20-29(6)21-22-55-61(51,52)60-62(53,54)59-41-35(43-31(8)47)38(50)39(33(24-45)57-41)58-40-34(42-30(7)46)37(49)36(48)32(23-44)56-40/h13,15,17,19,29,32-41,44-45,48-50H,9-12,14,16,18,20-24H2,1-8H3,(H,42,46)(H,43,47)(H,51,52)(H,53,54)/b26-15+,27-17+,28-19-/t29?,32-,33-,34-,35-,36-,37-,38-,39-,40+,41-/m1/s1
initial amount: NaN
constant: false
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human liver homolog
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:12427

metaR KCC2t
type: Reaction
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
name: K+-Cl- cotransporter (NH4+)
reactant: MODEL1310110007#
is described by: ECO:0000269
product: MODEL1310110007#
reversible: true
fast: false

metaM 34dhpac c
constant: false
is: SBO:0000247
type: Species
name: 3,4-Dihydroxyphenylacetaldehyde
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043
initial amount: NaN
boundary condition: false
is: CHEBI:27978
is: HMDB03791

metaR VALTAm
product: MODEL1310110007#
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000269
reversible: true
name: valine transaminase, mitochondiral
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.6.1.42
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD

metaM 3hmbcoa m
is: CHEBI:57312
initial amount: NaN
is: HMDB01356
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
has only substance units: false
constant: false

metaR 4NPHSULT
fast: false
name: 4-Nitrophenol Sulfotransferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.1
reversible: false
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
reactant: MODEL1310110007#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#

metaM lnlncg r
is: SBO:0000247
type: Species
name: gamma-linolenate
has only substance units: false
is: HMDB03073
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
initial concentration: 1.0
is: CHEBI:32391
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_3fa6cb70_dc92_4118_ac6e_5a640b376b83
constant: false
has only substance units: false
is encoded by: hsa:5151
boundary condition: true
is: SBO:0000252
name: PDE8A
initial amount: NaN
type: Species
initial concentration: NaN
is: H0YMZ7

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

metaR 3MOPte
type: Reaction
reactant: MODEL1310110007#
reversible: true
fast: false
name: Transport of 3-methyl-2-oxopentanoate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
is described by: ECO:0000134
product: MODEL1310110007#
kinetic law: MODEL1310110007#

metaR RE1691M
modifier: MODEL1310110007#
reversible: true
reactant: MODEL1310110007#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.8.1.1
fast: false
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
product: MODEL1310110007#
name: RE1691

metaR RE3627M
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
fast: false
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
name: RE3627
type: Reaction

metaM 3dhguln c
initial amount: NaN
is: HMDB06334
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
name: 3-dehydro-L-gulonate
is: CHEBI:57655
type: Species
boundary condition: false
constant: false

metaR r2101
reactant: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110007#
reversible: true
product: MODEL1310110007#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
modifier: MODEL1310110007#

metaR RPEc
type: Reaction
kinetic law: MODEL1310110007#
fast: false
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
name: ribulose 5-phosphate 3-epimerase
reversible: true

metaR PI45P4P
name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase
product: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
type: Reaction
is: SBO:0000176

metaR r1556
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#
product: MODEL1310110007#
fast: false

metaR APOCFm
is: SBO:0000176
type: Reaction
name: Apocarboxylase formation, mitochondrial
fast: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
is described by: ECO:0000000
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_faf6bda4_07ec_4769_86da_5793915c2597
boundary condition: true
constant: false
type: Species
name: ADCY1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:107
has only substance units: false
initial concentration: NaN
is: Q08828

metaM core6 g
type: Species
name: Core 6
boundary condition: false
initial amount: NaN
has only substance units: false
is: C04383
initial concentration: 1.0
constant: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: SBO:0000247

metaR DOCO13EFATP
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: absorption or uptake of 13-docosenoic acid into cells
type: Reaction

metaM m1mpdol L c
is: CHEBI:28067
notes: FORMULA: C1360H2228N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
boundary condition: false
initial amount: NaN

metaM frdp x
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:175763
name: farnesyl pyrophosphate(3-)
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: HMDB00961
initial amount: NaN
is: SBO:0000247
type: Species
constant: false

metaM cys L c
type: Species
initial amount: NaN
is: CHEBI:17561
boundary condition: false
is: SBO:0000247
constant: false
name: L-cysteine
is: HMDB00574
has only substance units: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_80d4688a_57f0_43e5_9bdd_5151ea971bcf
is: SBO:0000297
is encoded by: hsa:6185
has only substance units: false
has part: P39656
type: Species
initial concentration: NaN
is encoded by: hsa:6184
is encoded by: hsa:1650
constant: false
boundary condition: true
has part: P04843
initial amount: NaN
has part: P04844
name: DAD1:DDOST:RPN1:RPN2
is encoded by: hsa:1603
has part: Q53G02

metaR CERT1rt
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
modifier: MODEL1310110007#
product: MODEL1310110007#
name: ceramide transport protein
is described by: ECO:0000304
fast: false
is: SBO:0000185
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: true
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide

http://identifiers.org/biomodels.db/MODEL1310110007#_90f9d0bb_7d25_4dc1_abdc_63675a0ec263
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6240
name: RRM1
is: P23921
constant: false
is: SBO:0000252

metaM hgentis c
name: homogentisate
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
type: Species
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00130
is: CHEBI:16169

metaM HC01842 c
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
initial concentration: 1.0
is: CHEBI:31997
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
type: Species
name: Phosphodimethylethanolamine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_326f90a9_e609_46e0_9ab5_48bf7f76af99
is: P20020
boundary condition: true
constant: false
type: Species
has only substance units: false
initial concentration: NaN
name: ATP2B1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:490

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaR OCCOAtx
product: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
type: Reaction
fast: false
name: fatty acid intracellular transport
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_c1268824_298f_47c6_860d_19da62d404b3
name: PLCG1
boundary condition: true
is: SBO:0000252
is: P19174
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5335
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_4cbbc25c_6e4c_4c34_b391_5d86c87dc05a
initial amount: NaN
constant: false
name: SGSH
initial concentration: NaN
is encoded by: hsa:6448
has only substance units: false
is: SBO:0000252
is: P51688
boundary condition: true
type: Species

metaR r1298
reactant: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
is described by: ECO:0000000
name: Vesicular transport
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_2c41c86c_28a7_4917_a25f_d34d565927bc
initial amount: NaN
is: Q7Z3X3
is: SBO:0000252
boundary condition: true
name: GNS
constant: false
is encoded by: hsa:2799
has only substance units: false
type: Species
initial concentration: NaN

metaM gluside hs g
is: SBO:0000247
is: CHEBI:18368
constant: false
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
name: D-glucosyl-N-acylsphingosine
initial concentration: 1.0
initial amount: NaN

metaM ahcys e
is: HMDB00939
is: CHEBI:16680
is: SBO:0000247
name: S-Adenosyl-L-homocysteine
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: C00021
constant: false
type: Species
notes: FORMULA: C14H20N6O5S CHARGE: 0
boundary condition: false

metaR r0679
product: MODEL1310110007#
fast: false
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
type: Reaction
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#

metaM CE5132 c
is: SBO:0000247
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
is: CHEBI:57923
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false

metaR r1554
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#
fast: false

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

metaR DOLPH Ler
reversible: false
name: Dolichol-phosphate phosphohydrolase, human (liver)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
reactant: MODEL1310110007#
product: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaR GLCt1r
is: SBO:0000185
product: MODEL1310110007#
type: Reaction
modifier: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
name: glucose transport (uniport)
kinetic law: MODEL1310110007#
is described by: ECO:0000269
reactant: MODEL1310110007#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_e5edb5d2_e39b_40ea_8587_0ca1885de3d5
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is: P61457
initial concentration: NaN
is encoded by: hsa:5092
constant: false
has only substance units: false
name: PCBD1

http://identifiers.org/biomodels.db/MODEL1310110007#_1da661fd_8ab5_40af_b4a1_108e97bfa136
initial concentration: NaN
is encoded by: hsa:8897
constant: false
name: MTMR3
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN

metaM gudac c
initial amount: NaN
is: HMDB00128
name: guanidinoacetic acid
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C3H7N3O2 CHARGE: 0 INCHI: InChI=1S/C3H7N3O2/c4-3(5)6-1-2(7)8/h1H2,(H,7,8)(H4,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00439 EHMN_ABBREVIATION: C00581
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:16344

metaM ru5p D c
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: CHEBI:58121
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00618
name: D-ribulose 5-phosphate(2-)
is: SBO:0000247

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaM prostgh2 r
is: SBO:0000247
has only substance units: false
name: prostaglandin H2(1-)
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
constant: false
initial amount: NaN
is: HMDB01381
boundary condition: false
is: CHEBI:57405
type: Species

metaR NACHEX13ly
product: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
is: SBO:0000176
reactant: MODEL1310110007#

metaM C02528 e
is: SBO:0000247
is: CHEBI:36234
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
name: chenodeoxycholate
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: HMDB00518
initial amount: NaN
boundary condition: false

metaM o2s n
boundary condition: false
name: superoxide
initial amount: NaN
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
constant: false
is: CHEBI:18421
type: Species
is: SBO:0000247
is: HMDB02168
has only substance units: false
initial concentration: 1.0

metaM HC00695 m
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
initial concentration: 1.0
is: CHEBI:17432
name: S-Succinyldihydrolipoamide

metaR TYMSULT
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.1
kinetic law: MODEL1310110007#
reversible: false
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
reactant: MODEL1310110007#
fast: false
is described by: ECO:0000269
product: MODEL1310110007#
name: Tyramine Sulfotransferase
type: Reaction
modifier: MODEL1310110007#

metaM HC01712 m
boundary condition: false
name: S-Glutaryldihydrolipoamide
initial amount: NaN
notes: FORMULA: C13H22NO4S2 CHARGE: -1 INCHI: InChI=1S/C13H23NO4S2/c14-11(15)5-2-1-4-10(19)8-9-20-13(18)7-3-6-12(16)17/h10,19H,1-9H2,(H2,14,15)(H,16,17) EHMN_ABBREVIATION: C06157
initial concentration: 1.0
is: CHEBI:28391
constant: false
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_2bfd1bef_6580_49ab_8ec1_95e4274ee183
name: PLCL1
initial amount: NaN
type: Species
is: Q15111
is encoded by: hsa:5334
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false

metaM cys L e
initial concentration: 1.0
is: CHEBI:17561
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00574
name: L-cysteine
type: Species
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_8c8ada9f_bed9_47ef_9f93_c39624d582ae
is encoded by: hsa:1040
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
name: CDS1
boundary condition: true
is: Q92903

http://identifiers.org/biomodels.db/MODEL1310110007#_4f31efc9_226d_423e_8b9c_6c595d608494
has only substance units: false
initial amount: NaN
is encoded by: hsa:2348
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: FOLR1

metaR FAOXC102C103m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_2c90a8ca_bfab_47bd_858f_b41d0ce9e0d7
name: _LOC728997_1_c
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:LOC728997
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true

metaR r1906
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110007#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110007#
type: Reaction
reversible: false
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#

metaM 2mpdhl m
boundary condition: false
type: Species
name: S-(2-Methylpropanoyl)-dihydrolipoamide
is: CHEBI:17577
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
is: SBO:0000247

metaM n2m2masn g
constant: false
is: C11530
notes: FORMULA: C50H83N4O35X CHARGE: 0
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)

metaR SUCCt2m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
fast: false
is: SBO:0000185
modifier: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000269
name: succinate transport, mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_eea67aab_2197_4435_be21_ca52b7d5c8b2
constant: false
is encoded by: hsa:1593
is: Q02318
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: CYP27A1
boundary condition: true
type: Species
has only substance units: false

metaM tcynt c
is: SBO:0000247
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
type: Species
initial amount: NaN
name: thiocyanate
is: CHEBI:18022
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB01453

metaR S3TASE1ly
type: Reaction
is described by: ECO:0000000
product: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
name: N-acetylglucosamine-3-sulfatase, lysosomal
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110007#
fast: false

metaR GLNS
is: SBO:0000176
name: glutamine synthetase
reversible: false
type: Reaction
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.1.1.15
reactant: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_b6bec679_058b_4e64_b5f9_95d6201da36b
is encoded by: hsa:111
initial concentration: NaN
is: O95622
initial amount: NaN
name: ADCY5
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_b07b04d3_10f4_4565_8614_c7129064ac1b
initial concentration: NaN
is: SBO:0000252
is: Q9Y673
initial amount: NaN
name: ALG5
is encoded by: hsa:29880
boundary condition: true
has only substance units: false
type: Species
constant: false

metaR HS1ly
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: false
product: MODEL1310110007#
type: Reaction
is: SBO:0000176
fast: false
name: heparan-N-sulfatase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.10.1.1

metaR FAOXC12C10m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)m
type: Reaction

metaM pi c
initial concentration: 1.0
initial amount: NaN
is: HMDB00973
is: SBO:0000247
is: CHEBI:43474
boundary condition: false
has only substance units: false
name: hydrogenphosphate
is: C00009
notes: FORMULA: HO4P CHARGE: -2
type: Species
constant: false

metaM 3otdcoa m
is: CHEBI:28726
initial concentration: 1.0
type: Species
is: HMDB03935
initial amount: NaN
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
boundary condition: false
name: 3-Oxotetradecanoyl-CoA
is: SBO:0000247
has only substance units: false
constant: false

metaM mercppyr c
initial amount: NaN
is: CHEBI:57678
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB01368
is: SBO:0000247
constant: false
name: 3-mercaptopyruvate
has only substance units: false
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957

metaM nm2masn g
is: C05884
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
initial amount: NaN
type: Species
notes: FORMULA: C42H70N3O30X CHARGE: 0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_eddc1bf3_3bb9_441f_b3ad_16c79274f3b2
type: Species
is: SBO:0000252
initial amount: NaN
is: P33121
boundary condition: true
name: ACSL1
is encoded by: hsa:2180
has only substance units: false
initial concentration: NaN
constant: false

metaR CYTK4n
fast: false
product: MODEL1310110007#
is described by: ECO:0000269
name: cytidylate kinase (dCMP,GTP),nuclear
kinetic law: MODEL1310110007#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction

metaR r1907
product: MODEL1310110007#
is described by: ECO:0000000
reactant: MODEL1310110007#
modifier: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
is: SBO:0000185
fast: false
name: Y+LAT2 Utilized transport
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR KYNAKGAT
is described by: ECO:0000269
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.6.1.64
reversible: false
product: MODEL1310110007#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.7
reactant: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
name: L-Kynurenine:2-oxoglutarate aminotransferase
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
is: SBO:0000176

metaR r1299
reactant: MODEL1310110007#
name: Vesicular transport
kinetic law: MODEL1310110007#
product: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_0b53f549_ca4a_44c5_b8b1_5a04b50ca533
boundary condition: true
initial amount: NaN
is encoded by: hsa:6520
initial concentration: NaN
name: SLC3A2
constant: false
is: P08195
type: Species
is: SBO:0000252
has only substance units: false

metaM aacoa c
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB01484
name: Acetoacetyl-CoA
constant: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: CHEBI:57286
is: C00332
boundary condition: false
type: Species
initial concentration: 1.0

metaR SUCD1m
name: succinate dehydrogenase
kinetic law: MODEL1310110007#
is: SBO:0000176
reversible: true
fast: false
reactant: MODEL1310110007#
is described by: ECO:0000134
type: Reaction
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.3.5.1
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
modifier: MODEL1310110007#

metaM 2obut m
is: SBO:0000247
name: 2-oxobutanoate
boundary condition: false
is: HMDB00005
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:16763
constant: false
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109

http://identifiers.org/biomodels.db/MODEL1310110007#_558c3bc8_2332_4466_96eb_3bcffda471ee
boundary condition: true
is: E5KNH5
is encoded by: hsa:4723
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
name: NDUFV1

metaR FAOXC123C102m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)m
type: Reaction

metaR GTHOm
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
modifier: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
reversible: false
is: SBO:0000176
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.8.1.7
kinetic law: MODEL1310110007#
fast: false
name: glutathione oxidoreductase
product: MODEL1310110007#

metaR NAHCO3 HCLt
kinetic law: MODEL1310110007#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110007#
name: bicarbonate transport (HCl/NaHCO3 exchange)
fast: false
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
reversible: true
product: MODEL1310110007#
is: SBO:0000185
modifier: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_5a1d858b_70b8_4184_b564_b00b3c340bda
type: Species
is: Q8N3T1
is: SBO:0000252
has only substance units: false
name: GALNTL2
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:117248

http://identifiers.org/biomodels.db/MODEL1310110007#_bac5d95b_5315_47a9_adaa_4e9f28c305ea
initial amount: NaN
boundary condition: true
type: Species
name: SLC22A1
has only substance units: false
constant: false
initial concentration: NaN
is: O15245
is: SBO:0000252
is encoded by: hsa:6580

http://identifiers.org/biomodels.db/MODEL1310110007#_9d24f9e7_02a9_4889_8446_27fce27eb50c
is: O14561
type: Species
is encoded by: hsa:4706
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
name: NDUFAB1
has only substance units: false

metaR SPODMx
fast: false
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.15.1.1
reactant: MODEL1310110007#
product: MODEL1310110007#
name: superoxide dismutase, peroxisome
reversible: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000269

metaM pmtcrn x
constant: false
is: HMDB00222
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
name: L-palmitoylcarnitine
has only substance units: false
initial concentration: 1.0
is: CHEBI:17490

http://identifiers.org/biomodels.db/MODEL1310110007#_df9f8ff5_5574_4f3b_be67_d86bb1884edf
initial amount: NaN
constant: false
name: DGKE
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8526
is: A1L4Q0

http://identifiers.org/biomodels.db/MODEL1310110007#_5393b604_1b7c_427c_a38d_32a7a20292fd
boundary condition: true
initial concentration: NaN
constant: false
type: Species
has only substance units: false
name: _AA177072_1_c
initial amount: NaN
is encoded by: hsa:AA177072
is: SBO:0000252

metaM mal L m
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00156
name: (S)-malate(2-)
is: CHEBI:15589
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR NACASPAH
notes: GENE_ASSOCIATION: (443.1) or (91703.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.15 Confidence Level: 4 AUTHORS: PMID:8252036 NOTES:SAB
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.15
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
name: N-Acetyl-L-aspartate amidohydrolase
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110007#
reactant: MODEL1310110007#
reversible: false
fast: false

metaM dhcholestanate x
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00359
has only substance units: false
is: CHEBI:16577
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate

metaR PEAMNO
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110007#
is described by: ECO:0000304
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.4.3.4
fast: false
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.4.3.21
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
product: MODEL1310110007#
name: Phenethylamine oxidase

metaM tcynt e
constant: false
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: HMDB01453
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: thiocyanate
initial concentration: 1.0
type: Species
is: CHEBI:18022

metaR r1559
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#
fast: false

metaM val L m
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: L-valine
initial amount: NaN
constant: false
type: Species
is: CHEBI:16414
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: HMDB00883

metaR NDPK3n
reactant: MODEL1310110007#
product: MODEL1310110007#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110007#
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
is described by: ECO:0000304
modifier: MODEL1310110007#
reversible: true

metaR DUMPtn
is described by: ECO:0000000
reactant: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: dUMP nuclear transport
reversible: true
kinetic law: MODEL1310110007#
fast: false

metaR r0801
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000185
modifier: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
fast: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:

metaM HC02149 c
name: O-Propanoylcarnitine
type: Species
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: CHEBI:28867
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR ACACT1r
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.9
is described by: ECO:0000000
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
product: MODEL1310110007#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110007#
name: acetyl-CoA C-acetyltransferase
reactant: MODEL1310110007#
reversible: true

metaR FAOXC143C123m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

metaR UMPK3n
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (UTP),nuclear
product: MODEL1310110007#
is: SBO:0000176
reactant: MODEL1310110007#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110007#
fast: false
reversible: true
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR MEOHt2
is: SBO:0000185
product: MODEL1310110007#
reversible: true
type: Reaction
name: Methanol diffusion
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110007#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_1f462681_a410_4268_945b_1d297c131f8d
initial amount: NaN
is: Q93099
type: Species
initial concentration: NaN
is encoded by: hsa:3081
constant: false
name: HGD
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaM pi e
is: CHEBI:43474
initial concentration: 1.0
boundary condition: false
name: hydrogenphosphate
has only substance units: false
is: C00009
constant: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN
is: HMDB00973
is: SBO:0000247
type: Species

metaR r1909
reversible: false
type: Reaction
product: MODEL1310110007#
modifier: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_7b3bf29d_3b0f_4f68_96d2_f55cd541ff4d
is encoded by: hsa:5051
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q99487
is: SBO:0000252
name: PAFAH2

metaR EX adp
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adp exchange
type: Reaction

metaM zymst r
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: zymosterol
constant: false
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
is: HMDB06271
type: Species
is: CHEBI:18252
boundary condition: false

metaR NACHEX16ly
type: Reaction
is: SBO:0000176
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
modifier: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false

metaR RE1534M
reactant: MODEL1310110007#
fast: false
name: RE1534
is described by: ECO:0000000
type: Reaction
product: MODEL1310110007#
reversible: true
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

metaM hs deg13 l
initial amount: NaN
initial concentration: 1.0
name: heparan sulfate, degradation product 13
boundary condition: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
is: HMDB01352
is: CHEBI:17180
has only substance units: false

metaR PPCDC
is version of: http://identifiers.org/ec-code/4.1.1.36
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
reactant: MODEL1310110007#
name: phosphopantothenoylcysteine decarboxylase
product: MODEL1310110007#
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110007#

metaR NDPK3m
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
reactant: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
is described by: ECO:0000254
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110007#
fast: false
modifier: MODEL1310110007#

metaR SBTR
modifier: MODEL1310110007#
name: D-sorbitol reductase
type: Reaction
reactant: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.21
product: MODEL1310110007#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2
reversible: false
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
kinetic law: MODEL1310110007#

metaR PROSTGF2t
product: MODEL1310110007#
name: prostaglandin uniport
fast: false
reactant: MODEL1310110007#
modifier: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110007#

metaM glysar e
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/93131
type: Species
notes: FORMULA: C5H10N2O3 CHARGE: 0
boundary condition: false
name: Glycylsarcosine
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR r0651
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
product: MODEL1310110007#
reversible: true

metaM hs deg8 l
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
constant: false
is: CHEBI:16126
type: Species
has only substance units: false
name: heparan sulfate, degradation product 8

http://identifiers.org/biomodels.db/MODEL1310110007#_ad2901e5_983b_48a1_9fac_2390b0873fc7
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:4713
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
is: P17568
name: NDUFB7

metaM hexde7coa x
type: Species
has only substance units: false
is: SBO:0000247
name: 7-hexadecenoylcoa
constant: false
initial amount: NaN
is: HMDB02288
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4

metaM 5mthf c
type: Species
constant: false
is: SBO:0000247
is: HMDB01396
boundary condition: false
is: CHEBI:3729
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: C00440
name: 5-Methyltetrahydrofolate
initial amount: NaN

metaM pchol hs c
initial concentration: 1.0
has only substance units: false
is: CHEBI:16110
boundary condition: false
type: Species
initial amount: NaN
name: Phosphatidylcholine
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
is: SBO:0000247

metaR r1660
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
is: SBO:0000185
reversible: true
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

W3 CDTF: Thu Aug 30 18:18:44 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110007#_eded0f43_fa90_45aa_a280_09b4945c59ec
is: P35354
constant: false
boundary condition: true
name: PTGS2
has only substance units: false
is encoded by: hsa:5743
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_dd407dfb_9ba4_4ac6_99d3_6de778cd6287
is encoded by: hsa:51022
name: GLRX2
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is: Q9NS18

metaR r0652
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
product: MODEL1310110007#
reversible: true
modifier: MODEL1310110007#
fast: false
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_ef544fe8_404d_4539_acff_bf7962612277
is: O75907
is: SBO:0000252
is encoded by: hsa:8694
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: DGAT1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_5010fa30_572a_448c_b2f0_2de8440314b0
is encoded by: hsa:6565
initial concentration: NaN
type: Species
has only substance units: false
constant: false
boundary condition: true
name: SLC15A2
initial amount: NaN
is: Q16348
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_dd09fe2f_f0e5_483d_9e5c_3853b0426672
constant: false
is: Q9H0P0
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:51251
initial concentration: NaN
name: NT5C3
is: SBO:0000252

metaM udp r
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
has only substance units: false
is: CHEBI:58223
is: HMDB00295
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C00015
boundary condition: false
type: Species
name: UDP

http://identifiers.org/biomodels.db/MODEL1310110007#_31c1c5b0_7596_4169_b02d_dd5a0475c465
is encoded by: hsa:6389
type: Species
has only substance units: false
name: SDHA
is: P31040
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM cmpacna g
boundary condition: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:57812
initial amount: NaN
type: Species
is: HMDB01176
name: CMP-N-acetyl-beta-neuraminate(2-)
constant: false

metaR 2HBO
modifier: MODEL1310110007#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.27
product: MODEL1310110007#
is: SBO:0000176
reversible: true
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
type: Reaction

metaM adn e
initial amount: NaN
is: SBO:0000247
name: Adenosine
initial concentration: 1.0
has only substance units: false
is: HMDB00050
type: Species
is: C00212
is: CHEBI:16335
constant: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_7b50d792_6383_41f0_b3d9_49a5aca2d1c1
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:30
name: ACAA1
constant: false
is: Q96CA6
has only substance units: false
type: Species
initial concentration: NaN

metaM HC01408 m
is: SBO:0000247
name: 3-Oxohexanoyl-CoA
is: CHEBI:27648
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_ac8415d1_8e96_46ef_af42_1a964d90054c
is: SBO:0000252
is: Q16795
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
is encoded by: hsa:4704
initial concentration: NaN
name: NDUFA9

metaR DCSPTN1CRNt
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
name: transport into the mitochondria (carnitine)
reversible: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
modifier: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#

metaM dmpp x
boundary condition: false
constant: false
name: prenyl diphosphate(3-)
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
is: CHEBI:57623
is: HMDB01120

http://identifiers.org/biomodels.db/MODEL1310110007#_a7ec3956_f3fe_4044_9718_4b1342b86c06
is encoded by: hsa:55350
is: SBO:0000252
name: VNN3
initial concentration: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_15d27e20_8979_440b_b076_a60b721777c5
has only substance units: false
name: ETFDH
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2110
is: Q16134
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_cffcf997_ea55_427b_84b1_6682b6ff815e
boundary condition: true
is encoded by: hsa:2954
type: Species
is: SBO:0000252
initial concentration: NaN
name: GSTZ1
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_4d76bbcc_e473_4635_a5e1_44d79702c586
type: Species
has only substance units: false
is encoded by: hsa:5238
constant: false
name: PGM3
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: B4DX94
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_1d7e3a96_ad6b_4218_8b49_34f13f8144e3
is: SBO:0000252
name: ACADM
is: P11310
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:34

metaR r1806
product: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110007#
reversible: false
type: Reaction
reactant: MODEL1310110007#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_c1f797bc_530c_4af4_8fc5_2b72906d9309
initial amount: NaN
has only substance units: false
type: Species
is: Q9Y5L3
is encoded by: hsa:954
name: ENTPD2
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_809fc59e_810b_457f_821b_00e66e8927f1
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:126328
is: SBO:0000252
name: NDUFA11
is: C9JT23
has only substance units: false
constant: false

metaM 5mthf e
type: Species
is: HMDB01396
is: CHEBI:3729
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: C00440
notes: FORMULA: C20H24N7O6 CHARGE: -1
initial amount: NaN
name: 5-Methyltetrahydrofolate
constant: false
is: SBO:0000247

metaM glysar c
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/93131
constant: false
name: Glycylsarcosine
has only substance units: false
notes: FORMULA: C5H10N2O3 CHARGE: 0
initial concentration: 1.0

metaM arg L m
is: CHEBI:32682
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: HMDB00517
initial amount: NaN
initial concentration: 1.0
name: L-argininium(1+)
has only substance units: false
constant: false

metaR r0653
is: SBO:0000176
is described by: ECO:0000000
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
product: MODEL1310110007#

metaR RE3566C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
product: MODEL1310110007#
reversible: true
kinetic law: MODEL1310110007#
type: Reaction
is: SBO:0000176
fast: false
name: RE3566
reactant: MODEL1310110007#

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaR BAAT2x
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110007#
fast: false
type: Reaction
product: MODEL1310110007#
name: bile acid Coenzyme A: amino acid N-acyltransferase
modifier: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000269

metaR GCHOLAte
is described by: ECO:0000000
product: MODEL1310110007#
is: SBO:0000185
reactant: MODEL1310110007#
name: bile acid intracellular transport
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

metaR NTD6
reactant: MODEL1310110007#
modifier: MODEL1310110007#
product: MODEL1310110007#
reversible: false
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
type: Reaction
kinetic law: MODEL1310110007#
is: SBO:0000176
fast: false
name: 5'-nucleotidase (dAMP)
is version of: http://identifiers.org/ec-code/3.1.3.5
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110007#_23a133de_3d4a_4c7f_8c52_04cbbc03ebad
type: Species
initial amount: NaN
name: BCKDHB
is: SBO:0000252
constant: false
initial concentration: NaN
is: P21953
has only substance units: false
boundary condition: true
is encoded by: hsa:594

http://identifiers.org/biomodels.db/MODEL1310110007#_98f55b1c_a9dc_44cd_a25f_365557bc6f04
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI435857
type: Species
initial amount: NaN
initial concentration: NaN
name: _AI435857_1_x
has only substance units: false

metaR r1662
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110007#
modifier: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
type: Reaction

metaM dec24dicoa m
has only substance units: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
is: HMDB01168
boundary condition: false
name: 2,4-decadienoylcoa

metaR HSPASEly
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110007#
name: heparan sulfate proteoglycan protease, lysosome (endosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
type: Reaction
kinetic law: MODEL1310110007#
reversible: false
fast: false
reactant: MODEL1310110007#

metaM xol7a r
initial concentration: 1.0
is: CHEBI:1296
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
has only substance units: false
is: HMDB01496
name: 20-hydroxycholesterol

http://identifiers.org/biomodels.db/MODEL1310110007#_1b0a6a02_c2f4_4383_8ea9_1099e195f990
type: Species
is: P40926
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4191
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
name: MDH2

http://identifiers.org/biomodels.db/MODEL1310110007#_a4630e19_0ba0_49bc_8e9a_a7f5fb59b319
initial concentration: NaN
has only substance units: false
is: O75356
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:957
constant: false
name: ENTPD5
is: SBO:0000252

metaM hcys L c
is: CHEBI:17588
constant: false
has only substance units: false
name: L-homocysteine
is: HMDB00742
boundary condition: false
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaM 3pg m
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58272
boundary condition: false
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
type: Species
has only substance units: false
is: HMDB00807
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
initial amount: NaN
constant: false

metaM man l
is: HMDB00169
is: CHEBI:16024
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false
boundary condition: false
is: SBO:0000247
name: D-mannose

http://identifiers.org/biomodels.db/MODEL1310110007#_22ade81a_14b5_4702_a2d3_7023fb02f295
has only substance units: false
boundary condition: true
is encoded by: hsa:109
is: B3KT86
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
name: ADCY3
type: Species

metaR ACt2m
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
is: SBO:0000185
type: Reaction
reactant: MODEL1310110007#
is described by: ECO:0000000
fast: false
name: acetate mitochondrial transport via proton symport
reversible: true
kinetic law: MODEL1310110007#
product: MODEL1310110007#

metaR r1661
kinetic law: MODEL1310110007#
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_f7268024_6b3b_46b8_960d_e55d38ea27a2
is: SBO:0000252
is: Q8N695
constant: false
type: Species
has only substance units: false
is encoded by: hsa:160728
name: SLC5A8
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_a335398d_6e98_49f3_9887_8b241afd14cc
has part: P08195
initial concentration: NaN
is: SBO:0000297
name: SLC7A10:SLC3A2
has only substance units: false
type: Species
has part: Q9NS82
initial amount: NaN
is encoded by: hsa:56301
boundary condition: true
is encoded by: hsa:6520
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_a5f23df9_9515_4dd9_ac56_8621c2c440cd
has only substance units: false
name: _642502_1_c
type: Species
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:642502
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_7da631f2_396b_4a69_aeb9_bb8b2b9c1b4d
name: RHBG
is: SBO:0000252
is encoded by: hsa:57127
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q9H310
constant: false
has only substance units: false
type: Species

metaM CE5854 e
has only substance units: false
is: SBO:0000247
is: HMDB02710
is: CHEBI:27485
name: gama-CEHC-glucuronide
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_7070bcfe_146c_401a_88fc_0957ce070dda
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI091231
name: _AI091231_1_c
constant: false
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_861b3ca5_c9e6_4c70_8132_70154488cc03
name: DPM2
constant: false
has only substance units: false
initial concentration: NaN
is: O94777
is encoded by: hsa:8818
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM ppa c
boundary condition: false
type: Species
is: CHEBI:17272
is: SBO:0000247
initial concentration: 1.0
name: propionate
constant: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
has only substance units: false
is: HMDB00237
initial amount: NaN

metaR r0033
modifier: MODEL1310110007#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110007#
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
reversible: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110007#
reactant: MODEL1310110007#

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaR ACACT1rm
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: true
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
product: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110007#
name: acetyl-CoA C-acetyltransferase, mitochondrial
is: SBO:0000176
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_bab65cda_2add_41b9_983e_ab9d4b2fd194
constant: false
boundary condition: true
is: SBO:0000252
type: Species
name: _BE966236_1_m
is encoded by: hsa:BE966236
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM ksii core4 l
initial concentration: 1.0
constant: false
is: CHEBI:57255
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
name: keratan sulfate II (core 4-linked)
is: HMDB01014
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false

metaM o2s m
name: Superoxide anion
constant: false
is: C00704
has only substance units: false
is: SBO:0000247
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial concentration: 1.0
is: CHEBI:18421
initial amount: NaN
type: Species
is: HMDB02168
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_11b4ad48_c48a_447b_9c7f_fd2fce939733
name: ATP2B4
type: Species
boundary condition: true
is: P23634
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:493
has only substance units: false

metaR r0281
type: Reaction
is: SBO:0000176
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/5.3.1.6
reversible: true
reactant: MODEL1310110007#
product: MODEL1310110007#
fast: false
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
is described by: ECO:0000000

metaR G6Pter
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
product: MODEL1310110007#
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110007#
fast: false
is described by: ECO:0000269
reversible: true
type: Reaction
kinetic law: MODEL1310110007#

metaM xylu L c
initial amount: NaN
type: Species
constant: false
is: CHEBI:17399
has only substance units: false
name: L-xylulose
is: HMDB00751
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
initial concentration: 1.0

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_4fb18a1b_210b_4e9b_98a9_63b93e9bc30e
constant: false
is: A0PJJ9
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:2686
is: SBO:0000252
initial concentration: NaN
name: GGT7

metaM dolglcp L c
constant: false
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:15812
has only substance units: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
initial concentration: 1.0

metaR FAEL183
product: MODEL1310110007#
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
name: fatty-acyl-CoA elongation (n-C18:3CoA)
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110007#

metaR NH4t3r
name: ammonia transport via proton antiport
is: SBO:0000185
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
product: MODEL1310110007#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110007#
reversible: true
fast: false
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#

metaM e4hglu m
initial concentration: 1.0
is: HMDB02273
is: CHEBI:6331
type: Species
constant: false
boundary condition: false
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
name: erythro-4-hydroxy-L-glutamate(1-)
has only substance units: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_1f633f22_8c6b_4bcd_8c2f_59db33776478
is: P07203
constant: false
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
name: GPX1
is encoded by: hsa:2876
is: SBO:0000252
initial concentration: NaN

metaM pap c
is: HMDB00061
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: adenosine 3',5'-bismonophosphate(4-)
is: CHEBI:58343
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
type: Species
initial amount: NaN
boundary condition: false
constant: false

metaR ORETNtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
product: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
type: Reaction
is: SBO:0000185
name: 4-oxo-retinoic acid transport, Nuclear
reversible: true
kinetic law: MODEL1310110007#

metaM 5dhf e
type: Species
initial concentration: 1.0
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
is: HMDB06487
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
name: pentaglutamyl folate (DHF)

metaM dcsptn1coa c
is: HMDB06513
is: http://identifiers.org/pubchem.compound/47205483
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: C16173
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: SBO:0000247
type: Species
boundary condition: false

metaR NACHEX20ly
modifier: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110007#
type: Reaction

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_bebfc310_7c8a_4def_bdbf_3600edbd462b
is: SBO:0000252
is: Q9BX95
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:81537
name: SGPP1
has only substance units: false
constant: false

metaR HSAT1ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
product: MODEL1310110007#
name: heparan-glucosaminide N-acetyltransferase, lysosomal

metaM mi145p c
is: CHEBI:203600
is: SBO:0000247
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
constant: false
is: HMDB01498
type: Species
has only substance units: false
initial concentration: 1.0

metaR PItg
fast: false
reversible: false
product: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
name: phosphate transport, Golgi apparatus
is described by: ECO:0000000
kinetic law: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110007#_a29e5da0_2a69_4f5e_991b_74b0b8ed0825
type: Species
is encoded by: hsa:6514
name: SLC2A2
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: P11168
is: SBO:0000252

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_5461f077_0e73_4044_baae_9e25dd8709a2
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: CHKB
boundary condition: true
type: Species
is encoded by: hsa:1120
is: A0PJM6
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_000449ab_3616_4658_9c0b_3a7ee0289df4
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:952
initial amount: NaN
is: P28907
type: Species
name: CD38

metaM 2decdicoa m
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
name: 2,7-decadienoylcoa
constant: false
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0

metaM odecoa m
is: CHEBI:57387
initial concentration: 1.0
constant: false
is: HMDB01322
name: Octadecenoyl-CoA (n-C18:1CoA)
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_78656b00_90d6_471a_9e27_791107fafba5
boundary condition: true
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:26
is: SBO:0000252
name: ABP1
is: P19801

metaR FAOXC164C165m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

metaR ADNCYC
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
fast: false
name: adenylate cyclase
is version of: http://identifiers.org/ec-code/4.6.1.1
reversible: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
modifier: MODEL1310110007#

metaR FAOXC141C121x
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C14:1-->C12:1)x
type: Reaction

metaR S6TASE25ly
is described by: ECO:0000000
name: galactose-6-sulfate sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: true
product: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110007#
fast: false
type: Reaction

metaM prostge2 c
name: prostaglandin E2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
constant: false
is: HMDB01220
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:606564
type: Species
boundary condition: false

metaR EX gsn LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Guanosine
type: Reaction

metaM cmpacna c
constant: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
boundary condition: false
has only substance units: false
is: HMDB01176
type: Species
initial concentration: 1.0
is: CHEBI:57812
initial amount: NaN
name: CMP-N-acetyl-beta-neuraminate(2-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_3cb841cf_e7ae_4e30_b0ec_b0e9550c2941
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1340
type: Species
name: COX6B1
constant: false
boundary condition: true
is: SBO:0000252
is: P14854
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_deab29e5_c08e_4ae6_8226_5d91b045927e
name: ADCY10
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:55811
is: SBO:0000252
initial concentration: NaN
is: F5GWS5
initial amount: NaN
constant: false

metaR ITPtn
is: SBO:0000185
kinetic law: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110007#
name: ITP nuclear transport

http://identifiers.org/biomodels.db/MODEL1310110007#_01f49b49_beca_47d9_be2f_858bbdf00905
name: _AI653169_1_c
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI653169
type: Species

metaR PROSTGE1t
modifier: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
name: prostaglandin transport via bicarbonate countertransport
reversible: true
type: Reaction
kinetic law: MODEL1310110007#
is: SBO:0000185
fast: false

metaR r0202
fast: false
reactant: MODEL1310110007#
reversible: true
kinetic law: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
product: MODEL1310110007#
type: Reaction
is: SBO:0000176
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8

http://identifiers.org/biomodels.db/MODEL1310110007#_1a1557d4_1c90_4493_84a4_15be686ce46f
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:4695
name: NDUFA2
is: SBO:0000252
type: Species
initial concentration: NaN
is: O43678

http://identifiers.org/biomodels.db/MODEL1310110007#_9d6efba2_b98d_4b61_a246_7975155e6fe6
is: Q02218
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:4967
is: SBO:0000252
boundary condition: true
name: OGDH
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_8557400f_e571_4f4a_9aea_8ddc5ddfa967
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:1581
has only substance units: false
boundary condition: true
is: P22680
initial amount: NaN
name: CYP7A1

http://identifiers.org/biomodels.db/MODEL1310110007#_8c6994e4_9d41_4120_8b61_92d1e8f0e2c5
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:5150
name: PDE7A
initial amount: NaN
boundary condition: true
has only substance units: false

metaM g3p c
is: CHEBI:58027
name: Glyceraldehyde 3-phosphate
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3930
type: Species
is: HMDB01112
is: C00661
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false

metaR IDOAASE2ly
product: MODEL1310110007#
reversible: false
fast: false
modifier: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.76
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
name: alpha-L-iduronidase, lysosomal
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is described by: ECO:0000000
type: Reaction

metaM hs deg17 l
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
is: HMDB02704
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
initial amount: NaN
is: CHEBI:21338
boundary condition: false
name: heparan sulfate, degradation product 17

http://identifiers.org/biomodels.db/MODEL1310110007#_81e45458_0721_4ab8_a30a_002af3bdcde7
name: MECR
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:51102
is: Q9BV79

metaM adn c
is: HMDB00050
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: CHEBI:16335
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: C00212
type: Species
name: Adenosine

metaM mev R x
constant: false
is: HMDB00227
is: CHEBI:36464
name: (R)-mevalonate
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343

metaR r0650
reversible: true
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.1.1.36
fast: false
modifier: MODEL1310110007#
reactant: MODEL1310110007#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
product: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_b9b21244_b074_4e93_8fb0_bd89f61d396e
constant: false
name: PKLR
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5313
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_faa47927_e3c7_401c_9dac_fc9d9e8388bb
name: PIP4K2C
is: SBO:0000252
is: B3KQV3
boundary condition: true
initial concentration: NaN
is encoded by: hsa:79837
constant: false
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_115e87ee_2020_44fa_be00_a3ac067e0a02
is encoded by: hsa:26227
is: O43175
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: PHGDH

metaR FAEL184
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
is: SBO:0000176
type: Reaction
reversible: false
name: fatty-acyl-CoA elongation (n-C20:4CoA)
product: MODEL1310110007#
fast: false

metaR GTHPe
is version of: http://identifiers.org/ec-code/1.11.1.9
product: MODEL1310110007#
reactant: MODEL1310110007#
name: glutathione peroxidase (e)
notes: GENE_ASSOCIATION: (2878.1) or (257202.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:3619451 NOTES:SAB
fast: false
is: SBO:0000176
reversible: true
modifier: MODEL1310110007#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_86ed3f7c_f60b_401a_aa4b_db394ca1f7ea
type: Species
initial amount: NaN
is encoded by: hsa:9374
name: PPT2
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is: Q9UMR5
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_69597452_2089_45aa_be01_413391d00146
type: Species
is encoded by: hsa:6817
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
name: SULT1A1

metaM prostge2 e
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: SBO:0000247
name: prostaglandin E2(1-)
initial concentration: 1.0
has only substance units: false
is: CHEBI:606564
type: Species
boundary condition: false
constant: false
is: HMDB01220

metaR CHOLESTle
reactant: MODEL1310110007#
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
modifier: MODEL1310110007#
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.1.13
reversible: false
is: SBO:0000176
name: hydrolysis of cholesterol ester by cholesterol esterase

metaM pmtcrn r
type: Species
name: L-palmitoylcarnitine
initial amount: NaN
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: CHEBI:17490
initial concentration: 1.0
constant: false
is: HMDB00222
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR CYSGLTH
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
product: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
name: Glutathione:cystine oxidoreductase
reversible: true
kinetic law: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000000

W3 CDTF: Thu Aug 30 18:18:44 BST 2012

metaR TMDS
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (7298.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.1.1.45 Confidence Level: 4 AUTHORS: PMID:14967037,PMID:2243092 NOTES:
name: thymidylate synthase
reactant: MODEL1310110007#
fast: false
product: MODEL1310110007#
reversible: false
is version of: http://identifiers.org/ec-code/2.1.1.45
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_55eb4a63_c34d_4934_8975_d739990cb6b6
boundary condition: true
is encoded by: hsa:3948
initial concentration: NaN
has only substance units: false
name: LDHC
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is: P07864

http://identifiers.org/biomodels.db/MODEL1310110007#_995517df_2e9f_4945_8f3e_37f5ef9fa443
type: Species
name: _AA081045_1_c
is encoded by: hsa:AA081045
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_6cd75709_1e73_490e_b717_ea4b16e9ae10
is encoded by: hsa:622
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
name: BDH1
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_26c2578c_02c1_40e5_83c7_7de46eadafb6
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:3032
name: HADHB
is: SBO:0000252
has only substance units: false
type: Species
is: P55084
initial concentration: NaN

metaR r1050
product: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
is: SBO:0000185
type: Reaction
reversible: true
name: Vesicular transport
kinetic law: MODEL1310110007#

metaR r2361
is: SBO:0000185
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110007#
type: Reaction
name: Organic anion transporter 5 Utilized transport
fast: false

metaR DMNONCRNCPT2
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000000
fast: false
name: DMNONCRNCPT2
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
kinetic law: MODEL1310110007#
type: Reaction

metaM succoa m
is: SBO:0000247
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
is: HMDB01022
constant: false
has only substance units: false
is: CHEBI:57292
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
name: Succinyl-CoA

metaM pap g
name: adenosine 3',5'-bismonophosphate(4-)
boundary condition: false
type: Species
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00061
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58343
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054

metaR r1668
reversible: true
is described by: ECO:0000000
product: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110007#
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_3564e1ad_2c7e_4c2c_a6e5_753e91775eab
initial amount: NaN
name: GALK2
is: Q01415
constant: false
initial concentration: NaN
is encoded by: hsa:2585
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR OCCOAtm
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: Octanoyl-CoA transport, diffusion
fast: false
reactant: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
reversible: false
kinetic law: MODEL1310110007#

metaM mescon m
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
boundary condition: false
is: HMDB00749
initial concentration: 1.0
initial amount: NaN
name: Mesaconate
is: CHEBI:36986
constant: false
type: Species

metaM T antigen g
has only substance units: false
constant: false
is: CHEBI:22783
boundary condition: false
initial amount: NaN
notes: FORMULA: C14H24NO10X CHARGE: 0
initial concentration: 1.0
type: Species
name: T antigen (core 1)
is: SBO:0000247

metaR NDPK2
name: nucleoside-diphosphate kinase (ATP:UDP)
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110007#
fast: false
reversible: true
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110007#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110007#

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_7c903770_aee3_4e56_9775_fa7ad83645a6
constant: false
is: P22392
boundary condition: true
is encoded by: hsa:4831
has only substance units: false
initial amount: NaN
name: NME2
initial concentration: NaN
type: Species
is: SBO:0000252

metaM 4ppcys c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: C04352
type: Species
is: SBO:0000247
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
constant: false
has only substance units: false
is: CHEBI:59458
initial amount: NaN
is: HMDB01117

metaR r0390
type: Reaction
is: SBO:0000176
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
fast: false
kinetic law: MODEL1310110007#
reversible: true
reactant: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_c2b4b998_0777_482d_a394_6b39f21d0e3a
name: ALDH9A1
is encoded by: hsa:223
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: P49189
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_05c4e09c_a609_4faf_a838_ab176dbc737c
has only substance units: false
initial amount: NaN
is: Q9NPC4
is encoded by: hsa:53947
constant: false
type: Species
is: SBO:0000252
boundary condition: true
name: A4GALT
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_6eb2bb75_80b3_4e17_9eb3_320b636ec938
initial amount: NaN
name: SLC38A5
initial concentration: NaN
is encoded by: hsa:92745
is: SBO:0000252
type: Species
constant: false
is: Q8WUX1
has only substance units: false
boundary condition: true

metaM glyc R c
is: HMDB00139
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: CHEBI:16659
initial amount: NaN
boundary condition: false
has only substance units: false
name: D-glycerate

metaR CHAT
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
reversible: true
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.3.1.6
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
name: Choline O-acetyltransferase
fast: false
product: MODEL1310110007#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269

metaR FATP8t
reversible: true
type: Reaction
modifier: MODEL1310110007#
fast: false
name: fatty acid electroneutral transport
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is: SBO:0000185
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.7
reactant: MODEL1310110007#

metaR r2360
reactant: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110007#
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110007#_899e7b52_7b2a_40a4_b2fa_b9e1878763d5
is: B4DK61
name: ACOX1
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:51
initial amount: NaN

metaR HYXNt
name: Hypoxanthine transport
is described by: ECO:0000269
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
kinetic law: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
modifier: MODEL1310110007#
reversible: true
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_a66eab60_f023_41f8_8514_4298f5230027
constant: false
initial amount: NaN
is encoded by: hsa:3636
initial concentration: NaN
has only substance units: false
name: INPPL1
is: SBO:0000252
is: O15357
type: Species
boundary condition: true

metaR r1667
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reactant: MODEL1310110007#
reversible: true
is described by: ECO:0000000
product: MODEL1310110007#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_cc2d3c7a_29c1_4eae_b259_f69fd274ad90
is: Q16222
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false
name: UAP1
is encoded by: hsa:6675
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_ddede96a_b16d_413f_aca9_82ff6cbbb332
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is: O95528
name: SLC2A10
constant: false
boundary condition: true
is encoded by: hsa:81031

metaR NDPK1
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110007#
fast: false
is described by: ECO:0000134
reactant: MODEL1310110007#
modifier: MODEL1310110007#
name: nucleoside-diphosphate kinase (ATP:GDP)
product: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction

metaR DOLPGT2 Ler
is version of: http://identifiers.org/ec-code/2.4.1.265
fast: false
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
reactant: MODEL1310110007#
modifier: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD

http://identifiers.org/biomodels.db/MODEL1310110007#_3dac00c7_c74d_4ba1_8fb7_5f57fbb4198a
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:2348
constant: false
name: FOLR1
initial concentration: NaN

metaR GLYPHEHYc
product: MODEL1310110007#
name: hydrolysis of glycylphenylalanine
kinetic law: MODEL1310110007#
type: Reaction
fast: false
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.

metaR r0391
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
kinetic law: MODEL1310110007#
reversible: true
reactant: MODEL1310110007#
product: MODEL1310110007#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11

metaM dolglcp L r
boundary condition: false
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
is: CHEBI:15812
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
type: Species

metaM 3hexdtetcoa m
boundary condition: false
constant: false
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
name: 3,7,10,13-hexadecatetraenoylcoa
is: HMDB02288
initial amount: NaN
has only substance units: false

metaM man c
initial amount: NaN
is: HMDB00169
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:16024
name: D-Mannose
is: C00159
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_e9cac83d_d85c_4fee_830d_51c837b8be6f
constant: false
is: SBO:0000252
is encoded by: hsa:84693
type: Species
has only substance units: false
boundary condition: true
is: Q96PE7
initial amount: NaN
name: MCEE
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_925779ad_13d0_4814_9ce9_7e3765d65368
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
name: _LOC727762_1_m
is: SBO:0000252
has only substance units: false
is encoded by: hsa:LOC727762
boundary condition: true

metaR r2363
reversible: true
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110007#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
type: Reaction
is: SBO:0000185
reactant: MODEL1310110007#

metaR r1052
name: Vesicular transport
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
product: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110007#_848874ea_de45_4ba0_821a_4d4dd7ba6c7b
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: PANK4
type: Species
initial concentration: NaN
has only substance units: false
is: Q9NVE7
is encoded by: hsa:55229

http://identifiers.org/biomodels.db/MODEL1310110007#_fb68d307_ba59_442a_8054_246bc74d1aaa
is encoded by: hsa:27068
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: PPA2

http://identifiers.org/biomodels.db/MODEL1310110007#_3ffc02d5_0ac3_4317_ae9e_259f5d3234ab
is: B7Z6M3
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
name: DGKZ
is: SBO:0000252
is encoded by: hsa:8525
boundary condition: true
type: Species

metaM 3pg c
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3497
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00807
name: 3-Phospho-D-glycerate
is: CHEBI:58272
is: C00197
boundary condition: false

metaR UAGDP
is version of: http://identifiers.org/ec-code/2.7.7.23
reversible: false
product: MODEL1310110007#
fast: false
name: UDP-N-acetylglucosamine diphosphorylase
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
reactant: MODEL1310110007#
is: SBO:0000176
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_4ee64e39_c76d_4a1b_93d0_dd2fe44010ea
name: NDUFS2
boundary condition: true
is: B7Z792
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4720
initial amount: NaN
type: Species
constant: false
is: SBO:0000252

metaR NDPK4
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is: SBO:0000176
reversible: true
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:dTDP)
reactant: MODEL1310110007#

metaR r0311
kinetic law: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110007#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
modifier: MODEL1310110007#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.9

metaM ksi deg15 l
name: keratan sulfate I, degradation product 15
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00143
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
initial amount: NaN
is: CHEBI:12936

metaM 4mlacac c
initial concentration: 1.0
name: 4-maleylacetoacetate
is: SBO:0000247
is: CHEBI:17105
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
constant: false
is: HMDB02052

metaR NRPPHRSFt
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
product: MODEL1310110007#
type: Reaction
fast: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
reversible: false
name: norepinephrine sulfate transport (diffusion)

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaR GLCSGLT1le
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-glucose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

metaR O2Stm
reversible: true
name: superoxide anion transport via diffusion (mitochondria)
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
fast: false
kinetic law: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#

metaM CE4794 m
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
name: cis-6-dodecenoyl-CoA
constant: false
is: SBO:0000247
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
initial concentration: 1.0
is: CHEBI:57923

metaM CE4872 c
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:15748
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00127
is: SBO:0000247
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_aec6d1b6_1778_43a5_8c1a_f04c90482178
type: Species
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6480
name: ST6GAL1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_f4eba2a8_73a4_40f3_b1db_ab846c048556
initial concentration: NaN
is: SBO:0000252
name: AKR1C4
is: P17516
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:1109
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_27c0e8a6_7a57_456c_aa96_28b5ce5ea8eb
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
name: SLC17A3
initial amount: NaN
is: O00476
boundary condition: true
is encoded by: hsa:10786

http://identifiers.org/biomodels.db/MODEL1310110007#_cbcd5a58_a084_4274_8388_aa9312e6ecb3
name: NDUFS3
constant: false
type: Species
has only substance units: false
is encoded by: hsa:4722
initial concentration: NaN
is: O75489
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR r2362
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#

metaM dkmpp c
is: C15650
type: Species
name: 2,3-diketo-5-methylthio-1-phosphopentane
notes: FORMULA: C6H9O6PS CHARGE: -2
initial amount: NaN
is: CHEBI:58828
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR r1051
product: MODEL1310110007#
reactant: MODEL1310110007#
name: Vesicular transport
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
kinetic law: MODEL1310110007#
is: SBO:0000185

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_57fa3909_e016_4430_81e6_23cdd2c264cb
has only substance units: false
name: SLC16A2
initial amount: NaN
constant: false
boundary condition: true
is: P36021
initial concentration: NaN
type: Species
is encoded by: hsa:6567
is: SBO:0000252

metaR GLYt2r
type: Reaction
is described by: ECO:0000304
kinetic law: MODEL1310110007#
fast: false
modifier: MODEL1310110007#
is: SBO:0000185
name: glycine reversible transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reactant: MODEL1310110007#
reversible: true
product: MODEL1310110007#

metaR RE0926E
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
name: RE0926
kinetic law: MODEL1310110007#
type: Reaction
reversible: true
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.1
reactant: MODEL1310110007#

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaM arg L e
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00517
constant: false
name: L-argininium(1+)
is: CHEBI:32682

metaR ASCBt
is described by: ECO:0000000
kinetic law: MODEL1310110007#
is: SBO:0000185
type: Reaction
reversible: true
name: L-ascorbate transport via facilitated diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
reactant: MODEL1310110007#
product: MODEL1310110007#

metaM Rtotal3 e
notes: FORMULA: CO2FULLR3 CHARGE: -1
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:3554
constant: false
type: Species
is: HMDB00244
initial concentration: 1.0
is: C00255
has only substance units: false
name: R total 3 position

metaR P450SCC1m
is: SBO:0000176
product: MODEL1310110007#
reversible: true
kinetic law: MODEL1310110007#
fast: false
name: cholesterol monooxygenase
is described by: ECO:0000134
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
type: Reaction

metaR NDPK3
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
name: nucleoside-diphosphate kinase (ATP:CDP)
is described by: ECO:0000269
product: MODEL1310110007#
type: Reaction
modifier: MODEL1310110007#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110007#_26449eef_3e77_4004_98c5_01a1036cc0fb
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:6579
is: P46721
name: SLCO1A2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_8bdf0e47_20b3_404a_aec5_09f5e34666b2
is: E9PB82
name: HSD17B4
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3295
type: Species
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR r0541
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110007#
reactant: MODEL1310110007#
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
kinetic law: MODEL1310110007#
product: MODEL1310110007#
fast: false
reversible: true

metaR r1669
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reversible: true
product: MODEL1310110007#
is: SBO:0000185
fast: false
type: Reaction

metaR NDP7g
kinetic law: MODEL1310110007#
reversible: false
type: Reaction
product: MODEL1310110007#
modifier: MODEL1310110007#
is: SBO:0000176
name: nucleoside-diphosphatase (UDP), Golgi apparatus
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.6

metaR FPGS6m
name: folylpolyglutamate synthetase (DHF), mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
product: MODEL1310110007#
reversible: false
modifier: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.2.17
is described by: ECO:0000000
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
fast: false

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaR FAOXC221C201x
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

metaR MHISOR
product: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.4.3.21
name: N-Methylhistamine:oxygen oxidoreductase (deaminating)
type: Reaction
modifier: MODEL1310110007#
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.22
fast: false
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Histidine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:12072962,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110007#
is described by: ECO:0000269

metaR AKGDm
is: SBO:0000176
notes: GENE_ASSOCIATION: (4967.2) and (1738.1 and 8050.1) and (1743.1) or (4967.1) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Citric acid cycle EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:1542694 NOTES:EC taken from Ligand TV. Genetic
name: 2-oxoglutarate dehydrogenase
modifier: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.3.1.61
is version of: http://identifiers.org/ec-code/1.8.1.4
fast: false
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.2.4.2
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110007#_c81d465f_5337_4d52_b893_709250291dc9
initial concentration: NaN
is encoded by: hsa:5150
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
name: PDE7A
has only substance units: false
boundary condition: true
is: Q13946

metaR VITD3t2
reactant: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
reversible: false
name: Vitamin D3 uptake
is: SBO:0000185
product: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT

metaR r2365
reactant: MODEL1310110007#
reversible: true
kinetic law: MODEL1310110007#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110007#
is: SBO:0000185
type: Reaction
name: Organic anion transporter 5 Utilized transport

metaM man e
initial amount: NaN
type: Species
is: HMDB00169
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
has only substance units: false
is: CHEBI:16024
constant: false
is: C00159
boundary condition: false
name: D-Mannose
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_9bf8057f_005c_4784_af4d_c6c812166a36
has only substance units: false
is: SBO:0000252
is: Q9HBH5
constant: false
type: Species
name: RDH14
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:57665

metaR r1620
reactant: MODEL1310110007#
product: MODEL1310110007#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM 5dhf m
has only substance units: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
initial amount: NaN
constant: false
name: pentaglutamyl folate (DHF)
is: HMDB06487
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM cholcoaone x
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
initial concentration: 1.0
is: CHEBI:58507
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
has only substance units: false
is: HMDB06891
boundary condition: false

metaR r0394
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reversible: true
fast: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

metaR ACt2r
product: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110007#
name: acetate reversible transport via proton symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
reversible: true
reactant: MODEL1310110007#
is: SBO:0000185

metaR MM8Ber
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (11253.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10409699,PMID:9592125 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.113
reversible: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, endoplasmic reticulum
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
product: MODEL1310110007#

metaR DOLDPP Ler
fast: false
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
is: SBO:0000176
name: Dolichyl-diphosphate phosphohydrolase, human (liver)
product: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.6.1.43
modifier: MODEL1310110007#
reversible: false

metaM nrvnc e
initial concentration: 1.0
initial amount: NaN
is: HMDB02368
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
name: nervonate
has only substance units: false
constant: false
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:32392

metaR RE3004M
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110007#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110007#
is described by: ECO:0000000
modifier: MODEL1310110007#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE3004

metaR GLUCYS
name: Gamma-glutamylcysteine synthetase
notes: GENE_ASSOCIATION: (2729.1) and (2730.1) SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reversible: false
product: MODEL1310110007#
type: Reaction
modifier: MODEL1310110007#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.3.2.2
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#

metaM o2s e
initial amount: NaN
type: Species
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247
is: HMDB02168
constant: false
boundary condition: false
has only substance units: false
name: superoxide
initial concentration: 1.0
is: CHEBI:18421

metaR CYANt
product: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
name: Cyanide transport via diffusion (extracellular to cytosol)
reactant: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
type: Reaction
is described by: ECO:0000000
reversible: true

metaR r1664
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
product: MODEL1310110007#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
fast: false
type: Reaction

metaM txa2 r
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: HMDB01452
boundary condition: false
initial amount: NaN
name: thromboxane A2(1-)
is: SBO:0000247
is: CHEBI:57445
type: Species

metaR PRAGSr
reactant: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110007#
is described by: ECO:0000269
modifier: MODEL1310110007#
name: phosphoribosylglycinamide synthase
is: SBO:0000176
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.1.2.2
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_f259e27a_f89c_4dce_bc73_055e4f58f1fd
is: SBO:0000252
name: ACP5
is: P13686
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:54

metaM etoh c
name: ethanol
initial concentration: 1.0
is: CHEBI:16236
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
is: HMDB00108
constant: false
boundary condition: false
type: Species

metaM for c
name: Formate
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
initial amount: NaN
constant: false
is: C00058
has only substance units: false
is: CHEBI:15740
initial concentration: 1.0
is: HMDB00142
boundary condition: false
is: SBO:0000247
type: Species

metaR GLYtp
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
name: glycine passive transport to peroxisome
reversible: true
product: MODEL1310110007#
is: SBO:0000185

metaM HC01399 m
type: Species
is: CHEBI:27466
boundary condition: false
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
is: SBO:0000247
constant: false
has only substance units: false
name: (S)-3-Hydroxytetradecanoyl-CoA
initial amount: NaN
initial concentration: 1.0

metaR XOL27OHtm
name: 27 hydroxy cholesterol transport
type: Reaction
reversible: true
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
reactant: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#
fast: false
is described by: ECO:0000000

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaM arg L c
is: HMDB00517
boundary condition: false
constant: false
is: CHEBI:32682
name: L-argininium(1+)
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
type: Species
is: SBO:0000247

metaR r2364
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#

metaM pep m
is: C00074
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: Phosphoenolpyruvate
has only substance units: false
is: CHEBI:18021
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
constant: false
type: Species
boundary condition: false
is: HMDB00263

metaR ALAGLYexR
reactant: MODEL1310110007#
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110007#
product: MODEL1310110007#
reversible: true
is: SBO:0000185
fast: false
name: L-alanine/glycine reversible exchange
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110007#_2fa6af58_cee2_43ae_8386_625b098e1938
type: Species
boundary condition: true
is encoded by: hsa:2194
name: FASN
is: SBO:0000252
initial concentration: NaN
constant: false
is: P49327
has only substance units: false
initial amount: NaN

metaM 3aib D m
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
type: Species
name: D-3-Amino-isobutanoate
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: C03265
is: HMDB02299

metaR GLNtN1
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is: SBO:0000185
fast: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000269
modifier: MODEL1310110007#
name: Glutamine transport (Na, H coupled)

metaR EHGLATm
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
fast: false
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
product: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.6.1.1
reversible: false
is: SBO:0000176
is described by: ECO:0000212
type: Reaction

metaR O2Stn
product: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
name: superoxide anion transport via diffusion (nucleus)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110007#_f7616c31_c0f5_4f60_8993_aa03674ed3c4
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: _R39999_1_c
boundary condition: true
is encoded by: hsa:R39999
initial amount: NaN
has only substance units: false

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_b5c26727_e430_4ac0_9dc7_2a09a8981699
constant: false
boundary condition: true
initial amount: NaN
is: E9KL44
name: HADHA
is encoded by: hsa:3030
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_a5c0b3ea_4bec_4e4d_9c92_458fd5b1183a
is: Q9Y2C5
is encoded by: hsa:10050
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: SLC17A4
type: Species
boundary condition: true

metaR r2367
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
reversible: true
fast: false

metaR S6TASE1ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
kinetic law: MODEL1310110007#
type: Reaction
modifier: MODEL1310110007#
fast: false
product: MODEL1310110007#
reactant: MODEL1310110007#

metaR r1622
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110007#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110007#
modifier: MODEL1310110007#

metaR PI5P3K
is version of: http://identifiers.org/ec-code/2.7.1.153
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.137
kinetic law: MODEL1310110007#
is described by: ECO:0000000
reactant: MODEL1310110007#
modifier: MODEL1310110007#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
name: phosphatidylinositol-5-phosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.154
product: MODEL1310110007#
is: SBO:0000176

metaR r0392
type: Reaction
is: SBO:0000176
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
fast: false
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
kinetic law: MODEL1310110007#
reversible: true
reactant: MODEL1310110007#
is described by: ECO:0000000

metaR MTAP
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (4507.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.4.2.28 Confidence Level: 4 AUTHORS: PMID:16000004,PMID:2543672,PMID:3091600 NOTES:
reactant: MODEL1310110007#
name: 5'-methylthioadenosine phosphorylase
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.4.2.28
is described by: ECO:0000269
modifier: MODEL1310110007#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_068cbd1e_d365_4c4e_a10b_18bc8f21a4fe
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: PISD
is encoded by: hsa:23761
initial amount: NaN
has only substance units: false
is: Q9UG56

metaR AKGtp
reversible: true
is: SBO:0000185
type: Reaction
name: AKG transporter, peroxisome
reactant: MODEL1310110007#
fast: false
product: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110007#

metaM xoldiolone c
constant: false
boundary condition: false
type: Species
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
is: SBO:0000247
is: HMDB02197
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:28477

metaM man g
has only substance units: false
is: CHEBI:16024
boundary condition: false
initial concentration: 1.0
name: D-mannose
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: SBO:0000247
constant: false
is: HMDB00169
initial amount: NaN

metaM ksi deg14 l
has only substance units: false
is: HMDB00143
is: SBO:0000247
is: CHEBI:12936
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
name: keratan sulfate I, degradation product 14
constant: false

metaR DOCO13ECOAtxc
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 13-docosenoylcoa into peroxisomes
type: Reaction

metaM for e
initial amount: NaN
constant: false
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: HMDB00142
is: SBO:0000247
name: formate
is: CHEBI:15740
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species

metaR r1666
kinetic law: MODEL1310110007#
is described by: ECO:0000000
modifier: MODEL1310110007#
name: Y+LAT2 Utilized transport
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110007#

metaR RE3556C
product: MODEL1310110007#
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false
is described by: ECO:0000000
name: RE3556
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reversible: true
is: SBO:0000176
type: Reaction

metaM nrvnc c
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:32392
is: SBO:0000247
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
has only substance units: false
name: nervonate
is: HMDB02368
initial concentration: 1.0

metaR GALt4
reactant: MODEL1310110007#
product: MODEL1310110007#
name: galactose transport via sodium symport
kinetic law: MODEL1310110007#
fast: false
modifier: MODEL1310110007#
reversible: true
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
type: Reaction

metaR PItn
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: phosphate transport, nuclear
fast: false
reactant: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_c1f67644_7c30_4bd8_8503_43070e5b769f
type: Species
name: ACSL5
is: Q9ULC5
has only substance units: false
boundary condition: true
is encoded by: hsa:51703
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM etoh e
constant: false
has only substance units: false
is: CHEBI:16236
initial concentration: 1.0
name: ethanol
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
is: HMDB00108

metaM o2s c
is: CHEBI:18421
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
name: superoxide
is: SBO:0000247
boundary condition: false
is: HMDB02168
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
constant: false

metaM andrstndn r
is: HMDB00053
initial concentration: 1.0
is: CHEBI:16422
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
name: androst-4-ene-3,17-dione
notes: FORMULA: C19H26O2 CHARGE: 0 INCHI: InChI=1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00280
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_cdd5887d_d9e3_4037_8e5a_d980cbd9cab5
constant: false
boundary condition: true
is: Q5QPH3
initial amount: NaN
has only substance units: false
name: ACSS2
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:55902

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

metaR GLCAASE1ly
is described by: ECO:0000000
modifier: MODEL1310110007#
name: beta-glucuronidase, lysosomal
reactant: MODEL1310110007#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
kinetic law: MODEL1310110007#
fast: false
is: SBO:0000176
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.31

metaR r1621
is: SBO:0000185
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110007#
modifier: MODEL1310110007#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
reversible: true

metaM forglu c
type: Species
constant: false
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
has only substance units: false
name: N-Formimidoyl-L-glutamate
is: HMDB00854
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18327
is: C00439
boundary condition: false

metaM 5dhf l
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: pentaglutamyl folate (DHF)
is: HMDB06487
constant: false
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1

metaR GALASE10ly
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
modifier: MODEL1310110007#
reversible: false
type: Reaction

metaR r2366
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110007#
type: Reaction
fast: false
reactant: MODEL1310110007#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_462ef328_3666_48ce_b447_2d4795e5a6a9
initial amount: NaN
type: Species
is encoded by: hsa:8704
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: B4GALT2

metaM CE0785 m
name: cis,cis-myristo-5,8-dienoyl-CoA
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:57795

metaM CE0233 c
initial concentration: 1.0
constant: false
is: HMDB01993
is: CHEBI:17899
is: SBO:0000247
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1/C27H48O3/c1-17(7-6-12-25(2,3)30)20-8-9-21-24-22(11-14-27(20,21)5)26(4)13-10-19(28)15-18(26)16-23(24)29/h17-24,28-30H,6-16H2,1-5H3/t17-,18-,19+,20-,21-,22-,23+,24-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE0233
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,27-triol

metaR r0393
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.1.74
modifier: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
product: MODEL1310110007#

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_b3a3773e_e32c_4d3e_8a2e_2cfe52d60365
initial amount: NaN
constant: false
is: E7EPT3
name: ALDH7A1
is: SBO:0000252
is encoded by: hsa:501
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_48b5e001_0be1_4929_b5a3_8fc4601cea70
boundary condition: true
name: CHAT
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1103
is: D3DX95
constant: false
has only substance units: false
type: Species

metaR r0545
modifier: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: true
kinetic law: MODEL1310110007#
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_bca99e9e_4f4f_4ad2_a9da_5f67f26df221
is encoded by: hsa:22978
name: NT5C2
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P49902

metaR r1665
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
product: MODEL1310110007#
fast: false
reversible: true
modifier: MODEL1310110007#

metaR MI1345PP
is version of: http://identifiers.org/ec-code/3.1.3.36
fast: false
product: MODEL1310110007#
is described by: ECO:0000269
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.3.56
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.86
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110007#_1b2768b1_3062_45ac_aa39_d2efad84857c
initial amount: NaN
is encoded by: hsa:1806
has only substance units: false
initial concentration: NaN
is: Q12882
constant: false
name: DPYD
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_8f1a4988_61d6_4efa_9848_3236cb231c9d
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
constant: false
name: GLUL
is: P15104
is: SBO:0000252
is encoded by: hsa:2752
boundary condition: true

metaM ksii core4 e
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
name: keratan sulfate II (core 4-linked)
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:17268
is: HMDB00211
type: Species

metaM HC01231 c
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
name: N-[(R)-pantothenoyl]-L-cysteinate
is: CHEBI:58480
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
type: Species
initial amount: NaN

metaM ksi deg23 l
boundary condition: false
initial amount: NaN
is: HMDB00143
has only substance units: false
name: keratan sulfate I, degradation product 23
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
is: CHEBI:12936
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species

metaM glucys c
has only substance units: false
boundary condition: false
notes: FORMULA: C8H13N2O5S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00487 EHMN_ABBREVIATION: C00669
is: SBO:0000247
type: Species
initial amount: NaN
is: C00669
name: gamma-L-Glutamyl-L-cysteine
initial concentration: 1.0
is: HMDB01049
is: CHEBI:58173
constant: false

metaR GTHO
reversible: false
name: glutathione oxidoreductase
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.7
kinetic law: MODEL1310110007#
is: SBO:0000176
product: MODEL1310110007#
is described by: ECO:0000254
fast: false
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
modifier: MODEL1310110007#
reactant: MODEL1310110007#

metaR r0399
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
is version of: http://identifiers.org/ec-code/1.2.4.2
product: MODEL1310110007#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110007#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
modifier: MODEL1310110007#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110007#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_a99045b6_235b_48c1_a438_142b2a4576e0
is: P11166
is: SBO:0000252
is encoded by: hsa:6513
type: Species
boundary condition: true
initial concentration: NaN
constant: false
name: SLC2A1
has only substance units: false
initial amount: NaN

metaR LNLNCGt
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110007#
reversible: true
product: MODEL1310110007#
kinetic law: MODEL1310110007#
name: fatty acid transport via diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction

metaR GLUDym
product: MODEL1310110007#
reactant: MODEL1310110007#
modifier: MODEL1310110007#
fast: false
is: SBO:0000176
name: glutamate dehydrogenase (NADP), mitochondrial
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.4.1.3
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110007#_7622db60_a7c6_44aa_bbf8_c3e3739ac873
initial amount: NaN
is encoded by: hsa:5294
has part: P48736
constant: false
is: SBO:0000297
type: Species
boundary condition: true
is encoded by: hsa:10870
has part: Q9UBK5
has only substance units: false
initial concentration: NaN
name: HCST:PIK3CG

metaR RTOTAL2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
reversible: true
kinetic law: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
is described by: ECO:0000000
name: RTOTAL2 transport
type: Reaction

metaM glu L l
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00148
name: L-glutamate(1-)
type: Species
has only substance units: false
is: CHEBI:29985
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025

http://identifiers.org/biomodels.db/MODEL1310110007#_1406a551_55f4_48be_9ad2_51d975fe601f
initial amount: NaN
is: SBO:0000252
name: NAGA
initial concentration: NaN
is: P17050
constant: false
boundary condition: true
type: Species
is encoded by: hsa:4668
has only substance units: false

metaM tsul e
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00257
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: SBO:0000247
is: CHEBI:16094
boundary condition: false
name: thiosulfate(2-)
initial concentration: 1.0
type: Species

metaM ksii core2 deg9 l
is: CHEBI:12936
has only substance units: false
constant: false
name: keratan sulfate II (core 2-linked), degradation product 9
is: HMDB00143
is: SBO:0000247
boundary condition: false
notes: FORMULA: C30H50N3O20X CHARGE: 0
initial amount: NaN
initial concentration: 1.0
type: Species

metaR NACUP
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
reactant: MODEL1310110007#
type: Reaction
fast: false
kinetic law: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#
name: Nicotinic acid uptake

metaR r1611
is: SBO:0000185
product: MODEL1310110007#
reversible: true
type: Reaction
kinetic law: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaM dheas c
type: Species
is: CHEBI:57905
is: HMDB01032
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
is: SBO:0000247
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
initial amount: NaN
boundary condition: false
constant: false

metaM HC02210 c
initial amount: NaN
is: SBO:0000247
is: CHEBI:34939
has only substance units: false
type: Species
name: prostaglandin-d3
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_d8abb636_3a82_4f5c_8958_f453ed052902
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR KCCt
type: Reaction
product: MODEL1310110007#
is: SBO:0000185
reversible: true
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
name: K+-Cl- cotransport
is described by: ECO:0000269
modifier: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_d6685d88_8a80_44c3_963a_6a1033021a11
is encoded by: hsa:3295
type: Species
is: E9PB82
name: HSD17B4
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR r2368
is: SBO:0000185
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
product: MODEL1310110007#
fast: false
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_966f3a31_1dba_48aa_abb5_61dd58a9051c
type: Species
boundary condition: true
initial amount: NaN
is: P20132
is encoded by: hsa:10993
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
name: SDS

metaM 2dr5p c
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
name: 2-deoxy-D-ribose 5-phosphate(2-)
has only substance units: false
is: CHEBI:57651
initial amount: NaN
is: HMDB01031

metaR GLYtm
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
name: glycine passive transport to mitochondria
fast: false
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#

metaR r1563
product: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000185

metaR GTHP
is version of: http://identifiers.org/ec-code/1.11.1.9
fast: false
modifier: MODEL1310110007#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
type: Reaction
name: glutathione peroxidase
kinetic law: MODEL1310110007#
is: SBO:0000176
product: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.11.1.12
reversible: true
is version of: http://identifiers.org/ec-code/1.11.1.15

metaM lgt S c
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
constant: false
is: CHEBI:57474
is: HMDB01066
name: (R)-S-lactoylglutathionate(1-)
boundary condition: false
initial concentration: 1.0

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_d25c248e_d37c_4d0c_a932_1a22c317f368
initial amount: NaN
name: ALDH3B2
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:222
boundary condition: true
constant: false
is: P48448

metaR CRVNCtr
reversible: true
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110007#_cd63c918_fe5a_456e_87e7_c1a42cfcd45a
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:353
name: APRT
is: P07741
is: SBO:0000252

metaR PRO Dtde
kinetic law: MODEL1310110007#
product: MODEL1310110007#
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110007#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
type: Reaction
name: D-proline transport, extracellular

http://identifiers.org/biomodels.db/MODEL1310110007#_9ee6f29a_ff67_4832_baea_ff6eb61d908c
initial amount: NaN
has only substance units: false
is encoded by: hsa:1723
initial concentration: NaN
is: Q02127
type: Species
constant: false
is: SBO:0000252
boundary condition: true
name: DHODH

metaR FUMm
is: SBO:0000176
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
modifier: MODEL1310110007#
is described by: ECO:0000134
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.2.1.2
type: Reaction
fast: false
name: fumarase, mitochondrial
reversible: true

metaR GFUCS
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: NOTES:Both human and Escherichia coli enzymes can use NADH in place of NADPH to a slight extent. IT
is version of: http://identifiers.org/ec-code/1.1.1.271
type: Reaction
is described by: ECO:0000000
name: GDP-L-fucose synthase
product: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
modifier: MODEL1310110007#

metaM dopa c
is: HMDB00073
is: SBO:0000247
has only substance units: false
is: CHEBI:59905
constant: false
initial amount: NaN
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
boundary condition: false
initial concentration: 1.0
type: Species
name: dopaminium(1+)

metaM acngalgbside hs g
name: sialyl galactosylgloboside
type: Species
constant: false
is: SBO:0000247
is: HMDB03406
initial concentration: 1.0
is: CHEBI:16523
initial amount: NaN
has only substance units: false
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_1c508fe6_8c51_473b_9bac_01c227acfdbc
name: ALDH3A2
is encoded by: hsa:224
initial amount: NaN
initial concentration: NaN
is: P51648
has only substance units: false
type: Species
constant: false
is: SBO:0000252
boundary condition: true

metaR LYStm
fast: false
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
product: MODEL1310110007#
is described by: ECO:0000269
reversible: true
is: SBO:0000185
type: Reaction
name: Lysine mitochondrial transport via ornithine carrier
reactant: MODEL1310110007#

metaM ksii core2 deg1 l
constant: false
type: Species
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 1
has only substance units: false
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
is: SBO:0000247
is: HMDB00868
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57737

metaR GGH 5DHFl
kinetic law: MODEL1310110007#
reversible: false
type: Reaction
name: Gamma-glutamyl hydrolase (5DHF), lysosomal
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.4.19.9

metaR RE0689E
is version of: http://identifiers.org/ec-code/1.4.3.22
reactant: MODEL1310110007#
is: SBO:0000176
type: Reaction
name: RE0689
product: MODEL1310110007#
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
fast: false
reversible: false
kinetic law: MODEL1310110007#
is described by: ECO:0000000

metaR RE1526M
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110007#
reversible: true
name: RE1526
type: Reaction
reactant: MODEL1310110007#
modifier: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
product: MODEL1310110007#

metaR DOLPMT1 Ler
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
reactant: MODEL1310110007#
modifier: MODEL1310110007#
reversible: false
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.258

metaM 4mop e
name: 4-methyl-2-oxopentanoate
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
boundary condition: false
type: Species
is: HMDB00695
constant: false
initial concentration: 1.0
is: CHEBI:17865
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_d46e2f63_95cb_4611_9e4c_78de1b6d87ec
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
name: LHPP
is: Q9H008
boundary condition: true
is encoded by: hsa:64077
constant: false

metaR r1612
product: MODEL1310110007#
reversible: true
modifier: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR TRDR
reactant: MODEL1310110007#
type: Reaction
reversible: false
product: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110007#
name: thioredoxin reductase (NADPH)
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
modifier: MODEL1310110007#
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.9

http://identifiers.org/biomodels.db/MODEL1310110007#_6b229f19_88fd_4468_8d5c_84e331b69937
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: A8K5J1
is encoded by: hsa:7372
constant: false
type: Species
boundary condition: true
name: UMPS
initial amount: NaN

metaR r2369
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reversible: true
fast: false

metaR PPCOAOm
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
fast: false
reversible: false
modifier: MODEL1310110007#
reactant: MODEL1310110007#
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110007#

metaR PYRt2m
type: Reaction
name: pyruvate mitochondrial transport via proton symport
kinetic law: MODEL1310110007#
fast: false
modifier: MODEL1310110007#
product: MODEL1310110007#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD

metaR r1562
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true

metaR GALASE19ly
kinetic law: MODEL1310110007#
reversible: false
modifier: MODEL1310110007#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110007#

metaR FAOXC11
reversible: false
type: Reaction
reactant: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211 1 round of beta ox of branched chain FA from peroxisome NJ
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110007#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110007#_96a0c38b_2a6f_4cab_924e_621beb969799
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:8693
has only substance units: false
name: GALNT4
initial concentration: NaN
is: Q8N4A0
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_4eccb79f_f37f_45f5_a68a_048df5555e79
is encoded by: hsa:5169
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: ENPP3
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: Q308M7

metaM tsul c
type: Species
constant: false
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
name: thiosulfate(2-)
boundary condition: false
initial amount: NaN
is: HMDB00257
is: SBO:0000247
is: CHEBI:16094
has only substance units: false
initial concentration: 1.0

metaM coa n
constant: false
name: coenzyme A(4-)
is: CHEBI:57287
boundary condition: false
is: HMDB01423
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial amount: NaN

metaR CO2tm
is described by: ECO:0000000
kinetic law: MODEL1310110007#
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110007#
name: CO2 transport (diffusion), mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
reactant: MODEL1310110007#
type: Reaction

metaM ei11ecoa x
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
name: 11-eicosenoylcoa
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
type: Species

metaM mev R c
is: CHEBI:36464
has only substance units: false
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
is: SBO:0000247
boundary condition: false
type: Species
name: (R)-mevalonate
initial amount: NaN
is: HMDB00227
initial concentration: 1.0
constant: false

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaR CRNtx
type: Reaction
product: MODEL1310110007#
reversible: true
name: carnitine transport peroxisome to mitochondria
is described by: ECO:0000000
fast: false
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
is: SBO:0000185
kinetic law: MODEL1310110007#

metaM 4ppcys m
is: HMDB01117
has only substance units: false
boundary condition: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
constant: false
type: Species
initial concentration: 1.0
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
initial amount: NaN
is: CHEBI:59458
is: SBO:0000247

metaR r1613
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
product: MODEL1310110007#
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110007#_6f3d99b5_71ea_4ada_9920_977646804a2f
is: SBO:0000252
type: Species
is encoded by: hsa:51727
constant: false
is: B2R6S5
initial concentration: NaN
initial amount: NaN
name: CMPK1
boundary condition: true
has only substance units: false

metaR GALASE4ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110007#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
name: beta-galactosidase, lysosomal
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110007#

metaR NACHEX17ly
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110007#
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
is: SBO:0000176
fast: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_cb2b920d_a7cf_4f9c_9ffb_13db9695ef85
name: CPT1B
boundary condition: true
constant: false
is: E9PCP2
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1375
type: Species

metaR r1565
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
product: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110007#
fast: false
reactant: MODEL1310110007#

metaR UDPGLCAter
kinetic law: MODEL1310110007#
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
reversible: true
type: Reaction
modifier: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110007#
is: SBO:0000185
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_aa5aa283_95cc_476a_be51_6844e1d3ec16
initial concentration: NaN
is: F8WDN9
boundary condition: true
has only substance units: false
name: PPA2
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:27068

metaR r0186
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
modifier: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false

metaR 3AIB Dtm
is described by: ECO:0000134
name: transport of 3aib_D into mitochondria
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:
reversible: true
type: Reaction
product: MODEL1310110007#
fast: false
is: SBO:0000185

metaR LNSTLSr
is version of: http://identifiers.org/ec-code/5.4.99.7
fast: false
modifier: MODEL1310110007#
name: lanosterol synthase
reactant: MODEL1310110007#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000134
type: Reaction

metaR BDMT L
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (liver)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.142
type: Reaction
reversible: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110007#
fast: false
product: MODEL1310110007#
is described by: ECO:0000000

metaR FAOXC101C102m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

metaM dheas e
is: SBO:0000247
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
is: HMDB01032
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
is: CHEBI:57905

http://identifiers.org/biomodels.db/MODEL1310110007#_c801be01_1610_4a4c_9d0d_40c51c3375a0
constant: false
is: SBO:0000252
has only substance units: false
name: ACO2
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:50
is: Q99798
type: Species

metaM leuktrE4 e
is: SBO:0000247
is: CHEBI:57462
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: HMDB02200
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
name: leukotriene E4(1-)
type: Species
has only substance units: false

metaM 4abutn e
constant: false
boundary condition: false
name: 4-ammoniobutanal
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: SBO:0000247
has only substance units: false
is: CHEBI:58264
is: HMDB01080
type: Species
initial concentration: 1.0
initial amount: NaN

metaM arachdcoa c
type: Species
is: CHEBI:57368
initial amount: NaN
is: SBO:0000247
is: HMDB06523
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
constant: false
name: arachidonoyl-CoA(4-)

metaR UPPN
is: SBO:0000176
modifier: MODEL1310110007#
reversible: false
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
name: b-ureidopropionase
kinetic law: MODEL1310110007#
is described by: ECO:0000269
reactant: MODEL1310110007#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.6
product: MODEL1310110007#

metaM dcsptn1coa m
is: C16173
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: HMDB06513
is: http://identifiers.org/pubchem.compound/47205483
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1

metaM 3dodtricoa m
constant: false
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: HMDB03952
has only substance units: false
is: C05280
name: 3,6,9-dodecatrienoylcoa
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_155df0a5_2d02_44af_9b45_c15dd4fecf16
name: PIP4K2B
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:8396
is: SBO:0000252
is: P78356
constant: false
boundary condition: true
has only substance units: false

metaM CE5125 x
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00127
type: Species
name: (2S)-pristanoyl-CoA
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5125
constant: false
has only substance units: false
is: CHEBI:15748
is: SBO:0000247

metaM coa m
is: HMDB01423
is: SBO:0000247
type: Species
is: C00010
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287
boundary condition: false
name: Coenzyme A

metaR B3GNT39g
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110007#
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
fast: false
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_6158b7db_f96b_45e5_a0b4_e96dc6b1e6ef
has only substance units: false
initial concentration: NaN
is: P07327
is encoded by: hsa:124
initial amount: NaN
is: SBO:0000252
name: ADH1A
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_92502b76_106c_4ec6_8a18_efb906973c6f
initial amount: NaN
is: Q9Y259
type: Species
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1120
name: CHKB

metaM ha deg1 l
initial concentration: 1.0
notes: FORMULA: C22H33N2O16 CHARGE: -1
name: hyaluronan degradation product 1
constant: false
is: CHEBI:16336
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species

metaM 4mop c
initial amount: NaN
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:17865
is: HMDB00695
constant: false
name: 4-methyl-2-oxopentanoate
has only substance units: false

metaR MECOAS1m
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110007#
name: mesaconate--CoA ligase (GDP-forming)
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
type: Reaction
reversible: true
product: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000304
is: SBO:0000176
fast: false
reactant: MODEL1310110007#

metaR r1614
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110007#
reversible: true
type: Reaction
reactant: MODEL1310110007#
fast: false
modifier: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110007#_e273f6e5_2f99_4410_a2eb_823f70ca4474
initial concentration: NaN
type: Species
is encoded by: hsa:641649
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: C9JZ62
name: TMEM91
constant: false

metaR r2443
is: SBO:0000185
reversible: false
reactant: MODEL1310110007#
product: MODEL1310110007#
fast: false
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR r1564
is described by: ECO:0000000
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
type: Reaction
product: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM dopa e
boundary condition: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
initial concentration: 1.0
type: Species
name: dopaminium(1+)
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00073
is: CHEBI:59905

metaR PTE4x
is version of: http://identifiers.org/ec-code/3.1.2.2
product: MODEL1310110007#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
fast: false
reactant: MODEL1310110007#
name: peroxisomal acyl-CoA thioesterase
type: Reaction
kinetic law: MODEL1310110007#
is: SBO:0000176
modifier: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_2fca6967_3198_4776_9266_2b7e877066ef
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: RHAG
initial amount: NaN
is: Q96E98
constant: false
is encoded by: hsa:6005
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_ef82b8a0_e019_4066_a4e7_9a3710f8e9f5
initial concentration: NaN
constant: false
is: P43007
has only substance units: false
initial amount: NaN
type: Species
name: SLC1A4
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6509

metaM fpram c
initial concentration: 1.0
is: SBO:0000247
type: Species
is: C04640
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
boundary condition: false
is: HMDB06211
has only substance units: false
is: CHEBI:58478
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
initial amount: NaN
constant: false

metaR RE3218C
modifier: MODEL1310110007#
reversible: true
product: MODEL1310110007#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110007#
name: RE3218
is version of: http://identifiers.org/ec-code/3.1.6.2
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
kinetic law: MODEL1310110007#
fast: false

metaM HC02217 e
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial concentration: 1.0
is: CHEBI:27647
name: prostaglandin-g2
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false

metaM dad 2 c
boundary condition: false
initial concentration: 1.0
is: HMDB00101
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
is: SBO:0000247
type: Species
name: 2-deoxyadenosine
is: CHEBI:17256
initial amount: NaN
constant: false
has only substance units: false

metaM pmtcrn c
name: L-palmitoylcarnitine
initial amount: NaN
constant: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
boundary condition: false
is: SBO:0000247
is: CHEBI:17490
is: HMDB00222
initial concentration: 1.0
type: Species
has only substance units: false

metaR r0774
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110007#
reversible: true
reactant: MODEL1310110007#
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_dd51fbaa_0456_435b_9617_12617cc25c91
has only substance units: false
constant: false
type: Species
name: NT5C1B
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:93034
is: Q96P26

http://identifiers.org/biomodels.db/MODEL1310110007#_7231479a_cad7_4ba2_8f67_a7cbabcda3a9
is encoded by: hsa:5293
is: SBO:0000252
name: PIK3CD
is: A7E2E0
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_35b48a5c_cd1b_482c_988c_825d6699bade
type: Species
has only substance units: false
is encoded by: hsa:9651
constant: false
name: PLCH2
initial concentration: NaN
is: O75038
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM 12ppd S c
is: HMDB06213
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
has only substance units: false
is: CHEBI:29002
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
name: (S)-propane-1,2-diol

metaR BTND1
fast: false
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.12
modifier: MODEL1310110007#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:IT
product: MODEL1310110007#
is: SBO:0000176
name: biotinidase (biotin)

metaR r1659
product: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_08ca1b82_93f9_4f37_9e89_46c647570fcf
has only substance units: false
is: SBO:0000252
type: Species
name: AMPD2
constant: false
is: B2RB47
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:271

http://identifiers.org/biomodels.db/MODEL1310110007#_18a226e1_ec13_46a6_a34f_74eb456d22bc
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
type: Species
name: _AA664770_1_m
is encoded by: hsa:AA664770
is: SBO:0000252
has only substance units: false

metaM udp e
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00295
name: UDP(3-)
is: CHEBI:58223
boundary condition: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015

metaR LSTO1r
kinetic law: MODEL1310110007#
fast: false
is described by: ECO:0000269
type: Reaction
reversible: false
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
modifier: MODEL1310110007#
name: Lathosterol oxidase
product: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.21.6

http://identifiers.org/biomodels.db/MODEL1310110007#_f6429850_e5c9_44cb_8761_67a470098949
name: HAO2
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:51179
has only substance units: false

metaM 3aib D e
boundary condition: false
initial concentration: 1.0
is: C03265
type: Species
name: D-3-Amino-isobutanoate
constant: false
is: HMDB02299
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715

http://identifiers.org/biomodels.db/MODEL1310110007#_fd7c474b_9ccb_4a52_8839_665afbb85c80
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: Q9BQG2
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:83594
type: Species
name: NUDT12

metaR RE0915E
kinetic law: MODEL1310110007#
is: SBO:0000176
name: RE0915
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.17
fast: false
reversible: true
product: MODEL1310110007#
is described by: ECO:0000000
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_d83689f2_18f4_4e64_a3cc_486798366215
constant: false
is: SBO:0000252
is: Q6I9V5
initial concentration: NaN
is encoded by: hsa:293
has only substance units: false
name: SLC25A6
initial amount: NaN
boundary condition: true
type: Species

metaR r1495
is described by: ECO:0000000
reactant: MODEL1310110007#
product: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:11819755,PMID:17404808,PMID:6384004 NOTES:
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
type: Reaction

metaR FAOXC61m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

metaR r0539
product: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.34
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110007#
fast: false

metaR DCYTDn
reversible: false
name: deoxycytidine deaminase, nuclear
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
kinetic law: MODEL1310110007#
is described by: ECO:0000254
is: SBO:0000176
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.5.4.5
type: Reaction
modifier: MODEL1310110007#
reactant: MODEL1310110007#
fast: false

metaR r1615
reversible: true
product: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110007#
is described by: ECO:0000000
modifier: MODEL1310110007#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR HSD3A1r
is described by: ECO:0000269
reversible: true
type: Reaction
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.225
reactant: MODEL1310110007#
is: SBO:0000176
fast: false
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
product: MODEL1310110007#

metaR GALtly
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
kinetic law: MODEL1310110007#
fast: false
is: SBO:0000185
reactant: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
name: galactose efflux from lysosome
reversible: false

metaR CO2tp
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
name: CO2 peroxisomal transport
reversible: true
kinetic law: MODEL1310110007#
fast: false
product: MODEL1310110007#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110007#_cbec1c35_1629_4d5a_a055_fb8d6a407c67
initial concentration: NaN
initial amount: NaN
constant: false
name: PIK3CA
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is: P42336
is encoded by: hsa:5290

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

metaR r1616
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110007#
is: SBO:0000185
reactant: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_ebdf9600_3aff_4567_9ab8_3a60410ae504
type: Species
initial concentration: NaN
has only substance units: false
is: B4DK61
name: ACOX1
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:51

metaR FUMAC
fast: false
type: Reaction
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.7.1.2
name: fumarylacetoacetase
is: SBO:0000176
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
product: MODEL1310110007#
reactant: MODEL1310110007#

metaM c226coa m
has only substance units: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
name: cervonyl coenzyme A
initial concentration: 1.0
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205479
initial amount: NaN
constant: false
is: C16169
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_c90f83a4_86a0_4911_bffc_20d4e073dd86
type: Species
has only substance units: false
is encoded by: hsa:117247
boundary condition: true
initial concentration: NaN
name: SLC16A10
is: SBO:0000252
is: Q8TF71
constant: false
initial amount: NaN

metaR MMCDm
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES:JLR mitochondrial isoform - NCD
is: SBO:0000176
reactant: MODEL1310110007#
is described by: ECO:0000212
modifier: MODEL1310110007#
reversible: false
type: Reaction
fast: false
product: MODEL1310110007#
name: Methylmalonyl-CoA decarboxylase, mitochondrial
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.1.1.9

http://identifiers.org/biomodels.db/MODEL1310110007#_19076c97_6951_4f9f_9089_eb6abe0e6474
initial amount: NaN
is encoded by: hsa:4719
constant: false
boundary condition: true
is: SBO:0000252
name: NDUFS1
type: Species
is: P28331
has only substance units: false
initial concentration: NaN

metaM duri c
is: SBO:0000247
type: Species
is: C00526
boundary condition: false
initial amount: NaN
name: Deoxyuridine
is: CHEBI:16450
has only substance units: false
constant: false
is: HMDB00012
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial concentration: 1.0

metaR r0309
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.22
fast: false
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
product: MODEL1310110007#
name: trans-Hexadec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction
modifier: MODEL1310110007#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_8a57c45f_d67a_4a87_9c67_4f2b8b6dd5b3
name: MTHFD2
has only substance units: false
boundary condition: true
is encoded by: hsa:10797
is: SBO:0000252
is: P13995
constant: false
initial concentration: NaN
initial amount: NaN
type: Species

metaR NDPK8n
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
reversible: true
product: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
type: Reaction
modifier: MODEL1310110007#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110007#_0baad4cb_16d5_4311_872f_49a8abe63841
name: HK3
is encoded by: hsa:3101
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species
is: P52790
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_b6accd36_b2b6_4d03_a83f_a33ce1822522
initial concentration: NaN
constant: false
is: O14495
is encoded by: hsa:8613
has only substance units: false
boundary condition: true
is: SBO:0000252
name: PPAP2B
initial amount: NaN
type: Species

metaR 3HBCOAHLm
product: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110007#
is: SBO:0000176
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
fast: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
reversible: false

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaR EHGLAT2m
product: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: false
is described by: ECO:0000304
modifier: MODEL1310110007#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110007#
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110007#_3363ecfc_0bdb_4e94_a7ae_3dc97fc7f5e1
is: SBO:0000252
type: Species
is: Q9H0N5
name: PCBD2
boundary condition: true
initial amount: NaN
is encoded by: hsa:84105
constant: false
has only substance units: false
initial concentration: NaN

metaR r1617
reactant: MODEL1310110007#
modifier: MODEL1310110007#
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110007#
type: Reaction
product: MODEL1310110007#

metaM dad 2 e
has only substance units: false
boundary condition: false
is: HMDB00101
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:17256
constant: false
name: 2-deoxyadenosine
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431

metaM apoC Lys m
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C6H13N2OX CHARGE: 0
is: HMDB00182
is: CHEBI:32551
constant: false
boundary condition: false
initial amount: NaN
name: Apocarboxylase (Lys residue)
initial concentration: 1.0

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

metaR r1561
is: SBO:0000185
reactant: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110007#
reversible: true
product: MODEL1310110007#
is described by: ECO:0000000

metaM glyc R m
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
constant: false
has only substance units: false
is: HMDB00139
name: D-glycerate
is: CHEBI:16659

metaR ALCD21 D
is version of: http://identifiers.org/ec-code/1.1.1.1
product: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
modifier: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
is: SBO:0000176
name: alcohol dehydrogenase (D-1,2-propanediol)
reversible: false
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.99.24
is described by: ECO:0000304

metaM udp c
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: C00015
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: UDP
is: HMDB00295
is: CHEBI:58223
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_6c53f978_e7fa_420e_8d54_50d8c8fa00bc
initial concentration: NaN
constant: false
is: SBO:0000252
name: SDHB
is: P21912
initial amount: NaN
is encoded by: hsa:6390
boundary condition: true
type: Species
has only substance units: false

metaR GLXO2p
is described by: ECO:0000269
kinetic law: MODEL1310110007#
type: Reaction
reversible: false
is: SBO:0000176
name: glyoxylate oxidase, peroxisomal
modifier: MODEL1310110007#
product: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.3.15
notes: GENE_ASSOCIATION: (54363.1) or (51179.2) or (51179.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.3.15 Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110007#_16137246_fb46_4acf_8724_3f71900b3145
has only substance units: false
is: Q96SL4
is encoded by: hsa:2882
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
name: GPX7
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_223ba9f3_903c_4c65_b692_9fd66e5796d3
name: HADH
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3033
is: Q16836
boundary condition: true
is: SBO:0000252
constant: false

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

metaM HC02217 c
has only substance units: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
type: Species
is: CHEBI:27647
boundary condition: false
name: prostaglandin-g2
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR NADS2
reversible: false
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.5.1
product: MODEL1310110007#
is described by: ECO:0000269
kinetic law: MODEL1310110007#
name: NAD synthase (glutamine-hydrolysing)
is: SBO:0000176
fast: false
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_16d0561f_e7a4_4093_bc8b_01cc3df52a17
initial concentration: NaN
is encoded by: hsa:2585
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: GALK2
type: Species
has only substance units: false

metaR AKR1D2
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.3.1.3
is: SBO:0000176
reversible: false
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
type: Reaction
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
kinetic law: MODEL1310110007#

metaR AMPDA
kinetic law: MODEL1310110007#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.6
modifier: MODEL1310110007#
name: Adenosine monophosphate deaminase
type: Reaction
reversible: false
reactant: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110007#_dcd0b673_d9ee_4889_9a4e_72ed5c9e5794
is: P35754
constant: false
is encoded by: hsa:2745
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: GLRX
initial concentration: NaN

MODEL1310110007
species: metaM C02528 c
species: metaM ppcoa c
reaction: metaR ALAR
reaction: metaR r1624
species: metaM Asn X Ser Thr l
species: metaM 2dodtricoa m
reaction: metaR ITCOALm
reaction: metaR r2196
reaction: metaR r1109
reaction: metaR r1260
reaction: metaR RE1836X
species: metaM cit c
reaction: metaR B3GALT3g
reaction: metaR r0426
reaction: metaR EX nadp LPAREN e RPAREN
reaction: metaR r0084
reaction: metaR r1592
reaction: metaR ABTti
species: metaM mmcoa R m
reaction: metaR r1639
species: metaM 5dhf m
species: metaM sgalside hs l
reaction: metaR FAOXC163C164Gm
species: metaM ncam c
reaction: metaR TXA2tr
species: metaM inost e
species: metaM h2o2 x
species: metaM HC02206 c
reaction: metaR C226CPT2
species: metaM clpn hs c
reaction: metaR FAOXC12C10x
reaction: metaR r2080
reaction: metaR PMTCOAtx
species: metaM thcholstoic c
reaction: metaR EX tsul LPAREN e RPAREN
species: metaM ha pre1 e
reaction: metaR r1650
reaction: metaR r0627
species: metaM amp m
reaction: metaR DAGt
species: metaM pristanal c
species: metaM Lpipecol x
reaction: metaR NACHEX10ly
reaction: metaR GLXtp
species: metaM hs deg1 l
species: metaM 4nph e
reaction: metaR r1665
reaction: metaR EX fru LPAREN e RPAREN
species: metaM 4mop e
species: metaM CE0233 c
species: metaM acac m
reaction: metaR CITt4 4
reaction: metaR PECGCHLe
reaction: metaR ME2m
reaction: metaR EX HC01444 LPAREN e RPAREN
species: metaM ocde9ecoa x
species: metaM HC02213 e
reaction: metaR r0733
reaction: metaR THBPT4ACAMDASE
species: metaM formcoa x
species: metaM bilirub c
species: metaM ksi deg18 l
species: metaM pnto R c
reaction: metaR PRPPS
reaction: metaR RE1254C
reaction: metaR PROSTGD2t
reaction: metaR r0122
reaction: metaR r0653
reaction: metaR SCP21cx
reaction: metaR r2090
species: metaM acmana c
species: metaM ksii core2 deg8 l
reaction: metaR DCSPTN1CPT1
reaction: metaR O2St
species: metaM ksi l
species: metaM hmgcoa m
reaction: metaR r1806
species: metaM Lcystin c
reaction: metaR RE2079R
reaction: metaR GLYCt

metaR r1618
modifier: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_f4e9d930_ac13_44c2_bee6_bf87de90a95c
type: Species
name: SLC25A20
is: SBO:0000252
initial concentration: NaN
is: O43772
is encoded by: hsa:788
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false

metaM 3aib D c
is: C03265
is: SBO:0000247
is: HMDB02299
initial concentration: 1.0
name: D-3-Amino-isobutanoate
has only substance units: false
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
boundary condition: false
initial amount: NaN
constant: false

metaR LEUPHELAT2tc
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM glu L e
constant: false
is: CHEBI:29985
name: L-glutamate(1-)
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00148
is: SBO:0000247

metaR GLUDxm
modifier: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
kinetic law: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.1.3
is described by: ECO:0000269
product: MODEL1310110007#
type: Reaction
fast: false
reversible: true
name: glutamate dehydrogenase (NAD) (mitochondrial)

metaM doldp L r
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C1080H1758O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
is: CHEBI:15750
has only substance units: false
initial amount: NaN
name: Dolichol diphosphate, human liver homolog
boundary condition: false

metaR MACOXO
notes: GENE_ASSOCIATION: (218.1) or (221.1) or (4129.1) or (222.1) or (220.1) SUBSYSTEM: Histidine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10344773 NOTES:SAB added 2 h to balance--not certain
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.4
type: Reaction
modifier: MODEL1310110007#
name: 3-Methylimidazole acetaldehyde:NAD+ oxidoreductase
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000269
fast: false

metaR r1560
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110007#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110007#
is: SBO:0000185
reversible: true

metaM acgam c
constant: false
is: HMDB00215
is: CHEBI:17411
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
name: N-acetyl-D-glucosamine
initial concentration: 1.0
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_52108fd3_7117_4f72_93a8_cfffdcfd3adf
type: Species
is encoded by: hsa:27068
boundary condition: true
initial amount: NaN
constant: false
name: PPA2
initial concentration: NaN
is: SBO:0000252
is: Q9H2U2
has only substance units: false

metaM f6p c
has only substance units: false
name: D-Fructose 6-phosphate
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3385
is: HMDB00124
is: CHEBI:57579
boundary condition: false
is: C00085
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_92cda778_7861_4c9f_ad08_e52367139bee
is: SBO:0000252
is encoded by: hsa:570
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
name: BAAT
is: Q14032
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_00c49b5e_1efa_4ddd_aa0b_5c461c6d47d5
is: SBO:0000252
is encoded by: hsa:83549
is: Q5JT09
initial concentration: NaN
boundary condition: true
constant: false
type: Species
name: UCK1
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_99877c52_1cf6_42ec_b9a3_adb7b1bcb4ad
initial amount: NaN
type: Species
is encoded by: hsa:23305
initial concentration: NaN
boundary condition: true
is: B2RB13
constant: false
has only substance units: false
name: ACSL6
is: SBO:0000252

metaR BHBt
type: Reaction
reversible: true
fast: false
name: (R)-3-Hydroxybutanoate transport via H+ symport
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_f81a2dfa_65e6_4f65_877f_912034e5db54
is: P20933
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:175
name: AGA
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_83cc40bb_d5f4_4a6b_9a3b_dc6c7e84823f
constant: false
initial amount: NaN
is encoded by: hsa:4121
is: SBO:0000252
is: P33908
boundary condition: true
has only substance units: false
name: MAN1A1
type: Species
initial concentration: NaN

metaR RE0958E
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1
reactant: MODEL1310110007#
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.17
product: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
modifier: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
name: RE0958
is described by: ECO:0000000

metaM tsul m
initial amount: NaN
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
boundary condition: false
name: thiosulfate(2-)
is: SBO:0000247
has only substance units: false
type: Species
constant: false
is: CHEBI:16094
initial concentration: 1.0
is: HMDB00257

metaR ECOAH9m
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
product: MODEL1310110007#
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
type: Reaction
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110007#_022b171a_a5f3_455f_a53a_ec94aa43f324
has only substance units: false
name: NDUFB10
boundary condition: true
type: Species
is: A8K761
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:4716

metaR NTP3e
is version of: http://identifiers.org/ec-code/3.6.1.6
name: nucleoside-triphosphatase (GTP)
type: Reaction
fast: false
modifier: MODEL1310110007#
reactant: MODEL1310110007#
reversible: false
product: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:

metaM xyl D e
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:15936
name: aldehydo-D-xylose
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110007#_5996e730_eed9_44ec_ac12_e003c7f3f9e7
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:AL525798
constant: false
has only substance units: false
initial concentration: NaN
name: _AL525798_1_c

http://identifiers.org/biomodels.db/MODEL1310110007#_6c107cf3_03e9_4101_b025_0ec29b5dc8f0
has only substance units: false
initial amount: NaN
name: PLCB2
is: SBO:0000252
is encoded by: hsa:5330
boundary condition: true
is: Q59F77
constant: false
type: Species
initial concentration: NaN

metaM man r
type: Species
is: CHEBI:16024
initial concentration: 1.0
initial amount: NaN
name: D-mannose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: HMDB00169
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM sphgn c
boundary condition: false
type: Species
is: HMDB00269
initial amount: NaN
is: SBO:0000247
is: CHEBI:57817
has only substance units: false
name: sphinganine(1+)
constant: false
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
initial concentration: 1.0

metaR FCOAH
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110007#
reversible: false
reactant: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
name: formyl coa hydrolase
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11341778,PMID:11591435 NOTES:Note - formcoa formula is uncharged - the correct is FACOAH2 w/ forcoa NJ

metaM tchola e
initial concentration: 1.0
notes: FORMULA: C26H45NO7S CHARGE: 0
name: taurocholic acid
type: Species
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00036
initial amount: NaN

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaM paps g
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: HMDB01134
type: Species
boundary condition: false
initial concentration: 1.0
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:58339

http://identifiers.org/biomodels.db/MODEL1310110007#_3d60ae70_025f_49ac_945e_5b766a121333
has only substance units: false
is encoded by: hsa:29968
name: PSAT1
constant: false
boundary condition: true
is: Q9Y617
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR r1619
modifier: MODEL1310110007#
product: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM 3oddcoa m
boundary condition: false
type: Species
is: HMDB03937
name: 3-Oxododecanoyl-CoA
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:27868
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
initial amount: NaN
has only substance units: false

metaM 3odcoa m
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
is: CHEBI:28528
is: SBO:0000247
name: 3-Oxodecanoyl-CoA
boundary condition: false
type: Species
is: HMDB03939
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_4d4b3199_5f2c_4b0a_8889_1bd92c13b707
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
name: HK1
is: P78542
is encoded by: hsa:3098
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_38f97df0_195d_404d_8a14_0cd75a4f5bfa
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:211
constant: false
type: Species
initial concentration: NaN
name: ALAS1
is: P13196
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_69528d17_f8c1_424d_b59e_f6385fe54513
initial concentration: NaN
is encoded by: hsa:686
boundary condition: true
has only substance units: false
name: BTD
initial amount: NaN
type: Species
is: P43251
constant: false
is: SBO:0000252

metaM gdp c
is: HMDB01201
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:58189
type: Species
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
name: GDP
is: C00035
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR DNDPt19m
is: SBO:0000185
name: dUDP transport via ATP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110007#
is described by: ECO:0000269
modifier: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
type: Reaction
reversible: false
product: MODEL1310110007#

metaM phyt e
constant: false
is: CHEBI:37257
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
name: phytanate
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
is: HMDB00801

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaR EX ksii core4 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 4-linked) exchange
type: Reaction

metaR r0181
is: SBO:0000176
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
reactant: MODEL1310110007#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_a48288e2_fac6_4654_a6dc_a8fde8f7cfa0
boundary condition: true
is: Q8WUD6
is: SBO:0000252
is encoded by: hsa:56994
type: Species
name: CHPT1
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR L LACt2r
fast: false
type: Reaction
is: SBO:0000185
name: L-lactate reversible transport via proton symport
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110007#
reversible: true
modifier: MODEL1310110007#
product: MODEL1310110007#

metaR CYTK3n
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
name: cytidylate kinase (dCMP,CTP),nuclear
product: MODEL1310110007#
reversible: true
kinetic law: MODEL1310110007#
type: Reaction
modifier: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

metaM tchola c
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
type: Species
is: HMDB00036
is: CHEBI:36257
name: taurocholic acid
is: SBO:0000247
constant: false
initial amount: NaN

metaR HSAT2ly
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
is described by: ECO:0000000
kinetic law: MODEL1310110007#
is: SBO:0000185
reactant: MODEL1310110007#
type: Reaction
name: heparan-glucosaminide N-acetyltransferase, lysosomal
fast: false
product: MODEL1310110007#

metaR r0647
kinetic law: MODEL1310110007#
name: Spontaneous reaction
fast: false
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
is: SBO:0000176
reactant: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
reversible: true

metaR PPDOy
type: Reaction
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
product: MODEL1310110007#
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.2
is described by: ECO:0000269
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.21
fast: false
kinetic law: MODEL1310110007#
reversible: false

metaR r1998
is: SBO:0000185
product: MODEL1310110007#
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110007#
modifier: MODEL1310110007#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110007#

metaM glu L c
name: L-glutamate(1-)
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00148
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial amount: NaN
is: CHEBI:29985

http://identifiers.org/biomodels.db/MODEL1310110007#_bd5f8875_816e_482d_b660_4c01db071179
is: SBO:0000252
is encoded by: hsa:221823
initial amount: NaN
boundary condition: true
name: PRPS1L1
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: P21108

metaR r1769
product: MODEL1310110007#
is: SBO:0000185
reversible: false
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#

metaR AICARte
product: MODEL1310110007#
reactant: MODEL1310110007#
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
fast: false
reversible: true
is described by: ECO:0000134
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110007#

metaM dhcrm hs c
is: SBO:0000247
name: dihydroceramide
boundary condition: false
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
is: CHEBI:31488
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_74dcdb3a_4a8b_471b_89a6_e164723b0d91
boundary condition: true
is encoded by: hsa:9061
type: Species
constant: false
is: SBO:0000252
is: O43252
name: PAPSS1
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_100d667c_a390_45ce_99a5_d3cfcd76afec
initial amount: NaN
type: Species
is encoded by: hsa:206
initial concentration: NaN
name: _206_1_c
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM 4mop m
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
name: 4-methyl-2-oxopentanoate
is: HMDB00695
constant: false
is: CHEBI:17865
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_14c29b86_77d6_41ef_b03b_84b0125fb56c
type: Species
name: GSTZ1
is encoded by: hsa:2954
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is: A6NED0

http://identifiers.org/biomodels.db/MODEL1310110007#_af0b6b40_2dc3_4a72_8fc0_ae91d68603c8
has only substance units: false
is: Q99714
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3028
type: Species
boundary condition: true
constant: false
initial amount: NaN
name: HSD17B10

metaR BPNT
fast: false
reactant: MODEL1310110007#
product: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.3.7
is described by: ECO:0000269
name: 3',5'-bisphosphate nucleotidase
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
reversible: false
kinetic law: MODEL1310110007#

metaM udp g
name: UDP(3-)
boundary condition: false
is: SBO:0000247
is: HMDB00295
initial amount: NaN
is: CHEBI:58223
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial concentration: 1.0
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_4f20e440_e6db_4538_9413_d9217c77ee28
name: ALDH1B1
is: P30837
is encoded by: hsa:219
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_c6d88277_0c9c_4464_a43c_29ef62dbd0e6
is: P15907
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6480
name: ST6GAL1
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_845a16b6_22ae_44f9_8398_1a8579267b69
boundary condition: true
type: Species
constant: false
is encoded by: hsa:AI620219
name: _AI620219_1_m
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR NTD5m
fast: false
notes: GENE_ASSOCIATION: (56953.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
name: 5'-nucleotidase (dTMP), mitochondrial
modifier: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.5
reversible: false
kinetic law: MODEL1310110007#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110007#_2164b41b_0936_4b5d_b62b_21137dd107d7
boundary condition: true
is encoded by: hsa:54511
type: Species
is: Q9NT06
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: HMGCLL1

http://identifiers.org/biomodels.db/MODEL1310110007#_77dad025_2400_4f40_a542_8915bf37254f
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: Q16853
name: AOC3
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8639

http://identifiers.org/biomodels.db/MODEL1310110007#_5a1c51f1_3892_4e59_91ca_b936a16b609b
is: P48736
name: PIK3CG
constant: false
is encoded by: hsa:5294
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR TAGt
reactant: MODEL1310110007#
fast: false
is: SBO:0000185
name: triacylglycerol transport
is described by: ECO:0000000
product: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110007#

metaR GGH 7DHFe
modifier: MODEL1310110007#
product: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
name: Gamma-glutamyl hydrolase (7DHF), extracellular
kinetic law: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9

http://identifiers.org/biomodels.db/MODEL1310110007#_4ede4489_8b6a_4da4_9227_6e6c16da6df4
initial amount: NaN
type: Species
is: P38571
boundary condition: true
is: SBO:0000252
name: LIPA
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:3988

metaM pep c
initial concentration: 1.0
is: SBO:0000247
is: HMDB00263
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
initial amount: NaN
has only substance units: false
constant: false
is: C00074
boundary condition: false
type: Species
is: CHEBI:18021
name: Phosphoenolpyruvate

metaR r0881
name: Active transport
reactant: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
type: Reaction
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
fast: false

metaM fmn c
initial amount: NaN
name: FMN
boundary condition: false
type: Species
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
has only substance units: false
is: C00061
is: HMDB01520
constant: false
initial concentration: 1.0
is: CHEBI:58210
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_c016d5b0_f55d_4ce8_9b82_a5de03c0be1e
initial concentration: NaN
has only substance units: false
constant: false
is: Q9BXS1
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:91734
boundary condition: true
name: IDI2

http://identifiers.org/biomodels.db/MODEL1310110007#_720db6a1_8695_4070_8641_e818c66875ff
type: Species
is encoded by: hsa:X63359
name: _X63359_1_c
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true

metaR S6TASE24ly
is: SBO:0000176
type: Reaction
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
product: MODEL1310110007#

metaR S6TASE17ly
kinetic law: MODEL1310110007#
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110007#
reversible: true

metaR PHEACGLNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
product: MODEL1310110007#
reversible: true
name: PHEACGLN extracellular transport via diffusion
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110007#_ca33f630_a712_4f8c_99ef_2397a9996c28
boundary condition: true
constant: false
is encoded by: hsa:AI971036
name: _AI971036_1_c
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_dc8354fc_79dd_40d0_9164_13cff140cb38
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
name: PLCB1
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:23236

metaR MANt4
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reversible: true
reactant: MODEL1310110007#
name: D-mannose transport via sodium cotransport
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#
fast: false

metaR ACETONEt2m
type: Reaction
name: acetone mitochondrial transport via proton symport
reactant: MODEL1310110007#
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#

metaR UMPK2n
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
fast: false
name: UMP kinase (CTP),nuclear
reactant: MODEL1310110007#
modifier: MODEL1310110007#
reversible: true
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110007#
type: Reaction

metaM andrstandn r
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
is: CHEBI:15994
is: SBO:0000247
is: HMDB00899
type: Species
boundary condition: false
constant: false
name: 5alpha-androstane-3,17-dione

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_3326eaa7_d01a_449b_8276_be51f8abf944
name: AK3
is encoded by: hsa:50808
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: E7ET30

http://identifiers.org/biomodels.db/MODEL1310110007#_5c4b4148_92c6_41fd_82d2_8e5a4494807e
has part: P36957
name: DLD:DLST:OGDH:PDHX
boundary condition: true
is encoded by: hsa:1738
has part: P09622
is encoded by: hsa:8050
is encoded by: hsa:4967
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000297
constant: false
has part: B4E3E9
is encoded by: hsa:1743
initial amount: NaN
has part: O00330

http://identifiers.org/biomodels.db/MODEL1310110007#_aee35f59_a171_4fd6_a5be_0b2dae65fd9c
is encoded by: hsa:55512
initial concentration: NaN
has only substance units: false
constant: false
name: SMPD3
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is: A8K0T6

metaR CYSSNAT5tc
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM dhea r
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
name: 3beta-hydroxyandrost-5-en-17-one
is: CHEBI:28689
is: HMDB00077
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227

metaM ppa e
is: HMDB00237
initial amount: NaN
type: Species
initial concentration: 1.0
name: propionate
is: CHEBI:17272
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false

metaR OMPDC
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
fast: false
reactant: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000269
reversible: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110007#
name: orotidine-5'-phosphate decarboxylase
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.4.2.10

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaM xoldiolone r
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
constant: false
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB02197
is: SBO:0000247
is: CHEBI:28477

metaM txa2 c
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
initial concentration: 1.0
constant: false
is: HMDB01452
boundary condition: false
has only substance units: false
is: CHEBI:57445
initial amount: NaN
name: thromboxane A2(1-)
is: SBO:0000247

metaR PYRt2r
reversible: true
fast: false
name: pyruvate reversible transport via proton symport
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
is described by: ECO:0000269
modifier: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#

metaR r1567
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
fast: false
product: MODEL1310110007#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110007#_41447916_5220_4ba6_9590_c5bdd7c60319
is: SBO:0000252
type: Species
name: NME7
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:29922
is: Q9Y5B8
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_cdd89a02_77d1_4334_9cd2_51113291a671
is: SBO:0000252
type: Species
initial concentration: NaN
is: D9HTE9
name: SLC25A1
has only substance units: false
initial amount: NaN
is encoded by: hsa:6576
boundary condition: true
constant: false

metaM paps c
is: HMDB01134
type: Species
is: CHEBI:58339
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
initial concentration: 1.0
has only substance units: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate

metaR D3AIBTm
kinetic law: MODEL1310110007#
product: MODEL1310110007#
fast: false
is described by: ECO:0000000
reversible: true
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
reactant: MODEL1310110007#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM

metaR r0644
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110007#
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
product: MODEL1310110007#
is: SBO:0000176
reactant: MODEL1310110007#
is described by: ECO:0000000
type: Reaction

metaR NDP3ex
is described by: ECO:0000269
name: nucleoside-diphosphatase (GDP), extracellular
reversible: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
reactant: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.6.1.6
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_37856970_a2a5_4eaa_9a1f_e60f5f797dc9
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5286
is: SBO:0000252
is: O00443
constant: false
boundary condition: true
name: PIK3C2A
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_5ff30a5d_7c86_4ba8_96ec_2dd45ab9ff02
name: ATP2B2
constant: false
is: Q4J699
is encoded by: hsa:491
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM arab L e
is: SBO:0000247
is: CHEBI:30849
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0
type: Species
initial amount: NaN
name: L-arabinose
constant: false
is: HMDB00646

metaM peamn c
is: HMDB12275
is: CHEBI:225237
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
boundary condition: false
is: SBO:0000247
name: 2-phenylethanaminium
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_ed59362b_280f_4a4c_b99e_743302175b78
name: DPM1
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: O60762
is encoded by: hsa:8813
boundary condition: true
initial concentration: NaN

metaR KSItly
product: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
reversible: false
is described by: ECO:0000000
name: keratan sulfate I transport, extracellular to lysosome
kinetic law: MODEL1310110007#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaM pheacgln e
is: HMDB06344
is: SBO:0000247
has only substance units: false
is: CHEBI:58310
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false

metaM ins e
type: Species
constant: false
initial amount: NaN
name: Inosine
is: SBO:0000247
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
has only substance units: false
is: CHEBI:17596
initial concentration: 1.0
is: HMDB00195
boundary condition: false
is: C00294

metaM udp n
is: SBO:0000247
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial concentration: 1.0
boundary condition: false
is: CHEBI:58223
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00295
name: UDP(3-)

metaR GGH 7DHFl
type: Reaction
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (7DHF), lysosomal
product: MODEL1310110007#
reactant: MODEL1310110007#

metaR r1566
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#

metaM coa c
initial concentration: 1.0
is: C00010
name: Coenzyme A
initial amount: NaN
boundary condition: false
is: HMDB01423
is: CHEBI:3312
type: Species
is: SBO:0000247
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_1897c474_a06a_4d2c_a850_7245002b9f01
type: Species
constant: false
is encoded by: hsa:1109
is: SBO:0000252
is: P17516
name: AKR1C4
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_7bbd1d00_2a57_4a25_afe1_a3947e2853a6
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:3251
is: SBO:0000252
initial concentration: NaN
name: HPRT1
is: P00492
initial amount: NaN

metaM HC01444 e
constant: false
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:15754
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
initial concentration: 1.0
initial amount: NaN
name: Galactosylglycerol
is: SBO:0000247

metaR DCK1n
is version of: http://identifiers.org/ec-code/2.7.1.74
name: Deoxycytidine kinase, nuclear (ATP)
type: Reaction
fast: false
modifier: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)

metaR FAOXC2252053m
is: SBO:0000176
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
is described by: ECO:0000000
type: Reaction
reversible: false
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110007#

metaM 4abutn c
name: 4-Aminobutanal
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: C00555
constant: false
is: HMDB01080
is: CHEBI:58264

http://identifiers.org/biomodels.db/MODEL1310110007#_478f9b11_8a0f_4422_8db6_f38298ebcfae
initial amount: NaN
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is: Q15661
is: SBO:0000252
name: TPSAB1
has only substance units: false
is encoded by: hsa:7177

metaM k c
constant: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
name: potassium
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:29103
is: C00238
initial amount: NaN
is: HMDB00586
has only substance units: false
type: Species

metaR NRPPHRt4 2 r
is described by: ECO:0000269
product: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
name: Norepinephrine reversible transport in via sodium symport (1:2)
reactant: MODEL1310110007#
is: SBO:0000185
fast: false

metaM k e
initial concentration: 1.0
is: SBO:0000247
name: potassium
is: CHEBI:29103
boundary condition: false
initial amount: NaN
is: C00238
type: Species
constant: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: HMDB00586
has only substance units: false

metaR GGH 7THFe
reactant: MODEL1310110007#
modifier: MODEL1310110007#
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110007#
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (7THF), extracellular
is: SBO:0000176
type: Reaction
product: MODEL1310110007#

metaM xyl D c
is: CHEBI:15936
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
type: Species
name: aldehydo-D-xylose
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM mi14p c
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
is: CHEBI:58282
is: HMDB00968
is: SBO:0000247
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220

metaM txa2 e
name: thromboxane A2(1-)
type: Species
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: HMDB01452
initial concentration: 1.0
boundary condition: false
is: CHEBI:57445
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM HC02210 e
name: prostaglandin-d3
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:34939
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false

metaR NACHEX27ly
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110007#
is: SBO:0000176

metaM amet m
type: Species
is: C00019
is: HMDB01185
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
has only substance units: false
name: S-Adenosyl-L-methionine
constant: false
is: CHEBI:15414
is: SBO:0000247
boundary condition: false

metaR r2506
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110007#
product: MODEL1310110007#
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110007#

metaR MM5cg
reactant: MODEL1310110007#
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.113
product: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
modifier: MODEL1310110007#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_736d137d_3b8f_4dd1_973c_41ccc7aec03f
name: CPT2
has only substance units: false
is encoded by: hsa:1376
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: P23786

metaR r1569
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
reactant: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110007#
reversible: true

metaM CE5101 m
is: SBO:0000247
constant: false
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
type: Species
is: CHEBI:57795
boundary condition: false
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
has only substance units: false
initial concentration: 1.0

metaM ksi deg1 l
type: Species
constant: false
is: HMDB00174
name: keratan sulfate I, degradation product 1
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18287

metaM acgam l
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
name: N-acetyl-D-glucosamine
is: HMDB00215
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:17411
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_cfda029a_1282_4815_afd8_7442a4580258
initial amount: NaN
is encoded by: hsa:27124
name: INPP5J
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaM hpyr c
has only substance units: false
constant: false
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
is: SBO:0000247
boundary condition: false
name: 3-hydroxypyruvate
is: HMDB01352
type: Species
is: CHEBI:17180
initial concentration: 1.0
initial amount: NaN

metaR GTHPm
reversible: true
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
is version of: http://identifiers.org/ec-code/1.11.1.15
product: MODEL1310110007#
modifier: MODEL1310110007#
name: glutathione peroxidase, mitochondria
is version of: http://identifiers.org/ec-code/1.11.1.12
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110007#_26afc398_b7eb_47cd_8f83_72c374d7a5e3
has only substance units: false
constant: false
name: DLD
type: Species
is: P09622
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1738
initial amount: NaN
is: SBO:0000252

metaR GALNTg
reactant: MODEL1310110007#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.41
type: Reaction
fast: false
product: MODEL1310110007#
name: GalNAc transferase, Golgi apparatus
is described by: ECO:0000000
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#

metaR RE3367E
is version of: http://identifiers.org/ec-code/1.4.3.22
reactant: MODEL1310110007#
product: MODEL1310110007#
modifier: MODEL1310110007#
name: RE3367
is: SBO:0000176
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110007#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110007#_55092bf5_7eee_49cd_a2d9_6330b4249c4a
boundary condition: true
type: Species
initial concentration: NaN
is: O43674
is: SBO:0000252
is encoded by: hsa:4711
has only substance units: false
name: NDUFB5
constant: false
initial amount: NaN

metaM gcald c
has only substance units: false
is: CHEBI:17071
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB03344
type: Species
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
constant: false
initial concentration: 1.0
name: glycolaldehyde

metaM ins c
type: Species
name: Inosine
constant: false
has only substance units: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00195
is: CHEBI:17596
is: C00294

http://identifiers.org/biomodels.db/MODEL1310110007#_29b85941_629e_4da7_978b_84d1258eda4c
initial concentration: NaN
is encoded by: hsa:56623
has only substance units: false
is: SBO:0000252
is: Q9NRR6
type: Species
name: INPP5E
boundary condition: true
initial amount: NaN
constant: false

metaM pheacgln c
initial amount: NaN
constant: false
has only substance units: false
is: HMDB06344
is: SBO:0000247
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
is: CHEBI:58310
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
boundary condition: false
type: Species
initial concentration: 1.0

metaR GTHS
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110007#
name: glutathione synthetase
is version of: http://identifiers.org/ec-code/6.3.2.3
is: SBO:0000176
fast: false
reactant: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (2937.1) SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM arab L c
is: HMDB00646
type: Species
is: CHEBI:30849
initial concentration: 1.0
constant: false
has only substance units: false
name: L-arabinose
notes: FORMULA: C5H10O5 CHARGE: 0
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaM pchol hs m
is: CHEBI:16110
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
initial concentration: 1.0
constant: false
is: SBO:0000247
name: Phosphatidylcholine
has only substance units: false

metaM phyt c
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
is: CHEBI:37257
is: HMDB00801
constant: false
boundary condition: false
name: phytanate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_08357fbd_9ba7_4cd4_8e82_9a945f095460
has part: P38117
has only substance units: false
constant: false
name: ETFA:ETFB
is: SBO:0000297
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:2109
initial amount: NaN

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaM 44mzym r
is: CHEBI:18364
is: SBO:0000247
name: 14-demethyllanosterol
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01286
type: Species
boundary condition: false
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108

metaR r1568
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110007#
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110007#
product: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false

metaM apoC Lys c
name: Apocarboxylase (Lys residue)
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00182
notes: FORMULA: C6H13N2OX CHARGE: 0
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:32551

metaM c226coa x
is: SBO:0000247
is: C16169
boundary condition: false
has only substance units: false
type: Species
name: cervonyl coenzyme A
initial amount: NaN
constant: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205479

metaM udp l
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:58223
has only substance units: false
type: Species
constant: false
name: UDP(3-)
initial amount: NaN
is: HMDB00295

metaM ksi deg36 l
is: HMDB00143
is: CHEBI:12936
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
initial amount: NaN
is: SBO:0000247
name: keratan sulfate I, degradation product 36

http://identifiers.org/biomodels.db/MODEL1310110007#_5a0441c6_c5a0_4115_ab8c_8c28d427733f
is encoded by: hsa:6319
initial amount: NaN
name: SCD
has only substance units: false
initial concentration: NaN
type: Species
is: O00767
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_c7e02aa7_56c0_49f8_8eaa_36fcd4575ad7
has only substance units: false
initial amount: NaN
is: Q9H845
constant: false
type: Species
initial concentration: NaN
name: ACAD9
is encoded by: hsa:28976
is: SBO:0000252
boundary condition: true

metaR r0287
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reversible: false
kinetic law: MODEL1310110007#
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
modifier: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_85b662e2_36f4_40e7_b9cc_3022580939e3
is: Q92947
name: GCDH
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:2639
constant: false

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_739ec12a_f471_43c2_9b39_a2e83b7b3e07
name: PNP
is: P00491
is encoded by: hsa:4860
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_6653cb1e_b10e_4ac2_8e6c_5de7e6d3a882
is encoded by: hsa:8706
initial amount: NaN
type: Species
name: B3GALNT1
constant: false
initial concentration: NaN
boundary condition: true
is: Q49AT3
is: SBO:0000252
has only substance units: false

metaR CEPTC
type: Reaction
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/2.7.8.2
is: SBO:0000176
modifier: MODEL1310110007#
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
name: choline phosphotransferase
product: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (10390.1) or (56994.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR r2507
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110007#
reversible: true
reactant: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false
name: Utilized transport

metaR ALCD21 L
product: MODEL1310110007#
is described by: ECO:0000304
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.99.24
reversible: false
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
name: alcohol dehydrogenase (L-1,2-propanediol)
fast: false
is: SBO:0000176
modifier: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.1
reactant: MODEL1310110007#

metaR 34HPPte
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110007#
name: Transport of 3-(4-hydroxyphenyl)pyruvate
is described by: ECO:0000134
product: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_8eedba4a_5218_4a22_9d0c_fb7d85900324
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: _728226_1_m
has only substance units: false
is encoded by: hsa:728226
type: Species
initial concentration: NaN

metaR r1650
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110007#
modifier: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110007#
reversible: true

metaM ctp n
is: SBO:0000247
boundary condition: false
constant: false
name: CTP(4-)
is: HMDB00082
is: CHEBI:37563
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaR GLYSARPEPT1tc
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Glycylsarcosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine, renal cells and brain.
type: Reaction

metaM c226coa c
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/47205479
type: Species
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
name: cervonyl coenzyme A
is: C16169

metaR ADCim
fast: false
product: MODEL1310110007#
name: Acetoacetate decarboxylation (irreversible), mitochondrial
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
type: Reaction
is described by: ECO:0000000

metaR FOLR2
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
is: SBO:0000176
fast: false
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.5.1.3
product: MODEL1310110007#
type: Reaction
reversible: false
name: folate reductase
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000254

metaR 2AMADPTm
product: MODEL1310110007#
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
modifier: MODEL1310110007#
fast: false
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_c53a5492_3452_4d36_8b57_1ef68eca6db0
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: Q59EA4
is encoded by: hsa:5337
is: SBO:0000252
name: PLD1

metaR DADA
product: MODEL1310110007#
reversible: false
is described by: ECO:0000269
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
type: Reaction
modifier: MODEL1310110007#
reactant: MODEL1310110007#
name: Deoxyadenosine deaminase
is version of: http://identifiers.org/ec-code/3.5.4.4
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_4c7436da_421e_4b6b_a1c6_ca7fa28cfef5
is: P48067
initial amount: NaN
has only substance units: false
is encoded by: hsa:6536
type: Species
is: SBO:0000252
name: SLC6A9
boundary condition: true
constant: false
initial concentration: NaN

metaR RE3005M
name: RE3005
type: Reaction
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110007#
product: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110007#_cb0e28da_87d0_4557_9bfb_ac128b57cf19
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:249
is: SBO:0000252
name: ALPL
is: B7Z4Y6
initial concentration: NaN
boundary condition: true
type: Species

metaR APOC LYS BTNPm
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reversible: false
product: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#
is: SBO:0000176
fast: false
reactant: MODEL1310110007#
name: proteolysis of apoC-Lys-btn, mitochondrial

metaR r0909
is described by: ECO:0000000
fast: false
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
reversible: true
is: SBO:0000185
name: Transport reaction
kinetic law: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#

metaM xylt e
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
type: Species
initial concentration: 1.0
initial amount: NaN
name: xylitol
is: SBO:0000247
is: HMDB02917
boundary condition: false
is: CHEBI:17151
constant: false
has only substance units: false

metaM man6p c
is: CHEBI:17369
type: Species
constant: false
is: HMDB01078
boundary condition: false
initial concentration: 1.0
name: D-Mannose 6-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_2768be1a_ef2d_4825_961f_c408bee654c5
name: SLC13A4
has only substance units: false
constant: false
type: Species
boundary condition: true
is: Q9UKG4
is encoded by: hsa:26266
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM hs deg16 l
has only substance units: false
name: heparan sulfate, degradation product 16
is: CHEBI:21338
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
boundary condition: false
is: HMDB02704
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_f11d7dab_9776_4960_afcf_b479be333a22
constant: false
is encoded by: hsa:34
boundary condition: true
name: ACADM
type: Species
is: SBO:0000252
has only substance units: false
is: P11310
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_7e171ed9_f90a_48a3_ab14_a590698bff43
has only substance units: false
constant: false
name: MECR
is: Q9BV79
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:51102
initial concentration: NaN
initial amount: NaN

metaM leuktrF4 e
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:27491
name: leukotriene F4
has only substance units: false
is: HMDB06465
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1

metaM urcan c
initial amount: NaN
name: Urocanate
has only substance units: false
is: HMDB00301
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
type: Species
constant: false
is: CHEBI:17771
is: SBO:0000247
boundary condition: false
is: C00785
initial concentration: 1.0

metaR AHCYSte
type: Reaction
reversible: true
product: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
name: Transport of S-adenosyl-L-homocysteine
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110007#
is described by: ECO:0000134

metaM vitd3 e
is: HMDB00876
name: calciol
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:28940
is: SBO:0000247

metaR r0973
name: Facilitated diffusion
fast: false
kinetic law: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110007#

metaM pail35p hs c
has only substance units: false
type: Species
constant: false
is: CHEBI:57923
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_6db85deb_0907_491b_b5cd_29788b783d10
is: Q8IX04
has only substance units: false
is encoded by: hsa:55293
name: UEVLD
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_e1ec2f1b_8ba2_49b5_9097_d2451da08836
type: Species
is: E7ET32
is: SBO:0000252
is encoded by: hsa:2592
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: GALT

metaM dhea c
initial amount: NaN
has only substance units: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
name: 3beta-hydroxyandrost-5-en-17-one
is: SBO:0000247
is: CHEBI:28689
constant: false
is: HMDB00077
type: Species
boundary condition: false
initial concentration: 1.0

metaR GLCNACASE3ly
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.50
reversible: false
is described by: ECO:0000000
product: MODEL1310110007#
is: SBO:0000176
name: alpha-N-acetylglucosaminidase, lysosomal
modifier: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction

metaR RE1804M
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110007#
reversible: true
fast: false
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.15
name: RE1804
kinetic law: MODEL1310110007#
type: Reaction
product: MODEL1310110007#

metaR r0666
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.2
modifier: MODEL1310110007#
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
reversible: true
reactant: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1

metaR PIter
kinetic law: MODEL1310110007#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
reactant: MODEL1310110007#
reversible: true
fast: false
name: phosphate transport, endoplasmic reticulum
modifier: MODEL1310110007#
is described by: ECO:0000212
product: MODEL1310110007#

metaM CE2420 m
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: HMDB11123
is: CHEBI:28387
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110007#_2749a6a8_ebaa_4d1d_8cb7_192910208bc9
constant: false
initial concentration: NaN
is encoded by: hsa:T83654
is: SBO:0000252
name: _T83654_1_m
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN

metaM bamppald c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
initial amount: NaN
constant: false
name: beta-Aminopropion aldehyde
is: HMDB01106
is: http://identifiers.org/pubchem.compound/7975
initial concentration: 1.0
boundary condition: false
type: Species
is: C05665

metaM biocyt c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/7886
boundary condition: false
is: C05552
initial amount: NaN
is: HMDB03134
name: Biocytin
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
constant: false
type: Species

metaM ocdcea e
name: octadecenoate (n-C18:1)
is: HMDB00207
initial concentration: 1.0
constant: false
notes: FORMULA: C18H33O2 CHARGE: -1
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: C00712
type: Species
is: CHEBI:0
has only substance units: false

metaR BTNt4i
type: Reaction
modifier: MODEL1310110007#
name: Biotin uptake (antiport)
fast: false
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
reactant: MODEL1310110007#
is described by: ECO:0000269

metaR NADN
name: NAD nucleosidase
product: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000176
fast: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.2.2.5 Confidence Level: 2 AUTHORS: PMID:8382685 NOTES:
type: Reaction
reversible: false

metaM dmnoncrn m
is: HMDB06202
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
name: 4,8 dimethylnonanoyl carnitine

metaM CE2705 c
type: Species
initial amount: NaN
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:36781
name: quinonoid dihydrobiopterin
constant: false

metaM Rtotal2 c
is: SBO:0000247
is: C00055
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:60377
notes: FORMULA: CO2FULLR2 CHARGE: -1
name: R total 2 position
constant: false
is: HMDB00095

metaR APOCF
is described by: ECO:0000000
reversible: false
product: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000176
name: Apocarboxylase formation
type: Reaction
fast: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism

http://identifiers.org/biomodels.db/MODEL1310110007#_fca7da32_8812_478a_81a2_ad1cf425494a
is: O75414
type: Species
constant: false
initial amount: NaN
boundary condition: true
name: NME6
initial concentration: NaN
is encoded by: hsa:10201
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_a078bb96_a465_4780_9a0a_34d97fc21265
has only substance units: false
type: Species
is: P22352
is: SBO:0000252
is encoded by: hsa:2878
name: GPX3
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false

metaR r0908
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110007#
reversible: true
product: MODEL1310110007#
type: Reaction
name: Postulated transport reaction

metaR CYTK1
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP)
product: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#

metaR C4STMO1r
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
is described by: ECO:0000000
is: SBO:0000176
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.14.13.72
product: MODEL1310110007#
fast: false
type: Reaction
reversible: false
modifier: MODEL1310110007#

metaM HC01610 e
is: SBO:0000247
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
initial amount: NaN
type: Species
name: CoproporphyrinogenI
initial concentration: 1.0
constant: false
is: CHEBI:28607
has only substance units: false
boundary condition: false

metaR AHCYStd
kinetic law: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
type: Reaction
reversible: true
product: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000134
name: diffusion of S-Adenosyl-L-homocysteine

metaM 20ahchsterol m
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
is: HMDB06283
is: CHEBI:1296
initial concentration: 1.0
boundary condition: false
name: 20-hydroxycholesterol
is: SBO:0000247
constant: false
type: Species

metaR PROSTGE2t
reversible: true
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
fast: false
is: SBO:0000185
kinetic law: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reactant: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000269

metaM hxcoa m
has only substance units: false
type: Species
name: Hexanoyl-CoA (n-C6:0CoA)
is: HMDB06522
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4

metaR ACN13ACNGALGBSIDEtg
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110007#
name: acn13acngalgbside hs intracellular transport
reactant: MODEL1310110007#
type: Reaction
is: SBO:0000185

metaR r1925
name: Y+LAT2 Utilized transport
product: MODEL1310110007#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110007#
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM lgnc e
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
constant: false
type: Species
is: HMDB02003
initial amount: NaN
name: lignocerate
is: CHEBI:31014
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_e1570bee_0049_4e3b_96a5_630131101dea
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: GALNT10
is encoded by: hsa:55568
boundary condition: true
initial concentration: NaN

metaR r1817
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110007#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
reversible: false
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110007#_1fbd89ec_9138_41bc_8aa1_34ca4e341086
type: Species
is: SBO:0000252
name: ADSL
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:158

metaR CYTK2
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110007#
modifier: MODEL1310110007#
fast: false
product: MODEL1310110007#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
name: cytidylate kinase (dCMP)

metaR TSULt4 3
fast: false
kinetic law: MODEL1310110007#
is: SBO:0000185
reactant: MODEL1310110007#
reversible: true
type: Reaction
name: thiosulfate transport via sodium symport
is described by: ECO:0000269
modifier: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD

metaM ctp m
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:37563
is: SBO:0000247
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
name: CTP(4-)
constant: false
initial concentration: 1.0
is: HMDB00082
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_7e362100_361f_42ee_8788_0f13acf24dfb
constant: false
is: Q8IWX5
is: SBO:0000252
name: SGPP2
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:130367
boundary condition: true
has only substance units: false
type: Species

metaM vitd3 c
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
initial amount: NaN
constant: false
is: CHEBI:28940
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00876
type: Species
has only substance units: false
name: calciol

metaR 3MOX4HOXPGALDOX NADP
is described by: ECO:0000304
reactant: MODEL1310110007#
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
type: Reaction
reversible: true
is: SBO:0000176
product: MODEL1310110007#

metaM atp n
has only substance units: false
is: HMDB00538
is: CHEBI:57299
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: ATP(3-)
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
boundary condition: false
is: SBO:0000247

metaM ocdcea c
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: octadecenoate (n-C18:1)
notes: FORMULA: C18H33O2 CHARGE: -1
initial amount: NaN
is: CHEBI:0
is: C00712
is: HMDB00207

metaM Rtotal e
name: R total
initial amount: NaN
is: HMDB00244
initial concentration: 1.0
notes: FORMULA: CO2FULLR CHARGE: -1
is: C00255
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:3554
constant: false
boundary condition: false

metaR ARACHDt2
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
fast: false
product: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
reactant: MODEL1310110007#
type: Reaction

metaR RE0383C
is described by: ECO:0000000
kinetic law: MODEL1310110007#
reversible: true
reactant: MODEL1310110007#
product: MODEL1310110007#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.2
modifier: MODEL1310110007#
is: SBO:0000176
name: RE0383

http://identifiers.org/biomodels.db/MODEL1310110007#_7ef85ff2_f25f_489b_9844_715ef24df2d7
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaM lnlc e
is: SBO:0000247
boundary condition: false
name: linoleate
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:30245
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
type: Species
is: HMDB00673
initial amount: NaN

metaM Rtotal2 e
boundary condition: false
constant: false
is: C00255
has only substance units: false
is: CHEBI:3554
initial amount: NaN
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: SBO:0000247
is: HMDB00244
initial concentration: 1.0
type: Species
name: R total 2 position

http://identifiers.org/biomodels.db/MODEL1310110007#_1854a093_0103_421d_b68b_971703926cd6
name: ALG3
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:10195

metaM 13dampp c
is: SBO:0000247
is: CHEBI:57484
has only substance units: false
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
initial amount: NaN
type: Species
is: HMDB00002
boundary condition: false
constant: false
name: trimethylenediaminium
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_a18eaa68_ba6f_45c0_9dbd_0390dc77eb04
is: P05091
name: ALDH2
is encoded by: hsa:217
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false

metaM retinol c
name: retinol
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:50211
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00305
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3

metaM atp m
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:57299
name: ATP(4-)
is: HMDB00538
boundary condition: false
constant: false
initial amount: NaN
is: C00002
type: Species

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_62fa82d8_e647_4afa_8fc7_82fda57eee70
constant: false
is: SBO:0000252
type: Species
is: P50440
initial concentration: NaN
name: GATM
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:2628

metaM formcoa c
name: formyl-CoA(4-)
is: CHEBI:57376
has only substance units: false
type: Species
is: HMDB03419
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
is: SBO:0000247

metaR EX creat LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Creatine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_8014961d_85f0_49d5_9bd6_c007df93c8b0
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:4514
name: COX3
type: Species
is: SBO:0000252
is: P00414
constant: false

metaR r2371
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
fast: false

metaR r2057
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: false
product: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110007#
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_d875d3db_a464_485f_a4ed_8ca1f457defb
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q8NEM3
is encoded by: hsa:9194
constant: false
name: SLC16A7
type: Species
initial concentration: NaN

metaM gdp e
type: Species
constant: false
initial concentration: 1.0
is: HMDB01201
boundary condition: false
name: GDP(3-)
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
has only substance units: false
is: CHEBI:58189

metaR CYTK2n
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reversible: true
is: SBO:0000176
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is described by: ECO:0000269
name: cytidylate kinase (dCMP),nuclear
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110007#

metaM dgchol c
name: glycochenodeoxycholate
is: HMDB00637
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial concentration: 1.0
is: CHEBI:36252
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_870f7163_94aa_471d_9e58_a1f08a610333
type: Species
boundary condition: true
is encoded by: hsa:AV717590
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: _AV717590_1_m

metaM 34dhmald m
is: C05577
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/7903
type: Species
name: 3,4-Dihydroxymandelaldehyde
is: SBO:0000247
has only substance units: false
is: HMDB06242

http://identifiers.org/biomodels.db/MODEL1310110007#_ef054124_279e_44f0_a120_0fa29d72d06d
initial concentration: NaN
is encoded by: hsa:23533
initial amount: NaN
boundary condition: true
type: Species
name: PIK3R5
is: Q8WYR1
constant: false
has only substance units: false
is: SBO:0000252

metaM 3ddecdicoa m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: HMDB03952
constant: false
type: Species
boundary condition: false
is: C05280
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: 3,6-dodecadienoylcoa
initial concentration: 1.0

metaM arachd c
is: HMDB01043
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: arachidonate
is: SBO:0000247
is: CHEBI:32395
constant: false
has only substance units: false

metaR 4NPHSFte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
kinetic law: MODEL1310110007#
fast: false
is described by: ECO:0000000
product: MODEL1310110007#
name: xenobiotic transport
reversible: true
reactant: MODEL1310110007#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110007#_a4ab4b27_fb47_4258_8076_b808a4acdaa0
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is: O75610
is encoded by: hsa:10637
initial concentration: NaN
type: Species
name: LEFTY1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_0ca653c3_5bcc_4562_860c_d28413be4b04
has only substance units: false
name: ALG8
is encoded by: hsa:79053
is: SBO:0000252
initial amount: NaN
is: A6NDW6
boundary condition: true
type: Species
constant: false
initial concentration: NaN

metaM fald l
initial amount: NaN
constant: false
is: HMDB01426
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
type: Species
boundary condition: false
is: CHEBI:16842
name: formaldehyde

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

metaR PHYCBOXL
name: L-Phenylalanine carboxy-lyase
is described by: ECO:0000212
product: MODEL1310110007#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
reversible: false
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.1.1.28
modifier: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#

metaR GLNtm
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
reversible: false
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
reactant: MODEL1310110007#
name: L-glutamine transport via electroneutral transporter
kinetic law: MODEL1310110007#

metaR TREHe
modifier: MODEL1310110007#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
name: alpha,alpha-trehalase
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
is version of: http://identifiers.org/ec-code/3.2.1.28
fast: false
type: Reaction
product: MODEL1310110007#

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaR GULN3D
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
fast: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110007#
name: L-gulonate 3-dehydrogenase

http://identifiers.org/biomodels.db/MODEL1310110007#_4ccb8a7d_55d5_45d0_aaf1_1c4738f269bc
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:223
initial amount: NaN
is: P49189
has only substance units: false
type: Species
name: ALDH9A1

http://identifiers.org/biomodels.db/MODEL1310110007#_dd957be3_5347_4947_846a_591f86b9f0c4
name: PDE1C
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q8NB10
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:5137
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_28b46f48_4cec_49af_a6ed_97ed916f5f26
is encoded by: hsa:765
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
name: CA6
initial concentration: NaN
is: Q5FC00
boundary condition: true

metaM dutp c
is: C00460
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: CHEBI:17625
name: dUTP
initial amount: NaN
is: HMDB01191
is: SBO:0000247
type: Species
boundary condition: false

metaR r1926
modifier: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110007#
reversible: false

metaM ile L m
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
name: L-isoleucine
is: CHEBI:17191
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
is: HMDB00172

metaR CRNt
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
fast: false
name: L-carnitine reversible transport
modifier: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000269
reversible: true
type: Reaction
product: MODEL1310110007#
kinetic law: MODEL1310110007#

metaM ksii core2 deg6 l
has only substance units: false
notes: FORMULA: C44H72N4O33SX CHARGE: -1
name: keratan sulfate II (core 2-linked), degradation product 6
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:12936
is: HMDB00143
initial concentration: 1.0
constant: false
initial amount: NaN

metaR r1700
modifier: MODEL1310110007#
reversible: false
product: MODEL1310110007#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
name: Y+LAT2 Utilized transport
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM ascb L e
is: CHEBI:38290
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
name: L-ascorbate
type: Species
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
boundary condition: false
is: HMDB00044
has only substance units: false

metaR EX oxa LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

metaR r0974
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reversible: true
name: Active transport
type: Reaction

metaR CLOXAtex2
is described by: ECO:0000304
reversible: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
product: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
name: chloride transport via oxalate countertransport (2:1)
is: SBO:0000185
fast: false
modifier: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_bb6c0dca_19f6_408e_a183_7be8eead210b
type: Species
is: SBO:0000252
name: GLO1
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:2739
is: Q04760
initial concentration: NaN

metaM leuktrF4 c
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
name: leukotriene F4
initial amount: NaN
constant: false
is: CHEBI:27491
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB06465

http://identifiers.org/biomodels.db/MODEL1310110007#_3b84ef29_58f1_4125_8313_03b08379964b
has only substance units: false
initial amount: NaN
boundary condition: true
name: _HG2846_HT2983_1_m
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:HG2846-HT2983

metaR DADNt4
reactant: MODEL1310110007#
reversible: true
fast: false
kinetic law: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
product: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
name: deoxyadenosine transport via diffusion

metaM retinol e
name: retinol
constant: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00305
has only substance units: false
type: Species
is: CHEBI:50211

metaR PSDm hs
reactant: MODEL1310110007#
name: Phosphatidylserine decarboxylase
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
reversible: false
kinetic law: MODEL1310110007#
is described by: ECO:0000269
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.65
modifier: MODEL1310110007#
type: Reaction
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_44a110c7_0a66_4549_9e53_806269e3cbfa
has only substance units: false
boundary condition: true
is encoded by: hsa:1103
constant: false
type: Species
initial amount: NaN
name: CHAT
is: SBO:0000252
initial concentration: NaN
is: Q6LEN5

metaM CE1936 e
type: Species
notes: FORMULA: C10H22N2O2 CHARGE: 2 INCHI: InChI=1/C10H20N2O2/c13-9-3-7-11-5-1-2-6-12-8-4-10-14/h9-12H,1-8H2/p+2 EHMN_ABBREVIATION: CE1936
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
name: spermine dialdehyde
is: CHEBI:36781
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_f8c72831_47d4_40da_809d_ebc2ac31547e
type: Species
initial concentration: NaN
is: P50135
name: HNMT
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:3176

http://identifiers.org/biomodels.db/MODEL1310110007#_3e4f67b1_42da_4f75_9060_d832a4d291aa
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
name: UPB1
constant: false
is encoded by: hsa:51733
is: B3KNC1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_698f9254_682f_41ef_9165_2f32430922e7
name: SLC26A6
is encoded by: hsa:65010
initial concentration: NaN
initial amount: NaN
constant: false
is: Q548A7
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

metaM gdp g
is: HMDB01201
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: GDP(3-)
initial amount: NaN
is: SBO:0000247
is: CHEBI:58189
constant: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
type: Species

metaR RE3074X
notes: GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:11060359,PMID:11356164 NOTES:IT - fixed proton
type: Reaction
is: SBO:0000176
name: RE3074
reversible: true
kinetic law: MODEL1310110007#
product: MODEL1310110007#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110007#

metaM cytd m
initial amount: NaN
is: CHEBI:17562
is: HMDB00089
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: SBO:0000247
has only substance units: false
type: Species
name: cytidine
boundary condition: false
initial concentration: 1.0
constant: false

metaM sgalside hs c
initial amount: NaN
is: HMDB03406
is: SBO:0000247
name: sulfatide galactocerebroside
constant: false
type: Species
is: CHEBI:16523
initial concentration: 1.0
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
boundary condition: false
has only substance units: false

metaM xylt c
constant: false
boundary condition: false
type: Species
initial amount: NaN
name: xylitol
is: SBO:0000247
is: HMDB02917
has only substance units: false
initial concentration: 1.0
is: CHEBI:17151
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379

metaR THRD L
name: L-threonine deaminase
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 4.3.1.19 Confidence Level: 4 AUTHORS: PMID:12361482 NOTES:Previous EC number: 4.2.1.16. New EC number 4.3.1.19. Can't enter this....
is described by: ECO:0000269
reversible: false
is: SBO:0000176
type: Reaction
product: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.3.1.17
modifier: MODEL1310110007#

metaR ABTD
reactant: MODEL1310110007#
type: Reaction
fast: false
is described by: ECO:0000000
name: L-arabinitol 4-dehydrogenase
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176

metaR APOC LYS BTNP
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110007#
fast: false
type: Reaction
product: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#
name: proteolysis of apoC-Lys-btn
is described by: ECO:0000000

metaM h2o c
type: Species
boundary condition: false
is: CHEBI:3303
has only substance units: false
constant: false
name: H2O
is: C00001
is: HMDB02111
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_c2313ce6_aed4_414d_af55_4283b1f8a4e7
is: SBO:0000252
name: CHAT
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:1103
type: Species
is: P28329
has only substance units: false

metaM arachd e
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:32395
name: arachidonate
boundary condition: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
type: Species
is: SBO:0000247
is: HMDB01043

metaM dhdascb c
type: Species
has only substance units: false
is: HMDB01264
name: dehydroascorbide(1-)
boundary condition: false
initial amount: NaN
is: CHEBI:58070
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
is: SBO:0000247
constant: false
initial concentration: 1.0

metaM dgchol e
is: HMDB00637
constant: false
type: Species
initial amount: NaN
name: glycochenodeoxycholate
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: CHEBI:36252
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM arachcrn m
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: arachidyl carnitine
type: Species
is: HMDB06460
constant: false

metaM HC01397 m
name: (S)-3-Hydroxyhexadecanoyl-CoA
is: CHEBI:27402
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR r0660
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reversible: true
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
modifier: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_9bf4ba59_69b8_483e_8610_2b9505ad58d7
type: Species
is encoded by: hsa:8790
name: FPGT
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: O14772
boundary condition: true
initial concentration: NaN
constant: false

metaR IZPN
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110007#
product: MODEL1310110007#
reversible: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Imidazolonepropionase

http://identifiers.org/biomodels.db/MODEL1310110007#_cf9b6256_cacb_4ee4_bd5c_e4ec78591e30
initial concentration: NaN
constant: false
has only substance units: false
name: SLC5A11
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is: Q8WWX8
is encoded by: hsa:115584

http://identifiers.org/biomodels.db/MODEL1310110007#_d4af30c9_862a_4700_8dc2_3bc8248c460c
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:56606
constant: false
type: Species
name: SLC2A9
is: Q9NRM0
boundary condition: true
initial amount: NaN

metaM pe hs m
boundary condition: false
is: CHEBI:16038
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
name: phosphatidylethanolamine
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350

metaM m5mpdol L r
initial amount: NaN
is: SBO:0000247
is: CHEBI:37634
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false
notes: FORMULA: C1600H2628N20O470P20 CHARGE: -20

metaR L LACt4r
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
type: Reaction
product: MODEL1310110007#
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: L-lactate reversible transport via sodium symport
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#

metaR DUDPtn
type: Reaction
product: MODEL1310110007#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
reactant: MODEL1310110007#
name: dUDP nuclear transport
reversible: true

metaR RE2999M
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110007#
product: MODEL1310110007#
modifier: MODEL1310110007#
name: RE2999
fast: false
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.3.3.8
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110007#_882782cb_5d67_4edf_a3aa_c26de3246556
name: SLCO1B1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
is: Q9Y6L6
is encoded by: hsa:10599

http://identifiers.org/biomodels.db/MODEL1310110007#_ec6d7d45_27f7_4d7f_94d3_fe00e9cf8a0f
constant: false
is encoded by: hsa:1103
boundary condition: true
type: Species
is: Q6LEN6
initial concentration: NaN
name: CHAT
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM oh1 c
is: HMDB01039
type: Species
is: SBO:0000247
notes: FORMULA: HO CHARGE: -1
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: C01328
boundary condition: false
name: hydroxide ion

metaR EX txa2 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thromboxane A2 exchange
type: Reaction

metaR r2375
reversible: true
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110007#
fast: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110007#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110007#_4054584a_5b9d_4de2_ab88_9ffebc210449
initial amount: NaN
is: SBO:0000252
is: Q8NEB9
is encoded by: hsa:5289
name: PIK3C3
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species

metaR GLYt4
type: Reaction
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB irreversible
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000269
fast: false
name: glycine transport via sodium symport
reactant: MODEL1310110007#
reversible: false
is: SBO:0000185
modifier: MODEL1310110007#

metaM HC01407 m
name: (S)-Hydroxyhexanoyl-CoA
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: CHEBI:28276
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_fe204703_429e_4996_bf3a_6ddf78458d6e
initial amount: NaN
type: Species
is: P13073
initial concentration: NaN
is encoded by: hsa:1327
is: SBO:0000252
name: COX4I1
has only substance units: false
boundary condition: true
constant: false

metaM bhb e
is: SBO:0000247
constant: false
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
name: (R)-3-hydroxybutyrate
initial amount: NaN
is: HMDB00011
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: CHEBI:10983

metaR DM anth
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR r0753
reversible: true
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
is: SBO:0000176
modifier: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
fast: false

metaM fe2 e
initial concentration: 1.0
name: Fe2+
is: CHEBI:29033
type: Species
has only substance units: false
constant: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
boundary condition: false
is: C00023
is: SBO:0000247
is: HMDB00692
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_9a61ea40_663c_41f5_a03a_beb969576c41
boundary condition: true
name: DUT
is: P33316
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:1854
type: Species
initial amount: NaN

metaM na1 r
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
is: CHEBI:29101
initial concentration: 1.0
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
is: HMDB00588
name: sodium(1+)
has only substance units: false

metaR 34DHPLACOX NADP
reversible: true
kinetic law: MODEL1310110007#
product: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110007#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (222.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
type: Reaction
is: SBO:0000176
name: 3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase
fast: false

metaM xoltriol m
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
is: CHEBI:16496
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
is: HMDB01457
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_fbbf4ba3_9ba0_4f3d_9605_38deb79ab503
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
name: ALDOC
is: P09972
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:230

metaR r0552
reversible: true
fast: false
modifier: MODEL1310110007#
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.5.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
kinetic law: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
product: MODEL1310110007#

metaM ascb L c
is: HMDB00044
type: Species
name: L-ascorbate
is: CHEBI:38290
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR r1658
is described by: ECO:0000000
product: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
modifier: MODEL1310110007#
reactant: MODEL1310110007#

metaR MG3er
type: Reaction
reversible: false
reactant: MODEL1310110007#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110007#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
product: MODEL1310110007#
is described by: ECO:0000000

metaR r1811
type: Reaction
product: MODEL1310110007#
fast: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
is: SBO:0000185
reversible: false

metaR SIAASE3ly
name: sialidase, lysosomal
reversible: false
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
product: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR HEX1
name: hexokinase (D-glucose:ATP)
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.1.1
is described by: ECO:0000134
reactant: MODEL1310110007#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.2
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
fast: false
product: MODEL1310110007#
type: Reaction

metaM fum c
boundary condition: false
is: SBO:0000247
is: CHEBI:29806
is: C00122
is: HMDB00134
initial concentration: 1.0
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
type: Species
constant: false
name: Fumarate
initial amount: NaN
has only substance units: false

metaM akg c
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: SBO:0000247
boundary condition: false
name: 2-Oxoglutarate
constant: false
is: HMDB00208
has only substance units: false
initial concentration: 1.0
is: C00026
initial amount: NaN
type: Species
is: CHEBI:16810

metaR ATP1ter
kinetic law: MODEL1310110007#
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
product: MODEL1310110007#
name: ADP/ATP transporter, endoplasmic reticulum
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_c1b97de9_c98a_42d2_9e0b_1e722bd01a57
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1606
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
name: DGKA
boundary condition: true
is: P23743

metaM maltttr e
is: HMDB01296
initial amount: NaN
name: Maltotetraose
type: Species
is: C02052
is: SBO:0000247
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
is: http://identifiers.org/pubchem.compound/5141
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false

metaR r2374
type: Reaction
reversible: true
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110007#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110007#
fast: false

metaR NACHEX21ly
kinetic law: MODEL1310110007#
type: Reaction
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
reactant: MODEL1310110007#
is: SBO:0000176
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_27706895_b482_471c_a7d3_a22a302ef49a
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P16260
initial amount: NaN
constant: false
name: SLC25A16
type: Species
is encoded by: hsa:8034

metaM thp2c x
boundary condition: false
has only substance units: false
type: Species
constant: false
is: CHEBI:16987
initial amount: NaN
is: SBO:0000247
name: 1-piperideine-6-carboxylate
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
is: HMDB12130
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_4b60cbe0_5215_43f5_a01f_683155d7a1a3
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: XDH
type: Species
is: P47989
initial concentration: NaN
is encoded by: hsa:7498
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_73d17d0d_9ed3_4001_bd05_e71b4e0b8f7b
name: ATP10A
type: Species
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: O60312
is encoded by: hsa:57194

metaM pac c
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: phenylacetate
type: Species
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
is: HMDB00209
initial concentration: 1.0
constant: false
is: CHEBI:18401
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_400e1ce8_0268_42cb_b839_9452f5a982b8
initial amount: NaN
constant: false
type: Species
is: Q9NUB1
initial concentration: NaN
boundary condition: true
name: ACSS1
is encoded by: hsa:84532
has only substance units: false
is: SBO:0000252

metaR r0752
reactant: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
modifier: MODEL1310110007#
product: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is: SBO:0000176

metaR MG1er
modifier: MODEL1310110007#
product: MODEL1310110007#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.106
is described by: ECO:0000000
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_f4761424_d08b_44af_8a5e_9d866a5db0d7
name: GUK1
initial amount: NaN
is encoded by: hsa:2987
type: Species
has only substance units: false
is: Q16774
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true

metaM 3hpp m
is: SBO:0000247
has only substance units: false
is: CHEBI:16510
initial amount: NaN
name: 3-hydroxypropionate
constant: false
is: HMDB00700
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013

metaR r0553
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is described by: ECO:0000000
is: SBO:0000176
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
kinetic law: MODEL1310110007#
fast: false
type: Reaction
reactant: MODEL1310110007#
product: MODEL1310110007#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_4842a961_95c7_483b_a95d_2a373c9f561f
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: PIK3R1
is encoded by: hsa:5295
has only substance units: false
initial concentration: NaN
is: B3KT19
type: Species
constant: false

metaM h2o e
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
initial concentration: 1.0
type: Species
has only substance units: false
name: H2O
is: HMDB02111
constant: false
is: C00001
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM phyt x
is: HMDB00801
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:37257
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
name: phytanate
constant: false

metaR r1657
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110007#
fast: false
modifier: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_37894e2e_b43c_4931_8b6c_b6a1bc8bc6e9
is: Q8N0X4
initial amount: NaN
is encoded by: hsa:171425
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
name: CLYBL
constant: false

metaR HEX4
modifier: MODEL1310110007#
is described by: ECO:0000304
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.1.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
is version of: http://identifiers.org/ec-code/2.7.1.2
type: Reaction
product: MODEL1310110007#
name: hexokinase (D-mannose:ATP)
reversible: false
reactant: MODEL1310110007#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_9cb6a3a2_f385_4299_bf9c_e008ccfc0225
name: VNN2
is: O95498
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:8875

metaM mi34p c
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C04063
is: CHEBI:28858
boundary condition: false
constant: false
initial amount: NaN
is: HMDB06235
is: SBO:0000247
name: 1D-myo-Inositol 3,4-bisphosphate
has only substance units: false
type: Species
initial concentration: 1.0

metaM dudp m
is: HMDB01000
is: SBO:0000247
initial amount: NaN
type: Species
name: dUDP(3-)
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: CHEBI:60471
boundary condition: false

metaR RE1804C
fast: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reversible: true
reactant: MODEL1310110007#
name: RE1804
product: MODEL1310110007#
type: Reaction

metaR r2055
reversible: false
is: SBO:0000185
product: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaM sgalside hs g
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58343
is: SBO:0000247
type: Species
boundary condition: false
constant: false
name: sulfatide galactocerebroside
has only substance units: false
is: HMDB00061
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1

metaM bhb c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: CHEBI:10983
name: (R)-3-hydroxybutyrate
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00011
constant: false
type: Species

metaR r2373
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
reversible: true
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110007#
fast: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_b630ea7b_0c15_4c37_87eb_54b986f44847
is encoded by: hsa:4125
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: MAN2B1
is: O00754
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_c01b4831_99db_4565_a91a_d47873e3a0ce
constant: false
boundary condition: true
initial amount: NaN
is: A8DPS7
name: PAFAH1B2
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5049

metaR A MANASEly
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.24
name: alpha-mannosidase, lysosomal
is described by: ECO:0000000
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
fast: false
reversible: false
reactant: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_63ae6e8f_020a_4a7f_81e4_d898cb6728db
has only substance units: false
constant: false
is encoded by: hsa:10449
name: ACAA2
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: P42765
initial amount: NaN

metaR r1656
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
modifier: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#

metaM HC01397 x
type: Species
has only substance units: false
name: (S)-3-Hydroxyhexadecanoyl-CoA
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:27402

http://identifiers.org/biomodels.db/MODEL1310110007#_c2926103_7978_4c23_a7a7_614f627d6a42
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:2645
is: SBO:0000252
is: Q53Y25
type: Species
name: GCK
has only substance units: false
initial concentration: NaN

metaM fe2 c
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
initial amount: NaN
is: C00023
is: HMDB00692
is: SBO:0000247
name: Fe2+
is: CHEBI:29033
has only substance units: false

metaM sphs1p e
is: CHEBI:60119
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
boundary condition: false
name: sphingosine 1-phosphate(1-)
type: Species
is: HMDB00277
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_f9855c97_601e_4bbf_b92d_6490d5591066
has only substance units: false
is encoded by: hsa:54344
constant: false
name: DPM3
boundary condition: true
is: Q9P2X0
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species

metaR HPYRDC
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.1.40 Confidence Level: 2 AUTHORS: PMID:3778681 NOTES:NCD
reactant: MODEL1310110007#
name: hydroxypyruvate decarboxylase
product: MODEL1310110007#
is: SBO:0000176
reversible: false

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_00d4e331_f2a5_4dfa_b990_d7556631cda5
boundary condition: true
name: ADH1B
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:125
is: P00325
initial amount: NaN
constant: false

metaM dudp n
initial concentration: 1.0
is: CHEBI:60471
boundary condition: false
is: HMDB01000
has only substance units: false
constant: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: SBO:0000247
initial amount: NaN
type: Species
name: dUDP(3-)

metaM oretn c
notes: FORMULA: C20H27O3 CHARGE: -1 INCHI: InChI=1/C20H26O3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21)11-12-20(17,4)5/h6-10,13H,11-12H2,1-5H3,(H,22,23)/p-1
is: SBO:0000247
boundary condition: false
is: CHEBI:35291
initial concentration: 1.0
has only substance units: false
name: 4-oxo-retinoic acid
type: Species
is: HMDB01852
constant: false
initial amount: NaN

metaM uacgam c
is: HMDB00290
constant: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: CHEBI:57705
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043

http://identifiers.org/biomodels.db/MODEL1310110007#_879987c5_e03f_42f2_8f78_a248944cb76f
is encoded by: hsa:3632
name: INPP5A
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q14642
boundary condition: true
constant: false
initial amount: NaN

metaR r2372
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaM fucgalgbside hs g
type: Species
is: HMDB00174
constant: false
notes: FORMULA: C56H99N2O31FULLRCO CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: CHEBI:18287
is: SBO:0000247
name: fucosyl galactosylgloboside
initial amount: NaN
has only substance units: false

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaR GGLUCT
name: gamma-glutamylcyclotransferase
is version of: http://identifiers.org/ec-code/2.3.2.4
fast: false
modifier: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
kinetic law: MODEL1310110007#

metaR r1418
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
product: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
is described by: ECO:0000000
reversible: true
is: SBO:0000176

metaR SUCCTD
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaM asp L m
type: Species
name: L-aspartate(1-)
is: CHEBI:29991
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
constant: false
is: SBO:0000247
is: HMDB00191
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_631ff0e5_886f_498c_913a_a7765f569b9b
is: SBO:0000252
name: CPT1B
is encoded by: hsa:1375
has only substance units: false
type: Species
is: B7Z5T8
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false

metaR FPGS5m
is: SBO:0000176
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
name: folylpolyglutamate synthetase (DHF), mitochondrial
reactant: MODEL1310110007#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/6.3.2.17
product: MODEL1310110007#
modifier: MODEL1310110007#
reversible: false
type: Reaction
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_bd326a1e_3978_4094_8bfd_6a7807ce70cc
initial concentration: NaN
name: TPH2
is: SBO:0000252
has only substance units: false
is: Q8IWU9
is encoded by: hsa:121278
boundary condition: true
constant: false
type: Species
initial amount: NaN

metaM h2o g
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: water
is: CHEBI:15377
type: Species
initial amount: NaN
is: HMDB02111
constant: false

metaR r1655
is described by: ECO:0000000
product: MODEL1310110007#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110007#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110007#
modifier: MODEL1310110007#

metaM coa x
is: HMDB01423
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:57287
initial amount: NaN
is: C00010
name: Coenzyme A
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
type: Species
has only substance units: false

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_28ab0f17_2703_470b_bff0_f6b1a6811cfd
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
name: COX7A2
constant: false
is: H0UI06
boundary condition: true
is encoded by: hsa:1347
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_a67870bd_096e_477e_bfe1_5be9a9ea1212
constant: false
is encoded by: hsa:3948
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
name: LDHC
initial concentration: NaN
has only substance units: false

metaR r1610
product: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_e796413c_1e8a_4997_93f8_d31a58714c9f
is: P30038
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: ALDH4A1
type: Species
boundary condition: true
constant: false
is encoded by: hsa:8659

metaR r2379
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
product: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_7b13f19a_94da_446c_8690_271e9baf379f
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
name: PLCD1
is: P51178
boundary condition: true
constant: false
is encoded by: hsa:5333

metaR ACN13ACNGALGBSIDEte
reactant: MODEL1310110007#
name: acn13acngalgbside hs transport
is described by: ECO:0000000
product: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_ea9a7276_3317_4ba7_9870_67c3d3b6aa9e
is encoded by: hsa:29920
name: PYCR2
is: Q96C36
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false

metaM lgnc c
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: lignocerate
is: CHEBI:31014
boundary condition: false
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
constant: false
is: HMDB02003
initial concentration: 1.0

metaR GCALDD
reversible: false
type: Reaction
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110007#
is described by: ECO:0000304
fast: false
reactant: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#
name: Glycolaldehyde dehydrogenase

metaM tymsf e
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
is: HMDB06409
type: Species
name: Tyramine O-sulfate
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_a205b439_7b80_4850_acb1_9ed8f62cac67
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaM nh4 c
type: Species
has only substance units: false
is: C01342
boundary condition: false
name: Ammonium
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: SBO:0000247
is: CHEBI:28938
initial amount: NaN
is: HMDB00051
constant: false
initial concentration: 1.0

metaM dtdp n
is: SBO:0000247
is: CHEBI:58369
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB01274
has only substance units: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial amount: NaN
type: Species

metaR r1654
kinetic law: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110007#
modifier: MODEL1310110007#
fast: false

metaR r0556
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
reversible: true
reactant: MODEL1310110007#
product: MODEL1310110007#
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.14.19.1

metaM gdp m
initial concentration: 1.0
is: HMDB01201
is: C00035
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: CHEBI:58189
name: GDP
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_81539fd3_f115_4b7b_b2a0_1b747533798c
name: SLC12A3
constant: false
is encoded by: hsa:6559
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is: P55017

metaM ile L c
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
is: HMDB00172
boundary condition: false
name: L-isoleucine
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: CHEBI:17191

metaM glu L m
type: Species
initial concentration: 1.0
is: HMDB00148
has only substance units: false
boundary condition: false
is: CHEBI:29985
name: L-glutamate(1-)
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
constant: false
initial amount: NaN
is: SBO:0000247

metaM hs deg11 l
initial amount: NaN
is: HMDB00868
type: Species
notes: FORMULA: C55H81N3O67S7 CHARGE: -8
boundary condition: false
name: heparan sulfate, degradation product 11
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:57737

metaM xan c
name: Xanthine
initial amount: NaN
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
boundary condition: false
is: SBO:0000247
type: Species
is: C00385
has only substance units: false
is: HMDB00292
constant: false
initial concentration: 1.0
is: CHEBI:17712

metaM arachd l
has only substance units: false
is: CHEBI:32395
constant: false
initial concentration: 1.0
name: arachidonate
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
boundary condition: false
type: Species
is: HMDB01043

metaM atp e
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00538
initial concentration: 1.0
has only substance units: false
is: C00002
is: CHEBI:57299
name: ATP(4-)
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_d70d764c_163b_4771_9aa7_4de221e64ee6
is encoded by: hsa:79053
constant: false
initial concentration: NaN
has only substance units: false
name: ALG8
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species

metaR AMETt2m
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
fast: false
product: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_9f73bfdc_2da8_462f_957a_de12374be31c
is encoded by: hsa:953
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q86VV3
initial amount: NaN
has only substance units: false
name: ENTPD1
constant: false

metaM met L e
has only substance units: false
is: CHEBI:16643
is: HMDB00696
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: L-methionine

metaM succ m
type: Species
boundary condition: false
constant: false
name: Succinate
has only substance units: false
initial concentration: 1.0
is: CHEBI:30031
is: HMDB00254
is: C00042
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042

metaR URIt5le
is: SBO:0000185
type: Reaction
is described by: ECO:0000134
reversible: false
name: uridine transport in via sodium symport (1:2)
modifier: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR HACD9m
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
modifier: MODEL1310110007#
reversible: true
product: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid

http://identifiers.org/biomodels.db/MODEL1310110007#_33d10380_eac3_422c_b44b_8a252b9bb1ab
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: CDIPT
type: Species
boundary condition: true
constant: false
is: O14735
is encoded by: hsa:10423

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaM sphs1p c
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:60119
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
constant: false
is: HMDB00277
initial concentration: 1.0
initial amount: NaN
name: sphingosine 1-phosphate(1-)

metaR r2378
is: SBO:0000185
reactant: MODEL1310110007#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
is described by: ECO:0000000
product: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
type: Reaction

metaR r0557
is described by: ECO:0000000
modifier: MODEL1310110007#
is: SBO:0000176
name: Glutaryl-CoA:dihydrolipoamide S-succinyltransferase Lysine degradation EC:2.3.1.61
type: Reaction
reversible: false
reactant: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:9620315 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110007#_69567d0e_1250_474e_b60c_3d022695a642
is encoded by: hsa:2805
type: Species
constant: false
is: SBO:0000252
name: GOT1
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P17174

metaR r1653
is described by: ECO:0000000
modifier: MODEL1310110007#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110007#_4a8b838f_0471_4db6_b091_9c4ee92e7645
name: DECR1
is: Q16698
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:1666
initial amount: NaN
is: SBO:0000252
constant: false

metaM cytd c
is: CHEBI:17562
constant: false
has only substance units: false
initial amount: NaN
is: C00475
is: HMDB00089
type: Species
initial concentration: 1.0
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
name: Cytidine
is: SBO:0000247
boundary condition: false

metaR ATPtx
type: Reaction
reactant: MODEL1310110007#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
product: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
name: ATP transporter, peroxisomal
reversible: true

metaM gdp n
is: CHEBI:58189
name: GDP(3-)
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB01201
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: SBO:0000247
boundary condition: false

metaM coa r
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial amount: NaN
type: Species
has only substance units: false
is: HMDB01423
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:57287
initial concentration: 1.0
is: C00010
name: Coenzyme A

metaM adrncoa x
constant: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: SBO:0000247
name: adrenyl coenzyme A
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205480
initial amount: NaN
boundary condition: false
is: C16170
initial concentration: 1.0

metaR ARACHt
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
is: SBO:0000185
name: fatty acid transport via diffusion
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaR r0381
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
reversible: true
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:

metaM pe hs c
has only substance units: false
constant: false
is: HMDB02704
notes: FORMULA: CHARGE: 0
is: SBO:0000247
name: pe_hs[c]
initial amount: NaN
is: CHEBI:21338
boundary condition: false
initial concentration: 1.0
type: Species

metaR MAN6PI
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/5.3.1.8
product: MODEL1310110007#
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110007#
name: mannose-6-phosphate isomerase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110007#_0c53b242_7751_437e_99d6_d765a0ecc0f5
name: GPD1
has only substance units: false
boundary condition: true
initial concentration: NaN
is: F8W1L5
is encoded by: hsa:2819
constant: false
is: SBO:0000252
initial amount: NaN
type: Species

metaM fucgalgbside hs e
is: CHEBI:15824
constant: false
is: SBO:0000247
has only substance units: false
name: fucosyl galactosylgloboside
is: C00095
boundary condition: false
is: HMDB00660
notes: FORMULA: C56H99N2O31FULLRCO CHARGE: 0
initial amount: NaN
initial concentration: 1.0
type: Species

metaR r2377
reversible: true
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
product: MODEL1310110007#
type: Reaction

metaR NADHtpu
is: SBO:0000185
kinetic law: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
fast: false
reactant: MODEL1310110007#
reversible: false
type: Reaction
name: NADH transporter, peroxisome
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_3bcb3fa5_e851_4b60_bfe6_56d495beb05c
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q86YT5
is encoded by: hsa:284111
name: SLC13A5
type: Species
initial amount: NaN
constant: false

metaM cdp m
initial amount: NaN
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:58069
name: CDP(3-)
type: Species
boundary condition: false
is: HMDB01546
initial concentration: 1.0

metaM doco13ecoa c
boundary condition: false
type: Species
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/24892791
name: 13-docosenoylcoa
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaM arachcrn c
has only substance units: false
boundary condition: false
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
is: SBO:0000247
type: Species
is: HMDB06460
name: arachidyl carnitine
initial amount: NaN
initial concentration: 1.0
constant: false

metaM retinal 11 cis c
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:16066
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
name: 11-cis-retinal
is: HMDB02152
type: Species
initial amount: NaN

metaR r1708
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110007#
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction
product: MODEL1310110007#
modifier: MODEL1310110007#
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110007#

metaM oh1 e
initial amount: NaN
is: HMDB01039
type: Species
has only substance units: false
is: C01328
name: hydroxide ion
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: HO CHARGE: -1

metaR NCNt
is: SBO:0000185
reactant: MODEL1310110007#
type: Reaction
modifier: MODEL1310110007#
name: Na+/Ca2+-NH4+ exchange
reversible: true
is described by: ECO:0000269
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
fast: false
kinetic law: MODEL1310110007#

metaR RE3567C
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
product: MODEL1310110007#
reactant: MODEL1310110007#
reversible: true
kinetic law: MODEL1310110007#
name: RE3567
fast: false
type: Reaction
is: SBO:0000176

metaM tymsf c
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB06409
type: Species
has only substance units: false
name: Tyramine O-sulfate
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
is: SBO:0000247
initial amount: NaN

metaR r1652
reactant: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110007#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
modifier: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#

metaM udpg r
type: Species
constant: false
has only substance units: false
is: HMDB00286
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
initial amount: NaN
is: CHEBI:58367
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029

http://identifiers.org/biomodels.db/MODEL1310110007#_cd1a6ea7_69ba_4831_92f5_f1788d33cfd6
initial amount: NaN
type: Species
is: Q6ZWP6
has only substance units: false
is: SBO:0000252
constant: false
name: ACAD8
is encoded by: hsa:27034
boundary condition: true
initial concentration: NaN

metaR PAIL HStn
product: MODEL1310110007#
name: phosphatidylinositol nuclear transport (diffusion)
reactant: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110007#
is: SBO:0000185

metaM atp c
constant: false
boundary condition: false
is: CHEBI:30616
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
name: ATP(4-)
is: HMDB00538
is: C00002
is: SBO:0000247

metaM ile L e
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
boundary condition: false
is: CHEBI:17191
is: HMDB00172
has only substance units: false
is: SBO:0000247
type: Species
constant: false
name: L-isoleucine
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_d93da243_cfd9_4418_ae36_baf2697b0fbf
initial concentration: NaN
name: CHAT
boundary condition: true
constant: false
initial amount: NaN
is: Q6LEN6
is: SBO:0000252
type: Species
is encoded by: hsa:1103
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_e5876bb6_6a73_4173_b9bc_79e00fb0d46a
name: ATG9B
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: Q674R7
is encoded by: hsa:285973

http://identifiers.org/biomodels.db/MODEL1310110007#_70af4c1c_1700_4e52_b95b_67542867a312
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:2348
initial concentration: NaN
constant: false
is: SBO:0000252
name: FOLR1
type: Species

metaR r2376
product: MODEL1310110007#
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false

metaM m8masn r
is: C05876
notes: FORMULA: C70H117N2O55X CHARGE: 0
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species

metaM met L c
is: SBO:0000247
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: CHEBI:16643
is: HMDB00696
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
name: L-methionine
initial amount: NaN
has only substance units: false

metaR PRPPS
reactant: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.6.1
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110007#
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reversible: true
is: SBO:0000176
name: phosphoribosylpyrophosphate synthetase
is described by: ECO:0000000
fast: false

metaM cdp n
boundary condition: false
is: SBO:0000247
is: HMDB01546
name: CDP(3-)
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:58069
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
has only substance units: false
constant: false

metaM h2o l
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: water
is: CHEBI:15377
is: SBO:0000247
is: HMDB02111
type: Species
constant: false

metaM akg e
is: SBO:0000247
constant: false
name: 2-oxoglutarate(2-)
boundary condition: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial amount: NaN
type: Species
is: HMDB00208
has only substance units: false
is: CHEBI:16810
initial concentration: 1.0

metaR HEX7
fast: false
reactant: MODEL1310110007#
name: hexokinase (D-fructose:ATP)
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
reversible: false
modifier: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.1.1
is version of: http://identifiers.org/ec-code/2.7.1.2
type: Reaction
product: MODEL1310110007#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110007#_5a719ec1_beb5_4e21_bcf8_8a908b8ba9ef
is encoded by: hsa:6389
initial amount: NaN
is: SBO:0000297
boundary condition: true
is encoded by: hsa:6392
type: Species
has part: P21912
is encoded by: hsa:6390
constant: false
has part: P31040
name: SDHA:SDHB:SDHC:SDHD
has part: Q99643
has part: O14521
is encoded by: hsa:6391
has only substance units: false
initial concentration: NaN

metaR THMP
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD
product: MODEL1310110007#
name: thiamin phosphatase
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#

metaM strdnccoa c
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205473
name: stearidonyl coenzyme A
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB06519
is: C16163
type: Species
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
initial amount: NaN

metaM cytd e
initial amount: NaN
has only substance units: false
is: C00475
is: HMDB00089
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: CHEBI:17562
name: Cytidine
constant: false

metaR r1920
kinetic law: MODEL1310110007#
fast: false
type: Reaction
product: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110007#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110007#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110007#_4302f7b1_a0c1_4f82_ab2d_fdf4b4bcc799
is: Q06203
is encoded by: hsa:5471
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
name: PPAT

http://identifiers.org/biomodels.db/MODEL1310110007#_e7f79296_800d_40de_9b2c_dc450ee590cb
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:279
initial amount: NaN
name: AMY2A
boundary condition: true
has only substance units: false
type: Species
is: P04746

metaM hx2coa m
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
initial concentration: 1.0
name: trans-Hex-2-enoyl-CoA
type: Species

metaR r1651
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110007#
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM fucgalgbside hs c
initial amount: NaN
type: Species
has only substance units: false
name: fucosyl galactosylgloboside
constant: false
is: CHEBI:18287
is: SBO:0000247
is: HMDB00174
notes: FORMULA: C56H99N2O31FULLRCO CHARGE: 0
boundary condition: false
initial concentration: 1.0

metaM sgalside hs l
is: HMDB00904
is: CHEBI:16349
boundary condition: false
has only substance units: false
name: sulfatide galactocerebroside
initial concentration: 1.0
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
constant: false
type: Species
initial amount: NaN
is: SBO:0000247

metaR FALDtly
kinetic law: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
name: formaldehyde transport via diffusion (lysosomall)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110007#

metaR r0385
fast: false
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
product: MODEL1310110007#
reversible: false
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_602ba4e0_dadd_451b_b2e2_4b4cdde45e5b
boundary condition: true
name: NT5M
has only substance units: false
is: SBO:0000252
is: Q9NPB1
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:56953
constant: false

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaR ALASm
is version of: http://identifiers.org/ec-code/2.3.1.29
product: MODEL1310110007#
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.3.1.37
modifier: MODEL1310110007#
fast: false
is: SBO:0000176
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
name: 5-aminolevulinate synthase
type: Reaction
reversible: false

metaM h2o n
name: water
boundary condition: false
type: Species
is: CHEBI:15377
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR PETOHMm hs
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.1.17
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
name: phosphatidylethanolamine N-methyltransferase
fast: false
product: MODEL1310110007#
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000176
reactant: MODEL1310110007#
is described by: ECO:0000254
reversible: false

metaR r0549
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
is version of: http://identifiers.org/ec-code/6.1.1.17
product: MODEL1310110007#
modifier: MODEL1310110007#
reversible: true
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.6.5.3
is version of: http://identifiers.org/ec-code/1.6.99.3
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_42a78f94_892f_4aae_bb7d_6453fb454ba0
is: SBO:0000252
is: P00338
name: LDHA
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:3939
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_16e6eabe_82f1_499e_9fd2_2feea7f8cc52
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is: Q6YFQ2
has only substance units: false
is encoded by: hsa:125965
name: COX6B2
constant: false
is: SBO:0000252

metaM HC00361 c
initial amount: NaN
boundary condition: false
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
initial concentration: 1.0
name: sedoheptulose 1,7-bisphosphate(4-)
type: Species
has only substance units: false
is: CHEBI:58335
is: SBO:0000247
constant: false

metaM hco3 e
has only substance units: false
initial concentration: 1.0
is: CHEBI:17544
name: Bicarbonate
is: C00288
is: SBO:0000247
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00595
constant: false

metaM dgchol x
is: HMDB00637
is: CHEBI:36252
initial concentration: 1.0
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
has only substance units: false
name: glycochenodeoxycholate
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
constant: false

metaM formcoa x
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57376
initial amount: NaN
type: Species
name: formyl-CoA(4-)
initial concentration: 1.0
is: HMDB03419

metaM urea c
is: CHEBI:16199
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
has only substance units: false
name: Urea
boundary condition: false
constant: false
is: C00086
is: SBO:0000247
type: Species
is: HMDB00294
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_d3bbba00_cd69_477b_9b43_10f8867d39f3
is encoded by: hsa:3635
name: INPP5D
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is: Q92835
has only substance units: false

metaR r0384
fast: false
product: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
reactant: MODEL1310110007#
reversible: false
kinetic law: MODEL1310110007#

metaR S6TASE23ly
fast: false
is described by: ECO:0000000
modifier: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
type: Reaction

metaR S6TASE19ly
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110007#
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110007#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110007#
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_e1a5aac7_da4b_4c5f_8542_1043583f10d7
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
name: PYCR1
is: P32322
is encoded by: hsa:5831
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_4905efda_76b0_48a1_a166_d4bbe3be92c2
initial amount: NaN
is encoded by: hsa:191
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: B3KUN3
constant: false
is: SBO:0000252
name: AHCY

metaM bhb m
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:10983
initial amount: NaN
name: (R)-3-hydroxybutyrate
is: HMDB00011
boundary condition: false
constant: false

metaM oretn n
initial concentration: 1.0
name: 4-oxo-retinoic acid
notes: FORMULA: C20H27O3 CHARGE: -1 INCHI: InChI=1/C20H26O3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21)11-12-20(17,4)5/h6-10,13H,11-12H2,1-5H3,(H,22,23)/p-1
is: CHEBI:58190
is: HMDB00224
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaR MI34PP
fast: false
notes: GENE_ASSOCIATION: (3631.2) or (3631.1) or (8821.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:7608176,PMID:9295334 NOTES:NCD
name: inositol-3,4-bisphosphate 4-phosphatase
product: MODEL1310110007#
is: SBO:0000176
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.3.66
reversible: false
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#

metaM pail345p hs c
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
boundary condition: false
is: CHEBI:57836
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaM ksii core4 deg2 l
constant: false
is: CHEBI:12936
type: Species
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
name: keratan sulfate II (core 4-linked), degradation product 2
is: HMDB00143
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaM cdp c
is: HMDB01546
initial concentration: 1.0
constant: false
is: CHEBI:58069
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
is: C00112

metaR DMHPTCRNt
reactant: MODEL1310110007#
product: MODEL1310110007#
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES:dmhptcoa is 'special' because its biochemical fat isn't known NJ
is: SBO:0000185
name: 2,6 dimethylheptanoyl crn transport

http://identifiers.org/biomodels.db/MODEL1310110007#_66bb6ab5_0e0e_41c2_aa7e_03c0e17614c3
name: IDH2
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3418
type: Species
is: P48735
is: SBO:0000252

metaM odecoa c
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:3793
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial amount: NaN
is: HMDB01322
boundary condition: false
constant: false
name: Octadecenoyl-CoA (n-C18:1CoA)

metaM h2o m
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
name: H2O
is: C00001
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB02111
initial amount: NaN
boundary condition: false
is: CHEBI:15377

http://identifiers.org/biomodels.db/MODEL1310110007#_0e9729fe_a57a_4b0b_957f_e5e39bb2b5f9
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaR CHLPCTD
is version of: http://identifiers.org/ec-code/2.7.7.15
type: Reaction
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (5130.1) or (9468.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.15 Confidence Level: 4 AUTHORS: NOTES:NCD
is described by: ECO:0000269
reversible: false
name: choline phosphate cytididyltransferase
product: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
is: SBO:0000176

metaR RE1525M
name: RE1525
is: SBO:0000176
modifier: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
type: Reaction
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110007#

metaR r1602
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110007#
product: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110007#

metaR RADH2
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
fast: false
reactant: MODEL1310110007#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
name: retinal dehydrogenase (NADPH)

metaR GALASE17ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
fast: false
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110007#
name: beta-galactosidase, lysosomal
product: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
is described by: ECO:0000000
reversible: false

metaR CREATt4 2 r
kinetic law: MODEL1310110007#
name: Creatine transport (sodium symport) (2:1)
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
reactant: MODEL1310110007#
modifier: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000269

metaR r1576
is: SBO:0000185
reactant: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110007#
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_e9ae8659_2694_4aa6_b3e1_2b7e7421e68d
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:J03866
initial concentration: NaN
initial amount: NaN
name: _J03866_1_m

metaM dmhptcoa m
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
name: 2,6 dimethylheptanoyl-CoA
constant: false
is: HMDB06258
notes: FORMULA: C30H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C30H52N7O17P3S/c1-17(2)7-6-8-18(3)29(42)58-12-11-32-20(38)9-10-33-27(41)24(40)30(4,5)14-51-57(48,49)54-56(46,47)50-13-19-23(53-55(43,44)45)22(39)28(52-19)37-16-36-21-25(31)34-15-35-26(21)37/h15-19,22-24,28,39-40H,6-14H2,1-5H3,(H,32,38)(H,33,41)(H,46,47)(H,48,49)(H2,31,34,35)(H2,43,44,45)/p-4/t18-,19+,22-,23-,24?,28+/m0/s1
initial concentration: 1.0

metaM asp L e
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00191
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
has only substance units: false
is: SBO:0000247
name: L-aspartate(1-)
constant: false
initial concentration: 1.0
is: CHEBI:29991

metaM dtdp m
has only substance units: false
initial amount: NaN
name: dTDP
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
is: C00363
is: HMDB01274
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
boundary condition: false
is: CHEBI:58369

http://identifiers.org/biomodels.db/MODEL1310110007#_ae85fbc3_e947_43ae_8274_4530962c56e3
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:AL050025
is: SBO:0000252
name: _AL050025_1_c

metaR r0497
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
is version of: http://identifiers.org/ec-code/1.2.4.2
product: MODEL1310110007#
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
reactant: MODEL1310110007#

metaM 1p3h5c m
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: HMDB01369
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
constant: false
is: CHEBI:6151

http://identifiers.org/biomodels.db/MODEL1310110007#_c94fa640_8328_4dbf_90ee_06bef1abb428
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: PNPLA4
boundary condition: true
is encoded by: hsa:8228
constant: false
is: P41247
type: Species

metaR FAOXC102C81m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

metaM 6a2ohxnt x
initial amount: NaN
type: Species
name: 6-amino-2-oxohexanoic acid
is: HMDB12151
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:17534
has only substance units: false

metaM glac c
boundary condition: false
initial concentration: 1.0
is: HMDB06355
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
name: D-glucurono-6,3-lactone
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
is: CHEBI:18268

http://identifiers.org/biomodels.db/MODEL1310110007#_3d0a141d_55d6_4234_968f_0fd95be6be6b
is encoded by: hsa:771
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
is: O43570
boundary condition: true
name: CA12
initial concentration: NaN
type: Species

metaM 2mb2coa m
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
type: Species
has only substance units: false
constant: false
name: 2-methylcrotonoyl-CoA(4-)
is: HMDB02054
initial amount: NaN
is: SBO:0000247
is: CHEBI:57337
initial concentration: 1.0
boundary condition: false

metaR SMPD3g
is version of: http://identifiers.org/ec-code/3.1.4.12
product: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is described by: ECO:0000304
reactant: MODEL1310110007#
type: Reaction
modifier: MODEL1310110007#
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
reversible: false
fast: false
is: SBO:0000176

metaR r1575
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM hco3 c
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
is: C00288
is: HMDB00595
constant: false
name: Bicarbonate
initial amount: NaN
is: CHEBI:17544

metaM urea e
initial concentration: 1.0
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
name: Urea
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: C00086
is: HMDB00294
type: Species
initial amount: NaN
is: CHEBI:16199

metaM fum m
name: Fumarate
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00134
constant: false
is: CHEBI:29806
boundary condition: false
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
is: C00122
has only substance units: false

metaR r0119
product: MODEL1310110007#
type: Reaction
modifier: MODEL1310110007#
fast: false
reversible: false
is: SBO:0000176
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
is version of: http://identifiers.org/ec-code/5.1.3.14
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
reactant: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_6a995ea3_88a6_45ad_865e_87bf28124fc6
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: SGPL1
initial concentration: NaN
constant: false
is: O95470
is encoded by: hsa:8879

metaR UDPtl
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
product: MODEL1310110007#
is described by: ECO:0000000
name: udp intracellular transport
reactant: MODEL1310110007#
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110007#

metaM itacon m
constant: false
initial amount: NaN
is: HMDB02092
is: SBO:0000247
type: Species
initial concentration: 1.0
name: itaconate(2-)
boundary condition: false
has only substance units: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
is: CHEBI:17240

http://identifiers.org/biomodels.db/MODEL1310110007#_3b0ad9d1_08a8_40e9_b616_23e94068c19c
is encoded by: hsa:5305
type: Species
is: SBO:0000252
is: P48426
constant: false
name: PIP4K2A
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_447f9b39_ae7e_4336_a53c_01b5cb0c6423
boundary condition: true
is: SBO:0000252
name: PYCR1
has only substance units: false
initial concentration: NaN
is: A6NFM2
is encoded by: hsa:5831
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_143dade5_884e_4b5b_a103_cc77cea1188b
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: B4DGD7
name: IDS
constant: false
is: SBO:0000252
is encoded by: hsa:3423
has only substance units: false

metaR EX 3mlda LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-Methylimidazoleacetic acid exchange
type: Reaction

metaR UGLCNACtg
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
name: UDP-GlcNAc Golgi transport via CMP antiport
type: Reaction
reactant: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
fast: false
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_50233679_a9c0_459f_a37a_169eee3e85cc
is: O75747
constant: false
boundary condition: true
is encoded by: hsa:5288
name: PIK3C2G
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR 5HLTDL
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.1.1.28
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110007#
name: 5-Hydroxy-L-tryptophan decarboxy-lyase
reactant: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:1540578 NOTES:SAB
fast: false

metaR CITL
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
modifier: MODEL1310110007#
fast: false
reversible: false
product: MODEL1310110007#
name: Citrate lyase
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110007#_eb951ce2_be4e_4165_bc13_1844452ca797
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:4830
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: NME1

metaR r1574
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110007#
is: SBO:0000185
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_967d819a_58ff_4ad5_a124_734e2ddbc74e
is: SBO:0000252
has only substance units: false
name: ALG3
initial concentration: NaN
is encoded by: hsa:10195
initial amount: NaN
type: Species
constant: false
boundary condition: true

metaM Rtotal3coa c
name: R total 3 Coenzyme A
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:16189
is: HMDB01448
type: Species
has only substance units: false
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
is: SBO:0000247

metaM adrncoa c
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
name: adrenyl coenzyme A
is: C16170
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205480

metaR r1600
type: Reaction
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110007#

metaM asp L c
initial concentration: 1.0
constant: false
initial amount: NaN
name: L-aspartate(1-)
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
type: Species
has only substance units: false
is: HMDB00191
boundary condition: false
is: CHEBI:29991
is: SBO:0000247

metaR r1421
fast: false
type: Reaction
name: Free diffusion
kinetic law: MODEL1310110007#
is: SBO:0000185
reactant: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_bce8fc16_185c_4499_a890_acfdb851d121
is: Q15147
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5332
type: Species
name: PLCB4
boundary condition: true
constant: false

metaM arachd r
constant: false
is: HMDB01043
boundary condition: false
is: SBO:0000247
is: CHEBI:32395
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
name: arachidonate
type: Species
initial concentration: 1.0

metaM CE2433 m
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
boundary condition: false
is: CHEBI:57795
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
initial amount: NaN

metaM meoh l
name: methanol
initial amount: NaN
constant: false
is: HMDB01875
initial concentration: 1.0
is: CHEBI:17790
boundary condition: false
has only substance units: false
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_70e84daf_74d6_4983_aa5c_50ed4a7ca2f7
is encoded by: hsa:11001
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: O14975
type: Species
has only substance units: false
name: SLC27A2

metaM strdnccoa m
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB06519
is: C16163
is: http://identifiers.org/pubchem.compound/47205473
is: SBO:0000247
boundary condition: false
type: Species
name: stearidonyl coenzyme A
initial amount: NaN
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1

metaR DUTPDPn
is described by: ECO:0000269
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.6.1.23
type: Reaction
modifier: MODEL1310110007#
fast: false
name: dUTP diphosphatase, nuclear
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:

metaR DALAt2r
type: Reaction
reactant: MODEL1310110007#
reversible: true
fast: false
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000304
name: D-alanine transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
modifier: MODEL1310110007#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110007#_bd3b4b02_70f1_440e_9b85_c5696f38892b
type: Species
has only substance units: false
is encoded by: hsa:1962
has part: O15254
is encoded by: hsa:8310
has part: Q9NY65
is: SBO:0000297
constant: false
initial amount: NaN
name: EHHADH:ACAA1:HSD17B4:ACOX3
boundary condition: true
initial concentration: NaN

metaR r1605
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#

metaM 6pgl r
is: CHEBI:57955
type: Species
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
initial concentration: 1.0
is: HMDB01127
has only substance units: false
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false

metaR r1428
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
kinetic law: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#
reversible: true
name: Free diffusion
is described by: ECO:0000000
type: Reaction
fast: false

metaM ksi deg8 l
is: HMDB00143
is: CHEBI:12936
has only substance units: false
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
initial concentration: 1.0
constant: false
type: Species
name: keratan sulfate I, degradation product 8
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_61f51754_fab7_4166_9ef9_a44479e4075f
constant: false
is encoded by: hsa:57134
is: Q9NR34
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: MAN1C1
initial amount: NaN

metaR FATP9t
kinetic law: MODEL1310110007#
is described by: ECO:0000269
type: Reaction
reversible: true
is: SBO:0000185
fast: false
name: fatty acid electroneutral transport
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/6.2.1.7
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reactant: MODEL1310110007#

metaM nrpphrsf c
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB02062
is: http://identifiers.org/pubchem.compound/123747
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
name: Sulfate derivative of norepinephrine
constant: false
initial amount: NaN

metaR r1573
type: Reaction
kinetic law: MODEL1310110007#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r1649
kinetic law: MODEL1310110007#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110007#
is described by: ECO:0000000
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_bc6cb7e3_b31a_4934_93cf_619f6ef83c94
has only substance units: false
name: PIK3R1
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: E7EX19
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5295

metaM h2o r
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB02111
name: H2O
type: Species
constant: false
is: C00001
is: CHEBI:15377
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_9b786f5c_f5ed_4a16_8eef_3c9963df7440
type: Species
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
name: GCH1
initial amount: NaN
is: Q8IZH9
is encoded by: hsa:2643
initial concentration: NaN

metaM Ser Gly Ala X Gly l
is: HMDB02183
initial concentration: 1.0
is: CHEBI:36005
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
name: protein-linked serine residue (glycosaminoglycan attachment site)
boundary condition: false
notes: FORMULA: XH CHARGE: 0

metaR GLUPRT
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.14
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
type: Reaction
name: glutamine phosphoribosyldiphosphate amidotransferase
product: MODEL1310110007#
fast: false
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_8683ad23_560e_4cda_86a0_d6b904e8c017
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is: P36969
is encoded by: hsa:2879
name: GPX4
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_74f96509_5d74_430c_bf45_842315ec7ac1
is encoded by: hsa:9990
initial amount: NaN
is: Q9UHW9
boundary condition: true
type: Species
name: SLC12A6
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_ce572324_0e50_4d5a_851a_0de1c1c27d21
initial amount: NaN
is encoded by: hsa:7371
boundary condition: true
name: UCK2
is: SBO:0000252
initial concentration: NaN
is: Q9BZX2
type: Species
has only substance units: false
constant: false

metaR r1606
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110007#
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
is: SBO:0000185

metaR PHYTt
product: MODEL1310110007#
is: SBO:0000185
type: Reaction
name: fatty acid transport via diffusion
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is described by: ECO:0000000

metaR FUT11g
reversible: false
name: Galactoside 2-alpha-L-fucosyltransferase 1
is: SBO:0000176
fast: false
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110007#
is described by: ECO:0000269
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.4.1.69
kinetic law: MODEL1310110007#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_59107c26_274a_456b_86bd_2e91f0d0e47d
type: Species
is: SBO:0000252
has only substance units: false
is: Q02221
is encoded by: hsa:1339
name: COX6A2
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true

metaR NDPK9n
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
reactant: MODEL1310110007#
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
reversible: true
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000176
product: MODEL1310110007#

metaM dudp c
constant: false
is: C01346
name: dUDP
is: CHEBI:60471
boundary condition: false
initial amount: NaN
is: HMDB01000
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346

metaM thp2c c
has only substance units: false
is: HMDB12130
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
type: Species
constant: false
name: 1-piperideine-6-carboxylate
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16987
boundary condition: false
initial amount: NaN

metaR RDH1a
reversible: true
product: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000269
name: retinol dehydrogenase (all-trans,NADPH)
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
kinetic law: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.300
is version of: http://identifiers.org/ec-code/1.1.1.105
is: SBO:0000176
fast: false
reactant: MODEL1310110007#

metaM HC02204 c
initial amount: NaN
is: CHEBI:27624
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
type: Species
initial concentration: 1.0
constant: false
name: prostaglandin-b1
has only substance units: false

metaR DDPGAm
fast: false
product: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
reactant: MODEL1310110007#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_76f17192_f6af_433c_8eae_c4e908397458
is: Q59EH3
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true
is encoded by: hsa:52
name: ACP1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_e2a4e1e3_537c_44ff_b214_e6bdb901bbca
type: Species
constant: false
name: _AI601100_1_m
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI601100
boundary condition: true
initial amount: NaN

metaM dmnoncrn x
is: HMDB06202
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C18H37NO4 CHARGE: 0
type: Species
name: 4,8-dimethylnonanoyl carnitine

metaR r1647
product: MODEL1310110007#
is described by: ECO:0000000
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110007#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110007#
reversible: true
is: SBO:0000185

metaM ksi deg39 l
is: HMDB00143
type: Species
name: keratan sulfate I, degradation product 39
boundary condition: false
is: CHEBI:12936
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C48H81N3O36 CHARGE: 0

metaM uacgam g
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
has only substance units: false
is: HMDB00290
is: CHEBI:57705
is: SBO:0000247
constant: false
boundary condition: false

metaR FATP1t
type: Reaction
reactant: MODEL1310110007#
modifier: MODEL1310110007#
reversible: true
is described by: ECO:0000269
name: fatty acid electroneutral transport
is: SBO:0000185
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
fast: false
kinetic law: MODEL1310110007#

metaR DOLPGT1 Ler
is version of: http://identifiers.org/ec-code/2.4.1.267
type: Reaction
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
is described by: ECO:0000000
reactant: MODEL1310110007#
fast: false
product: MODEL1310110007#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#

metaM gly x
name: glycine
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB00123
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: CHEBI:15428
boundary condition: false
initial amount: NaN
has only substance units: false

metaM hs deg24 l
has only substance units: false
initial concentration: 1.0
name: GlcNAc-GlcA-(Gal)2-Xyl
type: Species
constant: false
boundary condition: false
is: CHEBI:16126
initial amount: NaN
notes: FORMULA: C31H50NO26 CHARGE: -1
is: SBO:0000247

metaR r1603
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaM akg m
name: 2-Oxoglutarate
is: CHEBI:16810
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00208
has only substance units: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial concentration: 1.0
boundary condition: false
is: C00026

http://identifiers.org/biomodels.db/MODEL1310110007#_e2e9c194_405a_4996_a8da_baff5988225e
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: SDHC
is: Q99643
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:6391
constant: false

metaR PSt3
name: phosphatidylserine transport
fast: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
reversible: true
is: SBO:0000185
product: MODEL1310110007#
is described by: ECO:0000269
reactant: MODEL1310110007#
type: Reaction

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaM fuc L l
has only substance units: false
type: Species
initial concentration: 1.0
name: L-fucose
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
constant: false
initial amount: NaN
is: HMDB00174
boundary condition: false
is: SBO:0000247
is: CHEBI:18287

metaR NDPK1n
reversible: true
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
fast: false
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110007#
modifier: MODEL1310110007#
type: Reaction

metaR IDOAASE3ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.76
kinetic law: MODEL1310110007#
name: alpha-L-iduronidase, lysosomal
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110007#
modifier: MODEL1310110007#
product: MODEL1310110007#

metaR r0196
type: Reaction
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
fast: false
is: SBO:0000176
reactant: MODEL1310110007#
product: MODEL1310110007#
reversible: true
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110007#_4ef365b8_1f7e_4b4d_960d_c801f5d846f7
constant: false
is: Q9Y672
is encoded by: hsa:29929
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
name: ALG6

metaR RE1898C
name: RE1898
is described by: ECO:0000000
kinetic law: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
fast: false
reversible: true
reactant: MODEL1310110007#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:

metaR r1571
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110007#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#

metaM nrpphrsf e
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/123747
has only substance units: false
is: HMDB02062
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
name: Sulfate derivative of norepinephrine

metaR PItx
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
is: SBO:0000185
product: MODEL1310110007#
reversible: true
name: Phosphate transporter, peroxisome
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110007#

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaR r1648
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110007#
is described by: ECO:0000000
modifier: MODEL1310110007#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110007#

metaM dolp L c
type: Species
is: CHEBI:57683
has only substance units: false
name: dolichyl phosphate(2-)
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
boundary condition: false

metaR LEUTA
reversible: true
type: Reaction
kinetic law: MODEL1310110007#
product: MODEL1310110007#
name: leucine transaminase
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
modifier: MODEL1310110007#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42

metaR r0494
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
reversible: true
reactant: MODEL1310110007#

metaR NOt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
fast: false
reversible: true
product: MODEL1310110007#
name: NO transport (diffusion)
kinetic law: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110007#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_464c519d_644c_4631_a340_dd0986b2c050
is encoded by: hsa:AI620219
type: Species
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
name: _AI620219_1_e
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_357919c7_bb4e_4f79_8395_4a44a737469f
type: Species
is encoded by: hsa:5831
name: PYCR1
is: A6NFM2
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false

metaM tchola x
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: taurocholate
initial amount: NaN
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
is: HMDB00036
is: CHEBI:36257
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_4d37264d_69bd_455e_804f_34809bac50eb
is: P21953
initial amount: NaN
name: BCKDHB
type: Species
constant: false
is encoded by: hsa:594
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_9e6c7d4d_fbef_49a0_a539_00e475374651
initial concentration: NaN
name: AOC2
constant: false
is: SBO:0000252
is encoded by: hsa:314
type: Species
initial amount: NaN
boundary condition: true
is: O75106
has only substance units: false

metaR r1604
is: SBO:0000185
fast: false
kinetic law: MODEL1310110007#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110007#

metaR NDPK1m
kinetic law: MODEL1310110007#
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is described by: ECO:0000254
is: SBO:0000176
reversible: true
fast: false
modifier: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
product: MODEL1310110007#

metaR CDS
notes: GENE_ASSOCIATION: (1040.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:ER membrane - but on cytosolic surface NJ
is described by: ECO:0000000
reversible: false
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.7.41
type: Reaction
fast: false
kinetic law: MODEL1310110007#
name: phosphatidate cytidylyltransferase
is: SBO:0000176
reactant: MODEL1310110007#
modifier: MODEL1310110007#

metaR GALASE16ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
name: beta-galactosidase, lysosomal
modifier: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110007#
reversible: false
fast: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4

metaM ksi deg31 l
name: keratan sulfate I, degradation product 31
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00812
is: CHEBI:16953
initial concentration: 1.0
constant: false
notes: FORMULA: C90H148N6O72S2 CHARGE: -2

metaR r1570
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110007#
product: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110007#_745ea358_1ec6_40cf_9d69_fd5c2880f03b
is encoded by: hsa:1807
is: Q14117
initial concentration: NaN
type: Species
name: DPYS
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false

metaM cdp e
type: Species
initial amount: NaN
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
name: CDP(3-)
is: HMDB01546
is: CHEBI:58069

metaR GRTTx
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.5.1.1
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
is: SBO:0000176
product: MODEL1310110007#
is described by: ECO:0000134
fast: false
type: Reaction
name: geranyltranstransferase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110007#_b6e385e1_f708_428e_8f6d_5be1f2639065
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:22934
boundary condition: true
is: SBO:0000252
name: RPIA
type: Species
constant: false
is: P49247

metaM glyb c
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00043
constant: false
initial amount: NaN
name: glycine betaine
initial concentration: 1.0
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: CHEBI:17750

http://identifiers.org/biomodels.db/MODEL1310110007#_ec56af91_29e1_4238_bfa5_40a7b43725ab
is: Q92911
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:6528
name: SLC5A5
type: Species
is: SBO:0000252

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaR OROTGLUt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
fast: false
reactant: MODEL1310110007#
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110007#
product: MODEL1310110007#
name: OROTGLUt
is: SBO:0000185

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaR HIBDm
kinetic law: MODEL1310110007#
fast: false
modifier: MODEL1310110007#
reactant: MODEL1310110007#
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.31
is: SBO:0000176
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
type: Reaction

metaM dtdp c
boundary condition: false
is: C00363
is: CHEBI:58369
type: Species
initial concentration: 1.0
name: dTDP
initial amount: NaN
constant: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274
is: SBO:0000247
has only substance units: false

metaM 3m4hpga c
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
is: http://identifiers.org/pubchem.compound/7909
type: Species
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB04061
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: C05583

http://identifiers.org/biomodels.db/MODEL1310110007#_75e32d9c_daa6_485b_82e7_352d40fecbbf
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: _AI348006_1_c
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:AI348006
type: Species

metaR r0113
fast: false
type: Reaction
reactant: MODEL1310110007#
reversible: false
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 0 AUTHORS: PMID:10431835,PMID:15748884,PMID:3740419,PMID:4337336,PMID:5063602,PMID:5417402,PMID:9305887,PMID:9305888 NOTES:
name: UDP-N-acetyl-D-glucosamine 2-epimerase Aminosugars metabolism EC:5.1.3.14
is: SBO:0000176
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/6.2.1.1
is described by: ECO:0000000
kinetic law: MODEL1310110007#
product: MODEL1310110007#

metaR INSTt4 2
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110007#
name: inositol transport via sodium symport
is described by: ECO:0000006
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD

metaR r1609
reversible: true
reactant: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110007#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_984a39db_3b70_4324_b61a_9d34b9c59261
boundary condition: true
is encoded by: hsa:8875
constant: false
has only substance units: false
type: Species
is encoded by: hsa:8876
is encoded by: hsa:55350
initial amount: NaN
has part: A8K7W0
has part: O95497
initial concentration: NaN
name: VNN3:VNN2:VNN1
is: SBO:0000297

metaR EX andrstrn LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Androsterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_3dd87e72_69cb_4dab_a95c_a50f52b5f0d4
is: F8WAB8
is: SBO:0000252
is encoded by: hsa:115286
boundary condition: true
name: SLC25A26
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species

metaM dhdascb e
is: CHEBI:58070
is: HMDB01264
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
boundary condition: false
has only substance units: false
name: dehydroascorbide(1-)
initial amount: NaN

metaM pglyc hs c
has only substance units: false
boundary condition: false
is: HMDB02704
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:21338
notes: FORMULA: CHARGE: 0
name: pglyc_hs[c]

metaM HC02204 e
name: prostaglandin-b1
initial amount: NaN
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27624
constant: false
has only substance units: false
boundary condition: false

metaM m4masn g
notes: FORMULA: C46H77N2O35X CHARGE: 0
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
constant: false
initial amount: NaN
is: C05881
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species

metaM cl c
is: HMDB00492
type: Species
is: CHEBI:3966
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
is: C00115
name: Chloride
notes: FORMULA: Cl CHARGE: -1
boundary condition: false
initial amount: NaN

metaR DNDPt34m
is described by: ECO:0000269
name: dGDP transport via dTDP antiport
type: Reaction
fast: false
reactant: MODEL1310110007#
modifier: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#
reversible: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR ATPtm
is described by: ECO:0000269
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is: SBO:0000185
type: Reaction
name: ADP/ATP transporter, mitochondrial
fast: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
product: MODEL1310110007#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110007#_f8828165_e075_49ff_8011_95c5f468432a
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:6515
is: SBO:0000252
name: SLC2A3
initial concentration: NaN
is: P11169
boundary condition: true
has only substance units: false

metaR THYOXt2
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
fast: false
kinetic law: MODEL1310110007#
reversible: true
modifier: MODEL1310110007#
is described by: ECO:0000269
is: SBO:0000185
name: T4 transport via facilitated diffusion
type: Reaction
reactant: MODEL1310110007#
product: MODEL1310110007#

metaM 2ddecdicoa m
boundary condition: false
type: Species
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: C05279
name: 2,6-dodecadienoylcoa
is: SBO:0000247
initial amount: NaN
is: HMDB11123
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_8355f03d_7d10_426e_ac40_413b530ea23a
name: PYCRL
initial concentration: NaN
is encoded by: hsa:65263
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
has only substance units: false
is: Q53H96

metaR ACGAMPM
name: phosphoacetylglucosamine mutase
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
kinetic law: MODEL1310110007#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.4.2.3
fast: false
type: Reaction
product: MODEL1310110007#
reactant: MODEL1310110007#
reversible: true
is: SBO:0000176
modifier: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_f7ad4400_a34c_4d18_b01c_0e1526c8c7cb
type: Species
is encoded by: hsa:115
is: SBO:0000252
name: ADCY9
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is: O60503

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaM mi134p c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
constant: false
is: HMDB01143
is: CHEBI:58414

metaR r0870
kinetic law: MODEL1310110007#
fast: false
is version of: http://identifiers.org/ec-code/3.6.4.13
is version of: http://identifiers.org/ec-code/2.7.7.72
is described by: ECO:0000000
name: Facilitated diffusion
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.3.4
is: SBO:0000185
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.1
reactant: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
type: Reaction

metaR ACACT10m
is described by: ECO:0000134
name: acetyl-CoA C-acetyltransferase, mitochondrial
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: true
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
product: MODEL1310110007#
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110007#

metaM g2m8mpdol L r
type: Species
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
notes: FORMULA: C1900H3128N20O720P20 CHARGE: -20
has only substance units: false
is: C05870
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0

metaM 10fthf5glu e
name: 10-formyltetrahydrofolate-[Glu](5)
notes: FORMULA: C40H45N11O19 CHARGE: -6
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00972
is: CHEBI:57454

http://identifiers.org/biomodels.db/MODEL1310110007#_902f8836_e948_46ad_b5fc_788eecdf6fa2
initial amount: NaN
constant: false
boundary condition: true
is: B4DIA3
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:6535
name: SLC6A8

metaR S6TASE14ly
reactant: MODEL1310110007#
is: SBO:0000176
reversible: true
modifier: MODEL1310110007#
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110007#
fast: false
is described by: ECO:0000000

metaM Tn antigen l
constant: false
is: C04383
name: Tn antigen
type: Species
initial concentration: 1.0
notes: FORMULA: C8H14NO5X CHARGE: 0
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM succ c
type: Species
has only substance units: false
name: Succinate
is: CHEBI:30031
initial concentration: 1.0
is: C00042
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
initial amount: NaN
is: HMDB00254
constant: false
is: SBO:0000247
boundary condition: false

metaM 2maacoa m
initial concentration: 1.0
name: 2-methylacetoacetyl-CoA(4-)
type: Species
initial amount: NaN
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
is: HMDB01157
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:57335

metaM h2o x
is: HMDB02111
initial amount: NaN
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: C00001
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
is: SBO:0000247
name: H2O

http://identifiers.org/biomodels.db/MODEL1310110007#_2b365ee1_7cf7_47c4_8a7c_650256a34927
initial amount: NaN
has only substance units: false
name: PIK3R1
constant: false
is: SBO:0000252
is encoded by: hsa:5295
boundary condition: true
is: P27986
type: Species
initial concentration: NaN

metaM HC02214 e
name: prostaglandin-f1alpha
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
type: Species
is: CHEBI:28852
boundary condition: false

metaM dutp m
constant: false
initial amount: NaN
is: HMDB01191
is: CHEBI:17625
has only substance units: false
initial concentration: 1.0
type: Species
name: dUTP
boundary condition: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_842488ff_236e_4224_b7f7_f6fc2bbbf051
type: Species
is: SBO:0000252
name: _AA788780_1_c
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AA788780
boundary condition: true

metaR r1607
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110007#
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110007#

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaM dtdp e
is: SBO:0000247
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB01274
is: CHEBI:58369
type: Species
constant: false
initial concentration: 1.0

metaR BAMPPALDOX
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
modifier: MODEL1310110007#
is: SBO:0000176
product: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.36
is described by: ECO:0000212

metaM ksi deg38 l
has only substance units: false
notes: FORMULA: C54H91N3O41 CHARGE: 0
is: CHEBI:12936
type: Species
name: keratan sulfate I, degradation product 38
is: HMDB00143
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_4e0ec87e_cb51_416f_9081_0c933730e136
type: Species
is: SBO:0000252
is encoded by: hsa:2720
name: GLB1
boundary condition: true
has only substance units: false
initial amount: NaN
is: P16278
initial concentration: NaN
constant: false

metaR GGH 10FTHF5GLUe
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
fast: false
modifier: MODEL1310110007#
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reversible: false
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_58d1a463_9342_42fe_979a_e0788b4aa020
is: SBO:0000252
type: Species
constant: false
is: G3V5N0
name: FUT8
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2530
has only substance units: false
initial amount: NaN

metaM ctp e
initial concentration: 1.0
is: HMDB00082
has only substance units: false
is: SBO:0000247
name: CTP(4-)
type: Species
initial amount: NaN
is: CHEBI:37563
boundary condition: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_5eb03f42_c571_4e8b_b4af_4e90d31e04b9
name: NDUFA13
is: Q9P0J0
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:51079
initial concentration: NaN
type: Species

metaR r2437
product: MODEL1310110007#
type: Reaction
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
reactant: MODEL1310110007#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110007#

metaR r0193
is: SBO:0000176
kinetic law: MODEL1310110007#
fast: false
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
reversible: true
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
is described by: ECO:0000000
reactant: MODEL1310110007#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_2a98ba19_c829_4790_b70f_fe98d7f45469
is: Q92569
is encoded by: hsa:8503
has only substance units: false
name: PIK3R3
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaM atp x
initial concentration: 1.0
type: Species
name: ATP(4-)
initial amount: NaN
is: HMDB00538
boundary condition: false
is: CHEBI:57299
constant: false
is: SBO:0000247
is: C00002
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_a4ab5e75_70b0_420f_93a9_726a5ae9eed4
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:AA081045
initial concentration: NaN
name: _AA081045_1_e
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_6414944e_4bde_4881_886e_5aea52379062
constant: false
type: Species
initial amount: NaN
name: _NOS2A_1_c
is encoded by: hsa:NOS2A
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_a321af9a_ffa9_4047_83c6_f87722afd95f
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: _AI373818_1_m
constant: false
is encoded by: hsa:AI373818
type: Species

metaM HC02020 r
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
type: Species
name: Cholesterol-ester-palm
is: CHEBI:3663
notes: FORMULA: C43H76O2 CHARGE: 0 INCHI: InChI=1S/C43H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-23-41(44)45-36-28-30-42(5)35(32-36)24-25-37-39-27-26-38(34(4)22-20-21-33(2)3)43(39,6)31-29-40(37)42/h24,33-34,36-40H,7-23,25-32H2,1-6H3/t34-,36+,37+,38-,39+,40+,42+,43-/m1/s1
initial amount: NaN

metaR RE1573M
is described by: ECO:0000000
kinetic law: MODEL1310110007#
fast: false
is version of: http://identifiers.org/ec-code/5.3.3.8
is: SBO:0000176
modifier: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
reactant: MODEL1310110007#
reversible: true
name: RE1573
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

metaM dutp n
has only substance units: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
type: Species
is: CHEBI:17625
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
name: dUTP
is: HMDB01191
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_ee9ee43f_b587_4511_90f1_dd296afd7f22
constant: false
has only substance units: false
is: SBO:0000252
name: CA5B
type: Species
is: Q9Y2D0
boundary condition: true
is encoded by: hsa:11238
initial concentration: NaN
initial amount: NaN

metaR F1Atg
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110007#
name: F1alpha transport (from golgi to lysosome)

metaM CE5126 x
is: CHEBI:15748
name: (2R)-pristanoyl-CoA
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5126
type: Species
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00127
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_340ddb16_6a4d_4006_bf62_c7d9b06d3043
name: ECI1
is encoded by: hsa:1632
has only substance units: false
initial amount: NaN
constant: false
is: P42126
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR r1608
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110007#
fast: false
product: MODEL1310110007#

metaR FAOXC164C143m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_ec0886b6_5958_4389_ac9e_459058a2205f
initial amount: NaN
is encoded by: hsa:10965
initial concentration: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
name: ACOT2
is: P49753
is: SBO:0000252

metaR FAOXC123m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

metaM gly m
name: Glycine
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: HMDB00123
constant: false
is: SBO:0000247
is: C00037
is: CHEBI:15428
initial concentration: 1.0
boundary condition: false

metaM uacgam r
is: CHEBI:57705
type: Species
has only substance units: false
is: SBO:0000247
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
initial amount: NaN
constant: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
boundary condition: false
initial concentration: 1.0
is: HMDB00290

metaR H2Ot
kinetic law: MODEL1310110007#
product: MODEL1310110007#
modifier: MODEL1310110007#
name: H2O transport via diffusion
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:renamed from H20t5 to H2Ot NCD
reactant: MODEL1310110007#
type: Reaction
fast: false
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_376f9170_2a77_4566_a171_1c2681054831
boundary condition: true
is encoded by: hsa:4700
initial concentration: NaN
constant: false
type: Species
is: P56556
has only substance units: false
name: NDUFA6
is: SBO:0000252
initial amount: NaN

metaM HC02214 c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
has only substance units: false
name: prostaglandin-f1alpha
type: Species
is: CHEBI:28852
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_9fba646f_2d71_42ff_9abc_5fa60708a766
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
name: FH
is: P07954
is encoded by: hsa:2271
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR SARCStm
is: SBO:0000185
name: Sarcosine transport (mitochondrial)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000
product: MODEL1310110007#

metaR FAOXC102C101m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaM ha l
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
has only substance units: false
initial concentration: 1.0
name: hyaluronan
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:16336

metaR S6TASE10ly
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110007#
name: galactose-6-sulfate sulfatase, lysosomal
type: Reaction
fast: false
is: SBO:0000176

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_35c19c0d_8ace_4f88_a39e_1aa99a802d46
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
name: VNN3
type: Species
has only substance units: false
is encoded by: hsa:55350

metaM ctp c
name: CTP
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
type: Species
is: HMDB00082
has only substance units: false
constant: false
is: CHEBI:37563
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: C00063

metaM glac r
name: D-glucurono-6,3-lactone
type: Species
is: HMDB06355
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
is: SBO:0000247
is: CHEBI:18268
has only substance units: false
boundary condition: false
constant: false

metaR r0276
reversible: true
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
fast: false
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_e2092d91_de36_4fc1_95b5_7dc513dc6817
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3155
type: Species
name: HMGCL
initial amount: NaN
is: Q6IBC0
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_ab74b6fb_b47b_4daa_a70a_96dc7eac0d6d
is encoded by: hsa:196883
is: Q8NFM4
boundary condition: true
initial amount: NaN
name: ADCY4
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_e5a8ae30_7896_489c_8cfa_914b76abf040
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: P50747
name: HLCS
constant: false
is encoded by: hsa:3141
initial amount: NaN
type: Species

metaR GluForTx
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.5
reversible: false
reactant: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000269
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
is: SBO:0000176
type: Reaction
name: Glutamate formimidoyltransferase
kinetic law: MODEL1310110007#

metaM akg x
is: SBO:0000247
has only substance units: false
constant: false
name: 2-oxoglutarate(2-)
initial concentration: 1.0
is: CHEBI:16810
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00208
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026

http://identifiers.org/biomodels.db/MODEL1310110007#_0eac485b_00fd_4822_95f8_835063d7192f
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:BE966236
constant: false
name: _BE966236_1_c
initial concentration: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_a0ffffb2_b62a_4a04_b51e_e7a1e441490f
type: Species
is encoded by: hsa:6799
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P50226
is: SBO:0000252
has only substance units: false
name: SULT1A2

metaM 6pgc r
has only substance units: false
is: HMDB01316
is: SBO:0000247
is: CHEBI:58759
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: 6-phosphonatooxy-D-gluconate

metaM udpg c
initial concentration: 1.0
constant: false
has only substance units: false
name: UDPglucose
is: HMDB00286
boundary condition: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: SBO:0000247
is: CHEBI:58367
initial amount: NaN
is: C00029
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_aa987708_67c4_41cd_92eb_164279bef0cc
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P15121
is: SBO:0000252
name: AKR1B1
constant: false
type: Species
is encoded by: hsa:231

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaR UDPDOLPT L
fast: false
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
modifier: MODEL1310110007#
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.4.1.117
reactant: MODEL1310110007#
is described by: ECO:0000000

metaR AACOAT
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000269
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/6.2.1.16
name: Acetoacetyl-CoA:acetate CoA-transferase
reactant: MODEL1310110007#
fast: false
reversible: true

metaM mercplaccys c
is: HMDB06512
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
name: 3-mercaptolactate-cysteine disulfide
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_2254f47a_75e0_44b1_a25d_a319e092a561
boundary condition: true
has only substance units: false
constant: false
is: Q96QE2
type: Species
is encoded by: hsa:114134
is: SBO:0000252
initial concentration: NaN
name: SLC2A13
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_514da6a4_6778_4f9d_b7a2_a2f0fdb868ce
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9334
name: B4GALT5
is: O43286
initial amount: NaN
is: SBO:0000252
constant: false
type: Species

metaM meoh e
is: CHEBI:17790
is: HMDB01875
type: Species
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
has only substance units: false
initial concentration: 1.0
constant: false
name: methanol
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_8f04dc5f_82cc_4b32_9879_895e665059b0
is: Q5SYN6
constant: false
type: Species
name: SLC22A3
initial amount: NaN
is encoded by: hsa:6581
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR DCK2n
name: Deoxycytidine kinase, nuclear (UTP)
modifier: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
reactant: MODEL1310110007#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.74
fast: false
kinetic law: MODEL1310110007#

metaR LYStip
is: SBO:0000185
kinetic law: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
reversible: false
reactant: MODEL1310110007#
name: L-lysine transport, peroxisomal (irreversible)
is described by: ECO:0000000
product: MODEL1310110007#
fast: false

metaR CERT1gt
is: SBO:0000185
fast: false
reactant: MODEL1310110007#
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
reversible: true
product: MODEL1310110007#
name: ceramide transport protein
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
kinetic law: MODEL1310110007#
is described by: ECO:0000304

metaR LGNCt
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
fast: false

metaR NADPNe
is version of: http://identifiers.org/ec-code/3.2.2.5
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
fast: false
is described by: ECO:0000269
name: NADP nucleosidase,extracellular
product: MODEL1310110007#
reactant: MODEL1310110007#
reversible: false
notes: GENE_ASSOCIATION: (952.1) SUBSYSTEM: NAD metabolism EC Number: 3.2.2.6 Confidence Level: 4 AUTHORS: PMID:8394137 NOTES:See EC 3.2.2.5 for NAD nucleosidase
type: Reaction
is: SBO:0000176

metaR r1579
reactant: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_43156242_0995_40b4_9e8f_8069d862f7a1
type: Species
is encoded by: hsa:221
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P43353
name: ALDH3B1
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_7f0fe2a6_abf8_4097_aa9f_baa436b75e57
is: Q01968
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:4952
name: OCRL
is: SBO:0000252
initial concentration: NaN

metaR TDPm
reversible: false
reactant: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 2 AUTHORS: PMID:9755848 NOTES:_01-25-05 IT
name: thiamin pyrophosphatase, mitochondrial
fast: false

metaM atp r
is: C00002
has only substance units: false
constant: false
type: Species
boundary condition: false
is: CHEBI:57299
name: ATP(4-)
initial amount: NaN
is: SBO:0000247
is: HMDB00538
initial concentration: 1.0

metaR ADPT
reactant: MODEL1310110007#
fast: false
name: adenine phosphoribosyltransferase
type: Reaction
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.4.2.7
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (353.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.7 Confidence Level: 4 AUTHORS: PMID:14674717,PMID:15196008 NOTES:
reversible: false

metaR LPS3
is version of: http://identifiers.org/ec-code/3.1.1.23
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11343.1) or (11343.2) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.23 Confidence Level: 4 AUTHORS: PMID:9495531 NOTES:NJ
fast: false
product: MODEL1310110007#
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
name: lipase
modifier: MODEL1310110007#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110007#_feb0fc67_7cd6_4250_8c99_aa101915b021
name: MTMR3
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:8897

metaM CE2705 n
initial concentration: 1.0
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
boundary condition: false
is: CHEBI:15374
is: SBO:0000247
constant: false
type: Species
has only substance units: false
is: HMDB02281
name: quinonoid dihydrobiopterin
initial amount: NaN

metaM sphs1p r
boundary condition: false
type: Species
is: CHEBI:60119
is: SBO:0000247
is: HMDB00277
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
initial amount: NaN
name: sphingosine 1-phosphate(1-)
constant: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_1c32824f_2567_4053_92c5_fa0351d9dc7f
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6530
name: SLC6A2
constant: false
is: Q96KH8
initial amount: NaN

metaM fuc L c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
is: CHEBI:18287
initial amount: NaN
is: HMDB00174
has only substance units: false
name: L-fucose
type: Species
is: SBO:0000247
constant: false

metaR r1578
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110007#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#

metaM xoltriol c
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
initial amount: NaN
is: HMDB01457
initial concentration: 1.0
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
boundary condition: false
type: Species
is: CHEBI:16496
constant: false
has only substance units: false

metaR GALASE3ly
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
reactant: MODEL1310110007#
type: Reaction

metaM cl e
is: CHEBI:3966
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: Cl CHARGE: -1
is: C00115
initial concentration: 1.0
name: Chloride
initial amount: NaN
is: HMDB00492
type: Species

metaM Tn antigen g
initial amount: NaN
has only substance units: false
is: C04383
constant: false
notes: FORMULA: C8H14NO5X CHARGE: 0
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: Tn antigen

metaM thm c
notes: FORMULA: C12H17N4OS CHARGE: 1
initial concentration: 1.0
is: C00378
is: CHEBI:0
type: Species
is: HMDB00235
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
name: Thiamin

metaM cysam c
initial amount: NaN
name: cysteaminium
type: Species
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: HMDB02991
is: CHEBI:58029

metaR DM T antigen g
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

metaR PNTK
type: Reaction
name: pantothenate kinase
fast: false
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.33
product: MODEL1310110007#
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000176

metaR LPS2
is described by: ECO:0000000
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.1.34
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
reactant: MODEL1310110007#
type: Reaction
fast: false
is: SBO:0000176
name: lipase
modifier: MODEL1310110007#
reversible: false

metaM mercplaccys e
boundary condition: false
is: HMDB06512
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
initial amount: NaN
name: 3-mercaptolactate-cysteine disulfide

metaM CE4872 m
has only substance units: false
boundary condition: false
is: CHEBI:15748
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
is: SBO:0000247
initial concentration: 1.0
is: HMDB00127
initial amount: NaN
constant: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_cdf728a6_4ade_4215_b092_88e10c726392
is encoded by: hsa:60490
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: PPCDC
is: Q96CD2
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_684a6548_59e8_4d91_baed_ee91af5029ed
type: Species
is encoded by: hsa:1376
boundary condition: true
constant: false
is: P23786
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: CPT2
initial amount: NaN

metaM meoh c
is: SBO:0000247
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
has only substance units: false
type: Species
is: CHEBI:17790
is: HMDB01875
initial concentration: 1.0
name: methanol
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_7f58b961_2da8_4d55_9831_a9a74656879b
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q92781
name: RDH5
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5959
type: Species

metaM ptrc e
is: HMDB01414
is: CHEBI:326268
has only substance units: false
is: C00134
initial amount: NaN
name: Putrescine
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
type: Species
initial concentration: 1.0
constant: false

metaR EX CE5787 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-3 exchange
type: Reaction

metaR URATEt
is described by: ECO:0000000
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110007#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: urate export from cytosol
fast: false

metaR DINt
is: SBO:0000185
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
fast: false
reversible: true
name: deoxyinosine transport via diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110007#
product: MODEL1310110007#
type: Reaction

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_b109b658_75ac_4141_8fd0_252ad819c4d5
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:FLJ44968
constant: false
name: _FLJ44968_1_m
boundary condition: true

metaM pristcoa x
boundary condition: false
name: pristanoyl coa
is: CHEBI:51341
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false

metaR P4507A1r
is version of: http://identifiers.org/ec-code/1.14.13.17
is: SBO:0000176
name: cytochrome P450, family 7, subfamily A, polypeptide 1
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (1581.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.17 Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110007#
reversible: false
kinetic law: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_75bb6533_e800_473c_9c03_6fb8e0d4760c
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: _AI926493_1_m
has only substance units: false
is encoded by: hsa:AI926493
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_2844d269_13a3_46ac_b422_bbff509514f4
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:23428
name: SLC7A8:SLC3A2
initial concentration: NaN
has part: Q9UHI5
type: Species
is: SBO:0000297

metaR r2317
kinetic law: MODEL1310110007#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_d8147f41_03ee_4a5d_99e3_6bea988f72c8
boundary condition: true
type: Species
is: SBO:0000252
name: _NM_001929_1_c
has only substance units: false
initial amount: NaN
is encoded by: hsa:NM 001929
constant: false
initial concentration: NaN

metaR SPHS1Ptr
product: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
is: SBO:0000185
name: sphingosine-1-phosphate transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
type: Reaction
reversible: true
is described by: ECO:0000000

metaR CORE6GTg
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110007#
product: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
reversible: false
modifier: MODEL1310110007#
name: Core 6 beta-GlcNAc-transferase A, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.102
notes: GENE_ASSOCIATION: (2650.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110007#_d4ac8168_4aad_4e3a_8a94_95a122704838
constant: false
is: P49748
has only substance units: false
boundary condition: true
name: ACADVL
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:37
initial concentration: NaN
type: Species

metaR r2388
kinetic law: MODEL1310110007#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110007#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110007#
modifier: MODEL1310110007#

metaR DPMVDx
is: SBO:0000176
name: diphosphomevalonate decarboxylase
reversible: false
fast: false
modifier: MODEL1310110007#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.1.1.33
type: Reaction
reactant: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.1.33 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ

metaR r2088
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reversible: true
is: SBO:0000185
modifier: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110007#
product: MODEL1310110007#
fast: false

metaR NADtx
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
kinetic law: MODEL1310110007#
name: transport of NAD into peroxisome
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_00b9953f_e693_4756_a023_0a90f7698788
name: TXNRD1
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:7296
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_fec05ebe_ef3a_40d1_947c_86ee1c12a017
initial concentration: NaN
is: Q5JPA4
initial amount: NaN
name: SLCO1C1
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:53919
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_b651ef57_c1ac_4ce6_827d_230ccf537ba1
boundary condition: true
has only substance units: false
name: ETFB
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:2109
is: SBO:0000252
is: P38117

http://identifiers.org/biomodels.db/MODEL1310110007#_52aa7b35_5781_47fd_9544_3e5096d3b392
name: HEXB
initial amount: NaN
type: Species
is: P07686
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3074
constant: false
has only substance units: false
is: SBO:0000252

metaR FAOXC161802m
product: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
is described by: ECO:0000269
reversible: false
name: Beta oxidation fatty acid
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction

metaR EX 34hpp
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_11ba236b_6c66_4322_aa7c_c08666c33cc8
is: SBO:0000252
is: O95907
name: SLC16A8
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:23539
boundary condition: true
has only substance units: false

metaM methf m
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
name: (6R)-5,10-methenyltetrahydrofolate
is: SBO:0000247
is: CHEBI:57455
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
has only substance units: false
is: HMDB01354
boundary condition: false

metaR MI145PP
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.3.36
reactant: MODEL1310110007#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.56
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.86
modifier: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
name: inositol-1,4,5-trisphosphate 5-phosphatase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_afa27fa4_ee41_4248_9b3f_44bed3e6f779
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: SULT1A3
is: P50224
is encoded by: hsa:6818
boundary condition: true
initial concentration: NaN
type: Species

metaR r2316
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110007#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110007#
reversible: true
fast: false
product: MODEL1310110007#

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_0e627ef7_6ab8_412c_955a_9de03ff54209
boundary condition: true
name: PRDX2
constant: false
is: SBO:0000252
is encoded by: hsa:7001
has only substance units: false
is: P32119
initial amount: NaN
type: Species
initial concentration: NaN

metaR r2389
modifier: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
reversible: false
reactant: MODEL1310110007#

metaM leuktrA4 c
initial concentration: 1.0
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
has only substance units: false
constant: false
name: leukotriene A4(1-)
boundary condition: false
is: CHEBI:57463
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB01337

metaR RE1516M
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.3.99.13
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110007#
name: RE1516
reversible: true

metaR r2087
modifier: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110007#

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_668bcfdb_3b98_4c18_99df_5d87f8f48d2a
initial amount: NaN
is: Q14542
name: SLC29A2
initial concentration: NaN
is encoded by: hsa:3177
constant: false
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

metaM ak2lgchol hs c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
boundary condition: false
type: Species
is: C04317
is: http://identifiers.org/pubchem.compound/6975
has only substance units: false
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_521c4ab4_5773_4cb7_9661_c2c3df8e594c
is encoded by: hsa:8527
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: DGKD

http://identifiers.org/biomodels.db/MODEL1310110007#_5c52431f_792a_41a5_b188_1707ee9b0628
type: Species
constant: false
is: P06744
name: GPI
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:2821

http://identifiers.org/biomodels.db/MODEL1310110007#_65314340_f9a2_467d_9a3a_455e6f59d023
type: Species
name: SLC38A3
has only substance units: false
is encoded by: hsa:10991
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q99624

metaR TYRt
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
name: L-tyrosine transport
fast: false
modifier: MODEL1310110007#
is described by: ECO:0000269
reversible: true
product: MODEL1310110007#
type: Reaction

metaR PAIL45P HStn
reversible: true
product: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
fast: false
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
reactant: MODEL1310110007#
type: Reaction

metaR r2319
fast: false
is: SBO:0000185
kinetic law: MODEL1310110007#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110007#
reactant: MODEL1310110007#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110007#_58da0977_b732_4310_ad41_3dd5e303e6a4
initial concentration: NaN
boundary condition: true
has only substance units: false
name: FUT8
initial amount: NaN
is: A8K8P8
is: SBO:0000252
type: Species
is encoded by: hsa:2530
constant: false

metaM malcoa c
is: C00083
constant: false
is: SBO:0000247
name: Malonyl-CoA
initial concentration: 1.0
is: HMDB01175
boundary condition: false
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: CHEBI:57384
initial amount: NaN
type: Species
has only substance units: false

metaM glyald c
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: SBO:0000247
is: CHEBI:17378
boundary condition: false
is: HMDB01051
has only substance units: false
initial concentration: 1.0
type: Species
is: C00577
constant: false
name: D-Glyceraldehyde
initial amount: NaN

metaR LDH L
product: MODEL1310110007#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110007#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.27
name: L-lactate dehydrogenase
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D

metaR r2086
product: MODEL1310110007#
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110007#
reversible: true
reactant: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM gdpfuc c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
is: HMDB01095
type: Species
name: GDP-L-fucose(2-)
is: CHEBI:57984
constant: false
has only substance units: false
is: SBO:0000247

metaM 4hpro LT m
initial concentration: 1.0
type: Species
name: trans-4-hydroxy-L-proline
boundary condition: false
is: CHEBI:18095
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00725
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_08d43f58_b2d9_4f6c_90f1_250d116ead81
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
is: H7C5B8
is encoded by: hsa:4708
name: NDUFB2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_f3d7ce11_afc6_4e9d_a431_4984ef7f391f
has only substance units: false
initial concentration: NaN
type: Species
constant: false
boundary condition: true
name: PKM2
initial amount: NaN
is encoded by: hsa:5315
is: SBO:0000252

metaR LINKDEG1ly
name: degradation of proteoglycan linkage region, lysosomal
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
type: Reaction
is: SBO:0000176
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: false
product: MODEL1310110007#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_0c63154a_2ab0_44dc_9003_03b1ece35daf
type: Species
boundary condition: true
is: SBO:0000252
is: P43034
constant: false
has only substance units: false
name: PAFAH1B1
is encoded by: hsa:5048
initial amount: NaN
initial concentration: NaN

metaR GGH 6DHFl
type: Reaction
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
name: Gamma-glutamyl hydrolase (6DHF), lysosomal
fast: false
is: SBO:0000176
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110007#
is described by: ECO:0000000
reversible: false
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_0214fc3b_d721_495f_bf64_7464f565fec0
has only substance units: false
boundary condition: true
is: Q6P1M0
initial concentration: NaN
is encoded by: hsa:10999
constant: false
type: Species
initial amount: NaN
name: SLC27A4
is: SBO:0000252

metaM hexe3coa m
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
name: 3-hexenoylcoa
is: HMDB06522
boundary condition: false
constant: false

metaR UREAt5
reversible: true
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:NCD
modifier: MODEL1310110007#
name: urea, water cotransport
product: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#

metaR ADPRDP
name: ADPribose diphosphatase
type: Reaction
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.6.1.13
is described by: ECO:0000269
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (11164.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.13 Confidence Level: 4 AUTHORS: PMID:10567213,PMID:10722730,PMID:12717453 NOTES:
is: SBO:0000176
reactant: MODEL1310110007#
fast: false
reversible: false

metaR RE1523M
is: SBO:0000176
name: RE1523
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR RE1233C
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.6.1.64
name: RE1233
is: SBO:0000176
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
is described by: ECO:0000000
product: MODEL1310110007#
type: Reaction
fast: false

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

metaR RE1342C
fast: false
name: RE1342
reactant: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
kinetic law: MODEL1310110007#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110007#

metaM mmcoa S m
initial amount: NaN
is: CHEBI:57327
constant: false
is: SBO:0000247
is: HMDB02310
initial concentration: 1.0
boundary condition: false
name: (S)-methylmalonyl-CoA(5-)
has only substance units: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_0a545f9d_e9f5_475d_8155_81e2b27c2948
name: PFAS
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q6P4B4
is encoded by: hsa:5198

http://identifiers.org/biomodels.db/MODEL1310110007#_8ff2c9a8_96ae_4d79_9fb8_4e4ea528a6ff
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:549
is: Q13825
boundary condition: true
initial amount: NaN
name: AUH
has only substance units: false

metaR r2318
product: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110007#
reversible: true
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_66955ddd_5e4b_49ca_8613_e1b9e1f80950
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
name: EHHADH
is encoded by: hsa:1962
is: Q9NY65

metaM ksi deg3 l
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
name: keratan sulfate I, degradation product 3
is: HMDB01356
is: CHEBI:57312
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
constant: false

metaR r2085
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110007#
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110007#
fast: false
modifier: MODEL1310110007#

metaM m6masnB2 g
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C58H97N2O45X CHARGE: 0
is: HMDB01356
is: CHEBI:57312
boundary condition: false

metaM dcyt n
constant: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: 2'-deoxycytidine
type: Species
is: HMDB00014
is: CHEBI:15698

http://identifiers.org/biomodels.db/MODEL1310110007#_9c6f00e8_f6b8_47ff_a1ff_438229994f7b
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is: P16885
has only substance units: false
boundary condition: true
name: PLCG2
initial concentration: NaN
is encoded by: hsa:5336

http://identifiers.org/biomodels.db/MODEL1310110007#_00f8fefb_645e_4358_b9c1_9341ebf52a1c
initial amount: NaN
is encoded by: hsa:251
constant: false
initial concentration: NaN
is: P10696
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
name: ALPPL2

http://identifiers.org/biomodels.db/MODEL1310110007#_cf9da867_ab13_4c42_888f_5e14bec09cea
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:79087
is: Q9BV10
name: ALG12
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_7a416edc_3937_4533_a5b8_26abce156ae8
is encoded by: hsa:1892
boundary condition: true
is: P30084
name: ECHS1
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM mthgxl c
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
boundary condition: false
type: Species
is: HMDB01167
name: methylglyoxal
is: CHEBI:17158
has only substance units: false

metaR CSND
name: Cytosine deaminase
fast: false
type: Reaction
product: MODEL1310110007#
reversible: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
reactant: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110007#_8d82fffe_6023_4fb2_bed9_9fe0f025d649
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: SULT1A1
constant: false
initial concentration: NaN
has only substance units: false
is: P50225
is encoded by: hsa:6817

metaR EX chol LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Choline
type: Reaction

metaR ASPTAm
name: aspartate transaminase
kinetic law: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.6.1.1
reversible: true
product: MODEL1310110007#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110007#
modifier: MODEL1310110007#

metaM HC01405 m
boundary condition: false
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
name: (S)-Hydroxyoctanoyl-CoA
constant: false
type: Species
is: CHEBI:28632
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_2acba86e_6af7_461d_a9b0_3b1693948512
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: SLC25A2
type: Species
initial amount: NaN
is encoded by: hsa:83884
constant: false
has only substance units: false
is: Q9BXI2

metaM HC01118 r
type: Species
has only substance units: false
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57310
boundary condition: false
is: SBO:0000247
constant: false
name: presqualene diphosphate(3-)

http://identifiers.org/biomodels.db/MODEL1310110007#_fa9b78d4_d71d_44a9_8996_fbdf6df4ba5e
constant: false
has only substance units: false
is: P23919
name: DTYMK
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1841

metaR r2200
kinetic law: MODEL1310110007#
is: SBO:0000185
fast: false
product: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110007#

metaR r2384
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: false
product: MODEL1310110007#
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#

metaR LEUTAm
reactant: MODEL1310110007#
is: SBO:0000176
modifier: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000269
reversible: true
fast: false
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
name: leucine transaminase, mitochondrial
is version of: http://identifiers.org/ec-code/2.6.1.42

metaM 3hexdtricoa m
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: HMDB02288
constant: false
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
name: 3,7,10-hexadecatrienoylcoa

metaM gal1p c
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
is: HMDB00645
constant: false
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:58336

metaM HC01609 e
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:28766
constant: false
name: UroporphyrinogenI
is: SBO:0000247
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_11947461_d0ab_46ed_a534_c56781c91261
name: LDHA:LDHB
type: Species
has part: P00338
constant: false
is encoded by: hsa:3945
has only substance units: false
has part: P07195
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:3939

metaR DRPA
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
name: deoxyribose-phosphate aldolase
reversible: false
fast: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
product: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaM r5p r
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:18189
name: alpha-D-Ribose 5-phosphate
has only substance units: false
is: HMDB00618
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_fc12ee75_fbad_4b3a_9074_308cea1eae23
boundary condition: true
is encoded by: hsa:2584
constant: false
name: GALK1
is: P51570
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_d3772604_dec3_4fe7_9f6c_0898a323d085
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:1719
constant: false
name: DHFR
initial amount: NaN
initial concentration: NaN
is: P00374
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_64e007bc_8432_4fc7_9420_00e5668b4b49
type: Species
initial amount: NaN
has only substance units: false
name: _AI539321_1_c
is encoded by: hsa:AI539321
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false

metaM ribflv e
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: C00255
initial amount: NaN
is: HMDB00244
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: CHEBI:3554
type: Species
has only substance units: false
name: Riboflavin

http://identifiers.org/biomodels.db/MODEL1310110007#_93dc0323_e84a_4ce0_8643_452199faebfc
boundary condition: true
initial amount: NaN
name: GPX1
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2876
type: Species
has only substance units: false

metaR DCMPDA
product: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
is described by: ECO:0000254
reversible: true
is: SBO:0000176
name: dCMP deaminase
modifier: MODEL1310110007#
type: Reaction
fast: false
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.5.4.12

metaR ACNAMPH
fast: false
name: N-Acetylneuraminate 9-phosphate phosphohydrolase
is: SBO:0000176
product: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false
reactant: MODEL1310110007#

metaR r2385
reactant: MODEL1310110007#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
reversible: false
fast: false
kinetic law: MODEL1310110007#
type: Reaction
modifier: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR NACHEX10ly
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110007#

metaR F6Tg
is version of: http://identifiers.org/ec-code/2.4.1.68
reversible: false
reactant: MODEL1310110007#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
product: MODEL1310110007#
name: glycoprotein 6-alpha-L-fucosyltransferase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_c86f2901_4791_417d_a8a9_e42cc8e9e2e2
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:4645
boundary condition: true
is: Q9H6Y6
name: MYO5B

metaM dtmp m
is: SBO:0000247
type: Species
is: C00364
boundary condition: false
name: dTMP
is: HMDB01227
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
has only substance units: false
is: CHEBI:26999

metaR RE3421R
fast: false
kinetic law: MODEL1310110007#
product: MODEL1310110007#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
reactant: MODEL1310110007#
name: RE3421
is described by: ECO:0000000
reversible: true

metaR r0788
is: SBO:0000176
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110007#

metaR ARABR
name: arabinose reductase
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
type: Reaction
fast: false
reactant: MODEL1310110007#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.21
reversible: false
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.2

metaR r0860
is version of: http://identifiers.org/ec-code/4.1.2.27
fast: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110007#
product: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110007#
name: Utilized transport
is: SBO:0000185

metaM mthgxl e
has only substance units: false
is: HMDB01167
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
is: CHEBI:17158
is: SBO:0000247
name: methylglyoxal
constant: false
initial amount: NaN

metaR MI145PK
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000269
name: inositol-1,4,5-trisphosphate 3-kinase
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.127
type: Reaction
product: MODEL1310110007#

metaM hs deg15 l
has only substance units: false
is: CHEBI:16126
is: SBO:0000247
boundary condition: false
name: heparan sulfate, degradation product 15
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C49H71N2O57S5 CHARGE: -7

metaR TYRCBOX
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
is described by: ECO:0000134
modifier: MODEL1310110007#
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
name: L-Tyrosine carboxy-lyase
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.1.1.28
reversible: false
is: SBO:0000176

metaR 34HPPOR
is version of: http://identifiers.org/ec-code/1.13.11.27
is: SBO:0000176
reactant: MODEL1310110007#
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
is described by: ECO:0000269
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110007#
fast: false
type: Reaction
modifier: MODEL1310110007#
reversible: false

metaR NACASPtm
reactant: MODEL1310110007#
name: N-acetyl-L-aspartate transport (mitochondria to cytosol)
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11279290 NOTES:MM
type: Reaction
reversible: false
kinetic law: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaR DNDPt35m
product: MODEL1310110007#
modifier: MODEL1310110007#
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000269
name: dGDP transport via dADP antiport
reversible: false

metaM dd2coa m
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:57330
is: SBO:0000247
constant: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: HMDB03712
has only substance units: false
initial amount: NaN
name: trans-dodec-2-enoyl-CoA(4-)

metaR r2386
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110007#
type: Reaction
is: SBO:0000185
product: MODEL1310110007#
is described by: ECO:0000000
reversible: false
fast: false
reactant: MODEL1310110007#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

http://identifiers.org/biomodels.db/MODEL1310110007#_0523ddd9_a129_40e2_be2f_329fd3825017
type: Species
is: Q68CJ7
initial amount: NaN
constant: false
is: SBO:0000252
name: UROC1
boundary condition: true
initial concentration: NaN
is encoded by: hsa:131669
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_5346e0a1_c5ed_434c_9d9f_34dc8d3c6274
has only substance units: false
is encoded by: hsa:5298
initial amount: NaN
is: Q9UBF8
boundary condition: true
type: Species
name: PI4KB
constant: false
is: SBO:0000252
initial concentration: NaN

metaM prostgi2 r
has only substance units: false
is: CHEBI:57403
initial concentration: 1.0
name: prostaglandin I2(1-)
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: HMDB01335
is: SBO:0000247
type: Species

metaR r2202
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true
modifier: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
is: SBO:0000185
product: MODEL1310110007#

metaR r0122
kinetic law: MODEL1310110007#
name: GTP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
is: SBO:0000176
product: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110007#

metaM gdpfuc g
initial amount: NaN
is: HMDB01095
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
name: GDP-L-fucose(2-)
type: Species
is: CHEBI:57984

metaM 3ohdcoa m
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57349
is: SBO:0000247
name: 3-oxopalmitoyl-CoA(4-)
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
is: HMDB06402

metaM hmgcoa x
name: Hydroxymethylglutaryl-CoA
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
boundary condition: false
initial amount: NaN
is: HMDB01375
is: CHEBI:15467
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_391b6ab6_765d_407c_93de_e73bd137f525
is: SBO:0000252
has only substance units: false
name: FH
is encoded by: hsa:2271
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: P07954

metaR HSD17B4x
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
name: hydroxysteroid (17-beta) dehydrogenase 4
kinetic law: MODEL1310110007#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000269
reactant: MODEL1310110007#

metaM etfox m
is: CHEBI:57312
notes: FORMULA: R CHARGE: 0
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB01356
initial amount: NaN
name: Electron transfer flavoprotein oxidized
constant: false
has only substance units: false
boundary condition: false

metaR r0789
is: SBO:0000176
reactant: MODEL1310110007#
reversible: true
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
fast: false
kinetic law: MODEL1310110007#
is described by: ECO:0000000
modifier: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.14.13.15

metaM ksii core2 deg4 l
constant: false
is: HMDB00812
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 4
type: Species
initial amount: NaN
is: CHEBI:16953
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C58H95N5O43SX CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110007#_ecb40fc9_0d8f_498c_9b51_b04a2a4b08d2
is encoded by: hsa:4758
has part: Q99519
name: GALNS:GLB1:NEU1:CTSA
initial amount: NaN
is encoded by: hsa:2720
boundary condition: true
has only substance units: false
has part: P10619
is: SBO:0000297
is encoded by: hsa:2588
has part: P16278
has part: P34059
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:5476

metaM ribflv c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: C00255
constant: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
has only substance units: false
is: HMDB00244
initial amount: NaN
is: CHEBI:3554
type: Species
name: Riboflavin

http://identifiers.org/biomodels.db/MODEL1310110007#_0c1ed314_0747_4df2_af34_9a4ffba809a9
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:PRO1933
type: Species
name: _PRO1933_1_m
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false

metaM thcholstoic c
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB03873
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: CHEBI:18402

metaR r2201
product: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110007#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#

metaM ha pre1 e
has only substance units: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:16126
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
name: hyaluronan biosynthesis, precursor 1

metaR r2089
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110007#
is: SBO:0000185
reactant: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_6fe14937_ad17_4fa8_b9f5_80e791fb7088
has only substance units: false
name: NME1:NME2
is encoded by: hsa:4830
type: Species
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000297

metaM idour c
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:21338
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
name: L-iduronate
has only substance units: false
is: HMDB02704
initial concentration: 1.0

metaR r2387
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#
reactant: MODEL1310110007#
modifier: MODEL1310110007#

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR ST6GALNAC21
is version of: http://identifiers.org/ec-code/2.4.99.7
notes: GENE_ASSOCIATION: (10610.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.7 Confidence Level: 2 AUTHORS: NOTES:NJ
is: SBO:0000176
is described by: ECO:0000304
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reversible: false
type: Reaction
fast: false
name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
product: MODEL1310110007#
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_b34d9d78_b16f_43a0_95fe_71b625708b0f
name: _NM_013421_1_m
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:NM 013421
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM 3hpcoa m
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
is: HMDB06807
has only substance units: false
initial concentration: 1.0
is: CHEBI:58528
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 3-hydroxypropanoyl-CoA(4-)
constant: false

metaM leu L m
has only substance units: false
type: Species
is: CHEBI:15603
initial amount: NaN
is: HMDB00687
name: L-leucine
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
boundary condition: false
constant: false

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaR ALR3
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.21
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
product: MODEL1310110007#
modifier: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#
name: aldose reductase (acetol)
reactant: MODEL1310110007#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2

metaR r1584
reversible: true
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110007#
product: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110007#

metaR THBPT4ACAMDASE
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
kinetic law: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.96
product: MODEL1310110007#
reversible: false

metaR DITPtn
is: SBO:0000185
name: dITP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110007#
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110007#
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_0fce0422_a6f8_4d7e_8174_f62986198ac5
is encoded by: hsa:23428
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
name: SLC7A8:SLC3A2
type: Species
is: SBO:0000297
has only substance units: false
has part: Q86U05

metaM dolp L r
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial amount: NaN
name: dolichyl phosphate(2-)
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:57683

http://identifiers.org/biomodels.db/MODEL1310110007#_3fabceac_1e53_44c6_b753_203bd8dada73
is: Q9NY64
type: Species
name: SLC2A8
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:29988
has only substance units: false

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_8ae211e1_2bd5_470f_adf8_899f15de1e06
initial amount: NaN
boundary condition: true
name: SLC7A9
is: P82251
constant: false
initial concentration: NaN
is encoded by: hsa:11136
is: SBO:0000252
type: Species
has only substance units: false

metaR PAFt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110007#
product: MODEL1310110007#
name: 1-alkyl 2-acteylglycerol 3-phosphocholine transport
kinetic law: MODEL1310110007#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_d39630fc_15d1_450a_a458_935cd382ab61
is encoded by: hsa:79611
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: ACSS3
constant: false
is: Q9H6R3
type: Species

metaR PROSTGE2t2
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reversible: true
type: Reaction
fast: false
is described by: ECO:0000269
product: MODEL1310110007#
is: SBO:0000185
reactant: MODEL1310110007#
name: prostaglandin uniport

metaM leu L c
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: HMDB00687
name: L-leucine
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:15603
initial concentration: 1.0
constant: false

metaM dhap e
initial concentration: 1.0
boundary condition: false
name: glycerone phosphate(2-)
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
constant: false
is: CHEBI:57642
type: Species
is: HMDB01473

metaR r0437
modifier: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.2.13
reversible: true
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
reactant: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
fast: false

metaM eicostetcoa c
is: SBO:0000247
name: eicosatetranoyl coenzyme A
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
is: C16164
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_715a19d7_c93a_4a94_bc6e_e32cbf1969ae
type: Species
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:622
initial concentration: NaN
name: BDH1
is: SBO:0000252
initial amount: NaN

metaR r1585
type: Reaction
kinetic law: MODEL1310110007#
product: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110007#
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR DOLMANP Lter
product: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110007#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
fast: false
name: dolichol-phosphate mannose flippase (liver)
is: SBO:0000185
kinetic law: MODEL1310110007#

metaR ALR2
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
fast: false
reversible: false
is: SBO:0000176
name: aldose reductase (methylglyoxal)
modifier: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.21

http://identifiers.org/biomodels.db/MODEL1310110007#_1e735e91_986a_4207_833e_247a9f0c295d
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: ALOX5
is encoded by: hsa:240
boundary condition: true
has only substance units: false
constant: false
type: Species
is: P09917

metaM m4mpdol L c
initial amount: NaN
boundary condition: false
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
is: CHEBI:37633
type: Species
has only substance units: false
initial concentration: 1.0
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false
is: SBO:0000247

metaR r0129
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.1.40
reactant: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:

metaM acnam c
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: HMDB00230
name: N-acetylneuraminate
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:35418

http://identifiers.org/biomodels.db/MODEL1310110007#_b8509e39_9fc7_4d29_9226_dbff87f6bb0b
initial amount: NaN
is encoded by: hsa:51809
boundary condition: true
has only substance units: false
constant: false
name: GALNT7
is: Q86SF2
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_b6d9059b_9feb_4fd8_a4a5_234839f93d0b
is: SBO:0000252
name: PPAP2A
boundary condition: true
constant: false
is: G3XA95
initial amount: NaN
is encoded by: hsa:8611
has only substance units: false
initial concentration: NaN
type: Species

metaR r2380
reactant: MODEL1310110007#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
product: MODEL1310110007#

metaR GLUt7l
name: Glutamate transport, lysosomal
reversible: false
is: SBO:0000185
reactant: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
fast: false
product: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:IT

metaR ADPRIBt
name: ADPribose transport
is version of: http://identifiers.org/ec-code/3.2.2.5
notes: GENE_ASSOCIATION: (952.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8394137 NOTES:IT
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110007#
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110007#
modifier: MODEL1310110007#
product: MODEL1310110007#

metaR ASPTA
is version of: http://identifiers.org/ec-code/2.6.1.1
name: aspartate transaminase
is: SBO:0000176
product: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000269
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
reactant: MODEL1310110007#

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR r0224
fast: false
reversible: false
kinetic law: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000000
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
product: MODEL1310110007#
modifier: MODEL1310110007#

metaM pail hs c
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: CHEBI:57880
constant: false
has only substance units: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0

metaR r0377
type: Reaction
product: MODEL1310110007#
reversible: false
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_f9bebe96_14e0_4c54_baed_cf5079ef1b51
is: P27815
type: Species
name: PDE4A
has only substance units: false
initial amount: NaN
is encoded by: hsa:5141
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_780467a2_3928_44c1_a447_cf26f5d1ba21
constant: false
boundary condition: true
is: SBO:0000252
name: SLC24A1
initial amount: NaN
is: B4DUG1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:9187
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_153be048_378d_4574_8eb4_a4a7474d9434
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:126
has part: P00326
initial concentration: NaN
is: SBO:0000297
constant: false
has only substance units: false
name: ADH1B:ADH1C

metaM 4hpro LT e
boundary condition: false
initial amount: NaN
is: HMDB00725
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: trans-4-hydroxy-L-proline
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_6b1feafb_ed68_41b4_9296_8ddce13bdab2
constant: false
is: Q6NVC0
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:292
has only substance units: false
name: SLC25A5
is: SBO:0000252
initial amount: NaN

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaM 3hibutcoa m
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
is: HMDB01052
constant: false
type: Species
is: SBO:0000247
is: CHEBI:28259
name: (S)-3-Hydroxyisobutyryl-CoA
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_4562c758_5c61_4677_9b49_969c92074424
initial concentration: NaN
has only substance units: false
type: Species
name: PLCD3
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:113026
is: Q8N3E9

metaR ACNAM9PL
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110007#
is described by: ECO:0000269
type: Reaction
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD
fast: false
modifier: MODEL1310110007#
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.5.1.56

metaR r2382
kinetic law: MODEL1310110007#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110007#
modifier: MODEL1310110007#
reversible: false
product: MODEL1310110007#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_f777d241_d6bc_413a_9e2f_5eb8cf53cfb0
is encoded by: hsa:4507
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
is: Q13126
name: MTAP
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_4886a03c_fb4c_4de6_a072_1acd70c5d0cc
is encoded by: hsa:91703
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: Q96HD9
boundary condition: true
is: SBO:0000252
name: ACY3
type: Species

metaR DKMPPD
name: 2,3-diketo-5-methylthio-1-phosphopentane degradation reaction
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:JLR- based on B. subtilis and K. pneumoniae reactions (not sure about the h2o and h)
is: SBO:0000176
reactant: MODEL1310110007#
reversible: false

metaM acetone e
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:15347
constant: false
initial amount: NaN
is: HMDB01659
is: SBO:0000247
initial concentration: 1.0
name: acetone

metaR r2311
product: MODEL1310110007#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
is: SBO:0000185
reactant: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110007#

metaM dhap c
is: SBO:0000247
initial concentration: 1.0
name: Dihydroxyacetone phosphate
has only substance units: false
constant: false
boundary condition: false
is: HMDB01473
type: Species
is: http://identifiers.org/pubchem.compound/3411
initial amount: NaN
is: CHEBI:57642
is: C00111

metaM CE5120 m
has only substance units: false
is: SBO:0000247
name: trans-2-cis-8-tetradecadienoyl-CoA
type: Species
is: CHEBI:57923
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

metaR FAOXC101m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_86eb67cc_84d4_482d_a715_05d31f694e79
is: B3KQH0
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:55343
name: SLC35C1
constant: false
initial concentration: NaN

metaR FPGS4m
reactant: MODEL1310110007#
reversible: false
modifier: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110007#
name: folylpolyglutamate synthetase (DHF), mitochondrial
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/6.3.2.17
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT

metaR GGH 6DHFe
fast: false
modifier: MODEL1310110007#
name: Gamma-glutamyl hydrolase (6DHF), extracellular
type: Reaction
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110007#

metaR FAOXC184C164m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)m
type: Reaction

metaR 4MOPt2im
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110007#
reversible: false
fast: false
is: SBO:0000185
product: MODEL1310110007#
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport

metaR r1583
kinetic law: MODEL1310110007#
product: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110007#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110007#_ee0f0eab_9bdb_47f9_8f9a_40f80e89c972
type: Species
is: Q7Z364
name: PDE1B
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:5153

metaM udpglcur c
type: Species
is: CHEBI:58052
is: HMDB00935
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
boundary condition: false
is: C00167
name: UDP-D-glucuronate
has only substance units: false
constant: false

metaR r2310
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110007#

metaM dadp c
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: C00206
is: SBO:0000247
is: CHEBI:57667
name: dADP
is: HMDB01508
boundary condition: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206

metaR r0127
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.38 Confidence Level: 0 AUTHORS: PMID:4311065,PMID:4894450 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.16
product: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
is: SBO:0000176
name: L-Asparagine amidohydrolase Alanine and aspartate metabolism / Cyanoamino acid metabolism / Nitrogen metabolism EC:3.5.1.1 EC:3.5.1.38
reversible: false
kinetic law: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110007#

metaR UGALNACtg
type: Reaction
modifier: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
name: UDP-GalNAc Golgi transport via CMP antiport
reactant: MODEL1310110007#
fast: false
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_3b211021_dfd0_4abf_9897_40202e96001f
initial amount: NaN
name: GART
is: SBO:0000252
has only substance units: false
boundary condition: true
is: P22102
type: Species
is encoded by: hsa:2618
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_5fbd670c_5a1c_4190_b5e7_fb44f34ba6b2
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: _AA278423_1_m
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:AA278423
constant: false

metaM dopasf e
is: HMDB06275
name: dopamine 3-O-sulfate
initial amount: NaN
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
is: CHEBI:37946
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_6fa289b5_1a00_467c_aaef_56088f3e7404
is encoded by: hsa:5019
has only substance units: false
boundary condition: true
constant: false
is: P55809
type: Species
name: OXCT1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_9ebc3a16_3cca_4356_9f63_205db6132018
boundary condition: true
is encoded by: hsa:10873
is: SBO:0000252
is: Q6TCH8
type: Species
initial amount: NaN
constant: false
name: ME3
initial concentration: NaN
has only substance units: false

metaR PCHOLPm hs
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110007#
reversible: false
is: SBO:0000176
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
modifier: MODEL1310110007#
type: Reaction
name: choline phosphatase
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.4.4

metaM glyald m
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
name: D-glyceraldehyde
boundary condition: false
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB01051
is: CHEBI:17378
initial concentration: 1.0

metaM ha e
name: hyaluronan
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:16336
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518

metaR FUMSO4tm
reversible: true
is described by: ECO:0000269
fast: false
is: SBO:0000185
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
name: Fumarate:sulfate antiport, mitochondrial

metaR r0226
type: Reaction
reactant: MODEL1310110007#
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
kinetic law: MODEL1310110007#
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110007#
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
reversible: false

metaM dtmp c
is: CHEBI:26999
type: Species
is: HMDB01227
name: dTMP
has only substance units: false
boundary condition: false
is: SBO:0000247
is: C00364
constant: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial concentration: 1.0
initial amount: NaN

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_185102cf_2dca_40bb_a1f7_c57c0882ab0d
name: GGCT
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is: B8ZZR8
initial concentration: NaN
is encoded by: hsa:79017
initial amount: NaN
has only substance units: false

metaM acetone c
has only substance units: false
is: CHEBI:15347
type: Species
initial concentration: 1.0
constant: false
name: acetone
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01659

http://identifiers.org/biomodels.db/MODEL1310110007#_f643e263_9eb3_4695_ac24_f3ab5498fcc0
boundary condition: true
name: PPA2
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:27068
constant: false
initial concentration: NaN
is: SBO:0000252

metaR r1588
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#

metaM galgbside hs g
is: SBO:0000247
constant: false
type: Species
boundary condition: false
name: galactosylgloboside
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18259
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
has only substance units: false

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

metaM q10h2 m
is: http://identifiers.org/pubchem.compound/6504740
initial concentration: 1.0
name: Ubiquinol-10
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB13111
type: Species

metaR r2313
kinetic law: MODEL1310110007#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110007#
product: MODEL1310110007#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000

metaM paf hs e
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
type: Species
is: CHEBI:36707
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_0a6d808d_bca8_4666_b4cd_0ed49d38bf23
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is: O14521
name: SDHD
initial concentration: NaN
is encoded by: hsa:6392

http://identifiers.org/biomodels.db/MODEL1310110007#_7a7408a9_1fca_44a1_8ba9_04b7ab833754
constant: false
name: ENTPD6
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:955
is: O75354
boundary condition: true

metaM mhista c
type: Species
notes: FORMULA: C6H12N3 CHARGE: 1 INCHI: InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3/p+1 EHMN_ABBREVIATION: C05127
is: HMDB00898
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:58600
has only substance units: false
initial amount: NaN
name: N(tele)-methylhistaminium

metaR MEVK1x
type: Reaction
reactant: MODEL1310110007#
is described by: ECO:0000134
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.1.36
is: SBO:0000176
fast: false
kinetic law: MODEL1310110007#
reversible: false
product: MODEL1310110007#
name: mevalonate kinase (atp)
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.1.36 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version NJ

http://identifiers.org/biomodels.db/MODEL1310110007#_751a0a74_8725_4a86_b54f_156deadea0e1
type: Species
is encoded by: hsa:219
is: SBO:0000252
initial concentration: NaN
name: ALDH1B1
is: P30837
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false

metaR PROSTGD2t
name: prostaglandin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
reactant: MODEL1310110007#
type: Reaction
reversible: true
modifier: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
product: MODEL1310110007#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_fca7461e_8637_4060_8aa6_0a3f15e3ac52
type: Species
name: _AI440329_1_r
boundary condition: true
has only substance units: false
is encoded by: hsa:AI440329
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_4b068e75_3fc1_42dd_9357_85a677bf09dd
has only substance units: false
is: SBO:0000252
name: SLC4A5
is: Q9BY07
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:57835
type: Species
initial concentration: NaN

metaR ORNt3m
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reactant: MODEL1310110007#
name: ornithine mitochondrial transport via proton antiport
reversible: true
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110007#
is: SBO:0000185
modifier: MODEL1310110007#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_94842828_7a3a_40ba_abb5_76db8cf7fcea
is encoded by: hsa:221
type: Species
constant: false
is: P43353
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ALDH3B1

metaR FAOXC201C181x
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

metaM crn c
initial amount: NaN
constant: false
is: SBO:0000247
name: L-Carnitine
has only substance units: false
boundary condition: false
is: C00318
initial concentration: 1.0
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: HMDB00062
is: CHEBI:16347
type: Species

metaR SAMHISTA
name: S-Adenosyl-L-methionine:histamine N-tele-methyltransferase
is version of: http://identifiers.org/ec-code/2.1.1.8
product: MODEL1310110007#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (3176.1) SUBSYSTEM: Histidine metabolism EC Number: 2.1.1.8 Confidence Level: 4 AUTHORS: PMID:7943261 NOTES:SAB R02155
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
type: Reaction
reversible: false
reactant: MODEL1310110007#
fast: false

metaR SPHS1Pte
kinetic law: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
is described by: ECO:0000000
name: sphingosine-1-phosphate transport
product: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
fast: false
reversible: true

metaR r1589
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction

metaM lys L x
constant: false
is: HMDB00182
type: Species
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
boundary condition: false
name: L-lysinium(1+)
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:32551

http://identifiers.org/biomodels.db/MODEL1310110007#_2152d8e8_fe60_47a1_a15f_ad14c4a7325c
type: Species
constant: false
is encoded by: hsa:204
is: P54819
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: AK2
initial concentration: NaN

metaM 3ohdcoa x
is: SBO:0000247
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
is: HMDB06402
type: Species
has only substance units: false
is: CHEBI:57349
name: 3-oxopalmitoyl-CoA(4-)
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_45efb127_ba6d_4fde_adfb_474d51171b70
boundary condition: true
type: Species
constant: false
is encoded by: hsa:3992
is: SBO:0000252
initial amount: NaN
name: FADS1
initial concentration: NaN
is: O60427
has only substance units: false

metaM thcholstoic m
is: CHEBI:18402
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: HMDB03873
constant: false
has only substance units: false

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaR r2312
product: MODEL1310110007#
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185

metaR ACONTm
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
is: SBO:0000176
name: Aconitate hydratase
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.3
fast: false
kinetic law: MODEL1310110007#
is described by: ECO:0000134
product: MODEL1310110007#
reactant: MODEL1310110007#
modifier: MODEL1310110007#

metaR UAG4E
product: MODEL1310110007#
is: SBO:0000176
name: UDP-N-acetylglucosamine 4-epimerase
is described by: ECO:0000304
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/5.1.3.2
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
modifier: MODEL1310110007#
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false

metaR THYMDtm
fast: false
modifier: MODEL1310110007#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110007#
reversible: true
name: thymd transport
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:TDV
reactant: MODEL1310110007#

metaM CE2431 m
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57795
name: cis-deca-4-enoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110007#_1d763b66_a90b_4298_8d5f_3dc69015e528
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:AU149534
initial concentration: NaN
name: _AU149534_1_e

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaR EX CE5791 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 4-8 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_ecc75383_67c6_4312_8c39_15488b623fa5
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true
name: EHHADH
is: Q9NY65
initial amount: NaN
is encoded by: hsa:1962

metaR 5ADTSTSTERONEte
name: 5 alpha dihydrotesterone transport
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110007#
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR NDPK6n
type: Reaction
modifier: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
reversible: true
is described by: ECO:0000304
fast: false
reactant: MODEL1310110007#
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR EX hista LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Histamine exchange
type: Reaction

metaR GALASE18ly
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
modifier: MODEL1310110007#

metaR r1586
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
kinetic law: MODEL1310110007#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_b6c01107_b21a_4fee_9e40_ccd0697f4b0a
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
name: SULT1A1
has only substance units: false
is encoded by: hsa:6817

http://identifiers.org/biomodels.db/MODEL1310110007#_0f2cf443_b560_4a5e_b310_e04b34f3ec0e
boundary condition: true
has part: A7E2E0
has only substance units: false
is encoded by: hsa:8503
constant: false
name: PIK3CD:PIK3R3
has part: Q92569
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:5293
type: Species
initial amount: NaN

metaR ACGAMtly
type: Reaction
is: SBO:0000185
name: N-acetyl-glucosamine lysosomal efflux
product: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: false
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
is described by: ECO:0000000
fast: false

metaR r0408
product: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
is version of: http://identifiers.org/ec-code/1.4.3.5
fast: false
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
reactant: MODEL1310110007#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_049a7663_c7a8_492d_9645_44b6effee44c
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: B3GALNT1
type: Species
has only substance units: false
constant: false
is encoded by: hsa:8706
is: B3KTQ4
boundary condition: true

metaR MERCPLACCYSt
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000185
name: 3-mercaptolactate-cysteine disulfide transport, extracellular

metaR r2315
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110007#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110007#
reversible: true

metaM paf hs c
initial concentration: 1.0
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
is: CHEBI:36707
type: Species
boundary condition: false
has only substance units: false
constant: false

metaM dtmp e
constant: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
has only substance units: false
boundary condition: false
is: HMDB01227
type: Species
initial amount: NaN
is: CHEBI:26999
name: dTMP(2-)
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_623a8d4b_8a53_42f9_8a1e_cd9444468841
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:2645
has only substance units: false
type: Species
name: GCK
is: P35557
boundary condition: true

metaM gthox m
has only substance units: false
constant: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: HMDB03337
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58297
initial amount: NaN
boundary condition: false
type: Species

metaM 2mbcoa m
is: SBO:0000247
constant: false
is: CHEBI:57336
has only substance units: false
initial amount: NaN
name: 2-methylbutanoyl-CoA(4-)
initial concentration: 1.0
is: HMDB01041
type: Species
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
boundary condition: false

metaR r0630
modifier: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.1
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.3.2
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
reversible: true
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:

metaM leu L e
initial concentration: 1.0
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: HMDB00687
initial amount: NaN
is: CHEBI:15603
name: L-leucine
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_4f68c035_7ace_450d_864f_95868d1fbbc4
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
name: COX5A
boundary condition: true
initial amount: NaN
is: P20674
is encoded by: hsa:9377
has only substance units: false

metaR FAOXC103C102m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaR FE2t
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12440707 NOTES:
name: iron (II) transport
product: MODEL1310110007#
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#

metaM 2oxoadp m
name: 2-oxoadipate(2-)
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
boundary condition: false
initial concentration: 1.0
is: HMDB00225
is: SBO:0000247
initial amount: NaN
is: CHEBI:57499
constant: false
type: Species
has only substance units: false

metaM ha pre1 l
constant: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
initial concentration: 1.0
is: CHEBI:16126
boundary condition: false
is: SBO:0000247
name: hyaluronan biosynthesis, precursor 1
initial amount: NaN
has only substance units: false
type: Species

metaM crn e
has only substance units: false
is: CHEBI:16347
boundary condition: false
type: Species
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
constant: false
is: SBO:0000247
is: C00318
is: HMDB00062
initial concentration: 1.0
name: L-Carnitine
initial amount: NaN

metaR r1587
type: Reaction
kinetic law: MODEL1310110007#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110007#

metaR NDPK6m
kinetic law: MODEL1310110007#
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
fast: false
is described by: ECO:0000254
type: Reaction
product: MODEL1310110007#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reactant: MODEL1310110007#
modifier: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_d0efcc01_6650_425e_abc1_8d3c968dde86
is encoded by: hsa:50700
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: Q9NYR8
has only substance units: false
name: RDH8
initial concentration: NaN

metaM cbasp c
initial concentration: 1.0
is: C00438
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: HMDB00828
is: CHEBI:32814
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
type: Species
name: N-Carbamoyl-L-aspartate
is: SBO:0000247

metaR r2314
is described by: ECO:0000000
product: MODEL1310110007#
reversible: true
kinetic law: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction

metaR r0407
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
reversible: true
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000176
fast: false
product: MODEL1310110007#
type: Reaction
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.4.3.5

metaR RE0935E
reactant: MODEL1310110007#
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
reversible: true
product: MODEL1310110007#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.17
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
fast: false
name: RE0935

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_82d05077_89d1_4008_8d85_ff8799882297
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:80025
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: PANK2
has only substance units: false

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_46bccf02_ae93_4bf2_9acd_20638e05b8b1
is encoded by: hsa:1633
is: SBO:0000252
has only substance units: false
constant: false
is: P27707
name: DCK
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_2bcfc040_58ab_48c5_bb31_b4e70462e73b
has only substance units: false
is encoded by: hsa:1375
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q92523
type: Species
constant: false
initial concentration: NaN
name: CPT1B

http://identifiers.org/biomodels.db/MODEL1310110007#_61bbf183_6ead_4244_aaa1_827774e59987
is: SBO:0000252
is: Q92685
constant: false
has only substance units: false
is encoded by: hsa:10195
name: ALG3
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_df6dc454_c3ae_4da2_848e_71a571ad4175
initial amount: NaN
is: P22413
is: SBO:0000252
has only substance units: false
name: ENPP1
is encoded by: hsa:5167
type: Species
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_0d43ea72_bb64_4ef2_816b_c979c91898cb
name: ACHE
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is: P22303
initial amount: NaN
is encoded by: hsa:43
boundary condition: true

metaM mmcoa R m
is: HMDB01269
is: SBO:0000247
name: (R)-methylmalonyl-CoA(5-)
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
is: CHEBI:57326

metaR ALAR
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000212
name: alanine racemase
reactant: MODEL1310110007#
fast: false

metaM nh4 x
is: CHEBI:28938
type: Species
boundary condition: false
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
name: Ammonium
has only substance units: false
is: C01342
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_607532b3_d082_4ad1_a8dc_0207c02a93a4
boundary condition: true
constant: false
is: E9KL44
initial amount: NaN
is encoded by: hsa:3030
is: SBO:0000252
has only substance units: false
name: HADHA
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_dda9d01f_4d2d_490c_a7d7_1081f4cad5a3
boundary condition: true
is: O15254
type: Species
is encoded by: hsa:8310
has only substance units: false
name: ACOX3
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false

metaR 5MTHFt
is: SBO:0000185
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110007#
fast: false
type: Reaction
reactant: MODEL1310110007#
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
kinetic law: MODEL1310110007#

metaR GGT6
fast: false
reactant: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
product: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
reversible: true
name: Gamma-glutamyltransferase

metaR r0791
product: MODEL1310110007#
type: Reaction
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000000
modifier: MODEL1310110007#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true

metaR ADAe
is version of: http://identifiers.org/ec-code/3.5.4.4
type: Reaction
name: Adenosine deaminase, extracellular
is described by: ECO:0000269
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
product: MODEL1310110007#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110007#
fast: false
reactant: MODEL1310110007#

metaR AMANK
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/5.1.3.14
is version of: http://identifiers.org/ec-code/2.7.1.59
fast: false
is described by: ECO:0000269
reversible: false
name: N-acetyl-D-mannosamine kinase
notes: GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES:JLR - Kegg R02705
type: Reaction

metaM Sfglutth c
has only substance units: false
initial amount: NaN
name: S-formylglutathionate(1-)
constant: false
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
is: SBO:0000247
type: Species
is: CHEBI:57688
boundary condition: false
is: HMDB01550
initial concentration: 1.0

metaM ksi l
type: Species
is: C00445
initial amount: NaN
has only substance units: false
name: keratan sulfate I
boundary condition: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: HMDB01354
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:57455

metaR ECOAH12m
modifier: MODEL1310110007#
is described by: ECO:0000304
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM hs l
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
name: heparan sulfate, free chain
is: CHEBI:28815
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_1d0337d9_45a1_49c5_88a8_a796ce5fca71
initial amount: NaN
is: Q7LG56
initial concentration: NaN
is encoded by: hsa:50484
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
name: RRM2B
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_8fce39ed_c5b4_4303_94b2_2b4d48ee8797
constant: false
name: ALDH9A1
initial amount: NaN
type: Species
is: P49189
has only substance units: false
boundary condition: true
is encoded by: hsa:223
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_fae32e8e_d26c_4acc_8454_652974834874
has only substance units: false
is encoded by: hsa:2990
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: P08236
boundary condition: true
is: SBO:0000252
name: GUSB

http://identifiers.org/biomodels.db/MODEL1310110007#_e2816cb1_395f_4ede_9ec3_3475f8bf3bc9
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
name: NDUFA10
is: SBO:0000252
is encoded by: hsa:4705
has only substance units: false
is: O95299
constant: false

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaM cbasp e
is: HMDB00828
constant: false
is: C00438
initial concentration: 1.0
notes: FORMULA: C5H6N2O5 CHARGE: -2
initial amount: NaN
type: Species
is: CHEBI:32814
boundary condition: false
name: N-Carbamoyl-L-aspartate
is: SBO:0000247
has only substance units: false

metaR ACETONEt2
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
reactant: MODEL1310110007#
is described by: ECO:0000269
reversible: true
name: acetone transport via proton symport
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
product: MODEL1310110007#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110007#_1759ef77_2816_43a6_8207_0fd8bd439145
is: SBO:0000252
initial concentration: NaN
is: Q8WUM9
name: SLC20A1
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:6574

metaR r0594
fast: false
product: MODEL1310110007#
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
reversible: true
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110007#
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110007#_4c006e04_f5c6_46d9_a1ef_6b5c19adc7a3
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:5140
has only substance units: false
name: PDE3B
initial concentration: NaN
initial amount: NaN
is: A7E2E5

metaM h g
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:24636
boundary condition: false
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species
name: proton

metaM HC01415 m
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:27537
type: Species
initial amount: NaN
name: (2E)-Octenoyl-CoA
constant: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_7795cbac_09bb_4b82_9e60_d0b5b9f46e6e
constant: false
is: SBO:0000252
is encoded by: hsa:80724
boundary condition: true
initial concentration: NaN
is: G3XAJ0
initial amount: NaN
type: Species
has only substance units: false
name: ACAD10

http://identifiers.org/biomodels.db/MODEL1310110007#_12712cb2_732a_4bc1_8c2d_9b2062f97150
boundary condition: true
name: PRDX1
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5052
has only substance units: false
is: Q06830

metaR CITtbm
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
reversible: true
product: MODEL1310110007#
name: citrate transport, mitochondrial
is: SBO:0000185
reactant: MODEL1310110007#
type: Reaction
fast: false
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_dfd314d2_ae1f_4439_bc0f_cbbc3c305fe1
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: P05187
name: ALPP
is encoded by: hsa:250

metaM HC01602 c
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
is: C00234
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57454
type: Species
is: SBO:0000247
name: 10-Formyltetrahydrofolate
has only substance units: false

metaR PGI
reversible: true
product: MODEL1310110007#
name: glucose-6-phosphate isomerase
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
is: SBO:0000176
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/5.3.1.9
modifier: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#

metaM thyox L c
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: SBO:0000247
name: L-thyroxine
is: CHEBI:18332
initial concentration: 1.0
constant: false
is: HMDB00248

metaM HC00319 c
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
boundary condition: false
name: Malonate
has only substance units: false
initial concentration: 1.0
is: CHEBI:30794

metaM lys L m
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
is: HMDB00182
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:32551
is: SBO:0000247
name: L-lysinium(1+)
type: Species
has only substance units: false

metaR RE2814M
fast: false
name: RE2814
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000176
product: MODEL1310110007#

metaR GUAPRT
is: SBO:0000176
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
fast: false
name: guanine phosphoribosyltransferase
type: Reaction
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/2.4.2.8

http://identifiers.org/biomodels.db/MODEL1310110007#_eabc21c0_2481_492a_9fa3_b0be12ab425c
boundary condition: true
type: Species
is: SBO:0000252
name: TXNRD1
constant: false
initial amount: NaN
is encoded by: hsa:7296
initial concentration: NaN
has only substance units: false

metaM o2 r
constant: false
boundary condition: false
has only substance units: false
is: C00007
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
name: O2
type: Species
is: CHEBI:15379
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_89f7745a_fd62_4ba7_9317_f270f0beebc6
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: A8K3L7
initial concentration: NaN
is encoded by: hsa:10423
type: Species
constant: false
boundary condition: true
name: CDIPT

metaM idour l
initial concentration: 1.0
is: CHEBI:21338
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: HMDB02704
boundary condition: false
name: L-iduronate
is: SBO:0000247
type: Species

metaM hmgcoa c
is: CHEBI:15467
is: HMDB01375
initial concentration: 1.0
boundary condition: false
name: Hydroxymethylglutaryl-CoA
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_aa6a8fb6_7e06_47f1_9297_60786c9ab68e
has only substance units: false
initial concentration: NaN
is encoded by: hsa:257068
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
name: PLCXD2
type: Species
is: Q0VAA5

metaR NACHEX14ly
kinetic law: MODEL1310110007#
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110007#
is: SBO:0000176
reversible: false
modifier: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110007#_16197061_3d37_4b1b_810d_3a283d469e62
is: Q709F0
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:84129
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: ACAD11

http://identifiers.org/biomodels.db/MODEL1310110007#_0ddd9eb1_e9a3_48a6_9d81_cba211009c15
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2746
name: GLUD1
is: E9KL48
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_5f32b871_2485_46cc_8bce_acc57fba1ee9
initial amount: NaN
type: Species
initial concentration: NaN
is: B2RDU6
is: SBO:0000252
name: MVK
has only substance units: false
is encoded by: hsa:4598
constant: false
boundary condition: true

metaM HC02187 e
boundary condition: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
has only substance units: false
type: Species
name: reverse-triiodthyronine
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28774
initial amount: NaN

metaR H2O2tn
name: hydrogen peroxide nuclear transport
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
product: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction

metaM fald e
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
has only substance units: false
boundary condition: false
name: formaldehyde
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16842
constant: false
is: HMDB01426
is: SBO:0000247
type: Species

metaM hxan e
is: HMDB00157
boundary condition: false
is: CHEBI:17368
constant: false
is: SBO:0000247
name: hypoxanthine
initial amount: NaN
type: Species
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
initial concentration: 1.0
has only substance units: false

metaM ksii core2 deg5 l
has only substance units: false
is: HMDB00143
initial concentration: 1.0
is: CHEBI:12936
name: keratan sulfate II (core 2-linked), degradation product 5
notes: FORMULA: C50H82N4O38SX CHARGE: -1
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
boundary condition: false

metaR ARACHCRNt
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110007#
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110007#
reversible: false
product: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_3a975460_f612_4d8b_b21e_ab463b209972
has only substance units: false
is encoded by: hsa:4245
is: P26572
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
name: MGAT1
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_ae6e65d0_2b7b_40ac_b9a7_0984fc7b374a
constant: false
initial amount: NaN
is: O95497
type: Species
is: SBO:0000252
is encoded by: hsa:8876
has only substance units: false
name: VNN1
initial concentration: NaN
boundary condition: true

metaR NACHEX25ly
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110007#
is described by: ECO:0000000
modifier: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
reversible: false

metaR DGULND
kinetic law: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110007#
name: dehydro-L-gulonate decarboxylase
is: SBO:0000176
reversible: true

metaR r1365
fast: false
product: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110007#
reversible: false
name: Vesicular transport
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_05aa4bad_f34c_4107_991c_9ee506dccad8
name: _AD000092_1_c
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AD000092
constant: false
boundary condition: true
type: Species

metaR G16MT L
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000
name: Glycolipid 1,6-alpha-D-mannosyltransferase (liver)
type: Reaction
reversible: false
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110007#

metaM bildglcur c
boundary condition: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: CHEBI:58471
name: bis(beta-glucosyluronate)bilirubin
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB03325
initial concentration: 1.0

metaM hs deg25 l
boundary condition: false
has only substance units: false
notes: FORMULA: C23H37O21 CHARGE: -1
constant: false
initial amount: NaN
is: CHEBI:16126
type: Species
is: SBO:0000247
initial concentration: 1.0
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose

metaR FATP6t
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
product: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
name: fatty acid electroneutral transport
is version of: http://identifiers.org/ec-code/6.2.1.7
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110007#
reversible: true

metaR S6TASE3ly
reactant: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
is: SBO:0000176
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
is described by: ECO:0000000
product: MODEL1310110007#
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14

metaM na1 e
initial amount: NaN
name: Sodium
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: Na CHARGE: 1
constant: false
type: Species
has only substance units: false
is: C01330
is: CHEBI:4541
is: HMDB00588

metaM gal c
notes: FORMULA: C6H12O6 CHARGE: 0
is: HMDB00143
name: D-Galactose
is: C00124
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_b09e7522_9796_41c4_839a_cc69b4e9f2d0
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: _AI631997_1_m
has only substance units: false
is encoded by: hsa:AI631997
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_03dc58f0_58bd_4697_8576_3047ccb9a682
is encoded by: hsa:1103
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: CHAT
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: P28329

http://identifiers.org/biomodels.db/MODEL1310110007#_7f455ed8_7d5d_40a9_9980_256cbc17f4eb
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:R33828
initial concentration: NaN
type: Species
constant: false
name: _R33828_1_c

metaR RE1254C
kinetic law: MODEL1310110007#
type: Reaction
name: RE1254
product: MODEL1310110007#
is: SBO:0000176
reversible: true
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
is described by: ECO:0000000
fast: false

metaR XOL7AH2tm
product: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
name: lipid, flip-flop intracellular transport
reversible: true
kinetic law: MODEL1310110007#
fast: false
type: Reaction
reactant: MODEL1310110007#
is described by: ECO:0000000

metaM dnad c
is: HMDB01179
boundary condition: false
is: C00857
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
name: Deamino-NAD+
initial amount: NaN
constant: false
is: CHEBI:18304
type: Species
has only substance units: false

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaR r0596
modifier: MODEL1310110007#
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110007#
fast: false
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110007#

metaM Rtotal c
constant: false
is: HMDB01448
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:16189
initial amount: NaN
has only substance units: false
type: Species
name: R total
notes: FORMULA: CO2FULLR CHARGE: -1

metaM thyox L e
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: HMDB00248
name: L-thyroxine
is: SBO:0000247
is: CHEBI:18332
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_3cd0aaf1_aa9f_4a81_a4c5_67ae2cc45e6c
is encoded by: hsa:343
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: AQP8
constant: false
has only substance units: false
is: O94778
boundary condition: true

metaR r1364
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110007#
reversible: false
product: MODEL1310110007#
name: Vesicular transport
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110007#
fast: false

metaR H2O2tp
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
is: SBO:0000185
fast: false
product: MODEL1310110007#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110007#
type: Reaction
name: hydrogen peroxide peroxisomal transport via diffusion

metaM pmtcoa x
name: Palmitoyl-CoA (n-C16:0CoA)
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57379
constant: false
is: C00154
is: HMDB01338
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154

http://identifiers.org/biomodels.db/MODEL1310110007#_c2ba7443_015b_410d_8d4e_c5cd6bf51070
boundary condition: true
is: P32019
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:3633
initial amount: NaN
name: INPP5B
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_e35a8c3b_a387_496e_bff0_4ea1ff390882
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
name: DPM2
is encoded by: hsa:8818
initial amount: NaN
is: SBO:0000252
type: Species

metaM dopasf c
is: HMDB06275
type: Species
initial concentration: 1.0
name: dopamine 3-O-sulfate
is: CHEBI:37946
boundary condition: false
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM 56dura c
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:15901
initial concentration: 1.0
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
initial amount: NaN
is: HMDB00076
constant: false
name: 5,6-dihydrouracil
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_d1c86195_3847_4940_b40f_56a5821709e2
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
type: Species
name: DHCR7
initial concentration: NaN
is: Q9UBM7
is encoded by: hsa:1717
initial amount: NaN

metaR r0591
modifier: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110007#
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is: SBO:0000176
product: MODEL1310110007#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_0856d40c_349c_4556_ab17_4f0ac4d8b810
initial concentration: NaN
type: Species
constant: false
name: PCYT1B
is encoded by: hsa:9468
is: E9PD84
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_597e907a_e965_4a92_936d_280fe12210dc
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: _AI480132_1_c
has only substance units: false
constant: false
type: Species
is encoded by: hsa:AI480132
initial amount: NaN

metaM 4fumacac c
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB01268
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
is: CHEBI:18034
name: 4-fumarylacetoacetate(2-)
initial amount: NaN

metaM na1 c
boundary condition: false
is: HMDB00588
is: CHEBI:4541
name: Sodium
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: Na CHARGE: 1
constant: false
type: Species
is: C01330

metaM h m
initial amount: NaN
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
name: proton
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: SBO:0000247
is: C00080
has only substance units: false
type: Species
constant: false
boundary condition: false

metaR TRPt4
reversible: false
name: L-tryptophan transport in via sodium symport
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
type: Reaction
product: MODEL1310110007#
is described by: ECO:0000304
is: SBO:0000185
fast: false
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#

metaR RE2655R
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reactant: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#
fast: false
product: MODEL1310110007#
type: Reaction
is: SBO:0000176
name: RE2655

metaM gthox c
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: SBO:0000247
is: CHEBI:58297
is: C00127
constant: false
is: HMDB03337
name: Oxidized glutathione
initial concentration: 1.0

metaM r5p c
has only substance units: false
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:18189
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
is: HMDB00618
initial concentration: 1.0
name: alpha-D-Ribose 5-phosphate
is: C00117

http://identifiers.org/biomodels.db/MODEL1310110007#_8bb1dd4b_2089_423a_85fa_0658322705bb
is: P18405
initial concentration: NaN
name: SRD5A1
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:6715
constant: false

metaR GDPtg
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
name: GDP intracellular transport
reactant: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false

metaM nh4 m
initial amount: NaN
constant: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
name: Ammonium
has only substance units: false
is: C01342
type: Species
initial concentration: 1.0
is: CHEBI:28938
is: HMDB00051
boundary condition: false
is: SBO:0000247

metaR EX phyt LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phytanic acid exchange
type: Reaction

metaR r1581
reversible: true
type: Reaction
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_436bd49d_1a31_4f4b_9451_510fe7fe22e5
name: DPYSL3
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:1809
initial concentration: NaN
is: Q8IXW6

metaR HMGCOAtx
is: SBO:0000185
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
kinetic law: MODEL1310110007#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
reactant: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_69534161_7b9a_4b1f_a05c_5ec9ae5695d3
is: O95470
name: SGPL1
has only substance units: false
is encoded by: hsa:8879
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_be3785b9_7ada_49a5_8435_13135095e68e
is encoded by: hsa:AI924226
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: _AI924226_1_m
initial amount: NaN
constant: false
boundary condition: true
type: Species

metaR r0410
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110007#
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_9a0222d2_10a8_464b_af11_8c1e783bb657
boundary condition: true
constant: false
is encoded by: hsa:10020
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: B7Z428
name: GNE
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_f9ac5337_b656_47c3_9386_9191e41a83b3
type: Species
has only substance units: false
is: SBO:0000252
name: LDHAL6A
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q6ZMR3
constant: false
is encoded by: hsa:160287

metaR NDP10ex
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.6
fast: false
reversible: false
reactant: MODEL1310110007#
product: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
is: SBO:0000176
kinetic law: MODEL1310110007#
name: nucleoside-diphosphatase (IDP), extracellular
modifier: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_1df60bd7_8582_4c59_810d_34915e18b640
is encoded by: hsa:AI285872
name: _AI285872_1_c
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN

metaR r0590
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
is: SBO:0000176
product: MODEL1310110007#
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
type: Reaction
kinetic law: MODEL1310110007#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110007#
fast: false
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM CE4792 m
constant: false
is: CHEBI:57923
name: 3-oxo-cis-8-tetradecenoyl-CoA
initial concentration: 1.0
type: Species
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_cb02d002_e665_4ceb_90f3_21d8ce7f4bd4
is: SBO:0000252
name: _AI761708_1_m
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:AI761708
constant: false
initial concentration: NaN

metaR EX acmana LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-acetyl-D-mannosamine
type: Reaction

metaM sarcs c
is: CHEBI:3513
has only substance units: false
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0
constant: false
initial amount: NaN
name: Sarcosine
is: HMDB00271
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: C00213

metaM h l
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: "
is: C00080
is: CHEBI:24636
boundary condition: false
name: proton
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_a42d6f2f_35ed_4349_b623_86ceb8ef5db8
is encoded by: hsa:4967
is: SBO:0000252
is: Q02218
boundary condition: true
initial concentration: NaN
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: OGDH

metaM hista c
name: histamium
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: CHEBI:58432
is: HMDB00870
initial concentration: 1.0
constant: false
initial amount: NaN

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_63498677_483b_40c3_b08b_f2c9ef4a2f35
is encoded by: hsa:2222
is: P37268
type: Species
name: FDFT1
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR r1580
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110007#
product: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110007#
fast: false
is described by: ECO:0000000

metaM o2 n
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:15379
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
name: dioxygen

metaM glyclt x
is: HMDB00115
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
name: glycolate
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:29805
type: Species
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaM ksi deg29 l
name: keratan sulfate I, degradation product 29
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
is: CHEBI:12936
constant: false
is: HMDB00143
has only substance units: false

metaR KSII CORE4tly
name: keratan sulfate II (core 4) transport, extracellular to lysosome
reactant: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false

metaR ME2
is version of: http://identifiers.org/ec-code/1.1.1.40
modifier: MODEL1310110007#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4199.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:
name: malic enzyme (NADP)
is described by: ECO:0000000
kinetic law: MODEL1310110007#
reversible: false
type: Reaction
reactant: MODEL1310110007#
fast: false
product: MODEL1310110007#

metaR ADSL2
is version of: http://identifiers.org/ec-code/4.3.2.2
name: adenylosuccinate lyase
reversible: false
reactant: MODEL1310110007#
is: SBO:0000176
product: MODEL1310110007#
fast: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:

metaR ADRNt
is described by: ECO:0000000
product: MODEL1310110007#
is: SBO:0000185
name: fatty acid transport via diffusion
type: Reaction
kinetic law: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true

metaR ACACt2m
is described by: ECO:0000269
product: MODEL1310110007#
fast: false
modifier: MODEL1310110007#
name: Acetoacetate mitochondrial transport via H+ symport
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
reactant: MODEL1310110007#

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_17d64ac7_0d5f_408b_8a01_1ba69ca5336c
name: GSTZ1
is: O43708
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2954
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_d738cf6b_5395_4374_adf0_13009e68d7aa
boundary condition: true
name: ME2
has only substance units: false
is encoded by: hsa:4200
constant: false
type: Species
is: SBO:0000252
is: P23368
initial amount: NaN
initial concentration: NaN

metaR ALAtN1
reactant: MODEL1310110007#
is described by: ECO:0000269
kinetic law: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#
type: Reaction
reversible: true
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
fast: false
name: Alanine transport (Na, H coupled)

metaR EX doco13ac
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

metaR FAEL205
reactant: MODEL1310110007#
name: fatty-acyl-CoA elongation (n-C20:5CoA)
modifier: MODEL1310110007#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
product: MODEL1310110007#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110007#_e05ff2a4_1f21_4e66_84c7_b5519e9c3ef6
name: GALE
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: Q14376
is encoded by: hsa:2582
is: SBO:0000252
constant: false

metaM CE1926 e
has only substance units: false
type: Species
name: gama-carboxyethyl-hydroxychroman
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
constant: false
initial amount: NaN
boundary condition: false
is: HMDB00127
is: CHEBI:15748
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_ede4272f_bb2f_457f_b367_99dd40fb35b7
has only substance units: false
initial amount: NaN
is encoded by: hsa:2530
is: Q546E0
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: FUT8
constant: false
type: Species

metaR UMPKn
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reactant: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000269
name: UMP kinase, nuclear
reversible: true
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
fast: false
is: SBO:0000176
modifier: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_2a0baaf4_d4b8_46b3_bb5a_cc86838bd68c
is encoded by: hsa:5332
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: E2QRH8
name: PLCB4

metaR HMGLm
reversible: false
reactant: MODEL1310110007#
name: hydroxymethylglutaryl-CoA lyase
fast: false
is version of: http://identifiers.org/ec-code/4.1.3.4
type: Reaction
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
modifier: MODEL1310110007#
is described by: ECO:0000134

metaR NACHEX23ly
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110007#
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110007#
kinetic law: MODEL1310110007#

metaR PYK
reversible: false
is: SBO:0000176
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000134
type: Reaction
name: pyruvate kinase
fast: false
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.40
product: MODEL1310110007#

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaR GGH 10FTHF7GLUe
is described by: ECO:0000000
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110007#
type: Reaction
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
reversible: false
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_af50ed2d_96b6_4413_91bb_229b55847d93
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
name: CHKA
is: P35790
is encoded by: hsa:1119
boundary condition: true

metaM lanost r
is: SBO:0000247
type: Species
boundary condition: false
constant: false
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
is: HMDB01251
name: lanosterol
initial amount: NaN
is: CHEBI:16521
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_e0118cce_53a4_4874_b241_79f1e55fee95
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:AI191472
name: _AI191472_1_c
is: SBO:0000252

metaR r2532
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
reversible: true
type: Reaction

metaM aps c
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
type: Species
boundary condition: false
is: CHEBI:58243
constant: false
is: SBO:0000247
name: 5'-adenylyl sulfate(2-)
initial concentration: 1.0
is: HMDB01003

metaM methf c
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: HMDB01354
name: 5,10-Methenyltetrahydrofolate
has only substance units: false
is: SBO:0000247
is: C00445
initial amount: NaN
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: CHEBI:57455

metaR PI34P5K
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.68
product: MODEL1310110007#
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110007#
modifier: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
kinetic law: MODEL1310110007#

metaR LEUKTRA4t
product: MODEL1310110007#
is described by: ECO:0000269
kinetic law: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
reversible: true
is: SBO:0000185
fast: false
name: leukotriene A4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110007#_bb500f4e_667b_4d89_9557_a0786b77da0a
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: P14060
constant: false
initial amount: NaN
is encoded by: hsa:3283
name: HSD3B1
boundary condition: true

metaM gthox e
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
constant: false
is: CHEBI:58297
type: Species
is: HMDB03337
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_1c31114c_52a1_465c_ab57_7ee5fb6e6871
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:38
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: P24752
name: ACAT1

metaR TYMSFt
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
type: Reaction
reactant: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000
name: Tyramine O-sulfate transport (diffusion)

metaM crn m
type: Species
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
name: L-Carnitine
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00062
is: SBO:0000247
is: C00318
initial amount: NaN
has only substance units: false
is: CHEBI:16347

metaR ADSL1
modifier: MODEL1310110007#
is described by: ECO:0000269
reversible: false
product: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/4.3.2.2
name: adenylosuccinate lyase
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_513df7cf_9b02_408b_a9ed_5ce5169e7fa3
type: Species
initial concentration: NaN
is: Q6ZWP6
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:27034
name: ACAD8
has only substance units: false
constant: false

metaR FRDPtr
reversible: true
type: Reaction
kinetic law: MODEL1310110007#
is: SBO:0000185
reactant: MODEL1310110007#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
name: lipid, flip-flop intracellular transport
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_591b7076_0c34_40dd_ae75_1135ff98296a
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: P19961
constant: false
is encoded by: hsa:280
initial concentration: NaN
name: AMY2B

metaR GLCNACASE4ly
is: SBO:0000176
reactant: MODEL1310110007#
product: MODEL1310110007#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.50
reversible: false
kinetic law: MODEL1310110007#
type: Reaction
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
name: alpha-N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000

metaR LEUKTRB4t
fast: false
is: SBO:0000185
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
name: leukotriene B4 transport
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#

metaR CYOR u10m
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
is: SBO:0000185
modifier: MODEL1310110007#
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.2.1.3
name: ubiquinol-6 cytochrome c reductase, Complex III
reversible: false
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.5.1.92

http://identifiers.org/biomodels.db/MODEL1310110007#_69fd50d1_7647_4749_addf_67e8e7dcfa56
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is: C9JC79
name: SCP2
is encoded by: hsa:6342
initial amount: NaN
type: Species
constant: false

metaM CE5791 e
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C35H47N10O7 CHARGE: 1 INCHI: InChI=1/C35H46N10O7/c36-25(8-4-14-40-35(37)38)30(47)43-27(18-23-19-39-20-41-23)33(50)45-15-5-9-29(45)32(49)42-26(16-22-10-12-24(46)13-11-22)31(48)44-28(34(51)52)17-21-6-2-1-3-7-21/h1-3,6-7,10-13,19-20,25-29,46H,4-5,8-9,14-18,36H2,(H,39,41)(H,42,49)(H,43,47)(H,44,48)(H,51,52)(H4,37,38,40)/p+1/t25-,26-,27+,28+,29+/m1/s1 EHMN_ABBREVIATION: CE5791
type: Species
constant: false
is: HMDB02710
is: CHEBI:27485
name: kinetensin 4-8
boundary condition: false

metaM ksi deg21 l
is: SBO:0000247
is: CHEBI:12936
initial amount: NaN
constant: false
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
initial concentration: 1.0
is: HMDB00143
boundary condition: false
name: keratan sulfate I, degradation product 21
type: Species
has only substance units: false

metaM nh4 n
initial amount: NaN
is: HMDB00051
boundary condition: false
name: ammonium
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28938
constant: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaR DSREDUCr
is version of: http://identifiers.org/ec-code/1.3.1.72
reversible: false
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
is described by: ECO:0000134
reactant: MODEL1310110007#
fast: false
type: Reaction
name: Desmosterol reductase
product: MODEL1310110007#
is: SBO:0000176
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#

metaR FAEL204
modifier: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
fast: false
reversible: false
name: fatty-acyl-CoA elongation (n-C20:4CoA)
reactant: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ

http://identifiers.org/biomodels.db/MODEL1310110007#_bf57b42c_aacd_4d2b_84cd_04bc4eb85e3e
initial amount: NaN
boundary condition: true
is: P12235
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
name: SLC25A4
is encoded by: hsa:291

metaM 7thf e
notes: FORMULA: C49H57N13O24 CHARGE: -8
name: heptaglutamyl folate (THF)
constant: false
initial amount: NaN
has only substance units: false
is: HMDB06559
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM h n
type: Species
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial amount: NaN
initial concentration: 1.0
is: CHEBI:24636
is: SBO:0000247
boundary condition: false
name: proton
constant: false

metaM hista e
constant: false
name: histamium
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: CHEBI:58432
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00870
has only substance units: false
boundary condition: false

metaR NACHEX19ly
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
product: MODEL1310110007#
modifier: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.52

metaM HC02187 c
name: reverse-triiodthyronine
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
initial concentration: 1.0
is: CHEBI:28774
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_f9f75696_6697_484a_b49c_d8c986701c28
initial amount: NaN
is encoded by: hsa:AI656480
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: _AI656480_1_m
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_4fc5c161_f13e_4f8f_9e57_d4235336e932
is encoded by: hsa:4694
is: Q6IBB5
initial concentration: NaN
constant: false
boundary condition: true
name: NDUFA1
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species

metaM sarcs e
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
boundary condition: false
is: CHEBI:15611
type: Species
is: HMDB00271
constant: false
initial concentration: 1.0
has only substance units: false
name: sarcosine

http://identifiers.org/biomodels.db/MODEL1310110007#_ecfd81b0_b99c_4d35_b1b4_33948f4b2702
initial amount: NaN
name: CBS
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:875
constant: false
boundary condition: true
is: SBO:0000252
is: Q9NTF0

metaM 3mop c
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:28654
initial concentration: 1.0
type: Species
initial amount: NaN
name: 3-methyl-2-oxopentanoate
is: HMDB00491
constant: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671

metaM 44mctr r
is: HMDB01023
is: SBO:0000247
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
is: CHEBI:17813
initial amount: NaN
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false

metaR r0627
product: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
kinetic law: MODEL1310110007#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
type: Reaction
fast: false

metaR r2534
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true
type: Reaction

metaM HC00229 e
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
type: Species
is: CHEBI:28189
name: Isomaltose
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0

metaM phytcoa c
name: phytanoyl-CoA(4-)
is: CHEBI:57391
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
type: Species
is: HMDB01359
boundary condition: false
has only substance units: false

metaR FAOXC140
is: SBO:0000176
type: Reaction
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000269
product: MODEL1310110007#
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110007#_14e603ea_67b8_4bd5_b106_9c7ad2eb56d9
is: SBO:0000252
is encoded by: hsa:1491
constant: false
initial amount: NaN
type: Species
name: CTH
boundary condition: true
is: P32929
initial concentration: NaN
has only substance units: false

metaM idour e
boundary condition: false
initial concentration: 1.0
name: L-iduronate
is: CHEBI:21338
is: HMDB02704
type: Species
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_19184bd1_c8be_4336_9f8d_837b3756f468
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is: Q9NPB1
is encoded by: hsa:56953
boundary condition: true
name: NT5M

metaR r2090
reactant: MODEL1310110007#
reversible: true
product: MODEL1310110007#
type: Reaction
fast: false
kinetic law: MODEL1310110007#
is: SBO:0000185
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

metaM CE1944 c
type: Species
is: CHEBI:36781
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
name: 1-pyrrolinium
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944

metaR CYTK9n
type: Reaction
is described by: ECO:0000269
reversible: true
name: cytidylate kinase (CMP,dCTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110007#
fast: false

metaM HC02205 c
is: CHEBI:28099
initial concentration: 1.0
constant: false
name: prostaglandin-b2
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954

http://identifiers.org/biomodels.db/MODEL1310110007#_af5e367c_7cef_48fa_bb12_4a42a26bad1b
is encoded by: hsa:1644
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: Q53Y41
name: DDC

metaR S6TASE11ly
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110007#
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110007#
type: Reaction

metaR r1939
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110007#
reactant: MODEL1310110007#
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
name: Y+LAT2 Utilized transport
reversible: false

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

metaR r2535
fast: false
is described by: ECO:0000000
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true
type: Reaction
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000185

metaM trdrd c
is: CHEBI:15967
type: Species
is: C00342
name: Reduced thioredoxin
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN

metaR MANtg
fast: false
reversible: false
name: mannose efflux from Golgi apparatus
reactant: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110007#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_54eebb43_1ed2_438e_90fd_9c8082f9f5c9
name: PRPS1L1
initial amount: NaN
boundary condition: true
is encoded by: hsa:221823
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252

metaM pmtcoa r
is: SBO:0000247
has only substance units: false
constant: false
is: C00154
is: HMDB01338
initial amount: NaN
boundary condition: false
name: Palmitoyl-CoA (n-C16:0CoA)
initial concentration: 1.0
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: CHEBI:3454
type: Species

metaR GALASE15ly
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
product: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110007#
modifier: MODEL1310110007#
reversible: false
fast: false

metaM phaccoa c
initial concentration: 1.0
type: Species
has only substance units: false
name: phenylacetyl-CoA(4-)
is: CHEBI:57390
initial amount: NaN
is: HMDB06503
boundary condition: false
is: SBO:0000247
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
constant: false

metaR MALTSULtm
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110007#
is described by: ECO:0000269
modifier: MODEL1310110007#
reactant: MODEL1310110007#
name: Malate:thiosulfate antiport, mitochondrial
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110007#

metaR ASPPROASCT1
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
name: aspartate intake by system ASCT-1 transporter
product: MODEL1310110007#
reversible: false
is: SBO:0000185
is described by: ECO:0000134
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_79e54353_c45e_4ee9_98dc_f6bada7b20b7
has only substance units: false
type: Species
boundary condition: true
is: Q16718
is encoded by: hsa:4698
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: NDUFA5

metaM prostgi2 c
type: Species
is: CHEBI:57403
name: prostaglandin I2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: HMDB01335
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false

metaR r2091
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110007#
modifier: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_afb202af_983a_4b0c_a570_0b4bfee6f073
is encoded by: hsa:AI024818
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
name: _AI024818_1_c

metaR PECDCHe
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of pectins with deoxycholic acid in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR LCADi D
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.2.1.36
reversible: false
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000304
name: lactaldehyde dehydrogenase
is: SBO:0000176
product: MODEL1310110007#
fast: false
type: Reaction
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD

metaM lys L e
is: HMDB00182
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:32551
boundary condition: false
name: L-lysinium(1+)
initial amount: NaN
is: SBO:0000247

metaM pa hs c
is: CHEBI:57739
is: SBO:0000247
type: Species
initial amount: NaN
name: phosphatidate(2-)
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
boundary condition: false

metaR HSAT4ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
name: heparan-glucosaminide N-acetyltransferase, lysosomal
type: Reaction
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
product: MODEL1310110007#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_cdbe31ab_cedb_406a_bb0b_7d23bd458661
initial concentration: NaN
has only substance units: false
name: EARS2
type: Species
is: Q5JPH6
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:124454

metaR DOLPMT2 Ler
reversible: false
kinetic law: MODEL1310110007#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110007#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
is described by: ECO:0000000
fast: false
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:

metaR r0629
product: MODEL1310110007#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.4.1
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.6.1.22
is: SBO:0000176
modifier: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
fast: false
reactant: MODEL1310110007#

metaR CYTK1m
type: Reaction
product: MODEL1310110007#
reversible: true
fast: false
name: cytidylate kinase (CMP),mitochondrial
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion

metaM pail5p hs c
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57795
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
constant: false
type: Species
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)

metaR r0706
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
is version of: http://identifiers.org/ec-code/1.3.99.10
product: MODEL1310110007#
modifier: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6

metaR DNDPt28m
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110007#
name: dCDP transport via dGDP antiport
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
type: Reaction

metaR ACCOAC
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_b0f66108_1c82_4b41_9371_32297123ed68
type: Species
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:10317
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: B3GALT5

http://identifiers.org/biomodels.db/MODEL1310110007#_7337a701_5048_44b7_bae6_cb12e313deec
boundary condition: true
constant: false
is: SBO:0000252
name: PECR
initial concentration: NaN
type: Species
has only substance units: false
is: Q9BY49
is encoded by: hsa:55825
initial amount: NaN

metaR r0797
type: Reaction
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
fast: false
is: SBO:0000176
modifier: MODEL1310110007#
name: glycine N-choloyltransferase EC:2.3.1.65
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110007#

metaR r1871
type: Reaction
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
kinetic law: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110007#
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_f5e0ee5d_60ab_4eba_890b_8766b6ed06be
is encoded by: hsa:43
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species
name: ACHE

metaR NDP8ex
is: SBO:0000176
is described by: ECO:0000269
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.6
name: nucleoside-diphosphatase (UTP), extracellular
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
product: MODEL1310110007#
reactant: MODEL1310110007#
modifier: MODEL1310110007#
reversible: false
kinetic law: MODEL1310110007#

metaR DADAe
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.5.4.4
fast: false
is described by: ECO:0000269
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110007#
name: Deoxyadenosine deaminase, extracellular

metaM hs deg10 l
is: HMDB00127
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
name: heparan sulfate, degradation product 10
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
is: CHEBI:15748

http://identifiers.org/biomodels.db/MODEL1310110007#_f0f7cd50_ece4_4b6c_85e8_2a7900f30073
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:11001
is: O14975
type: Species
name: SLC27A2
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_40db9059_f9f7_4e69_93e3_6e85dd434244
constant: false
boundary condition: true
name: ACOT2
is: P49753
type: Species
initial concentration: NaN
is encoded by: hsa:10965
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_30f062a8_ea57_479e_98a4_ec66c093bd82
initial amount: NaN
is encoded by: hsa:5372
initial concentration: NaN
is: A8K003
is: SBO:0000252
type: Species
name: PMM1
has only substance units: false
boundary condition: true
constant: false

metaR ME2m
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110007#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
reactant: MODEL1310110007#
name: malic enzyme (NADP), mitochondrial
is version of: http://identifiers.org/ec-code/1.1.1.40
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.38
type: Reaction
product: MODEL1310110007#

metaR 3HKYNAKGAT
product: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.64
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
is described by: ECO:0000304
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.7
fast: false
is: SBO:0000176

metaM dag hs c
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
name: diglyceride
has only substance units: false
is: CHEBI:18035
initial concentration: 1.0
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false

metaR RE1897C
product: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
fast: false
reactant: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: RE1897

metaR RE3326M
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
fast: false
modifier: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.4.4
is: SBO:0000176
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000000
name: RE3326
reversible: true
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_3a1664ad_008b_4318_bcb7_94c1d70f7f27
initial amount: NaN
is: SBO:0000252
name: SHMT1
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:6470

metaR r2537
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
name: Utilized transport
fast: false
type: Reaction
reactant: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#

metaM crn r
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
constant: false
is: CHEBI:16347
initial amount: NaN
is: HMDB00062
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: (R)-carnitine
type: Species
boundary condition: false

metaR CYTK1n
kinetic law: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
is: SBO:0000176
name: cytidylate kinase (CMP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110007#
reactant: MODEL1310110007#

metaR ANDRSTRNtr
name: androsterone intracellular transport
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
product: MODEL1310110007#

metaR r1259
is: SBO:0000176
reversible: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
name: EC:6.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110007#

metaR RETI2
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
product: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110007#
fast: false
reversible: true
name: retinol isomerase (9-cis)

metaR DAGt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110007#
name: diacylglycerol transport
reactant: MODEL1310110007#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110007#

metaM lys L c
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
is: CHEBI:32551
is: SBO:0000247
is: HMDB00182
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
type: Species
name: L-lysinium(1+)

http://identifiers.org/biomodels.db/MODEL1310110007#_dce749ba_fabb_4afd_a4e8_b4e2dd5996a9
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q53FV7
name: CPT1B
has only substance units: false
is encoded by: hsa:1375
type: Species
constant: false
initial concentration: NaN

metaR r0796
is described by: ECO:0000000
reactant: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
is: SBO:0000176
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
fast: false
modifier: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_e1da02ab_253e_40ea_825e_89aeab705a0b
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI378339
is: SBO:0000252
name: _AI378339_1_m
boundary condition: true
type: Species
initial amount: NaN

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaM hmgcoa m
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial concentration: 1.0
has only substance units: false
is: HMDB01375
is: SBO:0000247
name: Hydroxymethylglutaryl-CoA
initial amount: NaN
is: CHEBI:15467
type: Species
constant: false
boundary condition: false

metaM prostgi2 e
boundary condition: false
type: Species
is: CHEBI:57403
has only substance units: false
is: HMDB01335
name: prostaglandin I2(1-)
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
constant: false
initial concentration: 1.0
initial amount: NaN

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR RTOTAL2FATPc
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_9d84b741_375a_49d8_a284_961ef43288bc
initial concentration: NaN
type: Species
constant: false
is: P43353
is encoded by: hsa:221
name: ALDH3B1
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true

metaM udpglcur r
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: C00167
name: UDP-D-glucuronate
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: HMDB00935
is: CHEBI:58052
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_2c7f7e03_db35_4a97_868b_79a85148cb57
is: P54750
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5136
constant: false
initial concentration: NaN
has only substance units: false
name: PDE1A
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_1540c1c2_0158_4001_8632_1b9bb1368936
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:4728
has only substance units: false
is: O00217
initial concentration: NaN
name: NDUFS8
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_bca5b66e_6c5e_4f8e_b112_a33dc3e43107
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q8TET4
is encoded by: hsa:2595
initial amount: NaN
has only substance units: false
name: GANC
type: Species

metaR r2095
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reactant: MODEL1310110007#
type: Reaction
modifier: MODEL1310110007#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
kinetic law: MODEL1310110007#
reversible: true
is described by: ECO:0000000

metaR r0926
name: Postulated transport reaction
product: MODEL1310110007#
reversible: false
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
type: Reaction

metaR RE2814R
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
name: RE2814
is: SBO:0000176
product: MODEL1310110007#

metaR Asn X Ser Thrtr
kinetic law: MODEL1310110007#
is described by: ECO:0000269
reactant: MODEL1310110007#
name: Asn-X-Ser/Thr transport (from ER to lysosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
is: SBO:0000185
reversible: true
type: Reaction
fast: false
product: MODEL1310110007#

metaM dd2coa x
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
name: trans-Dodec-2-enoyl-CoA
boundary condition: false
is: CHEBI:57330
is: HMDB03712

metaR r1147
fast: false
type: Reaction
product: MODEL1310110007#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
kinetic law: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110007#

metaR HMGCOASim
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
product: MODEL1310110007#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.3.10
type: Reaction
fast: false
name: Hydroxymethylglutaryl CoA synthase (ir)
modifier: MODEL1310110007#
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#

metaM nh4 e
initial amount: NaN
is: CHEBI:28938
name: ammonium
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00051
has only substance units: false
boundary condition: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
type: Species

metaM dag hs e
is: CHEBI:18035
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
is: SBO:0000247
name: diglyceride
constant: false
boundary condition: false

metaM fald c
initial amount: NaN
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
initial concentration: 1.0
is: HMDB01426
is: CHEBI:16842
type: Species
has only substance units: false
constant: false
boundary condition: false
name: formaldehyde
is: SBO:0000247

metaM hxan c
boundary condition: false
initial amount: NaN
is: C00262
is: HMDB00157
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: SBO:0000247
type: Species
initial concentration: 1.0
name: Hypoxanthine
constant: false
has only substance units: false
is: CHEBI:17368

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaR r0853
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
is: SBO:0000185
product: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
name: Facilitated diffusion
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110007#_d88b0025_89e7_48ff_ad8c_60e2066a0c00
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9167
name: COX7A2L
initial concentration: NaN
is: Q6FGA0
has only substance units: false

metaR SBT Dtde
is described by: ECO:0000134
fast: false
name: D-sorbitol transport, extracellular
reactant: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110007#
type: Reaction

metaR r2094
product: MODEL1310110007#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110007#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110007#

metaM acgam r
is: SBO:0000247
is: HMDB00215
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial amount: NaN
constant: false
type: Species
name: N-acetyl-D-glucosamine
is: CHEBI:17411
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM dadp n
name: dADP(3-)
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57667
constant: false
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB01508
boundary condition: false

metaR r2096
is: SBO:0000185
reactant: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110007#
reversible: true
is described by: ECO:0000000
product: MODEL1310110007#
modifier: MODEL1310110007#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110007#_9e6a9708_0f76_47de_abe9_4e2abbfd5a5d
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:AW277253
name: _AW277253_1_c
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_56a350cf_1374_450f_923c_035f27bfda9d
is: SBO:0000252
type: Species
constant: false
name: _AI345944_1_m
initial amount: NaN
is encoded by: hsa:AI345944
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_a1bb8518_7946_43de_8f86_8f6705884539
has only substance units: false
initial amount: NaN
is encoded by: hsa:10935
is: P30048
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
name: PRDX3

http://identifiers.org/biomodels.db/MODEL1310110007#_874599fa_6cf0_4e81_bde2_8c1d5fb77156
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:AI990637
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
name: _AI990637_1_x

metaM 1pyr5c m
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
initial concentration: 1.0
boundary condition: false
is: HMDB01301
constant: false
name: 1-Pyrroline-5-carboxylate
is: SBO:0000247
is: C03912
type: Species
is: CHEBI:15893

http://identifiers.org/biomodels.db/MODEL1310110007#_f5ea340d_085c_4a59_8643_d5d850cb6f77
name: UGP2
is encoded by: hsa:7360
constant: false
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM gly c
constant: false
is: HMDB00123
name: Glycine
has only substance units: false
is: C00037
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:3339
notes: FORMULA: C2H5NO2 CHARGE: 0
initial amount: NaN

metaR STS1
name: Steryl-sulfatase
is version of: http://identifiers.org/ec-code/3.1.6.2
type: Reaction
product: MODEL1310110007#
reversible: false
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ
kinetic law: MODEL1310110007#
is: SBO:0000176
reactant: MODEL1310110007#
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_401ae4de_81ed_4c8a_bb08_6d8a9ec0b03f
type: Species
name: NDUFA7
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4701
is: Q6FG42
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_c04b2529_6662_44db_a481_0ac1ae35ba8c
initial amount: NaN
constant: false
name: NDUFS6
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4726
type: Species
is: SBO:0000252
is: Q6IBC4

metaR A4GALTg
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
name: Lactosylceramide 4-alpha-galactosyltransferase
reactant: MODEL1310110007#
product: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.228
reversible: false
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_663c0b31_f2c6_44ee_94f4_f6c55462607d
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AI971036
name: _AI971036_1_x
initial concentration: NaN
is: SBO:0000252
constant: false

metaR FAOXC142C122m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

metaM dcyt e
is: CHEBI:15698
name: Deoxycytidine
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: C00881
boundary condition: false
constant: false
is: HMDB00014
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_62121d79_331c_48b6_bfd4_8d071476fb96
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:3158
boundary condition: true
is: P54868
name: HMGCS2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_30181ff3_a75a_47b4_80de_e8ce25270741
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
is: P00568
boundary condition: true
type: Species
name: AK1
is encoded by: hsa:203
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_b01320ad_a6d4_4c4d_9b0c_3aae1db67497
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: MLYCD
is: O95822
constant: false
boundary condition: true
is encoded by: hsa:23417
type: Species

metaM ak2lgchol hs e
has only substance units: false
boundary condition: false
constant: false
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
is: C04317
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6975
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
type: Species

metaR PSFLIPm
product: MODEL1310110007#
fast: false
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.3.1
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
name: phosphatidylserine flippase
reversible: false
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
is described by: ECO:0000269

metaM trdox c
type: Species
initial amount: NaN
is: C00343
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:18191
initial concentration: 1.0
name: Oxidized thioredoxin
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343

http://identifiers.org/biomodels.db/MODEL1310110007#_d82148d4_b506_400f_ab61_14542805b5c0
boundary condition: true
is encoded by: hsa:7378
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: UPP1

metaM h c
initial concentration: 1.0
boundary condition: false
is: C00080
notes: FORMULA: H CHARGE: 1 INCHI: "
initial amount: NaN
type: Species
is: CHEBI:24636
constant: false
name: proton
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false

metaM dadp m
initial concentration: 1.0
is: HMDB01508
initial amount: NaN
is: CHEBI:57667
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
name: dADP(3-)
type: Species
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206

metaR CYSTGL
reversible: false
fast: false
product: MODEL1310110007#
name: cystathionine g-lyase
is version of: http://identifiers.org/ec-code/4.4.1.1
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1491.1) or (1491.2) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.4.1.1 Confidence Level: 4 AUTHORS: PMID:10727430,PMID:15189131 NOTES:NCD
type: Reaction
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000176
reactant: MODEL1310110007#

metaR C3STDH1Pr
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
reversible: false
fast: false
reactant: MODEL1310110007#
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110007#
is: SBO:0000176
name: C-3 sterol dehydrogenase (4-methylzymosterol)
product: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.170

http://identifiers.org/biomodels.db/MODEL1310110007#_63321fe7_2477_4c38_ad1d_6b909fe61781
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
is: P14060
name: HSD3B1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3283

http://identifiers.org/biomodels.db/MODEL1310110007#_f2ee36dd_7ee8_4622_9eaf_0eef254b9af1
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: Q99755
name: PIP5K1A
constant: false
is encoded by: hsa:8394

metaM leuktrA4 e
name: leukotriene A4(1-)
has only substance units: false
constant: false
is: HMDB01337
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:57463
is: SBO:0000247
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909

http://identifiers.org/biomodels.db/MODEL1310110007#_1b3cafc3_4d11_4260_86ce_502a52c75cf6
is encoded by: hsa:AI971036
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
name: _AI971036_1_m
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_2e5d5266_37d4_41b4_8642_301c06d514d9
boundary condition: true
is: Q4G1C4
has only substance units: false
is encoded by: hsa:284273
constant: false
name: ZADH2
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN

metaM 3mop e
constant: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
is: HMDB00491
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:28654
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
initial concentration: 1.0

metaR FAOXC1811603m
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation fatty acid
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110007#
reversible: false
kinetic law: MODEL1310110007#
product: MODEL1310110007#

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaM HC02205 e
is: CHEBI:28099
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
initial amount: NaN
type: Species
initial concentration: 1.0
name: prostaglandin-b2
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false

metaR 3MOBte
reactant: MODEL1310110007#
name: Transport of 3-methyl-2-oxobutanoate
type: Reaction
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_1a36459c_32e7_436b_bde8_06ac7a4f6ec2
name: ITPKB
constant: false
is encoded by: hsa:3707
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is: P27987

metaM gtp c
is: CHEBI:37565
name: GTP
constant: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
is: C00044
initial concentration: 1.0
boundary condition: false
is: HMDB01273

http://identifiers.org/biomodels.db/MODEL1310110007#_d6350cd4_b66c_404d_8ddd_1fe00a1d8c49
has only substance units: false
is: SBO:0000252
is encoded by: hsa:80347
type: Species
boundary condition: true
name: COASY
initial concentration: NaN
is: Q13057
constant: false
initial amount: NaN

metaR NODe
product: MODEL1310110007#
is described by: ECO:0000134
name: NODe
kinetic law: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true

metaR r2092
is described by: ECO:0000000
reactant: MODEL1310110007#
product: MODEL1310110007#
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110007#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is: SBO:0000185
fast: false
reversible: true

metaM dsmsterol r
is: HMDB02719
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
name: desmosterol
is: CHEBI:17737
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
initial concentration: 1.0

metaM ksi deg37 l
has only substance units: false
is: SBO:0000247
is: CHEBI:16953
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00812
name: keratan sulfate I, degradation product 37
type: Species
constant: false
notes: FORMULA: C62H104N4O46 CHARGE: 0

metaR HMGCOAtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110007#
fast: false
is: SBO:0000185
product: MODEL1310110007#
type: Reaction
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
kinetic law: MODEL1310110007#
reversible: true

metaM l2fn2m2masn g
is: SBO:0000247
constant: false
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
is: CHEBI:28067
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C68H113N4O49X CHARGE: 0

metaM o2 x
is: HMDB01377
type: Species
is: CHEBI:15379
has only substance units: false
is: C00007
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
constant: false
name: O2
boundary condition: false
initial concentration: 1.0

metaM ksi deg34 l
constant: false
type: Species
boundary condition: false
is: SBO:0000247
name: keratan sulfate I, degradation product 34
is: HMDB00812
is: CHEBI:16953
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C76H126N5O59S1 CHARGE: -1

metaR RE1826C
type: Reaction
reversible: false
is: SBO:0000176
name: RE1826
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110007#
kinetic law: MODEL1310110007#

metaR ILETA
modifier: MODEL1310110007#
name: isoleucine transaminase
product: MODEL1310110007#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110007#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
type: Reaction

metaR r2420
type: Reaction
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
fast: false
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110007#

metaM pail hs n
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:57880
name: 1-phosphatidyl-1D-myo-inositol(1-)
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
constant: false
is: SBO:0000247

metaR r1148
reactant: MODEL1310110007#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110007#
is: SBO:0000185
type: Reaction
name: Active transport
is described by: ECO:0000000
product: MODEL1310110007#

metaM C05280 m
type: Species
is: SBO:0000247
initial amount: NaN
name: cis,cis-3,6-Dodecadienoyl-CoA
has only substance units: false
is: CHEBI:28002
constant: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
is: HMDB03952
initial concentration: 1.0
boundary condition: false

metaR LYSOXp
is: SBO:0000176
product: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
name: L-lysine oxidase, peroxisomal
fast: false
type: Reaction
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_e73853b7_b1eb_4713_85e1_fcbb4fa4be78
name: SLC27A1
is encoded by: hsa:376497
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false

metaM 1pipdn2c x
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
name: 1-piperideine-2-carboxylate
is: HMDB01084
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:16187

http://identifiers.org/biomodels.db/MODEL1310110007#_50e280a6_1c58_4236_9859_242a4c59a4f5
type: Species
is encoded by: hsa:U37519
has only substance units: false
initial amount: NaN
boundary condition: true
name: _U37519_1_c
constant: false
is: SBO:0000252
initial concentration: NaN

metaM 34dhpha c
is: HMDB01336
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:17612
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
constant: false
boundary condition: false
is: SBO:0000247
type: Species
name: (3,4-dihydroxyphenyl)acetate

metaM gly e
boundary condition: false
is: C00037
notes: FORMULA: C2H5NO2 CHARGE: 0
name: Glycine
constant: false
initial concentration: 1.0
is: CHEBI:3339
initial amount: NaN
is: SBO:0000247
is: HMDB00123
type: Species
has only substance units: false

metaM sarcs m
initial amount: NaN
is: CHEBI:15611
is: C00213
is: HMDB00271
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
has only substance units: false
boundary condition: false
name: Sarcosine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_2e56b7c2_fdb5_4faf_ae8f_f313bed82de4
name: GCAT
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:23464
is: E2QC23
initial amount: NaN
type: Species

metaM ametam c
type: Species
is: C01137
is: SBO:0000247
is: CHEBI:57443
name: S-Adenosylmethioninamine
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00988
initial concentration: 1.0
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_a1a589ba_6672_42fd_b6d2_18ef434fb97d
initial amount: NaN
constant: false
boundary condition: true
is: Q9P0Z9
is: SBO:0000252
name: PIPOX
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:51268

metaM dcyt c
is: HMDB00014
is: CHEBI:15698
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: SBO:0000247
boundary condition: false
has only substance units: false
is: C00881
constant: false
name: Deoxycytidine

http://identifiers.org/biomodels.db/MODEL1310110007#_741d939c_49d3_4b8d_a2cf_1b13397294be
is encoded by: hsa:1374
constant: false
name: CPT1A
is: Q8WZ48
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR ORNDC
fast: false
reactant: MODEL1310110007#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.17
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (4953.1) SUBSYSTEM: Urea cycle EC Number: 4.1.1.17 Confidence Level: 4 AUTHORS: PMID:2317811 NOTES:JLR- added proton to balance
name: Ornithine Decarboxylase

metaM ksi e
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:17268
is: HMDB00211
is: SBO:0000247
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
name: keratan sulfate I
initial amount: NaN

metaR r2093
reversible: true
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110007#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_e291e41c_9388_4d1a_aa5e_e0adb7e4fde4
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:30
is: Q96CA6
name: ACAA1

http://identifiers.org/biomodels.db/MODEL1310110007#_3708926c_8cbd_42ce_bd66_cbc6229e7623
initial amount: NaN
is: P00326
type: Species
is: SBO:0000252
is encoded by: hsa:126
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
name: ADH1C

metaM HC00319 m
is: SBO:0000247
type: Species
has only substance units: false
name: Malonate
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:30794
initial amount: NaN

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaM glcur r
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:15748
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: HMDB00127
type: Species
initial concentration: 1.0
name: D-glucuronate
boundary condition: false

metaM h e
is: http://identifiers.org/pubchem.compound/3380
initial concentration: 1.0
initial amount: NaN
is: C00080
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: "
has only substance units: false
type: Species
constant: false
is: CHEBI:24636
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_e34133fa_d31e_4d81_a41a_f00ab6ecf3fe
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:6524
type: Species
initial concentration: NaN
is: P31639
has only substance units: false
name: SLC5A2
constant: false

metaR FUCtly
name: L-fucose efflux from lysosome
is described by: ECO:0000000
kinetic law: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
reactant: MODEL1310110007#
type: Reaction
is: SBO:0000185
reversible: false
fast: false

metaR OLEICFATPtc
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

metaM cgly c
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00078
initial concentration: 1.0
constant: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
is: CHEBI:4047
name: L-cysteinylglycine
initial amount: NaN
type: Species

metaR CYTK11n
name: cytidylate kinase (dCMP,dGTP),nuclear
reactant: MODEL1310110007#
fast: false
product: MODEL1310110007#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110007#
reversible: true
type: Reaction
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110007#_9f60be48_7d8b_4c2d_983b_1833158f0bce
is: SBO:0000252
initial concentration: NaN
is: Q6FGQ4
is encoded by: hsa:5538
boundary condition: true
name: PPT1
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaR NAGA2ly
name: N-acetylgalactosaminidase, alpha-
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
reactant: MODEL1310110007#
reversible: false
fast: false
type: Reaction
product: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.49
modifier: MODEL1310110007#
is described by: ECO:0000000

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaR STRDNCt
fast: false
product: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
name: fatty acid transport via diffusion
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110007#_a558adb9_38eb_45a2_b608_6f1914f97c5d
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:55089
initial amount: NaN
is: Q969I6
name: SLC38A4

http://identifiers.org/biomodels.db/MODEL1310110007#_7365c44b_aa83_40cd_969b_c733b567e156
is: SBO:0000252
initial amount: NaN
type: Species
name: SYNJ2
boundary condition: true
is: O15056
constant: false
has only substance units: false
is encoded by: hsa:8871
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_676c1b1e_1915_43e2_bc2b_46ea3139aee9
type: Species
initial amount: NaN
name: HAL
is encoded by: hsa:3034
is: B4E0V8
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_dea73ac6_75ac_4f3f_b207_c27f5a77689b
has only substance units: false
constant: false
name: SOD2
initial amount: NaN
is: P04179
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:6648

metaR r1156
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
product: MODEL1310110007#
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110007#

metaR r0913
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
product: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110007#
fast: false
reversible: true
is described by: ECO:0000000

metaR D LACt2
kinetic law: MODEL1310110007#
product: MODEL1310110007#
name: D-lactate transport via proton symport
is: SBO:0000185
fast: false
reactant: MODEL1310110007#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
reversible: true

metaM orn m
is: CHEBI:46912
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C5H13N2O2 CHARGE: 1
boundary condition: false
is: HMDB00214
is: C01602
name: Ornithine
has only substance units: false
is: SBO:0000247

metaR PROSTGI2tr
kinetic law: MODEL1310110007#
is described by: ECO:0000269
product: MODEL1310110007#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
fast: false
name: Prostaglandin I2 transport (ER)
reversible: true
reactant: MODEL1310110007#

metaM grdp x
type: Species
is: CHEBI:58057
name: geranyl diphosphate(3-)
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB01285
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_54796b07_11c1_4a39_8f95_31bb0dcd6444
is: SBO:0000252
is encoded by: hsa:7001
initial amount: NaN
type: Species
name: PRDX2
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN

metaR EX thym LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymine exchange
type: Reaction

metaM fadh2 m
initial amount: NaN
name: Flavin adenine dinucleotide reduced
type: Species
is: C01352
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB01197
initial concentration: 1.0
boundary condition: false
is: CHEBI:58307

metaR EX CE1943 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermidine dialdehyde exchange
type: Reaction

metaM pa hs m
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:57739
type: Species
name: phosphatidate(2-)
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416

http://identifiers.org/biomodels.db/MODEL1310110007#_fdd7c212_e593_46a3_b829_c81c3d8334eb
is: SBO:0000252
type: Species
is encoded by: hsa:D87002
boundary condition: true
name: _D87002_1_e
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false

metaR r0130
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
fast: false
type: Reaction
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
modifier: MODEL1310110007#
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
product: MODEL1310110007#

metaM acac m
is: SBO:0000247
is: CHEBI:13705
initial amount: NaN
type: Species
is: HMDB00060
name: acetoacetate
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_7ab1995c_d70c_4ad4_b22f_08b431484b22
is encoded by: hsa:7264
is: SBO:0000252
is: Q13630
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
constant: false
name: TSTA3

http://identifiers.org/biomodels.db/MODEL1310110007#_16ab374d_8f5f_4038_a514_1593eb426ed6
has only substance units: false
is: Q15735
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: INPP5J
initial concentration: NaN
type: Species
is encoded by: hsa:27124

metaR EX srtn LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Serotonin exchange
type: Reaction

metaR CDIPTr
name: phosphatidylinositol synthase (Homo sapiens)
is version of: http://identifiers.org/ec-code/2.7.8.11
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
reversible: true
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000
modifier: MODEL1310110007#
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110007#

metaR RE3346C
product: MODEL1310110007#
is: SBO:0000176
reactant: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
fast: false
kinetic law: MODEL1310110007#
is described by: ECO:0000000
modifier: MODEL1310110007#
name: RE3346

metaM glcur e
is: SBO:0000247
type: Species
constant: false
boundary condition: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial concentration: 1.0
is: HMDB00127
name: D-glucuronate
has only substance units: false
is: CHEBI:15748
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_57da8d22_2471_45b7_8647_03bccd79bcad
has only substance units: false
is encoded by: hsa:790
name: CAD
is: SBO:0000252
initial amount: NaN
is: P27708
boundary condition: true
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_b647d063_07d1_4934_89b4_978aa9a37100
is: SBO:0000252
constant: false
name: SLC16A3
has only substance units: false
is encoded by: hsa:9123
initial concentration: NaN
is: O15427
initial amount: NaN
type: Species
boundary condition: true

metaM lthstrl r
boundary condition: false
has only substance units: false
is: CHEBI:17168
constant: false
initial amount: NaN
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB01170
name: 5alpha-cholest-7-en-3beta-ol

metaM prpp e
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
constant: false
is: CHEBI:58017
boundary condition: false
is: HMDB00280

metaM acn13acngalgbside hs g
has only substance units: false
constant: false
is: CHEBI:3338
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: C00036
initial concentration: 1.0
is: HMDB00223
initial amount: NaN
name: sialyl (1,3) sialyl (2,6) galactosylgloboside
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_8f9a157f_dfe1_4698_bdc6_977589f8bdbf
is encoded by: hsa:218
initial concentration: NaN
boundary condition: true
name: ALDH3A1
is: SBO:0000252
type: Species
is: P30838
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_1066b4a7_ca0c_4e82_bc39_e9944291b1ae
is: SBO:0000252
is: Q96CD2
initial amount: NaN
is encoded by: hsa:60490
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false
name: PPCDC

http://identifiers.org/biomodels.db/MODEL1310110007#_1b1170a8_0123_41c4_8f4b_dbd56c0dc7ee
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
constant: false
name: COX4I2
is encoded by: hsa:84701
is: Q96KJ9

metaR PGSr
product: MODEL1310110007#
type: Reaction
name: Prostaglandin G/H synthase
reversible: false
notes: GENE_ASSOCIATION: (5743.1) or (5742.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 4 AUTHORS: PMID:14511332,PMID:1907252 NOTES:NJ
is version of: http://identifiers.org/ec-code/1.14.99.1
reactant: MODEL1310110007#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110007#
fast: false
modifier: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_56823bf8_c518_40e8_8bc4_6ec667fbfdb8
is: SBO:0000252
is: O95573
initial amount: NaN
constant: false
boundary condition: true
type: Species
name: ACSL3
initial concentration: NaN
is encoded by: hsa:2181
has only substance units: false

metaM fad m
initial concentration: 1.0
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
name: Flavin adenine dinucleotide oxidized
has only substance units: false
boundary condition: false
is: C00016
initial amount: NaN
is: HMDB01248
is: CHEBI:16238
type: Species
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_8e01fbfb_759a_4045_888c_57221366118a
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:7378
is: Q16831
name: UPP1
has only substance units: false
type: Species

metaR NACHEX12ly
product: MODEL1310110007#
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110007#

metaM lac L c
name: (S)-lactate
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:16651
is: SBO:0000247
constant: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: HMDB00190

http://identifiers.org/biomodels.db/MODEL1310110007#_eb5c9ee8_7014_4f01_9e93_7a72ec553697
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
name: ESPN
initial concentration: NaN
is encoded by: hsa:83715
boundary condition: true
is: B1AK53

metaM CE4790 m
constant: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
initial amount: NaN
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:57923
type: Species
is: SBO:0000247

metaR BILDGLCURt
product: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
type: Reaction
reversible: true
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
reactant: MODEL1310110007#

metaR r2519
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
is: SBO:0000185
product: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
name: Utilized transport

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaR ADA
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.4.4
name: Adenosine deaminase
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
reactant: MODEL1310110007#
product: MODEL1310110007#
modifier: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110007#_6964a62d_7469_4c20_8c1f_b62a689089c2
type: Species
initial concentration: NaN
is: P61457
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5092
constant: false
initial amount: NaN
boundary condition: true
name: PCBD1

metaM HC02121 c
name: S-(hydroxymethyl)glutathione(1-)
initial concentration: 1.0
type: Species
is: CHEBI:58758
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
has only substance units: false

metaR UMPK7
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110007#
reactant: MODEL1310110007#
name: UMP kinase (dGTP)
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true

metaM cgly e
is: HMDB00078
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:4047
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
initial amount: NaN
name: L-cysteinylglycine
type: Species
is: SBO:0000247

metaR FAOXC163GC142m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaR r0911
reactant: MODEL1310110007#
is described by: ECO:0000000
name: Facilitated diffusion
fast: false
kinetic law: MODEL1310110007#
reversible: true
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
is: SBO:0000185
type: Reaction

metaM leuktrD4 e
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: SBO:0000247
constant: false
boundary condition: false
name: Leukotriene D4
is: HMDB03080
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:28666

metaM pan4p m
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: HMDB01416
is: SBO:0000247
constant: false
is: CHEBI:47942
boundary condition: false
type: Species
initial concentration: 1.0
name: pantetheine 4'-phosphate(2-)
has only substance units: false
initial amount: NaN

metaR PI45PLC
modifier: MODEL1310110007#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.4.11
is described by: ECO:0000000
kinetic law: MODEL1310110007#
fast: false
product: MODEL1310110007#
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
type: Reaction
reactant: MODEL1310110007#

metaM gua c
is: HMDB00132
is: C00242
is: CHEBI:16235
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
name: Guanine

metaR MCLOR
product: MODEL1310110007#
name: 3-Mercaptolactate:NAD+ oxidoreductase
is described by: ECO:0000269
reactant: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.27

metaR MCLACCYSR
type: Reaction
product: MODEL1310110007#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
is described by: ECO:0000000
name: 3-mercaptolactate:cysteine reductase
reversible: false
fast: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#

metaR OBDHc
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.7.2 Confidence Level: 2 AUTHORS: NOTES:as shown in Lehninger (4th ed.) for threonine degradation MM
type: Reaction
reversible: false
is: SBO:0000176
name: 2-Oxobutanoate dehydrogenase, cytosolic
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110007#

metaR r1154
reactant: MODEL1310110007#
product: MODEL1310110007#
name: EC:1.2.7.2
reversible: true
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
type: Reaction
kinetic law: MODEL1310110007#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_08ab5e59_8fc2_43d5_b229_87bc38c47eb1
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: _H17063_1_m
is encoded by: hsa:H17063
initial concentration: NaN
type: Species

metaM crn x
is: C00318
has only substance units: false
type: Species
name: L-Carnitine
initial concentration: 1.0
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
constant: false
is: SBO:0000247
is: HMDB00062
boundary condition: false
is: CHEBI:16347
initial amount: NaN

metaR DOLPMT L
is described by: ECO:0000000
reactant: MODEL1310110007#
product: MODEL1310110007#
type: Reaction
fast: false
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.83
name: Dolichyl-phosphate D-mannosyltransferase (liver)

metaM lac L e
is: CHEBI:16651
constant: false
initial amount: NaN
is: SBO:0000247
name: (S)-lactate
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: HMDB00190

http://identifiers.org/biomodels.db/MODEL1310110007#_a478017f_ebef_4993_be46_4dd65cee651f
is: SBO:0000252
name: AMPD2
is encoded by: hsa:271
boundary condition: true
is: E9PNG0
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR FK
is: SBO:0000176
is described by: ECO:0000000
reversible: false
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.1.52
name: Fucokinase
fast: false
reactant: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#

metaM gtp e
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:37565
name: GTP(4-)
initial amount: NaN
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
type: Species
is: HMDB01273
has only substance units: false

metaR UMPK6
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110007#
name: UMP kinase (dCTP)
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110007#
reversible: true
is described by: ECO:0000269

metaR RE1709N
is version of: http://identifiers.org/ec-code/4.2.1.96
modifier: MODEL1310110007#
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110007#
name: RE1709
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110007#

metaM prpp c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: SBO:0000247
name: 5-Phospho-alpha-D-ribose 1-diphosphate
initial amount: NaN
type: Species
is: CHEBI:58017
constant: false
is: C00119
boundary condition: false
is: HMDB00280

http://identifiers.org/biomodels.db/MODEL1310110007#_25f69609_0321_4d84_a0e3_28fe3f60850b
initial amount: NaN
is encoded by: hsa:220
is: SBO:0000252
is: P47895
constant: false
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
name: ALDH1A3

metaR B MANNASEly
is: SBO:0000176
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
reactant: MODEL1310110007#
name: beta-mannosidase, lysosomal
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.25
type: Reaction
product: MODEL1310110007#
reversible: false
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_15d6e2b3_4ba5_44d2_af50_a1a8ddc7e9c6
is encoded by: hsa:8898
type: Species
name: MTMR2
initial concentration: NaN
constant: false
is: SBO:0000252
is: A6NN98
boundary condition: true
has only substance units: false
initial amount: NaN

metaM HC00591 m
constant: false
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:16769
initial amount: NaN
initial concentration: 1.0
name: 2-oxoglutaramate
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940

metaR DURIK1
type: Reaction
is: SBO:0000176
product: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:
modifier: MODEL1310110007#
is described by: ECO:0000254
reactant: MODEL1310110007#
name: deoxyuridine kinase (ATP:Deoxyuridine)
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.21

metaM tdcoa m
is: HMDB01521
type: Species
name: Tetradecanoyl-CoA (n-C14:0CoA)
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
boundary condition: false
is: CHEBI:57385
is: SBO:0000247
constant: false
is: C02593

http://identifiers.org/biomodels.db/MODEL1310110007#_c94bcc4d_a9ec_48b8_b106_cebc7aadd8ad
initial concentration: NaN
is: Q9BWD1
type: Species
boundary condition: true
initial amount: NaN
name: ACAT2
has only substance units: false
constant: false
is encoded by: hsa:39
is: SBO:0000252

metaM HC01603 c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
initial amount: NaN
type: Species
is: C00234
name: 10-Formyltetrahydrofolate
initial concentration: 1.0
is: CHEBI:57454
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_1497c162_0870_40c0_a846_35285f7de8df
is: B2RAT6
name: GALT
is encoded by: hsa:2592
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN

metaM 5mdru1p c
is: SBO:0000247
is: HMDB01299
notes: FORMULA: C6H11O7PS CHARGE: -2
is: C04582
name: 5-Methylthio-5-deoxy-D-ribulose 1-phosphate
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: CHEBI:58548

metaM udpacgal g
boundary condition: false
constant: false
initial amount: NaN
name: UDP-N-acetyl-D-galactosamine(2-)
type: Species
is: CHEBI:57847
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: HMDB00304

metaM leuktrD4 c
is: CHEBI:28666
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB03080
initial amount: NaN
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
type: Species
boundary condition: false
name: Leukotriene D4

metaR EX adprbp LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ADPribose 2'-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_fe7cca41_f407_45a7_8d54_916462e76e54
is encoded by: hsa:9365
boundary condition: true
constant: false
initial concentration: NaN
type: Species
name: KL
initial amount: NaN
has only substance units: false
is: Q9UEF7
is: SBO:0000252

metaM pail5p hs n
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: CHEBI:57795

metaR ASNtN1
product: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269
kinetic law: MODEL1310110007#
name: Asparagine transport (Na, H coupled)
is: SBO:0000185
reversible: true
reactant: MODEL1310110007#
fast: false
modifier: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_801551bc_da7f_434f_b928_bd156a48f4d3
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is: B3KUK6
initial concentration: NaN
name: NT5C1B
has only substance units: false
is encoded by: hsa:93034

metaM mn l
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB06535
name: beta-1,4-mannose-N-acetylglucosamine

http://identifiers.org/biomodels.db/MODEL1310110007#_35d4b89e_51e4_45db_ae6b_027b39949895
is: Q9Y2Q0
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: ATP8A1
is encoded by: hsa:10396
constant: false
boundary condition: true
type: Species
has only substance units: false

metaR LNLCCPT2
is described by: ECO:0000000
fast: false
product: MODEL1310110007#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110007#
is: SBO:0000176
reactant: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
kinetic law: MODEL1310110007#

metaM acgam6p c
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:57513
type: Species
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
is: HMDB01062
name: N-acetyl-D-glucosamine 6-phosphate(2-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_d0620e99_37f3_40d1_b767_d0d2f0785897
boundary condition: true
is: SBO:0000252
is encoded by: hsa:79646
type: Species
initial amount: NaN
is: Q9H999
name: PANK3
initial concentration: NaN
has only substance units: false
constant: false

metaR RE2660C
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000
name: RE2660
is: SBO:0000176
type: Reaction
reactant: MODEL1310110007#

metaR GLCter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
product: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
name: glucose transport, endoplasmic reticulum
reactant: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_5989885a_a1e9_4af6_85d2_2dce4e316cb2
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
name: _R51273_1_c
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:R51273

metaM lnlnca c
type: Species
initial concentration: 1.0
is: SBO:0000247
name: alpha-linolenate
constant: false
is: CHEBI:32387
has only substance units: false
initial amount: NaN
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
boundary condition: false
is: HMDB01388

http://identifiers.org/biomodels.db/MODEL1310110007#_4ccbcdc8_296f_4770_a69e_c9ae3de847a8
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4696
boundary condition: true
initial concentration: NaN
name: NDUFA3
type: Species
is: O95167

metaM trp L e
is: CHEBI:16828
initial amount: NaN
type: Species
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: HMDB00929
has only substance units: false
name: L-tryptophan
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_36779909_cfb9_4dcb_9e0e_0192b8c07dcd
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
constant: false
name: _H17063_1_c
has only substance units: false
is encoded by: hsa:H17063

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_c8e8d74f_a632_43d3_a295_e949129f1b88
type: Species
constant: false
boundary condition: true
name: SOD1
initial amount: NaN
is: P00441
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6647

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

metaR CO2t
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
reversible: true
product: MODEL1310110007#
is: SBO:0000185
name: CO2 transporter via diffusion

metaM HC02179 c
name: 20-hydroxy-arachidonate
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:34306
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
boundary condition: false

metaM 3mop m
name: 3-methyl-2-oxopentanoate
type: Species
initial amount: NaN
is: CHEBI:28654
has only substance units: false
initial concentration: 1.0
is: HMDB00491
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_d27f72ef_d3a3_49bb_a9ba_451bf24daffd
constant: false
initial amount: NaN
is: Q96DU7
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:80271
name: ITPKC
type: Species

metaM damp c
has only substance units: false
type: Species
is: HMDB00905
initial concentration: 1.0
initial amount: NaN
name: dAMP(2-)
is: SBO:0000247
is: CHEBI:58245
boundary condition: false
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
constant: false

metaR ILEt4
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
reversible: false
modifier: MODEL1310110007#
is: SBO:0000185
fast: false
is described by: ECO:0000304
name: L-isoleucine transport in via sodium symport
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
product: MODEL1310110007#

metaR LNLCCPT1
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
name: carnitine O-palmitoyltransferase
fast: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110007#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110007#_710e1d6a_5ead_4cb6_b0ff_b2716b866a56
initial concentration: NaN
initial amount: NaN
is: P31937
has only substance units: false
name: HIBADH
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:11112

http://identifiers.org/biomodels.db/MODEL1310110007#_479c3a9f_3ec4_4060_a7ce_788a17680116
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is: Q16773
type: Species
name: CCBL1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:883

metaM mercplac c
constant: false
name: 3-Mercaptolactate
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
is: C05823
is: http://identifiers.org/pubchem.compound/8118
is: HMDB02127
boundary condition: false
type: Species

metaR r1260
name: EC:6.2.1.3
product: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110007#
reversible: false
is: SBO:0000176
reactant: MODEL1310110007#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_d8f4d7b6_142d_4532_b873_5497a3b2326b
constant: false
is encoded by: hsa:F23536
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
name: _F23536_1_m

metaM tyr L c
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
name: L-tyrosine
has only substance units: false
is: CHEBI:17895
initial concentration: 1.0
is: HMDB00158
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_60d11bc9_ae1d_4be1_88cd_e5a23a55a8f9
is: Q96C36
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
name: PYCR2
is encoded by: hsa:29920
initial amount: NaN

metaM dcsptn1crn m
boundary condition: false
is: HMDB06321
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
constant: false
name: docosa-4,7,10,13,16-pentaenoyl carnitine

metaR r2399
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110007#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110007#
is: SBO:0000185
reactant: MODEL1310110007#

metaR SUCCtp
name: succinate transporter, peroxisome
type: Reaction
is described by: ECO:0000000
product: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
reactant: MODEL1310110007#
reversible: true
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110007#_efcba767_75e6_4b50_817c_050dd9871876
boundary condition: true
constant: false
name: ALAS1
is encoded by: hsa:211
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: Q5JAM2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_d5f24998_fbe9_40df_9917_36bbebe13b82
constant: false
is: P24310
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
name: COX7A1
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1346

metaM glcur l
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:15748
is: HMDB00127
name: D-glucuronate
boundary condition: false
type: Species
constant: false

metaR r2309
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaM ksi deg24 l
is: SBO:0000247
is: CHEBI:12936
name: keratan sulfate I, degradation product 24
constant: false
is: HMDB00143
boundary condition: false
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_3b988012_67d9_4fbb_bbfa_db14c3a7748d
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:85365
name: ALG2
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN

metaR CSNAT2x
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.7
kinetic law: MODEL1310110007#
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
reactant: MODEL1310110007#
product: MODEL1310110007#
fast: false
is: SBO:0000176
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.137
modifier: MODEL1310110007#

metaR RDH3a
kinetic law: MODEL1310110007#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.105
type: Reaction
reversible: true
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.300
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
modifier: MODEL1310110007#
reactant: MODEL1310110007#
name: retinol dehydrogenase (11-cis,NADPH)

metaR RE1530C
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
kinetic law: MODEL1310110007#
type: Reaction
name: RE1530
product: MODEL1310110007#
is described by: ECO:0000000
reactant: MODEL1310110007#
fast: false
is: SBO:0000176
reversible: true

metaR BILIRUBt2
type: Reaction
is: SBO:0000185
reactant: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110007#
reversible: true
is described by: ECO:0000269
name: bilirubin transport via bicarbonate countertransport
fast: false
modifier: MODEL1310110007#

metaR 3HCO3 NAt
reactant: MODEL1310110007#
name: 3HCO3_NAt
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
reversible: true
is: SBO:0000185
fast: false
type: Reaction

metaM trp L c
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00929
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
has only substance units: false
is: CHEBI:16828
type: Species
initial concentration: 1.0
name: L-tryptophan

metaR CAATPS
is: SBO:0000185
name: Ca ATPase
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.3.8
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000269
product: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
reversible: false
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ

metaM udpacgal l
has only substance units: false
constant: false
boundary condition: false
type: Species
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57847
name: UDP-N-acetyl-D-galactosamine(2-)
is: SBO:0000247
is: HMDB00304

metaM for r
is: CHEBI:15740
initial concentration: 1.0
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
constant: false
name: Formate
boundary condition: false
is: SBO:0000247
is: C00058
initial amount: NaN
is: HMDB00142
has only substance units: false
type: Species

metaR H2Otg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110007#
is described by: ECO:0000000
name: H2O transport, Golgi apparatus
type: Reaction

metaR FRDPtc
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110007#
is described by: ECO:0000000
fast: false
product: MODEL1310110007#
name: lipid, flip-flop intracellular transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_4aa44d82_74cc_4e85_80e8_f02ce76e0c2f
has only substance units: false
initial amount: NaN
boundary condition: true
name: HAS2
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q92819
is encoded by: hsa:3037
constant: false

metaM lnlnca e
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:32387
name: alpha-linolenate
initial amount: NaN
has only substance units: false
is: HMDB01388
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_fff68834_eff0_4658_9c61_04e08a841af4
boundary condition: true
is encoded by: hsa:4830
name: NME1:NME2
has part: P22392
initial amount: NaN
is: SBO:0000297
has part: P15531
initial concentration: NaN
is encoded by: hsa:4831
has only substance units: false
type: Species
constant: false

metaM HC02179 e
constant: false
initial amount: NaN
type: Species
name: 20-hydroxy-arachidonate
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:34306
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
boundary condition: false

metaR r0779
fast: false
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
kinetic law: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110007#
product: MODEL1310110007#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110007#_30de91ec_e98f_48da_a627_2df778a834cf
is: SBO:0000252
is encoded by: hsa:3242
initial amount: NaN
name: HPD
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: B3KQ63
type: Species

metaR KSII CORE2tly
product: MODEL1310110007#
type: Reaction
name: keratan sulfate II (core 2) transport, extracellular to lysosome
kinetic law: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110007#_e99b6b37_883d_4e0d_9799_aac65b8aaed1
is: P51828
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
name: ADCY7
is encoded by: hsa:113
initial concentration: NaN

metaM tyr L e
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: CHEBI:17895
is: HMDB00158
name: L-tyrosine
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
type: Species

metaR FAOXC122C101m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_a06e7c15_554c_4443_9584_0f0e1f3dcdae
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: MAN1A2
initial concentration: NaN
is encoded by: hsa:10905
boundary condition: true
is: O60476
constant: false
type: Species

metaR r2308
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_0fa7fbaa_5df4_413f_873f_1d181b5fa933
initial amount: NaN
is: SBO:0000252
type: Species
is: Q9H3H5
constant: false
initial concentration: NaN
name: DPAGT1
has only substance units: false
boundary condition: true
is encoded by: hsa:1798

metaR RE1522M
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1522
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
reactant: MODEL1310110007#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110007#
kinetic law: MODEL1310110007#

metaR RE2675C
fast: false
type: Reaction
product: MODEL1310110007#
is: SBO:0000176
reactant: MODEL1310110007#
name: RE2675
reversible: false
notes: GENE_ASSOCIATION: (8560.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10722759,PMID:10880336,PMID:11937514,PMID:8449895 NOTES:
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000

metaR NAIt
fast: false
kinetic law: MODEL1310110007#
reversible: true
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
name: Na+ / iodide cotransport
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD

metaR r2079
reversible: true
fast: false
reactant: MODEL1310110007#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110007#
product: MODEL1310110007#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_874e2675_b36b_4630_bbc0_283442b0e437
name: NOS1
is encoded by: hsa:4842
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: B4DG68
boundary condition: true

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_bc65f6a8_dc74_444c_a689_b50b46e751a2
has part: P27986
constant: false
has only substance units: false
is: SBO:0000297
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
name: PIK3CA:PIK3R1
is encoded by: hsa:5295

metaM hs deg18 l
has only substance units: false
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
is: HMDB01352
type: Species
is: SBO:0000247
initial concentration: 1.0
name: heparan sulfate, degradation product 18
boundary condition: false
is: CHEBI:17180
constant: false
initial amount: NaN

metaR r2394
product: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110007#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_34d5ae76_0722_40a7_aab4_0570ad055c45
has only substance units: false
name: _D87002_1_m
is encoded by: hsa:D87002
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_93bea5ff_582b_48eb_a86b_21f1b72297d2
has only substance units: false
constant: false
is: P11908
is: SBO:0000252
type: Species
is encoded by: hsa:5634
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: PRPS2

metaR r1594
fast: false
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true

metaR DM fol
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

metaR FAOXC226205m
modifier: MODEL1310110007#
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110007#
reversible: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
reactant: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#

metaM C04849 e
is: SBO:0000247
boundary condition: false
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57449
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
initial amount: NaN

metaR O2ter
kinetic law: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
name: O2 transport, endoplasmic reticulum
reversible: true

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaR GLYCTDle
fast: false
kinetic law: MODEL1310110007#
is described by: ECO:0000134
reversible: true
is: SBO:0000185
name: difussion of glycerol accross the brush border membrane
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110007#
product: MODEL1310110007#

metaR RE3003M
is described by: ECO:0000000
name: RE3003
reactant: MODEL1310110007#
modifier: MODEL1310110007#
product: MODEL1310110007#
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110007#_d6bb50f5_948d_40cf_9697_86505f9b4618
is: Q674R7
name: ATG9B
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:285973
constant: false
is: SBO:0000252

metaM mpdol L c
initial concentration: 1.0
notes: FORMULA: C1300H2128N20O220P20 CHARGE: -20 INCHI: InChI=1S/C47H82N2O22P2/c1-26(2)13-9-14-27(3)15-10-16-28(4)17-11-18-29(5)19-12-20-30(6)21-22-64-72(60,61)71-73(62,63)70-46-37(49-32(8)54)40(57)43(35(25-52)67-46)68-45-36(48-31(7)53)39(56)44(34(24-51)66-45)69-47-42(59)41(58)38(55)33(23-50)65-47/h13,15,17,19,30,33-47,50-52,55-59H,9-12,14,16,18,20-25H2,1-8H3,(H,48,53)(H,49,54)(H,60,61)(H,62,63)/b27-15+,28-17+,29-19+/t30?,33-,34-,35-,36-,37-,38-,39-,40-,41+,42+,43-,44-,45+,46-,47+/m1/s1
boundary condition: false
is: CHEBI:18396
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species

metaM fad c
is: HMDB01248
is: C00016
is: SBO:0000247
name: Flavin adenine dinucleotide oxidized
has only substance units: false
is: CHEBI:16238
boundary condition: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false

metaR TXASr
is described by: ECO:0000134
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/5.3.99.5
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
name: Thromboxane-A synthase
type: Reaction
fast: false
reactant: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#
reversible: false
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_1f310a24_a4bc_4740_a86c_efab3b497422
boundary condition: true
is encoded by: hsa:956
is: O75355
has only substance units: false
type: Species
initial concentration: NaN
name: ENTPD3
constant: false
is: SBO:0000252
initial amount: NaN

metaM retinol cis 11 c
constant: false
initial concentration: 1.0
is: CHEBI:16302
name: 11-cis-retinol
has only substance units: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB06216

http://identifiers.org/biomodels.db/MODEL1310110007#_e9182341_4838_4289_af7d_320146dead60
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2639
type: Species
is: Q92947
initial amount: NaN
is: SBO:0000252
name: GCDH

metaM taur c
name: Taurine
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00251
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C2H7NO3S CHARGE: 0
is: C00245
is: CHEBI:3544
is: SBO:0000247

metaR r0139
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#
is described by: ECO:0000000
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.2.2
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
modifier: MODEL1310110007#

metaR DESAT22 2p
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
reversible: false
is: SBO:0000176
reactant: MODEL1310110007#

metaM HC00591 c
is: CHEBI:16769
name: 2-oxoglutaramate
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

metaR r1595
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false
type: Reaction
product: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX sprm LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_sprm(e)
type: Reaction

metaM gal l
has only substance units: false
is: SBO:0000247
is: CHEBI:12936
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
name: D-galactose
is: HMDB00143
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124

metaR P5CRm
fast: false
name: pyrroline-5-carboxylate reductase (m)
is: SBO:0000176
is described by: ECO:0000304
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reversible: false
type: Reaction
product: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.5.1.2
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:

metaR LPCOXp
type: Reaction
modifier: MODEL1310110007#
name: L-pipecolate oxidase, peroxisomal
kinetic law: MODEL1310110007#
is: SBO:0000176
reversible: false
fast: false
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
is version of: http://identifiers.org/ec-code/1.5.3.1
reactant: MODEL1310110007#
is described by: ECO:0000269
product: MODEL1310110007#

metaR r1670
modifier: MODEL1310110007#
is: SBO:0000185
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
product: MODEL1310110007#
is described by: ECO:0000000
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true

metaM gtp m
is: C00044
is: SBO:0000247
constant: false
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:37565
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
name: GTP
is: HMDB01273

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

metaR RBFK
is version of: http://identifiers.org/ec-code/2.7.1.26
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
reversible: false
fast: false
product: MODEL1310110007#
name: riboflavin kinase
modifier: MODEL1310110007#
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#

metaR r0027
reversible: true
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.39
modifier: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000176
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_b81969a5_0dff_49a7_b550_e33a007ccdaf
name: _AI684467_1_m
initial amount: NaN
is encoded by: hsa:AI684467
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
type: Species
has only substance units: false

metaR r1596
reactant: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false

metaR G6PDH1rer
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
type: Reaction
modifier: MODEL1310110007#
fast: false
product: MODEL1310110007#
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
reversible: true
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.47
is: SBO:0000176
is described by: ECO:0000269

metaR HAS2
name: hyaluronan synthase
fast: false
type: Reaction
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110007#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.212
reactant: MODEL1310110007#
reversible: false
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_56a98a7d_d66e_4e6e_a97e_0c9bd22476fc
initial concentration: NaN
has only substance units: false
name: ADHFE1
initial amount: NaN
boundary condition: true
is: Q8IWW8
constant: false
is: SBO:0000252
is encoded by: hsa:137872
type: Species

metaM thmpp m
constant: false
name: Thiamine diphosphate
has only substance units: false
initial concentration: 1.0
is: HMDB01372
boundary condition: false
type: Species
is: CHEBI:45931
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 INCHI: InChI=1S/C12H18N4O7P2S/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21) HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_afdd028a_b809_41a2_a250_74c012d36daa
is: B2ZGL7
constant: false
name: MGLL
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:11343

metaM ksi deg16 l
notes: FORMULA: C160H258N11O137S7 CHARGE: -7
has only substance units: false
type: Species
is: HMDB00812
is: SBO:0000247
is: CHEBI:16953
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 16

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_67a2c703_c1dc_44fc_bd6f_ecf32175c3f0
name: SLC29A1
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:2030
is: Q99808
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false

metaM lnlnca r
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
name: alpha-linolenate
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:32387
is: HMDB01388
constant: false

metaR r0425
is version of: http://identifiers.org/ec-code/1.17.1.4
product: MODEL1310110007#
name: EC:1.1.1.42
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: true
reactant: MODEL1310110007#

metaR FAOXC102m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

metaM amet c
is: HMDB01185
name: S-Adenosyl-L-methionine
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
constant: false
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:15414
is: SBO:0000247
initial concentration: 1.0
is: C00019

metaR ALAt2r
type: Reaction
is: SBO:0000185
is described by: ECO:0000304
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reversible: true
name: L-alanine reversible transport via proton symport
reactant: MODEL1310110007#
fast: false

metaM cholcoa c
is: HMDB01374
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
boundary condition: false
name: choloyl-CoA(4-)
initial amount: NaN
type: Species
is: CHEBI:57373
initial concentration: 1.0

metaR CHOLATEt
is: SBO:0000185
reversible: true
product: MODEL1310110007#
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
type: Reaction
fast: false
name: cholate transport via bicarbonate countertransport

metaR CITRtm
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
product: MODEL1310110007#
modifier: MODEL1310110007#
is: SBO:0000185
reversible: true
name: citrulline mitochondrial transport via proton antiport
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110007#

metaM gtp n
name: GTP(4-)
initial amount: NaN
is: HMDB01273
boundary condition: false
is: CHEBI:37565
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
has only substance units: false

metaM crm hs r
initial amount: NaN
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
type: Species
name: N-acylsphingosine
is: SBO:0000247
is: CHEBI:52639
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0

metaR r1597
reactant: MODEL1310110007#
fast: false
product: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110007#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110007#_0fc20507_26ac_4d7b_81d6_3f1fa2e0364d
name: PTGIS
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: Q16647
is encoded by: hsa:5740
initial amount: NaN
constant: false

metaR r0413
product: MODEL1310110007#
is: SBO:0000176
name: dATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
reactant: MODEL1310110007#
reversible: false
fast: false
kinetic law: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
modifier: MODEL1310110007#

metaR DHCHOLESTANATEtm
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110007#
product: MODEL1310110007#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_8a981871_f534_4910_8ced_0e2bae3d2862
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
name: PEMT
is encoded by: hsa:10400

metaR r0365
type: Reaction
product: MODEL1310110007#
reactant: MODEL1310110007#
reversible: false
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.72
fast: false
modifier: MODEL1310110007#
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
is: SBO:0000176
kinetic law: MODEL1310110007#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_44979b45_f08d_4bce_9271_b229c3be0a8c
initial amount: NaN
constant: false
boundary condition: true
is: P78382
is: SBO:0000252
has only substance units: false
name: SLC35A1
initial concentration: NaN
is encoded by: hsa:10559
type: Species

metaM gluala e
is: http://identifiers.org/pubchem.compound/6503
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
is: SBO:0000247
has only substance units: false
name: 5-L-Glutamyl-L-alanine
boundary condition: false
is: C03740
type: Species
is: HMDB06248

metaR r0426
reactant: MODEL1310110007#
reversible: true
modifier: MODEL1310110007#
fast: false
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
product: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.5.1.34
is: SBO:0000176
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110007#_f2f03c79_eea5_4c76_9668_abee61f3a35c
is encoded by: hsa:2686
is: A0PJJ9
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
name: GGT7
constant: false

metaM 5HPET c
constant: false
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
name: 5(S)-HPETE(1-)
is: HMDB01193
is: CHEBI:57450
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_ca8bacb3_9c8b_44f8_b177_f09e5ede2dee
is encoded by: hsa:8803
is: SBO:0000252
boundary condition: true
name: SUCLA2
initial concentration: NaN
is: E5KS60
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaR r0021
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
is described by: ECO:0000000
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110007#
reversible: true
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
type: Reaction
modifier: MODEL1310110007#
product: MODEL1310110007#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_5cc4bde1_8958_4e60_afcf_cf59d6d292cb
is: SBO:0000252
initial concentration: NaN
is: Q5QPH3
name: ACSS2
constant: false
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:55902
boundary condition: true

metaR r1598
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110007#
fast: false
type: Reaction
kinetic law: MODEL1310110007#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110007#

metaR VLCS2p
name: Very-long-chain-fatty-acid-CoA ligase
reactant: MODEL1310110007#
is: SBO:0000176
product: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: PMID:10479480 NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is described by: ECO:0000304
fast: false
modifier: MODEL1310110007#
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR URIt
is described by: ECO:0000269
type: Reaction
reversible: true
reactant: MODEL1310110007#
name: uridine facilated transport in cytosol
modifier: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
product: MODEL1310110007#
fast: false

metaR PHACCOAGLNAC
is: SBO:0000176
product: MODEL1310110007#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
reversible: false

metaR Htg
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
product: MODEL1310110007#
reversible: true
name: proton diffusion (Golgi)
is: SBO:0000185
is described by: ECO:0000000

metaR H2Otm
name: H2O transport, mitochondrial
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
fast: false
kinetic law: MODEL1310110007#
reversible: true
modifier: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_07574352_bba9_4d6c_846c_cb08bac6dc3a
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: true
name: NME7
is encoded by: hsa:29922

http://identifiers.org/biomodels.db/MODEL1310110007#_e1b24430_4854_444b_bd3c_6ab885206686
initial amount: NaN
is: O95479
constant: false
is encoded by: hsa:9563
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
name: H6PD
has only substance units: false

metaM dcmp n
initial concentration: 1.0
constant: false
is: CHEBI:57566
type: Species
is: HMDB01202
name: dCMP(2-)
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR ARACHDtr
fast: false
is: SBO:0000185
kinetic law: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
name: intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
reactant: MODEL1310110007#
product: MODEL1310110007#

metaM dgtp e
constant: false
name: dGTP
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: CHEBI:16497
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB01440

metaR NACHEXA21ly
reactant: MODEL1310110007#
is: SBO:0000176
product: MODEL1310110007#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
fast: false
name: beta-N-acetylhexosaminidase A, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#

metaM glu5sa m
constant: false
initial concentration: 1.0
name: L-Glutamate 5-semialdehyde
is: HMDB02104
type: Species
is: C01165
is: CHEBI:17232
has only substance units: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR EX CE1936 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermine dialdehyde exchange
type: Reaction

metaR r0642
reversible: true
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
kinetic law: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000000

metaR ANDRSTRNte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fast: false
name: androsterone transport
product: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_21cce74a_97c3_4aee_bc66_49bdbfcd4423
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:6569
has only substance units: false
type: Species
name: SLC34A1
is: SBO:0000252
is: Q7Z725
boundary condition: true

metaR P45027A11m
is described by: ECO:0000269
fast: false
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
modifier: MODEL1310110007#
reversible: false
is: SBO:0000176
reactant: MODEL1310110007#
product: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110007#

metaM 5mdr1p c
name: 5-Methylthio-5-deoxy-D-ribose 1-phosphate
is: HMDB00963
initial amount: NaN
has only substance units: false
constant: false
is: C04188
notes: FORMULA: C6H11O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02120 EHMN_ABBREVIATION: C04188
is: SBO:0000247
is: CHEBI:58533
initial concentration: 1.0
type: Species
boundary condition: false

metaR r0022
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110007#
fast: false
modifier: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.8.1.7

metaR GALASE6ly
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
type: Reaction

metaR r1599
reactant: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
is described by: ECO:0000000
reversible: true

metaM ksi deg35 l
is: SBO:0000247
constant: false
name: keratan sulfate I, degradation product 35
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00143
initial concentration: 1.0
is: CHEBI:12936
boundary condition: false

metaR KYNATESYN
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
product: MODEL1310110007#
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110007#_8487e0f8_92f1_4cee_a279_d971efef55d1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3422
name: IDI1
initial amount: NaN
constant: false
has only substance units: false
is: Q13907
initial concentration: NaN
type: Species

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaR RE1517M
reactant: MODEL1310110007#
modifier: MODEL1310110007#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.13
type: Reaction
product: MODEL1310110007#
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
name: RE1517

metaR RE2973C
name: RE2973
product: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.1.137
kinetic law: MODEL1310110007#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.1.154
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: true
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

metaM prostgf2 c
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:57404
initial amount: NaN
is: HMDB01139
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
name: prostaglandin F2alpha(1-)
type: Species
initial concentration: 1.0

metaR EX glysar LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylsarcosine
type: Reaction

metaR MALSO4tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
modifier: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
name: Malate:sulfate antiport, mitochondrial
product: MODEL1310110007#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110007#
reversible: true

metaR r0295
is described by: ECO:0000000
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
type: Reaction
product: MODEL1310110007#
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
reversible: false
is: SBO:0000176
fast: false

metaR H2Otn
fast: false
product: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: H2O transport, nuclear

metaR PDE1
type: Reaction
reactant: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.4.35
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.4.17
is: SBO:0000176
kinetic law: MODEL1310110007#
fast: false
name: 3',5'-cyclic-nucleotide phosphodiesterase

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaM acn13acngalgbside hs c
is: SBO:0000247
is: C00036
name: sialyl (1,3) sialyl (2,6) galactosylgloboside
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: HMDB00223
is: CHEBI:3338
initial amount: NaN
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110007#_fc0cbfad_a258_4493_9295_51dfa966d7e7
name: NDUFA4L2
boundary condition: true
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:56901
has only substance units: false
is: SBO:0000252
is: Q9NRX3

http://identifiers.org/biomodels.db/MODEL1310110007#_16393092_25fa_402f_b361_4b1c635752a2
boundary condition: true
type: Species
is: SBO:0000252
name: DLAT
has only substance units: false
is: Q86YI5
initial amount: NaN
is encoded by: hsa:1737
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_dc2096c0_0f21_432c_99f0_c59554672885
is: SBO:0000252
has only substance units: false
name: NT5E
is: P21589
is encoded by: hsa:4907
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
boundary condition: true

metaR r0641
is: SBO:0000176
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
kinetic law: MODEL1310110007#
fast: false
product: MODEL1310110007#
type: Reaction
reversible: true
reactant: MODEL1310110007#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.4
modifier: MODEL1310110007#
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2

metaM h2o2 x
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
name: Hydrogen peroxide
is: HMDB03125
is: CHEBI:16240
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: C00027

metaM ksi deg4 l
is: SBO:0000247
name: keratan sulfate I, degradation product 4
initial amount: NaN
is: HMDB00868
constant: false
type: Species
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57737

http://identifiers.org/biomodels.db/MODEL1310110007#_e3ac6993_41d2_440d_b41e_750242427f4b
is encoded by: hsa:8802
has part: Q96I99
type: Species
boundary condition: true
has part: P53597
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8801
initial amount: NaN
name: SUCLG2:SUCLG1
constant: false
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110007#_bf5066ea_4f22_49ed_b67b_de130aca3097
is: P26439
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:3284
name: HSD3B2

http://identifiers.org/biomodels.db/MODEL1310110007#_882de368_7bbe_4f01_aa69_d21929243f02
is: P60891
has only substance units: false
name: PRPS1
boundary condition: true
is encoded by: hsa:5631
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_bb9a457c_ac5c_4d14_8378_574feb2bbc10
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
name: LDHA
has only substance units: false
is encoded by: hsa:3939
boundary condition: true
is: P00338
is: SBO:0000252

metaM pect e
notes: FORMULA: C2535H3509O2535 CHARGE: -1
constant: false
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: HMDB03402
is: SBO:0000247
initial concentration: 1.0
name: pectins

metaR NDPK7n
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
kinetic law: MODEL1310110007#
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110007#
type: Reaction
reversible: true
fast: false
product: MODEL1310110007#
is described by: ECO:0000304
is: SBO:0000176

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaR r1671
modifier: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
reversible: true
fast: false
name: Y+LAT2 Utilized transport

metaR HSD3A2r
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
reversible: true
type: Reaction
modifier: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.225
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
kinetic law: MODEL1310110007#
product: MODEL1310110007#
fast: false
is: SBO:0000176

metaM fad e
is: HMDB01248
is: CHEBI:16238
name: Flavin adenine dinucleotide oxidized
is: SBO:0000247
is: C00016
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false

metaR VLCS2r
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
fast: false
modifier: MODEL1310110007#
reversible: false
name: Very-long-chain-fatty-acid-CoA ligase
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110007#
type: Reaction
is described by: ECO:0000304
is: SBO:0000176

metaM gal e
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00143
boundary condition: false
is: SBO:0000247
is: C00124
is: CHEBI:0
name: D-Galactose
type: Species
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0

metaR r0360
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is version of: http://identifiers.org/ec-code/6.2.1.16
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
reversible: false
product: MODEL1310110007#
modifier: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000000

metaR BACCL
name: biotin-[acetyl-CoA-carboxylase] ligase
type: Reaction
fast: false
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/6.3.4.10
is: SBO:0000176
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
reversible: false
kinetic law: MODEL1310110007#
is described by: ECO:0000269
reactant: MODEL1310110007#

metaR 5ADTSTSTERONESte
reactant: MODEL1310110007#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110007#
product: MODEL1310110007#
fast: false
name: sulfonated testosterone transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_5d64d9b9_3075_47cf_acda_d88aebcb1ea4
is: Q10472
is: SBO:0000252
is encoded by: hsa:2589
name: GALNT1
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false

metaM 4ppan c
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
is: SBO:0000247
is: CHEBI:10986
type: Species
constant: false
initial amount: NaN
name: D-4'-Phosphopantothenate
has only substance units: false
is: HMDB01016
is: C03492
boundary condition: false
initial concentration: 1.0

metaR RE1810M
reactant: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
is: SBO:0000176
name: RE1810
kinetic law: MODEL1310110007#
fast: false
reversible: true
product: MODEL1310110007#

metaM dgtp c
is: CHEBI:16497
name: dGTP
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB01440
is: C00286
constant: false
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286

http://identifiers.org/biomodels.db/MODEL1310110007#_099bf08b_66a1_4257_b9fa_4f5681ceb3eb
boundary condition: true
is: P49448
has only substance units: false
name: GLUD2
type: Species
is encoded by: hsa:2747
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN

metaR RE3624M
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reversible: false
reactant: MODEL1310110007#
name: RE3624
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
kinetic law: MODEL1310110007#
product: MODEL1310110007#
fast: false
modifier: MODEL1310110007#
is: SBO:0000176

metaR CYSTS
is described by: ECO:0000269
product: MODEL1310110007#
type: Reaction
modifier: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (875.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.2.1.22 Confidence Level: 4 AUTHORS: PMID:681363,PMID:9790750 NOTES:NCD
name: cystathionine beta-synthase
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.2.1.22
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110007#_58a2d316_0f8d_4cad_8e84_7f1ac49ce827
boundary condition: true
is: Q96FL9
initial amount: NaN
constant: false
name: GALNT14
is: SBO:0000252
is encoded by: hsa:79623
type: Species
initial concentration: NaN
has only substance units: false

metaR TCYNTtm
reversible: false
kinetic law: MODEL1310110007#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
product: MODEL1310110007#
name: Thiocyanate transport via diffusion (mitochondrial)
reactant: MODEL1310110007#

metaM udpacgal c
initial amount: NaN
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial concentration: 1.0
is: CHEBI:57847
boundary condition: false
constant: false
has only substance units: false
name: UDP-N-acetyl-D-galactosamine(2-)
is: HMDB00304
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_2c4625c1_9a4e_4fa0_912c_13cfa36d58c8
name: GGT2
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:728441
boundary condition: true

metaM r1p c
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
initial amount: NaN
is: HMDB01489
name: alpha-D-Ribose 1-phosphate
is: CHEBI:57720
type: Species
is: C00442

metaM cdpchol c
name: CDPcholine
is: CHEBI:16436
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB01413
notes: FORMULA: C14H25N4O11P2 CHARGE: -1 INCHI: InChI=1S/C14H26N4O11P2/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25)/t9-,11-,12-,13-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00263 EHMN_ABBREVIATION: C00307
type: Species
constant: false
initial amount: NaN

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_82627f91_4795_4ee9_9981_dc0627d1d216
is: Q92959
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:6578
has only substance units: false
is: SBO:0000252
type: Species
name: SLCO2A1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_70387114_96d2_4c15_8428_bb34c11b7ee0
is encoded by: hsa:5728
has only substance units: false
name: PTEN
boundary condition: true
is: F6KD01
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM lnlnca l
is: CHEBI:32387
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
initial amount: NaN
name: alpha-linolenate
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01388
type: Species
boundary condition: false

metaM glcur c
has only substance units: false
is: SBO:0000247
name: D-glucuronate
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: HMDB00127
constant: false
is: CHEBI:15748
initial concentration: 1.0

metaM prostgf2 e
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:57404
is: HMDB01139
type: Species
name: prostaglandin F2alpha(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM taur e
type: Species
is: SBO:0000247
name: Taurine
constant: false
initial amount: NaN
is: HMDB00251
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: C00245
notes: FORMULA: C2H7NO3S CHARGE: 0
is: CHEBI:3544

http://identifiers.org/biomodels.db/MODEL1310110007#_8e0900ea_2e8f_4822_9bb4_d9e897654d28
is encoded by: hsa:4513
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
is: Q7GXZ8
name: COX2

metaR TCYNTt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
reversible: false
is: SBO:0000185
product: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
name: Thiocyanate transport via diffusion (cytosol to extracellular)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_1ff87fa1_fd9e_4eb2_aa24_c2e758d69156
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
is: Q14432
boundary condition: true
name: PDE3A
initial concentration: NaN
is encoded by: hsa:5139
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_947e881a_3020_4f7d_9b00_2fc59c8456d9
name: SLC23A1
initial amount: NaN
is: Q9UHI7
is encoded by: hsa:9963
boundary condition: true
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR GLCAASE9ly
is: SBO:0000176
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
kinetic law: MODEL1310110007#
fast: false
type: Reaction
reactant: MODEL1310110007#
modifier: MODEL1310110007#
name: beta-glucuronidase, lysosomal
product: MODEL1310110007#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: false

metaR r1672
modifier: MODEL1310110007#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000185

metaR H2Otp
is described by: ECO:0000000
reactant: MODEL1310110007#
type: Reaction
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: H2O transport, peroxisomal

metaM acn13acngalgbside hs e
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: CHEBI:3338
boundary condition: false
is: SBO:0000247
name: sialyl (1,3) sialyl (2,6) galactosylgloboside
initial concentration: 1.0
initial amount: NaN
is: C00036
type: Species
constant: false
has only substance units: false
is: HMDB00223

http://identifiers.org/biomodels.db/MODEL1310110007#_73288617_3c6b_4eac_855b_3fe9f1959a30
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:1351
name: COX8A
is: Q53XN1
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM maltpt e
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5141
is: HMDB01296
name: maltopentaose
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
is: C02052

metaR DMATTx
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
fast: false
reversible: false
modifier: MODEL1310110007#
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.5.1.1
is: SBO:0000176
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000134
name: dimethylallyltranstransferase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_16bc46a3_a5d0_48a6_bea1_3e0337844a13
type: Species
constant: false
initial concentration: NaN
name: OGDH
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4967
boundary condition: true
is: Q02218
initial amount: NaN

metaR r1944
fast: false
reversible: false
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110007#
product: MODEL1310110007#
name: Y+LAT2 Utilized transport
type: Reaction

metaR r0633
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.3
reactant: MODEL1310110007#
reversible: true
product: MODEL1310110007#
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is described by: ECO:0000000
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false

metaM CE5236 n
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28002
has only substance units: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
boundary condition: false
name: O2'-4a-cyclic-tetrahydrobiopterin
is: HMDB03952

metaM glutcoa m
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
is: SBO:0000247
type: Species
is: CHEBI:57378
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
name: glutaryl-CoA(5-)
is: HMDB01339
boundary condition: false

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaR GLCNACPT L
reactant: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.8.15
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110007#
fast: false
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (liver)
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110007#_93d5002d_9380_4430_ac33_044c707604f0
boundary condition: true
has only substance units: false
type: Species
name: SLC6A5
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is: Q9Y345
is encoded by: hsa:9152

metaM bilirub c
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57977
initial amount: NaN
boundary condition: false
name: bilirubin(2-)
is: HMDB00054
type: Species
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
has only substance units: false

metaM HC02216 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
constant: false
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: prostaglandin-f2beta
is: CHEBI:28922
is: SBO:0000247

metaR PGDI
reversible: true
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.5.1.18
fast: false
is: SBO:0000176
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/5.3.99.2
product: MODEL1310110007#
reactant: MODEL1310110007#
name: Prostaglandin-H2 D-isomerase [Precursor]
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
is described by: ECO:0000269
type: Reaction

metaR FAOXC164GC163m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

metaR r1377
kinetic law: MODEL1310110007#
reversible: true
reactant: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_d4c7b371_f231_4334_a792_1ba68743f8c7
constant: false
has only substance units: false
is: SBO:0000252
is: O15244
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:6582
boundary condition: true
name: SLC22A2

http://identifiers.org/biomodels.db/MODEL1310110007#_68191e16_e4d1_418a_8b99_079e1dfe6111
is: F5H6D0
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:7841
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
name: MOGS

http://identifiers.org/biomodels.db/MODEL1310110007#_82cc1a8b_9ab8_4e24_923b_a2d55ec0b2c5
initial amount: NaN
is encoded by: hsa:AA502753
constant: false
has only substance units: false
is: SBO:0000252
name: _AA502753_1_m
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_3c5f6902_2e1e_4004_b4e0_4e04267bbf1b
is encoded by: hsa:229
name: ALDOB
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: P05062

http://identifiers.org/biomodels.db/MODEL1310110007#_de94971c_d2fe_44bf_881a_59df94b972a0
boundary condition: true
initial amount: NaN
type: Species
name: SLCO4A1
is: Q96BD0
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:28231
is: SBO:0000252

metaM thmpp c
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
name: Thiamine diphosphate
is: C00068
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB01372
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:45931

metaR ACACT1x
product: MODEL1310110007#
reactant: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000134
name: acetyl-CoA C-acetyltransferase, mitochondrial
kinetic law: MODEL1310110007#
type: Reaction
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
is version of: http://identifiers.org/ec-code/2.3.1.9
fast: false

metaR r0634
reversible: true
fast: false
product: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
modifier: MODEL1310110007#
is: SBO:0000176
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.4.1
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110007#_7f05c1fe_eb83_4b44_a174_1cb4a9c377dd
constant: false
initial amount: NaN
type: Species
is: A8K0I1
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:160851
name: DGKH

metaM gln L e
constant: false
is: SBO:0000247
name: L-glutamine
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00641
type: Species
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: CHEBI:18050

http://identifiers.org/biomodels.db/MODEL1310110007#_152d14cd_28da_4500_8b7b_111f432a5db0
name: B3GNT3
has only substance units: false
is encoded by: hsa:10331
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: Q9Y2A9

metaM acetone m
constant: false
is: HMDB01659
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
boundary condition: false
name: acetone
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:15347
is: SBO:0000247

metaM acnam l
name: N-acetylneuraminate
initial amount: NaN
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
boundary condition: false
is: CHEBI:35418
is: SBO:0000247
type: Species
is: HMDB00230
initial concentration: 1.0
has only substance units: false
constant: false

metaR CITtam
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110007#
fast: false
type: Reaction
modifier: MODEL1310110007#
product: MODEL1310110007#
reversible: true
name: citrate transport, mitochondrial

metaR r0584
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
kinetic law: MODEL1310110007#
is: SBO:0000176
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
type: Reaction
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
reversible: true
modifier: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000000

metaR ADSK
type: Reaction
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
fast: false
is: SBO:0000176
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
name: adenylyl-sulfate kinase
reactant: MODEL1310110007#
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.25

metaM 2mop m
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB01172
name: 2-methyl-3-oxopropanoate
initial amount: NaN
constant: false
is: CHEBI:57700
has only substance units: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial concentration: 1.0

metaR DNDPt14m
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
modifier: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false
name: dUDP transport via dTDP antiport
reactant: MODEL1310110007#
is: SBO:0000185

metaR FRDPtcr
is: SBO:0000185
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
fast: false
reversible: true
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
product: MODEL1310110007#

metaR CSNt
reversible: true
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
type: Reaction
reactant: MODEL1310110007#
name: cytosine transport via facilated diffusion
fast: false

metaM sphmyln hs c
is: SBO:0000247
constant: false
name: sphingomyelin betaine
boundary condition: false
has only substance units: false
is: CHEBI:58216
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
initial concentration: 1.0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_6e986485_c27f_4cf9_90ea_d53e7aa1fc13
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: PDE8A
has only substance units: false
type: Species
boundary condition: true
is: O60658
is encoded by: hsa:5151

http://identifiers.org/biomodels.db/MODEL1310110007#_60cffb2c_f3cb_4930_a85c_63204cf2cc22
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: ALG3
is encoded by: hsa:10195
boundary condition: true
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_5ea41a51_46fe_4f39_8eda_c5647e5319bd
is encoded by: hsa:18
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
name: ABAT
constant: false

metaM dhcholestancoa r
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB02159
is: CHEBI:15494
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM hs deg9 l
is: CHEBI:18268
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
name: heparan sulfate, degradation product 9
initial amount: NaN
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB06355
is: SBO:0000247

metaM h2o2 m
boundary condition: false
is: C00027
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB03125
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
name: Hydrogen peroxide

http://identifiers.org/biomodels.db/MODEL1310110007#_b8535d60_4d57_442c_ae30_34b1cb3d2c31
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:AI697028
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
name: _AI697028_1_e

metaR r1942
fast: false
type: Reaction
modifier: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110007#
product: MODEL1310110007#
name: Y+LAT2 Utilized transport
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110007#_4d4556c1_6117_45c4_a013_43b01193663b
constant: false
is: Q4F7X0
has only substance units: false
initial amount: NaN
is encoded by: hsa:114
initial concentration: NaN
name: ADCY8
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_ec0522ae_98e2_46b5_8748_1909d9312179
is encoded by: hsa:27306
name: HPGDS
constant: false
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: O60760

metaR r0845
reversible: false
name: Drug/Metabolite Transporter (DMT) TCDB:2.A.7.12.7
product: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12759756,PMID:17466261,PMID:9759482 NOTES:UGLCNACtg but different compartment
type: Reaction

metaM bilirub e
is: HMDB00054
type: Species
constant: false
name: bilirubin(2-)
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: CHEBI:57977

metaR GGH 10FTHF6GLUe
reactant: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
fast: false
product: MODEL1310110007#
reversible: false
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular

metaR NS26Tg
reactant: MODEL1310110007#
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (55808.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.3 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.99.3
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_5e52d82f_0e88_478c_a457_09cf22a9097c
is encoded by: hsa:5295
boundary condition: true
is: SBO:0000297
initial concentration: NaN
has part: E7EX19
constant: false
type: Species
name: PIK3CD:PIK3R1
initial amount: NaN
has only substance units: false

metaM HC02216 e
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:28922
has only substance units: false
initial concentration: 1.0
name: prostaglandin-f2beta

metaR FAOXC200180m
product: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110007#
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110007#
is described by: ECO:0000000
fast: false
reversible: false
reactant: MODEL1310110007#

metaR S6TASE12ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110007#
reversible: true

metaR r0208
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.4.1.1
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
product: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110007#
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
fast: false
reversible: true
is: SBO:0000176

metaR HDCAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
fast: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110007#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_7d5901b8_05f1_4795_8d26_309b06b92b9d
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: FTCD
is encoded by: hsa:10841
is: SBO:0000252
is: O95954
boundary condition: true

metaR RE0512M
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
name: RE0512

metaM 6dhf m
is: SBO:0000247
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
name: hexaglutamyl folate (DHF)
boundary condition: false
has only substance units: false
is: HMDB06563

metaM h2o2 l
is: HMDB03125
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: hydrogen peroxide
type: Species
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: CHEBI:16240
initial concentration: 1.0

metaM btcoa m
is: HMDB01088
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57371
has only substance units: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
is: C00136
type: Species
boundary condition: false
name: Butanoyl-CoA
constant: false

metaR SCP21cx
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of phytanoylcoa from cytosol to peroxisomes.
type: Reaction

metaR ENGASE3ly
reactant: MODEL1310110007#
name: endo-beta-N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
type: Reaction
product: MODEL1310110007#
reversible: false
fast: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110007#_1bc6dd20_fc72_4cea_bfa7_5545b57ca1f7
constant: false
initial amount: NaN
is encoded by: hsa:AF116616
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: _AF116616_1_m
boundary condition: true

metaM ksi deg13 l
has only substance units: false
name: keratan sulfate I, degradation product 13
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:16953
boundary condition: false
notes: FORMULA: C174H280N12O150S8 CHARGE: -8
is: SBO:0000247
is: HMDB00812

http://identifiers.org/biomodels.db/MODEL1310110007#_993da91a_297e_4fcd_bad6_128385f389bd
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: Q549M5
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4718
boundary condition: true
name: NDUFC2

metaR r1378
reactant: MODEL1310110007#
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
is: SBO:0000176
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
reversible: true
kinetic law: MODEL1310110007#
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_e36511d0_0416_4635_bd9e_2046cdf584d2
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: B3KT70
type: Species
initial concentration: NaN
is encoded by: hsa:80201
name: HKDC1
has only substance units: false

metaR M4MPDOL Lter
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
name: m4mpdol flippase
fast: false
is described by: ECO:0000000

metaR METATB0tc
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Methionine into the intestinal cells by ATB0 transporter
type: Reaction

metaR MTHFD2
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.5.4.9
kinetic law: MODEL1310110007#
is: SBO:0000176
name: methylenetetrahydrofolate dehydrogenase (NAD)
product: MODEL1310110007#
reversible: true
is described by: ECO:0000134
type: Reaction
fast: false
modifier: MODEL1310110007#
reactant: MODEL1310110007#

metaR VLCSp
modifier: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
is: SBO:0000176
product: MODEL1310110007#
is described by: ECO:0000269
name: Very-long-chain-fatty-acid-CoA ligase
kinetic law: MODEL1310110007#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is version of: http://identifiers.org/ec-code/6.2.1.3

metaM 5adtststerones e
name: 5alpha-Dihydrotestosterone sulfate
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB06278
boundary condition: false
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_be389a4d_946b_4650_be00_ec3253fabd8b
is: SBO:0000252
boundary condition: true
is: O15327
constant: false
initial concentration: NaN
name: INPP4B
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:8821

http://identifiers.org/biomodels.db/MODEL1310110007#_e6b7de7c_23ce_4533_b6df_4757592a843e
is encoded by: hsa:112724
is: B3KVA3
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
name: RDH13
has only substance units: false
boundary condition: true

metaR r0423
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
product: MODEL1310110007#
is described by: ECO:0000000
modifier: MODEL1310110007#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#

metaM 6dhf l
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
is: SBO:0000247
initial concentration: 1.0
is: HMDB06563
boundary condition: false
type: Species
initial amount: NaN
name: hexaglutamyl folate (DHF)
constant: false
has only substance units: false

metaM glyphe e
notes: FORMULA: C11H14N2O3 CHARGE: 0
initial concentration: 1.0
boundary condition: false
name: Glycylphenylalanine
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/97415
initial amount: NaN
is: SBO:0000247
constant: false

metaM 4mzym int1 r
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
name: 4-Methylzymosterol intermediate 1
boundary condition: false
type: Species
is: HMDB06927
is: SBO:0000247

metaR SCPx
reactant: MODEL1310110007#
fast: false
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110007#
reversible: false
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.3.1.176
type: Reaction
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
kinetic law: MODEL1310110007#
name: peroxisomal thiolase 2

metaM ibcoa m
has only substance units: false
type: Species
is: HMDB01243
is: CHEBI:57338
boundary condition: false
constant: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
initial amount: NaN
name: isobutyryl-CoA(4-)
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_6757e927_2d43_425d_98fb_166a324bf6d5
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR CHATn
reversible: true
fast: false
kinetic law: MODEL1310110007#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
name: Choline O-acetyltransferase
is: SBO:0000176
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.3.1.6
type: Reaction
product: MODEL1310110007#
reactant: MODEL1310110007#

metaR FAOXC10C8x
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

metaR SERDGLNexR
fast: false
modifier: MODEL1310110007#
type: Reaction
name: D-Serine/Glutamine reversible exchange
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000185
reactant: MODEL1310110007#
reversible: true
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaM dhcholestancoa x
initial concentration: 1.0
is: CHEBI:15494
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
initial amount: NaN
boundary condition: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
type: Species
is: HMDB02159

metaR r1591
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_5b7d7277_b36e_4718_8198_d48e08158f21
name: PIK3R5:PIK3CG
initial concentration: NaN
has only substance units: false
has part: Q8WYR1
boundary condition: true
constant: false
is encoded by: hsa:23533
is: SBO:0000297
type: Species
initial amount: NaN

metaM prpncoa m
boundary condition: false
initial concentration: 1.0
name: acryloyl-CoA(4-)
constant: false
is: HMDB02307
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
has only substance units: false
is: CHEBI:57367

metaM pser L c
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
is: CHEBI:15811
name: O-Phospho-L-serine
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: HMDB01721

metaR r2520
is described by: ECO:0000000
product: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
fast: false

metaR r1512
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
product: MODEL1310110007#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Utilized transport
type: Reaction

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaR r0580
reactant: MODEL1310110007#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.7
product: MODEL1310110007#
type: Reaction
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30

metaR r0424
modifier: MODEL1310110007#
fast: false
product: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.17.1.4
type: Reaction
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
reversible: true
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#

metaR RE3568C
kinetic law: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
product: MODEL1310110007#
type: Reaction
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110007#
name: RE3568

metaM h2o2 n
constant: false
initial amount: NaN
is: HMDB03125
name: hydrogen peroxide
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial concentration: 1.0

metaR r2521
reactant: MODEL1310110007#
is described by: ECO:0000000
fast: false
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110007#
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_9a1234f1_4de9_4513_a073_a40e4d5b1cac
constant: false
initial concentration: NaN
name: QPRT
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:23475
is: Q15274
boundary condition: true
type: Species

metaR r0638
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.8.1.2
modifier: MODEL1310110007#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
is: SBO:0000176
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction

metaR r1590
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110007#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
product: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_994ce0b0_339f_4685_83cb_f1b5b1ef4b75
is encoded by: hsa:1337
is: P12074
type: Species
has only substance units: false
name: COX6A1
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_c34ef6e3_565a_40ca_884a_b85ea8a8e20d
boundary condition: true
initial concentration: NaN
name: ECI2
type: Species
is: O75521
is encoded by: hsa:10455
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_9199bf92_a12c_4940_826f_2622bc8fbffb
is: SBO:0000252
is: O43488
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8574
type: Species
boundary condition: true
constant: false
initial amount: NaN
name: AKR7A2

http://identifiers.org/biomodels.db/MODEL1310110007#_d71ec51f_da2f_425c_b59e_919df74d6356
is: SBO:0000252
type: Species
is: P30520
boundary condition: true
constant: false
initial concentration: NaN
name: ADSS
initial amount: NaN
has only substance units: false
is encoded by: hsa:159

http://identifiers.org/biomodels.db/MODEL1310110007#_ebd0347c_8a48_4960_ac2b_87f9249a8838
boundary condition: true
is: SBO:0000252
constant: false
type: Species
is: B4E3E9
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4967
initial amount: NaN
name: OGDH

metaM dhor S c
name: (S)-dihydroorotate
has only substance units: false
is: HMDB03349
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:30864

http://identifiers.org/biomodels.db/MODEL1310110007#_b0c7d258_0d2e_4dbd_b8ee_98f12c85970f
is: O43181
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: NDUFS4
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:4724

metaR Htr
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
name: H transporter, endoplasmic reticulum

metaR GALt2 2
product: MODEL1310110007#
is: SBO:0000185
name: D-galactose transport via proton symport
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110007#
is described by: ECO:0000269
kinetic law: MODEL1310110007#
reversible: true

metaR r0434
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
kinetic law: MODEL1310110007#
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110007#
reactant: MODEL1310110007#
modifier: MODEL1310110007#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
fast: false
is: SBO:0000176

metaM HC01434 m
name: oxalatosuccinate(3-)
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial concentration: 1.0
type: Species
is: CHEBI:58931

metaR r1593
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110007#
type: Reaction
fast: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR FATP7t
is: SBO:0000185
modifier: MODEL1310110007#
name: fatty acid electroneutral transport
kinetic law: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110007#
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/6.2.1.7
type: Reaction
is described by: ECO:0000000

MODEL1310110007#
species: metaM adprbp e
species: metaM nac c
species: metaM prostgf2 c
species: metaM itp n
species: metaM accoa x
species: metaM nad x
species: metaM HC01397 m
species: metaM dd2coa m
species: metaM HC00718 c
species: metaM his L c
species: metaM inost c
species: metaM acmana r
species: metaM g3m8masn r
stoichiometry: 0.286078
species: metaM asn L c
species: metaM HC02216 c
species: metaM cbasp c
species: metaM CE2432 m
species: metaM L2aadp6sa c
species: metaM HC01609 e
species: metaM arachcoa m
species: metaM 5htrp c
species: metaM Rtotal c
species: metaM occoa m
species: metaM Rtotal2 e
species: metaM dhlam m
species: metaM xyl D c
species: metaM CE5101 m
species: metaM mercplaccys e
species: metaM aicar e
species: metaM ade c
species: metaM pep m
species: metaM CE5586 c
species: metaM 5thf e
species: metaM mal L m
species: metaM ppcoa x
species: metaM ei11ecoa x
species: metaM Ser Gly Ala X Gly l
species: metaM dcmp n
species: metaM glyc3p c
species: metaM CE5120 m
species: metaM spmd c
species: metaM man r
species: metaM nad m
species: metaM HC01406 m
species: metaM nadph r
species: metaM dectricoa m
species: metaM pmtcoa x
species: metaM glu5sa m
species: metaM dctp n
species: metaM m6masnB2 g
stoichiometry: 0.017486
species: metaM h2o m
species: metaM chsterol e
species: metaM leu L e
species: metaM gullac r
species: metaM CE5791 e
species: metaM 3hmp m
species: metaM hxan e
species: metaM pram c
species: metaM lac L c
species: metaM crn r
species: metaM 2dodtricoa m
species: metaM gly c
species: metaM hs deg22 l
species: metaM ksi deg35 l
species: metaM phe L e
species: metaM 3ohdcoa x
name: PIK3CB:PIK3R1
species: metaM 3odcoa m
species: metaM 7dhchsterol c
species: metaM dhor S c
species: metaM 13 cis retn r
species: metaM val L e
species: metaM bildglcur c
species: metaM ksi deg22 l
species: metaM ha deg1 l
species: metaM cit e
species: metaM aicar c
species: metaM 12ppd S c

metaR XYLtly
reversible: false
kinetic law: MODEL1310110007#
name: Xylose efflux from lysosome
reactant: MODEL1310110007#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
type: Reaction
product: MODEL1310110007#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_9bf6de8c_cf01_4528_adf1_c17d879bc2ae
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P07864
is encoded by: hsa:3948
boundary condition: true
initial amount: NaN
constant: false
name: LDHC
type: Species

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_efb2f64a_dbd5_4642_bcdc_f34aa7feebaa
is: P00918
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: CA2
has only substance units: false
boundary condition: true
is encoded by: hsa:760

http://identifiers.org/biomodels.db/MODEL1310110007#_d0ebcce6_5e81_44e0_a8fd_acabda12da95
name: CA13
is: Q8N1Q1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:377677

metaR RTOTALt
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
name: RTOTAL transport
type: Reaction
kinetic law: MODEL1310110007#

metaR S2TASE2ly
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110007#
type: Reaction
modifier: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110007#
name: iduronate-2-sulfatase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.13

metaM gln L c
is: SBO:0000247
name: L-glutamine
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
initial amount: NaN
is: CHEBI:18050
is: HMDB00641
boundary condition: false

metaR M13N2Tg
kinetic law: MODEL1310110007#
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.4.1.101
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
reversible: false
is described by: ECO:0000000
product: MODEL1310110007#
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD

metaM CE5118 m
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:57923
constant: false
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
initial amount: NaN
is: SBO:0000247

metaR UDPGLCter
is described by: ECO:0000000
reactant: MODEL1310110007#
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
reversible: true
kinetic law: MODEL1310110007#
product: MODEL1310110007#
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD

metaR ABUTD
product: MODEL1310110007#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110007#
type: Reaction
name: Aminobutyraldehyde dehydrogenase
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
kinetic law: MODEL1310110007#
reversible: false
reactant: MODEL1310110007#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3

metaR GSNt
fast: false
reversible: true
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
name: guanosine facilated transport in cytosol
is described by: ECO:0000269
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is: SBO:0000185
modifier: MODEL1310110007#

metaM CE2416 x
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: (2R,6S,10S)-pristanate
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:57923
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)/p-1/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: CE2416

metaR r1592
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110007#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_6a77ca20_3cc1_4463_9983_ee66b772366b
name: MTHFD1L
initial amount: NaN
has only substance units: false
boundary condition: true
is: B2RD24
constant: false
is: SBO:0000252
is encoded by: hsa:25902
initial concentration: NaN
type: Species

metaM crm hs g
name: N-acylsphingosine
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: SBO:0000247
is: CHEBI:52639

metaR ACHEe
modifier: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000269
reversible: false
name: Acetylcholinesterase
is version of: http://identifiers.org/ec-code/3.1.1.7
reactant: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110007#
is: SBO:0000176

metaR MDRPD
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:JLR- Based on reaction given for B. subtilis (Sekowska A and A. Danchin paper(2002) )
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110007#
product: MODEL1310110007#
reversible: false
is: SBO:0000176
name: 5-Methylthio-5-deoxy-D-ribulose 1-phosphate dehydratase
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_034614a8_6ba5_42c6_bac4_ac6c44ed2453
is: Q9GZV3
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
name: SLC5A7
is encoded by: hsa:60482
is: SBO:0000252

metaM tdcoa x
initial amount: NaN
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01521
is: CHEBI:57385
has only substance units: false
is: C02593
constant: false
name: Tetradecanoyl-CoA (n-C14:0CoA)

metaR r2142
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110007#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110007#

metaM dcmp c
boundary condition: false
is: C00239
is: HMDB01202
name: dCMP
type: Species
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: CHEBI:57566
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM pristcoa c
constant: false
is: CHEBI:51341
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: pristanoyl coa
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
boundary condition: false
type: Species

metaM 5adtststerone c
is: CHEBI:16330
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: HMDB02961
is: SBO:0000247
name: 17beta-hydroxy-5alpha-androstan-3-one
initial amount: NaN
constant: false

metaR r2141
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
product: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000185
reactant: MODEL1310110007#

metaM cholp g
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: C00588
has only substance units: false
is: CHEBI:295975
is: SBO:0000247
name: choline phosphate(1-)

metaM hLkynr c
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
initial concentration: 1.0
is: HMDB11631
boundary condition: false
is: SBO:0000247
name: 3-hydroxy-L-kynurenine
has only substance units: false
is: CHEBI:17380
type: Species
initial amount: NaN
constant: false

metaR NCAMDe
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinamide at the basolateral surface
type: Reaction

metaR B3GALT3g
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.79
is: SBO:0000176
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110007#
is described by: ECO:0000269
product: MODEL1310110007#
kinetic law: MODEL1310110007#
name: Beta-1,3-galactosyltransferase 3
modifier: MODEL1310110007#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110007#_93910f34_6d00_479c_abfb_142fe8c20c60
is encoded by: hsa:6389
boundary condition: true
name: SDHA
initial concentration: NaN
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: P31040
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_efb24def_b0e8_4980_9f29_378a0ad0cfed
is: Q9NVS9
is encoded by: hsa:55163
boundary condition: true
constant: false
type: Species
name: PNPO
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR RE2972M
name: RE2972
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.1.67
type: Reaction
is: SBO:0000176
fast: false
reversible: true
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
is described by: ECO:0000000
product: MODEL1310110007#
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_a2ddd95e_1071_45ef_90d5_523688037bcd
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:1491
initial amount: NaN
boundary condition: true
name: CTH
type: Species
is: B4E1R2
has only substance units: false

metaR GLYCt
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
name: glycerol transport via channel
product: MODEL1310110007#
reversible: true
fast: false
kinetic law: MODEL1310110007#
is described by: ECO:0000000
reactant: MODEL1310110007#

metaM crm hs c
initial concentration: 1.0
name: N-acylsphingosine
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: CHEBI:52639

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaR EX fucgalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fucosyl galactosylgloboside (homo sapiens) exchange
type: Reaction

metaR r0999
is: SBO:0000185
type: Reaction
name: Facilitated diffusion
fast: false
reversible: true
reactant: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaR RE2660N
name: RE2660
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.96
is: SBO:0000176
kinetic law: MODEL1310110007#
reversible: true
modifier: MODEL1310110007#
reactant: MODEL1310110007#
product: MODEL1310110007#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_6884654e_6d85_4912_a344_7d93d19fab02
is: SBO:0000252
boundary condition: true
constant: false
name: ACOT1
initial concentration: NaN
has only substance units: false
is: E9KL42
type: Species
is encoded by: hsa:641371
initial amount: NaN

metaM h2o2 c
type: Species
is: C00027
is: SBO:0000247
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: CHEBI:16240
name: Hydrogen peroxide
boundary condition: false
is: HMDB03125
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR RE2649C
is: SBO:0000176
is described by: ECO:0000000
fast: false
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
name: RE2649
reversible: true

metaR DURIt
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
name: deoxyuridine transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110007#_0ebbf887_eb2a_4d9b_91a8_3e9d87a76329
is encoded by: hsa:5464
name: PPA1
is: SBO:0000252
is: Q15181
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false

metaM gln L m
is: CHEBI:18050
is: HMDB00641
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
name: L-glutamine

metaR RTOTALFATPc
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

metaM acac c
is: SBO:0000247
constant: false
is: HMDB00060
initial amount: NaN
name: acetoacetate
type: Species
has only substance units: false
is: CHEBI:13705
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164

metaR PPA
reversible: false
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.6.1.1
reactant: MODEL1310110007#
is described by: ECO:0000269
name: inorganic diphosphatase
modifier: MODEL1310110007#

metaR r2140
reversible: true
product: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110007#

metaR HGNTOR
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
is version of: http://identifiers.org/ec-code/1.13.11.5
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reversible: false
reactant: MODEL1310110007#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110007#
is described by: ECO:0000269

metaM anth c
is: SBO:0000247
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
initial concentration: 1.0
constant: false
name: anthranilate
initial amount: NaN
type: Species
has only substance units: false
is: HMDB01123
boundary condition: false
is: CHEBI:16567

http://identifiers.org/biomodels.db/MODEL1310110007#_49ed345a_cd3c_4d21_8291_3be9d6a6c924
constant: false
is: SBO:0000252
initial amount: NaN
is: Q9BYZ2
is encoded by: hsa:92483
type: Species
name: LDHAL6B
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR ADSS
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
name: adenylosuccinate synthase
reversible: false
modifier: MODEL1310110007#
is described by: ECO:0000134
product: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/6.3.4.4
kinetic law: MODEL1310110007#

metaM orn e
notes: FORMULA: C5H13N2O2 CHARGE: 1
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00214
initial concentration: 1.0
name: Ornithine
type: Species
is: CHEBI:0
is: C01602
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_decad1f1_74c3_45d7_9b8d_e5d4134a077f
name: _BF195998_1_x
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:BF195998
initial amount: NaN
type: Species
initial concentration: NaN

metaR r2525
is described by: ECO:0000000
kinetic law: MODEL1310110007#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaR r0998
name: Facilitated diffusion
fast: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110007#

metaM pan4p c
initial amount: NaN
is: C01134
is: SBO:0000247
name: Pantetheine 4'-phosphate
boundary condition: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial concentration: 1.0
is: CHEBI:47942
constant: false
type: Species
has only substance units: false
is: HMDB01416

metaR r0840
type: Reaction
modifier: MODEL1310110007#
product: MODEL1310110007#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.14.13.70
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
fast: false
kinetic law: MODEL1310110007#
is: SBO:0000185
name: Free diffusion

metaR r0784
is: SBO:0000176
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.38
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reversible: true
reactant: MODEL1310110007#
fast: false
product: MODEL1310110007#
is described by: ECO:0000000
type: Reaction

metaM thcholstoic x
is: CHEBI:18402
boundary condition: false
is: HMDB03873
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR PNTEH
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
is described by: ECO:0000269
fast: false
product: MODEL1310110007#
reversible: false
reactant: MODEL1310110007#
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.5.1.92
is: SBO:0000176
type: Reaction
name: Hydrolase Class ( RXN R02973)

http://identifiers.org/biomodels.db/MODEL1310110007#_73bed835_9c0c_4053_982e_0827cd044a3d
boundary condition: true
is: SBO:0000252
is: Q9NWU1
name: OXSM
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:54995
initial amount: NaN
type: Species

metaM b2coa m
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
name: crotonoyl-CoA(4-)
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
is: CHEBI:57332
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB02009

http://identifiers.org/biomodels.db/MODEL1310110007#_b37892e2_391f_4488_b031_812f233929b2
initial concentration: NaN
constant: false
name: BDH1
boundary condition: true
has only substance units: false
is encoded by: hsa:622
type: Species
is: SBO:0000252
initial amount: NaN
is: Q02338

metaR r0639
is: SBO:0000176
fast: false
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
type: Reaction
reversible: false
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
kinetic law: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#

metaM cala c
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
name: N-carbamoyl-beta-alaninate
boundary condition: false
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
is: HMDB00026
has only substance units: false
is: CHEBI:11892

metaR LTA4H
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
reactant: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.3.2.6
kinetic law: MODEL1310110007#
reversible: false
fast: false
type: Reaction
is described by: ECO:0000134
name: Leukotriene A-4 hydrolase
modifier: MODEL1310110007#
product: MODEL1310110007#

metaR DNDPt8m
modifier: MODEL1310110007#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110007#
fast: false
reversible: false
name: dADP transport via dUDP antiport
reactant: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR GLNLASEer
product: MODEL1310110007#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
kinetic law: MODEL1310110007#
is described by: ECO:0000000
reactant: MODEL1310110007#
name: gluconolactonase, endoplasmic reticulum
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110007#_01f56e3f_f6d1_4837_a9ef_2907439fa1a2
has only substance units: false
name: PANK2
initial amount: NaN
is: SBO:0000252
is: Q6P1K9
type: Species
is encoded by: hsa:80025
constant: false
boundary condition: true
initial concentration: NaN

metaR PHETHPTOX2
modifier: MODEL1310110007#
fast: false
is version of: http://identifiers.org/ec-code/1.14.16.1
reactant: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395
type: Reaction
kinetic law: MODEL1310110007#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
reversible: false
product: MODEL1310110007#

metaR FUCGALGBSIDEte
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
reversible: true
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
name: fucgalgbside hs transport
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction

metaR MTRI
is: SBO:0000176
name: 5-methylthioribose-1-phosphate isomerase
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 5.3.1.23 Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:
reactant: MODEL1310110007#
reversible: true
fast: false
kinetic law: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110007#

metaM orn c
is: CHEBI:0
is: HMDB00214
notes: FORMULA: C5H13N2O2 CHARGE: 1
name: Ornithine
initial amount: NaN
is: C01602
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247

metaM 5adtststerones c
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
is: HMDB06278
name: 5alpha-Dihydrotestosterone sulfate
initial amount: NaN
constant: false
has only substance units: false

metaM h2o2 e
is: SBO:0000247
is: CHEBI:16240
name: hydrogen peroxide
is: HMDB03125
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial concentration: 1.0
has only substance units: false
type: Species

metaM dgtp n
is: HMDB01440
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial concentration: 1.0
name: dGTP
is: C00286
is: CHEBI:16497
has only substance units: false
boundary condition: false

metaM 5adtststerone e
constant: false
is: SBO:0000247
is: CHEBI:16330
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
name: 17beta-hydroxy-5alpha-androstan-3-one
is: HMDB02961
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial amount: NaN

metaR r0787
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
is version of: http://identifiers.org/ec-code/1.1.1.1
reversible: false
reactant: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
fast: false
kinetic law: MODEL1310110007#
type: Reaction
modifier: MODEL1310110007#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110007#_90e04790_7a46_47cf_9d25_1f6fd19ace14
boundary condition: true
is encoded by: hsa:5092
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
name: PCBD1

metaM CE5121 m
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:57449
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
has only substance units: false
constant: false
name: trans-3-decenoyl-CoA

metaR r1881
modifier: MODEL1310110007#
reactant: MODEL1310110007#
reversible: false
kinetic law: MODEL1310110007#
type: Reaction
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110007#

metaR CYTDK2m
name: cytidine kinase (ATP), mitochondrial
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
product: MODEL1310110007#
reversible: false
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110007#_f5943ae3_e4c1_494c_9617_5429e446a887
is: O43306
type: Species
has only substance units: false
is encoded by: hsa:112
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
name: ADCY6
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_42a6193a_3473_4653_97ee_5bf3eead9646
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q9HAB8
name: PPCS
has only substance units: false
type: Species
is encoded by: hsa:79717

metaM mag hs c
is: HMDB12130
name: monoacylglycerol 2
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
is: CHEBI:16987
has only substance units: false
initial amount: NaN
constant: false

metaM 2amac c
is: HMDB03609
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C3H5NO2 CHARGE: 0 INCHI: InChI=1S/C3H5NO2/c1-2(4)3(5)6/h1,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00906 EHMN_ABBREVIATION: C02218
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17123
type: Species
name: 2-aminoacrylic acid

metaM 5aizc c
is: HMDB06273
is: C04751
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
boundary condition: false
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
initial concentration: 1.0
constant: false
is: CHEBI:58564

metaR FAOXC161C141x
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C16:1-->C14:1)x
type: Reaction

metaM acac e
is: HMDB00060
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
constant: false
name: acetoacetate
is: CHEBI:13705
initial concentration: 1.0

metaM 25aics c
initial concentration: 1.0
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
boundary condition: false
is: SBO:0000247
is: CHEBI:58443
has only substance units: false
is: C04823
constant: false
is: HMDB00797
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_a5caac6f_4808_479d_b4ff_1253fee645e8
boundary condition: true
is: Q05932
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:2356
name: FPGS
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_9637a607_00c2_4419_94ae_06e9df8e4a1c
is encoded by: hsa:376497
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
name: SLC27A1
is: Q6PCB7
initial amount: NaN
has only substance units: false
type: Species

metaR RE0452M
product: MODEL1310110007#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
type: Reaction
kinetic law: MODEL1310110007#
name: RE0452
fast: false
reactant: MODEL1310110007#
is described by: ECO:0000000

metaR ADK1
fast: false
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110007#
type: Reaction
reversible: true
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110007#
product: MODEL1310110007#
name: adenylate kinase
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM dece4coa m
type: Species
is: HMDB02145
has only substance units: false
name: 4-decenoylcoa
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0

metaM 2mop c
is: CHEBI:57700
boundary condition: false
has only substance units: false
name: 2-methyl-3-oxopropanoate
is: SBO:0000247
constant: false
is: HMDB01172
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_9c3f6155_0cc7_4e6a_934c_7bb422b729d4
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P00505
type: Species
initial concentration: NaN
is encoded by: hsa:2806
has only substance units: false
name: GOT2

metaR EX paf hs LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
type: Reaction

metaR PROSTGI2t
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
type: Reaction
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is: SBO:0000185
name: Prostaglandin I2 transport
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_3c0f4102_13fc_4b6b_972f_eb52040a7187
boundary condition: true
is encoded by: hsa:6821
is: P51687
initial amount: NaN
name: SUOX
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN

metaR NCCt
fast: false
product: MODEL1310110007#
modifier: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000269
kinetic law: MODEL1310110007#
reversible: false
name: Na+-Cl- cotransport
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (6559.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739168,PMID:8528245,PMID:8670281,PMID:8812482 NOTES:NCD

metaR r1882
is: SBO:0000185
reactant: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
type: Reaction
name: Y+LAT2 Utilized transport
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110007#
reversible: false

metaM pan4p e
is: C01134
is: SBO:0000247
has only substance units: false
name: Pantetheine 4'-phosphate
boundary condition: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2
constant: false
is: CHEBI:47942
initial concentration: 1.0
type: Species
is: HMDB01416
initial amount: NaN

metaR NRPPHRSULT
modifier: MODEL1310110007#
name: Norepinephrine Sulfotransferase
fast: false
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
product: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.8.2.1
kinetic law: MODEL1310110007#
is: SBO:0000176

metaR PNTOte
fast: false
is described by: ECO:0000134
product: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
name: Transport of (R)-Pantothenate
kinetic law: MODEL1310110007#

metaR RE1807C
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110007#
reversible: true
name: RE1807
kinetic law: MODEL1310110007#
is: SBO:0000176
fast: false
product: MODEL1310110007#
type: Reaction

metaM taur x
is: HMDB00251
boundary condition: false
is: CHEBI:15891
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
type: Species
name: taurine
initial concentration: 1.0
initial amount: NaN

metaR MDHm
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.37
modifier: MODEL1310110007#
reversible: true
fast: false
is described by: ECO:0000134
name: malate dehydrogenase, mitochondrial
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_fac2b518_67bd_4cd0_ab6f_c93aafa76adf
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:587
name: BCAT2
is: O15382
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_6fea4d50_ca39_44aa_adbf_4473b7f99101
initial concentration: NaN
name: SLC5A3
type: Species
constant: false
is encoded by: hsa:6526
has only substance units: false
is: P53794
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM ksi deg20 l
is: CHEBI:12936
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
name: keratan sulfate I, degradation product 20
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
is: HMDB00143
constant: false

metaM cholp c
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: choline phosphate(1-)
boundary condition: false
is: CHEBI:295975
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588

metaM asn L c
is: CHEBI:17196
has only substance units: false
initial amount: NaN
name: L-asparagine
is: HMDB00168
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247

metaR r2080
product: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110007#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110007#

metaM HC01434 x
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
has only substance units: false
boundary condition: false
is: CHEBI:58931
type: Species
initial amount: NaN
name: oxalatosuccinate(3-)
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR ALADGLYexR
reactant: MODEL1310110007#
reversible: true
product: MODEL1310110007#
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
modifier: MODEL1310110007#
name: D-alanine/glycine reversible exchange

metaM CE5586 c
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
boundary condition: false
is: CHEBI:58732
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaR FUCGALGBSIDEtg
fast: false
product: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
is: SBO:0000185
is described by: ECO:0000000
name: fucgalgbside hs intracellular transport
type: Reaction
reversible: true
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_d2d5b4ee_0ffc_4e7b_832f_a24d924cde58
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:H53099
name: _H53099_1_m
constant: false

metaM m4mpdol L r
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
is: CHEBI:37633
type: Species
has only substance units: false
is: SBO:0000247
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false

metaR SPHMYLNtg
is described by: ECO:0000000
name: sphingomyelin intracellular transport
kinetic law: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
type: Reaction
fast: false
product: MODEL1310110007#
reversible: true
reactant: MODEL1310110007#

metaR CYTK8n
fast: false
name: cytidylate kinase (CMP,dATP),nuclear
is described by: ECO:0000269
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reactant: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110007#_e993e56d_9ce0_4601_9d20_c52e0ec933b5
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species
is: Q5SPY7
name: ENTPD2
is encoded by: hsa:954
boundary condition: true
initial amount: NaN

metaR GULLACter
is: SBO:0000185
product: MODEL1310110007#
reactant: MODEL1310110007#
reversible: false
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110007#
name: gulonolactone endoplasmic reticular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES:NCD

metaR r0781
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110007#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
kinetic law: MODEL1310110007#
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
reactant: MODEL1310110007#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_3895aa56_453c_4178_896e_df4a7217f583
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4712
constant: false
name: NDUFB6
initial amount: NaN
initial concentration: NaN
type: Species
is: O95139
has only substance units: false

metaR Htx
reversible: true
product: MODEL1310110007#
reactant: MODEL1310110007#
name: H transporter, peroxisome
kinetic law: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
fast: false

metaM CE2422 m
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
is: CHEBI:28387
type: Species
is: HMDB11123

metaM gua e
boundary condition: false
is: CHEBI:16235
has only substance units: false
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
name: guanine
type: Species
is: HMDB00132
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM sphmyln hs g
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
boundary condition: false
name: sphingomyelin betaine
initial amount: NaN
is: CHEBI:58216
constant: false
is: SBO:0000247

metaR r0917
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110007#
fast: false
type: Reaction
product: MODEL1310110007#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110007#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_dc9bf125_d69a_48c7_ae41_d62388cdf1d3
boundary condition: true
name: ALG1
is encoded by: hsa:56052
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is: Q9BT22
initial concentration: NaN
has only substance units: false

metaR RE3524R
reactant: MODEL1310110007#
product: MODEL1310110007#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
name: RE3524
kinetic law: MODEL1310110007#
fast: false
type: Reaction

metaR 5OXPROt
reactant: MODEL1310110007#
name: Transport of 5-oxoprolinate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110007#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110007#
is described by: ECO:0000134
type: Reaction
reversible: true

metaR r1400
product: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
is described by: ECO:0000000
name: Active transport
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
reversible: false

metaR EX nad LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide adenine dinucleotide exchange
type: Reaction

metaR r2081
type: Reaction
fast: false
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110007#
product: MODEL1310110007#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000

metaR AK2LGCHOLt
name: 1-alkyl 2-acylglycerol 3-phosphocholine transport
fast: false
is: SBO:0000185
kinetic law: MODEL1310110007#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.1.1.21 Confidence Level: 2 AUTHORS: PMID:2004782,PMID:2253271,PMID:8106516 NOTES:
product: MODEL1310110007#
type: Reaction
reversible: true
reactant: MODEL1310110007#

metaR r0994
product: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
is: SBO:0000185
type: Reaction
name: Facilitated diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
reactant: MODEL1310110007#
is described by: ECO:0000000

metaM ptrc c
is: C00134
name: Putrescine
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
is: CHEBI:326268
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB01414

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaR ADK3
modifier: MODEL1310110007#
reversible: true
is: SBO:0000176
reactant: MODEL1310110007#
fast: false
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.3
product: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
name: adentylate kinase (GTP)

metaR r0780
kinetic law: MODEL1310110007#
is: SBO:0000176
fast: false
reversible: true
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
modifier: MODEL1310110007#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
reactant: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR biomass reaction
is: SBO:0000185
product: MODEL1310110007#
name: biomass_reaction
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
fast: false
reactant: MODEL1310110007#
reversible: false
is described by: ECO:0000134
type: Reaction

metaR r1899
reversible: false
product: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110007#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110007#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_3dc9cc75_1473_4730_a54a_8b9068f48582
is: Q7KYS4
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
name: PDE4C
is encoded by: hsa:5143
type: Species
is: SBO:0000252
initial amount: NaN

metaR r2526
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110007#
product: MODEL1310110007#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_21bdc50f_e383_45a0_affe_2ccba9f385ae
is: A8K5Z0
name: B4GALT3
is encoded by: hsa:8703
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR C226COAtx
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
kinetic law: MODEL1310110007#
name: fatty acid intracellular transport
reactant: MODEL1310110007#
type: Reaction
reversible: true
product: MODEL1310110007#

metaR DHORTS
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
modifier: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
reactant: MODEL1310110007#
reversible: true
name: dihydroorotase
fast: false
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.1.3.2
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_c0616a89_2fb2_4d17_923d_8c8db4bb8053
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4351
name: MPI
constant: false
type: Species
initial amount: NaN
is: P34949

metaR PTE3x
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.2.2
fast: false
reactant: MODEL1310110007#
name: peroxisomal acyl-CoA thioesterase
is: SBO:0000176
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
product: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_e16750da_cf3b_4349_a93a_9585102d1f0b
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:7296
has only substance units: false
initial concentration: NaN
is: Q16881
boundary condition: true
name: TXNRD1

http://identifiers.org/biomodels.db/MODEL1310110007#_38a492e9_e876_4d74_8950_32c07ce4f67c
name: PHYH
constant: false
is encoded by: hsa:5264
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: O14832
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_bcf2386b_99aa_4f85_9eaa_f0ce6f95b53b
has only substance units: false
is: P47895
name: ALDH1A3
initial amount: NaN
is encoded by: hsa:220
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_0e048ffd_5ac8_4c50_868b_0b51f4c6e527
name: ENPP1
initial amount: NaN
is encoded by: hsa:5167
initial concentration: NaN
boundary condition: true
is: P22413
has only substance units: false
type: Species
is: SBO:0000252
constant: false

metaM acnamp c
type: Species
constant: false
boundary condition: false
is: HMDB06268
has only substance units: false
name: N-Acetylneuraminate 9-phosphate
initial amount: NaN
is: SBO:0000247
is: CHEBI:27438
notes: FORMULA: C11H17NO12P CHARGE: -3 INCHI: InChI=1S/C11H20NO12P/c1-4(13)12-7-5(14)2-11(19,10(17)18)24-9(7)8(16)6(15)3-23-25(20,21)22/h5-9,14-16,19H,2-3H2,1H3,(H,12,13)(H,17,18)(H2,20,21,22)/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01734 EHMN_ABBREVIATION: C06241
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_a1b1f463_d125_414e_a51d_4b4f6c060ac0
type: Species
boundary condition: true
is: Q8N5Z0
is: SBO:0000252
initial concentration: NaN
constant: false
name: AADAT
initial amount: NaN
is encoded by: hsa:51166
has only substance units: false

metaR r2082
product: MODEL1310110007#
type: Reaction
modifier: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110007#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110007#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_820eaa73_7564_4fc7_baa5_ea99420f94f7
boundary condition: true
is: B4DR31
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:1808
name: DPYSL2
is: SBO:0000252
type: Species

metaR UMPK7n
is described by: ECO:0000269
kinetic law: MODEL1310110007#
name: UMP kinase (dGTP),nuclear
reactant: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110007#
type: Reaction
fast: false
product: MODEL1310110007#

metaR HIStN1
product: MODEL1310110007#
name: Histidine transport (Na, H coupled)
reversible: true
reactant: MODEL1310110007#
is described by: ECO:0000269
modifier: MODEL1310110007#
type: Reaction
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
fast: false
is: SBO:0000185

metaM asn L e
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00168
constant: false
name: L-asparagine
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: SBO:0000247
type: Species
is: CHEBI:17196
initial concentration: 1.0

metaR r0841
is: SBO:0000185
type: Reaction
product: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.271
kinetic law: MODEL1310110007#
is described by: ECO:0000000
reactant: MODEL1310110007#
name: Free diffusion
reversible: true
fast: false
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:

metaR r0783
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
modifier: MODEL1310110007#
fast: false
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
product: MODEL1310110007#
is described by: ECO:0000000
type: Reaction

metaM ddsmsterol r
initial amount: NaN
name: 7-dehydrodesmosterol
is: SBO:0000247
is: CHEBI:27910
boundary condition: false
has only substance units: false
is: HMDB03896
constant: false
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
type: Species
initial concentration: 1.0

metaR r0587
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
is described by: ECO:0000000
modifier: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110007#
reversible: true
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM pail34p hs c
initial concentration: 1.0
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
constant: false
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:57658
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_9065e8fe_32e1_41d1_848a_2f9ade5756cd
type: Species
name: MYO5B
initial amount: NaN
is: Q9H6Y6
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:4645
has only substance units: false

metaR GTHRDt
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
name: Glutathione transport into mitochondria
kinetic law: MODEL1310110007#
is: SBO:0000185
reversible: true
product: MODEL1310110007#
is described by: ECO:0000000
reactant: MODEL1310110007#

metaM anth e
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
name: anthranilate
has only substance units: false
is: HMDB01123
is: CHEBI:16567

metaR r2084
reactant: MODEL1310110007#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110007#
reversible: true
is described by: ECO:0000000
product: MODEL1310110007#
modifier: MODEL1310110007#

metaR r0915
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
kinetic law: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#
fast: false
reversible: true

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_80359e1f_7697_4b0d_b994_db999537180f
initial amount: NaN
is: P10619
is encoded by: hsa:5476
type: Species
constant: false
boundary condition: true
has only substance units: false
name: CTSA
is: SBO:0000252
initial concentration: NaN

metaR r0842
fast: false
product: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.3.1.72
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
name: Postulated transport reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_32bbce7b_9d6d_46c2_aa26_5c8a06984cbf
has only substance units: false
type: Species
constant: false
name: FUCA1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2517
is: P04066
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_4ed44ebe_0044_4c4a_8455_fb6c05176da4
initial concentration: NaN
name: ALDH2
initial amount: NaN
is: P05091
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:217
constant: false

metaR RE3270C
reversible: true
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000176
name: RE3270
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:IT - fixed proton
type: Reaction
fast: false
product: MODEL1310110007#
is described by: ECO:0000000

metaR SO4t4 2
type: Reaction
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
reactant: MODEL1310110007#
product: MODEL1310110007#
reversible: true
fast: false
is: SBO:0000185
modifier: MODEL1310110007#
name: sulfate transport via sodium symport
kinetic law: MODEL1310110007#
is described by: ECO:0000269

metaM dcsptn1crn c
initial concentration: 1.0
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
constant: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
name: docosa-4,7,10,13,16-pentaenoyl carnitine
is: HMDB06321

http://identifiers.org/biomodels.db/MODEL1310110007#_ad6a1e46_28ec_4598_a28e_c5e15546b240
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q16850
type: Species
boundary condition: true
name: CYP51A1
constant: false
is encoded by: hsa:1595
is: SBO:0000252

metaR PMEVKx
modifier: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#
type: Reaction
is described by: ECO:0000134
name: phosphomevalonate kinase
reactant: MODEL1310110007#
reversible: false
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.4.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
is version of: http://identifiers.org/ec-code/2.7.4.2
product: MODEL1310110007#
fast: false

metaR HAtly
name: hyaluronan transport, extracellular to lysosome
kinetic law: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110007#
reversible: false
product: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false

metaR EX malt LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltose exchange
type: Reaction

metaM bilirub r
name: bilirubin(2-)
boundary condition: false
initial amount: NaN
is: HMDB00054
type: Species
is: CHEBI:57977
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486

metaM nadph c
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate - reduced
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:57783
is: C00005
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00221

metaR GALt1r
type: Reaction
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD
product: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
reversible: true
is: SBO:0000185
name: galactose transport (uniport)
is described by: ECO:0000269
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#

metaM g3m8masn r
type: Species
has only substance units: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C88H147N2O70X CHARGE: 0
initial amount: NaN
is: C05873

metaR MALT
modifier: MODEL1310110007#
name: alpha-glucosidase
product: MODEL1310110007#
reversible: false
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.20
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2595.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:12370436,PMID:7018580 NOTES:IF
is described by: ECO:0000269
is: SBO:0000176

metaM pyr c
type: Species
is: C00022
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15361
boundary condition: false
is: http://identifiers.org/pubchem.compound/3324
constant: false
is: SBO:0000247
is: HMDB00243
notes: FORMULA: C3H3O3 CHARGE: -1
name: pyruvate

metaM pro L m
is: CHEBI:17203
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
name: L-proline
boundary condition: false
is: HMDB00162
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145

metaM HC00250 e
is: SBO:0000247
type: Species
is: CHEBI:29919
name: hydrosulfide
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283

metaM ca2 e
is: CHEBI:29108
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00464
initial amount: NaN
name: calcium(2+)
constant: false
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_f0d3f531_41da_453f_9f49_9bd34a806ce3
is encoded by: hsa:4967
is: SBO:0000297
constant: false
initial amount: NaN
boundary condition: true
type: Species
has part: Q02218
name: DLD:DLST:OGDH:PDHX
initial concentration: NaN
has only substance units: false

metaR ACNAMlt
is: SBO:0000185
name: N-acetylneuraminate transport into lysososme
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
kinetic law: MODEL1310110007#
product: MODEL1310110007#
type: Reaction
fast: false
modifier: MODEL1310110007#
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_525ee419_565a_4035_b32d_28a83ecd992c
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:10317
initial amount: NaN
name: B3GALT5
initial concentration: NaN
constant: false
type: Species

metaM C05957 r
type: Species
constant: false
boundary condition: false
name: Prostaglandin J2
initial amount: NaN
is: SBO:0000247
is: CHEBI:27485
is: HMDB02710
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_24df4261_3e7a_42d0_8b95_fcf733d35b2a
initial amount: NaN
name: PIK3C2B
is encoded by: hsa:5287
type: Species
is: O00750
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM pectindchac e
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C2559H3549O2539 CHARGE: -1
is: SBO:0000247
is: HMDB03402
boundary condition: false
has only substance units: false
name: pectin-deoxycholic acid complex
type: Species

metaM sucsal m
is: SBO:0000247
initial amount: NaN
name: Succinic semialdehyde
boundary condition: false
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
has only substance units: false
initial concentration: 1.0
is: CHEBI:57706
is: HMDB01259
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_cd0dd0f6_e48e_4e95_b04b_bb90237d6846
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:3158
constant: false
initial amount: NaN
is: P54868
name: HMGCS2
is: SBO:0000252
has only substance units: false

metaR SERGLYexR
modifier: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
fast: false
product: MODEL1310110007#
name: L-Serine/Glycine reversible exchange
kinetic law: MODEL1310110007#
reversible: true
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110007#_e714dd28_6568_4b52_ba8f_fc76c5c8452a
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
is: P04843
is encoded by: hsa:6184
name: RPN1
constant: false

metaM HC01410 m
constant: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
initial concentration: 1.0
name: (2E)-Hexenoyl-CoA
initial amount: NaN
has only substance units: false
is: CHEBI:28706
type: Species
is: SBO:0000247
boundary condition: false

metaM 5pmev x
initial amount: NaN
constant: false
type: Species
name: (R)-5-phosphonatomevalonate(3-)
has only substance units: false
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00670 EHMN_ABBREVIATION: C01107
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01343
is: CHEBI:58146

metaR r0149
fast: false
reversible: true
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
product: MODEL1310110007#
is: SBO:0000176
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.14.13.39
is described by: ECO:0000000
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_3ad8eea4_3142_435c_9541_59974bf956fb
name: ALAS2
is encoded by: hsa:212
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q5JZF5
initial amount: NaN

metaM dpcoa c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
name: Dephospho-CoA
is: C00882
type: Species
is: CHEBI:57328
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB01373
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_5fed7add_9250_4ba2_93b3_08422e9b0362
constant: false
is: SBO:0000252
name: CA9
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:768
is: Q16790

http://identifiers.org/biomodels.db/MODEL1310110007#_35c5c720_73a9_4e52_9c03_dac18ad1c010
is: Q6PXP3
name: SLC2A7
is encoded by: hsa:155184
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN

metaM Nacasp m
initial amount: NaN
constant: false
initial concentration: 1.0
name: N-acetyl-L-aspartate(2-)
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
type: Species
is: SBO:0000247
is: CHEBI:16953
has only substance units: false
boundary condition: false
is: HMDB00812

http://identifiers.org/biomodels.db/MODEL1310110007#_d6f1b4fa_ba55_4690_82ac_4db3323e5b8c
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:728226
name: _728226_1_e
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_89933b6e_0079_451e_a26d_716943c49e55
is encoded by: hsa:23632
type: Species
constant: false
name: CA14
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: A8K3J4
initial amount: NaN
boundary condition: true

metaM CE5236 c
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:28002
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: HMDB03952
boundary condition: false
name: O2'-4a-cyclic-tetrahydrobiopterin
has only substance units: false
is: SBO:0000247

metaR NDPK10
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:dIDP)
product: MODEL1310110007#
is described by: ECO:0000134
reactant: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
kinetic law: MODEL1310110007#
reversible: true
type: Reaction

metaR DTMPK
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.9
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reversible: true
fast: false
is described by: ECO:0000269
reactant: MODEL1310110007#
is: SBO:0000176
type: Reaction
name: dTMP kinase
product: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_0c71516f_62cf_4693_b027_9b6a801c3da0
is encoded by: hsa:2653
boundary condition: true
is: P23434
constant: false
type: Species
has only substance units: false
initial concentration: NaN
name: GCSH
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_c0a9768a_4740_475d_8c90_742300e67a1e
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
is: P04183
initial concentration: NaN
type: Species
name: TK1
constant: false
is encoded by: hsa:7083

metaM ksi deg27 l
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:12936
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate I, degradation product 27
is: HMDB00143
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
type: Species

metaR THMMPtm
fast: false
is: SBO:0000185
name: Thiamine monophosphate transport, mitochondrial
kinetic law: MODEL1310110007#
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12014993,PMID:9755848 NOTES:IT
reactant: MODEL1310110007#

metaM gdpddman c
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
has only substance units: false
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:57964
initial amount: NaN
is: HMDB01346
boundary condition: false
constant: false

metaR THRGLYexR
name: L-threonine/glycine reversible exchange
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110007#
fast: false
is: SBO:0000185
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_8015bdf6_0516_41d6_ab8a_e137631be5d7
is: Q13057
initial concentration: NaN
constant: false
is encoded by: hsa:80347
boundary condition: true
initial amount: NaN
name: COASY
is: SBO:0000252
type: Species
has only substance units: false

metaR r0942
product: MODEL1310110007#
reversible: true
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
is described by: ECO:0000000
fast: false
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110007#

metaM pi r
has only substance units: false
initial concentration: 1.0
is: CHEBI:43474
constant: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
type: Species
is: SBO:0000247
is: C00009
initial amount: NaN
boundary condition: false
name: hydrogenphosphate
is: HMDB00973

metaR r1164
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
reactant: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#
fast: false
type: Reaction
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110007#
name: EC:2.3.1.26

http://identifiers.org/biomodels.db/MODEL1310110007#_fe5f71ef_e887_4f01_bc2b_592d6f0a0f01
is: Q9HCQ5
is: SBO:0000252
name: GALNT9
has only substance units: false
initial amount: NaN
is encoded by: hsa:50614
type: Species
constant: false
boundary condition: true
initial concentration: NaN

metaR PHYHx
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.14.11.18
reactant: MODEL1310110007#
name: Phytanoyl-CoA dioxygenase, peroxisomal
product: MODEL1310110007#
type: Reaction
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110007#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5264.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.14.11.18 Confidence Level: 4 AUTHORS: PMID:8954107,PMID:9326940 NOTES:NJ

metaM btamp m
has only substance units: false
is: CHEBI:3110
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
name: Biotinyl-5'-AMP
is: HMDB04220

metaR S6TASE13ly
type: Reaction
product: MODEL1310110007#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
fast: false

metaR r0245
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: true
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110007#
reactant: MODEL1310110007#
modifier: MODEL1310110007#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72

metaM 4mzym int2 r
name: 4-Methylzymosterol intermediate 2
is: SBO:0000247
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: HMDB06838
boundary condition: false

metaM 3hmp m
name: 3-hydroxy-2-methylpropanoate
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00023
is: CHEBI:11805
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
has only substance units: false

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_66069e70_e509_4d02_9817_669ec0110144
is: SBO:0000252
initial concentration: NaN
is: Q9H903
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:441024
name: MTHFD2L
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_f1d9775d_11f8_4fa0_b138_d36109e2c598
has only substance units: false
is: E9PAY8
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8612
constant: false
name: PPAP2C

metaM amp r
initial amount: NaN
is: HMDB00045
name: AMP
constant: false
is: CHEBI:456215
is: C00020
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020

metaM co2 x
name: carbon dioxide
initial amount: NaN
is: HMDB01967
is: SBO:0000247
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:16526
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011

metaM camp c
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
type: Species
name: 3',5'-cyclic AMP(1-)
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:58165
boundary condition: false
initial concentration: 1.0
is: HMDB00058
is: SBO:0000247

metaR EX dag hs LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for diglyceride
type: Reaction

metaR S6TASE2ly
reversible: true
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110007#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#

metaR SIAASE4ly
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
product: MODEL1310110007#
is: SBO:0000176
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
modifier: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
name: sialidase, lysosomal

metaR RE1521M
reactant: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1521
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
reversible: true

metaM retinal cis 9 r
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB01358
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
is: CHEBI:17898
name: all-trans-retinal

http://identifiers.org/biomodels.db/MODEL1310110007#_bf729d81_7516_4d6b_a6f0_77687cde565d
initial concentration: NaN
is encoded by: hsa:23169
type: Species
constant: false
has only substance units: false
name: SLC35D1
is: Q9NTN3
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR HISSNAT5tc
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR r0246
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
product: MODEL1310110007#
reversible: false
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_b7027da2_33d8_4442_a9cc_2cd839c0ed01
is encoded by: hsa:54187
name: NANS
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false
is: Q9NR45
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_34959de8_c6d8_44bc_9d94_d8823da1ffa9
initial amount: NaN
type: Species
name: PDE8A
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:5151
constant: false

metaR r0944
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110007#
fast: false
type: Reaction
is: SBO:0000185
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110007#_9739f63a_8f1f_4fb3_87a6_d520b745825e
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1215
is: Q4FEB3
initial concentration: NaN
boundary condition: true
constant: false
name: CMA1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_457fe004_933c_46bd_969b_6a571033262e
initial amount: NaN
has only substance units: false
is: P00441
constant: false
name: SOD1
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6647

metaR ACALDt
kinetic law: MODEL1310110007#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110007#
name: acetaldehyde reversible transport
is: SBO:0000185
type: Reaction
product: MODEL1310110007#
fast: false

metaR SERHL
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.3.1.17
reversible: false
kinetic law: MODEL1310110007#
product: MODEL1310110007#
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:2674117 NOTES:MM
reactant: MODEL1310110007#
name: L-Serine hydro-lyase
modifier: MODEL1310110007#

metaM tetdecdicoa m
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB02288
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
type: Species
has only substance units: false
name: 5,8-tetradecadienoylcoa

metaM 5htrp c
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:17780
is: HMDB00472
name: 5-hydroxy-L-tryptophan
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643

metaR URCN
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reversible: false
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.2.1.49
name: URCN
is described by: ECO:0000269
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_bed2474b_4956_440b_b981_3d3ac745b253
has only substance units: false
is: Q59FD4
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
name: HK1
is encoded by: hsa:3098
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_c73ff920_acae_4de9_bc35_b1fadaf5cf07
is: SBO:0000252
initial concentration: NaN
name: SULT1A3
constant: false
initial amount: NaN
is encoded by: hsa:6818
type: Species
boundary condition: true
has only substance units: false

metaR CYTK12n
modifier: MODEL1310110007#
is described by: ECO:0000269
kinetic law: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110007#
name: cytidylate kinase (dCMP,dCTP),nuclear
is: SBO:0000176
fast: false

metaM tmndnccoa c
initial amount: NaN
name: timnodonyl coenzyme A
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB06514
has only substance units: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1

metaR CYANtm
name: Cyanide transport via diffusion (mitochondrial)
kinetic law: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
is: SBO:0000185
reversible: true

metaR r1842
reversible: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
product: MODEL1310110007#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_ba24f22d_e367_443b_823f_ac9a7f4a6dad
is encoded by: hsa:51
constant: false
name: ACOX1
has only substance units: false
is: B4DK61
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR ACHtn
reversible: true
is described by: ECO:0000000
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000185
fast: false
name: Acetylcholin transport, nuclear trhough pores
reactant: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it

metaR r0145
modifier: MODEL1310110007#
reactant: MODEL1310110007#
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.8.3.1
type: Reaction
product: MODEL1310110007#
reversible: true
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
is described by: ECO:0000000

metaM acgam1p c
type: Species
name: N-Acetyl-D-glucosamine 1-phosphate
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
is: CHEBI:7125
initial amount: NaN
is: SBO:0000247
is: HMDB01367

metaR RETNt
type: Reaction
is: SBO:0000185
fast: false
name: retinoic acid transport
reversible: true
reactant: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
kinetic law: MODEL1310110007#

metaR PRPNCOAHYDm
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000134
name: Propenoyl-CoA hydrolase (m)
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110007#
fast: false
is: SBO:0000176
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.2.1.18
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay

metaR r0946
product: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110007#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_94e3a49d_f864_45c9_a175_47712be726ae
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10948
is: B4DUY1
name: STARD3

metaM xol27oh r
name: 26-hydroxycholesterol
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: HMDB02103
has only substance units: false
is: CHEBI:17703

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaR EX gthox LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxidized glutathione exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_8185aa85_b68d_4b2a_b8bd_290257a6aafe
type: Species
boundary condition: true
name: ECH1
constant: false
is: Q13011
has only substance units: false
is encoded by: hsa:1891
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM 5mta c
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
constant: false
has only substance units: false
is: CHEBI:17509
initial concentration: 1.0
initial amount: NaN
is: C00170
is: HMDB01173
type: Species
boundary condition: false
name: 5-Methylthioadenosine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_dfbb84dd_f884_45f1_bfbc_c00bc6dcf753
is encoded by: hsa:374291
initial concentration: NaN
is: O75251
constant: false
name: NDUFS7
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_095618f6_c44b_4cf5_a2c6_b7797fdc92df
constant: false
has only substance units: false
initial concentration: NaN
is: Q99999
name: GAL3ST1
type: Species
is encoded by: hsa:9514
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR IPDDIx
type: Reaction
fast: false
reactant: MODEL1310110007#
reversible: true
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
name: isopentenyl-diphosphate D-isomerase
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/5.3.3.2

metaM HC00250 c
name: hydrosulfide
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
type: Species
is: CHEBI:29919
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_1655dacd_ae39_4ff3_b527_996edd61e521
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:4707
initial concentration: NaN
is: O75438
name: NDUFB1
is: SBO:0000252
type: Species

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaR r0086
reversible: false
product: MODEL1310110007#
is: SBO:0000176
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
type: Reaction
reactant: MODEL1310110007#
fast: false
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000000
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
is version of: http://identifiers.org/ec-code/3.5.1.3

metaM pi n
name: hydrogenphosphate
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
is: CHEBI:43474
is: HMDB00973
initial concentration: 1.0
boundary condition: false
constant: false

metaR r1453
product: MODEL1310110007#
reversible: true
reactant: MODEL1310110007#
is described by: ECO:0000000
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
kinetic law: MODEL1310110007#
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:

metaR r0142
is described by: ECO:0000000
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
kinetic law: MODEL1310110007#
reversible: false
fast: false
modifier: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110007#_658c931d_9a66_47d9_9588_02bef197041a
is: Q6IB80
name: NDUFB3
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4709
initial amount: NaN
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_3d562357_3370_4c72_b7a8_3d13a106e4cc
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:AL038231
initial amount: NaN
initial concentration: NaN
name: _AL038231_1_c

http://identifiers.org/biomodels.db/MODEL1310110007#_c874b0cf_feb3_42af_ad18_31031d32d22a
has only substance units: false
constant: false
type: Species
is encoded by: hsa:224
is: P51648
is: SBO:0000252
boundary condition: true
name: ALDH3A2
initial concentration: NaN
initial amount: NaN

metaR FAOXC61C4m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

metaM L2aadp c
boundary condition: false
is: CHEBI:58672
is: HMDB00510
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
constant: false
name: L-2-aminoadipate(1-)
is: SBO:0000247
type: Species
has only substance units: false

metaR NACHEX18ly
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110007#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110007#
reactant: MODEL1310110007#
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110007#
reversible: false

metaM 4h2oglt m
type: Species
initial amount: NaN
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
name: 4-hydroxy-2-oxoglutarate(2-)
boundary condition: false
is: CHEBI:17742
is: HMDB02070
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_985532c2_41cc_410b_bff5_86ddbe5dbea4
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: B2RBR4
is encoded by: hsa:6575
initial amount: NaN
name: SLC20A2
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_eab95e68_1059_4301_a7fb_162c3af3cbac
has only substance units: false
initial amount: NaN
is encoded by: hsa:6390
name: SDHB
type: Species
is: P21912
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_af2d908c_278f_4588_be3d_d66ca2f5ecbf
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q9Y6K8
is encoded by: hsa:26289
constant: false
has only substance units: false
name: AK5
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_0142426b_3b37_4a0f_b4ed_b6c1ead48125
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: DGKB
is encoded by: hsa:1607

metaM glx m
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: SBO:0000247
constant: false
is: CHEBI:36655
name: glyoxylate
initial concentration: 1.0
is: HMDB00119
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false

metaM naglc2p L c
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:18278
type: Species
notes: FORMULA: C1160H1898N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
initial concentration: 1.0
initial amount: NaN
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human liver homolog
has only substance units: false

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaR DURItn
is: SBO:0000185
kinetic law: MODEL1310110007#
name: deoxyuridine transport in nucleus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
product: MODEL1310110007#
reactant: MODEL1310110007#

metaR r0085
modifier: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.42
type: Reaction
reactant: MODEL1310110007#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
reversible: false
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3

metaR DMHPTCRNte
fast: false
name: 2,6 dimethylheptanoyl carnitine transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:unknown mechanism for transport -see PMID 9299016, identifies 2,6-dimethylheptanoyl carnitine in the urine! NJ
product: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_e987bdce_b501_4765_a5f4_0e58b116d895
initial amount: NaN
is encoded by: hsa:8170
boundary condition: true
is: SBO:0000252
name: SLC14A2
constant: false
initial concentration: NaN
is: Q15849
has only substance units: false
type: Species

metaR MECOALm
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
type: Reaction
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.4
reactant: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
fast: false
is described by: ECO:0000212
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.5
product: MODEL1310110007#

metaR RE0830C
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
name: RE0830
fast: false
kinetic law: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000000
reactant: MODEL1310110007#
is: SBO:0000176

metaR r1454
fast: false
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
reversible: false
is: SBO:0000185
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
type: Reaction

metaR DM ethamp r
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_c4b4ab75_988a_4608_a677_6304bba30676
name: RDH10
initial amount: NaN
is encoded by: hsa:157506
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is: Q8IZV5
has only substance units: false

metaR NADPtru
product: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
fast: false
kinetic law: MODEL1310110007#
name: NADP transporter, endoplasmic reticulum
reversible: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_bf7d20a2_e8f3_4876_9a9c_47541903d95c
is: SBO:0000252
constant: false
is: Q3I5F7
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: ACOT6
boundary condition: true
is encoded by: hsa:641372

metaM ru5p D r
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: CHEBI:58121
initial concentration: 1.0
name: D-ribulose 5-phosphate(2-)
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00618
type: Species

metaM prist x
name: pristanic acid
is: HMDB00795
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
is: CHEBI:51340
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaR FACOAL191
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:11591435 NOTES:current models suggest COAL activity occurs on outer peroxisomal membrane NJ
name: fatty-acid--CoA ligase
is described by: ECO:0000269
product: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
reversible: false
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR r0242
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.1
reactant: MODEL1310110007#
fast: false
modifier: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

metaM HC01401 m
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: (S)-3-Hydroxydodecanoyl-CoA
constant: false
has only substance units: false
type: Species
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
is: CHEBI:27668

metaR CO2ter
reversible: true
product: MODEL1310110007#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110007#
name: CO2 endoplasmic reticular transport via diffusion
reactant: MODEL1310110007#

metaR FORtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: FOR transporter, endoplasmic reticulum
reversible: true
is: SBO:0000185
reactant: MODEL1310110007#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110007#
product: MODEL1310110007#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_87a82065_b70e_496a_ad52_12643b59ecd5
has only substance units: false
is encoded by: hsa:10846
initial concentration: NaN
is: Q9Y233
name: PDE10A
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_93941d4e_18ef_4319_92db_8127f3032889
constant: false
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
name: HYALP1
is encoded by: hsa:26062
initial amount: NaN
is: SBO:0000252

metaM pro L e
has only substance units: false
is: CHEBI:17203
name: L-proline
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: HMDB00162
is: SBO:0000247
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145

http://identifiers.org/biomodels.db/MODEL1310110007#_05fc4020_2464_4e19_bf72_56bcaad0dcfa
initial concentration: NaN
initial amount: NaN
constant: false
name: _AI915649_1_c
is encoded by: hsa:AI915649
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true

metaR H2O2t
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
product: MODEL1310110007#
type: Reaction
reversible: true
name: hydrogen peroxide transport via diffusion

metaR RE1531M
reactant: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: RE1531

metaR M1316Mg
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.114
is: SBO:0000176
modifier: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
product: MODEL1310110007#
type: Reaction

metaR SERDGLYexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110007#
type: Reaction
modifier: MODEL1310110007#
reversible: true
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000304
name: D-Serine/Glycine reversible exchange
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110007#_c4283dd2_ffbe_4d15_ba85_0f50f48f8910
type: Species
initial concentration: NaN
constant: false
has only substance units: false
name: MTHFS
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10588
is: P49914
boundary condition: true

metaR FALDH
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.1
product: MODEL1310110007#
reactant: MODEL1310110007#
reversible: true
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
name: formaldehyde dehydrogenase
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD

metaR r1459
kinetic law: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110007#
name: Transport reaction
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110007#
is: SBO:0000185

metaR RE1447N
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
is described by: ECO:0000000
product: MODEL1310110007#
reactant: MODEL1310110007#
reversible: true
is: SBO:0000176
name: RE1447
kinetic law: MODEL1310110007#

metaR FAOXC2251836m
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110007#
kinetic law: MODEL1310110007#
name: Beta oxidation of fatty acid
type: Reaction
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110007#_3415119c_cb66_4a48_b654_e73f9cdffbff
is: P05091
constant: false
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:217
initial concentration: NaN
name: ALDH2
boundary condition: true
initial amount: NaN

metaM m6mpdol L r
type: Species
has only substance units: false
notes: FORMULA: C1660H2728N20O520P20 CHARGE: -20
constant: false
is: CHEBI:37635
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog

metaR r0084
modifier: MODEL1310110007#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.42
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
product: MODEL1310110007#
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#

metaM cmp m
name: CMP(2-)
has only substance units: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:60377
boundary condition: false
is: HMDB00095

metaM co2 m
has only substance units: false
name: CO2
is: HMDB01967
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: CHEBI:16526
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: SBO:0000247
is: C00011
boundary condition: false

metaR ICDHyrm
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
fast: false
modifier: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110007#
name: Isocitrate dehydrogenase (NADP+)
kinetic law: MODEL1310110007#

metaM g1m8mpdol L r
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: C05870
type: Species
constant: false
notes: FORMULA: C1840H3028N20O670P20 CHARGE: -20

metaR EX 3aib D LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-3-Amino-isobutanoate exchange
type: Reaction

metaM leuktrB4 e
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
constant: false
name: leukotriene B4(1-)
has only substance units: false
is: CHEBI:57461
is: HMDB01085
type: Species
boundary condition: false
initial concentration: 1.0

metaM ade e
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:16708
name: adenine
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
has only substance units: false
is: HMDB00034

metaM Lpipecol x
is: CHEBI:30913
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
is: HMDB00716
initial concentration: 1.0
boundary condition: false
name: L-pipecolic acid
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_b51f4937_00f6_42c8_9b41_9ef46429db92
initial amount: NaN
has only substance units: false
is: P04035
boundary condition: true
is: SBO:0000252
constant: false
type: Species
name: HMGCR
initial concentration: NaN
is encoded by: hsa:3156

metaM apoC Lys btn m
notes: FORMULA: C16H27N4O3SX CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: HMDB03134
constant: false
is: http://identifiers.org/pubchem.compound/7886
is: C05552
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
type: Species

metaM nadph m
name: Nicotinamide adenine dinucleotide phosphate - reduced
boundary condition: false
constant: false
is: HMDB00221
has only substance units: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial concentration: 1.0
is: CHEBI:57783
is: SBO:0000247
type: Species
initial amount: NaN
is: C00005

metaR MANtly
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110007#
reversible: false
product: MODEL1310110007#
type: Reaction
is: SBO:0000185
fast: false
name: mannose efflux from lysosome

metaM m5masnB2 g
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58401
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
is: HMDB06814
boundary condition: false
notes: FORMULA: C52H87N2O40X CHARGE: 0

metaR PCm
is version of: http://identifiers.org/ec-code/6.4.1.1
modifier: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is described by: ECO:0000269
reactant: MODEL1310110007#
is: SBO:0000176
type: Reaction
reversible: false
name: pyruvate carboxylase
fast: false
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance

metaR RE1447M
product: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
kinetic law: MODEL1310110007#
type: Reaction
name: RE1447
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.3.1.41
fast: false
is described by: ECO:0000000

metaM tre e
has only substance units: false
name: Trehalose
initial amount: NaN
is: C01083
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16551
constant: false
boundary condition: false
is: HMDB00975
type: Species
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083

metaM ksi deg7 l
initial amount: NaN
is: CHEBI:16953
constant: false
name: keratan sulfate I, degradation product 7
is: SBO:0000247
type: Species
notes: FORMULA: C210H337N15O181S10 CHARGE: -10
is: HMDB00812
boundary condition: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_75bfd0ff_712c_4881_b222_bd35d350a346
name: _AI620219_1_c
boundary condition: true
is encoded by: hsa:AI620219
has only substance units: false
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR r1010
reversible: true
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
name: Postulated transport reaction

metaR RE1518M
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
fast: false
modifier: MODEL1310110007#
reversible: true
product: MODEL1310110007#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.13
name: RE1518

metaM itp n
boundary condition: false
is: HMDB00189
is: CHEBI:57614
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: ITP(3-)
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081

metaM mi1p D c
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
is: CHEBI:58433
initial concentration: 1.0
constant: false
name: 1D-myo-inositol 1-phosphate(2-)
has only substance units: false
is: HMDB02985

metaM cmp n
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:60377
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
name: CMP(2-)
initial amount: NaN
has only substance units: false
is: HMDB00095

metaR r0083
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
product: MODEL1310110007#
is: SBO:0000176
modifier: MODEL1310110007#
reversible: true
kinetic law: MODEL1310110007#
type: Reaction
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is described by: ECO:0000000
fast: false
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.42

metaR r2139
is described by: ECO:0000000
product: MODEL1310110007#
modifier: MODEL1310110007#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction

metaR TMDPP
kinetic law: MODEL1310110007#
fast: false
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.4
modifier: MODEL1310110007#
product: MODEL1310110007#
is: SBO:0000176
type: Reaction
name: thymidine phosphorylase
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (1890.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.4 Confidence Level: 4 AUTHORS: PMID:7028324,PMID:718961,PMID:9693094 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110007#_6f1d9c0e_5240_4b6a_83f0_8461b46b08eb
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q5DSZ6
name: UGT1A8
is encoded by: hsa:54576
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_7c1568fc_2b7d_4705_97ab_fa10048b85f5
is: Q9BWD1
is encoded by: hsa:39
initial amount: NaN
constant: false
name: ACAT2
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_83e327a6_f25d_4b19_a457_f05a2dea4fe3
is: SBO:0000252
name: SLC17A2
initial concentration: NaN
initial amount: NaN
type: Species
is: O00624
has only substance units: false
is encoded by: hsa:10246
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110007#_9a13d5ca_0e19_4664_807b_c0e3696c1857
boundary condition: true
is encoded by: hsa:6718
has only substance units: false
is: P51857
initial concentration: NaN
constant: false
name: AKR1D1
initial amount: NaN
type: Species
is: SBO:0000252

metaR FAOXC8C6m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)m
type: Reaction

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaR RE1901R
reactant: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799,PMID:11279029 NOTES:
type: Reaction
reversible: true
is: SBO:0000176
name: RE1901
kinetic law: MODEL1310110007#
fast: false
product: MODEL1310110007#

metaR r1011
type: Reaction
is: SBO:0000185
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
reversible: false
product: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
is described by: ECO:0000000
name: Transport reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_3956a53f_fa84_464a_935b_2280ce966532
type: Species
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: Q6IBA0
is: SBO:0000252
initial amount: NaN
name: NDUFS5
is encoded by: hsa:4725

metaR r1384
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
fast: false
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
is: SBO:0000176
reversible: true
name: Guanosine aminohydrolase EC:3.5.4.15
is described by: ECO:0000000

metaR UGLT
modifier: MODEL1310110007#
name: UDPglucose--hexose-1-phosphate uridylyltransferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.12
fast: false
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
reactant: MODEL1310110007#
is described by: ECO:0000000

metaR ETF
reactant: MODEL1310110007#
is: SBO:0000176
name: electron transfer flavoprotein
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
fast: false
type: Reaction

metaR GLXtm
reversible: true
product: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
is: SBO:0000185
type: Reaction
name: glyoxylate transport, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110007#

metaR THRGLNexR
modifier: MODEL1310110007#
name: L-threonine/glycine reversible exchange
reactant: MODEL1310110007#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110007#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110007#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_59761dcd_f73c_4d29_a12c_d5e4dc6749c4
constant: false
initial concentration: NaN
has only substance units: false
name: _BC005314_1_x
initial amount: NaN
boundary condition: true
is encoded by: hsa:BC005314
type: Species
is: SBO:0000252

metaR MGSA
reactant: MODEL1310110007#
name: methylglyoxal synthase
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:Previously EC 4.2.99.11 this rxn represents the enzymatic conversion or non-enzymatic fragmentation of dhap to mthgxl - NCD
fast: false
type: Reaction
product: MODEL1310110007#

metaR RE2651R
name: RE2651
reversible: true
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
fast: false
is: SBO:0000176
kinetic law: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110007#

metaM ade c
is: C00147
is: HMDB00034
initial concentration: 1.0
type: Species
is: CHEBI:16708
initial amount: NaN
name: Adenine
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false

metaR TYRTA
is: SBO:0000176
product: MODEL1310110007#
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.6.1.1
type: Reaction
fast: false
modifier: MODEL1310110007#
is described by: ECO:0000269
reversible: true
name: tyrosine transaminase

http://identifiers.org/biomodels.db/MODEL1310110007#_62d6f043_f769_463c_8613_c0d4365665ca
name: ASPA
is: Q6FH48
initial amount: NaN
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:443
is: SBO:0000252

metaR XYLTt
reversible: true
kinetic law: MODEL1310110007#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
reactant: MODEL1310110007#
product: MODEL1310110007#
type: Reaction
name: Xylitol transport via passive diffusion
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110007#_7aa9b97b_f346_4a33_9ae3_1e780d3e64b1
initial concentration: NaN
is: O43677
boundary condition: true
is: SBO:0000252
name: NDUFC1
initial amount: NaN
has only substance units: false
is encoded by: hsa:4717
type: Species
constant: false

metaR MG2er
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
is described by: ECO:0000000
is: SBO:0000176
reversible: false
reactant: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
fast: false

metaR r1012
name: Postulated transport reaction
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110007#
is: SBO:0000185

metaR RE0827E
type: Reaction
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: false
fast: false
product: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
name: RE0827
is version of: http://identifiers.org/ec-code/1.4.3.22
reactant: MODEL1310110007#

metaR GLNyLATthc
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glutamine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaR PIPLC
product: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.11
fast: false
reactant: MODEL1310110007#
is: SBO:0000176
modifier: MODEL1310110007#
type: Reaction
name: phosphatidylinositol phospholipase C

metaM HC01522 c
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:28508
name: Gentisate aldehyde
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_1014a907_6ec9_44b4_a1df_4d373abf51ce
has only substance units: false
boundary condition: true
name: NAE1
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: A8MU28
type: Species
is encoded by: hsa:8883

http://identifiers.org/biomodels.db/MODEL1310110007#_d3bd6178_475c_47f1_9024_b2455fc98d17
boundary condition: true
has only substance units: false
is encoded by: hsa:5136
is: Q9Y633
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: PDE1A
initial amount: NaN

metaR r2338
product: MODEL1310110007#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
is: SBO:0000185

metaR RE1807M
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
modifier: MODEL1310110007#
is: SBO:0000176
reactant: MODEL1310110007#
reversible: true
name: RE1807
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_5fd45383_fd62_4e72_a9c9_0b890f827999
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: PHPT1
is: SBO:0000252
type: Species
is encoded by: hsa:29085
has only substance units: false
is: Q9P019

metaM 6dhf e
has only substance units: false
constant: false
is: HMDB06563
name: hexaglutamyl folate (DHF)
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
initial amount: NaN
boundary condition: false

metaR P45027A14m
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
reactant: MODEL1310110007#
name: 5-beta-cytochrome P450, family 27, subfamily A, polypeptide 1
fast: false
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110007#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110007#

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaM andrstrn c
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16032
type: Species
is: SBO:0000247
name: androsterone
boundary condition: false
is: HMDB00031
has only substance units: false
constant: false

metaR PGLer
is described by: ECO:0000269
name: 6-phosphogluconolactonase, endoplasmic reticulum
product: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
kinetic law: MODEL1310110007#
fast: false
modifier: MODEL1310110007#
is version of: http://identifiers.org/ec-code/1.1.1.47
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110007#_8aa02148_1947_42ba_b853_bf6b6ab3d762
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:AI926493
name: _AI926493_1_c

metaR TMDPK
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
is described by: ECO:0000269
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.6.2

metaM CE1939 e
name: spermidine monoaldehyde 1
is: CHEBI:36781
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-1-2-5-9-6-3-7-10/h7,9H,1-6,8H2/p+2 EHMN_ABBREVIATION: CE1939
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_e8b205a0_659e_453b_a012_abe89e5cb7c8
is: P14672
initial amount: NaN
is: SBO:0000252
name: SLC2A4
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:6517
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_metaR_EX_acn13acngalgbside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sialyl (1,3) sialyl (2,6) galactosylgloboside (homo sapiens) exchange
type: Reaction

metaM CE2417 m
is: SBO:0000247
is: CHEBI:28387
boundary condition: false
initial amount: NaN
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
initial concentration: 1.0
constant: false
is: HMDB11123
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
type: Species
has only substance units: false

metaM btamp c
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB04220
is: SBO:0000247
is: CHEBI:3110
name: Biotinyl-5'-AMP
type: Species
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921

metaR r2333
kinetic law: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110007#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is: SBO:0000185
reactant: MODEL1310110007#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_e978f405_cf09_451a_ad5a_76a69a58840f
has only substance units: false
is: SBO:0000252
type: Species
is: O76062
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:7108
boundary condition: true
name: TM7SF2
constant: false

metaR EX pectingchol LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectin-glycocholate complex
type: Reaction

metaM 2dodtricoa m
constant: false
name: 2,6,9-dodecatrienoylcoa
is: HMDB03952
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
is: C05280

http://identifiers.org/biomodels.db/MODEL1310110007#_244b3123_d2fe_4744_849a_b21753198dc7
is: Q9Y619
is: SBO:0000252
is encoded by: hsa:10166
name: SLC25A15
initial concentration: NaN
type: Species
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false

metaM glx x
is: HMDB00119
initial amount: NaN
type: Species
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:36655
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
initial concentration: 1.0
name: glyoxylate
is: SBO:0000247

metaM ser D e
constant: false
name: D-serine
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:16523
has only substance units: false
is: SBO:0000247
is: HMDB03406
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110007#_c0d4be36_e7f6_424d_98a8_78d6fe90a19c
initial amount: NaN
is encoded by: hsa:6713
name: SQLE
constant: false
is: Q5HYI4
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_475fc8f6_3041_44d2_9390_0ec4560ed6cd
name: _AI090874_1_c
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:AI090874
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110007#_69bbd079_5539_4e4e_8e90_2f1869380165
constant: false
is encoded by: hsa:1119
boundary condition: true
has only substance units: false
initial amount: NaN
name: CHKA
type: Species
initial concentration: NaN
is: SBO:0000252

metaR TDCHOLAte
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
product: MODEL1310110007#
fast: false
is: SBO:0000185
name: bile acid intracellular transport
is described by: ECO:0000000

metaR EX nac LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinate exchange
type: Reaction

metaR RE0830N
is version of: http://identifiers.org/ec-code/4.2.1.96
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
fast: false
name: RE0830
reactant: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reversible: true

metaR ACCOAtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110007#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110007#
name: acetyl-CoA transport, nuclear
reactant: MODEL1310110007#

metaM glyphe c
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/97415
name: Glycylphenylalanine
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C11H14N2O3 CHARGE: 0
constant: false

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_b365a7a3_4f6a_41ce_898e_ea4f0ba8430d
name: B3GALT5
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10317
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_defb5afd_9536_475d_ad65_2a5d2d30ec25
boundary condition: true
name: BTD
is: P43251
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:686
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_81a3378b_b070_46d3_9892_2e09d812bf2b
is: SBO:0000252
constant: false
is encoded by: hsa:11182
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
name: SLC2A6
is: Q9UGQ3
initial amount: NaN

metaM 4nphsf e
boundary condition: false
name: 4-Nitrophenyl sulfate
constant: false
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
is: HMDB06492
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:35422
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110007#_e57d670e_2712_42ef_ab8b_b5b583e827d7
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3425
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
name: IDUA
type: Species
is: P35475

metaR GLXtp
product: MODEL1310110007#
reactant: MODEL1310110007#
type: Reaction
name: glyoxylate transport, peroxisomal
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110007#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD

metaR MTHFDm
fast: false
is described by: ECO:0000269
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
is version of: http://identifiers.org/ec-code/3.5.4.9
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.3
reversible: true
is: SBO:0000176
modifier: MODEL1310110007#
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
product: MODEL1310110007#

metaM ala L m
is: CHEBI:16977
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: SBO:0000247
name: L-alanine
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00161

http://identifiers.org/biomodels.db/MODEL1310110007#_9c8f409f_f4f9_4109_9b97_b2332a9f6ad0
initial amount: NaN
is: B4DDW0
constant: false
is encoded by: hsa:51109
name: RDH11
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaR GLRASE
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 1.1.1.20 Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110007#
name: glucuronolactone reductase
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000176
is described by: ECO:0000000

metaR r2332
reactant: MODEL1310110007#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110007#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR BTNPL
is version of: http://identifiers.org/ec-code/6.3.4.10
product: MODEL1310110007#
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
is: SBO:0000176
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
is described by: ECO:0000000
type: Reaction
name: holocarboxylase synthestase (biotin protein ligase)

metaR RE2974C
is version of: http://identifiers.org/ec-code/2.7.1.149
is described by: ECO:0000000
fast: false
reversible: true
name: RE2974
product: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.68
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
reactant: MODEL1310110007#
modifier: MODEL1310110007#
is: SBO:0000176
kinetic law: MODEL1310110007#

metaM co2 r
is: HMDB01967
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: C00011
is: CHEBI:16526
name: CO2

metaM nicrnt c
name: Nicotinate D-ribonucleotide
is: C01185
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:57502
constant: false
boundary condition: false
is: HMDB01132
initial concentration: 1.0

metaM mi1345p c
is: SBO:0000247
is: HMDB01059
constant: false
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
initial amount: NaN
is: CHEBI:57895
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false

metaM sql r
is: CHEBI:15440
type: Species
is: SBO:0000247
name: squalene
is: HMDB00256
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
initial amount: NaN
has only substance units: false

metaM adprbp e
constant: false
notes: FORMULA: C15H20N5O17P3 CHARGE: -4 INCHI: InChI=1S/C15H24N5O17P3/c16-12-7-13(18-3-17-12)20(4-19-7)14-11(35-38(25,26)27)9(23)6(33-14)2-32-39(28,29)37-40(30,31)36-15-10(24)8(22)5(1-21)34-15/h3-6,8-11,14-15,21-24H,1-2H2,(H,28,29)(H,30,31)(H2,16,17,18)(H2,25,26,27)/p-4/t5-,6-,8-,9-,10-,11-,14-,15?/m1/s1 EHMN_ABBREVIATION: C03246
initial concentration: 1.0
is: SBO:0000247
is: HMDB06336
has only substance units: false
name: ADP-D-ribose 2'-phosphate(4-)
boundary condition: false
is: CHEBI:58673
type: Species
initial amount: NaN

metaM didp c
is: SBO:0000247
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
is: CHEBI:28823
constant: false
is: HMDB03536
initial concentration: 1.0
boundary condition: false
name: dIDP
initial amount: NaN
has only substance units: false
type: Species

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

metaR r0941
product: MODEL1310110007#
name: Free diffusion
reactant: MODEL1310110007#
is: SBO:0000185
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_96af5204_ea01_4a35_b996_69a800608ee5
is: G3V0F6
name: DGKZ
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8525
initial concentration: NaN
has only substance units: false

metaM pro L c
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial concentration: 1.0
is: CHEBI:17203
initial amount: NaN
type: Species
constant: false
is: HMDB00162
is: SBO:0000247
has only substance units: false
name: L-proline
boundary condition: false

metaR r0354
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
reversible: false
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#

metaR r0249
reversible: true
is version of: http://identifiers.org/ec-code/2.7.7.12
reactant: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
is described by: ECO:0000000
product: MODEL1310110007#
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6

http://identifiers.org/biomodels.db/MODEL1310110007#_93e97937_9729_4c12_ae08_841ed1e326b8
initial concentration: NaN
name: MSMO1
is: A8MYF6
is: SBO:0000252
is encoded by: hsa:6307
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true

metaR r2335
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
kinetic law: MODEL1310110007#
is: SBO:0000185
reactant: MODEL1310110007#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110007#

metaM dcamp c
is: C03794
is: CHEBI:57567
name: N6-(1,2-Dicarboxyethyl)-AMP
is: HMDB00536
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
constant: false

metaR r1380
fast: false
is described by: ECO:0000000
reactant: MODEL1310110007#
type: Reaction
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110007#

metaR TRIODTHYt2
reversible: true
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is described by: ECO:0000269
fast: false
name: T3 transport via facilitated diffusion
modifier: MODEL1310110007#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110007#
product: MODEL1310110007#
kinetic law: MODEL1310110007#

metaR HMGCOARc
product: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.34
modifier: MODEL1310110007#
type: Reaction
is described by: ECO:0000134
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
reactant: MODEL1310110007#
fast: false

metaR DURAD
reactant: MODEL1310110007#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.1.2
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
name: dihydrouracil dehydrogenase (NADP)
type: Reaction
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
product: MODEL1310110007#
fast: false

metaM retn r
constant: false
name: all-trans-retinoate
is: HMDB01852
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial concentration: 1.0
initial amount: NaN
is: CHEBI:35291
type: Species

metaM amp m
boundary condition: false
initial concentration: 1.0
is: HMDB00045
has only substance units: false
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: CHEBI:456215
is: SBO:0000247
name: AMP(2-)
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_8ab676d1_84bd_4b20_a176_a2fec26142ae
type: Species
is: SBO:0000252
name: HAO2
constant: false
has only substance units: false
is encoded by: hsa:51179
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q9NYQ3

http://identifiers.org/biomodels.db/MODEL1310110007#_41ceafb3_cc4d_403c_af37_f37efd6de792
name: SLC5A12
has only substance units: false
is: SBO:0000252
type: Species
is: Q1EHB4
initial concentration: NaN
is encoded by: hsa:159963
constant: false
initial amount: NaN
boundary condition: true

metaM pi x
name: hydrogenphosphate
is: SBO:0000247
is: HMDB00973
initial concentration: 1.0
constant: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:43474
has only substance units: false

metaR SRTNtu
reversible: true
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
name: Serotonin uniport
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
product: MODEL1310110007#
fast: false

metaR r0940
reactant: MODEL1310110007#
product: MODEL1310110007#
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Free diffusion
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM ser D c
is: SBO:0000247
is: HMDB03406
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:16523
initial amount: NaN
name: D-serine
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1

metaR SARDHm
is version of: http://identifiers.org/ec-code/1.5.99.1
is: SBO:0000176
fast: false
reactant: MODEL1310110007#
name: Sarcosine dehydrogenase (m)
reversible: false
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
type: Reaction
product: MODEL1310110007#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable

metaR THFtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reactant: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
fast: false
product: MODEL1310110007#
kinetic law: MODEL1310110007#

metaR r0355
modifier: MODEL1310110007#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is version of: http://identifiers.org/ec-code/4.2.1.3
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
reversible: false
fast: false

metaM leuktrB4 c
constant: false
initial amount: NaN
is: CHEBI:57461
is: SBO:0000247
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial concentration: 1.0
name: leukotriene B4(1-)
has only substance units: false
is: HMDB01085
boundary condition: false

metaR S6TASE20ly
type: Reaction
fast: false
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110007#
reactant: MODEL1310110007#

metaR 7DHCHSTEROLtr
is: SBO:0000185
reversible: true
reactant: MODEL1310110007#
name: cholesterol precursor intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
product: MODEL1310110007#
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110007#

http://identifiers.org/biomodels.db/MODEL1310110007#_d287f49b_7f97_4e48_8be5_a0cae28c5eb7
is encoded by: hsa:22934
is: P49247
constant: false
has only substance units: false
name: RPIA
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR r2334
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#

metaM 4nphsf c
is: SBO:0000247
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
has only substance units: false
is: HMDB06492
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: CHEBI:35422
name: 4-Nitrophenyl sulfate
boundary condition: false

metaR r1381
type: Reaction
product: MODEL1310110007#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
reversible: true
kinetic law: MODEL1310110007#
is described by: ECO:0000000
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
reactant: MODEL1310110007#

metaM dump n
constant: false
name: dUMP(2-)
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: HMDB01409
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:246422
has only substance units: false
initial concentration: 1.0

metaR XOLDIOLONEt
product: MODEL1310110007#
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110007#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110007#
name: lipid, flip-flop intracellular transport

metaM L2aadp6sa c
constant: false
is: HMDB01263
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17917
type: Species
name: L-allysine
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
boundary condition: false

metaR ADRNCOAtx
type: Reaction
reactant: MODEL1310110007#
name: fatty acid intracellular transport
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110007#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_625f093d_4dd8_4aab_9e54_6130906a4eef
has only substance units: false
is: SBO:0000252
name: AKR1A1
type: Species
is encoded by: hsa:10327
initial amount: NaN
is: P14550
constant: false
initial concentration: NaN
boundary condition: true

metaR DGCHOLtx
reversible: true
name: bile acid intracellular transport
kinetic law: MODEL1310110007#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110007#
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
is: SBO:0000185

metaR r2131
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110007#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110007#
fast: false
reactant: MODEL1310110007#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_53c5ebd2_30dd_41c8_b7db_91410e9a5aed
is encoded by: hsa:30
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial concentration: NaN
name: ACAA1
is: Q96CA6
boundary condition: true
initial amount: NaN

metaR SQLSr
is version of: http://identifiers.org/ec-code/2.5.1.21
name: Squalene synthase
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
modifier: MODEL1310110007#
is described by: ECO:0000134
product: MODEL1310110007#
reactant: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#

metaR 7DHFtm
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:unknown mechanism. IT
product: MODEL1310110007#
is: SBO:0000185
name: 7-glutamyl-DHF transport,m mitochondrial
kinetic law: MODEL1310110007#

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaM crvnc e
type: Species
is: HMDB02183
initial amount: NaN
is: CHEBI:36005
boundary condition: false
notes: FORMULA: C22H31O2 CHARGE: -1
name: cervonic acid, C22:6 n-3
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM arachcoa m
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:15527
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
name: arachidyl coenzyme A
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB04258
is: SBO:0000247

metaR GLUTCOADHm
name: glutaryl-CoA dehydrogenase (mitochondria)
type: Reaction
is: SBO:0000176
reactant: MODEL1310110007#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.7
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
modifier: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000304
reversible: false

metaR r1018
fast: false
type: Reaction
reversible: true
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
kinetic law: MODEL1310110007#
name: Transport reaction

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaR FAOXC160
product: MODEL1310110007#
name: Beta oxidation of long chain fatty acid
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is: SBO:0000176
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
fast: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110007#_8cf3b43e_4cfa_4d7c_8cb9_57cfb1d80c74
constant: false
is encoded by: hsa:10935
is: SBO:0000252
initial amount: NaN
is: E9PH29
has only substance units: false
initial concentration: NaN
boundary condition: true
name: PRDX3
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_b33739a8_68ff_4752_9e37_46c09437272d
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: true
name: SLC23A2
is encoded by: hsa:9962
is: SBO:0000252

metaM phe L e
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: HMDB00159
name: L-phenylalanine
is: CHEBI:17295
boundary condition: false
initial amount: NaN

metaM cmp e
is: SBO:0000247
type: Species
is: CHEBI:60377
is: HMDB00095
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: CMP(2-)

metaM co2 e
is: SBO:0000247
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
type: Species
is: HMDB01967
name: CO2
constant: false
initial amount: NaN
is: C00011
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:16526

metaM hs deg1 l
has only substance units: false
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
name: heparan sulfate, degradation product 1
initial concentration: 1.0
is: HMDB01352
is: CHEBI:17180

metaR GLCURtly
is described by: ECO:0000269
product: MODEL1310110007#
modifier: MODEL1310110007#
fast: false
kinetic law: MODEL1310110007#
reversible: true
is: SBO:0000185
name: glucuronate transport into lysososme
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110007#_ccbafd8a_2a69_4c9c_9a53_0dce25991403
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AV717590
has only substance units: false
is: SBO:0000252
constant: false
type: Species
name: _AV717590_1_c
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_5594e950_5bb8_466a_a046_e29256bda2d0
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is: Q6FGV9
boundary condition: true
is encoded by: hsa:10654
has only substance units: false
name: PMVK

metaM m2mpdol L c
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:28049
initial concentration: 1.0
notes: FORMULA: C1420H2328N20O320P20 CHARGE: -20
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
constant: false

metaR DOLPMT4 Ler
reactant: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
fast: false
type: Reaction
is: SBO:0000185
reversible: false
product: MODEL1310110007#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)

http://identifiers.org/biomodels.db/MODEL1310110007#_4010b555_afa1_4157_9d17_026321c1fc94
name: BCAT1
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P54687
type: Species
is encoded by: hsa:586

metaM 3mob m
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
initial concentration: 1.0
is: HMDB00019
boundary condition: false
is: SBO:0000247
type: Species
constant: false
has only substance units: false
name: 3-methyl-2-oxobutanoate
initial amount: NaN
is: CHEBI:11851

metaM itp e
name: ITP(3-)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: CHEBI:57614
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00189

metaR G12MT2 L
reactant: MODEL1310110007#
reversible: false
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:

metaM cdpdag hs c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: CDP-diacylglycerol(2-)
type: Species
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
is: CHEBI:58332
initial amount: NaN
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110007#_d37c073c_77d1_4dce_82e0_1e258f688800
is encoded by: hsa:6472
is: SBO:0000252
constant: false
initial concentration: NaN
name: SHMT2
is: B4DJQ3
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110007#_e71081b7_d501_4fcf_a7fe_d749e0812c3d
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: O95169
name: NDUFB8
type: Species
is encoded by: hsa:4714

metaR PGCD
fast: false
kinetic law: MODEL1310110007#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26227.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
name: phosphoglycerate dehydrogenase
modifier: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
product: MODEL1310110007#
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.95

metaR DNDPt15m
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
is described by: ECO:0000269
name: dUDP transport via dGDP antiport
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reactant: MODEL1310110007#
product: MODEL1310110007#
fast: false
is: SBO:0000185

metaR RE0453C
product: MODEL1310110007#
fast: false
name: RE0453
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is: SBO:0000176
reactant: MODEL1310110007#
reversible: true

metaR r2130
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110007#
is: SBO:0000185
product: MODEL1310110007#
reactant: MODEL1310110007#
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR NRVNCt
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
product: MODEL1310110007#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true

metaR GLYt7 311 r
kinetic law: MODEL1310110007#
is: SBO:0000185
reactant: MODEL1310110007#
name: glycine reversible transport via sodium and chloride symport (3:1:1)
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110007#
fast: false
is described by: ECO:0000006
modifier: MODEL1310110007#
reversible: true
type: Reaction

metaM utp n
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: HMDB00285
is: CHEBI:46398
is: SBO:0000247
constant: false
name: UTP(4-)
type: Species
has only substance units: false

metaR r0838
name: Free diffusion
is: SBO:0000185
product: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.1.2.4
type: Reaction
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
fast: false
reversible: true
is described by: ECO:0000000

metaR PI45P3K
product: MODEL1310110007#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
kinetic law: MODEL1310110007#
fast: false
type: Reaction
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/2.7.1.153
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
modifier: MODEL1310110007#

metaR SGALSIDEtl
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
kinetic law: MODEL1310110007#
product: MODEL1310110007#
name: sgalside hs intracellular transport
fast: false
is: SBO:0000185
reactant: MODEL1310110007#
reversible: true
type: Reaction

metaM ocdca c
is: SBO:0000247
is: CHEBI:25629
initial amount: NaN
has only substance units: false
is: HMDB00827
boundary condition: false
type: Species
name: stearate
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
initial concentration: 1.0
constant: false

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

metaR GALK
product: MODEL1310110007#
modifier: MODEL1310110007#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.6
fast: false
reactant: MODEL1310110007#
name: galactokinase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.157
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH

metaM retinal cis 13 r
is: CHEBI:45487
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
name: 13-cis-retinal
is: SBO:0000247
is: HMDB06220
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
has only substance units: false
initial amount: NaN

metaM apoC Lys btn c
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: HMDB00182
boundary condition: false
type: Species
is: CHEBI:32551
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C16H27N4O3SX CHARGE: 0

metaR GALASE11ly
name: beta-galactosidase, lysosomal
reversible: false
kinetic law: MODEL1310110007#
product: MODEL1310110007#
modifier: MODEL1310110007#
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
reactant: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110007#_73f77ce6_011e_48ae_8582_4641500495ce
boundary condition: true
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
name: GSR
is encoded by: hsa:2936
is: P00390
has only substance units: false

metaR RNDR4
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
kinetic law: MODEL1310110007#
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
name: ribonucleoside-diphosphate reductase (UDP)
reactant: MODEL1310110007#
modifier: MODEL1310110007#
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110007#

metaR ACOAD10m
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
reactant: MODEL1310110007#
reversible: false
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
is: SBO:0000176
product: MODEL1310110007#
is described by: ECO:0000269
kinetic law: MODEL1310110007#
type: Reaction

metaM xtsn c
is: HMDB00299
is: SBO:0000247
is: CHEBI:18107
initial concentration: 1.0
name: xanthosine
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaR DOPAtu
name: Dopamine uniport
product: MODEL1310110007#
is described by: ECO:0000269
modifier: MODEL1310110007#
kinetic law: MODEL1310110007#
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110007#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110007#_573e7472_45ae_44b1_8741_d0ed7c536654
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
has only substance units: false
name: B3GALT5
initial amount: NaN
boundary condition: true
is encoded by: hsa:10317

metaR ALADGLNexR
name: L-alanine/glutamine reversible exchange
reversible: true
kinetic law: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110007#
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110007#

metaR LEUKTRD4t
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110007#
name: leukotriene D4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#

metaR PTCRTD
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
is described by: ECO:0000134
type: Reaction
reversible: true
reactant: MODEL1310110007#
product: MODEL1310110007#
name: diffusion of putriscine into the endothelial cells
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110007#_8a247a26_a766_490e_8cdf_888b6d272bef
type: Species
constant: false
is: P33897
has only substance units: false
name: ABCD1
initial amount: NaN
boundary condition: true
is encoded by: hsa:215
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_414b8a7f_6762_4cef_b112_871834bd4482
is encoded by: hsa:4953
is: SBO:0000252
initial concentration: NaN
is: P11926
name: ODC1
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false

metaM lald D c
is: SBO:0000247
type: Species
is: HMDB06458
initial concentration: 1.0
is: CHEBI:17167
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
boundary condition: false
has only substance units: false
constant: false
name: (R)-lactaldehyde
initial amount: NaN

metaR r2330
is: SBO:0000185
product: MODEL1310110007#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110007#
fast: false
type: Reaction
reactant: MODEL1310110007#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR EX dmhptcrn LPAREN e RPAREN
kinetic law: MODEL1310110007#
reactant: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2,6 dimethylheptanoyl carnitine exchange
type: Reaction

metaR r2133
is described by: ECO:0000000
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
reversible: true
is: SBO:0000185
fast: false
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110007#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110007#_f11a6076_135a_464c_bf5e_944b45ae81eb
initial amount: NaN
constant: false
boundary condition: true
name: ARSA
is encoded by: hsa:410
is: P15289
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false

metaR r0839
product: MODEL1310110007#
modifier: MODEL1310110007#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.70
type: Reaction
name: Postulated transport reaction
is: SBO:0000185
reactant: MODEL1310110007#
reversible: true
fast: false
kinetic law: MODEL1310110007#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:

metaR RE1709C
kinetic law: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
name: RE1709
fast: false
is: SBO:0000176
product: MODEL1310110007#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:

metaR MTHGXLt
type: Reaction
is: SBO:0000185
reactant: MODEL1310110007#
is described by: ECO:0000000
kinetic law: MODEL1310110007#
name: Methylglyoxal transport (cytosol to extracellular)
fast: false
product: MODEL1310110007#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
reversible: false

metaR SUCOAS1m
fast: false
name: Succinate--CoA ligase (GDP-forming)
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
reactant: MODEL1310110007#
type: Reaction
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110007#
is described by: ECO:0000000
product: MODEL1310110007#
modifier: MODEL1310110007#

metaM 5fthf m
is: HMDB01562
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
type: Species
is: CHEBI:57457
boundary condition: false
is: SBO:0000247
constant: false
name: 5-formyltetrahydrofolate(2-)

metaM cmp g
is: HMDB00095
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species
is: CHEBI:60377
constant: false
name: CMP(2-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110007#_b10db19b_fe08_44b6_ad38_6d6a8df434a6
is: P55084
constant: false
is encoded by: hsa:3032
name: HADHB
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110007#_d81af63f_a0ef_41ff_a1a9_d53a02bf0bfe
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: SULT1A2
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:6799
type: Species

metaM CE5787 e
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C15H31N6O4 CHARGE: 1 INCHI: InChI=1/C15H30N6O4/c1-4-8(2)11(16)13(23)20-9(3)12(22)21-10(14(24)25)6-5-7-19-15(17)18/h8-11H,4-7,16H2,1-3H3,(H,20,23)(H,21,22)(H,24,25)(H4,17,18,19)/p+1/t8-,9+,10-,11-/m1/s1 EHMN_ABBREVIATION: CE5787
initial amount: NaN
is: CHEBI:27485
has only substance units: false
type: Species
is: HMDB02710
name: kinetensin 1-3
is: SBO:0000247

metaM phe L c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
type: Species
constant: false
is: SBO:0000247
name: L-phenylalanine
is: HMDB00159
has only substance units: false
boundary condition: false
is: CHEBI:17295

metaM xu5p D c
initial amount: NaN
is: HMDB00868
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
name: D-xylulose 5-phosphate(2-)
is: CHEBI:57737
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_94b25462_f48c_44ad_b862_d90620d10cc5
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:6582
name: SLC22A2
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_9ba270ee_b0f0_4503_b079_52a9378167b9
is encoded by: hsa:8813
is: SBO:0000297
name: DPM3:DPM1:DPM2
initial amount: NaN
has part: O60762
initial concentration: NaN
is encoded by: hsa:54344
boundary condition: true
constant: false
is encoded by: hsa:8818
type: Species
has part: O94777
has only substance units: false
has part: Q86TM7

metaR FAOXC81C61m
kinetic law: MODEL1310110007#
product: MODEL1310110007#
reactant: MODEL1310110007#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

metaR GLCNACASE2ly
modifier: MODEL1310110007#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110007#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
name: alpha-N-acetylglucosaminidase, lysosomal
product: MODEL1310110007#
kinetic law: MODEL1310110007#
is version of: http://identifiers.org/ec-code/3.2.1.50

metaM pristanal c
has only substance units: false
type: Species
is: HMDB01958
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C19H38O CHARGE: 0 INCHI: InChI=1S/C19H38O/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20/h15-19H,6-14H2,1-5H3
name: pristanal
initial amount: NaN
constant: false
is: CHEBI:49189

metaM 5dpmev x
is: SBO:0000247
initial amount: NaN
is: HMDB01090
initial concentration: 1.0
type: Species
is: CHEBI:15899
boundary condition: false
constant: false
name: (R)-5-Diphosphomevalonate
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00685 EHMN_ABBREVIATION: C01143
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110007#_3e524703_390b_47fe_bd26_26a97edb9c11
initial concentration: NaN
has only substance units: false
name: SLC35A2
is encoded by: hsa:7355
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is: P78381
initial amount: NaN

metaM crvnc c
is: HMDB02183
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: cervonic acid, C22:6 n-3
constant: false
is: SBO:0000247
is: CHEBI:36005
type: Species
notes: FORMULA: C22H31O2 CHARGE: -1

metaM itp c
initial amount: NaN
constant: false
is: HMDB00189
name: ITP(3-)
has only substance units: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: CHEBI:57614
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110007#_2f360869_5f79_4631_a81a_79bac804af0b
is encoded by: hsa:84569
is: Q6UWQ5
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: LYZL1
initial amount: NaN

metaM nac c
boundary condition: false
initial concentration: 1.0
is: HMDB01488
is: CHEBI:0
notes: FORMULA: C6H4NO2 CHARGE: -1
constant: false
type: Species
is: C00253
initial amount: NaN
has only substance units: false
name: Nicotinate
is: SBO:0000247

metaR r2132
product: MODEL1310110007#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
modifier: MODEL1310110007#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110007#
kinetic law: MODEL1310110007#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110007#_fb31637f_2170_465b_9d72_13c5bad23539
is encoded by: hsa:56606
initial concentration: NaN
has only substance units: false
constant: false
name: SLC2A9
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR r2331
product: MODEL1310110007#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110007#
type: Reaction
reactant: MODEL1310110007#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false

metaM hs deg4 l
type: Species
name: heparan sulfate, degradation product 4
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:16126
is: SBO:0000247
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
boundary condition: false

metaR 7DHFtl
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110007#
product: MODEL1310110007#
reversible: false
kinetic law: MODEL1310110007#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:carrier-mediated transport - but which and how is unknown IT
name: 7-glutamyl-DHF transport, lysosomal
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110007#_523b9f9d_edf7_4db7_b61f_1cda827c240f
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: GLDC
is encoded by: hsa:2731
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: P23378